253:
230:
127:
152:
504:
259:
158:
3290:
1052:
This glucocorticoid-inactivating enzyme is also expressed in tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, as well as parts of the developing brain, including the rhombencephalic progenitor cells that proliferate into cerebellar
1049:. This protective mechanism is necessary because cortisol circulates at 100- to 1000-fold higher concentrations than aldosterone, and binds with equal affinity to the mineralocorticoid receptor, thereby out-competing aldosterone in cells that do not produce HSD11B2.
1971:
1603:
Wilson RC, Harbison MD, Krozowski ZS, et al. (1995). "Several homozygous mutations in the gene for 11 beta-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess".
1727:
Agarwal AK, Rogerson FM, Mune T, White PC (1996). "Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase".
1756:
Krozowski Z, Albiston AL, Obeyesekere VR, et al. (1996). "The human 11 beta-hydroxysteroid dehydrogenase type II enzyme: comparisons with other species and localization to the distal nephron".
2768:
1964:
2763:
1957:
1661:
Krozowski Z, Baker E, Obeyesekere V, Callen DF (1995). "Localization of the gene for human 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) to chromosome band 16q22".
2924:
266:
165:
2578:
1176:
Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (November 1994). "Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme".
1566:
Stewart PM, Wallace AM, Valentino R, et al. (1987). "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age".
1078:
1690:
Mune T, Rogerson FM, Nikkilä H, et al. (1995). "Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase".
2612:
1057:. In these tissues, HSD11B2 protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development.
2853:
2813:
2341:
2336:
731:
88:
712:
2698:
2167:
2641:
2113:
1219:
Brown RW, Chapman KE, Kotelevtsev Y, Yau JL, Lindsay RS, Brett L, Leckie C, Murad P, Lyons V, Mullins JJ, Edwards CR, Seckl JR (February 1996).
2753:
2531:
2281:
3310:
2571:
1838:"A new compound heterozygous mutation in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess"
1158:
1140:
2848:
2808:
2050:
1949:
1529:
Funder JW, Pearce PT, Smith R, Smith AI (1988). "Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated".
2858:
2825:
2469:
2425:
2328:
2108:
1632:
Wilson RC, Krozowski ZS, Li K, et al. (1995). "A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess".
252:
2952:
2713:
2626:
2417:
2353:
938:
931:
3009:
2708:
2608:
229:
2564:
1268:
1795:"Purification of 11 beta-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique"
2621:
2225:
2055:
1127:
1106:
2947:
2773:
2206:
1022:-selective epithelial tissues such as the kidney, colon, salivary and sweat glands. HSD211B2 expression is also found in the
151:
126:
3165:
1123:
2758:
2541:
2248:
2196:
2129:
1027:
1102:
2786:
68:
265:
164:
2919:
2683:
2536:
2090:
258:
157:
3280:
2688:
1046:
59:, AME, AME1, HSD11K, HSD2, SDR9C3, hydroxysteroid (11-beta) dehydrogenase 2, hydroxysteroid 11-beta dehydrogenase 2
3150:
3266:
3253:
3240:
3227:
3214:
3201:
3188:
2962:
2934:
2906:
2868:
2835:
2738:
2604:
2201:
3160:
3114:
3057:
2728:
2595:
2103:
1074:
776:
76:
3062:
2886:
2693:
757:
1873:"Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess"
2778:
2591:
2172:
3083:
3002:
2971:
2733:
2631:
2134:
140:
3155:
2748:
2743:
2703:
2306:
2187:
1538:
1384:
2556:
1461:"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response"
55:
3119:
2636:
2177:
1221:"Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2"
1066:
3052:
2492:
2008:
2000:
1781:
1715:
1591:
1201:
100:
2378:
1908:"Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess"
1003:
914:
893:
867:
846:
3315:
2723:
2718:
2503:
2433:
2098:
2079:
1937:
1894:
1859:
1824:
1773:
1744:
1707:
1678:
1649:
1620:
1583:
1554:
1517:
1482:
1447:
1412:
1359:
1313:
1250:
1193:
1070:
503:
48:
96:
3098:
3093:
3067:
2995:
2891:
2678:
2511:
2031:
1984:
1927:
1919:
1884:
1849:
1814:
1806:
1765:
1736:
1699:
1670:
1641:
1612:
1575:
1546:
1507:
1472:
1437:
1402:
1392:
1349:
1338:"11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess"
1303:
1295:
1240:
1232:
1185:
345:
276:
220:
175:
3145:
3129:
3042:
2896:
2881:
2263:
320:
1542:
1388:
3294:
3183:
3124:
2587:
2373:
2292:
2071:
1932:
1907:
1819:
1794:
1308:
1283:
1245:
1220:
1579:
646:
641:
636:
631:
626:
621:
616:
611:
606:
590:
585:
580:
575:
560:
555:
550:
545:
3304:
3088:
3047:
1769:
1512:
1495:
1407:
1372:
1189:
1054:
532:
1785:
1719:
1595:
1018:
Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD-dependent enzyme expressed in
3037:
2273:
1205:
1031:
338:
117:
80:
104:
3261:
3196:
3032:
2389:
2301:
2216:
2149:
2060:
2042:
1992:
1299:
1163:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1145:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1019:
3289:
1616:
1077:. A genetically inherited deficiency of HSD11B2 is the underlying cause of the
421:
17:
2839:
2791:
2159:
1980:
1645:
237:
134:
84:
1397:
3235:
3209:
2910:
2497:
2464:
2318:
2240:
1854:
1837:
1550:
1042:
1023:
676:
481:
359:
304:
291:
203:
190:
92:
2796:
1889:
1872:
1740:
1521:
1486:
1451:
1442:
1425:
1354:
1337:
1317:
1941:
1898:
1863:
1828:
1777:
1748:
1711:
1682:
1653:
1624:
1587:
1558:
1416:
1363:
1254:
1197:
978:
973:
2456:
2399:
2314:
2026:
1477:
1460:
1038:
962:
821:
802:
2938:
2651:
2522:
2517:
2412:
2407:
2323:
2253:
2018:
1996:
1703:
788:
743:
1810:
1674:
1236:
3248:
3018:
2976:
2872:
2671:
2666:
2661:
2656:
2646:
2443:
2438:
2366:
2361:
1988:
998:
946:
698:
1923:
1026:
in a small, aldosterone-sensitive subset of neurons located in the
3222:
2801:
661:
657:
1007:
72:
2991:
2560:
1953:
1269:"Entrez Gene: HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2"
512:
1496:"11beta-Hydroxysteroid deshydrogenase: a multi-faceted enzyme"
1073:, found in natural liquorice, results in a condition known as
2769:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1871:
Dave-Sharma S, Wilson RC, Harbison MD, et al. (1998).
1373:"A genetic defect resulting in mild low-renin hypertension"
2987:
1459:
Tomlinson JW, Walker EA, Bujalska IJ, et al. (2005).
328:
1065:
Inhibition of this enzyme, for example by the compound
1836:
Kitanaka S, Katsumata N, Tanae A, et al. (1998).
1371:
Wilson RC, Dave-Sharma S, Wei JQ, et al. (1998).
1037:
In these tissues, HSD11B2 oxidizes the glucocorticoid
3278:
1282:
Geerling, Joel C.; Arthur D. Loewy (September 2009).
493:
2471:
2427:
2419:
2355:
2330:
3174:
3138:
3107:
3076:
3025:
2961:
2933:
2905:
2867:
2834:
2764:
Malate dehydrogenase (oxaloacetate-decarboxylating)
2603:
2485:
2454:
2397:
2387:
2290:
2271:
2262:
2238:
2215:
2186:
2157:
2147:
2122:
2088:
2069:
2041:
2016:
2007:
1793:Brown RW, Chapman KE, Murad P, et al. (1996).
907:
886:
860:
839:
2925:Vitamin-K-epoxide reductase (warfarin-insensitive)
1119:
1117:
1115:
1098:
1096:
1094:
1906:Li A, Tedde R, Krozowski ZS, et al. (1998).
1426:"Hypertension and the cortisol-cortisone shuttle"
275:
174:
1288:American Journal of Physiology. Renal Physiology
642:regulation of blood volume by renal aldosterone
1124:GRCm38: Ensembl release 89: ENSMUSG00000031891
3003:
2572:
1965:
1079:syndrome of apparent mineralocorticoid excess
8:
1045:, thus preventing illicit activation of the
1103:GRCh38: Ensembl release 89: ENSG00000176387
991:Corticosteroid 11-β-dehydrogenase isozyme 2
3010:
2996:
2988:
2854:D-lactate dehydrogenase (cytochrome c-553)
2579:
2565:
2557:
2394:
2268:
2154:
2013:
1972:
1958:
1950:
672:
528:
316:
215:
112:
1931:
1888:
1853:
1818:
1511:
1476:
1441:
1406:
1396:
1353:
1307:
1244:
2699:D-malate dehydrogenase (decarboxylating)
2168:Farnesyl-diphosphate farnesyltransferase
586:intracellular membrane-bounded organelle
3285:
2114:Isopentenyl-diphosphate delta isomerase
1090:
2754:Malate dehydrogenase (decarboxylating)
2532:Steroidogenic acute regulatory protein
29:
1336:White PC, Mune T, Agarwal AK (1997).
