Knowledge

Procyclin

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1360: 1161:
EP1 is a 141 amino acids protein and EP2 is a 129 AA protein. Both proteins have their coding genes situated on chromosome 10. GPEET2 is a 114 AA protein and EP3-2 is 123 AA protein with genes situated on chromosome 6.
1193:"Procyclic acidic repetitive protein (PARP) genes located in an unusually small alpha-amanitin-resistant transcription unit: PARP promoter activity assayed by transient DNA transfection of Trypanosoma brucei" 96: 1009: 997: 706: 694: 406: 394: 187: 175: 441: 222: 1044: 741: 1401: 1115:
which is replaced by an equally dense coat of procyclins when the parasite differentiates into the procylic form in the tsetse fly midgut.
1246:"The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly" 990: 687: 387: 168: 1420: 116: 1171: 1112: 1425: 1394: 1305:"'GPEET' procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427" 969: 887: 804: 666: 585: 504: 366: 285: 147: 104: 1430: 1118:
There are six or seven procyclin genes that encode unusual proteins with extensive tandem repeat units of
1387: 100: 1257: 650: 1143: 1135: 1127: 569: 350: 131: 1103: 1334: 1285: 1222: 91: 1324: 1316: 1275: 1265: 1212: 1204: 1155: 952: 1151: 1147: 1139: 1131: 870: 787: 487: 268: 83: 1064: 927: 844: 761: 625: 544: 461: 325: 242: 1261: 1371: 1329: 1304: 1217: 1192: 1414: 1280: 1245: 1119: 45: 1241: 1014: 1002: 711: 699: 411: 399: 192: 180: 79: 1191:
Rudenko G, Le Blancq S, Smith J, Lee MG, Rattray A, Van der Ploeg LH (July 1990).
57: 1154:), and two genes that encode proteins with internal pentapeptide GPEET repeats ( 1074: 937: 854: 771: 635: 554: 471: 335: 252: 1108: 1038: 1021: 903: 820: 735: 718: 601: 520: 435: 418: 301: 216: 199: 1289: 1270: 1240:
Acosta-Serrano A, Vassella E, Liniger M, Kunz Renggli C, Brun R, Roditi I,
1338: 1226: 1208: 1111:
vector. The cell surface of the bloodstream form features a dense coat of
1026: 908: 825: 723: 606: 525: 423: 306: 204: 52: 1367: 1123: 1098: 1359: 1320: 985: 682: 382: 163: 111: 73: 40: 1303:
Bütikofer P, Ruepp S, Boschung M, Roditi I (September 1997).
1375: 1070: 1060: 1055: 1037: 1032: 1020: 1008: 996: 984: 976: 964: 959: 951: 933: 923: 918: 902: 894: 882: 877: 868: 850: 840: 835: 819: 811: 799: 794: 785: 767: 757: 752: 734: 729: 717: 705: 693: 681: 673: 661: 656: 649: 631: 621: 616: 600: 592: 580: 575: 568: 550: 540: 535: 519: 511: 499: 494: 485: 467: 457: 452: 434: 429: 417: 405: 393: 381: 373: 361: 356: 349: 331: 321: 316: 300: 292: 280: 275: 266: 248: 238: 233: 215: 210: 198: 186: 174: 162: 154: 142: 137: 130: 110: 90: 72: 67: 51: 39: 31: 26: 21: 1395: 8: 1402: 1388: 1052: 915: 832: 749: 613: 532: 449: 313: 230: 64: 1328: 1279: 1269: 1216: 1183: 948: 865: 782: 646: 565: 482: 346: 263: 127: 18: 16:Surface coating protein of trypanosome 1113:variable surface glycoproteins (VSGs) 7: 1356: 1354: 1101:developed in the surface coating of 1091:procyclic acidic repetitive proteins 