307:
284:
181:
206:
313:
212:
2474:
26:
52:
1525:
Seidah NG, Mattei MG, Gaspar L, Benjannet S, Mbikay M, Chrétien M (September 1991). "Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7 region)".
1344:. Following the action of proprotein convertase 1, a carboxypeptidase is required to remove the basic residues from the processing intermediate and generate the bioactive form of insulin. Another prohormone convertase,
1333:
within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PC1 is synthesized as a 99
1427:
2128:
1360:
or humans, most likely due to the presence of the second convertase, although mice lacking proprotein convertase 1 activity show a number of defects including slow growth.
1988:
320:
219:
1211:
1728:
1367:(meaning that a serine residue is part of the active site that hydrolyzes the peptide bond within the substrate). It is related to the bacterial enzyme known as
1230:
1566:"Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements"
1337:
proform quickly converted to an 87 kDa major active form, which itself is nearly completely cleaved to a 66 kDa active form within neuroendocrine cells.
777:
758:
142:
1507:
1489:
1371:. There are nine subtilisin homologs in mammals; in addition to proprotein convertase 1 and 2, other members of this enzyme family include
2494:
306:
1721:
996:
989:
283:
2193:
1223:
1476:
1455:
1174:
1714:
1150:
2349:
1472:
205:
180:
49:
1451:
1948:
122:
1706:
319:
218:
1625:"Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden"
2464:
2334:
312:
211:
2450:
2437:
2424:
2411:
2398:
2385:
2372:
1863:
1848:
1748:
1168:
2344:
2298:
2241:
1745:
1679:
1061:
822:
130:
1155:
2246:
2138:
2103:
1345:
1278:
803:
1348:
plays a more minor role in the first step of insulin biosynthesis, but a greater role in the first step of
1235:
1143:
2267:
2186:
2093:
1943:
2339:
1078:
2083:
1294:
194:
1340:
Proprotein convertase 1 is the enzyme largely responsible for the first step in the biosynthesis of
1171:
109:
2303:
1983:
1973:
1790:
1785:
1675:
1364:
1330:
1314:
1282:
1095:
1073:
951:
900:
892:
2499:
2236:
154:
972:
947:
921:
896:
113:, BMIQ12, NEC1, PC1, PC3, SPC3, proprotein convertase subtilisin/kexin type 1, PC1/3, PCSK1 gene
1565:
1965:
1686:
1654:
1587:
1543:
1162:
102:
42:
2282:
2277:
2251:
2179:
1757:
1644:
1636:
1605:
1577:
1535:
1334:
1131:
399:
330:
274:
229:
150:
2329:
2313:
2226:
1998:
1993:
1765:
1741:
1107:
374:
1066:
2478:
2367:
2308:
1649:
1624:
1206:
1186:
692:
687:
682:
677:
672:
656:
651:
646:
641:
636:
631:
615:
610:
605:
600:
595:
590:
2488:
2272:
2231:
2143:
2016:
2005:
1737:
1695:
1539:
1353:
1313:
to their intermediate (or sometimes completely cleaved) forms. It is present only in
1181:
577:
2221:
2039:
1933:
1775:
392:
171:
134:
158:
2445:
2380:
2216:
2158:
2153:
1802:
1512:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1494:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1306:
1290:
1190:
2473:
475:
2120:
2062:
1843:
1838:
1818:
1368:
1286:
291:
188:
138:
1582:
2419:
2393:
2148:
2134:
1953:
1833:
1823:
1322:
722:
535:
413:
358:
345:
257:
244:
146:
1658:
1591:
1547:
1036:
1031:
25:
2034:
2029:
1978:
1828:
1813:
1780:
1640:
1403:
1349:
1119:
1020:
867:
848:
2088:
2078:
2024:
1938:
1770:
1700:
1690:
1415:
1341:
1326:
1310:
1138:
834:
789:
79:
75:
71:
2432:
2202:
2115:
2057:
1396:
1267:
1218:
1114:
1102:
1090:
1004:
744:
2406:
2124:
2110:
2049:
1923:
1918:
1913:
1908:
1903:
1898:
1392:
1388:
1384:
1380:
1376:
1372:
1357:
1318:
707:
703:
1893:
1888:
1883:
1878:
1873:
1868:
1858:
1853:
1274:
1126:
126:
2175:
1710:
1564:
Jansen E, Ayoubi TA, Meulemans SM, Van de Ven WJ (June 1995).
