Knowledge (XXG)

Lansoprazole

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and was given the development name AG 1749. Takeda patented it in 1984 and the drug launched in 1991. In the United States, it was approved for medical use in 1995.
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Hirschowitz BI, Mohnen J, Shaw S (August 1996). "Long-term treatment with lansoprazole for patients with Zollinger-Ellison syndrome".
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Villemagne VL, Fodero-Tavoletti MT, Masters CL, Rowe CC (January 2015). "Tau imaging: early progress and future directions".
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Salloum A, Nasr D, Maalouf D (April 2021). "Dermatologic adverse reactions to proton-pump inhibitors: A synthetized review".
1610: 1556:. Dept of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia. 28 June 2016 1262:
and levolansoprazole. Dexlansoprazole is an enantiomerically pure active ingredient of a commercial drug as a result of the
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InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
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causing ulcers or other problems involves using two other drugs besides lansoprazole known as "
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Piscitelli SC, Goss TF, Wilton JH, D'Andrea DT, Goldstein H, Schentag JJ (September 1991).
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Lansoprazole interacts with several other drugs, either due to its own nature or as a PPI.
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Lansoprazole was patented in 1984 and came into medical use in 1992. It is available as a
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Patent protection of the lansoprazole molecule expired on 10 November 2009, and
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Side effects of PPIs in general and lansoprazole in particular may include:
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Sterry W, Assaf C (2007). "Erythroderma". In Bolognia JL (ed.).
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became available under many brand names in many countries. Some
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PPIs may be associated with a greater risk of hip fractures and
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There is no good evidence that it works better than other PPIs.
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Lansoprazole possibly interacts with, among other drugs:
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Drug Discovery and Development, Volume 1: Drug Discovery
2185:"Prevacid 24 HR- lansoprazole capsule, delayed release" 2159:"Prevacid 24 HR- lansoprazole capsule, delayed release" 841: 2091:"Teva to release Prevacid version when patent expires" 2740: 2217:. U.S. National Library of Medicine. 21 December 2017 2191:. U.S. National Library of Medicine. 11 December 2019 1550:"Comparative effectiveness of proton pump inhibitors" 113: 98: 83: 77: 1463:. U.S. National Library of Medicine. 11 October 2016 1451: 1449: 1447: 1445: 1443: 1441: 104: 92: 89: 71: 2651: 2540: 2504: 2434: 2405: 2352: 1282:
Discovery and development of proton pump inhibitors
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It works by blocking 2327: 2313: 2305: 1659:Alimentary Pharmacology & Therapeutics 1494:"Lansoprazole Monograph for Professionals" 1488: 1486: 1484: 1482: 1480: 1478: 1386: 1384: 982:(adjunctive treatment), treatment to kill 680: 657: 546: 1915: 566: 1544: 1542: 1523:British national formulary : BNF 76 1064:, hypersensitivity reactions (including 2747: 1517: 1515: 1380: 955:Lansoprazole is used for treatment of: 821: 804:FC(F)(F)COc1ccnc(c1C)CS(=O)c2c3ccccc3n2 801: 653: 526: 437: 167: 2024:. John Wiley & Sons. p. 201. 1997:. John Wiley & Sons. p. 102. 1633:"Lansoprazole - Drug Usage Statistics" 1581:. John Wiley & Sons. p. 445. 1319:may not be available in generic form. 788:178 °C (352 °F) (decomposes) 671: 31: 2674:Vonoprazan/amoxicillin/clarithromycin 1896:Antimicrobial Agents and Chemotherapy 626: 606: 153: 7: 1613:from the original on 15 January 2024 274: 1671:10.1046/j.1365-2036.1996.10152000.x 1392:"Lansoprazole Use During Pregnancy" 1181:Increases plasma concentrations of 901:. Serious side effects may include 586: 477: 27:Stomach acid suppressing medication 1968:. RxList.com. 2007. Archived from 25: 1836:. St. Louis: Mosby. p. 154. 2750: 2664:Omeprazole/amoxicillin/rifabutin 1023:Common: diarrhea, abdominal pain 717: 711: 705: 67: 49: 40: 2089:Witkowski W (7 November 2008). 1991:Fischer J, Ganellin CR (2006). 1791:Journal of Cosmetic Dermatology 1575:Fischer J, Ganellin CR (2006). 1001:Gastroesophageal reflux disease 876:gastroesophageal reflux disease 829:Key:MJIHNNLFOKEZEW-UHFFFAOYSA-N 1701:"1.3.5 Proton pump inhibitors" 729: 723: 699: 1: 2279:10.1016/s1474-4422(14)70252-2 1994:Analogue-based Drug Discovery 1578:Analogue-based Drug Discovery 1096:, blood disorders (including 1120:, skin reactions including ( 889:Common side effects include 854:, sold under the brand name 2783:Drugs developed by Novartis 1859:"Lansoprazole interactions" 2844: 2778:Drugs developed by GSK plc 1863:British National Formulary 1737:British National Formulary 1705:British National Formulary 1279: 1162:PPIs reduce absorption of 1130:toxic epidermal necrolysis 1006:Zollinger–Ellison syndrome 880:Zollinger–Ellison syndrome 689:Chemical and physical data 2828:Trifluoromethyl compounds 2818:Drugs developed by AbbVie 2701: 2682: 1940:"Pharmacy Benefit Update" 1174:) and possibly increase 837: 812: 792: 428: 48: 39: 1126:Stevens–Johnson syndrome 1052:Rarely and very rarely: 2382:Lavoltidine (loxtidine) 2068:"Prevacid Drug Profile" 1554:Therapeutics Initiative 947:million prescriptions. 2798:Proton-pump inhibitors 2669:Vonoprazan/amoxicillin 2506:Potassium-competitive 2436:Proton-pump inhibitors 2134:"Generic lansoprazole" 1303: 1094:interstitial nephritis 306: S2, S3, & S4 2692:eradication protocols 2548:Aceglutamide aluminum 2267:The Lancet. Neurology 2070:. Drugpatentwatch.com 2018:Chorghade MS (2006). 1908:10.1128/aac.35.9.1765 1603:"The Top 300 of 2021" 1301: 1143:Clostridium difficile 978:infection, alongside 912:Clostridium difficile 870:(PPI), used to treat 868:proton pump inhibitor 440:2-{methanesulfinyl}-1 256:Proton pump inhibitor 2563:Arbaclofen placarbil 2050:Mosby's Drug Consult 1313:generic formulations 872:peptic ulcer disease 2690:Helicobacter pylori 2056:on 8 February 2009. 