Knowledge (XXG)

Potassium nitrite

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277: 143: 24: 676: 538: 548: 1119:, a recently synthesized compound and one that his colleague had shown lowered blood pressure in animals. Pain associated with an anginal attack disappeared rapidly, and the effect lasted for several minutes, generally long enough for the patient to recover by resting. For a time, amyl nitrite was the favored treatment for angina, but due to its volatility, it was replaced by chemically related compounds that had the same effect. 543: 33: 671: 813: 1131:
ensued. They also noted that potassium nitrite, however administered, had a profound effect on the appearance and oxygen-carrying capacity of the blood. They compared the biological action of potassium nitrite with that of amyl and ethyl nitrites and concluded that the similarity of action depends on
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Potassium nitrite forms potassium nitrate when heated in the presence of oxygen from 550 °C to 790 °C. The rate of reaction increases with temperature, but the extent of reaction decreases. At 550 °C and 600 °C the reaction is continuous and eventually goes to completion. From 650 °C to 750 °C, as
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The effect of potassium nitrite on the nervous system, brain, spinal cord, pulse, arterial blood pressure, and respiration of healthy human volunteers was noted, as was the variability between individuals. The most significant observation was that even a small dose of <0.5 grains (≈30 mg)
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and wrongly concluded that the pain must be due to elevated blood pressure. As a treatment for angina, the reduction of circulating blood by venesection was inconvenient. Therefore, he decided to try the effect on a patient of inhaling
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Wollin, Goesta; William B.F. Ryan (May 16, 1979). "Synthesis of protein, nucleosides and other organic compounds from cyanamide and potassium nitrite under possible primitive earth conditions".
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is not employed on a large scale because of the high price of these alkalies. Furthermore, the fact that potassium nitrite is highly soluble in water makes the solid difficult to recover.
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Interest in a medical role for inorganic nitrite was first aroused because of the spectacular success of organic nitrites and related compounds in the treatment of
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is present at trace levels in soil, natural waters, plant and animal tissues, and fertilizer. The pure form of nitrite was first made by the Swedish chemist
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Freeman, Eli (Feb 20, 1957). "The Kinetics of the Thermal Decomposition of Potassium Nitrate and of the Reaction between Potassium Nitrite and Oxygen".
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at red heat for half an hour and obtained what he recognized as a new “salt.” The two compounds (potassium nitrate and nitrite) were characterized by
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Potassium nitrite can be obtained by the reduction of potassium nitrate. The production of potassium nitrite by absorption of nitrogen oxides in
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It is a strong oxidizer and may accelerate the combustion of other materials. Like other nitrite salts such as
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and ammonia gases. No external energy is used and the reactions are carried out with a small amount of O
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Potassium nitrite is stored with other oxidizing agents but separated from flammables, combustibles,
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and is approved for usage in the EU, USA, Australia and New Zealand (where it is listed under its
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studies, and the same reaction mechanism has been proposed to explain the biological action of
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Solutions of acidified nitrite have been used successfully to generate NO and to induce
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produces changes from white solids to yellow liquid and then to orange solid, forming
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Potassium nitrite reacts at an extremely slow rate with a liquid ammonia solution of
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When reacting with acids, potassium nitrite forms toxic nitrous oxides. Fusion with
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Potassium nitrite is used in the manufacturing of heat transfer salts. As
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Santa Cruz Biotechnology. "Potassium Nitrite Materials and Safety Sheet".
