31:
72:
616:
with both types of porins have been found. They exhibit similar transport functions but have a more limited variety of porins, compared to the distribution found in gram-negative bacteria. Gram-positive bacteria lack outer membranes, so these porin channels are instead bound to specific lipids within
588:
molecules of various sizes and charges across the membrane. For survival, certain required nutrients and substrates must be transported into the cells. Likewise, toxins and wastes must be transported out to avoid toxic accumulation. Additionally, porins can regulate permeability and prevent lysis by
424:
Several parameters have been used to describe the structure of a porin protein. They include the tilting angle (α), shear number (S), strand number (n), and barrel radius (R). The tilting angle refers to the angle relative to the membrane. The shear number (S) is the number of amino acid residues
639:
Archaea also contain ion channels that have originated from general porins. The channels are found in the cell envelope and help facilitate solute transfer. They have similar characteristics as bacterial and mitochondrial porins, indicating physiological overlaps over all three domains of life.
600:, the inner membrane is the major permeability barrier. The outer membrane is more permeable to hydrophilic substances, due to the presence of porins. Porins have threshold sizes of transportable molecules that depend on the type of bacteria and porin. Generally, only substances less than 600
592:
Two types of porins exist to transport different materials– general and selective. General porins have no substrate specificities, though some exhibit slight preferences for anions or cations. Selective porins are smaller than general porins, and have specificities for chemical species. These
636:, through which eukaryotic organelles arose from gram-negative bacteria. However, eukaryotic porins exhibit the same limited diversity as gram-positive porins, and also display a greater voltage-dependent role during metabolism.
671:
in the porin gene. The mutations may lead to a loss of porins, resulting in the antibiotics having a lower permeability or being completely excluded from transport. These changes have contributed to the global emergence of
405:
porin. Depending on the size of the porin, the interior of the protein may either be filled with water, have up to two β strands folded back into the interior, or contain a "stopper" segment composed of β strands.
425:
found in each β strands. Strand number (n) is the amount of β strands in the porin, and barrel radius (R) refers to the radius of the opening of the porin. These parameters are related via the following formulas:
374:(β barrel). The amino acid composition of the porin β strands are unique in that polar and nonpolar residues alternate along them. This means that the nonpolar residues face outward so as to interact with the
392:
The β barrels that make up a porin are composed of as few as eight β strands to as many as twenty-two β strands. The individual strands are joined together by loops and turns. The majority of porins are
487:
548:
2350:
3260:
553:
Using these formulas, the structure of a porin can be determined by knowing only a few of the available parameters. While the structure of many porins have been determined using
712:β-strands (β-TMS). These include the GBP, SP and RPP porin families. While PSF I includes 47 families, PSF II-V each contain only 2 families. While PSF I derives members from
2995:
2247:
2180:
569:
Porins are water-filled pores and channels found in the membranes of bacteria and eukaryotes. Porin-like channels have also been discovered in archaea. Note that the term "
241:
185:
173:
1374:
Benz R (1989). "Porins from
Mitochondrial and Bacterial Outer Membranes: Structural and Functional Aspects". In Azzi A, Nałęz KA, Nałęcz MJ, Wojtczak L (eds.).
772:
810:
3191:
3174:
3169:
3164:
3159:
1332:
Yen MR, Peabody CR, Partovi SM, Zhai Y, Tseng YH, Saier MH (May 2002). "Protein-translocating outer membrane porins of Gram-negative bacteria".
632:. The organelles contain general porins that are structurally and functionally similar to bacterial ones. These similarities have supported the
3196:
2294:
1566:
1391:
1215:
141:
3248:
2429:
413:
in the outer membrane, meaning that three identical porin subunits associate together to form a porin super-structure with three channels.
3146:
2167:
1583:
951:
This superfamily includes protein that comprise pores in multicomponent protein translocases as follows: 3.A.8 - ; 1.B.69 - ; 3.D.9 -
2932:
959:
857:
3802:
1288:
Novikova OD, Solovyeva TF (2009). "Nonspecific Porins of the Outer
Membrane of Gram-Negative Bacteria: Structure and Functions".
3797:
3525:
2524:
2302:
1618:
979:
862:
767:
3547:
805:
756:
729:
261:
3756:
1667:
431:
3122:
2034:
3397:
421:
between each monomer in the homotrimer ensure that they do not dissociate, and remain together in the outer membrane.
367:
498:
1575:
1559:
296:
3751:
1961:
777:
558:
197:
389:
channel. The specific amino acids in the channel determine the specificity of the porin to different molecules.
3741:
2002:
1878:
1006:
819:
382:
308:
1095:
Faller M, Niederweis M, Schulz GE (February 2004). "The structure of a mycobacterial outer-membrane channel".
743:
249:
3746:
1507:"NMR localization of the O-mycoloylation on PorH, a channel forming peptide from Corynebacterium glutamicum"
852:
796:
593:
specificities are determined by the threshold sizes of the porins, and the amino acid residues lining them.
45:
790:
664:. Specific antibiotics have been designed to travel through porins in order to inhibit cellular processes.
3777:
1769:
1756:
1743:
1723:
1710:
1675:
891:
833:
784:
713:
613:
597:
316:
312:
970:
1.B.34 - The
Corynebacterial Porin A (PorA) Family 1.B.59 - The Outer Membrane Porin, PorH (PorH) Family
1552:
709:
673:
554:
245:
1157:
Galdiero S, Falanga A, Cantisani M, Tarallo R, Della Pepa ME, D'Oriano V, Galdiero M (December 2012).
1650:
1104:
841:
633:
418:
331:
154:
202:
1544:
929:
828:
705:
359:
40:
3117:
1993:
1640:
1487:
1305:
1128:
653:
2155:
1528:
1479:
1438:
1387:
1349:
1261:
1211:
1188:
1120:
1077:
1036:
716:
primarily one family of eukaryotic mitochondrial porins, PSF II and V porins are derived from
692:
The discovery of porins has been attributed to
Hiroshi Nikaido, nicknamed "the porinologist."
