304:
281:
178:
203:
555:
310:
209:
31:
2912:
1136:
Prolactin induced protein (called GCDFP-15 in this context) in breast cyst fluid or breast tissue serves as marker of both benign and malignant apocrine metaplasia as the protein is not normally expressed in breast tissue. It is characteristic of low grade apocrine carcinoma of the breast, high grade
1098:
The protein has a physiological function in regulation of water transport mainly in apocrine glands in the axilla, vulva, eyelid and ear canal, serous cells of the submandibular salivary gland, serous cells of the submucosal glands of the bronchi, and accessory lacrimal glands as well as cutaneous
1137:
apocrine carcinoma frequently lose expression of this marker. PIP gene expression in breast cancer lines was associated with decreased cell proliferation and invasiveness and an increase of the apoptotic pathway. Many of the genes affected by PIP appear to be regulated by
57:
1624:
Schenkels LC, Walgreen-Weterings E, Oomen LC, Bolscher JG, Veerman EC, Nieuw
Amerongen AV (February 1997). "In vivo binding of the salivary glycoprotein EP-GP (identical to GCDFP-15) to oral and non-oral bacteria detection and identification of EP-GP binding species".
2812:
Schenkels LC, Walgreen-Weterings E, Oomen LC, Bolscher JG, Veerman EC, Nieuw
Amerongen AV (1997). "In vivo binding of the salivary glycoprotein EP-GP (identical to GCDFP-15) to oral and non-oral bacteria detection and identification of EP-GP binding species".
1152:
The PIP gene is amplified in some breast cancer lines accounting for some of its overexpression, however additional mechanisms are needed to completely explain its overexpression. In T47D breast cancer cells, androgen receptor and
1715:
Collette J, Hendrick JC, Jaspar JM, Franchimont P (July 1986). "Presence of alpha-lactalbumin, epidermal growth factor, epithelial membrane antigen, and gross cystic disease fluid protein (15,000 daltons) in breast cyst fluid".
1144:
A mitogenic effect of this protein on experimental breast cells lines MCF10A, MCF7, BT474, MDA-MB231 and T47D was detected. Prolactin-induced protein has also been used for identification and detection of disseminated
1770:
Honma N, Takubo K, Arai T, Younes M, Kasumi F, Akiyama F, Sakamoto G (2006). "Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast".
1671:
Cassoni P, Sapino A, Haagensen DE, Naldoni C, Bussolati G (January 1995). "Mitogenic effect of the 15-kDa gross cystic disease fluid protein (GCDFP-15) on breast-cancer cell lines and on immortal mammary cells".
2284:
Gaubin M, Autiero M, Basmaciogullari S, et al. (1999). "Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells".
1513:
Caputo E, Camarca A, Moharram R, Tornatore P, Thatcher B, Guardiola J, Martin BM (May 2003). "Structural study of GCDFP-15/gp17 in disease versus physiological conditions using a proteomic approach".
1743:
Petrakis NL, Lowenstein JM, Wiencke JK, Lee MM, Wrensch MR, King EB, Hilton JF, Miike R (1993). "Gross cystic disease fluid protein in nipple aspirates of breast fluid of Asian and non-Asian women".
1175:
In ER+ breast cancer, particularly those with very high level of ER expression, PIP appears to play an important role in proliferation and invasion as well as acquired resistance to
1921:"Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I"
1125:
PIP can bind different species of bacteria showing highest affinity to streptococci thus playing a role in non-immune defense of the body against pathogenic bacterial strains.
2348:
Basmaciogullari S, Autiero M, Culerrier R, et al. (2000). "Mapping the CD4 binding domain of gp17, a glycoprotein secreted from seminal vesicles and breast carcinomas".
1273:
Myal Y, Gregory C, Wang H, Hamerton JL, Shiu RP (July 1989). "The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7".
317:
216:
1379:"Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features"
1316:
Myal Y, Robinson DB, Iwasiow B, Tsuyuki D, Wong P, Shiu RP (January 1992). "The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation".
2711:
Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry".
2160:"Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D"
1919:
Ciullo M, Debily MA, Rozier L, Autiero M, Billault A, Mayau V, El
Marhomy S, Guardiola J, Bernheim A, Coullin P, Piatier-Tonneau D, Debatisse M (November 2002).
