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Post-mortem findings in suckling animals include empty stomach contents with little milk curd. The intestines are thin walled and distended, filled with a watery content. Diagnosis of PED is confirmed using PCR from feces or intestines of affected animals, or by immunohistochemistry on formalin-fixed
289:
A Bayesian study of 138 genomes showed that the virus has six subtypes. Groups 1 and 2 originated in North
America and groups 3–5 originated in Asia. The evolution rate of the genome was estimated to be 3.38 × 10 substitutions/site/year similar to other RNA viruses. The most recent common ancestor of
272:
in piglets. Morbidity and mortality rates were lower for vaccinated herds than for nonvaccinated herds, which suggests the emergence of a new PEDV field strain(s) for which the current vaccine, based on the CV777 strain, was partially protective. Consumers are likely to feel the effects of the viral
308:
PED is transmitted by fecal-oral transmission and the infectious dose is low. Pre-weaned piglets shed large amounts of virus in their feces resulting in rapid spread and high mortality rates. Older animals do not shed as much virus in their feces as piglets. It can also be spread via contaminated
298:
PED is an acute disease with an incubation period of 1-4 days. The virus causes diarrhea and vomiting resulting in severe dehydration. In neonates the mortality can be up to 100% in virulent strains. Older pigs generally recover in 7-10 days. Piglets when sick often lie in groups or lie on the
260:
in the winter of 2014. In
January 2014, a new variant strain of PEDV with three deletions, one insertion, and several mutations in S (spike) 1 region was identified in Ohio by the Animal Disease Diagnostic Lab of Ohio Department of Agriculture.
217:. Older hogs mostly get sick and lose weight after being infected, whereas newborn piglets usually die within five days of contracting the virus. PEDV cannot be transmitted to humans, nor contaminate the human food supply.
470:
Jang J, Yoon SH, Lee W, Yu J, Yoon J, Shim S, Kim H (2018) Time-calibrated phylogenomics of the porcine epidemic diarrhea virus: genome-wide insights into the spatio-temporal dynamics. Genes
Genomics 40(8):825-834. doi:
1275:
334:
Snelson, H. (2014). Comprehensive
Discussion of PEDv, Slide 3, American Association of Swine Veterinarians presentation to the 2014 Pork Management Conference, June 19, 2014,
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Dr. Rodger Main, Iowa State
University, Veterinary Diagnostic Lab, from the 2014 Iowa Pork Congress, January 22–23, Des Moines, IA, USA.
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Dr. Darin Madson, Iowa State
University, Veterinary Diagnostic Lab, from the 2013 Swine Health Seminar, August 16–18, 2013
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fomites. A study showed that when aerosolized virus particles can spread up to 10 miles from the source of infection.
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398:"Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines"
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Porcine
Epidemic Diarrhea Virus Emergence in the US: Status Report, Diagnostics, & Observations
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PEDV has a substantial economic burden given that it is highly infectious, resulting in significant
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Dr. Harry
Snelson, American Association of Swine Veterinarians, PEDV - Lessons Learned
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http://www.slideshare.net/trufflemedia/dr-harry-snelson-pedv-lessons-learned
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Dr. Liz
Wagstrom, U.S. National Pork Producers Council, PEDV - Next Steps
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30:
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349:"New Variant of Porcine Epidemic Diarrhea Virus, United States, 2014"
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221:
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Dr. Lisa Becton, U.S. National Pork Board, PEDV - Research Update
248:. It has also spread to North America: it was discovered in the
225:
1855:
1788:
1701:
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564:
447:"Deadly pig disease trims supplies, drives pork prices higher"
202:
514:
New
Variants of Porcine Epidemic Diarrhea Virus, China, 2011
273:
disease in the form of higher prices for pork products.
201:
that infects the cells lining the small intestine of a
1276:
Middle East respiratory syndrome-related coronavirus
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Rhinolophus ferrumequinum alphacoronavirus HuB-2013
701:
673:
662:
38:Porcine epidemic diarrhea virus particles seen by
1013:NL63-related bat coronavirus strain BtKYNL63-9b
556:What’s at stake for Canada as pig virus spreads
487:Transboundary and Emerging Diseases of Animals
576:
224:, but has become increasingly problematic in
8:
904:Nyctalus velutinus alphacoronavirus SC-2013
538:Porcine Epidemic Diarrhea Virus Status List
516:, from the U.S. Centers for Disease Control
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29:
18:
875:Myotis ricketti alphacoronavirus Sax-2011
421:
372:
347:Wang, L.; Byrum, B.; Zhang, Y. (2014).
