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Pneumocystis pneumonia

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In the era before the existence of HIV/AIDS in humans, clinical transplant immunology, and widespread immunomodulatory therapy for autoimmune diseases, the neonatal and infantile population was the principal immunity-limited population. For example, a 1955 review article stated, "Interstitial plasma
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study conducted in Chile of 96 persons who died of unrelated causes (suicide, traffic accidents, and so forth) found that 65 (68%) of them had pneumocystis in their lungs, which suggests that asymptomatic pneumocystis infection is extremely common. Up to 20% of adults may be asymptomatic carriers at
524:, which typically do not form aggregates of spores or cells). A lung biopsy would show thickened alveolar septa with fluffy eosinophilic exudate in the alveoli. Both the thickened septa and the fluffy exudate contribute to dysfunctional diffusion capacity that is characteristic of this pneumonia. 466: 756:
epidemic, PCP has been closely associated with AIDS. Because it only occurs in an immunocompromised host, it may be the first clue to a new AIDS diagnosis if the patient has no other reason to be immunocompromised (e.g. taking immunosuppressive drugs for
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cell pneumonia is a type of infantile pneumonia, occurring chiefly in Europe." It also stated, "The etiology is unknown, but the disease acts like an infection in its epidemiology. No present-day therapeutic measures seem to be of any definite value."
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is commonly believed to be a commensal organism (dependent upon its human host for survival). The possibility of person-to-person transmission has recently gained credence, with supporting evidence coming from many different genotyping studies of
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Prior to the development of more effective treatments, PCP was a common and rapid cause of death in persons living with AIDS. Much of the incidence of PCP has been reduced by instituting a standard practice of using oral
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Masur H, Michelis MA, Greene JB, Onorato I, Stouwe RA, Holzman RS, et al. (December 1981). "An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction".
693:, such as premature or severely malnourished children, the elderly, and especially persons living with HIV/AIDS (in whom it is most commonly observed). PCP can also develop in patients who are taking 409:
are also useful in the diagnosis. They are abnormal in about 90% of cases and are often positive before the chest X-ray becomes abnormal. Chest X-ray typically shows widespread pulmonary infiltrates.
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individuals, the manifestations of the infection are highly variable. The disease attacks the interstitial, fibrous tissue of the lungs, with marked thickening of the alveolar septa and
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pneumonia, it was at first asked whether "PJP" should replace "PCP". However, because the short name "PCP" was already well established among physicians that managed patients with
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to avoid inflammation, which causes an exacerbation of symptoms about 4 days after treatment begins if steroids are not used. By far, the most commonly used medication is
1814:"An outbreak of Pneumocystis jiroveci pneumonia with 1 predominant genotype among renal transplant recipients: interhuman transmission or a common environmental source?" 994:
Aliouat-Denis CM, Chabé M, Demanche C, Aliouat EM, Viscogliosi E, Guillot J, et al. (September 2008). "Pneumocystis species, co-evolution and pathogenic power".
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Ponce CA, Gallo M, Bustamante R, Vargas SL (February 2010). "Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population".
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Ponce CA, Gallo M, Bustamante R, Vargas SL (February 2010). "Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population".
761:). An unusual rise in the number of PCP cases in North America, noticed when physicians began requesting large quantities of the rarely used antibiotic 1225: 4099: 1181:
Kanne JP, Yandow DR, Meyer CA (June 2012). "Pneumocystis jiroveci pneumonia: high-resolution CT findings in patients with and without HIV infection".
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levels increase and gas exchange is compromised. Oxygen is less able to diffuse into the blood, leading to hypoxia, which along with high arterial
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counts less than 200/μL. In populations who do not have access to preventive treatment, PCP continues to be a major cause of death in AIDS.
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specimens are commonly found in the lungs of healthy people although it is usually not a cause for disease. However, they are a source of
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pneumonia, the overgrowth of the fungus is associated to a co-infection with trichomonads, unicellular flagellated parabasalid protist (
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HRCT of cysts of pneumocystis pneumonia. These are usually multiple and bilateral, but range in size, shape and distribution.
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de Boer MG, Bruijnesteijn van Coppenraet LE, Gaasbeek A, Berger SP, Gelinck LB, van Houwelingen HC, et al. (May 2007).
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The diagnosis can be definitively confirmed by histological identification of the causative organism in sputum or
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name per se and the other uses the common noun based on it. (This is the same reason, for example, why "group A
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The disease PCP is relatively rare in people with normal immune systems, but common among people with weakened
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any given time, and asymptomatic infection may persist for months before being cleared by an immune response.
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Medrano FJ, Montes-Cano M, Conde M, de la Horra C, Respaldiza N, Gasch A, et al. (February 2005).
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isolates from human lung tissue. For example, in one outbreak of 12 cases among transplant patients in
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Cushion MT (December 1998). "Taxonomy, genetic organization, and life cycle of Pneumocystis carinii".
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infection, it was widely accepted that this name could continue to be used, as it could now stand for
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pneumonia ; pneumocystosis; pneumocystiasis; interstitial plasma cell pneumonia; plasma cell pneumonia
4263: 4215: 4203: 4017: 3975: 3574: 3315: 3305: 3119: 3016: 3011: 2875: 2798: 2737: 623: 445: 173: 1393:"Supplementary Information: Microscopic appearance of Pneumocystis jiroveci from bronchial washings" 4531: 4498: 4244: 4193: 3821: 3641: 3508: 3427: 3155: 3147: 2981: 2573: 2231: 1396: 814: 1570:"X-linked hyper IgM syndrome with severe eosinophilia: a case report and review of the literature" 558:(a part of the cell wall of many different types of fungi) can also help in the diagnosis of PCP. 301:(ARDS) may occur in patients with severe Pneumocystis pneumonia, and such individuals may require 4587: 4389: 4254: 4210: 4042: 3963: 3890: 3760: 3339: 3321: 3137: 3133: 3050: 3043: 3001: 2747: 1704: 1325: 1274: 1206: 1096: 1073: 710: 531: 509: 398: 322: 95: 720:
pneumonia has been described in all continents except Antarctica. More than 75% of children are
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Morris A, Lundgren JD, Masur H, Walzer PD, Hanson DL, Frederick T, et al. (October 2004).
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Duboucher C, Boggia R, Morel G, Capron M, Pierce RJ, Dei-Cas E, Viscogliosi E (December 2007).