2559:
Caputo E, Camarca A, Moharram R, et al. (2003). "Structural study of GCDFP-15/gp17 in disease versus physiological conditions using a proteomic approach".
2251:"Differential antibody reactivity and CD4 binding of the mammary tumor marker protein GCDFP-15 from breast cyst and its counterparts from exocrine epithelia"
2228:
Autiero M, Bouchier C, Basmaciogullari S, et al. (1997). "Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor".
2414:"Intragenic amplification and formation of extrachromosomal small circular DNA molecules from the PIP gene on chromosome 7 in primary breast carcinomas"
783:
1110:
PIP has the ability to bind immunoglobulin G (IgG), IgG-Fc, CD4-T cell receptor suggesting a wide range of immunological functions. PIP also binds to
764:
139:
1589:
Lee B, Bowden GH, Myal Y (April 2002). "Identification of mouse submaxillary gland protein in mouse saliva and its binding to mouse oral bacteria".
2783:
Lee B, Bowden GH, Myal Y (2002). "Identification of mouse submaxillary gland protein in mouse saliva and its binding to mouse oral bacteria".
2891:
1255:
1165:
1237:
2940:
2267:
2250:
1172:
which can be inhibited by anti-androgens. PIP expression is necessary for viability and invasiveness of this subtype of breast cancer.
983:
303:
990:
2666:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
280:
2062:"Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner"
1359:
1962:"Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation"
1418:
Chiu WW, Chamley LW (December 2003). "Human seminal plasma prolactin-inducible protein is an immunoglobulin G-binding protein".
2379:"AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain"
2011:"Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer"
1224:
1203:
1220:
202:
177:
54:
2950:
1814:
Debily MA, Marhomy SE, Boulanger V, Eveno E, Mariage-Samson R, Camarca A, Auffray C, Piatier-Tonneau D, Imbeaud S (2009).
1458:"Prolactin inducible protein in cancer, fertility and immunoregulation: structure, function and its clinical implications"
1199:
119:
316:
215:
2884:
1873:
309:
208:
828:
127:
2590:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
809:
2877:
2675:
2521:
2468:
2073:
1827:
191:
106:
2633:"GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol"
2838:
2699:
2443:
1901:
1796:
1697:
1650:
1495:
1341:
1298:
1115:
151:
2457:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
966:
945:
919:
898:
2945:
2830:
2800:
2771:
2728:
2691:
2654:
2619:
2576:
2547:
2496:
2435:
2400:
2365:
2336:
2301:
2272:
2237:
2216:
2181:
2146:
2101:
2042:
1991:
1942:
1893:
1855:
1788:
1752:
1725:
1689:
1642:
1606:
1571:
1530:
1487:
1435:
1400:
1333:
1290:
1161:
99:
47:
2822:
2792:
2761:
2753:
2720:
2683:
2644:
2609:
2601:
2568:
2537:
2529:
2486:
2476:
2425:
2390:
2357:
2326:
2293:
2262:
2206:
2171:
2136:
2091:
2081:
2032:
2022:
1981:
1973:
1932:
1885:
1876:(December 2006). "Significance, detection and markers of disseminated breast cancer cells".
1845:
1835:
1780:
1681:
1634:
1598:
1561:
1522:
1477:
1469:
1427:
1390:
1374:
1325:
1282:
396:
327:
271:
226:
1816:"A functional and regulatory network associated with PIP expression in human breast cancer"
1128:
Mitogenic effect of PIP was observed on both normal and malignant breast epithelial cells.