300:
236:
50:
30:
2924:
1905:
1518:
1469:
1428:
1420:
1379:
1341:
1297:
1251:
1178:
1170:
1112:
1067:
1028:
578:
385:, whereas the polar residues face inwards into the center of the beta barrel to create the
228:
1600:
661:
708:
of porins. Porin superfamily I includes 47 families of porins with a range of numbers of
1108:
3256:
1943:
1433:
1408:
1183:
1158:
717:
677:
1345:
178:
3791:
3210:
2883:
1474:
1457:
1424:
601:
414:
398:
327:
323:
319:
284:
146:
1491:
1309:
1132:
97:
3563:
2954:
629:
625:
574:
224:
1523:
1506:
1206:
Schulz GE (2004). "Chapter 2: The
Structures of General Porins". In Benz R (ed.).
1002:
656:
that lead to bacterial degradation. Therapeutic treatments, like vaccinations and
190:
110:
1383:
1159:"Microbe-host interactions: structure and role of Gram-negative bacterial porins"
1072:
1055:
1019:
Schirmer T (1998). "General and specific porins from bacterial outer membranes".
166:
122:
3493:
3488:
3483:
3478:
3365:
3204:
1579:
649:
585:
570:
371:
347:
304:
277:
1174:
3473:
2839:
2207:
2175:
1301:
1240:"Voltage-dependent porin-like ion channels in the archaeon Haloferax volcanii"
736:
657:
410:
363:
343:
3558:
3468:
1116:
984:
681:
667:
However, due to selective pressure, bacteria can develop resistance through
624:
Porins are also found in eukaryotes, specifically in the outer membranes of
618:
355:
351:
292:
288:
1532:
1483:
1442:
1353:
1192:
1124:
1081:
1032:
866:
1.B.42 - The Outer
Membrane Lipopolysaccharide Export Porin (LPS-EP) Family
307:
that are specific to different types of molecules. They are present in the
1265:
1256:
1239:
1040:
920:
1.B.78 - The DUF3374 Electron
Transport-associated Porin (ETPorin) Family
849:
1.B.33 Outer membrane protein insertion porin (Bam complex) (OmpIP) family
150:
3571:
2919:
1898:
1893:
1888:
1883:
1815:
1810:
1505:
Rath P, Saurel O, Tropis M, Daffé M, Demange P, Milon A (November 2013).
668:
402:
375:
280:
117:
3698:
3455:
3291:
1792:
1787:
1782:
933:
1.B.58 - Nocardial Hetero-oligomeric Cell Wall
Channel (NfpA/B) Family
887:
394:
386:
134:
129:
35:
1458:"Mycobacterial porins--new channel proteins in unique outer membranes"
54:
17:
3375:
3370:
3104:
3099:
3045:
3040:
2856:
2844:
2834:
2829:
2817:
2812:
2807:
2694:
2689:
2684:
2576:
2512:
2507:
2502:
2497:
2492:
2487:
2482:
2417:
2412:
2402:
2397:
2392:
2343:
2338:
2328:
2323:
2200:
2195:
2190:
2185:
2091:
2086:
2081:
2071:
2066:
2056:
2051:
1981:
1976:
1971:
1966:
1869:
1864:
1859:
1854:
1842:
1837:
1832:
1827:
1736:
1703:
1698:
1693:
1688:
778:
Nucleoside-specific channel-forming outer membrane porin (Tsx) family
256:
898:
1.B.57 - The
Legionella Major-Outer Membrane Protein (LM-OMP) Family
71:
943:
1.B.47 - The
Plastid Outer Envelope Porin of 37 kDa (OEP37) Family
3609:
3540:
3535:
3530:
3447:
3434:
3429:
3424:
3419:
3414:
3409:
3360:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3306:
3301:
3296:
3286:
3281:
3276:
3271:
3186:
3130:
3087:
3082:
3077:
3072:
3067:
3062:
3057:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
2986:
2981:
2976:
2971:
2959:
2876:
2871:
2866:
2851:
2789:
2784:
2779:
2770:
2765:
2751:
2746:
2737:
2732:
2727:
2718:
2713:
2704:
2699:
2666:
2661:
2656:
2651:
2642:
2633:
2628:
2623:
2614:
2609:
2604:
2599:
2590:
2585:
2571:
2566:
2561:
2556:
2551:
2546:
2541:
2477:
2472:
2467:
2462:
2457:
2452:
2447:
2442:
2407:
2377:
2372:
2367:
2362:
2333:
2282:
2277:
2272:
2267:
2257:
2252:
2232:
2217:
2212:
2127:
2122:
2117:
2112:
2096:
2076:
2061:
2022:
2017:
2012:
2007:
1915:
1910:
1633:
1628:
1623:
954:
1.B.30 - The Plastid Outer Envelope Porin of 16 kDa (OEP16) Family
941:
1.B.28 - The Plastid Outer Envelope Porin of 24 kDa (OEP24) Family
378:
29:
916:
1.B.72 - The Protochlamydial Outer Membrane Porin (PomS/T) Family
573:" refers to unrelated proteins that facilitate transport through
3689:
3684:
3679:
3669:
3664:
3659:
3649:
3644:
3639:
3634:
3629:
3624:
3619:
3604:
3599:
3594:
3589:
3584:
3579:
3518:
3513:
3508:
3503:
3498:
3404:
3392:
3387:
3382:
3313:
3266:
3230:
3225:
3220:
3215:
2942:
2760:
2318:
1655:
1645:
914:
1.B.71 - The Proteobacterial/Verrucomicrobial Porin (PVP) Family
701:
218:
161:
104:
92:
3719:
2904:
2150:
1938:
1595:
1548:
1208:
Bacterial and eukaryotic porins: structure, function, mechanism
3243:
3141:
2262:
2222:
902:
1.B.61 - The Delta-Proteobacterial Porin (Delta-Porin) Family
910:
1.B.68 - The Putative Beta Barrel Porin-5 (BBP5) Superfamily
612:
Porins were first discovered in gram-negative bacteria, but
966:
Porin Superfamily V (Corynebacterial PorA/PorH Superfamily)
947:
Porin Superfamily IV (Tim17/OEP16/PxMPL (TOP) Superfamily)
823:
1.B.22 Outer bacterial membrane secretin (secretin) family
956:
1.B.69 - The Peroxysomal Membrane Porin 4 (PxMP4) Family
896:
1.B.55 - The Poly Acetyl Glucosamine Porin (PgaA) Family
584:
Porins are primarily involved in passively transporting
1056:"Folding and assembly of beta-barrel membrane proteins"
908:
1.B.67 - The Putative Beta Barrel Porin-4 (BBP4) Family
906:
1.B.66 - The Putative Beta-Barrel Porin-2 (BBP2) Family
847:
1.B.32 Fusobacterial outer membrane porin (FomP) family
781:
1.B.11 Outer membrane fimbrial usher porin (FUP) family
720:. PSF III and V are derived from eukaryotic organelle.