1685:
Overview of all the structural information available in the
1623:
Renström F, Payne F, Nordström A, et al. (April 2009).
2171:
382:
1428:
Proprotein convertase subtilisin/kexin type 1 inhibitor
2462:
547:
1363:
Proprotein convertase 1 is a calcium (Ca) activated
2358:
2322:
2291:
2260:
2209:
2071:
2048:
2014:
1964:
1801:
1756:
1229:
1217:
1205:
1200:
1180:
1161:
1149:
1137:
1125:
1113:
1101:
1089:
1084:
1072:
1060:
1055:
1050:
965:
940:
914:
885:
502:
dentate gyrus of hippocampal formation granule cell
1468:
1466:
1464:
1447:
1445:
1443:
1414:Variants in the PCSK1 gene may be associated with
329:
228:
1329:, and most often cleaves after a pair of basic
1473:GRCm38: Ensembl release 89: ENSMUSG00000021587
2187:
1722:
1559:
1557:
8:
1356:of proprotein convertase 1 is not lethal in
1699:(Mouse Neuroendocrine convertase 1) at the
1452:GRCh38: Ensembl release 89: ENSG00000175426
2194:
2180:
2172:
1729:
1715:
1707:
1197:
718:
573:
370:
269:
166:
60:
1678:at the U.S. National Library of Medicine
1648:
1581:
2469:
1439:
506:paraventricular nucleus of hypothalamus
1742:serine proteases/serine endopeptidases
1047:
15:
1305:PC1/3 is an enzyme that performs the
334:
295:
290:
233:
192:
187:
7:
962:
937:
911:
882:
858:
839:
813:
794:
768:
749:
611:serine-type endopeptidase activity
552:
522:central gray substance of midbrain
470:
408:
387:
14:
1402:Proprotein convertase 1 converts
1285:and they act together to process
1270:that in humans is encoded by the
2472:
494:pars distalis of adenohypophysis
318:
311:
305:
282:
217:
210:
204:
179:
24:
596:serine-type peptidase activity
536:More reference expression data
1:
1954:Urinary plasminogen activator
303:
202:
1949:Tissue plasminogen activator
1540:10.1016/0888-7543(91)90106-O
673:peptide biosynthetic process
2495:Genes on human chromosome 5
1260:neuroendocrine convertase 1
2516:
683:peptide hormone processing
2350:Michaelis–Menten kinetics
2040:Proteinase 3/Myeloblastin
1508:"Mouse PubMed Reference:"
1490:"Human PubMed Reference:"
1262:and often abbreviated as
1196:
1035:
1030:
1026:
1019:
1003:
984:
969:
944:
933:
918:
889:
878:
865:
861:
846:
842:
833:
820:
816:
801:
797:
788:
775:
771:
756:
752:
743:
728:
721:
717:
701:
616:identical protein binding
576:
572:
560:
555:
546:
533:
482:
473:
420:
411:
381:
373:
369:
352:
339:
302:
281:
272:
268:
251:
238:
201:
178:
169:
165:
120:
117:
107:
100:
95:
68:
63:
46:
41:
36:
32:
23:
18:
2242:Diffusion-limited enzyme
1680:Medical Subject Headings
1583:10.1074/jbc.270.25.15391
997:Chr 13: 75.24 – 75.28 Mb
1676:Proprotein+Convertase+1
1346:proprotein convertase 2
1256:prohormone convertase 3
1248:Proprotein convertase 1
1051:proprotein convertase 1
