220:
29:
335:
InChI=1S/C45H55N9O6/c1-27(47)41(56)52-38(24-30-19-20-31-14-6-7-15-32(31)22-30)43(58)50-28(2)42(57)53-39(25-33-26-49-35-17-9-8-16-34(33)35)45(60)54-37(23-29-12-4-3-5-13-29)44(59)51-36(40(48)55)18-10-11-21-46/h3-9,12-17,19-20,22,26-28,36-39,49H,10-11,18,21,23-25,46-47H2,1-2H3,(H2,48,55)(H,50,58)(H,51,59)(H,52,56)(H,53,57)(H,54,60)/t27-,28+,36+,37-,38-,39+/m1/s1
1862:
293:
502:
for these indications, but was ultimately never marketed for them. This may be because the ability of pralmorelin to increase plasma GH levels is significantly lower in people with GHD relative to healthy individuals.
1196:
1942:
1903:
1189:
674:
Furuta S, Shimada O, Doi N, Ukai K, Nakagawa T, Watanabe J, Imaizumi M (2004). "General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide".
567:
Moulin A, Brunel L, Verdié P, Gavara L, Martinez J, Fehrentz JA (2014). "Ghrelin
Receptor Ligands: Design and Synthesis of Pseudopeptides and Peptidomimetics".
1205:
1947:
307:
532:
1182:
783:
1843:
1896:
1545:
1932:
616:
1889:
1625:
512:
462:
469:, and was the first of this class of drugs to be introduced clinically. Acute administration of the drug markedly increases the levels of
1927:
354:
327:
639:
Adis
Editorial (2004). "Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN".
1580:
776:
69:
1368:
1099:
533:"The Year's New Drugs: A Historical and Research Perspective on the 41 New Products that Reached their First Markets in 2005"
1076:
179:
1081:
496:
398:
199:
769:
386:
414:
1922:
1278:
1268:
148:
1226:
49:
1258:
406:
378:
315:
C(C(=O)N(CC1=CC2=CC=CC=C2C=C1)C(=O)N(C)C(=O)N(CC3=CNC4=CC=CC=C43)C(=O)N(CC5=CC=CC=C5)C(=O)N(CCCCN)C(=O)N)N
1485:
1383:
139:
1525:
1303:
1828:
1804:
1253:
892:
837:
215:
1650:
1410:
1243:
1799:
1585:
1465:
1248:
443:
421:
94:
1645:
1510:
1535:
1445:
1425:
1358:
1323:
1313:
1283:
1218:
1144:
937:
699:
492:
1705:
1590:
1530:
1415:
1333:
1328:
1293:
717:
MĂĽller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, et al. (June 2015).
1784:
1779:
1762:
1752:
1710:
1575:
1565:
1520:
1475:
1435:
1430:
1400:
1343:
606:
1937:
1794:
1655:
1615:
1273:
872:
814:
792:
748:
691:
656:
612:
584:
544:
435:
1873:
1818:
1813:
1495:
1490:
168:
1685:
1680:
1675:
1670:
1500:
1470:
1405:
1002:
738:
730:
683:
648:
576:
425:
402:
236:
103:
188:
1869:
1011:
981:
976:
932:
905:
219:
1263:
1215:
1149:
1131:
1040:
947:
743:
718:
499:
473:
439:
44:
D-Alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
580:
1916:
1174:
652:
488:
703:
128:
1747:
1480:
1298:
1113:
1027:
952:
796:
470:
734:
1767:
1725:
1720:
1700:
1605:
1600:
1460:
1420:
1348:
1288:
1091:
1056:
971:
827:
481:
1757:
1742:
1730:
1695:
1660:
1595:
1505:
1455:
1450:
1440:
1318:
1163:
1121:
1051:
1032:
867:
269:
159:
588:
548:
1772:
1737:
1158:
1139:
942:
900:
877:
856:
845:
805:
20:
752:
695:
687:
660:
859:
761:
1570:
1308:
1021:
988:
963:
928:
923:
882:
81:)-6-Amino-2-amino]-3-naphthalen-2-ylpropanoyl]amino]propanoyl]amino]-3-(1
28:
1665:
1068:
915:
822:
466:
428:
114:
1861:
487:
Pralmorelin was also under investigation for the treatment of GHD and
1690:
1154:
477:
410:
292:
283:
431:
1178:
765:
85:-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
204:
608:
Endocrinology: Adult and
Pediatric: Expert Consult - Online
1384:
1546:
1877:
1369:
1829:
1210:
1827:
1626:
1624:
1544:
1382:
1225:
1130:
1112:
1090:
1067:
1010:
1001:
961:
914:
891:
855:
836:
813:
804:
634:
632:
630:
628:
413:in a single-dose formulation for the assessment of
281:
268:
235:
230:
198:
178:
158:
147:
138:
113:
93:
60:
48:
40:
35:
600:
598:
562:
560:
558:
1279:Placental growth hormone (growth hormone variant)
127:
102:
1943:World Anti-Doping Agency prohibited substances
1897:
1190:
777:
8:
611:. Elsevier Health Sciences. pp. 1366–.