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Schmoldt S, Schuhegger R, Wendler T, Huber I, Söllner H, Hogardt M, et al. (March 2008).
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Puzio J, Kucewicz E, Sioła M, Dworniczak A, Wojarski J, Zegleń S, et al. (2009). "".
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pneumonia among homosexual male residents of Los Angeles and Range Counties, California"
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X-ray and CT of ground glass opacities and pneumothorax in pneumocystis pneumonia.
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Allen CM, Al-Jahdali HH, Irion KL, Al Ghanem S, Gouda A, Khan AN (October 2010).
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by the age of four, which suggests a high background exposure to the organism. A
475:(HRCT) showing ground-glass attenuation with a geographic or mosaic distribution. 4541: 4488: 4471: 4466: 4419: 4374: 4225: 4173: 4140: 4012: 3741: 3673: 3636: 3591: 3526: 3236: 3090: 2951: 2907: 2818: 2608: 2277: 1897: 793:. It was then known as plasma cellular interstitial pneumonitis of the newborn. 762: 631: 627: 603: 583: 571: 555: 429: 394: 357: 177: 153: 118: 99: 2258: 1974:
Sternberg SD, Rosenthal JH (April 1955). "Interstitial plasma cell pneumonia".
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Signs and symptoms may develop over several days or weeks and may include:
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Cushion MT (May 2004). "Pneumocystis: unraveling the cloak of obscurity".
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Riedel S, Hobden JA, Miller S, Morse SA, Mietzner TA, Detrick B (2019).
1194: 825:" and "group A streptococcus" are both valid.) Synonyms for PCP include 3789: 3665: 2812: 2699: 2693: 2688: 2353: 2348: 2336: 611: 410: 393:
The diagnosis can be confirmed by the characteristic appearance of the
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species that is found in rats) is still in common usage. As a result,
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pneumonia were described in premature infants in Europe following the
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is less often used, as its major limitation is the high frequency of
329:, which can be fatal if not treated aggressively. In this situation, 267: 263: 212: 2066:(9th ed.). New York: Arnold and Oxford Press. pp. 645–683. 234:
or other predisposing health conditions. PCP is seen in people with
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in lung fluids does not mean that a person has PCP or infection by
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is a well-known complication of PCP. Also, a condition similar to
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Stringer JR, Beard CB, Miller RF, Wakefield AE (September 2002).
2011:"A new name (Pneumocystis jiroveci) for Pneumocystis from humans" 2009:
Stringer JR, Beard CB, Miller RF, Wakefield AE (September 2002).
1924:"Update on the diagnosis and treatment of Pneumocystis pneumonia" 405:) that is strikingly lower than would be expected from symptoms. 3656: 2385: 753: 655: 513: 3481: 2309: 1467:
Stern A, Green H, Paul M, Vidal L, Leibovici L (October 2014).
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of the specimen, and more recently by molecular analysis of
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The causative organism of PCP is distributed worldwide and
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of increased opacification (whiteness) in the lower lungs.
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Topley and Wilson's Microbiology and Microbial Infections
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Fannin S, Gottlieb MS, Weisman JD, et al. (1982).
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These chest radiographs are of two patients. Both show
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Jawetz, Melnick & Adelberg's Medical Microbiology
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Antipneumocystic medication is used with concomitant