1745:on 21 February 2020 1713:on 21 February 2020 1369:Alzheimer's disease 1350:the pathogenic form 1302:Prevacid 30 mg 1294:Society and culture 1255:1:1 mixture of the 975:Helicobacter pylori 962:of the stomach and 907:low blood magnesium 858:among others, is a 319:(Prescription only) 36: 2728:Never to phase III 2568:Bismuth subcitrate 2243:. 2 September 2019 1803:10.1111/jocd.13763 1304: 1265:enantiomeric shift 1185:(risk of toxicity) 941:generic medication 2738: 2737: 1972:on 16 August 2000 1871:on 28 August 2021 1843:978-1-4160-2999-1 1062:peripheral oedema 849: 848: 761:Interactive image 639:CompTox Dashboard 327: 314: 305: 221: 188: 16:(Redirected from 2835: 2755: 2754: 2753: 2746: 2638:Zinc L-carnosine 2329: 2322: 2315: 2306: 2299: 2298: 2262: 2253: 2252: 2250: 2248: 2241:NPS MedicineWise 2233: 2227: 2226: 2224: 2222: 2207: 2201: 2200: 2198: 2196: 2181: 2175: 2174: 2172: 2170: 2155: 2149: 2148: 2146: 2144: 2130: 2124: 2123: 2121: 2119: 2105: 2099: 2098: 2086: 2080: 2079: 2077: 2075: 2064: 2058: 2057: 2052:. Archived from 2042: 2036: 2035: 2015: 2009: 2008: 1988: 1982: 1981: 1979: 1977: 1962: 1956: 1955: 1953: 1951: 1942:. Archived from 1936: 1930: 1929: 1919: 1902:(9): 1765–1771. 1887: 1881: 1880: 1878: 1876: 1870: 1865:. Archived from 1855: 1849: 1847: 1829: 1823: 1822: 1797:(4): 1073–1079. 1786: 1780: 1779: 1777: 1775: 1761: 1755: 1754: 1752: 1750: 1744: 1739:. Archived from 1729: 1723: 1722: 1720: 1718: 1712: 1707:. Archived from 1697: 1691: 1690: 1654: 1648: 1647: 1645: 1643: 1629: 1623: 1622: 1620: 1618: 1599: 1593: 1592: 1572: 1566: 1565: 1563: 1561: 1546: 1537: 1536: 1519: 1510: 1509: 1507: 1505: 1490: 1473: 1472: 1470: 1468: 1453: 1436: 1435: 1433: 1431: 1421:nctr-crs.fda.gov 1413: 1407: 1406: 1404: 1402: 1388: 1329:over the counter 1134:bullous eruption 1110:thrombocytopenia 1078:photosensitivity 946: 936:of the stomach. 845: 844: 763: 743: 731: 725: 719: 713: 707: 701: 684: 673: 662: 661: 647: 645: 630: 610: 590: 570: 550: 530: 510: 490: 480: 479: 465: 399: 337: 332: 325: 322: 312: 309: 303: 300: 278: 219: 216: 198: 187: 184: 171: 157: 131:Prevacid, others 117: 111: 110: 107: 106: 103: 100: 97: 94: 91: 88: 85: 82: 79: 76: 73: 53: 44: 37: 35: 21: 2843: 2842: 2838: 2837: 2836: 2834: 2833: 2832: 2788:Organofluorides 2763: 2762: 2761: 2751: 2749: 2741: 2739: 2734: 2733: 2718:Clinical trials 2697: 2678: 2647: 2536: 2507: 2500: 2451:Dexlansoprazole 2438: 2430: 2410: 2401: 2357: 2348: 2333: 2303: 2302: 2264: 2263: 2256: 2246: 2244: 2237:"Zoton FasTabs" 2235: 2234: 2230: 2220: 2218: 2209: 2208: 2204: 2194: 2192: 2183: 2182: 2178: 2168: 2166: 2157: 2156: 2152: 2142: 2140: 2132: 2131: 2127: 2117: 2115: 2107: 2106: 2102: 2088: 2087: 2083: 2073: 2071: 2066: 2065: 2061: 2044: 2043: 2039: 2032: 2017: 2016: 2012: 2005: 1990: 1989: 1985: 1975: 1973: 1964: 1963: 1959: 1949: 1947: 1946:on 14 July 2014 1938: 1937: 1933: 1889: 1888: 1884: 1874: 1872: 1857: 1856: 1852: 1844: 1831: 1830: 1826: 1788: 1787: 1783: 1773: 1771: 1763: 1762: 