561:11-beta-hydroxysteroid dehydrogenase
280:
241:
236:
179:
138:
133:
7:
2849:D-lactate dehydrogenase (cytochrome)
2859:Mannitol dehydrogenase (cytochrome)
2109:Pyrophosphomevalonate decarboxylase
2027:Acetyl-Coenzyme A acetyltransferase
995:11-β-hydroxysteroid dehydrogenase 2
637:glucocorticoid biosynthetic process
2953:Quinoprotein glucose dehydrogenase
2714:Glycerol-3-phosphate dehydrogenase
2627:3-hydroxybutyryl-CoA dehydrogenase
904:
883:
857:
836:
812:
793:
767:
748:
722:
703:
498:
416:
354:
333:
25:
2709:Glucose-6-phosphate dehydrogenase
1001:that in humans is encoded by the
3288:
1513:10.1097/00004872-200501000-00007
612:glucocorticoid metabolic process
502:
264:
257:
251:
228:
163:
156:
150:
125:
2622:3-hydroxyacyl-CoA dehydrogenase
2282:Cholesterol side-chain cleavage
2226:24-Dehydrocholesterol reductase
2056:3-hydroxybutyrate dehydrogenase
1424:Quinkler M, Stewart PM (2003).
2948:Malate dehydrogenase (quinone)
2774:Phosphogluconate dehydrogenase
2207:7-Dehydrocholesterol reductase
581:endoplasmic reticulum membrane
513:More reference expression data
482:More reference expression data
1:
2542:Reverse cholesterol transport
2130:Dimethylallyltranstransferase
1758:J. Steroid Biochem. Mol. Biol
1580:10.1016/S0140-6736(87)91014-2
1069:enzymatically converted from
1028:nucleus of the solitary tract
249:
148:
3311:Genes on human chromosome 16
2787:Hydroxysteroid dehydrogenase
2759:Malate dehydrogenase (NADP+)
1770:10.1016/0960-0760(95)00194-8
1377:Proc. Natl. Acad. Sci. U.S.A
1190:10.1016/0303-7207(94)90176-7
2920:Vitamin K epoxide reductase
2689:Carbohydrate dehydrogenases
2684:Beta-Ketoacyl ACP reductase
2537:Cholesterol total synthesis
1300:10.1152/ajprenal.90399.2008
1041:to the inactive metabolite
622:response to steroid hormone
3332:
2249:Cholesterol 7α-hydroxylase
2197:Lanosterol 14α-demethylase
1877:J. Clin. Endocrinol. Metab
1842:J. Clin. Endocrinol. Metab
1634:J. Clin. Endocrinol. Metab
1617:10.1210/jcem.80.11.7593417
1605:J. Clin. Endocrinol. Metab
1430:J. Clin. Endocrinol. Metab
1284:"Aldosterone in the brain"
1047:mineralocorticoid receptor
627:response to glucocorticoid
370:mucosa of transverse colon
3166:Michaelis–Menten kinetics
2739:L-threonine dehydrogenase
2202:Sterol-C5-desaturase-like
1646:10.1210/jcem.80.7.7608290
1159:"Mouse PubMed Reference:"
1141:"Human PubMed Reference:"
977:
972:
968:
961:
945:
939:Chr 8: 106.25 – 106.25 Mb
926:
911:
890:
879:
864:
843:
832:
819:
815:
800:
796:
787:
774:
770:
755:
751:
742:
729:
725:
710:
706:
697:
682:
675:
671:
655:
531:
527:
510:
501:
492:
479:
428:
419:
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
3058:Diffusion-limited enzyme
2729:Isocitrate dehydrogenase
2104:Phosphomevalonate kinase
1398:10.1073/pnas.95.17.10200
1075:pseudohyperaldosteronism
932:Chr 16: 67.43 – 67.44 Mb
2887:L-gulonolactone oxidase
2694:Carnitine dehydrogenase
2592:alcohol oxidoreductases
1855:10.1210/jcem.82.12.4455
1551:10.1126/science.2845584
556:oxidoreductase activity
398:mucosa of sigmoid colon
2779:Sorbitol dehydrogenase
2173:Squalene monooxygenase
1890:10.1210/jcem.83.7.4986
1741:10.1006/geno.1995.1231
1443:10.1210/jc.2003-030138
1355:10.1210/edrv.18.1.0288
27:Enzyme found in humans
3151:Eadie–Hofstee diagram
3084:Allosteric regulation
2972:Choline dehydrogenase
2734:Lactate dehydrogenase
2632:Alcohol dehydrogenase
2254:Sterol 27-hydroxylase
2135:Geranyl pyrophosphate
1663:Cytogenet. Cell Genet
1178:Mol. Cell. Endocrinol
1061:Clinical significance
591:endoplasmic reticulum
406:minor salivary glands
141:Chromosome 16 (human)
3161:Lineweaver–Burk plot
2749:Malate dehydrogenase
2744:L-xylulose reductase
2704:DXP reductoisomerase
2188:7-Dehydrocholesterol
1478:10.1210/er.2003-0031
282:8 D3|8 53.04 cM
243:Chromosome 8 (mouse)
2637:Aldo-keto reductase
2178:Lanosterol synthase
1543:1988Sci...242..583F
1389:1998PNAS...9510200W
1067:glycyrrhetinic acid
632:response to insulin
607:response to hypoxia
105:HSD11B2 - orthologs
3120:Enzyme superfamily
3053:Enzyme promiscuity
2493:Steroid metabolism
2009:Mevalonate pathway
2001:steroid metabolism
1805:(Pt 3): 997–1005.