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In these 1928:Therapeutic Advances in Respiratory Disease 1917: 1915: 1473:The Cochrane Database of Systematic Reviews 4424: 4178: 4164: 3969: 3832: 3532: 3500: 3486: 3478: 3242: 2724: 2713: 2704: 2414: 2399: 2390: 2328: 2314: 2306: 2190: 1279:: CS1 maint: location missing publisher ( 1124: 1122: 1120: 1118: 1116: 928: 926: 924: 922: 920: 918: 916: 709:pneumonia are also common in infants with 70: 38: 4100:Combined pulmonary fibrosis and emphysema 2553:Trichophyton interdigitale/mentagrophytes 2164: 2034: 1947: 1832: 1788: 1747: 1655: 1603: 1585: 1492: 1443: 1368: 1311: 1156: 1146: 1131:"Imaging lung manifestations of HIV/AIDS" 875:Regarding nomenclature, when the name of 460:X-ray of a cyst in pneumocystis pneumonia 254:, dry/non-productive cough, weight loss, 1568:Li H, Cao Y, Ma J, Li C (4 April 2022). 939:Dorland's Illustrated Medical Dictionary 4124:Allergic bronchopulmonary aspergillosis 3107:Allergic bronchopulmonary aspergillosis 2791:Progressive disseminated histoplasmosis 1922:Carmona EM, Limper AH (February 2011). 912: 419: 1272: 1183:AJR. American Journal of Roentgenology 961: 959: 957: 955: 953: 951: 949: 352:In addition, in symptomatic cases of 7: 3022:Erosio interdigitalis blastomycetica 2762:Primary pulmonary coccidioidomycosis 2758:Primary cutaneous coccidioidomycosis 1171:Creative Commons Attribution License 1091: 1089: 1087: 1029:Bennett NJ, Gilroy SA (2017-08-08). 4557:Idiopathic pulmonary haemosiderosis 1886:The New England Journal of Medicine 1858:"A Cluster of Kaposi's Sarcoma and 705:and after surgery. Infections with 530:infection can also be diagnosed by 473:High-resolution computed tomography 299:acute respiratory distress syndrome 4146:Vaping-associated pulmonary injury 3509:Diseases of the respiratory system 2079:Seminars in Respiratory Infections 843:interstitial plasma cell pneumonia 586:inhalations may help prevent PCP. 25: 1543:Anestezjologia Intensywna Terapia 996:Infection, Genetics and Evolution 860:pneumonia (PCP) is also known as 364:. These parasites (including the 211:that is caused by the yeast-like 3007:Congenital cutaneous candidiasis 2786:Primary pulmonary histoplasmosis 2781:Primary cutaneous histoplasmosis 2488:Proximal subungual onychomycosis 1728:Journal of Clinical Microbiology 652:decreased white blood cell count 480: 465: 453: 437: 422: 3112:Primary cutaneous aspergillosis 2753:Disseminated coccidioidomycosis 2478:White superficial onychomycosis 1251:(28th ed.). New York, NY. 852:(which now applies only to the 313:The risk of PCP increases when 4562:Pulmonary alveolar proteinosis 2483:Distal subungual onychomycosis 1516:Ryan KJ, Ray CG, eds. (2004). 1485:10.1002/14651858.CD005590.pub3 1: 4136:Idiopathic pulmonary fibrosis 2827:Paracoccidioides brasiliensis 1988:10.1016/S0022-3476(55)80142-4 1790:10.1016/S1286-4579(01)01514-3 1520:(4th ed.). McGraw Hill. 879:pneumonia (PCP) changed from 695:immunosuppressive medications 600:trimethoprim/sulfamethoxazole 576:trimethoprim/sulfamethoxazole 4119:Respiratory hypersensitivity 4057:Hypersensitivity pneumonitis 3375:Encephalitozoon intestinalis 2868:South American blastomycosis 2863:North American blastomycosis 2468:Tinea pedis (athlete's foot) 2145:Emerging Infectious Diseases 2058:Cushion MT (1998). "Ch. 34: 2015:Emerging Infectious Diseases 1821:Clinical Infectious Diseases 1681:Clinical Infectious Diseases 1636:Emerging Infectious Diseases 1518:Sherris Medical Microbiology 1424:Emerging Infectious Diseases 1300:Nature Reviews. Microbiology 1050:Clinical Infectious Diseases 1008:10.1016/j.meegid.2008.05.001 496:(lung rinse). Staining with 18:Pneumocystis pneumonia (PCP) 4028:Coalworker's pneumoconiosis 3447:Granuloma gluteale infantum 2473:Tinea unguium/onychomycosis 1898:10.1056/NEJM198112103052402 1135:Annals of Thoracic Medicine 703:bone marrow transplantation 699:solid organ transplantation 626:(under investigation), and 4619: 3881:Acute exacerbation of COPD 2495:Tinea corporis gladiatorum 1587:10.1186/s12887-022-03251-z 1361:10.1016/j.jinf.2020.11.038 1343:Duboucher C (March 2021). 506:periodic acid-Schiff stain 28: 3283:Syncephalastrum racemosum 2118:10.1016/j.tim.2004.03.005 1976:The Journal of Pediatrics 1224:Bennett NJ (2017-08-08). 540:polymerase chain reaction 512:shows the characteristic 325:, leading to significant 78: 69: 3944:Diffuse panbronchiolitis 3937:Bronchiolitis obliterans 3803:Laryngotracheal stenosis 3750:Laryngopharyngeal reflux 3728:Laryngopharyngeal reflux 3686:Laryngopharyngeal reflux 3614:Nasal septum perforation 3290:Apophysomyces variabilis 2852:Blastomyces dermatitidis 2567:Trichophyton schoenleini 2532:Epidermophyton floccosum 1940:10.1177/1753465810380102 1349:The Journal of Infection 1097:"Pneumocystis Pneumonia" 510:immunofluorescence assay 135:Other types of pneumonia 53:Pneumocystis pneumonia; 29:Not to be confused with 3692:Retropharyngeal abscess 3371:Enterocytozoon bieneusi 3334:Conidiobolus incongruus 3276:Lichtheimia corymbifera 3201:Cryptococcus neoformans 3170:Pseudallescheria boydii 2659:Malassezia folliculitis 2581:Trichophyton