1758: 1748: 1746: 1731: 1730: 1726: 1716: 1714: 1699: 1698: 1694: 1656: 1655: 1651: 1641: 1639: 1631: 1630: 1626: 1616: 1614: 1601: 1600: 1596: 1589: 1574: 1573: 1569: 1559: 1557: 1548: 1547: 1540: 1533: 1521: 1520: 1513: 1503: 1501: 1492: 1491: 1476: 1466: 1464: 1455: 1454: 1439: 1429: 1427: 1415: 1414: 1410: 1400: 1398: 1390: 1389: 1382: 1377: 1363:for diagnosing 1341: 1325: 1309: 1296: 1284: 1278: 1260:dexlansoprazole 1249: 1156: 1017: 970:-induced ulcers 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2402: 2400: 2399: 2394: 2389: 2384: 2379: 2374: 2369: 2363: 2361: 2355: 2350: 2349: 2334: 2332: 2331: 2324: 2317: 2309: 2301: 2300: 2273:(1): 114–124. 2254: 2228: 2202: 2176: 2150: 2125: 2100: 2081: 2059: 2046:"Lansoprazole" 2037: 2030: 2010: 2003: 1983: 1957: 1931: 1882: 1850: 1842: 1824: 1781: 1756: 1733:"Lansoprazole" 1724: 1692: 1665:(4): 507–522. 1649: 1624: 1594: 1587: 1567: 1538: 1531: 1511: 1474: 1437: 1408: 1379: 1378: 1376: 1373: 1340: 1337: 1324: 1321: 1308: 1305: 1295: 1292: 1280:Main article: 1277: 1274: 1272:suppression). 1248: 1245: 1244: 1243: 1238: 1229: 1224: 1221: 1216: 1211: 1206: 1201: 1196: 1187: 1186: 1179: 1155: 1152: 1138: 1137: 1050: 1024: 1016: 1013: 1009: 1008: 1003: 998: 996:clarithromycin 988:triple therapy 971: 952: 949: 934:parietal cells 895:abdominal pain 862:which reduces 847: 846: 835: 834: 832: 831: 828: 826: 823: 815: 814: 813: 810: 809: 807: 806: 803: 795: 794: 793: 790: 789: 786: 780: 779: 774: 768: 767: 765: 764: 756: 754: 746: 745: 739: 733: 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877: 873: 869: 865: 861: 857: 853: 843: 836: 827: 822: 818: 811: 802: 798: 791: 787: 785: 784:Melting point 781: 778: 775: 773: 769: 762: 758: 757: 755: 752: 747: 740: 738: 734: 698: 696: 692: 687: 683: 679: 676: 674: 672:ECHA InfoCard 668: 660: 656: 655:DTXSID4023200 652: 651: 649: 640: 636: 629: 625: 624: 622: 620: 616: 609: 605: 604: 602: 600: 596: 589: 585: 584: 582: 580: 576: 569: 565: 564: 562: 560: 556: 549: 545: 544: 542: 540: 536: 529: 525: 524: 522: 520: 516: 509: 505: 504: 502: 500: 496: 489: 485: 484: 482: 475: 471: 464: 460: 459: 457: 455: 451: 443: 438: 434: 427: 422: 419: 415: 412: 410: 406: 403:1.0–1.5 hours 402: 400: 393: 389: 385: 381: 378: 376: 372: 368: 366: 362: 358: 356: 352: 348: 344: 333: 321: 318: 308: 299: 298: 296: 294: 290: 285: 277: 272: 269: 268: 266: 264: 260: 257: 254: 252: 248: 245: 241: 238: 236: 230: 224: 215: 214: 212: 210: 204: 197: 192: 183: 182: 180: 178: 174: 170: 166: 164: 160: 156: 152: 150: 146: 142: 138: 134: 130: 128: 124: 120: 119: 109: 65: 63:Pronunciation 61: 58:Clinical data 56: 52: 47: 43: 38: 30: 19: 2689: 2686: 2652:Combinations 2618:Sulglicotide 2558:Alginic acid 2476:Pantoprazole 2466:Lansoprazole 2465: 2456:Esomeprazole 2446:Azeloprazole 2439:("-prazole") 2337:peptic ulcer 2270: 2266: 2245:. Retrieved 2240: 2231: 2219:. Retrieved 2214: 2205: 2193:. Retrieved 2188: 2179: 2167:. Retrieved 2162: 2153: 2141:. Retrieved 2137: 2128: 2116:. Retrieved 2112: 2103: 2097:. Dow Jones. 