371:
2863:
2857:
147:
2911:
2679:
2525:
2472:
2077:
1831:
1482:
1457:
1160:
In molecular apocrine breast cancer (ER-/AR+) there is a positive feedback loop between
554:
110:, GCDFP-15, GCDFP15, GPIP4, Prolactin-induced protein, prolactin induced protein, BRST-2
2766:
2741:
2542:
2509:
2141:
2124:
2096:
2061:
2037:
2010:
1986:
1961:
1850:
1815:
1784:
1395:
1378:
1100:
2796:
2614:
2589:
2491:
2456:
2195:"2006 expressed-sequence tags derived from human chromosome 7-enriched cDNA libraries"
2176:
2159:
1602:
1431:
698:
693:
688:
683:
678:
673:
668:
652:
647:
642:
637:
632:
616:
611:
606:
601:
596:
2934:
1329:
1146:
1104:
583:
2842:
2447:
1905:
1800:
1701:
1654:
1345:
1302:
30:
2703:
1499:
1052:
389:
168:
131:
2086:
1840:
155:
2742:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
2297:
1260:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1242:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1119:
2826:
1638:
472:
1473:
288:
185:
135:
1937:
1920:
689:
detection of chemical stimulus involved in sensory perception of bitter taste
2533:
2331:
2314:
2125:"Primary structure of a new actin-binding protein from human seminal plasma"
1566:
1549:
1176:
1083:
1079:
728:
532:
410:
355:
342:
254:
241:
143:
2804:
2775:
2732:
2695:
2658:
2649:
2632:
2623:
2580:
2551:
2500:
2481:
2439:
2404:
2395:
2378:
2369:
2340:
2305:
2105:
2046:
1995:
1946:
1897:
1859:
1792:
1685:
1610:
1575:
1534:
1491:
1439:
2834:
2276:
2268:
10.1002/(SICI)1097-0215(19980925)78:1<76::AID-IJC13>3.0.CO;2-3
2241:
2220:
2185:
2150:
1756:
1729:
1693:
1646:
1404:
1337:
1294:
1030:
1025:
1087:
1014:
873:
854:
2687:
1889:
2757:
2605:
2315:"A novel aspartyl proteinase from apocrine epithelia and breast tumors"
2211:
2194:
1550:"A novel aspartyl proteinase from apocrine epithelia and breast tumors"
1286:
1068:
840:
795:
2724:
2572:
2430:
2413:
2361:
1977:
1526:
76:
998:
750:
2027:
1169:
1154:
1138:
1111:
1456:
Hassan MI, Waheed A, Yadav S, Singh TP, Ahmad F (February 2009).
713:
709:
2060:
Baniwal SK, Chimge NO, Jordan VC, Tripathy D, Frenkel B (2013).
1075:
123:
2873:
563:
2869:
2193:
Touchman JW, Bouffard GG, Weintraub LA, et al. (1997).
2455:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1548:
Caputo E, Manco G, Mandrich L, Guardiola J (March 2000).
2508:
Scherer SW, Cheung J, MacDonald JR, et al. (2003).
1960:
Baniwal SK, Little GH, Chimge NO, Frenkel B (May 2012).
379:
2588:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
2123:
Schaller J, Akiyama K, Kimura H, et al. (1991).
544:
2412:
Autiero M, Camarca A, Ciullo M, et al. (2002).
1157:
interact to synergistically enhance PIP expression.
2313:Caputo E, Manco G, Mandrich L, Guardiola J (2000).
959:
938:
912:
891:
2631:Shishioh N, Hong Y, Ohishi K, et al. (2005).
2249:Caputo E, Autiero M, Mani JC, et al. (1998).
1216:
1214:
1212:
1195:
1193:
1191:
326:
225:
2740:Ewing RM, Chu P, Elisma F, et al. (2007).
1666:
1664:
669:negative regulation of T cell apoptotic process
2510:"Human chromosome 7: DNA sequence and biology"
2158:Murphy LC, Tsuyuki D, Myal Y, Shiu RP (1987).
1221:GRCm38: Ensembl release 89: ENSMUSG00000058499
2885:
8:
1360:"Entrez Gene: PIP prolactin-induced protein"
1200:GRCh38: Ensembl release 89: ENSG00000159763
2892:
2878:
2870:
724:
579:
367:
266:
163:
65:
2765:
2648:
2613:
2541:
2490:
2480:
2429:
2394:
2330:
2266:
2210:
2175:
2140:
2095:
2085:
2036:
2026:
1985:
1936:
1849:
1839:
1565:
1481:
1451:
1449:
1394:
1377:, Davis S, Haagensen DE (February 1983).
1132:Use as marker and significance in disease
2907:
1187:
18:Mammalian protein found in Homo sapiens
684:positive regulation of gene expression
20:
1166:extracellular signal-regulated kinase
1047:gross cystic disease fluid protein 15
331:
292:
287:
230:
189:
184:
7:
1099:eccrine glands. It is also found in
617:aspartic-type endopeptidase activity
674:regulation of immune system process
2142:10.1111/j.1432-1033.1991.tb15873.x
1785:10.1111/j.1600-0463.2006.apm_434.x
956:
935:
909:
888:
864:
845:
819:
800:
774:
755:
549:
467:
405:
384:
14:
1745:Cancer Epidemiol. Biomarkers Prev
1071:that in humans is encoded by the
2910:
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
2377:Rieske P, Pongubala JM (2001).