605:Jameson JL, De Groot LJ (25 February 2015).
463:ghrelin/growth hormone secretagogue receptor
19:
1904:
1890:
1197:
1183:
1175:
1007:
810:
784:
770:
762:
218:
167:
742:
187:
476:(GH) and reliably induces sensations of
523:
332:
312:
214:
74:
1374:Tooltip Growth hormone-binding protein
1227:
1206:
18:
7:
1858:
1856:
513:List of growth hormone secretagogues
1948:Systemic hormonal preparation stubs
118:
1876:. You can help Knowledge (XXG) by
391:growth hormone-releasing peptide 2
361:; former developmental code names
14:
581:10.2174/2212796807999131128125920
1860:
653:10.2165/00126839-200405040-00011
253:
247:
27:
340:Key:HRNLPPBUBKMZMT-RDRUQFPZSA-N
1319:Somatrogon (MOD-4023; hGH-CTP)
259:
241:
1:
1933:Growth hormone secretagogues
735:10.1016/j.molmet.2015.03.005
537:Drug News & Perspectives
1356:Antisense oligonucleotides:
531:Graul AI, Prous JR (2006).
399:growth hormone secretagogue
383:pralmorelin dihydrochloride
1964:
1855:
231:Chemical and physical data
1928:Ghrelin receptor agonists
948:Methylthioninium chloride
893:Liver functional capacity
415:growth hormone deficiency
375:pralmorelin hydrochloride
323:
303:
65:
26:
1269:Human placental lactogen
569:Current Chemical Biology
389:), as well as, notably,
1661:Examorelin (hexarelin)
1092:Fertility disturbances
938:Cation exchange resins
688:10.1055/s-0031-1297042
676:Arzneimittel-Forschung
453:-(β-naphthyl)-Ala-Trp-
1164:Phenolsulfonphthalein
1870:hormonal preparation
1716:Pralmorelin (GHRP-2)
1259:Eftansomatropin alfa
723:Molecular Metabolism
407:Kaken Pharmaceutical
405:that is marketed by
1758:Ibutamoren (MK-677)
1586:Modified GRF (1-29)
1486:Somatostatin (1-28)
1481:Somatostatin (GHIH)
1249:Bovine somatotropin
964:pancreatic function
943:Histamine phosphate
906:Sulfobromophthalein
444:amino acid sequence
434:, specifically, an
23:
1145:Aminohippuric acid
495:), and made it to
493:pituitary dwarfism
420:Pralmorelin is an
1885:
1884:
1853:
1852:
1835:
1808:
1632:
1552:
1526:Cyclosomatostatin
1390:
1366:Binding proteins:
1274:Lonapegsomatropin
1233:
1172:
1171:
1108:
1107:
997:
996:
916:Gastric secretion
873:Magnesium sulfate
618:978-0-323-32195-2
456:
452:
448:
373:), also known as
348:
347:
294:Interactive image
200:CompTox Dashboard
56:Oral, intravenous
16:Chemical compound
1955:
1906:
1899:
1892:
1864:
1857:
1833:
1831:
1806:
1630:
1628:
1550:
1548:
1388:
1386:
1375:
1371:
1304:Somatropin pegol
1231:
1229:
1212:
1208:
1199:
1192:
1185:
1176:
1069:Thyroid function
1008:
1003:Endocrine system
811:
806:Digestive system
786:
779:
772:
763:
757:
756:
746:
714:
708:
707:
671:
665:
664:
641:Drugs in R&D
636:
623:
622:
602:
593:
592:
564:
553:
552:
528:
454:
450:
446:
403:diagnostic agent
401:(GHS) used as a
296:
276:
261:
255:
249:
243:
223:
222:
208:
206:
191:
171:
151:
131:
121:
120:
106:
31:
24:
22:
1963:
1962:
1958:
1957:
1956:
1954:
1953:
1952:
1923:Abandoned drugs
1913:
1912:
1911:
1910:
1854:
1849:
1832:
1823:
1629:
1620:
1549:
1540:
1387:
1378:
1373:
1254:Efpegsomatropin
1230:
1221:
1203:
1173:
1168:
1126:
1104:
1086:
1063:
993:
982:cholecystokinin
957:
933:sodium benzoate
910:
887:
851:
832:
800:
790:
760:
716:
715:
711:
682:(12): 868–880.