918:
1.B.73 - The Capsule Biogenesis/Assembly (CBA) Family
501:
434:
802:
1.B.16 Short chain amide and urea porin (SAP) family
3732:
3556:
3445:
3241:
3139:
3115:
2917:
2523:
2428:
2293:
2166:
2033:
1992:
1954:
1666:
1611:
482:{\displaystyle 2\pi R={\frac {nb}{2\cos(\alpha )}}}
255:
235:
217:
212:
196:
184:
172:
160:
140:
128:
116:
103:
91:
83:
78:
64:
1378:. Berlin, Heidelberg: Springer. pp. 199–214.
1334:Biochimica et Biophysica Acta (BBA) - Biomembranes
1060:Biochimica et Biophysica Acta (BBA) - Biomembranes
904:1.B.62 - The Putative Bacterial Porin (PBP) Family
542:
481:
814:1.B.19 Glucose-selective OprB porin (OprB) family
912:1.B.70 - The Outer Membrane Channel (OMC) Family
589:limiting the entry of detergents into the cell.
1283:
1281:
1279:
1277:
1275:
1238:Besnard M, Martinac B, Ghazi A (January 1997).
858:Oligogalacturonate-specific porin (KdgM) family
1233:
1231:
1229:
1227:
1152:
1150:
1148:
1146:
1144:
1142:
543:{\displaystyle \tan(\alpha )={\frac {Sa}{nb}}}
1560:
900:1.B.60 - The Omp50 Porin (Omp50 Porin) Family
811:Outer membrane auxiliary (OMA) protein family
8:
1369:
1367:
1365:
1363:
874:1.B.44 - The Probable Protein Translocating
768:Mitochondrial and plastid porin (MPP) family
704:, there are five evolutionarily independent
401:porins have been discovered, as well as an
3729:
3716:
2914:
2901:
2163:
2147:
1951:
1935:
1608:
1592:
1567:
1553:
1545:
1327:
1325:
1323:
1321:
1319:
1054:Tamm LK, Hong H, Liang B (November 2004).
209:
1522:
1473:
1432:
1376:Anion Carriers of Mitochondrial Membranes
1255:
1182:
1071:
1005:at the U.S. National Library of Medicine
816:1.B.20 Two-partner secretion (TPS) family
773:FadL outer membrane protein (FadL) family
520:
500:
447:
433:
350:(β strands) which are linked together by
845:major outer membrane porin (MomP) family
825:1.B.23 Cyanobacterial porin (CBP) family
733:1.B.2 - The Chlamydial Porin (CP) Family
1210:. Weinheim: Wiley-VCH. pp. 26–29.
995:
924:Porin Superfamily II (MspA Superfamily)
557:, the alternative method of sequencing
837:1.B.26 Cyclodextrin porin (CDP) family
370:and form a cylindrical tube, called a
366:on the other. The β strands lie in an
61:
1163:Current Protein & Peptide Science
7:
800:1.B.15 Raffinose porin (RafY) family
797:Outer membrane receptor (OMR) family
2933:Calcium-activated chloride channels
1244:The Journal of Biological Chemistry
863:Bacterial porin, OmpW (OmpW) family
299:, porins are large enough to allow
2003:Amiloride-sensitive cation channel
806:Outer membrane factor (OMF) family
25:
960:Mitochondrial Protein Translocase
834:Outer membrane porin (Opr) family
648:Many porins are targets for host
287:and act as a pore, through which
1475:10.1046/j.1365-2958.2003.03662.x
1425:10.1128/JB.187.24.8232-8236.2005
70:
3526:Voltage-dependent anion channel
1619:Inositol trisphosphate receptor
1456:Niederweis M (September 2003).
980:Voltage-dependent anion channel
3548:General bacterial porin family
730:General bacterial porin family
660:, are used to supplement this
514:
508:
473:
467:
1:
1524:10.1016/j.febslet.2013.09.032
1346:10.1016/s0005-2736(02)00359-0
1021:Journal of Structural Biology
604:in size can diffuse through.
213:Available protein structures:
1384:10.1007/978-3-642-74539-3_16
1073:10.1016/j.bbamem.2004.06.011
757:OmpA-OmpF porin (OOP) family
1407:Klebba PE (December 2005).
297:membrane transport proteins
27:Group of transport proteins
3819:
2967:Chloride Channel Accessory
1576:Membrane transport protein
1175:10.2174/138920312804871120
561:may also be used instead.
419:dipole-dipole interactions
334:(outer plastid membrane).