verrucosum 1148:10.4103/1817-1737.69106 848:The older species name 752:Since the start of the 640:pancreatic inflammation 343:hyperventilatory effort 228:opportunistic infection 4583:Animal fungal diseases 4385:Pulmonary hypertension 4114:Eosinophilic pneumonia 3766:Vocal cord dysfunction 3609:Nasal septum deviation 3399:Rhinosporidium seeberi 3330:Conidiobolus coronatus 3069:Pneumocystis pneumonia 3058:Pneumocystis jirovecii 2987:Candidal onychomycosis 2977:Antibiotic candidiasis 2833:Paracoccidioidomycosis 2805:African histoplasmosis 2770:Histoplasma capsulatum 2742:Coccidioides posadasii 2560:Trichophyton tonsurans 2157:10.3201/eid0809.020096 2106:Trends in Microbiology 2027:10.3201/eid0809.020096 1777:Microbes and Infection 1648:10.3201/eid1010.030985 1436:10.3201/eid1102.040487 1313:10.1038/nrmicro1621-c1 817:correct; one uses the 811:pneumocystis pneumonia 686: 684:Pneumocystis jirovecii 638:. These include acute 536:histochemical staining 494:bronchoalveolar lavage 446:ground glass opacities 291: 217:Pneumocystis jirovecii 199:Pneumocystis jirovecii 131:Differential diagnosis 124:Weakened immune system 111:Pneumocystis jirovecii 84:Toluidine blue O stain 80:Pneumocystis jirovecii 55:Pneumocystis jirovecii 31:Pneumococcal pneumonia 4512:Mediastinal emphysema 4291:Healthcare-associated 4221:Legionnaires' disease 3647:Peritonsillar abscess 3619:Nasal septal hematoma 3142:Phialophora verrucosa 2972:Chronic mucocutaneous 2890:Talaromyces marneffei 2546:Microsporum audouinii 866:and (incorrectly) as 862:Pneumocystis jiroveci 682: 574:with co-trimoxazole ( 399:arterial oxygen level 382:Tritrichomonas foetus 376:Trichomonas vaginalis 341:) levels, stimulates 331:lactate dehydrogenase 289: 59:Pneumocystis jiroveci 4259:Mendelson's syndrome 4131:Hamman–Rich syndrome 3316:Basidiobolus ranarum 3306:Entomophthoramycosis 3120:Exophiala jeanselmei 3017:Systemic candidiasis 3012:Perianal candidiasis 2876:Sporothrix schenckii 2799:Histoplasma duboisii 2738:Coccidioides immitis 2060:Pneumocystis carinii 1860:Pneumocystis carinii 1740:10.1128/JCM.02016-07 868:Pneumocystis carinii 850:Pneumocystis carinii 675:Current epidemiology 624:pafuramidine maleate 250:(of gradual onset), 174:pafuramidine maleate 63:Pneumocystis carinii 4598:Atypical pneumonias 4532:Respiratory failure 4499:Mediastinal disease 4067:Bird fancier's lung 3642:Adenoid hypertrophy 3428:Fungal folliculitis 3156:Geotrichum candidum 3148:Chromoblastomycosis 2992:Candidal paronychia 2982:Candidal intertrigo 2574:Trichophyton rubrum 1195:10.2214/AJR.11.7329 785:The first cases of 542:products comparing 315:CD4-positive T-cell 4437:Pleuritis/pleurisy 4390:Pulmonary embolism 4286:Community-acquired 4211:Atypical bacterial 4110:Löffler's syndrome 3891:Status asthmaticus 3876:Chronic bronchitis 3761:Vocal fold paresis 3575:Vasomotor rhinitis 3340:Conidiobolomycosis 3322:Basidiobolomycosis 3138:Fonsecaea compacta 3134:Fonsecaea pedrosoi 3002:Diaper candidiasis 2748:Coccidioidomycosis 2269:External resources 711:hyper IgM syndrome 687: 349:(breathlessness). 345:, thereby causing 292: 242:Signs and symptoms 232:weak immune system 96:Infectious disease 4570: 4569: 4520: 4519: 4477:Empyema/pyothorax 4409: 4408: 4405: 4404: 4363: 4362: 4296:Hospital-acquired 4154: 4153: 4018:Caplan's syndrome 3811: 3810: 3756:Vocal fold nodule 3580:Atrophic rhinitis 3475: 3474: 3467:Phaeohyphomycosis 3452:Hyalohyphomycosis 3384: 3383: 3350: 3349: 3186: 3185: 2930: 2929: 2683: 2682: 2648:Malassezia furfur 2633: 2632: 2603:Hortaea werneckii 2590: 2589: 2539:Microsporum canis 2303: 2302: 1892:(24): 1431–1438. 1642:(10): 1713–1720. 1527:978-0-8385-8529-0 568:immunocompromised 532:immunofluorescent 370:Trichomonas tenax 196:), also known as 184: 183: 36:Medical condition 16:(Redirected from 4610: 4455:Pleural effusion 4448:Hemopneumothorax 4425: 4179: 4165: 4008:Bauxite fibrosis 3973:External agents/ 3970: 3901:Exercise-induced 3857:Acute bronchitis 3833: 3533: 3502: 3495: 3488: 3479: 3405:Rhinosporidiosis 3361:Microsporidiosis 3301:Entomophthorales 3243: 3220:Trichosporonosis 2946:Candida albicans 2920:Adiaspiromycosis 2725: 2714: 2705: 2654:Tinea versicolor 2415: 2400: 2391: 2337:Fungal infection 2330: 2323: 2316: 2307: 2191: 2179: 2178: 2168: 2136: 2130: 2129: 2101: 2095: 2094: 2074: 2068: 2067: 2055: 2049: 2048: 2038: 2006: 2000: 1999: 1971: 1962: 1961: 1951: 1919: 1910: 1909: 1880: 1874: 1873: 1853: 1847: 1846: 1836: 1827:(9): 1143–1149. 1818: 1809: 1803: 1802: 1792: 1768: 1762: 1761: 1751: 1719: 1713: 1712: 1676: 1670: 1669: 1659: 1627: 1618: 1617: 1607: 1589: 1565: 1559: 1558: 1538: 1532: 1531: 1513: 1507: 1506: 1496: 1479:(10): CD005590. 