673:
672:
668:
638:
637:
626:
619:
604:
603:
596:
566:
565:
556:
530:
529:
525:
521:
509:
500:clinical trials
461:. It acts as a
460:
344:
341:
336:
331:
330:
319:
316:
311:
310:
299:
274:
264:
258:
252:
246:
226:
216:DTXSID601032404
202:
194:
174:
154:
134:
117:
109:
89:
86:
73:
72:
51:
17:
12:
11:
5:
1961:
1959:
1951:
1950:
1945:
1940:
1935:
1930:
1925:
1915:
1914:
1909:
1908:
1901:
1894:
1886:
1883:
1882:
1865:
1851:
1850:
1848:
1847:
1839:
1837:
1825:
1824:
1822:
1821:
1816:
1811:
1802:
1797:
1788:
1787:
1782:
1770:
1765:
1760:
1755:
1750:
1745:
1740:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1651:Cortistatin-14
1648:
1636:
1634:
1622:
1621:
1619:
1618:
1609:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1556:
1554:
1551:(somatocrinin)
1542:
1541:
1539:
1538:
1533:
1528:
1523:
1514:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1411:Cortistatin-14
1408:
1403:
1394:
1392:
1389:(somatostatin)
1380:
1379:
1377:
1376:
1362:
1361:
1352:
1351:
1346:
1337:
1336:
1331:
1326:
1321:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1264:Growth hormone
1261:
1256:
1251:
1246:
1244:Albusomatropin
1237:
1235:
1232:(somatotropin)
1223:
1222:
1204:
1202:
1201:
1194:
1187:
1179:
1170:
1169:
1167:
1166:
1161:
1159:polyfructosans
1152:
1150:Indigo carmine
1147:
1142:
1136:
1134:
1132:Renal function
1128:
1127:
1125:
1124:
1118:
1116:
1110:
1109:
1106:
1105:
1103:
1102:
1096:
1094:
1088:
1087:
1085:
1084:
1079:
1073:
1071:
1065:
1064:
1062:
1061:
1060:
1059:
1054:
1049:
1037:
1036:
1035:
1030:
1017:
1015:
1005:
999:
998:
995:
994:
992:
991:
986:
985:
984:
974:
968:
966:
959:
958:
956:
955:
950:
945:
940:
935:
926:
920:
918:
912:
911:
909:
908:
903:
897:
895:
889:
888:
886:
885:
880:
875:
870:
864:
862:
853:
852:
850:
849:
842:
840:
838:Fat absorption
834:
833:
831:
830:
825:
819:
817:
808:
802:
801:
791:
789:
788:
781:
774:
766:
759:
758:
729:(6): 437–460.
709:
666:
647:(4): 236–239.
624:
617:
594:
575:(3): 254–270.