327:
550:Porcine Epidemic Diarrhea Virus Update
299:mother's belly because they are cold
7:
911:Pipistrellus kuhlii coronavirus 3398
481:
479:
477:
1240:Bat Hp-betacoronavirus Zhejiang2013
1118:Transmissible gastroenteritis virus
540:, from the U.S. National Pork Board
534:, from June 4, 2014 World Pork Expo
528:, from June 4, 2014 World Pork Expo
522:, from June 4, 2014 World Pork Expo
290:the extant strains evolved ~1943.
285:Geographic spread of PEDV by year.
14:
1302:Tylonycteris bat coronavirus HKU4
1295:Pipistrellus bat coronavirus HKU5
1770:
1627:Common moorhen coronavirus HKU21
1339:Rousettus bat coronavirus GCCDC1
977:Rhinolophus bat coronavirus HKU2
846:Miniopterus bat coronavirus HKU8
50:
1829:Porcine epidemic diarrhea virus
1799:Porcine epidemic diarrhea virus
948:Scotophilus bat coronavirus 512
941:Porcine epidemic diarrhea virus
489:. Iowa State University. 2016.
186:Porcine epidemic diarrhea virus
175:Porcine epidemic diarrhea virus
23:Porcine epidemic diarrhea virus
1404:Bat SARS-like coronavirus WIV1
1346:Rousettus bat coronavirus HKU9
1183:China Rattus coronavirus HKU24
1070:Suncus murinus coronavirus X74
445:Enoch, D. (29 December 2013).
1:
1677:Night heron coronavirus HKU19
1042:Sorex araneus coronavirus T14
839:Miniopterus bat coronavirus 1
1503:Beluga whale coronavirus SW1
1332:Eidolon bat coronavirus C704
1113:Canine coronavirus HuPn-2018
353:Emerging Infectious Diseases
1648:White-eye coronavirus HKU16
396:Song, D.; Park, B. (2012).
220:It was first discovered in
1939:
782:Lucheng Rn rat coronavirus
207:porcine epidemic diarrhoea
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471:10.1007/s13258-018-0686-0
414:10.1007/s11262-012-0713-1
45:
37:
28:
21:
1620:Bulbul coronavirus HKU11
1591:Wigeon coronavirus HKU20
1376:SARS-related coronavirus
1211:Myodes coronavirus 2JL14
209:, a condition of severe
1641:Munia coronavirus HKU13
689:Bat coronavirus CDPHE15
1540:Avian coronavirus 9203
1474:Goose coronavirus CB17
1282:London1_novel CoV/2012
1269:Hedgehog coronavirus 1
1190:Human coronavirus HKU1
1175:Human coronavirus OC43
1006:Human coronavirus NL63
754:Human coronavirus 229E
365:10.3201/eid2005.140195
286:
1739:Microhyla letovirus 1
1547:Duck coronavirus 2714
718:Bat coronavirus HKU10
284:
47:Virus classification
228:countries, such as
40:electron microscopy
1918:Alphacoronaviruses
1197:Murine coronavirus
1170:Bovine coronavirus
1108:Canine coronavirus
1103:Feline coronavirus
1098:Alphacoronavirus 1
810:Mink coronavirus 1
655:Orthocoronavirinae
287:
252:on May 5, 2013 in
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1164:Betacoronavirus 1
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1139:Betacoronavirus
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624:Pisoniviricetes
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886:
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869:
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864:
863:
858:
848:
847:
843:
841:
840:
836:
835:
832:
829:
827:
826:
825:Minunacovirus
821:
811:
808:
807:
804:
801:
799:
798:
793:
783:
780:
779:
776:
773:
771:
770:
765:
755:
752:
751:
748:
745:
743:
742:
741:Duvinacovirus
737:
727:
726:
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720:
719:
715:
714:
711:
708:
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690:
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641:Coronaviridae