332:outer chloroplast membrane
3773:
3728:
3715:
2913:
2900:
2162:
2146:
1962:Epithelial sodium channel
1950:
1934:
1607:
1591:
1302:10.1134/S1990747809010024
559:protein primary structure
326:), the outer membrane of
322:(mycolic acid-containing
208:
69:
1879:Cation channels of sperm
1007:Medical Subject Headings
884:P44 (A-P44) Porin Family
876:Porphyromonas gingivalis
820:OmpG porin (OmpG) family
764:PorCa porin (RPP) family
744:Brucella-Rhizobium porin
3803:Outer membrane proteins
1413:Journal of Bacteriology
1290:Biologicheskie Membrany
1117:10.1126/science.1094114
753:OprP Porin (POP) Family
342:Porins are composed of
46:gram-negative bacterium
3798:Transmembrane proteins
1462:Molecular Microbiology
1033:10.1006/jsbi.1997.3946
890:/Invasin (Int/Inv) or
872:Porin P1 (CPP1) Family
853:Corynebacterial porins
714:gram-negative bacteria
614:gram-positive bacteria
598:gram-negative bacteria
544:
483:
346:(β sheets) made up of
313:gram-negative bacteria
59:
41:Salmonella typhimurium
1955:Constitutively active
1257:10.1074/jbc.272.2.992
937:Porin Superfamily III
791:Alginate export porin
676:, and an increase in
674:antibiotic resistance
644:Antibiotic resistance
555:X-ray crystallography
545:
484:
33:
842:Campylobacter jejuni
634:Endosymbiotic theory
499:
432:
368:antiparallel fashion
303:, i.e., they act as
38:specific porin from
3722:By gating mechanism
1109:2004Sci...303.1189F
930:Mycobacterial porin
878:Porin (PorT) Family
829:Mycobacterial porin
724:Porin Superfamily I
65:Gram-negative porin
3249:TRP cation channel
3147:CNG cation channel
2430:Tandem pore domain
1641:Ryanodine receptor
1409:"The porinologist"
654:signaling pathways
540:
479:
60:
3785:
3784:
3769:
3768:
3765:
3764:
3757:Stretch-activated
3734:Ion channel class
3711:
3710:
3707:
3706:
2896:
2895:
2892:
2891:
2168:Calcium-activated
2156:Potassium channel
2142:
2141:
2138:
2137:
1930:
1929:
1926:
1925:
1393:978-3-642-74541-6
1217:978-3-527-30775-3
1103:(5661): 1189–92.
892:Autotransporter-3
785:Autotransporter-1
538:
477:
354:(β turns) on the
301:passive diffusion
285:cellular membrane
271:
270:
267:
266:
262:structure summary
87:Porin_08134891516
16:(Redirected from
3810:
3730:
3717:
2925:Chloride channel
2915:
2902:
2295:Inward-rectifier
2164:
2148:
1952:
1936:
1906:Two-pore channel
1609:
1593:
1569:
1562:
1555:
1546:
1537:
1536:
1526:
1502:
1496:
1495:
1477:
1453:
1447:
1446:
1436:
1404:
1398:
1397:
1371:
1358:
1357:
1329:
1314:
1313:
1285:
1270:
1269:
1259:
1235:
1222:
1221:
1203:
1197:
1196:
1186:
1154:
1137:
1136:
1092:
1086:
1085:
1075:
1051:
1045:
1044:
1016:
1010:
1000:
579:nuclear envelope
549:
547:
546:
541:
539:
537:
529:
521:
488:
486:
485:
480:
478:
476:
456:
448:
415:Hydrogen bonding
409:All porins form
397:; however, some
210:
74:
62:
57:
21:
3818:
3817:
3813:
3812:
3811:
3809:
3808:
3807:
3788:
3787:
3786:
3781:
3761:
3724:
3703:
3552:
3451:
3441:
3237:
3135:
3111:
2909:
2888:
2802:
2679:
2536:
2519:
2424:
2388:
2358:
2314:
2306:
2289:
2243:
2158:
2134:
2107:
2046:
2029:
1988:
1946:
1922:
1805:
1777:
1764:
1751:
1731:
1718:
1683:
1662:
1603:
1601:Calcium channel
1587:
1573:
1542:
1540:
1517:(22): 3687–91.
1504:
1503:
1499:
1455:
1454:
1450:
1406:
1405:
1401:
1394:
1373:
1372:
1361:
1331:
1330:
1317:
1287:
1286:
1273:
1237:
1236:
1225:
1218:
1205:
1204:
1200:
1156:
1155:
1140:
1094:
1093:
1089:
1066:(1–2): 250–63.
1053:
1052:
1048:
1018:
1017:
1013:
1001:
997:
993:
976:
968:
957:
955:
949:
942:
939:
932:
926:
919:
917:
915:
913:
911:
909:
907:
905:
903:
901:
899:
897:
895:
885:
879:
873:
867:
865:
860:
855:
850:
848:
846:
838:
836:
831:
826:
824:
822:
817:
815:
813:
808:
803:
801:
799:
794:
788:
782:
780:
775:
770:
765:
759:
754:
748:
740:
734:
732:
726:
698:
690:
678:mortality rates
662:immune response
652:, resulting in
646:
610:
567:
530:
522:
497:
496:
457:
449:
430:
429:
340:
295:. Unlike other
174:OPM superfamily
49:
28:
23:
22:
15:
12:
11:
5:
3816:
3814:
3806:
3805:
3800:
3790:
3789:
3783:
3782:
3774:
3771:
3770:
3767:
3766:
3763:
3762:
3760:
3759:
3754:
3749:
3744:
3738:
3736:
3726:
3725:
3720:
3713:
3712:
3709:
3708:
3705:
3704:
3702:
3701:
3696:
3695:
3694:
3693:
3692:
3687:
3682:
3674:
3673:
3672:
3667:
3662:
3654:
3653:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3614:
3613:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3568:
3566:
3554:
3553:
3551:
3550:
3545:
3544:
3543:
3538:
3533:
3523:
3522:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3465:
3463:
3449:
3443:
3442:
3440:
3439:
3438:
3437:
3432:
3427:
3422:
3417:
3412:
3402:
3401:
3400:
3395:
3385:
3380:
3379:
3378:
3373:
3368:
3358:
3357:
3356:
3351:
3346:
3341:
3336:
3331:
3326:
3321:
3311:
3310:
3309:
3304:
3299:
3294:
3289:
3284:
3279:
3274:
3264:
3253:
3251:
3239:
3238:
3236:
3235:
3234:
3233:
3228:
3223:
3218:
3213:
3201:
3200:
3199:
3194:
3189:
3179:
3178:
3177:
3172:
3167:
3162:
3151:
3149:
3137:
3136:
3134:
3133:
3127:
3125:
3123:Proton channel
3113:
3112:
3110:
3109:
3108:
3107:
3102:
3092:
3091:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3050:
3049:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
2998:
2993:
2992:
2991:
2990:
2989:
2984:
2979:
2974:
2964:
2963:
2962:
2957:
2947:
2946:
2945:
2929:
2927:
2911:
2910:
2905:
2898:
2897:
2894:
2893:
2890:
2889:
2887:
2886:
2881:
2880:
2879:
2874:
2869:
2859:
2854:
2849:
2848:
2847:
2842:
2837:
2832:
2822:
2821:
2820:
2815:
2810:
2800:
2795:
2794:
2793:
2792:
2787:
2782:
2775:
2774:
2773:
2768:
2763:
2756:
2755:
2754:
2749:
2742:
2741:
2740:
2735:
2730:
2723:
2722:
2721:
2716:
2709:
2708:
2707:
2702:
2697:
2692:
2687:
2677:
2672:
2671:
2670:
2669:
2664:
2659:
2654:
2647:
2646:
2645:
2638:
2637:
2636:
2631:
2626:
2619:
2618:
2617:
2612:
2607:
2602:
2595:
2594:
2593:
2588:
2581:
2580:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2534:
2529:
2527:
2521:
2520:
2518:
2517:
2516:
2515:
2510:
2505:
2500:
2495:
2490:
2485:
2480:
2475:
2470:
2465:
2460:
2455:
2450:
2445:
2434:
2432:
2426:
2425:
2423:
2422:
2421:
2420:
2415:
2410:
2405:
2400:
2395:
2386:
2382:
2381:
2380:
2375:
2370:
2365:
2356:
2348:
2347:
2346:
2341:
2336:
2331:
2326:
2321:
2312:
2308:
2304:
2299:
2297:
2291:
2290:
2288:
2287:
2286:
2285:
2280:
2275:
2270:
2265:
2260:
2255:
2250:
2241:
2237:
2236:
2235:
2227:
2226:
2225:
2220:
2215:
2205:
2204:
2203:
2198:
2193:
2188:
2183:
2172:
2170:
2160:
2159:
2151:
2144:
2143:
2140:
2139:
2136:
2135:
2133:
2132:
2131:
2130:
2125:
2120:
2115:
2105:
2101:
2100:
2099:
2094:
2089:
2084:
2079:
2074:
2069:
2064:
2059:
2054:
2044:
2039:
2037:
2031:
2030:
2028:
2027:
2026:
2025:
2020:
2015:
2010:
1999:
1997:
1990:
1989:
1987:
1986:
1985:
1984:
1979:
1974:
1969:
1958:
1956:
1948:
1947:
1944:Sodium channel
1939:
1932:
1931:
1928:
1927:
1924:
1923:
1921:
1920:
1919:
1918:
1913:
1903:
1902:
1901:
1896:
1891:
1886:
1875:
1874:
1873:
1872:
1867:
1862:
1857:
1847:
1846:
1845:
1840:
1835:
1830:
1820:
1819:
1818:
1813:
1803:
1798:
1797:
1796:
1795:
1790:
1785:
1775:
1767:
1762:
1754:
1749:
1741:
1740:
1739:
1729:
1721:
1716:
1708:
1707:
1706:
1701:
1696:
1691:
1681:
1672:
1670:
1664:
1663:
1661:
1660:
1659:
1658:
1653:
1648:
1638:
1637:
1636:
1631:
1626:
1615:
1613:
1605:
1604:
1596:
1589:
1588:
1574:
1572:
1571:
1564:
1557:
1549:
1539:
1538:
1497:
1468:(5): 1167–77.
1448:
1419:(24): 8232–6.
1399:
1392:
1359:
1315:
1271:
1223:
1216:
1198:
1138:
1087:
1046:
1011:
994:
992:
989:
988:
987:
982:
975:
972:
967:
964:
948:
945:
938:
935:
925:
922:
725:
722:
718:Actinomycetota
710:trans-membrane
697:
696:Classification
694:
689:
686:
645:
642:
609:
606:
566:
565:Cellular roles
563:
551:
550:
536:
533:
528:
525:
519:
516:
513:
510:
507:
504:
490:
489:
475:
472:
469:
466:
463:
460:
455:
452:
446:
443:
440:
437:
383:outer membrane
358:side and long
339:
336:
309:outer membrane
269:
268:
265:
264:
259:
253:
252:
239:
233:
232:
222:
215:
214:
206:
205:
200:
194:
193:
188:
182:
181:
176:
170:
169:
164:
158:
157:
144:
138:
137:
132:
126:
125:
120:
114:
113:
108:
101:
100:
95:
89:
88:
85:
81:
80:
76:
75:
67:
66:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3815:
3804:
3801:
3799:
3796:
3795:
3793:
3780:
3779:
3772:
3758:
3755:
3753:
3752:Voltage-gated
3750:
3748:
3745:
3743:
3740:
3739:
3737:
3735:
3731:
3727:
3723:
3718:
3714:
3700:
3697:
3691:
3688:
3686:
3683:
3681:
3678:
3677:
3675:
3671:
3668:
3666:
3663:
3661:
3658:
3657:
3655:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3617:
3615:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3577:
3575:
3574:
3573:
3570:
3569:
3567:
3565:
3562:
3560:
3555:
3549:
3546:
3542:
3539:
3537:
3534:
3532:
3529:
3528:
3527:
3524:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3471:
3470:
3467:
3466:
3464:
3462:
3459:
3457:
3453:
3444:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3407:
3406:
3403:
3399:
3396:
3394:
3391:
3390:
3389:
3386:
3384:
3381:
3377:
3374:
3372:
3369:
3367:
3364:
3363:
3362:
3359:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3316:
3315:
3312:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3273:
3270:
3269:
3268:
3265:
3262:
3258:
3255:
3254:
3252:
3250:
3247:
3245:
3240:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3208:
3207:
3206:
3202:
3198:
3195:
3193:
3190:
3188:
3185:
3184:
3183:
3180:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3157:
3156:
3153:
3152:
3150:
3148:
3145:
3143:
3138:
3132:
3129:
3128:
3126:
3124:
3121:
3119:
3114:
3106:
3103:
3101:
3098:
3097:
3096:
3093:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3055:
3054:
3051:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3003:
3002:
2999:
2997:
2994:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2969:
2968:
2965:
2961:
2958:
2956:
2953:
2952:
2951:
2948:
2944:
2941:
2940:
2939:
2936:
2935:
2934:
2931:
2930:
2928:
2926:
2923:
2921:
2916:
2912:
2908:
2907:Miscellaneous
2903:
2899:
2885:
2884:Shaker (gene)
2882:
2878:
2875:
2873:
2870:
2868:
2865:
2864:
2863:
2860:
2858:
2857:minK/ISK-like
2855:
2853:
2850:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2827:
2826:
2823:
2819:
2816:
2814:
2811:
2809:
2806:
2805:
2804:
2797:
2796:
2791:
2788:
2786:
2783:
2781:
2778:
2777:
2776:
2772:
2769:
2767:
2764:
2762:
2759:
2758:
2757:
2753:
2750:
2748:
2745:
2744:
2743:
2739:
2736:
2734:
2731:
2729:
2726:
2725:
2724:
2720:
2717:
2715:
2712:
2711:
2710:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2682:
2681:
2674:
2673:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2649:
2648:
2644:
2641:
2640:
2639:
2635:
2632:
2630:
2627:
2625:
2622:
2621:
2620:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2597:
2596:
2592:
2589:
2587:
2584:
2583:
2582:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2539:
2538:
2531:
2530:
2528:
2526:
2525:Voltage-gated
2522:
2514:
2511:
2509:
2506:
2504:
2501:
2499:
2496:
2494:
2491:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2464:
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2444:
2441:
2440:
2439:
2436:
2435:
2433:
2431:
2427:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2394:
2391:
2390:
2389:
2383:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2360:
2359:
2352:
2349:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2316:
2315:
2309:
2307:
2301:
2300:
2298:
2296:
2292:
2284:
2281:
2279:
2276:
2274:
2271:
2269:
2266:
2264:
2261:
2259:
2256:
2254:
2251:
2249:
2246:
2245:
2244:
2238:
2234:
2231:
2230:
2228:
2224:
2221:
2219:
2216:
2214:
2211:
2210:
2209:
2206:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2178:
2177:
2174:
2173:
2171:
2169:
2165:
2161:
2157:
2154:
2149:
2145:
2129:
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2110:
2109:
2102:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2049:
2048:
2041:
2040:
2038:
2036:
2035:Voltage-gated
2032:
2024:
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2005:
2004:
2001:
2000:
1998:
1995:
1991:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1964:
1963:
1960:
1959:
1957:
1953:
1949:
1945:
1942:
1937:
1933:
1917:
1914:
1912:
1909:
1908:
1907:
1904:
1900:
1897:
1895:
1892:
1890:
1887:
1885:
1882:
1881:
1880:
1877:
1876:
1871:
1868:
1866:
1863:
1861:
1858:
1856:
1853:
1852:
1851:
1848:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1825:
1824:
1821:
1817:
1814:
1812:
1809:
1808:
1807:
1800:
1799:
1794:
1791:
1789:
1786:
1784:
1781:
1780:
1779:
1771:
1768:
1766:
1758:
1755:
1753:
1745:
1742:
1738:
1735:
1734:
1733:
1725:
1722:
1720:
1712:
1709:
1705:
1702:
1700:
1697:
1695:
1692:
1690:
1687:
1686:
1685:
1677:
1674:
1673:
1671:
1669:
1668:Voltage-gated
1665:
1657:
1654:
1652:
1649:
1647:
1644:
1643:
1642:
1639:
1635:
1632:
1630:
1627:
1625:
1622:
1621:
1620:
1617:
1616:
1614:
1610:
1606:
1602:
1599:
1594:
1590:
1585:
1581:
1577:
1570:
1565:
1563:
1558:
1556:
1551:
1550:
1547:
1543:
1534:
1530:
1525:
1520:
1516:
1512:
1508:
1501:
1498:
1493:
1489:
1485:
1481:
1476:
1471:
1467:
1463:
1459:
1452:
1449:
1444:
1440:
1435:
1430:
1426:
1422:
1418:
1414:
1410:
1403:
1400:
1395:
1389:
1385:
1381:
1377:
1370:
1368:
1366:
1364:
1360:
1355:
1351:
1347:
1343:
1340:(1–2): 6–31.
1339:
1335:
1328:
1326:
1324:
1322:
1320:
1316:
1311:
1307:
1303:
1299:
1295:
1291:
1284:
1282:
1280:
1278:
1276:
1272:
1267:
1263:
1258:
1253:
1249:
1245:
1241:
1234:
1232:
1230:
1228:
1224:
1219:
1213:
1209:
1202:
1199:
1194:
1190:
1185:
1180:
1176:
1172:
1169:(8): 843–54.