554:
522:
520:
517:
516:
515:
508:
505:
480:and increases
474:growth hormone
458:
440:met-enkephalin
359:GHRP Kaken 100
357:) (brand name
346:
345:
343:
342:
339:
337:
334:
326:
325:
324:
321:
320:
318:
317:
314:
306:
305:
304:
301:
300:
298:
297:
289:
287:
279:
278:
272:
266:
265:
262:
256:
250:
244:
239:
233:
232:
228:
227:
225:
224:
211:
209:
196:
195:
193:
192:
184:
182:
176:
175:
173:
172:
164:
162:
156:
155:
153:
152:
144:
142:
136:
135:
133:
132:
124:
122:
111:
110:
108:
107:
99:
97:
91:
90:
88:
87:
76:
68:
67:
66:
63:
62:
58:
57:
54:
52:administration
46:
45:
42:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1960:
1949:
1946:
1944:
1941:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1920:
1918:
1907:
1902:
1900:
1895:
1893:
1888:
1887:
1881:
1879:
1875:
1872:article is a
1871:
1866:
1863:
1859:
1845:
1841:
1840:
1838:
1836:
1834:(somatomedin)
1826:
1820:
1817:
1815:
1812:
1810:
1809:-LysÂł)-GHRP-6
1803:
1801:
1800:Cortistatin-8
1798:
1796:
1793:
1790:
1789:
1786:
1783:
1781:
1778:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1754:
1751:
1749:
1746:
1744:
1741:
1739:
1736:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1641:
1638:
1637:
1635:
1633:
1623:
1617:
1614:
1611:
1610:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1561:
1558:
1557:
1555:
1553:
1543:
1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
1516:
1515:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1466:Pentetreotide
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1396:
1395:
1393:
1391:
1381:
1372:
1367:
1364:
1363:
1360:
1357:
1354:
1353:
1350:
1347:
1345:
1342:
1339:
1338:
1335:
1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
1250:
1247:
1245:
1242:
1239:
1238:
1236:
1234:
1224:
1220:
1217:
1214:
1200:
1195:
1193:
1188:
1186:
1181:
1180:
1177:
1165:
1162:
1160:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1137:
1135:
1133:
1129:
1123:
1120:
1119:
1117:
1115:
1111:
1101:
1098:
1097:
1095:
1093:
1089:
1083:
1080:
1078:
1075:
1074:
1072:
1070:
1066:
1058:
1055:
1053:
1050:
1048:
1045:
1044:
1043:
1042:
1038:
1034:
1031:
1029:
1026:
1025:
1024:
1023:
1019:
1018:
1016:
1013:
1009:
1006:
1004:
1000:
990:
987:
983:
980:
979:
978:
975:
973:
970:
969:
967:
965:
960:
954:
951:
949:
946:
944:
941:
939:
936:
934:
930:
927:
925:
922:
921:
919:
917:
913:
907:
904:
902:
899:
898:
896:
894:
890:
884:
881:
879:
876:
874:
871:
869:
866:
865:
863:
861:
858:
854:
847:
844:
843:
841:
839:
835:
829:
826:
824:
821:
820:
818:
816:
812:
809:
807:
803:
798:
794:
787:
782:
780:
775:
773:
768:
767:
764:
754:
750:
745:
740:
736:
732:
728:
724:
720:
713:
710:
705:
701:
697:
693:
689:
685:
681:
677:
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667:
662:
658:
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650:
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635:
633:
631:
629:
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614:
610:
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586:
582:
578:
574:
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555:
550:
546:
542:
538:
534:
527:
524:
518:
514:
511:
510:
506:
504:
501:
498:
494:
490:
489:short stature
485:
483:
479:
475:
472:
468:
464:
445:
441:
437:
433:
430:
427:
423:
422:orally-active
418:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
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295:
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273:
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240:
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177:
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137:
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126:
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105:
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100:
98:
96:
92:
84:
80:
75:
71:
64:
59:
55:
53:
47:
43:
39:
36:Clinical data
34:
30:
25:
1878:expanding it
1867:
1792:Antagonists:
1791:
1776:
1748:Capromorelin
1735:Non-peptide:
1734:
1715:
1646:Alexamorelin
1642:
1639:
1613:Antagonists:
1612:
1562:
1559:
1518:Antagonists:
1517:
1511:Veldoreotide
1397:
1365:
1355:
1341:Antagonists:
1340:
1299:Somatotropin
1240:
1114:Tuberculosis
1046:
1039:
1028:Corticorelin
1020:
977:Pancreozymin
953:Pentagastrin
848:concentrates
726:
722:
712:
679:
675:
669:
644:
640:
607:
572:
568:
540:
536:
526:
486:
419:
394:
390:
382:
374:
370:
366:
362:
358:
350:
349:
82:
78:
1768:Macimorelin
1726:Tabimorelin
1721:Relamorelin
1701:Lenomorelin
1606:Tesamorelin
1601:Somatorelin
1536:Satoreotide
1461:Pasireotide
1446:NNC 26-9100
1426:Ilatreotide
1421:Edotreotide
1359:Atesidorsen
1349:Pegvisomant
1324:Somavaratan
1314:Sometribove
1289:Somapacitan
1284:Somagrebove
1100:Gonadorelin
1082:Thyrotropin
1057:Somatorelin
1047:Pralmorelin
972:Bentiromide
828:Tolbutamide
484:in humans.