1464: 1458: 1457: 1447: 1415: 1409: 1408: 1406: 1404: 1395:. Archived from 1389: 1383: 1382: 1372: 1340: 1334: 1333: 1315: 1291: 1285: 1284: 1278: 1270: 1242: 1236: 1235: 1221: 1215: 1214: 1189:(6): W555–W561. 1178: 1172: 1170: 1160: 1150: 1126: 1111: 1110: 1108: 1107: 1093: 1082: 1081: 1045: 1039: 1038: 1026: 1020: 1019: 991: 982: 981: 979: 978: 963: 944: 943: 930: 837:(pneumocystis + 829:(pneumocystis + 815:orthographically 791:Second World War 759:organ transplant 484: 469: 457: 441: 426: 407:Gallium 67 scans 360:) of the family 319:immunosuppressed 207:), is a form of 74: 39: 21: 4618: 4617: 4613: 4612: 4611: 4609: 4608: 4607: 4603:Fungal diseases 4573: 4572: 4571: 4566: 4516: 4493: 4429:Pleural disease 4418: 4401: 4359: 4321: 4305:By distribution 4300: 4279:By vector/route 4274: 4172: 4160: 4150: 4105:Pulmonary edema 4083: 3978: 3974: 3961: 3957: 3948: 3913:Cystic fibrosis 3840: 3824: 3820: 3807: 3651: 3525: 3519: 3511: 3506: 3476: 3471: 3411: 3380: 3358: 3346: 3303: 3295: 3262:Rhizopus oryzae 3249: 3234: 3226: 3182: 3075: 2926: 2839: 2720: 2697: 2692: 2679: 2629: 2617:Piedraia hortae 2586: 2519: 2510:Tinea incognito 2505:Tinea imbricata 2409:Dermatophytosis 2406: 2380: 2371: 2362: 2356: 2352: 2343: 2334: 2304: 2299: 2298: 2264: 2263: 2202: 2188: 2183: 2182: 2138: 2137: 2133: 2103: 2102: 2098: 2076: 2075: 2071: 2057: 2056: 2052: 2008: 2007: 2003: 1973: 1972: 1965: 1921: 1920: 1913: 1882: 1881: 1877: 1855: 1854: 1850: 1816: 1811: 1810: 1806: 1770: 1769: 1765: 1721: 1720: 1716: 1678: 1677: 1673: 1629: 1628: 1621: 1567: 1566: 1562: 1540: 1539: 1535: 1528: 1515: 1514: 1510: 1466: 1465: 1461: 1417: 1416: 1412: 1402: 1400: 1399:on 18 July 2009 1391: 1390: 1386: 1342: 1341: 1337: 1293: 1292: 1288: 1271: 1259: 1244: 1243: 1239: 1223: 1222: 1218: 1180: 1179: 1175: 1128: 1127: 1114: 1105: 1103: 1095: 1094: 1085: 1047: 1046: 1042: 1028: 1027: 1023: 993: 992: 985: 976: 974: 965: 964: 947: 932: 931: 914: 909: 835:pneumocystiasis 803: 783: 750: 677: 672: 664:low blood sugar 592: 564: 488: 485: 476: 470: 461: 458: 449: 442: 433: 427: 415:pulmonary cysts 404: 391: 362:Trichomonadidae 340: 311: 309:Pathophysiology 284: 244: 37: 34: 23: 22: 15: 12: 11: 5: 4616: 4614: 4606: 4605: 4600: 4595: 4590: 4585: 4575: 4574: 4568: 4567: 4565: 4564: 4559: 4554: 4549: 4544: 4539: 4534: 4528: 4526: 4522: 4521: 4518: 4517: 4515: 4514: 4509: 4503: 4501: 4495: 4494: 4492: 4491: 4485: 4484: 4479: 4474: 4469: 4464: 4459: 4457: 4451: 4450: 4440: 4439: 4433: 4431: 4422: 4415:Pleural cavity 4411: 4410: 4407: 4406: 4403: 4402: 4400: 4399: 4394: 4393: 4392: 4387: 4377: 4371: 4369: 4365: 4364: 4361: 4360: 4358: 4357: 4352: 4347: 4342: 4337: 4331: 4329: 4323: 4322: 4320: 4319: 4314: 4308: 4306: 4302: 4301: 4299: 4298: 4293: 4288: 4282: 4280: 4276: 4275: 4273: 4272: 4271: 4270: 4261: 4247: 4242: 4241: 4240: 4230: 4229: 4228: 4223: 4218: 4208: 4207: 4206: 4201: 4191: 4185: 4183: 4176: 4162: 4156: 4155: 4152: 4151: 4149: 4148: 4143: 4138: 4133: 4128: 4127: 4126: 4116: 4107: 4102: 4097: 4091: 4089: 4085: 4084: 4082: 4081: 4080: 4079: 4077:Lycoperdonosis 4074: 4069: 4064: 4053: 4052: 4051: 4050: 4045: 4040: 4035: 4030: 4025: 4020: 4015: 4010: 4005: 4000: 3995: 3988:Pneumoconiosis 3984: 3982: 3967: 3950: 3949: 3947: 3946: 3941: 3940: 3939: 3929: 3924: 3922: 3916: 3915: 3910: 3908:Bronchiectasis 3905: 3904: 3903: 3898: 3893: 3884: 3878: 3868: 3866: 3860: 3859: 3854: 3852: 3846: 3844: 3830: 3813: 3812: 3809: 3808: 3806: 3805: 3800: 3795: 3793: 3785: 3784: 3779: 3777: 3769: 3768: 3763: 3758: 3753: 3747: 3745: 3737: 3736: 3731: 3725: 3720: 3718:Laryngeal cyst 3715: 3713:Laryngomalacia 3710: 3705: 3703: 3695: 3694: 3689: 3683: 3682: 3681: 3671: 3669: 3661: 3659: 3653: 3652: 3650: 3649: 3644: 3639: 3634: 3632: 3624: 3623: 3622: 3621: 3616: 3611: 3599: 3594: 3589: 3588: 3587: 3582: 3577: 3567: 3565: 3557: 3556: 3551: 3549: 3541: 3539: 3530: 3513: 3512: 3507: 3505: 3504: 3497: 3490: 3482: 3473: 3472: 3470: 3469: 3464: 3459: 3454: 3449: 3444: 3443: 3442: 3430: 3425: 3419: 3417: 3413: 3412: 3410: 3409: 3408: 3407: 3394: 3392: 3390:Mesomycetozoea 3386: 3385: 3382: 3381: 3379: 3378: 3366: 3364: 3352: 3351: 3348: 3347: 3345: 3344: 3343: 3342: 3326: 3325: 3324: 3311: 3309: 3297: 3296: 3294: 3293: 3286: 3279: 3272: 3265: 3257: 3255: 3240: 3228: 3227: 3225: 3224: 3223: 3222: 3217: 3209: 3207:Cryptococcosis 3196: 3194: 3188: 3187: 3184: 3183: 3181: 3180: 3179: 3178: 3176:Allescheriasis 3166: 3165: 3164: 3152: 3151: 3150: 3130: 3129: 3128: 3116: 3115: 3114: 3109: 3104: 3099: 3086: 3084: 3077: 3076: 3074: 3073: 3072: 3071: 3066: 