737:
330:
and RNA localization. Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons. These studies also show that such a treatment can be applied to the substantia nigra of mice models of
Parkinson's disease in order to convert astrocytes to
695:
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552:
615:
771:
534:
538:
326:. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing,
681:
651:
807:
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764:
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340:
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419:"Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice"
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468:"Reversing a model of Parkinson's disease with in situ converted nigral neurons"
331:
dopaminergic neurons and as a consequence restore motor function in these mice.
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23:
362:"Post-transcriptional regulation: the dawn of PTB"
611:Cleavage and polyadenylation specificity factor
466:Qian H, Kang X, Hu J, et al. (June 2020).
417:Zhou H, Su J, Hu X, et al. (April 2020).
772:
560:
8:
602:hu paraneoplastic encephalomyelitis antigens
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567:
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136:
607:mRNA cleavage and polyadenylation factors
537:at the U.S. National Library of Medicine
499:
434:
385:
360:Valcárcel J, Gebauer F (November 1997).
352:
174:polypyrimidine tract binding protein 2
169:
25:polypyrimidine tract binding protein 1
20:
7:
733:
731:
672:polypyrimidine tract-binding protein
592:Fragile X mental retardation protein
535:polypyrimidine+tract-binding+protein
312:Polypyrimidine tract-binding protein
751:. You can help Knowledge (XXG) by
14:
735:
1:
387:10.1016/S0960-9822(06)00361-7
798:Genes on human chromosome 19
803:Genes on human chromosome 1
616:Cleavage stimulation factor
824:
730:
642:nuclear factor 90 proteins
587:Butyrate response factor 1
436:10.1016/j.cell.2020.03.024
582:
492:10.1038/s41586-020-2388-4
276:
135:
539:Medical Subject Headings
682:RNA cap-binding protein
652:Poly(A)-binding protein
747:-related article is a
622:host factor 1 protein
702:SMN complex proteins
576:RNA-binding proteins
341:Polypyrimidine tract
686:Cap binding complex
484:2020Natur.582..550Q
378:1997CBio....7R.705V
324:RNA-binding protein
429:(3): 590–603.e16.
760:
759:
725:
724:
677:ribonucleoprotein
478:(7813): 550–556.
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314:, also known as
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366:Current Biology
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529:External links
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372:(11): R705-8.
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328:mRNA stability
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16:Protein family
15:
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10:
9:
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4:
3:
2:
820:
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808:Protein stubs
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753:expanding it
742:
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127:
46:Alt. symbols
18:
290:Swiss-model
180:Identifiers
149:Swiss-model
31:Identifiers
792:Categories
347:References
286:Structures
281:Search for
270:p21.3-22.1
255:Other data
145:Structures
140:Search for
114:Other data
627:Aconitase
518:220051280
453:215514410
237:NM_021190
196:NCBI gene
96:NM_002819
55:NCBI gene
510:32581380
445:32272060
404:13820693
335:See also
322:, is an
300:InterPro
159:InterPro
745:protein
501:7521455
480:Bibcode
396:9382788
374:Bibcode
320:hnRNP I
296:Domains
244:UniProt
155:Domains
125:Chr. 19
103:UniProt
696:EIF4G1
666:PABPC4
661:PABPC3
656:PABPC1
541:(MeSH)
516:
508:
498:
472:Nature
451:
443:
402:
394:
266:Chr. 1
249:Q9UKA9
232:RefSeq
225:608449
185:Symbol
108:P26599
91:RefSeq
84:600693
36:Symbol
743:This
716:DDX20
691:EIF4E
514:S2CID
449:S2CID
400:S2CID
261:Locus
213:17662
201:58155
189:PTBP2
129:p13.3
120:Locus
40:PTBP1
749:stub
711:SMN2
706:SMN1
646:ILF2
636:ACO2
631:ACO1
506:PMID
441:PMID
423:Cell
392:PMID
220:OMIM
208:HGNC
79:OMIM
72:9583
67:HGNC
60:5725
597:Rev
496:PMC
488:doi
476:582
431:doi
427:181
382:doi
318:or
316:PTB
49:PTB
794::
512:.
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494:.
486:.
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364:.
780:e
773:t
766:v
755:.
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704:(
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684:(
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629:(
618:)
609:(
568:e
561:t
554:v
520:.
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384::
376::
370:7
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