Knowledge (XXG)

Selective reduction

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These trends led to more women asking for reduction to one fetus. These requests increasingly came from women pregnant with twins due to advances in the field of ART which made massively multiple pregnancies rarer. Selective reduction of twins was very controversial at first but has gradually become more accepted. One of the authors of the 1988 guidelines updated his stance and expressed a desire for the procedure to become more available in 2014.
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Over time, more and more women in the developed world sought to become pregnant when they were older, having the first child when they were over forty years old. At the same time, the number of obstetrician-gynecologists with the required expertise increased and their role in family planning evolved.
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It appears that reduction of triplets, where each triplet is in its own placenta, to twins results in a lower risk of preterm birth and does not increase the risk of miscarriage. In triplets where two of the fetuses share a placenta and each has its own amniotic sac, it appears, with less certainty,
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While the data is weak, due to the small sizes of studies and the lack of randomized controlled trials, as of 2017 it appeared that when short term perinatal outcomes in multiple pregnancies reduced to twins are compared to those of non-reduced triplets, there were fewer deaths among the babies born
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triplets, a very rare condition where the triplets share a single placenta, seen on ultrasound. Because a single placenta has difficulty supporting multiple fetuses, in such cases a selective reduction to improve the likelihood of survival for the remaining fetus or fetuses may be
136:. The result is a reduction in the number of fetuses to a number that is more safe for the mother and the remaining fetuses or more compatible with socio-economic constraints on the caregivers. It is also used in cases of multiple pregnancy where at least one of the fetuses is 82:; outcomes for both the mother and the babies are generally worse the higher the number of fetuses. The procedure is also used in multiple pregnancies when one of the fetuses has a serious and incurable disease, or in the case where one of the fetuses is 144:
syndrome, where one fetus lacks a heart; the second twin, termed a "pump" twin therefore supplies the second twin with blood, leading to heart failure and death in the second twin in 50-75% of cases if the acardiac twin is not terminated.
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The reduction procedure is generally carried out during the first trimester of pregnancy. The procedure often takes two days; the first day is for testing, and the procedure happens on the second day. The fetuses are evaluated, first by
124:. On the left, an acardiac twin which lacks both a heart and head. On the right, the "pump twin" which supplies the acardiac twin with blood. A selective termination of the acardiac twin reduces the risk of death of the pump twin. 42: 41: 43: 219:(ART) became aware of the risks that multiple pregnancies carried for the mother and for the fetuses. The procedure was somewhat controversial from the beginning and drew some attention from anti-abortion activists. 206:
is injected into the heart of each selected fetus under the guidance of ultrasound imaging; the heart stops and the fetus dies as a result. Generally, the fetal material is reabsorbed into the woman's body.
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Selective reduction was developed in the mid-1980s, as people in the field of assisted reproductive technology became aware of the risks that multiple pregnancies carried for the mother and for the fetuses.
40: 351: 864: 299:"Risks of miscarriage or preterm delivery in trichorionic and dichorionic triplet pregnancies with embryo reduction versus expectant management: a systematic review and meta-analysis" 1219: 97:
is injected into the heart of each selected fetus under the guidance of ultrasound imaging. Risks of the procedure include bleeding requiring transfusion, rupture of the uterus,
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Zipori, Y; Haas, J; Berger, H; Barzilay, E (September 2017). "Multifetal pregnancy reduction of triplets to twins compared with non-reduced triplets: a meta-analysis".
500: 78:. The procedure is most commonly done to reduce the number of fetuses in a multiple pregnancy to a safe number, when the multiple pregnancy is the result of use of 2221: 857: 355: 153:, and had higher birthweight. As of 2017, longterm outcomes were not well understood. A 2015 Cochrane review found no randomized clinical trials to evaluate. 1321: 140:
to preserve the life of the mother and the fetus in the uterus, and when one or more of the fetuses has a serious and incurable disease. One example of is
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The procedure generally takes two days; the first day for testing to select which fetuses to reduce, and the 2nd day for the procedure itself, in which
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Generally selective reduction reduces the risk of preterm birth, leading to better outcomes for both mothers and the newborns.
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and was published in 1988; it justified reducing pregnancies with more than three fetuses to two or three.
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Selective reduction is used when a mother is carrying an unsafe or undesirable number of fetuses in a
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ObiÄŤan, S; Brock, C; Berkowitz, R; Wapner, RJ (September 2015). "Multifetal Pregnancy Reduction".