3064:Pneumocystosis 3054: 3047: 3040: 3033: 3026: 3025: 3024: 3019: 3014: 3009: 3004: 2999: 2994: 2989: 2984: 2979: 2974: 2969: 2964: 2959: 2954: 2941: 2939: 2932: 2931: 2928: 2927: 2925: 2924: 2923: 2922: 2914:Emmonsia parva 2910: 2905: 2903:Scedosporiosis 2900: 2899: 2898: 2886: 2885: 2884: 2882:Sporotrichosis 2872: 2871: 2870: 2865: 2860: 2847: 2845: 2841: 2840: 2838: 2837: 2836: 2835: 2823: 2822: 2821: 2809: 2808: 2807: 2795: 2794: 2793: 2788: 2783: 2778: 2776:Histoplasmosis 2766: 2765: 2764: 2755: 2750: 2733: 2731: 2722: 2711: 2702: 2685: 2684: 2681: 2680: 2678: 2677: 2676: 2675: 2663: 2662: 2661: 2656: 2643: 2641: 2635: 2634: 2631: 2630: 2628: 2627: 2626: 2625: 2613: 2612: 2611: 2598: 2596: 2592: 2591: 2588: 2587: 2585: 2584: 2577: 2570: 2563: 2556: 2549: 2542: 2535: 2527: 2525: 2521: 2520: 2518: 2517: 2512: 2507: 2502: 2497: 2492: 2491: 2490: 2485: 2480: 2470: 2465: 2460: 2455: 2454: 2453: 2451:Dermatophytids 2448: 2441:Tinea corporis 2438: 2437: 2436: 2421: 2419: 2412: 2397: 2388: 2359:dermatomycosis 2345: 2344: 2341:mesomycetozoea 2335: 2333: 2332: 2325: 2318: 2310: 2301: 2300: 2297: 2296: 2285: 2273: 2272: 2270: 2266: 2265: 2262: 2261: 2250: 2239: 2224: 2203: 2198: 2197: 2195: 2194:Classification 2187: 2186:External links 2184: 2181: 2180: 2151:(9): 891–896. 2131: 2112:(5): 243–249. 2096: 2085:(4): 304–312. 2069: 2050: 2021:(9): 891–896. 2001: 1982:(4): 380–393. 1963: 1911: 1875: 1848: 1834:10.1086/513198 1804: 1763: 1734:(3): 966–971. 1714: 1693:10.1086/649868 1687:(3): 347–353. 1671: 1619: 1574:BMC Pediatrics 1560: 1533: 1526: 1508: 1459: 1430:(2): 245–250. 1410: 1384: 1355:(3): e22–e23. 1335: 1286: 1257: 1237: 1216: 1173: 1141:(4): 201–216. 1112: 1083: 1062:10.1086/649868 1056:(3): 347–353. 1040: 1021: 1002:(5): 708–726. 983: 945: 911: 910: 908: 905: 827:pneumocystosis 809:pneumonia and 802: 799: 782: 779: 771:co-trimoxazole 749: 746: 691:immune systems 676: 673: 671: 668: 648:liver toxicity 644:kidney failure 591: 588: 563: 560: 498:toluidine blue 490: 489: 486: 479: 477: 471: 464: 462: 459: 452: 450: 443: 436: 434: 428: 421: 402: 390: 387: 338: 335:carbon dioxide 310: 307: 283: 280: 279: 278: 243: 240: 182: 181: 146:co-trimoxazole 143: 137: 136: 133: 127: 126: 121: 115: 114: 107: 103: 102: 93: 87: 86: 76: 75: 67: 66: 51: 47: 46: 35: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4615: 4604: 4601: 4599: 4596: 4594: 4591: 4589: 4586: 4584: 4581: 4580: 4578: 4563: 4560: 4558: 4555: 4553: 4550: 4548: 4545: 4543: 4540: 4538: 4535: 4533: 4530: 4529: 4527: 4525:Other/general 4523: 4513: 4510: 4508: 4507:Mediastinitis 4505: 4504: 4502: 4500: 4496: 4490: 4487: 4486: 4483: 4480: 4478: 4475: 4473: 4470: 4468: 4465: 4463: 4460: 4458: 4456: 4453: 4452: 4449: 4445: 4442: 4441: 4438: 4435: 4434: 4432: 4430: 4426: 4423: 4421: 4416: 4412: 4398: 4395: 4391: 4388: 4386: 4383: 4382: 4381: 4378: 4376: 4373: 4372: 4370: 4366: 4356: 4353: 4351: 4348: 4346: 4343: 4341: 4338: 4336: 4333: 4332: 4330: 4328: 4324: 4318: 4315: 4313: 4310: 4309: 4307: 4303: 4297: 4294: 4292: 4289: 4287: 4284: 4283: 4281: 4277: 4269: 4265: 4262: 4260: 4256: 4253: 4252: 4251: 4250:noninfectious 4248: 4246: 4243: 4239: 4236: 4235: 4234: 4231: 4227: 4224: 4222: 4219: 4217: 4214: 4213: 4212: 4209: 4205: 4202: 4200: 4197: 4196: 4195: 4192: 4190: 4187: 4186: 4184: 4180: 4177: 4175: 4170: 4166: 4163: 4159:Obstructive / 4157: 4147: 4144: 4142: 4139: 4137: 4134: 4132: 4129: 4125: 4122: 4121: 4120: 4117: 4115: 4111: 4108: 4106: 4103: 4101: 4098: 4096: 4093: 4092: 4090: 4086: 4078: 4075: 4073: 4072:Farmer's lung 4070: 4068: 4065: 4063: 4060: 4059: 4058: 4055: 4054: 4049: 4046: 4044: 4041: 4039: 4036: 4034: 4031: 4029: 4026: 4024: 4021: 4019: 4016: 4014: 4011: 4009: 4006: 4004: 4001: 3999: 3996: 3994: 3991: 3990: 3989: 3986: 3985: 3983: 3981: 3977: 3971: 3968: 3965: 3960: 3955: 3951: 3945: 3942: 3938: 3935: 3934: 3933: 3932:Bronchiolitis 3930: 3928: 3925: 3923: 3921: 3918: 3917: 3914: 3911: 3909: 3906: 3902: 3899: 3897: 3894: 3892: 3888: 3885: 3882: 3879: 3877: 3874: 3873: 3872: 3869: 3867: 3865: 3862: 3861: 3858: 3855: 3853: 3851: 3848: 3847: 3845: 3843: 3838: 3834: 3831: 3828: 3823: 3818: 3814: 3804: 3801: 3799: 3796: 3794: 3792: 3791: 3787: 3786: 3783: 3780: 3778: 3776: 3775: 3771: 3770: 3767: 3764: 3762: 3759: 3757: 3754: 3751: 3748: 3746: 3744: 3743: 3739: 3738: 3735: 3732: 3729: 3726: 3724: 3721: 3719: 3716: 3714: 3711: 3709: 3706: 3704: 3702: 3701: 3697: 3696: 3693: 3690: 3687: 3684: 3680: 3677: 3676: 3675: 3672: 3670: 3668: 3667: 3663: 3662: 3660: 3658: 3654: 3648: 3645: 3643: 3640: 3638: 3635: 3633: 3631: 3630: 3626: 3625: 3620: 3617: 3615: 3612: 3610: 