14: 1358: 1126:(P), referred to as EP repeats ( 1: 1172:Coat protein (disambiguation) 68:Available protein structures: 1374:. You can help Knowledge by 1250:Proc. Natl. Acad. Sci. U.S.A 22:Procyclic acidic repetitive 1447: 1353: 980:Tb927.6.510, Tb06.28F21.90 1107:parasites while in their 1051: 914: 831: 748: 612: 531: 448: 312: 229: 63: 1421:Kinetoplastid proteins 1370:-related article is a 1271:10.1073/pnas.98.4.1513 1209:10.1128/MCB.10.7.3492 1426:Parasitic excavates 1262:2001PNAS...98.1513A 955:procyclin precursor 1104:Trypanosoma brucei 970:Trypanosoma brucei 888:Trypanosoma brucei 805:Trypanosoma brucei 667:Trypanosoma brucei 586:Trypanosoma brucei 505:Trypanosoma brucei 442:10: 2.48 - 2.48 Mb 367:Trypanosoma brucei 286:Trypanosoma brucei 223:10: 2.48 - 2.48 Mb 148:Trypanosoma brucei 1383: 1382: 1321:10.1042/bj3260415 1244:(February 2001). 1084: 1083: 1080: 1079: 1045:6: 0.23 - 0.23 Mb 947: 946: 943: 942: 864: 863: 860: 859: 781: 780: 777: 776: 742:6: 0.23 - 0.23 Mb 645: 644: 641: 640: 564: 563: 560: 559: 481: 480: 477: 476: 345: 344: 341: 340: 262: 261: 258: 257: 126: 125: 122: 121: 117:structure summary 1438: 1404: 1397: 1390: 1362: 1355: 1343: 1342: 1332: 1300: 1294: 1293: 1283: 1273: 1237: 1231: 1230: 1220: 1188: 1053: 972: 949: 916: 890: 869:Surface protein 866: 833: 807: 786:Surface protein 783: 750: 669: 647: 614: 588: 566: 533: 507: 486:Surface protein 483: 450: 369: 347: 314: 288: 267:Surface protein 264: 231: 150: 128: 65: 19: 1446: 1445: 1441: 1440: 1439: 1437: 1436: 1435: 1411: 1410: 1409: 1408: 1352: 1347: 1346: 1302: 1301: 1297: 1239: 1238: 1234: 1203:(7): 3492–504. 1197:Mol. Cell. Biol 1190: 1189: 1185: 1180: 1168: 968: 886: 803: 665: 651:EP3-2 procyclin 584: 503: 365: 284: 146: 17: 12: 11: 5: 1444: 1442: 1434: 1433: 1428: 1423: 1413: 1412: 1407: 1406: 1399: 1392: 1384: 1381: 1380: 1363: 1351: 1350:External links 1348: 1345: 1344: 1295: 1232: 1182: 1181: 1179: 1176: 1175: 1174: 1167: 1164: 1089:also known as 1082: 1081: 1078: 1077: 1072: 1068: 1067: 1062: 1058: 1057: 1049: 1048: 1041: 1035: 1034: 1030: 1029: 1024: 1018: 1017: 1012: 1006: 1005: 1000: 994: 993: 988: 982: 981: 978: 974: 973: 966: 962: 961: 957: 956: 945: 944: 941: 940: 935: 931: 930: 925: 921: 920: 912: 911: 906: 900: 899: 896: 892: 891: 884: 880: 879: 875: 874: 862: 861: 858: 857: 852: 848: 847: 842: 838: 837: 829: 828: 823: 817: 816: 813: 809: 808: 801: 797: 796: 792: 791: 779: 778: 775: 774: 769: 765: 764: 759: 755: 754: 746: 745: 738: 732: 731: 727: 726: 721: 715: 714: 709: 703: 702: 697: 691: 690: 685: 679: 678: 675: 671: 670: 663: 659: 658: 654: 653: 643: 642: 639: 638: 633: 629: 628: 623: 619: 618: 610: 609: 604: 598: 597: 594: 590: 589: 582: 578: 577: 573: 572: 562: 561: 558: 557: 552: 548: 547: 542: 538: 537: 529: 528: 523: 517: 516: 513: 509: 508: 501: 497: 496: 492: 491: 479: 478: 475: 474: 469: 465: 464: 459: 455: 454: 446: 445: 438: 432: 431: 427: 426: 421: 415: 414: 409: 403: 402: 397: 391: 390: 385: 