564:More reference expression data
533:More reference expression data
429:olfactory zone of nasal mucosa
1:
2797:10.1016/S0003-9969(01)00113-3
2177:10.1016/S0021-9258(18)48164-1
1603:10.1016/S0003-9969(01)00113-3
1432:10.1016/S0165-0378(03)00084-6
1061:seminal actin-binding protein
607:protein dimerization activity
300:
199:
2461:Proc. Natl. Acad. Sci. U.S.A
2087:10.1371/journal.pone.0062361
1841:10.1371/journal.pone.0004696
1330:10.1016/0303-7207(91)90153-J
2941:Genes on human chromosome 7
2298:10.4049/jimmunol.162.5.2631
1043:Prolactin-inducible protein
2967:
2827:10.1515/bchm.1997.378.2.83
2009:Naderi A, Meyer M (2012).
1639:10.1515/bchm.1997.378.2.83
507:sexually immature organism
2905:
1474:10.1007/s00018-008-8463-x
1256:"Mouse PubMed Reference:"
1238:"Human PubMed Reference:"
1029:
1024:
1020:
1013:
997:
984:Chr 7: 143.13 – 143.14 Mb
978:
963:
942:
931:
916:
895:
884:
871:
867:
852:
848:
839:
826:
822:
807:
803:
794:
781:
777:
762:
758:
749:
734:
727:
723:
707:
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
1118:activity able to cleave
2864:GCDFP-15 immunostaining
2534:10.1126/science.1083423
2332:10.1074/jbc.275.11.7935
1567:10.1074/jbc.275.11.7935
1078:. It is upregulated by
991:Chr 6: 41.82 – 41.83 Mb
694:transmembrane transport
2650:10.1074/jbc.M413755200
2482:10.1073/pnas.242603899
2396:10.1074/jbc.M007482200
1938:10.1093/hmg/11.23.2887
1686:10.1002/ijc.2910600215
638:apical plasma membrane
333:6 B2.1|6 20.05 cM
1878:Endocr. Relat. Cancer
1086:and downregulated by
643:extracellular exosome
441:palpebral conjunctiva
2951:Cutaneous conditions
2858:BRST2 immunostaining
1275:Somat Cell Mol Genet
633:extracellular region
499:olfactory epithelium
294:Chromosome 6 (mouse)
192:Chromosome 7 (human)
69:List of PDB id codes
42:Available structures
2688:10.1038/nature04209
2680:2005Natur.437.1173R
2526:2003Sci...300..767S
2473:2002PNAS...9916899M
2078:2013PLoSO...862361B
1890:10.1677/ERC-06-0001
1832:2009PLoSO...4.4696D
1462:Cell. Mol. Life Sci
1318:Mol Cell Endocrinol
1116:aspartyl proteinase
653:extracellular space
491:submandibular gland
2866:- immunosaver.com.
2758:10.1038/msb4100134
2606:10.1101/gr.2596504
2212:10.1101/gr.7.3.281
1420:J. Reprod. Immunol
1287:10.1007/BF01534877
829:ENSMUSG00000058499
679:retina homeostasis
662:Biological process
626:Cellular component
590:Molecular function
2928:
2927:
2725:10.1021/pr050492k
2573:10.1021/bi034038a
2467:(26): 16899–903.
2431:10.1002/ijc.10368
2362:10.1021/bi992398l
2015:Breast Cancer Res
1978:10.1002/jcp.22966
1527:10.1021/bi034038a
1162:androgen receptor
1040:
1039:
1036:
1035:
1009:
1008:
974:
973:
953:
952:
927:
926:
906:
905:
880:
879:
861:
860:
835:
834:
816:
815:
790:
789:
771:
770:
719:
718:
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
2958:
2914:
2894:
2887:
2880:
2871:
2846:
2808:
2779:
2769:
2736:
2707:
2674:(7062): 1173–8.
2662:
2652:
2627:
2617:
2584:
2555:
2545:
2520:(5620): 767–72.