3607: 3606: 3605: 3604: 3600: 3598: 3595: 3593: 3590: 3586: 3583: 3581: 3578: 3576: 3573: 3572: 3571: 3568: 3566: 3564: 3563: 3559: 3558: 3555: 3552: 3550: 3548: 3547: 3543: 3542: 3540: 3538: 3534: 3531: 3528: 3523: 3518: 3514: 3510: 3503: 3498: 3496: 3491: 3489: 3484: 3483: 3480: 3468: 3465: 3463: 3462:Keratomycosis 3460: 3458: 3455: 3453: 3450: 3448: 3445: 3441: 3438: 3437: 3436: 3435: 3431: 3429: 3426: 3424: 3423:Alternariosis 3421: 3420: 3418: 3414: 3406: 3403: 3402: 3401: 3400: 3396: 3395: 3393: 3391: 3387: 3377: 3376: 3372: 3368: 3367: 3365: 3362: 3357: 3356:Microsporidia 3353: 3341: 3338: 3337: 3336: 3335: 3331: 3327: 3323: 3320: 3319: 3318: 3317: 3313: 3312: 3310: 3307: 3302: 3298: 3292: 3291: 3287: 3285: 3284: 3280: 3278: 3277: 3273: 3271: 3270: 3269:Mucor indicus 3266: 3264: 3263: 3259: 3258: 3256: 3253: 3248: 3244: 3241: 3238: 3233: 3229: 3221: 3218: 3215: 3214: 3210: 3208: 3205: 3204: 3203: 3202: 3198: 3197: 3195: 3193: 3192:Basidiomycota 3189: 3177: 3174: 3173: 3172: 3171: 3167: 3163: 3160: 3159: 3158: 3157: 3153: 3149: 3146: 3145: 3144: 3143: 3139: 3135: 3131: 3127: 3124: 3123: 3122: 3121: 3117: 3113: 3110: 3108: 3105: 3103: 3100: 3098: 3097:Aspergillosis 3095: 3094: 3093: 3092: 3088: 3087: 3085: 3082: 3078: 3070: 3067: 3065: 3062: 3061: 3060: 3059: 3055: 3053: 3052: 3051:C. tropicalis 3048: 3046: 3045: 3044:C. lusitaniae 3041: 3039: 3038: 3034: 3032: 3031: 3027: 3023: 3020: 3018: 3015: 3013: 3010: 3008: 3005: 3003: 3000: 2998: 2995: 2993: 2990: 2988: 2985: 2983: 2980: 2978: 2975: 2973: 2970: 2968: 2965: 2963: 2960: 2958: 2955: 2953: 2950: 2949: 2948: 2947: 2943: 2942: 2940: 2937: 2933: 2921: 2918: 2917: 2916: 2915: 2911: 2909: 2906: 2904: 2901: 2897: 2896:Talaromycosis 2894: 2893: 2892: 2891: 2887: 2883: 2880: 2879: 2878: 2877: 2873: 2869: 2866: 2864: 2861: 2859: 2858:Blastomycosis 2856: 2855: 2854: 2853: 2849: 2848: 2846: 2842: 2834: 2831: 2830: 2829: 2828: 2824: 2820: 2817: 2816: 2815: 2814: 2813:Lacazia loboi 2810: 2806: 2803: 2802: 2801: 2800: 2796: 2792: 2789: 2787: 2784: 2782: 2779: 2777: 2774: 2773: 2772: 2771: 2767: 2763: 2759: 2756: 2754: 2751: 2749: 2746: 2745: 2744: 2743: 2739: 2735: 2734: 2732: 2730: 2726: 2723: 2719: 2715: 2712: 2710: 2706: 2703: 2701: 2700:opportunistic 2695: 2690: 2686: 2674: 2671: 2670: 2669: 2668: 2664: 2660: 2657: 2655: 2652: 2651: 2650: 2649: 2645: 2644: 2642: 2640: 2639:Basidiomycota 2636: 2624: 2621: 2620: 2619: 2618: 2614: 2610: 2607: 2606: 2605: 2604: 2600: 2599: 2597: 2593: 2583: 2582: 2578: 2576: 2575: 2571: 2569: 2568: 2564: 2562: 2561: 2557: 2555: 2554: 2550: 2548: 2547: 2543: 2541: 2540: 2536: 2534: 2533: 2529: 2528: 2526: 2522: 2516: 2513: 2511: 2508: 2506: 2503: 2501: 2498: 2496: 2493: 2489: 2486: 2484: 2481: 2479: 2476: 2475: 2474: 2471: 2469: 2466: 2464: 2461: 2459: 2456: 2452: 2449: 2447: 2444: 2443: 2442: 2439: 2435: 2432: 2431: 2430: 2429:tinea capitis 2426: 2423: 2422: 2420: 2416: 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265: 261: 257: 253: 249: 241: 239: 237: 233: 229: 225: 221: 219: 218: 214: 210: 206: 202: 200: 195: 191: 189: 179: 175: 171: 167: 163: 159: 155: 151: 147: 144: 142: 138: 134: 132: 128: 125: 122: 120: 116: 113: 112: 108: 104: 101: 97: 94: 92: 88: 85: 81: 77: 73: 68: 64: 60: 56: 52: 48: 44: 40: 32: 27: 19: 4444:Pneumothorax 4397:Lung abscess 4379: 4249: 4238:Pneumocystis 4237: 4199:Pneumococcal 3980:lung disease 3976:occupational 3954:Interstitial 3919: 3863: 3849: 3822:lung disease 3788: 3782:Epiglottitis 3772: 3740: 3734:Laryngospasm 3698: 3679:Strep throat 3664: 3627: 3603:nasal septum 3601: 3560: 3544: 3432: 3397: 3369: 3328: 3314: 3288: 3281: 3274: 3267: 3260: 3252:Mucormycosis 3213:Trichosporon 3211: 3199: 3168: 3162:Geotrichosis 3154: 3132: 3118: 3102:Aspergilloma 3089: 3068: 3056: 3049: 3042: 3035: 3028: 2967:Vulvovaginal 2944: 2912: 2888: 2874: 2850: 2825: 2811: 2797: 2768: 2736: 2721:(yeast+mold) 2689:Subcutaneous 2673:White piedra 2667:Trichosporon 2665: 2646: 2623:Black piedra 2615: 2601: 2579: 2572: 2565: 2558: 2551: 2544: 2537: 2530: 2500:Tinea faciei 2463:Tinea manuum 2458:Tinea cruris 2425:Tinea barbae 2404:Dermatophyte 2287: 2276: 2252: 2241: 2226: 2206: 2148: 2144: 2134: 2109: 2105: 2099: 2082: 2078: 2072: 2063: 2059: 2053: 2018: 2014: 2004: 1979: 1975: 1934:(1): 41–59. 1931: 1927: 1889: 1885: 1878: 1872:(32): 305–7. 1869: 1865: 1859: 1851: 1824: 1820: 1807: 1780: 1776: 1766: 1731: 1727: 1717: 1684: 1680: 1674: 1639: 1635: 1577: 1573: 1563: 1549:(1): 41–45. 1546: 1542: 1536: 1517: 1511: 1476: 1472: 1462: 1427: 1423: 1413: 1401:. 