2095:Market Watch 2094: 2084: 2072:. Retrieved 2062: 2054:the original 2049: 2040: 2020: 2013: 1993: 1986: 1974:. Retrieved 1970:the original 1960: 1948:. Retrieved 1944:the original 1934: 1899: 1895: 1885: 1873:. Retrieved 1868:the original 1862: 1853: 1833: 1827: 1794: 1790: 1784: 1772:. Retrieved 1768: 1759: 1747:. Retrieved 1742:the original 1736: 1727: 1715:. Retrieved 1710:the original 1704: 1695: 1662: 1658: 1652: 1640:. Retrieved 1636: 1627: 1615:. Retrieved 1606: 1597: 1577: 1570: 1558:. Retrieved 1553: 1522: 1502:. Retrieved 1497: 1465:. Retrieved 1460: 1428:. Retrieved 1420: 1411: 1399:. Retrieved 1395: 1343: 1342: 1326: 1323:Availability 1317:formulations 1310: 1285: 1270:gastric acid 1263: 1250: 1236:theophylline 1227:voriconazole 1188: 1172:ketoconazole 1168:itraconazole 1157: 1154:Interactions 1146:-associated 1141: 1139: 1122:erythroderma 1106:pancytopenia 1102:leukocytosis 1066:bronchospasm 1026:Infrequent: 1018: 1015:Side effects 1010: 983: 973: 954: 951:Medical uses 938: 911: 903:osteoporosis 891:constipation 888: 864:stomach acid 855: 852:Lansoprazole 851: 850: 839:   441: 396:Elimination 293:Legal status 287:Legal status 196:Lansoprazole 177:License data 34:Lansoprazole 29: 2714:from market 2623:Telenzepine 2598:Pirenzepine 2593:Lesogaberan 2588:Irsogladine 2553:Acetoxolone 2510:("-prazan") 2496:Timoprazole 2486:Rabeprazole 2481:Picoprazole 2421:Misoprostol 2414:("-prost-") 2360:("-tidine") 2358:antagonists 2221:31 December 2195:31 December 2169:31 December 2143:20 November 1834:Dermatology 1467:31 December 1365:tauopathies 1358:PET imaging 1354:tau protein 1257:enantiomers 1219:fluvoxamine 1214:delavirdine 1209:clopidogrel 1164:antifungals 1074:anaphylaxis 1068:, urinary, 992:amoxicillin 980:antibiotics 744: g·mol 678:100.173.220 463:103577-45-3 424:Identifiers 359:80% or more 244:intravenous 163:MedlinePlus 136:Other names 127:Trade names 2813:Sulfoxides 2767:Categories 2687:See also: 2643:Zolimidine 2613:Sucralfate 2608:Rebamipide 2603:Proglumide 2532:Vonoprazan 2527:Soraprazan 2522:Revaprazan 2517:Linaprazan 2471:Omeprazole 2461:Ilaprazole 2397:Roxatidine 2392:Ranitidine 2387:Nizatidine 2377:Lafutidine 2372:Famotidine 2367:Cimetidine 2335:Drugs for 2118:3 February 1875:1 February 1774:9 February 1749:1 February 1717:1 February 1642:14 January 1617:14 January 1430:22 October 1375:References 1367:including 1335:as Zoton. 1241:astemizole 1223:iron salts 1199:ampicillin 1194:sucralfate 1183:cilostazol 1114:arthralgia 1098:leukopenia 1090:depression 1070:angioedema 1038:, blurred 1036:drowsiness 930:H/K-ATPase 866:. It is a 860:medication 749:3D model ( 737:Molar mass 608:CHEBI:6375 568:0K5C5T2QPG 539:ChemSpider 499:IUPHAR/BPS 454:CAS Number 433:IUPAC name 390:-mediated) 375:Metabolism 334:OTC / 251:Drug class 2803:Pyridines 2724:Phase III 2712:Withdrawn 2633:Troxipide 2628:Teprenone 2583:Gefarnate 2578:Cetraxate 2426:Enprostil 2412:analogues 2341:GERD/GORD 2138:Drugs.com 2113:Drugs.com 1819:222236157 1498:Drugs.com 1396:Drugs.com 1247:Chemistry 1204:bisacodyl 1178:in plasma 1028:dry mouth 984:H. pylori 922:pregnancy 920:. Use in 918:pneumonia 914:infection 772:Chirality 628:ChEMBL480 409:Excretion 398:half-life 233:Routes of 207:Pregnancy 155:Monograph 149:Drugs.com 118:-prə-zohl 2757:Medicine 2295:10502833 2287:25496902 2247:24 April 2215:DailyMed 