2504:
2494:
2484:
2451:
2433:
2408:
2398:
2373:
2344:
2334:
2309:
2280:
2270:
2245:
2224:
2214:
2189:
2179:
2170:(31): 15236–41.
2154:
2144:
2110:
2109:
2099:
2089:
2057:
2051:
2050:
2040:
2030:
2006:
2000:
1999:
1989:
1966:J. Cell. Physiol
1957:
1951:
1950:
1940:
1916:
1910:
1909:
1870:
1864:
1863:
1853:
1843:
1811:
1805:
1804:
1767:
1761:
1760:
1740:
1734:
1733:
1712:
1706:
1705:
1668:
1659:
1658:
1621:
1615:
1614:
1586:
1580:
1579:
1569:
1545:
1539:
1538:
1510:
1504:
1503:
1485:
1453:
1444:
1443:
1415:
1409:
1408:
1398:
1370:
1364:
1363:
1356:
1350:
1349:
1313:
1307:
1306:
1270:
1264:
1263:
1252:
1246:
1245:
1234:
1228:
1218:
1207:
1197:
1022:
1021:
993:
986:
969:
957:
948:
936:
932:RefSeq (protein)
922:
910:
901:
889:
865:
846:
820:
801:
775:
756:
725:
580:
566:
557:
550:
535:
511:digastric muscle
475:
473:Top expressed in
468:
457:lactiferous duct
421:seminal vesicula
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
109:
102:
79:
66:
60:
39:
38:
33:
21:
2966:
2965:
2961:
2960:
2959:
2957:
2956:
2955:
2931:
2930:
2929:
2924:
2921:
2915:
2901:
2898:
2854:
2849:
2811:
2782:
2746:Mol. Syst. Biol
2739:
2719:(6): 1493–503.
2713:J. Proteome Res
2710:
2665:
2643:(10): 9728–34.
2630:
2600:(10B): 2121–7.
2587:
2567:(20): 6169–78.
2558:
2507:
2454:
2411:
2376:
2356:(18): 5332–40.
2347:
2325:(11): 7935–41.
2312:
2283:
2248:
2227:
2192:
2157:
2129:Eur. J. Biochem
2122:
2118:
2116:Further reading
2113:
2059:
2058:
2054:
2028:10.1186/bcr3232
2008:
2007:
2003:
1959:
1958:
1954:
1931:(23): 2887–94.
1925:Hum. Mol. Genet
1918:
1917:
1913:
1872:
1871:
1867:
1813:
1812:
1808:
1769:
1768:
1764:
1742:
1741:
1737:
1714:
1713:
1709:
1670:
1669:
1662:
1623:
1622:
1618:
1591:Arch. Oral Biol
1588:
1587:
1583:
1560:(11): 7935–41.
1547:
1546:
1542:
1521:(20): 6169–78.
1512:
1511:
1507:
1455:
1454:
1447:
1417:
1416:
1412:
1372:
1371:
1367:
1358:
1357:
1353:
1324:(1–3): 165–75.
1315:
1314:
1310:
1272:
1271:
1267:
1254:
1253:
1249:
1236:
1235:
1231:
1219:
1210:
1198:
1189:
1185:
1134:
1096:
1031:View/Edit Mouse
1026:View/Edit Human
989:
982:
979:Location (UCSC)
965:
944:
918:
897:
810:ENSG00000159763
703:
657:
621:
602:protein binding
562:
531:
522:
517:
513:
509:
505:
503:masseter muscle
501:
497:
495:temporal muscle
493:
489:
485:
471:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
156:PIP - orthologs
118:
105:
98:
75:
53:
19:
12:
11:
5:
2964:
2962:
2954:
2953:
2948:
2943:
2933:
2932:
2926:
2925:
2923:
2922:
2916:
2909:
2906:
2903:
2902:
2899:
2897:
2896:
2889:
2882:
2874:
2868:
2867:
2861:
2853:
2852:External links
2850:
2848:
2847:
2809:
2785:Arch Oral Biol
2780:
2737:
2708:
2663:
2628:
2585:
2556:
2505:
2452:
2418:Int. J. Cancer
2409:
2389:(11): 8460–8.
2374:
2345:
2310:
2281:
2255:Int. J. Cancer
2246:
2230:Immunogenetics
2225:
2190:
2155:
2119:
2117:
2114:
2112:
2111:
2052:
2001:
1972:(5): 2276–82.