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Legendre, Claire-Marie; Moutel, Grégoire; Drouin, Régen; Favre, Romain; Bouffard, Chantal (2013).
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that there is also a lower risk of preterm birth and no increase in the risk of miscarriage.
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to mothers who underwent reduction, the twins were born later and were less likely to be
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A set of ethical guidelines was developed in collaboration with a bioethicist from the
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Risks of the procedure include bleeding requiring transfusion, rupture of the uterus,
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Evans, MI; Fletcher, JC; Zador, IE; Newton, BW; Quigg, MH; Struyk, CD (March 1988).
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is widely considered to be unethical in making decisions about which fetus to keep.
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Selective reduction was developed in the mid-1980s, as people in the field of
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Anthoulakis, C; Dagklis, T; Mamopoulos, A; Athanasiadis, A (1 June 2017).
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Abortion of one or more (but not all) fetuses in a multiple pregnancy
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Beriwal, Sridevi; Impey, Lawrence; Ioannou, Christos (Oct 2020).
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Dodd, JM; Dowswell, T; Crowther, CA (4 November 2015).
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or singleton pregnancy. The procedure is also called
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Each of these appears to be rare. 1516:Societal attitudes towards abortion 1436:Legalized abortion and crime effect 834:Gaither, Kecia (January 30, 2018). 264:"UOTW #19 - Ultrasound of the Week" 1466:Misinformation related to abortion 1376:Beginning of pregnancy controversy 751:Clinical Obstetrics and Gynecology 25: 1381:Abortion-breast cancer hypothesis 1048:Preimplantation genetic diagnosis 531:Padawer, Ruth (August 10, 2011). 2602:Assisted reproductive technology 2571: 2570: 1028:Intracytoplasmic sperm injection 1003:Autologous endometrial coculture 874:Assisted reproductive technology 815: 734: 582: 481: 418: 217:assisted reproductive technology 177:, infection, a miscarriage, and 101:, infection, a miscarriage, and 80:assisted reproductive technology 1526:Termination for medical reasons 557:Reproductive Biomedicine Online 391:Reproductive BioMedicine Online 274:from the original on 9 May 2017 18:Pregnancy reduction, multifetal 1111:Gamete intrafallopian transfer 1058:Zygote intrafallopian transfer 703:10.1002/14651858.CD003932.pub3 134:medically assisted pregnancies 76:multifetal pregnancy reduction 1: 1371:Beginning of human personhood 1215:Genetic diagnosis of intersex 1043:Partner-assisted reproduction 533:"The Two-Minus-One Pregnancy" 224:National Institute for Health 179:prelabor rupture of membranes 103:prelabor rupture of membranes 86:, in which case it is called 29:Selective catalytic reduction 1481:Paternal rights and abortion 763:10.1097/GRF.0000000000000119 615:10.1097/AOG.0b013e3182736b09 499:Mundy, Liza (May 20, 2007). 138:implanted outside the uterus 1406:Ethical aspects of abortion 1053:Transvaginal ovum retrieval 446:Fetal Diagnosis and Therapy 2618: 1366:Abortion and mental health 609:(2 Pt 2 Suppl 1): 489–95. 