482:food intake
457:-Phe-Lys-NH
442:, with the
371:WAY-GPA-748
351:Pralmorelin
277: g·mol
104:158861-67-7
61:Identifiers
41:Other names
21:Pralmorelin
1917:Categories
1743:Anamorelin
1731:Ulimorelin
1706:Livoletide
1696:Ipamorelin
1596:Sermorelin
1591:Rismorelin
1531:CYN-154806
1506:Vapreotide
1456:Octreotide
1451:Octreotate
1441:Lanreotide
1416:Depreotide
1334:Somidobove
1329:Somavubove
1294:Somatosalm
1219:modulators
1157:and other
1122:Tuberculin
1077:Protirelin
1052:Sermorelin
1033:Metyrapone
868:Ceruletide
793:Diagnostic
519:References
282:3D model (
270:Molar mass
189:E6S6E1F19M
160:ChemSpider
140:IUPHAR/BPS
95:CAS Number
70:IUPAC name
1785:LY-444711
1780:LY-426410
1777:Unsorted:
1773:SM-130686
1763:L-692,585
1753:CP-464709
1738:Adenosine
1711:LY-444711
1640:Agonists:
1631:(ghrelin)
1576:Dumorelin
1566:ALRN-5281
1560:Agonists:
1521:BIM-23056
1476:Seglitide
1436:L-817,818
1431:L-803,087
1401:BIM-23052
1398:Agonists:
1344:G120K-hGH
1241:Agonists:
1216:signaling
1140:Alsactide
1012:Pituitary
962:Exocrine
901:Galactose
878:Sincalide
857:Bile duct
846:Vitamin A
719:"Ghrelin"
589:2212-7968
549:0214-0934
543:(1): 33.
426:synthetic
50:Routes of
1938:Peptides
1846:instead.
1795:A-778193
1656:EP-51216
1643:Peptide:
1616:MZ-5-156
1571:CJC-1295
1563:Peptide:
1309:Somatrem
1022:cortisol
1014:function
989:Secretin
929:Caffeine
924:Betazole
883:Sorbitol
815:Diabetes
795:agents (
753:26042199
704:28632234
696:15646371
661:15230633
507:See also
497:phase II
436:analogue
397:), is a
1819:YIL-781
1814:JMV2959
1666:Ghrelin
1496:SRIF-28
1491:SRIF-14
860:patency
823:Glucose
744:4443295
467:agonist
465:(GHSR)
429:peptide
417:(GHD).
367:GPA-748
275:817.992
237:Formula
169:5293451
129:6852372
115:PubChem
1691:GHRP-6
1686:GHRP-5
1681:GHRP-4
1676:GHRP-3
1671:GHRP-1
1501:TT-232
1471:RC-160
1406:CH-275
1155:Inulin
751:
741:
702:
694:
659:
615:
587:
547:
478:hunger
471:plasma
395:GHRP-2
381:) and
363:KP-102
308:SMILES
1868:This
1830:IGF-1
1211:IGF-1
700:S2CID
449:-Ala-
411:Japan
328:InChI
284:JSmol
1874:stub
1844:here
1842:See
1581:GHRH
1547:GHRH
1385:GHIH
1370:GHBP
1213:axis
931:and
749:PMID
692:PMID
657:PMID
613:ISBN
585:ISSN
545:ISSN
432:drug
387:USAN
180:UNII
149:1092
1627:GHS
797:V04
739:PMC
731:doi
684:doi
649:doi
577:doi
438:of
409:in
379:JAN
355:INN
205:EPA
119:CID
1919::
1775:;
1733:;
1228:GH
1207:GH
1041:GH
747:.
737:.
725:.
721:.
698:.
690:.
680:54
678:.
655:.
643:.
627:^
597:^
583:.
571:.
557:^
541:19
539:.
535:.
424:,
369:,
365:,
251:55
245:45
77:(2
1905:e
1898:t
1891:v
1880:.
1807:D
1805:(
1209:/
1198:e
1191:t
1184:v
799:)
785:e
778:t
771:v
755:.
733::
727:4
706:.
686::
663:.
651::
645:5
621:.
591:.
579::
573:7
551:.
491:(
459:2
455:D
451:D
447:D
393:(
385:(
377:(
353:(
286:)
263:6
260:O
257:9
254:N
248:H
242:C
207:)
203:(
83:H
79:S
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