1952:
1911:
1884:(4): 1033–67.
1865:
1806:
1762:
1735:
1724:(7): 3728–33.
1707:
1674:Int. J. Cancer
1660:
1616:
1581:
1540:
1505:
1445:
1410:
1365:
1351:
1308:
1265:
1247:
1229:
1208:
1186:
1184:
1181:
1133:
1130:
1101:amniotic fluid
1095:
1092:
1051:extra-parotid
1045:also known as
1038:
1037:
1034:
1033:
1028:
1018:
1017:
1011:
1010:
1007:
1006:
1004:
1002:
995:
994:
987:
980:
976:
975:
972:
971:
961:
960:
954:
951:
950:
940:
939:
933:
929:
928:
925:
924:
914:
913:
907:
904:
903:
893:
892:
886:
882:
881:
878:
877:
869:
868:
862:
859:
858:
850:
849:
843:
837:
836:
833:
832:
824:
823:
817:
814:
813:
805:
804:
798:
792:
791:
788:
787:
779:
778:
772:
769:
768:
760:
759:
753:
747:
746:
741:
736:
732:
731:
721:
720:
717:
716:
705:
704:
702:
701:
696:
691:
686:
681:
676:
671:
665:
663:
659:
658:
656:
655:
650:
645:
640:
635:
629:
627:
623:
622:
620:
619:
614:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:lacrimal gland
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2963:
2952:
2949:
2947:
2944:
2942:
2939:
2938:
2936:
2919:
2913:
2908:
2904:
2895:
2890:
2888:
2883:
2881:
2876:
2875:
2872:
2865:
2862:
2859:
2856:
2855:
2851:
2844:
2840:
2836:
2832:
2828:
2824:
2820:
2816:
2810:
2806:
2802:
2798:
2794:
2791:(4): 327–32.
2790:
2786:
2781:
2777:
2773:
2768:
2763:
2759:
2755:
2751:
2747:
2743:
2738:
2734:
2730:
2726:
2722:
2718:
2714:
2709:
2705:
2701:
2697:
2693:
2689:
2685:
2681:
2677:
2673:
2669:
2664:
2660:
2656:
2651:
2646:
2642:
2638:
2637:J. Biol. Chem
2634:
2629:
2625:
2621:
2616:
2611:
2607:
2603:
2599:
2595:
2591:
2586:
2582:
2578:
2574:
2570:
2566:
2562:
2557:
2553:
2549:
2544:
2539:
2535:
2531:
2527:
2523:
2519:
2515:
2511:
2506:
2502:
2498:
2493:
2488:
2483:
2478:
2474:
2470:
2466:
2462:
2458:
2453:
2449:
2445:
2441:
2437:
2432:
2427:
2423:
2419:
2415:
2410:
2406:
2402:
2397:
2392:
2388:
2384:
2383:J. Biol. Chem
2380:
2375:
2371:
2367:
2363:
2359:
2355:
2351:
2346:
2342:
2338:
2333:
2328:
2324:
2320:
2319:J. Biol. Chem
2316:
2311:
2307:
2303:
2299:
2295:
2292:(5): 2631–8.
2291:
2287:
2282:
2278:
2274:
2269:
2264:
2260:
2256:
2252:
2247:
2243:
2239:
2235:
2231:
2226:
2222:
2218:
2213:
2208:
2205:(3): 281–92.
2204:
2200:
2196:
2191:
2187:
2183:
2178:
2173:
2169:
2165:
2164:J. Biol. Chem
2161:
2156:
2152:
2148:
2143:
2138:
2135:(3): 743–50.
2134:
2130:
2126:
2121:
2120:
2115:
2107:
2103:
2098:
2093:
2088:
2083:
2079:
2075:
2072:(6): e62361.
2071:
2067:
2063:
2056:
2053:
2048:
2044:
2039:
2034:
2029:
2024:
2020:
2016:
2012:
2005:
2002:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1953:
1948:
1944:
1939:
1934:
1930:
1926:
1922:
1915:
1912:
1907:
1903:
1899:
1895:
1891:
1887:
1883:
1879:
1875:
1869:
1866:
1861:
1857:
1852:
1847:
1842:
1837:
1833:
1829:
1825:
1821:
1817:
1810:
1807:
1802:
1798:
1794:
1790:
1786:
1782:
1779:(10): 712–9.