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4182:By pathogen 4174:pneumonitis 4161:Restrictive 4141:Sarcoidosis 4013:Berylliosis 3959:restrictive 3920:unspecified 3842:obstructive 3825:(including 3742:vocal cords 3674:Pharyngitis 3637:Tonsillitis 3592:Nasal polyp 3527:common cold 3520:(including 3237:Zygomycosis 3091:Aspergillus 3037:C. glabrata 2952:Candidiasis 2908:Emmonsiosis 2819:Lobomycosis 2609:Tinea nigra 2524:By organism 2418:By location 2349:Superficial 2278:MedlinePlus 1866:MMWR Weekly 1306:(12): 967. 971:www.cdc.gov 942:, Elsevier. 763:pentamidine 726:post mortem 632:Pentamidine 628:clindamycin 604:pentamidine 584:pentamidine 572:prophylaxis 518:Histoplasma 430:Chest X-ray 395:chest X-ray 358:Parabasalia 178:clindamycin 154:pentamidine 100:Pulmonology 61:pneumonia; 57:pneumonia; 50:Other names 4577:Categories 4462:Hemothorax 4264:Aspiration 4226:Chlamydiae 4216:Mycoplasma 4204:Klebsiella 4062:Bagassosis 4048:Byssinosis 4023:Chalicosis 3998:Asbestosis 3993:Aluminosis 3927:Bronchitis 3798:Tracheitis 3774:epiglottis 3723:Laryngitis 3597:Rhinorrhea 3457:Otomycosis 3440:Fusariosis 3232:Zygomycota 3126:Eumycetoma 2962:Esophageal 2729:Onygenales 2709:Ascomycota 2395:Ascomycota 2254:DiseasesDB 1580:(1): 178. 1267:1101189928 1106:2020-08-10 977:2020-08-10 907:References 903:neumonia. 881:P. carinii 620:primaquine 616:atovaquone 580:atovaquone 562:Prevention 556:β-D-glucan 303:intubation 170:primaquine 166:atovaquone 141:Medication 4588:Pneumonia 4537:Influenza 4482:Malignant 4245:Parasitic 4194:Bacterial 4169:Pneumonia 4038:Silicosis 4033:Siderosis 4003:Baritosis 3837:Bronchial 3585:Hay fever 3554:Sinusitis 3416:Ungrouped 3247:Mucorales 2718:Dimorphic 2382:endothrix 2354:cutaneous 2289:eMedicine 1596:1471-2431 1275:cite book 870:pneumonia 864:pneumonia 590:Treatment 413:may show 389:Diagnosis 366:commensal 209:pneumonia 201:pneumonia 190:pneumonia 91:Specialty 45:pneumonia 4593:HIV/AIDS 4552:COVID-19 4345:BOOP-COP 4312:Broncho- 4255:Chemical 4043:Talcosis 3964:fibrosis 3817:Lower RT 3570:Rhinitis 3517:Upper RT 3434:Fusarium 3030:C. auris 2997:Candidid 2694:systemic 2446:Ringworm 2377:exothrix 2294:med/1850 2175:12194762 2126:15120144 2045:12194762 1996:14368443 1958:20736243 1843:17407029 1799:11825780 1758:18216217 1709:13097433 1701:20047487 1666:15504255 1614:35379217 1555:19517677 1503:25269391 1454:15752442 1379:33271170 1330:33897311 1322:19507333 1231:Medscape 1203:22623570 1167:20981180 1078:13097433 1070:20047487 1035:Medscape 1016:18565802 934:Elsevier 596:steroids 570:people, 508:, or an 236:HIV/AIDS 150:steroids 3864:chronic 3790:trachea 3666:pharynx 3546:sinuses 2248:D011020 2166:2732539 2091:9872627 2036:2732539 1949:6886706 1906:6975437 1749:2268360 1657:3323247 1605:8978371 1494:6457644 1445:3320436 1370:7834870 1211:7041746 1158:2954374 841:), and 781:History 612:dapsone 411:CT scan 397:and an 347:dyspnea 327:hypoxia 323:alveoli 162:dapsone 4233:Fungal 3887:Asthma 3700:larynx 3629:tonsil 2434:Kerion 2373:Piedra 2283:000671 2173:  2163:  2124:  2089:  2043:  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1754:PMID 1697:PMID 1662:PMID 1610:PMID 1592:ISSN 1551:PMID 1522:ISBN 1499:PMID 1450:PMID 1405:2009 1375:PMID 1318:PMID 1281:link 1263:OCLC 1253:ISBN 1199:PMID 1163:PMID 1066:PMID 1012:PMID 813:are 754:AIDS 656:rash 401:(PaO 379:and 176:and 4340:DIP 4335:UIP 4327:IIP 3216:spp 2351:and 2228:ICD 2217:B59 2208:ICD 2161:PMC 2153:doi 2114:doi 2031:PMC 2023:doi 1984:doi 1944:PMC 1936:doi 1894:doi 1890:305 1829:doi 1785:doi 1744:PMC 1736:doi 1689:doi 1652:PMC 1644:doi 1600:PMC 1582:doi 1489:PMC 1481:doi 1440:PMC 1432:doi 1365:PMC 1357:doi 1308:doi 1191:doi 1187:198 1153:PMC 1143:doi 1058:doi 1004:doi 833:), 775:CD4 701:or 578:), 566:In 552:HIV 544:DNA 534:or 520:or 337:(CO 270:). 205:PJP 194:PCP 98:, 4579:: 4355:RB 2760:. 2366:= 2361:): 2292:: 2281:: 2257:: 2246:: 2235:: 2219:† 2215:: 2212:10 2169:. 2159:. 2147:. 2143:. 2120:. 2110:12 2108:. 2083:13 2081:. 2039:. 2029:. 2017:. 2013:. 1990:. 1980:46 1978:. 1966:^ 1952:. 1942:. 1930:. 1926:. 1914:^ 1900:. 1888:. 1870:31 1868:. 1864:. 1837:. 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Index

Pneumocystis pneumonia (PCP)
Pneumococcal pneumonia

Toluidine blue O stain
Specialty
Infectious disease
Pulmonology
Pneumocystis jirovecii
Risk factors
Weakened immune system
Differential diagnosis
Medication
co-trimoxazole
steroids
pentamidine
trimetrexate
dapsone
atovaquone
primaquine
pafuramidine maleate
clindamycin
pneumonia
fungus
Pneumocystis jirovecii
opportunistic infection
weak immune system
HIV/AIDS
shortness of breath and/or difficulty breathing
fever
night sweats

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