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in the 1860s, Brunton noted that the pain of angina could be lessened by
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the case of decomposition of potassium nitrate is, the system attains
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Except where otherwise noted, data are given for materials in their
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working in the laboratory of his pharmacy in the market town of
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440.02 °C (824.04 °F; 713.17 K) (decomposes)
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given by mouth caused, at first, an increase in arterial
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Biochimica et Biophysica Acta (BBA) - General Subjects
890:, which forms a white or slightly yellow, hygroscopic 945: 169: 2539: 2195: 2088: 1927: 1673: 1559: 1404:"Current EU approved additives and their E Numbers" 1301:"Therapeutic Uses of Inorganic Nitrite and Nitrate" 1015: 411:537 °C (999 °F; 810 K) (explodes) 196: 673: 55: 1016:{\displaystyle {\ce {2KNO3 -> 2KNO2 + O2}}} 1537: 1299:Butler, Anthony R.; Feelisch, Martin (2008). 1082:at room temperatures, and in the presence of 8: 1475:Division of Chemical Education (June 2008). 1452:"Standard 1.2.4 - Labelling of ingredients" 1544: 1530: 1522: 1425:"Listing of Food Additives Status Part II" 300:InChI=1S/K.HNO2/c;2-1-3/h;(H,2,3)/q+1;/p-1 275: 141: 119: 15: 1449:Australia New Zealand Food Standards Code 1316: 1008: 1003: 992: 987: 982: 964: 960: 955: 950: 946: 944: 310:InChI=1/K.HNO2/c;2-1-3/h;(H,2,3)/q+1;/p-1 232: 2343: 2339: 2305: 2301: 2291: 2233: 2229: 1377:Journal of the American Chemical Society 870: 1252: 1246:International Chemical Safety Card 1069 331: 296: 271: 1274: 1263: 1132:the conversion of organic nitrites to 132: 936:and the reaction was established as: 303:Key: BXNHTSHTPBPRFX-UHFFFAOYSA-M 99: 7: 1106:. While working with Butter at the 313:Key: BXNHTSHTPBPRFX-REWHXWOFAI 187: 970: 14: 1422:US Food and Drug Administration: 1318:10.1161/CIRCULATIONAHA.107.753814 894:powder that is soluble in water. 811: 546: 541: 536: 31: 22: 807:(at 25 °C , 100 kPa). 1: 1481:Journal of Chemical Education 377:white or slight yellow solid 1430:Food and Drug Administration 1354:10.1016/0304-4165(79)90122-3 369:85.10379 g/mol 731:or concentration (LD, LC): 2743: 1401:UK Food Standards Agency: 1166:, potassium nitrite is a 1108:Edinburgh Royal Infirmary 801: 766: 727: 517: 512: 461: 342: 322: 287: 39: 30: 21: 593:Precautionary statements 1090:, to form nitrogen and 451:Magnetic susceptibility 1075:of potassium nitrite. 