1168:
1164:
1160:
1153:
1151:
1149:
1147:
1145:
1143:
1139:
1134:
1130:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1091:
1088:
1083:
1079:
1074:
1069:
1065:
1061:
1057:
1050:
1047:
1042:
1038:
1034:
1030:
1026:
1022:
1015:
1012:
1008:
1004:
999:
996:
990:
986:
983:
981:
978:
977:
973:
971:
965:
963:
962:(MPT) Family
961:
952:
946:
944:
936:
934:
931:
923:
921:
893:
889:
883:
880:1.B.49 - The
877:
871:
868:1.B.43 - The
864:
859:
854:
844:
843:
835:
830:
821:
812:
807:
798:
792:
787:(AT-1) family
786:
779:
774:
769:
763:
758:
752:
746:
745:
738:
731:
723:
721:
719:
715:
711:
707:
706:superfamilies
703:
700:According to
695:
693:
687:
685:
683:
679:
675:
670:
665:
663:
659:
655:
651:
643:
641:
637:
635:
631:
627:
622:
620:
615:
607:
605:
603:
599:
594:
590:
587:
582:
580:
576:
575:nuclear pores
572:
564:
562:
560:
556:
534:
531:
526:
523:
517:
511:
505:
502:
495:
494:
493:
470:
464:
461:
458:
453:
450:
444:
441:
438:
435:
428:
427:
426:
422:
420:
416:
412:
407:
404:
400:
396:
390:
388:
384:
380:
377:
373:
369:
365:
361:
357:
353:
349:
345:
337:
335:
333:
329:
325:
324:actinomycetes
321:
318:
317:gram-positive
314:
310:
306:
302:
298:
294:
290:
286:
283:that cross a
282:
279:
275:
263:
260:
258:
254:
251:
247:
243:
240:
238:
234:
230:
226:
223:
220:
216:
211:
207:
204:
201:
199:
195:
192:
189:
187:
183:
180:
177:
175:
171:
168:
165:
163:
159:
156:
152:
148:
145:
143:
139:
136:
133:
131:
127:
124:
121:
119:
115:
112:
109:
106:
102:
99:
96:
94:
90:
86:
82:
77:
73:
68:
63:
56:
52:
47:
43:
42:
37:
32:
19:
3775:
3742:Ligand-gated
3733:
3721:
3564:Gap junction
3557:
3460:
3446:
3242:
3203:
3181:
3154:
3140:
3116:
3094:
3052:
3000:
2966:
2949:
2937:
2918:
2906:
2861:
2824:
2798:
2675:
2532:
2437:
2384:
2354:
2310:
2239:
2152:
2103:
2042:
1940:
1849:
1822:
1801:
1773:
1760:
1747:
1727:
1714:
1679:
1612:Ligand-gated
1597:
1580:ion channels
1541:
1514:
1511:FEBS Letters
1510:
1500:
1465:
1461:
1451:
1416:
1412:
1402:
1375:
1337:
1333:
1293:
1289:
1250:(2): 992–5.
1247:
1243:
1207:
1201:
1166:
1162:
1100:
1096:
1090:
1063:
1059:
1049:
1027:(2): 101–9.
1024:
1020:
1014:
998:
969:
958:3.A.8 - The
953:
950:
940:
927:
881:
875:
869:
840:
793:(AEP) family
761:
750:
749:1.B.5 - The
747:(BRP) Family
742:
741:1.B.4 - The
735:1.B.3 - The
728:1.B.1 - The
727:
699:
691:
666:
650:immune cells
647:
638:
630:chloroplasts
626:mitochondria
623:
611:
595:
591:
583:
568:
552:
491:
423:
408:
391:
348:beta strands
341:
328:mitochondria
320:mycobacteria
273:
272:
39:
3747:Light-gated
2229:IK channel
1296:(1): 3–15.
762:Rhodobacter
751:Pseudomonas
739:(SP) Family
737:Sugar porin
658:antibiotics
586:hydrophilic
571:nucleoporin
411:homotrimers
372:beta barrel
364:amino acids
356:cytoplasmic
344:beta sheets
278:beta barrel
186:OPM protein
79:Identifiers
3792:Categories
2950:Bestrophin
2208:SK channel
2176:BK channel
1850:γ-subunits
1823:β-subunits
1806:δ-subunits
991:References
682:infections
619:cell walls
352:beta turns
330:, and the
225:structures
3778:disorders
3776:see also
3559:Cytoplasm
3469:Aquaporin
2938:Anoctamin
2761:11.1/hERG
985:Aquaporin
928:1.B.24 -
886:1.B.54 -
882:Anaplasma
688:Discovery
669:mutations
608:Diversity
512:α
506:
471:α
465:
439:π
403:octameric
338:Structure
315:and some
289:molecules
135:PDOC00498
123:IPR001702
3572:Connexin
2852:minK/ISK
1533:24100136
1492:24683050
1484:12940978
1443:16321927
1354:11988218
1310:34974997
1193:23305369
1133:30437731
1125:14976314
1082:15519319
974:See also
870:Coxiella
755:1.B.6 -
395:monomers
376:nonpolar
305:channels
281:proteins
242:RCSB PDB
118:InterPro
58:
3699:Innexin
3456:solutes
1434:1317029
1266:8995393
1184:3706956
1105:Bibcode
1097:Science
1041:9615433
894:family
888:Intimin
861:1.B.39
856:1.B.35
851:1.B.34
839:1.B.31
832:1.B.25
827:1.B.24
818:1.B.21
809:1.B.18
804:1.B.17
795:1.B.14
789:1.B.13
783:1.B.12
776:1.B.10
602:daltons
577:in the
399:dimeric
387:aqueous
293:diffuse
203:cd01345
130:PROSITE
98:PF00267
36:sucrose
1996:-gated
1994:Proton
1770:T-type
1757:R-type
1744:Q-type
1724:P-type
1711:N-type
1676:L-type
1531:
1490:
1482:
1441:
1431:
1390:
1352:
1308:
1264:
1214:
1191:
1181:
1131:
1123:
1080:
1039:
1009:(MeSH)
1003:Porins
771:1.B.9
766:1.B.8
760:1.B.7