990:Chr 5: 96.39 – 96.43 Mb
632:secretory granule lumen
2094:Proprotein convertases
1281:differentially cleave
601:endopeptidase activity
514:superior frontal gyrus
498:lumbar spinal ganglion
432:superior frontal gyrus
336:13 C1|13 40.63 cM
2335:Eadie–Hofstee diagram
2268:Allosteric regulation
1944:Plasminogen activator
1410:Clinical significance
1252:prohormone convertase
510:primary visual cortex
456:primary visual cortex
297:Chromosome 13 (mouse)
2345:Lineweaver–Burk plot
2084:Prolyl endopeptidase
1315:neuroendocrine cells
1307:proteolytic cleavage
436:orbitofrontal cortex
195:Chromosome 5 (human)
64:List of PDB id codes
37:Available structures
1365:serine endoprotease
1283:proopiomelanocortin
678:cell-cell signaling
647:extracellular space
642:cytoplasmic vesicle
490:islet of Langerhans
2304:Enzyme superfamily
2237:Enzyme promiscuity
1641:10.1093/hmg/ddp041
1352:biosynthesis. The
823:ENSMUSG00000021587
693:protein processing
666:Biological process
625:Cellular component
606:hydrolase activity
591:peptidase activity
584:Molecular function
486:supraoptic nucleus
2460:
2459:
2169:
2168:
1966:Complement system
1758:Digestive enzymes
1295:pancreatic islets
1245:
1244:
1241:
1240:
1144:metabolic pathway
1046:
1045:
1042:
1041:
1015:
1014:
980:
979:
959:
958:
929:
928:
908:
907:
874:
873:
855:
854:
829:
828:
810:
809:
784:
783:
765:
764:
713:
712:
657:neuron projection
637:transport vesicle
568:
567:
564:
563:
542:
541:
529:
528:
467:
466:
428:postcentral gyrus
365:
364:
264:
263:
159:PCSK1 - orthologs
91:
90:
87:
86:
47:Ortholog search:
2507:
2477:
2476:
2468:
2340:Hanes–Woolf plot
2283:Enzyme activator
2278:Enzyme inhibitor
2252:Enzyme catalysis
2196:
2189:
2182:
2173:
1731:
1724:
1717:
1708:
1663:
1662:
1652:
1620:
1614:
1613:
1602:
1596:
1595:
1585:
1561:
1552:
1551:
1522:
1516:
1515:
1504:
1498:
1497:
1486:
1480:
1470:
1459:
1449:
1250:, also known as
1198:
1048:
1028:
1027:
999:
992:
975:
963:
954:
938:
934:RefSeq (protein)
924:
912:
903:
883:
859:
840:
814:
795:
769:
750:
719:
574:
553:
538:
478:
476:Top expressed in
471:
452:Brodmann area 10
448:endothelial cell
444:Brodmann area 46
440:Brodmann area 23
416:
414:Top expressed in
409:
388:
371:
361:
348:
337:
322:
315:
309:
298:
286:
270:
260:
247:
236:
221:
214:
208:
197:
183:
167:
161:
112:
105:
82:
61:
55:
34:
33:
28:
16:
2515:
2514:
2510:
2509:
2508:
2506:
2505:
2504:
2485:
2484:
2483:
2471:
2463:
2461:
2456:
2368:Oxidoreductases
2354:
2330:Enzyme kinetics
2318:
2314:List of enzymes
2287:
2256:
2227:Catalytic triad
2205:
2200:
2170:
2165:
2067:
2044:
2010:
1960:
1797:
1766:Enteropeptidase
1752:
1735:
1672:
1667:
1666:
1629:Hum. Mol. Genet
1622:
1621:
1617:
1604:
1603:
1599:
1576:(25): 15391–7.