379: 378: 377:Tb10.6k15.0030 375: 371: 370: 363: 359: 358: 354: 353: 343: 342: 339: 338: 333: 329: 328: 323: 319: 318: 310: 309: 304: 298: 297: 294: 290: 289: 282: 278: 277: 273: 272: 260: 259: 256: 255: 250: 246: 245: 240: 236: 235: 227: 226: 219: 213: 212: 208: 207: 202: 196: 195: 190: 184: 183: 178: 172: 171: 166: 160: 159: 158:Tb10.6k15.0020 156: 152: 151: 144: 140: 139: 135: 134: 124: 123: 120: 119: 114: 108: 107: 94: 88: 87: 77: 70: 69: 61: 60: 55: 49: 48: 43: 37: 36: 33: 29: 28: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1443: 1432: 1431:Protein stubs 1429: 1427: 1424: 1422: 1419: 1418: 1416: 1405: 1400: 1398: 1393: 1391: 1386: 1385: 1379: 1377: 1373: 1369: 1364: 1361: 1357: 1349: 1340: 1336: 1331: 1326: 1322: 1318: 1315:(2): 415–23. 1314: 1310: 1306: 1299: 1296: 1291: 1287: 1282: 1277: 1272: 1267: 1263: 1259: 1256:(4): 1513–8. 1255: 1251: 1247: 1243: 1236: 1233: 1228: 1224: 1219: 1214: 1210: 1206: 1202: 1198: 1194: 1187: 1184: 1177: 1173: 1170: 1169: 1165: 1163: 1159: 1157: 1153: 1149: 1145: 1141: 1137: 1133: 1129: 1125: 1121: 1120:glutamic acid 1116: 1114: 1110: 1106: 1105: 1100: 1096: 1092: 1088: 1076: 1073: 1069: 1066: 1063: 1059: 1054: 1050: 1047: 1046: 1042: 1040: 1036: 1031: 1028: 1025: 1023: 1019: 1016: 1013: 1011: 1010:RefSeq (Prot) 1007: 1004: 1001: 999: 998:RefSeq (mRNA) 995: 992: 989: 987: 983: 979: 975: 971: 967: 963: 958: 954: 950: 939: 936: 932: 929: 926: 922: 917: 913: 910: 907: 905: 901: 897: 893: 889: 885: 881: 876: 872: 867: 856: 853: 849: 846: 843: 839: 834: 830: 827: 824: 822: 818: 814: 810: 806: 802: 798: 793: 789: 784: 773: 770: 766: 763: 760: 756: 751: 747: 744: 743: 739: 737: 733: 728: 725: 722: 720: 716: 713: 710: 708: 707:RefSeq (Prot) 704: 701: 698: 696: 695:RefSeq (mRNA) 692: 689: 686: 684: 680: 676: 672: 668: 664: 660: 655: 652: 648: 637: 634: 630: 627: 624: 620: 615: 611: 608: 605: 603: 599: 595: 591: 587: 583: 579: 574: 571: 570:Procyclin EP3 567: 556: 553: 549: 546: 543: 539: 534: 530: 527: 524: 522: 518: 514: 510: 506: 502: 498: 493: 489: 484: 473: 470: 466: 463: 460: 456: 451: 447: 444: 443: 439: 437: 433: 428: 425: 422: 420: 416: 413: 410: 408: 407:RefSeq (Prot) 404: 401: 398: 396: 395:RefSeq (mRNA) 392: 389: 386: 384: 380: 376: 372: 368: 364: 360: 355: 352: 351:EP2 procyclin 348: 337: 334: 330: 327: 324: 320: 315: 311: 308: 305: 303: 299: 295: 291: 287: 283: 279: 274: 270: 265: 254: 251: 247: 244: 241: 237: 232: 228: 225: 224: 220: 218: 214: 209: 206: 203: 201: 197: 194: 191: 189: 188:RefSeq (Prot) 185: 182: 179: 177: 176:RefSeq (mRNA) 173: 170: 167: 165: 161: 157: 153: 149: 145: 141: 136: 133: 132:EP1 procyclin 129: 118: 115: 113: 109: 106: 102: 98: 95: 93: 89: 85: 81: 78: 75: 71: 66: 62: 59: 56: 54: 50: 47: 44: 42: 38: 34: 30: 25: 20: 1376:expanding it 1365: 1312: 1308: 1298: 1253: 1249: 1235: 1200: 1196: 1186: 1160: 1117: 1102: 1094: 1090: 1086: 1085: 1043: 740: 440: 221: 1065:Swiss-model 1015:XP_845174.1 1003:XM_840081.1 960:Identifiers 