379:lipids
274:Porins
257:PDBsum
231:
221:
155:SUPFAM
111:CL0193
84:Symbol
18:Porins
3610:GJA10
3461:Porin
3361:TRPML
3131:HVCN1
2825:KCNIP
2680:α7-12
1584:TC 1A
1488:S2CID
1306:S2CID
1129:S2CID
680:from
492:and,
360:loops
167:1.B.1
151:SCOPe
142:SCOP2
3690:GJD4
3685:GJD3
3680:GJD2
3670:GJC3
3665:GJC2
3660:GJC1
3650:GJB7
3645:GJB6
3640:GJB5
3635:GJB4
3630:GJB3
3625:GJB2
3620:GJB1
3605:GJA9
3600:GJA8
3595:GJA5
3590:GJA4
3585:GJA3
3580:GJA1
3405:TRPV
3388:TRPP
3383:TRPN
3314:TRPM
3267:TRPC
3257:TRPA
3095:CLNS
3053:CLIC
3001:CLCN
2996:CFTR
2943:ANO1
2862:MiRP
2790:12.3
2785:12.2
2780:12.1
2771:11.3
2766:11.2
2752:10.2
2747:10.1
2537:α1-6
2351:GIRK
1765:α2.3
1752:α2.1
1719:α2.2
1529:PMID
1480:PMID
1439:PMID
1388:ISBN
1350:PMID
1338:1562
1262:PMID
1212:ISBN
1189:PMID
1121:PMID
1078:PMID
1064:1666
1037:PMID
702:TCDB
628:and
617:the
417:and
291:can
276:are
250:PDBj
246:PDBe
229:ECOD
219:Pfam
191:1pho
162:TCDB
147:1mpf
107:clan
105:Pfam
93:Pfam
55:1A0S
44:, a
3454:(+
3292:4AP
3205:HCN
2738:9.3
2733:9.2
2728:9.1
2719:8.2
2714:8.1
2705:7.5
2700:7.4
2695:7.3
2690:7.2
2685:7.1
2667:6.4
2662:6.3
2657:6.2
2652:6.1
2643:5.1
2634:4.3
2629:4.2
2624:4.1
2615:3.4
2610:3.3
2605:3.2
2600:3.1
2591:2.2
2586:2.1
2577:1.8
2572:1.7
2567:1.6
2562:1.5
2557:1.4
2552:1.3
2547:1.2
2542:1.1
2438:K2P
2418:7.1
2413:6.2
2408:6.1
2403:5.1
2398:4.2
2393:4.1
2378:3.4
2373:3.3
2368:3.2
2363:3.1
2344:2.6
2339:2.4
2334:2.3
2329:2.2
2324:2.1
2319:1.1
2305:ATP
2283:5.1
2278:4.2
2273:4.1
2268:3.1
2263:2.3
2258:2.2
2253:2.1
2248:1.1
2233:IK1
2223:SK3
2218:SK2
2213:SK1
2092:1.9
2087:1.8
2082:1.7
2077:1.6
2072:1.5
2067:1.4
2062:1.3
2057:1.2
2052:1.1
1941:Na:
1793:3.3
1788:3.2
1783:3.1
1737:2.1
1704:1.4
1699:1.3
1694:1.2
1689:1.1
1598:Ca:
1519:doi
1515:587
1470:doi
1429:PMC
1421:doi
1417:187
1380:doi
1342:doi
1298:doi
1252:doi
1248:272
1179:PMC
1171:doi
1113:doi
1101:303
1068:doi
1029:doi
1025:121
596:In
503:tan
462:cos
381:of
362:of
311:of
237:PDB
198:CDD
51:PDB
3794::
3676:D
3656:C
3616:B
3576:A
3458:):
3211:FC
3105:1B
3100:1A
3088:L1
3046:KB
3041:KA
2920:Cl
2513:18
2508:17
2503:16
2498:15
2493:13
2488:12
2483:10
2387:ir
2357:ir
2313:ir
2242:Ca
2201:β4
2196:β3
2191:β2
2186:β1
2181:α1
2153:K:
2104:Na
2097:7A
2043:Na
1870:γ4
1865:γ3
1860:γ2
1855:γ1
1843:β4
1838:β3
1833:β2
1828:β1
1774:Ca
1761:Ca
1748:Ca
1728:Ca
1715:Ca
1680:Ca
1578::
1527:.
1513:.
1509:.
1486:.
1478:.
1466:49
1464:.
1460:.
1437:.
1427:.
1415:.
1411:.
1386:.
1362:^
1348:.
1336:.
1318:^
1304:.
1292:.
1274:^
1260:.
1246:.
1242:.
1226:^
1187:.
1177:.
1167:13
1165:.
1161:.
1141:^
1127:.
1119:.
1111:.
1099:.
1076:.
1062:.
1058:.
1035:.
1023:.
684:.
621:.
581:.
248:;
244:;
227:/
179:31
153:/
149:/
53::
48:.
34:A
3561::
3541:3
3536:2
3531:1
3519:9
3514:8
3509:7
3504:6
3499:5
3494:4
3489:3
3484:2
3479:1
3474:0
3452:O
3450:2
3448:H
3435:6
3430:5
3425:4
3420:3
3415:2
3410:1
3398:2
3393:1
3376:3
3371:2
3366:1
3354:8
3349:7
3344:6
3339:5
3334:4
3329:3
3324:2
3319:1
3307:7
3302:6
3297:5
3287:4
3282:3
3277:2
3272:1
3263:)
3261:1
3259:(
3246::
3244:M
3231:4
3226:3
3221:2
3216:1
3197:3
3192:2
3187:1
3182:β
3175:4
3170:3
3165:2
3160:1
3155:α
3144::
3142:M
3120::
3118:H
3083:6
3078:5
3073:4
3068:3
3063:2
3058:1
3036:7
3031:6
3026:5
3021:4
3016:3
3011:2
3006:1
2987:4
2982:3
2977:2
2972:1
2960:2
2955:1
2922::
2877:3
2872:2
2867:1
2845:4
2840:3
2835:2
2830:1
2818:3
2813:2
2808:1
2803:β
2801:v
2799:K
2678:v
2676:K
2535:v
2533:K
2478:9
2473:7
2468:6
2463:5
2458:4
2453:3
2448:2
2443:1
2385:K
2355:K
2353:/
2311:K
2303:K
2240:K
2128:4
2123:3
2118:2
2113:1
2108:β
2106:v
2047:α
2045:v
2023:4
2018:3
2013:2
2008:1
1982:δ
1977:γ
1972:β
1967:α
1916:2
1911:1
1899:4
1894:3
1889:2
1884:1
1816:2
1811:1
1804:2
1802:α
1778:α
1776:v
1772:/
1763:v
1759:/
1750:v
1746:/
1732:α
1730:v
1726:/
1717:v
1713:/
1684:α
1682:v
1678:/
1656:3
1651:2
1646:1
1634:3
1629:2
1624:1
1586:)
1582:(
1568:e
1561:t
1554:v
1535:.
1521::
1494:.
1472::
1445:.
1423::
1396:.
1382::
1356:.
1344::
1312:.
1300::
1294:3
1268:.
1254::
1220:.
1195:.
1173::
1135:.
1115::
1107::
1084:.
1070::
1043:.
1031::
535:b
532:n
527:a
524:S
518:=
515:)
509:(
474:)
468:(
459:2
454:b
451:n
445:=
442:R
436:2
20:)
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