2189:DailyMed 2163:DailyMed 2074:30 April 1976:14 April 1811:33031621 1687:10668517 1637:ClinCalc 1611:Archived 1607:ClinCalc 1461:DailyMed 1345:In vitro 1339:Research 1251:It is a 1148:diarrhea 1086:sweating 1048:pruritus 1032:insomnia 964:duodenum 884:by mouth 856:Prevacid 842:(verify) 519:DrugBank 263:ATC code 240:By mouth 222: B3 209:category 191:DailyMed 18:Prevacid 1926:1952845 1679:8853754 1560:14 July 1504:3 March 1401:3 March 1307:Patents 1276:History 1253:racemic 1176:digoxin 1118:myalgia 932:in the 695:Formula 528:DB00448 474:PubChem 388:CYP2C19 338:Rx-only 331:WARNING 279:) 273: ( 271:A02BC03 193::  169:a695020 139:AG 1749 2808:Sanofi 2743:Portal 2707:WHO-EM 2541:Others 2293:  2285:  2028:  2001:  1950:2 July 1924:  1917:245265 1914:  1840:  1817:  1809:  1769:RxList 1685:  1677:  1585:  1529:  1361:agents 1333:Pfizer 1288:Takeda 1040:vision 994:, and 966:, and 960:Ulcers 945:  916:, and 899:nausea 897:, and 878:, and 797:SMILES 742:369.36 619:ChEMBL 588:D00355 414:Kidney 386:- and 384:CYP3A4 336:  328: 315: 189:  121: 2291:S2CID 1815:S2CID 1683:S2CID 1082:fever 1058:liver 1054:taste 968:NSAID 817:InChI 751:JSmol 599:ChEBI 418:fecal 380:Liver 2409:(E)/ 2345:A02B 2339:and 2283:PMID 2249:2022 2223:2019 2197:2019 2171:2019 2145:2023 2120:2015 2076:2020 2026:ISBN 1999:ISBN 1978:2007 1952:2014 1922:PMID 1877:2012 1838:ISBN 1807:PMID 1776:2016 1751:2012 1719:2012 1675:PMID 1644:2024 1619:2024 1583:ISBN 1562:2016 1527:ISBN 1506:2019 1469:2019 1432:2023 1403:2019 1234:and 1170:and 1044:rash 924:and 579:KEGG 559:UNII 548:3746 508:7208 488:3883 416:and 349:data 145:AHFS 114:lan- 2275:doi 1912:PMC 1904:doi 1799:doi 1667:doi 1425:FDA 1352:of 1112:), 1076:), 644:EPA 478:CID 369:97% 317:POM 276:WHO 116:SOH 2769:: 2720:: 2289:. 2281:. 2271:14 2269:. 2257:^ 2239:. 2213:. 2187:. 2161:. 2136:. 2111:. 2093:. 2048:. 1920:. 1910:. 1900:35 1898:. 1894:. 1861:. 1813:. 1805:. 1795:20 1793:. 1767:. 1735:. 1703:. 1681:. 1673:. 1663:10 1661:. 1635:. 1609:. 1605:. 1552:. 1541:^ 1514:^ 1496:. 1477:^ 1459:. 1440:^ 1423:. 1419:. 1394:. 1383:^ 1371:. 1150:. 1132:, 1128:, 1124:, 1116:, 1108:, 1104:, 1100:, 1092:, 1088:, 1084:, 1080:, 1072:, 1046:, 1042:, 1034:, 1030:, 909:, 905:, 893:, 874:, 709:14 703:16 324:US 311:UK 302:AU 242:, 218:AU 186:US 102:oʊ 87:oʊ 2745:: 2356:2 2354:H 2347:) 2343:( 2328:e 2321:t 2314:v 2297:. 2277:: 2251:. 2225:. 2199:. 2173:. 2147:. 2122:. 2078:. 2034:. 2007:. 1980:. 1954:. 1928:. 1906:: 1879:. 1848:. 1846:. 1821:. 1801:: 1778:. 1753:. 1721:. 1689:. 1669:: 1646:. 1621:. 1591:. 1564:. 1535:. 1508:. 1471:. 1434:. 1405:. 1166:( 1136:) 753:) 730:S 727:2 724:O 721:3 718:N 715:3 712:F 706:H 700:C 646:) 642:( 442:H 382:( 326:: 313:: 304:: 220:: 147:/ 108:/ 105:l 99:z 96:ə 93:r 90:p 84:s 81:ˈ 78:n 75:æ 72:l 69:/ 20:)

Index

Prevacid


/lænˈsprəzl/
lan-SOH-prə-zohl
Trade names
AHFS
Drugs.com
Monograph
MedlinePlus
a695020
License data
DailyMed
Lansoprazole
Pregnancy
category

Routes of
administration

By mouth
intravenous
Drug class
Proton pump inhibitor
ATC code
A02BC03
WHO
Legal status
POM
WARNING
Pharmacokinetic
Bioavailability
Protein binding
Metabolism

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