928:Swiss-model 878:Identifiers 845:Swiss-model 795:Identifiers 762:Swiss-model 712:XP_845175.1 700:XM_840082.1 677:Tb927.6.520 657:Identifiers 626:Swiss-model 576:Identifiers 545:Swiss-model 495:Identifiers 462:Swiss-model 412:XP_823246.1 400:XM_818153.1 357:Identifiers 326:Swiss-model 276:Identifiers 243:Swiss-model 193:XP_823247.1 181:XM_818154.1 138:Identifiers 27:Identifiers 1415:Categories 1309:Biochem. J 1242:Englund PT 1178:References 1109:tsetse fly 1087:Procyclins 1061:Structures 1056:Search for 1039:Chromosome 1033:Other data 924:Structures 919:Search for 841:Structures 836:Search for 758:Structures 753:Search for 736:Chromosome 730:Other data 622:Structures 617:Search for 541:Structures 536:Search for 458:Structures 453:Search for 436:Chromosome 430:Other data 322:Structures 317:Search for 239:Structures 234:Search for 217:Chromosome 211:Other data 80:structures 873:procyclin 790:procyclin 490:procyclin 271:procyclin 58:IPR008882 1290:11171982 1166:See also 1122:(E) and 1099:proteins 1075:InterPro 965:Organism 938:InterPro 883:Organism 855:InterPro 800:Organism 772:InterPro 662:Organism 636:InterPro 581:Organism 555:InterPro 500:Organism 472:InterPro 362:Organism 336:InterPro 281:Organism 253:InterPro 143:Organism 97:RCSB PDB 53:InterPro 1368:protein 1339:9291113 1330:1218686 1258:Bibcode 1227:1694012 1124:proline 1071:Domains 1022:UniProt 991:3657686 934:Domains 904:UniProt 851:Domains 821:UniProt 768:Domains 719:UniProt 688:3657688 632:Domains 602:UniProt 551:Domains 521:UniProt 468:Domains 419:UniProt 388:3661534 332:Domains 302:UniProt 249:Domains 200:UniProt 169:3661797 46:PF05887 1337:  1327:  1288:  1278:  1225:  1218:360784 1215:  1156:GPEET2 1027:Q581F9 986:Entrez 977:Symbol 953:GPEET2 909:Q95PJ3 895:Symbol 826:Q95NW2 812:Symbol 724:Q581F6 683:Entrez 674:Symbol 607:Q86MA3 593:Symbol 526:Q95PJ2 512:Symbol 424:Q389V2 383:Entrez 374:Symbol 307:Q7KG35 293:Symbol 205:Q389V1 164:Entrez 155:Symbol 112:PDBsum 86:  76:  32:Symbol 1366:This 1281:29288 1152:EP3-4 1148:EP3-2 1140:EP2-1 1132:EP1-2 898:EP3-4 871:EP3-4 815:EP3-3 788:EP3-3 515:EP2-1 488:EP2-1 296:EP1-2 269:EP1-2 1372:stub 1335:PMID 1286:PMID 1223:PMID 1097:are 1095:PARP 105:PDBj 101:PDBe 84:ECOD 74:Pfam 41:Pfam 1325:PMC 1317:doi 1313:326 1276:PMC 1266:doi 1213:PMC 1205:doi 1158:). 1144:EP3 1136:EP2 1128:EP1 1093:or 596:EP3 92:PDB 1417:: 1333:. 1323:. 1311:. 1307:. 1284:. 1274:. 1264:. 1254:98 1252:. 1248:. 1221:. 1211:. 1201:10 1199:. 1195:. 1150:, 1146:, 1142:, 1138:, 1134:, 1130:, 103:; 99:; 82:/ 1403:e 1396:t 1389:v 1378:. 1341:. 1319:: 1292:. 1268:: 1260:: 1229:. 1207:: 35:?

Index

Pfam
PF05887
InterPro
IPR008882
Pfam
structures
ECOD
PDB
RCSB PDB
PDBe
PDBj
PDBsum
structure summary
EP1 procyclin
Trypanosoma brucei
Entrez
3661797
RefSeq (mRNA)
XM_818154.1
RefSeq (Prot)
XP_823247.1
UniProt
Q389V1
Chromosome
10: 2.48 - 2.48 Mb
Swiss-model
InterPro
EP1-2
Trypanosoma brucei
UniProt

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