1017: 680: 457:−23.3·10 cm/mol 427:413 g/100 mL (100 °C) 1018: 679: 425:312 g/100 mL (25 °C) 1202:Storage requirements 943: 922:Carl Wilhelm Scheele 662:(fire diamond) 423:281 g/100 mL (0 °C) 2707:Potassium compounds 1560:H, (pseudo)halogens 1553:Potassium compounds 1493:2008JChEd..85..779Y 1477:"Potassium Nitrite" 1389:10.1021/ja01561a015 1092:potassium hydroxide 1037:potassium carbonate 1033:potassium hydroxide 1011: 995: 976: 963: 418:Solubility in water 18: 2727:E-number additives 1454:. 8 September 2011 1182:Reactivity hazards 1013: 999: 983: 951: 854:inorganic compound 834:Infobox references 767:Related compounds 681: 17:Potassium nitrite 16: 2694: 2693: 2196:transition metals 1501:10.1021/ed085p779 1311:(16): 2151–2159. 1273:Missing or empty 1229:Potassium nitrate 1190:salts results in 1002: 986: 977: 954: 930:potassium nitrate 850:potassium nitrate 846:Potassium nitrite 842:Chemical compound 840: 839: 781:Potassium nitrate 755:Safety data sheet 571:Hazard statements 256:CompTox Dashboard 81:Interactive image 2734: 2717:Oxidizing agents 2346: 2332: 2331: 2330: 2322: 2321: 2308: 2294: 2284: 2283: 2282: 2274: 2273: 2236: 1546: 1539: 1532: 1523: 1516: 1515: 1513: 1512: 1503:. Archived from 1472: 1463: 1462: 1460: 1459: 1447: 1441: 1440: 1438: 1437: 1420: 1414: 1413: 1411: 1410: 1399: 1393: 1392: 1372: 1366: 1365: 1337: 1331: 1330: 1320: 1296: 1283: 1282: 1276: 1271: 1269: 1261: 1257: 1022: 1020: 1019: 1014: 1012: 1010: 1007: 1000: 994: 991: 984: 978: 965: 962: 959: 952: 873: 858:chemical formula 824: 818: 815: 814: 708: 701: 694: 687: 672: 652: 648: 644: 640: 636: 632: 628: 624: 620: 616: 612: 608: 604: 600: 586: 582: 578: 550: 545: 540: 504: 477: 462:Thermochemistry 350:Chemical formula 280: 279: 264: 262: 236: 200: 189: 171: 153: 145: 134: 123: 103: 83: 59: 35: 26: 19: 2742: 2741: 2737: 2736: 2735: 2733: 2732: 2731: 2697: 2696: 2695: 2690: 2686: 2682: 2678: 2670: 2666: 2662: 2654: 2650: 2646: 2642: 2634: 2630: 2626: 2618: 2614: 2610: 2602: 2598: 2590: 2586: 2582: 2574: 2570: 2562: 2558: 2550: 2535: 2531: 2527: 2523: 2515: 2511: 2507: 2499: 2495: 2491: 2483: 2479: 2475: 2466: 2458: 2454: 2446: 2442: 2434: 2430: 2422: 2414: 2410: 2402: 2398: 2390: 2386: 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1242: 1220: 1208:reducing agents 1204: 1184: 1157: 1104:angina pectoris 1100: 1080:potassium amide 1062: 1054: 1045: 1029: 941: 940: 915: 889: 872: 860: 848:(distinct from 843: 836: 831: 830: 829:  ?) 820: 816: 812: 808: 792: 777: 746: 740: 713: 712: 711: 710: 703: 696: 689: 682: 678: 670: 595: 573: 559: 533: 505: 502: 496: 492: 489: 488:Std enthalpy of 478: 471: 454: 426: 424: 420: 378: 358: 352: 338: 335: 330: 329: 318: 315: 314: 311: 305: 304: 301: 295: 294: 283: 265: 258: 239: 219: 203: 190: 177:(preservatives) 163: 126: 106: 86: 73: 62: 49: 12: 11: 5: 2740: 2738: 2730: 2729: 2724: 2719: 2714: 2709: 2699: 2698: 2692: 2691: 2689: 