569:10.1016/j.rbmo.2017.05.012 404:10.1016/j.rbmo.2013.02.004 196:testing the amniotic fluid 26: 2566: 1345:Abortion-rights movements 1220:Religious response to ART 798:Obstetrics and Gynecology 603:Obstetrics and Gynecology 200:chorionic villus sampling 1606:Central African Republic 1391:Abortion under communism 1038:Ovarian hyperstimulation 505:Washington Post Magazine 27:Not to be confused with 2441:Dilation and evacuation 2390:Conscientious objection 2375:History of abortion law 1401:Crisis pregnancy center 1350:Anti-abortion movements 1074:Artificial insemination 920:Male infertility crisis 537:New York Times Magazine 232:Sex-selective reduction 2446:Dilation and curettage 2410:Late-term restrictions 1930:Bosnia and Herzegovina 1506:Sex-selective abortion 1386:Anti-abortion violence 1225:Mitochondrial donation 1159:Donor Sibling Registry 998:Assisted zona hatching 987:In vitro fertilisation 268:Ultrasound of the Week 132:, which are common in 125: 52: 2503:Self-induced abortion 1501:Self-induced abortion 1426:Genetics and abortion 1322:Philosophical aspects 316:10.1093/humrep/dex084 270:. 23 September 2014. 120: 88:selective termination 46: 2466:Menstrual extraction 2415:Parental involvement 1877:United Arab Emirates 1491:Prenatal development 1116:Reproductive surgery 1008:Cytoplasmic transfer 938:Estrogen antagonists 930:Fertility medication 501:"Too Much to Carry?" 244:McCaughey septuplets 2476:Abortifacient drugs 2196:Trinidad and Tobago 1511:Sidewalk counseling 1496:Reproductive rights 1461:Minors and abortion 1128:Selective reduction 1079:Ovulation induction 1023:In vitro maturation 1018:Gestational carrier 943:aromatase inhibitor 56:Selective reduction 2370:Constitutional law 2161:Dominican Republic 1486:Post-abortion care 1446:Limit of viability 1431:Late-term abortion 1154:Donor registration 1121:Vasectomy reversal 804:(3 Pt 1): 289–96. 204:potassium chloride 130:multiple pregnancy 126: 95:potassium chloride 84:outside the uterus 64:multiple pregnancy 53: 2584: 2583: 2436:Vacuum aspiration 2351: 2350: 1254: 1253: 1205:Accidental incest 915:Fertility tourism 910:Fertility testing 663:10.1111/tog.12690 511:on April 5, 2015. 459:10.1159/000357974 175:retained placenta 99:retained placenta 44: 16:(Redirected from 2609: 2574: 2573: 2471:Medical abortion 2405:Informed consent 2395:Fetal protection 2247:Papua New Guinea 2237:Marshall Islands 1554: 1476:One-child policy 1281: 1274: 1267: 1258: 1179:Semen collection 1084:Cryopreservation 1033:Oocyte selection 905:Fertility clinic 867: 860: 853: 844: 839: 821: 820: 819: 813: 789: 783: 782: 746: 740: 739: 738: 732: 714: 697:(11): CD003932. 682: 676: 675: 665: 641: 635: 634: 594: 588: 587: 586: 580: 552: 541: 540: 528: 513: 512: 507:. 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1289: 1282: 1277: 1275: 1270: 1268: 1263: 1262: 1259: 1247: 1244: 1243: 1241: 1237: 1231: 1230:Sex selection 1228: 1226: 1223: 1221: 1218: 1216: 1213: 1211: 1208: 1206: 1203: 1202: 1200: 1196: 1190: 1187: 1185: 1182: 1180: 1177: 1175: 1172: 1170: 1167: 1165: 1162: 1160: 1157: 1155: 1152: 1151: 1149: 1145: 1139: 1136: 1134: 1133:Sex selection 1131: 1129: 1126: 1122: 1119: 1118: 1117: 1114: 1112: 1109: 1105: 1102: 1100: 1097: 1095: 1092: 1090: 1087: 1086: 1085: 1082: 1080: 1077: 1075: 1072: 1071: 1069: 1067:Other methods 1065: 1059: 1056: 1054: 1051: 1049: 1046: 1044: 1041: 1039: 1036: 1034: 1031: 1029: 1026: 1024: 1021: 1019: 1016: 1014: 1011: 1009: 1006: 1004: 1001: 999: 996: 995: 993: 988: 984: 978: 975: 971: 968: 967: 966: 965:Gonadotropins 963: 961: 960:GnRH agonists 958: 956: 953: 949: 946: 944: 941: 940: 939: 936: 935: 933: 931: 927: 921: 918: 916: 913: 911: 908: 906: 903: 901: 898: 896: 893: 891: 888: 887: 885: 883: 879: 875: 868: 863: 861: 856: 854: 849: 848: 845: 837: 832: 831: 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2486:Mifepristone 2481:Methotrexate 2461:Instillation 2385:Buffer zones 1857:Saudi Arabia 1686:South Africa 1681:Sierra Leone 1586:Burkina Faso 1456:Men's rights 1416:Fetal rights 1329:Abortion law 1164:Egg donation 1127: 801: 797: 787: 754: 750: 744: 694: 690: 680: 653: 649: 639: 606: 602: 592: 560: 556: 536: 509:the original 504: 452:(2): 69–82. 