1778:
1774:
1766:
1763:
1758:
1754:
1750:
1746:
1739:
1736:
1731:
1727:
1723:
1719:
1711:
1708:
1703:
1699:
1695:
1691:
1687:
1683:
1680:(2): 216–20.
1679:
1675:
1667:
1665:
1661:
1656:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1620:
1617:
1612:
1608:
1604:
1600:
1597:(4): 327–32.
1596:
1592:
1585:
1582:
1577:
1573:
1568:
1563:
1559:
1555:
1554:J. Biol. Chem
1551:
1544:
1541:
1536:
1532:
1528:
1524:
1520:
1516:
1509:
1506:
1501:
1497:
1493:
1489:
1484:
1479:
1475:
1471:
1468:(3): 447–59.
1467:
1463:
1459:
1452:
1450:
1446:
1441:
1437:
1433:
1429:
1426:(2): 97–111.
1425:
1421:
1414:
1411:
1406:
1402:
1397:
1392:
1389:(2): 105–12.
1388:
1384:
1383:Am. J. Pathol
1380:
1376:
1373:Mazoujian G,
1369:
1366:
1361:
1355:
1352:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1312:
1309:
1304:
1300:
1296:
1292:
1288:
1284:
1281:(3): 265–70.
1280:
1276:
1269:
1266:
1261:
1257:
1251:
1248:
1243:
1239:
1233:
1230:
1226:
1222:
1217:
1215:
1213:
1209:
1205:
1201:
1196:
1194:
1192:
1188:
1182:
1180:
1178:
1173:
1171:
1167:
1163:
1158:
1156:
1150:
1148:
1147:breast cancer
1142:
1140:
1131:
1129:
1126:
1123:
1121:
1117:
1114:. PIP exerts
1113:
1108:
1106:
1105:seminal fluid
1102:
1093:
1091:
1089:
1085:
1081:
1077:
1074:
1070:
1066:
1062:
1059:
1055:
1054:
1048:
1044:
1032:
1027:
1023:
1019:
1016:
1012:
1005:
1003:
1000:
996:
992:
988:
985:
981:
977:
970:
968:
962:
958:
955:
949:
947:
941:
937:
934:
930:
923:
921:
915:
911:
908:
902:
900:
894:
890:
887:
885:RefSeq (mRNA)
883:
876:
875:
870:
866:
863:
857:
856:
851:
847:
844:
842:
838:
831:
830:
825:
821:
818:
812:
811:
806:
802:
799:
797:
793:
786:
785:
780:
776:
773:
767:
766:
761:
757:
754:
752:
748:
745:
742:
740:
737:
733:
730:
726:
722:
715:
711:
706:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
666:
664:
661:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
615:
613:
610:
608:
605:
603:
600:
598:
597:actin binding
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:parotid gland
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
437:skin of thigh
436:
432:
428:
425:parotid gland
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
2917:
2860:- abcam.com.
2818:
2814:
2788:
2784:
2749:
2745:
2716:
2712:
2671:
2667:
2640:
2636:
2597:
2593:
2564:
2561:Biochemistry
2560:
2517:
2513:
2464:
2460:
2424:(3): 370–7.
2421:
2417:
2386:
2382:
2353:
2350:Biochemistry
2349:
2322:
2318:
2289:
2285:
2261:(1): 76–85.
2258:
2254:
2236:(4): 345–8.
2233:
2229:
2202:
2198:
2167:
2163:
2132:
2128:
2069:
2065:
2055:
2018:
2014:
2004:
1969:
1965:
1955:
1928:
1924:
1914:
1881:
1877:
1868:
1826:(3): e4696.
1823:
1819:
1809:
1776:
1772:
1765:
1751:(6): 573–9.