2688: 2684: 2680: 2676: 2672: 2668: 2664: 2660: 2656: 2652: 2648: 2644: 2640: 2636: 2632: 2628: 2624: 2620: 2616: 2612: 2608: 2604: 2600: 2596: 2592: 2588: 2584: 2580: 2576: 2572: 2568: 2564: 2560: 2556: 2552: 2548: 2543: 2541: 2537: 2536: 2534: 2533: 2529: 2525: 2521: 2517: 2513: 2509: 2505: 2501: 2497: 2493: 2489: 2485: 2481: 2477: 2473: 2469: 2464: 2460: 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723:Non-flammable 721: 715: 714: 704: 697: 690: 683: 668: 667: 666: 665: 663: 654: 653: 596: 591: 588: 587: 574: 569: 566: 565: 560: 555: 552: 551: 534: 529: 526: 525: 515: 514: 510: 509: 508:-369.8 kJ/mol 506: 500: 494: 486: 483: 482: 481:107.4 J/mol K 479: 467: 464: 463: 459: 458: 455: 449: 446: 445: 435: 429: 428: 421: 416: 413: 412: 409: 403: 402: 399: 393: 392: 391:1.914986 g/cm 389: 383: 382: 375: 371: 370: 367: 361: 360: 356: 353: 348: 345: 344: 340: 339: 337: 336: 333: 325: 324: 323: 320: 319: 317: 316: 312: 309: 308: 306: 302: 299: 298: 290: 289: 288: 285: 284: 282: 281: 268: 266: 254: 251: 250: 247: 241: 240: 238: 237: 229: 227: 221: 220: 218: 217: 213: 211: 205: 204: 202: 201: 193: 191: 183: 180: 179: 173: 165: 164: 162: 161: 157: 155: 147: 146: 136: 128: 127: 125: 124: 116: 114: 108: 107: 105: 104: 96: 94: 88: 87: 85: 84: 76: 74: 67: 64: 63: 61: 60: 52: 50: 45: 42: 41: 37: 36: 28: 27: 13: 10: 9: 6: 4: 3: 2: 2739: 2728: 2725: 2723: 2722:Preservatives 2720: 2718: 2715: 2713: 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1076: 1074: 1073:decomposition 1070: 1064: 1058: 1050: 1042: 1040: 1038: 1034: 1026: 1004: 996: 988: 979: 973: 966: 956: 947: 939: 938: 937: 935: 931: 927: 923: 919: 912: 910: 908: 904: 900: 895: 893: 885: 881: 877: 869: 866: 863: 859: 855: 851: 847: 835: 828: 823: 806: 800: 797: 794: 791: 786: 785: 782: 779: 776: 771: 770: 765: 762: 761:External MSDS 759: 756: 753: 752: 748: 744: 735: 734: 730: 726: 722: 720: 717: 716: 709: 702: 695: 688: 664: 661: 660: 656: 655: 597: 594: 590: 589: 575: 572: 568: 567: 564: 561: 558: 554: 553: 549: 544: 539: 535: 532: 528: 527: 523: 521: 516: 511: 507: 499: 491: 485: 484: 480: 475: 470: 469:Heat capacity 466: 465: 460: 456: 452: 448: 447: 444: 440: 436: 434: 431: 430: 422: 419: 415: 414: 410: 408: 407:Boiling point 405: 404: 400: 398: 397:Melting point 395: 394: 390: 388: 385: 384: 381: 376: 373: 372: 368: 366: 363: 362: 354: 351: 347: 346: 341: 332: 328: 321: 307: 297: 293: 286: 278: 274: 273:DTXSID5042320 270: 269: 267: 257: 253: 252: 248: 246: 243: 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Retrieved 1505:the original 1484: 1480: 1456:. Retrieved 1445: 1434:. Retrieved 1428: 1418: 1407:. Retrieved 1397: 1380: 1376: 1370: 1345: 1341: 1335: 1308: 1304: 1255: 1205: 1185: 1168:preservative 1158: 1145:blood vessel 1143:in isolated 1138: 