638:
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632:
631:
626:
625:
620:
619:
614:
613:
612:Orthornavirae
608:
607:
600:
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594:Coronaviridae
586:
581:
579:
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567:
566:
563:
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496:9780984627059
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138:Coronaviridae
135:
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120:
119:
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115:
111:
108:
107:
104:
103:
99:
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90:Orthornavirae
87:
84:
83:
80:
79:
75:
72:
69:
68:
65:
62:
59:
58:
53:
48:
44:
41:
36:
32:
27:
24:
20:
1798:
1738:
1726:
1717:
1703:
1676:
1664:Herdecovirus
1662:
1646:
1639:
1632:
1625:
1618:
1606:Buldecovirus
1604:
1590:
1576:
1565:
1545:
1538:
1531:
1517:
1501:
1487:
1473:
1459:
1448:
1374:
1362:Sarbecovirus
1360:
1344:
1337:
1330:
1316:
1300:
1293:
1274:
1267:
1255:Merbecovirus
1253:
1239:
1225:
1209:
1195:
1188:
1181:
1162:
1148:
1137:
1097:
1083:
1069:
1055:
1041:
1027:
1011:
1004:
992:Setracovirus
990:
976:
964:Rhinacovirus
962:
946:
940:
939:
925:
909:
902:
890:Nyctacovirus
888:
874:
862:Myotacovirus
860:
844:
837:
823:
809:
795:
781:
769:Luchacovirus
767:
753:
739:
723:
716:
702:
688:
674:
663:
653:
640:
634:
628:
622:
618:Pisuviricota
616:
610:
604:
592:
486:
466:
454:. Retrieved
450:
440:
405:
401:
391:
359:(5): 917–9.
356:
352:
342:
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316:
307:
304:Transmission
297:
288:
263:
219:
194:
190:
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174:
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161:
149:
137:
125:
113:
102:Pisuviricota
101:
89:
77:
70:
60:(unranked):
22:
1823:Wikispecies
1776:Wikispecies
1727:Milecovirus
1705:Letovirinae
1578:Andecovirus
1489:Cegacovirus
1318:Nobecovirus
1227:Hibecovirus
1150:Embecovirus
1085:Tegacovirus
1057:Sunacovirus
1029:Soracovirus
927:Pedacovirus
797:Minacovirus
704:Decacovirus
676:Colacovirus
630:Nidovirales
402:Virus Genes
242:Philippines
215:dehydration
199:coronavirus
162:Pedacovirus
126:Nidovirales
1912:Categories
1519:Igacovirus
1429:SHC014-CoV
1387:SARS-CoV-2
1382:SARS-CoV-1
456:11 January
451:Agri-Pulse
322:References
205:, causing
157:Subgenus:
1814:Q16023751
606:Riboviria
318:tissue.
277:Evolution
270:mortality
266:morbidity
256:, and in
191:PED virus
169:Species:
85:Kingdom:
78:Riboviria
1869:11460568
1808:Wikidata
1765:Source:
1409:RacCS203
1399:BANAL-52
1392:Variants
432:22270324
383:24750580
246:Thailand
211:diarrhea
133:Family:
97:Phylum:
423:7089188
374:4012824
254:Indiana
197:) is a
145:Genus:
121:Order:
109:Class:
1856:741063
1424:RpYN06
1419:RmYN02
1414:RaTG13
493:
430:
420:
381:
371:
258:Canada
244:, and
240:, the
222:Europe
1895:28295
1882:68586
1864:IRMNG
1843:4LWM9
639:>
633:>
627:>
621:>
615:>
609:>
238:Japan
234:China
230:Korea
226:Asian
71:Realm
64:Virus
1890:NCBI
1767:ICTV
491:ISBN
458:2014
428:PMID
379:PMID
268:and
213:and
195:PEDV
1877:ISC
1851:EoL
1838:CoL
1769:––
418:PMC
410:doi
369:PMC
361:doi
203:pig
193:or
1914::
1892::
1879::
1866::
1853::
1840::
1825::
1810::
476:^
449:.
426:.
416:.
406:44
404:.
400:.
377:.
367:.
357:20
355:.
351:.
236:,
232:,
73::
584:e
577:t
570:v
499:.
460:.
434:.
412::
385:.
363::
189:(
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