1748:
1744:
1738:
1721:
1717:
1710:
1677:
1673:
1630:
1626:
1619:
1594:
1590:
1584:
1557:
1553:
1543:
1518:
1515:Biochemistry
1514:
1508:
1465:
1461:
1423:
1419:
1413:
1386:
1382:
1368:
1354:
1321:
1317:
1311:
1278:
1274:
1268:
1259:
1250:
1241:
1232:
1174:
1159:
1151:
1143:
1135:
1127:
1124:
1109:
1097:
1072:
1064:
1060:
1057:
1053:glycoprotein
1050:
1049:(GCDFP-15),
1046:
1042:
1041:
964:
943:
917:
896:
872:
853:
827:
808:
782:
763:
743:
738:
395:
388:
253:143,139,739
240:143,132,077
115:External IDs
74:
15:
2900:PDB gallery
2821:(2): 83–8.
2021:(4): R111.
1633:(2): 83–8.
1120:fibronectin
1063:(SABP) or
699:proteolysis
612:IgG binding
453:skin of hip
445:skin of arm
354:41,828,999
341:41,824,469
93:Identifiers
2935:Categories
2815:Biol. Chem
2594:Genome Res
2286:J. Immunol
2199:Genome Res
1718:Cancer Res
1627:Biol. Chem
1227:, May 2017
1206:, May 2017
1183:References
1168:(ERK) via
515:lymph node
399:(ortholog)
136:HomoloGene
2752:(1): 89.
1874:Lacroix M
1375:Pinkus GS
1177:tamoxifen
1084:androgens
1080:prolactin
1056:(EP-GP),
967:NP_032869
946:NP_002643
920:NM_008843
899:NM_002652
729:Orthologs
144:GeneCards
2946:Staining
2843:23667673
2805:11922875
2776:17353931
2733:16740002
2696:16189514
2659:15632136
2624:15489334
2581:12755619
2552:12690205
2501:12477932
2448:30723802
2440:11992405
2405:11133986
2370:10820003
2341:10713110
2306:10072505
2106:23755096
2066:PLOS ONE
2047:22817771
1996:21809344
1947:12393800
1906:10708900
1898:17158753
1860:19262752
1820:PLOS ONE
1801:21372161
1793:17004974
1702:44775922
1655:23667673
1611:11922875
1576:10713110
1535:12755619
1492:18854942
1483:11131491
1440:14638438
1346:37888783
1303:41577257
1223:–
1202:–
1094:Function
1088:estrogen
1015:Wikidata
708:Sources:
2835:9088536
2767:1847948
2704:4427026
2676:Bibcode
2543:2882961
2522:Bibcode
2514:Science
2469:Bibcode
2277:9724097
2242:9218538
2221:9074931
2186:3667631
2151:2013294
2097:3670933
2074:Bibcode
2038:3680918
1987:3376385
1851:2650800
1828:Bibcode
1757:8268776
1730:3486713
1694:7829219
1647:9088536
1500:5642491
1405:6130702
1396:1916150
1338:1955075
1295:2727805
1225:Ensembl
1204:Ensembl
1149:cells.
1069:protein
841:UniProt
796:Ensembl
735:Species
714:QuickGO
648:nucleus
519:trachea
433:trachea
374:pattern
100:Aliases
2841:
2833:
2803:
2774:
2764:
2731:
2702:
2694:
2668:Nature
2657:
2622:
2615:528928
2612:
2579:
2550:
2540:
2499:
2492:139241
2489:
2446:
2438:
2403:
2368:
2339:
2304:
2275:
2240:
2219:
2184:
2149:
2104:
2094:
2045:
2035:
1994:
1984:
1945:
1904:
1896:
1858:
1848:
1799:
1791:
1755:
1728:
1700:
1692:
1653:
1645:
1609:
1574:
1533:
1498:
1490:
1480:
1438:
1403:
1393:
1344:
1336:
1301:
1293:
1001:search
999:PubMed
874:P02816
855:P12273
751:Entrez
545:BioGPS
132:102696
124:176720
2839:S2CID
2700:S2CID
2444:S2CID
1902:S2CID
1797:S2CID
1773:APMIS
1698:S2CID
1651:S2CID
1496:S2CID
1342:S2CID
1299:S2CID
1170:CREB1
1155:RUNX2
1139:STAT5
1112:AZGP1
1067:is a
1065:BRST2
784:18716
744:Mouse
739:Human
710:Amigo
449:sperm
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
2918:2icn
2831:PMID
2801:PMID
2772:PMID
2729:PMID
2692:PMID
2655:PMID
2620:PMID
2577:PMID
2548:PMID
2497:PMID
2436:PMID
2401:PMID
2366:PMID
2337:PMID
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