449: 445: 394: 390: 360:. 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WebMD. 779:10307261 771:26083128 729:38648757 721:26544079 631:40913509 623:23344419 577:28625760 468:24525884 413:23518032 325:28444191 272:Archived 238:See also 157:Outcomes 2553:Judaism 2429:Methods 2338:Uruguay 2313:Ecuador 2293:Bolivia 2272:Vanuatu 2210:Oceania 2136:Bahamas 2115:Ukraine 2070:Romania 2030:Moldova 1990:Ireland 1985:Iceland 1980:Hungary 1970:Germany 1960:Finland 1955:Estonia 1950:Denmark 1940:Croatia 1925:Belgium 1920:Belarus 1915:Austria 1910:Andorra 1905:Albania 1882:Vietnam 1827:Lebanon 1782:Georgia 1742:Bahrain 1732:Armenia 1676:Senegal 1671:Nigeria 1666:Namibia 1651:Liberia 1646:Lesotho 1591:Burundi 1566:Algeria 1312:Methods 1307:History 1239:Related 1089:embryos 810:3347412 712:7104508 476:5136936 333:3778609 211:History 70:, to a 60:fetuses 2318:Guyana 2298:Brazil 2267:Tuvalu 2191:Panama 2181:Mexico 2146:Canada 2141:Belize 2105:Sweden 2085:Serbia 2075:Russia 2060:Poland 2055:Norway 2035:Monaco 2005:Latvia 1975:Greece 1965:France 1897:Europe 1872:Turkey 1867:Taiwan 1797:Israel 1772:Cyprus 1757:Brunei 1752:Bhutan 1706:Zambia 1701:Uganda 1661:Malawi 1636:Guinea 1571:Angola 1558:Africa 1359:Issues 1198:Ethics 1169:Embryo 1094:oocyte 890:Female 808:  777:  769:  727:  719:  709:  670:  629:  621:  575:  474:  466:  411:  331:  323:  278:27 May 2548:Islam 2303:Chile 2262:Tonga 2252:Samoa 2100:Spain 2025:Malta 1995:Italy 1887:Yemen 1852:Qatar 1837:Nepal 1802:Japan 1787:India 1767:China 1641:Kenya 1631:Ghana 1616:Egypt 1576:Benin 1174:Sperm 1104:semen 989:(IVF) 775:S2CID 725:S2CID 627:S2CID 472:S2CID 329:S2CID 62:in a 2328:Peru 2227:Fiji 2156:Cuba 1822:Laos 1792:Iran 1720:Asia 1696:Togo 1611:Chad 900:LGBT 895:Male 806:PMID 767:PMID 717:PMID 668:ISSN 619:PMID 573:PMID 464:PMID 409:PMID 321:PMID 280:2017 198:and 142:TRAP 72:twin 2357:Law 977:hCG 955:FSH 759:doi 707:PMC 699:doi 658:doi 611:doi 607:121 565:doi 454:doi 399:doi 311:doi 2593:: 802:71 800:. 796:. 773:. 765:. 755:58 753:. 723:. 715:. 705:. 695:11 693:. 689:. 666:. 654:22 652:. 648:. 625:. 617:. 605:. 601:. 571:. 561:35 559:. 545:^ 535:. 517:^ 503:. 491:^ 470:. 462:. 450:35 448:. 444:. 428:^ 407:. 395:26 393:. 389:. 371:^ 341:^ 327:. 319:. 307:32 305:. 301:. 289:^ 266:. 90:. 1280:e 1273:t 1266:v 866:e 859:t 852:v 812:. 781:. 761:: 731:. 701:: 674:. 660:: 633:. 613:: 579:. 567:: 539:. 478:. 456:: 415:. 401:: 365:. 335:. 313:: 282:. 31:. 20:)

Index

Pregnancy reduction, multifetal
Selective catalytic reduction
Monoamniotic
fetuses
multiple pregnancy
quadruplets
twin
assisted reproductive technology
outside the uterus
potassium chloride
retained placenta
prelabor rupture of membranes

TRAP syndrome
multiple pregnancy
medically assisted pregnancies
implanted outside the uterus
TRAP
premature
retained placenta
prelabor rupture of membranes
ultrasound
testing the amniotic fluid
chorionic villus sampling
potassium chloride
assisted reproductive technology
National Institute for Health
Sex-selective reduction
McCaughey septuplets
"UOTW #19 - Ultrasound of the Week"

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