1134:nitrous acid 1121: 1117:amyl nitrite 1101: 1098:Medical uses 1084:ferric oxide 1077: 1065: 1046: 1030: 928:. He heated 916: 896: 845: 844: 728: 658: 562: 519: 497: 473: 380:deliquescent 209:RTECS number 40:Identifiers 1305:Circulation 1170:similar to 1129:hypotension 1112:venesection 1069:equilibrium 907:teratogenic 892:crystalline 882:ions K and 874:. It is an 743:median dose 729:Lethal dose 719:Flash point 557:Signal word 437:soluble in 374:Appearance 343:Properties 139:100.028.939 2701:Categories 2089:B, C group 1928:pnictogens 1674:chalcogens 1511:2012-06-22 1487:(6): 779. 1458:2011-10-27 1436:2011-10-27 1409:2011-10-27 1275:|url= 1176:INS number 1155:Other uses 1027:Production 876:ionic salt 749:235 mg/kg 531:Pictograms 433:Solubility 365:Molar mass 234:794654G42L 112:ChemSpider 68:3D model ( 47:CAS Number 1210:, acids, 1049:cyanamide 1043:Reactions 971:Δ 913:Discovery 903:mutagenic 880:potassium 856:with the 852:) is the 639:P370+P378 627:P301+P310 522:labelling 490:formation 245:UN number 216:TT3750000 160:231-832-4 152:EC Number 57:7758-09-0 2712:Nitrites 1327:18427145 1266:cite web 1218:See also 1212:cyanides 1196:ignition 1188:ammonium 1057:cyanogen 967:→ 659:NFPA 704 513:Hazards 453:(χ) 170:E number 2540:organic 1489:Bibcode 1234:Nitrite 1149:nitrite 1051:and KNO 934:Péligot 918:Nitrite 886:ions NO 884:nitrite 827:what is 825: ( 790:cations 443:ammonia 439:alcohol 387:Density 359: 185:PubChem 2367:Fe(CN) 2355:Fe(CN) 2219:Pt(CN) 1362:454677 1360:  1325:  1178:249). 926:Köping 822:verify 819:  788:Other 775:anions 773:Other 757:(SDS) 563:Danger 327:SMILES 198:516910 92:ChEMBL 292:InChI 249:1488 175:E249 121:22857 70:JSmol 2547:KHCO 2463:KCrO 2419:KMnO 2379:Fe(C 2304:ReBr 2290:KAsF 2257:ReCl 2245:PtCl 2207:PtCl 2124:KHCO 2065:HAsO 2041:KAsO 1777:KHSO 1769:KHSO 1749:KHSO 1665:KSCN 1660:KOCN 1655:KCNO 1616:KBrO 1603:KClO 1595:KClO 1590:KClO 1358:PMID 1323:PMID 1279:help 1194:and 1164:E249 651:P501 647:P405 643:P391 635:P330 631:P321 623:P280 619:P273 615:P270 611:P264 607:P221 603:P220 599:P210 585:H400 581:H301 577:H272 334:.N=O 225:UNII 2595:KHC 2567:KCF 2555:KCH 2455:CrO 2443:CrO 2431:CrO 2411:MnO 2399:FeO 2342:ZrF 2323:ReI 2275:ReF 2232:TiF 2148:SiF 2136:SiO 2077:AsO 2053:AsO 2033:KPF 2013:HPO 1968:KNO 1960:KNO 1944:KNH 1907:TeO 1895:TeO 1874:SeO 1862:SeO 1732:KHS 1690:KOH 1650:KCN 1645:KAt 1637:KIO 1629:KIO 1611:KBr 1585:KCl 1572:KHF 1497:doi 1385:doi 1350:doi 1346:584 1313:doi 1309:117 1086:or 1035:or 985:KNO 953:KNO 905:or 878:of 520:GHS 501:298 355:KNO 261:EPA 188:CID 2703:: 2683:KO 2667:KO 2629:35 2625:18 2623:KC 2613:23 2609:12 2607:KC 2571:CO 2559:CO 2528:Cl 2524:Mo 2514:13 2508:Cr 2498:10 2492:Cr 2476:Cr 2467:Cl 2176:Al 2160:Al 2116:CO 2073:KH 2025:PO 2021:KH 2001:PO 1989:PO 1985:KH 1952:KN 1919:Po 1886:Te 1853:Se 1761:SO 1741:SO 1715:KO 1707:KO 1624:KI 1580:KH 1567:KF 1495:. 