1563:
1562:
1555:
1524:
1523:
1519:
1506:
1505:
1501:
1488:
1487:
1483:
1471:
1462:
1450:
1441:
1436:
1424:
1412:
1303:
1037:View/Edit Mouse
1032:View/Edit Human
995:
988:
985:Location (UCSC)
971:
950:
946:
920:
899:
895:
891:
804:ENSG00000175426
697:
661:
620:
534:
525:
520:
518:arcuate nucleus
516:
512:
508:
504:
500:
496:
492:
488:
474:
463:
458:
454:
450:
446:
442:
438:
434:
430:
426:
412:
356:
343:
335:
325:
324:
323:
316:
296:
273:Gene location (
255:
242:
234:
224:
223:
222:
215:
193:
170:Gene location (
121:
108:
101:
70:
48:
12:
11:
5:
2513:
2511:
2503:
2502:
2497:
2487:
2486:
2482:
2481:
2458:
2457:
2455:
2454:
2441:
2428:
2415:
2402:
2389:
2376:
2362:
2360:
2356:
2355:
2353:
2352:
2347:
2342:
2337:
2332:
2326:
2324:
2320:
2319:
2317:
2316:
2311:
2306:
2301:
2295:
2293:
2292:Classification
2289:
2288:
2286:
2285:
2280:
2275:
2270:
2264:
2262:
2258:
2257:
2255:
2254:
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2213:
2211:
2207:
2206:
2201:
2199:
2198:
2191:
2184:
2176:
2167:
2166:
2164:
2163:
2162:
2161:
2156:
2146:
2141:
2132:
2118:
2113:
2108:
2107:
2106:
2101:
2091:
2086:
2081:
2075:
2073:
2069:
2068:
2066:
2065:
2060:
2054:
2052:
2046:
2045:
2043:
2042:
2037:
2032:
2027:
2021:
2019:
2012:
2011:
2009:
2008:
2003:
2002:
2001:
1996:
1986:
1981:
1976:
1970:
1968:
1962:
1961:
1959:
1958:
1957:
1956:
1951:
1941:
1929:
1928:
1927:
1926:
1921:
1916:
1911:
1906:
1901:
1896:
1891:
1886:
1881:
1876:
1871:
1866:
1861:
1856:
1851:
1841:
1836:
1831:
1826:
1821:
1816:
1807:
1805:
1799:
1798:
1796:
1795:
1794:
1793:
1788:
1778:
1773:
1768:
1762:
1760:
1754:
1753:
1738:Endopeptidases
1736:
1734:
1733:
1726:
1719:
1711:
1705:
1704:
1683:
1671:
1670:External links
1668:
1665:
1664:
1635:(8): 1489–96.
1615:
1610:www.qmul.ac.uk
1606:"EC 3.4.21.93"
1597:
1553:
1517:
1499:
1481:
1460:
1438:
1437:
1435:
1432:
1431:
1430:
1423:
1420:
1411:
1408:
1302:
1299:
1243:
1242:
1239:
1238:
1233:
1227:
1226:
1221:
1215:
1214:
1209:
1203:
1202:
1194:
1193:
1184:
1178:
1177:
1166:
1159:
1158:
1153:
1147:
1146:
1141:
1135:
1134:
1129:
1123:
1122:
1117:
1111:
1110:
1105:
1099:
1098:
1093:
1087:
1086:
1082:
1081:
1076:
1070:
1069:
1064:
1058:
1057:
1053:
1052:
1044:
1043:
1040:
1039:
1034:
1024:
1023:
1017:
1016:
1013:
1012:
1010:
1008:
1001:
1000:
993:
986:
982:
981:
978:
977:
967:
966:
960:
957:
956:
942:
941:
935:
931:
930:
927:
926:
916:
915:
909:
906:
905:
887:
886:
880:
876:
875:
872:
871:
863:
862:
856:
853:
852:
844:
843:
837:
831:
830:
827:
826:
818:
817:
811:
808:
807:
799:
798:
792:
786:
785:
782:
781:
773:
772:
766:
763:
762:
754:
753:
747:
741:
740:
735:
730:
726:
725:
715:
714:
711:
710:
699:
698:
696:
695:
690:
685:
680:
675:
669:
667:
663:
662:
660:
659:
654:
649:
644:
639:
634:
628:
626:
622:
621:
619:
618:
613:
608:
603:
598:
593:
587:
585:
581:
580:
570:
569:
566:
565:
562:
561:
558:
557:
550:
544:
543:
540:
539:
531:
530:
527:
526:
524:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
483:
480:
479:
468:
465:
464:
462:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
418:
417:
405:
404:
396:
385:
379:
378:
375:RNA expression
367:
366:
363:
362:
354:
350:
349:
341:
338:
333:
327:
326:
317:
310:
304:
300:
299:
294:
288:
287:
279:
278:
266:
265:
262:
261:
253:
249:
248:
240:
237:
232:
226:
225:
216:
209:
203:
199:
198:
191:
185:
184:
176:
175:
163:
162:
119:
115:
114:
106:
98:
97:
93:
92:
89:
88:
85:
84:
66:
65:
57:
56:
45:
39:
38:
30:
29:
21:
20:
13:
10:
9:
6:
4:
3:
2:
2512:
2501:
2498:
2496:
2493:
2492:
2490:
2480:
2475:
2470:
2466:
2452:
2448:
2447:
2442:
2439:
2435:
2434:
2429:
2426:
2422:
2421:
2416:
2413:
2409:
2408:
2403:
2400:
2396:
2395:
2390:
2387:
2383:
2382:
2377:
2374:
2370:
2369:
2364:
2363:
2361:
2357:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2327:
2325:
2321:
2315:
2312:
2310:
2309:Enzyme family
2307:
2305:
2302:
2300:
2297:
2296:
2294:
2290:
2284:
2281:
2279:
2276:
2274:
2273:Cooperativity
2271:
2269:
2266:
2265:
2263:
2259:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2233:
2232:Oxyanion hole
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2214:
2212:
2208:
2204:
2197:
2192:
2190:
2185:
2183:
2178:
2177:
2174:
2160:
2157:
2155:
2152:
2151:
2150:
2147:
2145:
2144:Streptokinase
2142:
2140:
2136:
2133:
2130:
2126:
2122:
2119:
2117:
2114:
2112:
2109:
2105:
2102:
2100:
2097:
2096:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2076:
2074:
2070:
2064:
2061:
2059:
2056:
2055:
2053:
2051:
2047:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2022:
2020:
2018:
2017:immune system
2013:
2007:
2006:C3-convertase
2004:
2000:
1997:
1995:
1992:
1991:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1971:
1969:
1967:
1963:
1955:
1952:
1950:
1947:
1946:
1945:
1942:
1940:
1937:
1935:
1931:
1930:
1925:
1922:
1920:
1917:
1915:
1912:
1910:
1907:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1887:
1885:
1882:
1880:
1877:
1875:
1872:
1870:
1867:
1865:
1862:
1860:
1857:
1855:
1852:
1850:
1847:
1846:
1845:
1842:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1815:
1812:
1809:
1808:
1806:
1804:
1800:
1792:
1789:
1787:
1784:
1783:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1763:
1761:
1759:
1755:
1750:
1747:
1743:
1739:
1732:
1727:
1725:
1720:
1718:
1713:
1712:
1709:
1702:
1698:
1697:
1692:
1688:
1684:
1681:
1677:
1674:
1673:
1669:
1660:
1656:
1651:
1646:
1642:
1638:
1634:
1630:
1626:
1619:
1616:
1611:
1607:
1601:
1598:
1593:
1589:
1584:
1579:
1575:
1571:
1570:J. Biol. Chem
1567:
1560:
1558:
1554:
1549:
1545:
1541:
1537:
1533:
1529:
1521:
1518:
1513:
1509:
1503:
1500:
1495:
1491:
1485:
1482:
1478:
1474:
1469:
1467:
1465:
1461:
1457:
1453:
1448:
1446:
1444:
1440:
1433:
1429:
1426:
1425:
1421:
1419:
1417:
1409:
1407:
1405:
1400:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1361:
1359:
1355:
1351:
1347:
1343:
1338:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1300:
1298:
1296:
1292:
1288:
1284:
1280:
1276:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1237:
1234:
1232:
1228:
1225:
1222:
1220:
1216:
1213:
1210:
1208:
1204:
1199:
1195:
1192:
1188:
1185:
1183:
1182:Gene Ontology
1179:
1176:
1173:
1170:
1167:
1164:
1160:
1157:
1154:
1152:
1148:
1145:
1142:
1140:
1136:
1133:
1130:
1128:
1124:
1121:
1120:NiceZyme view
1118:
1116:
1112:
1109:
1106:
1104:
1100:
1097:
1094:
1092:
1088:
1083:
1080:
1077:
1075:
1071:
1068:
1065:
1063:
1059:
1054:
1049:
1038:
1033:
1029:
1025:
1022:
1018:
1011:
1009:
1006:
1002:
998:
994:
991:
987:
983:
976:
974:
968:
964:
961:
955:
953:
949:
943:
939:
936:
932:
925:
923:
917:
913:
910:
904:
902:
898:
894:
888:
884:
881:
879:RefSeq (mRNA)
877:
870:
869:
864:
860:
857:
851:
850:
845:
841:
838:
836:
832:
825:
824:
819:
815:
812:
806:
805:
800:
796:
793:
791:
787:
780:
779:
774:
770:
767:
761:
760:
755:
751:
748:
746:
742:
739:
736:
734:
731:
727:
724:
720:
716:
709:
705:
700:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
670:
668:
665:
664:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
629:
627:
624:
623:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
588:
586:
583:
582:
579:
578:Gene ontology
575:
571:
559:
554:
551:
549:
545:
537:
532:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
484:
481:
477:
472:
469:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
422:
419:
415:
410:
407:
406:
403:
401:
397:
395:
394:
390:
389:
386:
384:
380:
376:
372:
368:
360:
355:
351:
347:
342:
332:
328:
321:
314:
308:
301:
293:
289:
285:
280:
276:
271:
267:
259:
254:
250:
246:
241:
231:
227:
220:
213:
207:
200:
196:
190:
186:
182:
177:
173:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
116:
111:
104:
99:
94:
83:
81:
77:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
17:
2446:Translocases
2443:
2430:
2417:
2404:
2391:
2381:Transferases
2378:
2365:
2222:Binding site
2098:
1934:fibrinolysis
1932:
1810:
1776:Chymotrypsin
1694:
1632:
1628:
1618:
1609:
1600:
1573:
1569:
1534:(1): 103–7.
1531:
1527:
1520:
1511:
1502:
1493:
1484:
1413:
1406:into renin.
1401:
1362:
1339:
1304:
1277:. PCSK1 and
1271:
1263:
1259:
1255:
1251:
1247:
1246:
1108:BRENDA entry
970:
952:NP_001171346
945:
919:
901:NM_001177875
893:NM_001177876
890:
866:
847:
821:
802:
776:
757:
737:
732:
398:
391:
118:External IDs
69:
2217:Active site
1839:Factor XIIa
1819:Factor VIIa
1803:Coagulation
1291:proglucagon
1096:IntEnz view
1079:99676-46-7
1056:Identifiers
688:proteolysis
357:75,282,980
344:75,237,945
256:96,434,143
243:96,390,333
96:Identifiers
2489:Categories
2420:Isomerases
2394:Hydrolases
2261:Regulation
2121:Subtilisin
2063:Batroxobin
1844:Kallikrein
1834:Factor XIa
1824:Factor IXa
1791:Pancreatic
1786:Neutrophil
1479:, May 2017
1458:, May 2017
1434:References
1369:subtilisin
1287:proinsulin
1165:structures
1132:KEGG entry
402:(ortholog)
139:HomoloGene
2500:EC 3.4.21
2299:EC number
2149:Cathepsin
2135:Sedolisin
2111:Prostasin
1829:Factor Xa
1323:pituitary
1085:Databases
1067:3.4.21.93
973:NP_038656
948:NP_000430
922:NM_013628
897:NM_000439
723:Orthologs
424:beta cell
147:GeneCards
2323:Kinetics
2247:Cofactor
2210:Activity
2050:Venombin
2035:Tryptase
2030:Granzyme
1984:Factor I
1979:Factor D
1974:Factor B
1814:Thrombin
1811:factors:
1781:Elastase
1659:19164386
1528:Genomics
1475:–
1454:–
1422:See also
1404:prorenin
1397:SKI1/S1P
1354:knockout
1350:glucagon
1331:residues
1317:such as
1311:hormones
1301:Function
1236:proteins
1224:articles
1212:articles
1169:RCSB PDB
1021:Wikidata
702:Sources:
652:membrane
460:testicle
2479:Biology
2433:Ligases
2203:Enzymes
2089:Pronase
2079:Acrosin
2025:Chymase
1939:Plasmin
1771:Trypsin
1701:PDBe-KB
1691:UniProt
1650:2664142
1592:7797529
1548:1765368
1477:Ensembl
1456:Ensembl
1416:obesity
1342:insulin
1327:adrenal
1191:QuickGO
1156:profile
1139:MetaCyc
1074:CAS no.