1485:85 1483:. 1479:. 1467:^ 1427:. 1381:79 1379:. 1356:. 1344:. 1321:. 1307:. 1303:. 1287:^ 1270:: 1268:}} 1264:{{ 1151:. 1136:. 1094:. 1063:. 739:50 737:LD 707:OX 649:, 645:, 641:, 637:, 633:, 629:, 625:, 621:, 617:, 613:, 609:, 605:, 601:, 583:, 579:, 524:: 493:(Δ 441:, 2685:4 2681:7 2679:H 2677:5 2675:C 2669:4 2665:6 2663:H 2661:4 2659:C 2653:4 2651:O 2649:2 2647:K 2645:2 2643:H 2641:3 2639:C 2633:2 2631:O 2627:H 2617:2 2615:O 2611:H 2601:4 2599:O 2597:2 2589:4 2587:O 2585:2 2583:C 2581:2 2579:K 2573:2 2569:3 2561:2 2557:3 2549:2 2530:8 2526:2 2522:4 2520:K 2512:O 2510:4 2506:2 2504:K 2496:O 2494:3 2490:2 2488:K 2482:7 2480:O 2478:2 2474:2 2472:K 2465:3 2457:8 2453:3 2451:K 2445:4 2441:2 2439:K 2433:4 2429:3 2427:K 2421:4 2413:4 2409:2 2407:K 2401:4 2397:2 2395:K 2389:3 2387:) 2385:4 2383:O 2381:2 2377:3 2375:K 2369:6 2365:3 2363:K 2357:6 2353:4 2351:K 2344:6 2340:2 2338:K 2328:6 2319:2 2314:K 2306:6 2302:2 2300:K 2292:6 2280:6 2271:2 2266:K 2259:6 2255:2 2253:K 2247:6 2243:2 2241:K 2234:6 2230:2 2228:K 2221:4 2217:2 2215:K 2209:4 2205:2 2203:K 2186:7 2184:O 2182:2 2180:B 2178:2 2174:2 2172:K 2166:4 2164:O 2162:2 2158:2 2156:K 2150:6 2146:2 2144:K 2138:3 2134:2 2132:K 2126:3 2118:3 2114:2 2112:K 2106:7 2104:O 2102:2 2100:K 2098:4 2096:B 2079:4 2075:2 2067:4 2063:2 2061:K 2055:4 2051:3 2049:K 2043:2 2035:6 2027:4 2023:2 2015:4 2011:2 2009:K 2003:4 1999:3 1997:K 1991:3 1987:2 1980:P 1978:3 1976:K 1970:3 1962:2 1954:3 1946:2 1939:N 1937:3 1935:K 1917:2 1915:K 1909:4 1905:2 1903:K 1897:3 1893:2 1891:K 1884:2 1882:K 1876:4 1872:2 1870:K 1864:3 1860:2 1858:K 1851:2 1849:K 1843:8 1841:O 1839:2 1837:S 1835:2 1833:K 1827:7 1825:O 1823:2 1821:S 1819:2 1817:K 1811:5 1809:O 1807:2 1805:S 1803:2 1801:K 1795:3 1793:O 1791:2 1789:S 1787:2 1785:K 1779:5 1771:4 1763:4 1759:2 1757:K 1751:3 1743:3 1739:2 1737:K 1727:S 1725:2 1723:K 1717:3 1709:2 1701:2 1699:O 1697:2 1695:K 1685:O 1683:2 1681:K 1639:4 1631:3 1618:3 1605:4 1597:3 1574:2 1545:e 1538:t 1531:v 1514:. 1499:: 1491:: 1461:. 1439:. 1412:. 1391:. 1387:: 1364:. 1352:: 1329:. 1315:: 1281:) 1277:( 1061:2 1053:2 1005:2 1001:O 997:+ 989:2 980:2 974:T 957:3 948:2 888:2 871:2 868:O 865:N 862:K 817:Y 745:) 741:( 700:2 693:0 686:3 503:) 498:H 495:f 476:) 474:C 472:( 357:2 263:) 259:( 72:)

Index



CAS Number
7758-09-0
JSmol
Interactive image
ChEMBL
ChEMBL3186418
ChemSpider
22857
ECHA InfoCard
100.028.939
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EC Number
E number
(preservatives)
PubChem
516910
RTECS number
UNII
794654G42L
UN number
CompTox Dashboard
DTXSID5042320
Edit this at Wikidata
InChI
SMILES
Chemical formula
Molar mass
deliquescent

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