835:UniProt
790:Ensembl
729:Species
708:QuickGO
377:pattern
103:Aliases
2465:Portal
2407:Lyases
2116:Reelin
2058:Ancrod
2015:Other
1749:3.4.21
1696:P63239
1682:(MeSH)
1657:
1647:
1590:
1546:
1395:, and
1309:of pro
1268:enzyme
1266:is an
1219:PubMed
1201:Search
1187:AmiGO
1175:PDBsum
1115:ExPASy
1103:BRENDA
1091:IntEnz
1062:EC no.
1007:search
1005:PubMed
868:P63239
849:P29120
745:Entrez
548:BioGPS
127:162150
2359:Types
2125:Furin
2072:Other
1999:MASP2
1994:MASP1
1924:KLK15
1919:KLK14
1914:KLK13
1909:KLK12
1904:KLK11
1899:KLK10
1393:PCSK9
1389:PC7/8
1385:PC5/6
1377:PACE4
1373:furin
1319:brain
1279:PCSK2
1272:PCSK1
1264:PC1/3
1258:, or
1151:PRIAM
778:18548
738:Mouse
733:Human
704:Amigo
400:Mouse
393:Human
340:Start
275:Mouse
239:Start
172:Human
151:PCSK1
135:97511
110:PCSK1
19:PCSK1
2451:list
2444:EC7
2438:list
2431:EC6
2425:list
2418:EC5
2412:list
2405:EC4
2399:list
2392:EC3
2386:list
2379:EC2
2373:list
2366:EC1
2139:TPP1
1989:MASP
1894:KLK9
1889:KLK8
1884:KLK7
1879:KLK6
1874:KLK5
1869:KLK4
1864:KLK3
1859:KLK2
1854:KLK1
1689:for
1655:PMID
1588:PMID
1544:PMID
1358:mice
1325:and
1289:and
1275:gene
1231:NCBI
1172:PDBe
1127:KEGG
759:5122
383:Bgee
331:Band
292:Chr.
235:5q15
230:Band
189:Chr.
123:OMIM
80:2KE3
76:2KDT
72:1KN6
53:RCSB
50:PDBe
2129:S1P
1849:PSA
1687:PDB
1645:PMC
1637:doi
1578:doi
1574:270
1536:doi
1381:PC4
1335:kDa
1293:in
1207:PMC
1163:PDB
556:n/a
353:End
252:End
155:OMA
143:379
131:MGI
43:PDB
2491::
1746:EC
1740::
1693::
1653:.
1643:.
1633:18
1631:.
1627:.
1608:.
1586:.
1572:.
1568:.
1556:^
1542:.
1532:11
1530:.
1510:.
1492:.
1463:^
1442:^
1418:.
1399:.
1391:,
1387:,
1383:,
1379:,
1375:,
1321:,
1297:.
1254:,
1189:/
706:/
359:bp
346:bp
258:bp
245:bp
153:;
149::
145:;
141::
137:;
133::
129:;
125::
78:,
74:,
2467::
2453:)
2449:(
2440:)
2436:(
2427:)
2423:(
2414:)
2410:(
2401:)
2397:(
2388:)
2384:(
2375:)
2371:(
2195:e
2188:t
2181:v
2159:G
2154:A
2137:/
2131:4
2127:/
2123:/
2104:2
2099:1
1936::
1751:)
1744:(
1730:e
1723:t
1716:v
1703:.
1661:.
1639::
1612:.
1594:.
1580::
1550:.
1538::
1514:.
1496:.
277:)
174:)
157::
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