1704:10.1038/ng0895-394
777:ENSMUSG00000031891
600:Biological process
569:Cellular component
539:Molecular function
3276:
3275:
2985:
2984:
2965:: other acceptors
2941:/similar acceptor
2724:IMP dehydrogenase
2719:HMG-CoA reductase
2554:
2553:
2550:
2549:
2504:Steroid sulfatase
2481:
2480:
2234:
2233:
2143:
2142:
2099:Mevalonate kinase
2080:HMG-CoA reductase
1912:Am. J. Hum. Genet
1811:10.1042/bj3130997
1675:10.1159/000134089
1237:10.1042/bj3131007
1231:(Pt 3): 1007–17.
1071:glycyrrhizic acid
988:
987:
984:
983:
957:
956:
922:
921:
901:
900:
875:
874:
854:
853:
828:
827:
809:
808:
783:
782:
764:
763:
738:
737:
719:
718:
667:
666:
523:
522:
519:
518:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
16:(Redirected from
3323:
3293:
3292:
3284:
3156:Hanes–Woolf plot
3099:Enzyme activator
3094:Enzyme inhibitor
3068:Enzyme catalysis
3012:
3005:
2998:
2989:
2892:Xanthine oxidase
2679:Aldose reductase
2581:
2574:
2567:
2558:
2512:sulfotransferase
2473:
2429:
2421:
2395:
2357:
2332:
2269:
2155:
2034:(regulated step)
2032:HMG-CoA synthase
2014:
1985:lipid metabolism
1974:
1967:
1960:
1951:
1945:
1935:
1902:
1892:
1867:
1857:
1832:
1822:
1789:
1752:
1723:
1686:
1657:
1628:
1599:
1562:
1525:
1515:
1494:Persu A (2005).
1490:
1480:
1455:
1445:
1420:
1410:
1400:
1367:
1357:
1322:
1321:
1311:
1279:
1273:
1272:
1265:
1259:
1258:
1248:
1216:
1210:
1209:
1173:
1167:
1166:
1155:
1149:
1148:
1137:
1131:
1121:
1110:
1100:
970:
969:
941:
934:
917:
905:
896:
884:
880:RefSeq (protein)
870:
858:
849:
837:
813:
794:
768:
749:
723:
704:
673:
647:response to food
617:female pregnancy
529:
515:
506:
499:
484:
424:
422:Top expressed in
417:
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
3331:
3330:
3326:
3325:
3324:
3322:
3321:
3320:
3301:
3300:
3299:
3287:
3279:
3277:
3272:
3184:Oxidoreductases
3170:
3146:Enzyme kinetics
3134:
3130:List of enzymes
3103:
3072:
3043:Catalytic triad
3021:
3016:
2986:
2981:
2957:
2929:
2901:
2897:Alcohol oxidase
2882:Glucose oxidase
2863:
2830:
2599:
2588:Oxidoreductases
2585:
2555:
2546:
2486:Other/ungrouped
2477:
2450:
2408:17α-Hydroxylase
2383:
2379:11β-Hydroxylase
2324:17α-Hydroxylase
2293:corticosteroids
2286:
2264:Steroidogenesis
2258:
2230:
2211:
2182:
2139:
2118:
2084:
2065:
2037:
2003:
1978:
1948:
1905:
1870:
1835:
1792:
1764:(5–6): 457–64.
1755:
1726:
1689:
1660:
1631:
1611:(11): 3145–50.
1602:
1574:(8563): 821–4.
1565:
1537:(4878): 583–5.
1528:
1493:
1458:
1423:
1383:(17): 10200–5.
1370:
1335:
1331:
1329:Further reading
1326:
1325:
1281:
1280:
1276:
1267:
1266:
1262:
1218:
1217:
1213:
1175:
1174:
1170:
1157:
1156:
1152:
1139:
1138:
1134:
1122:
1113:
1101:
1092:
1087:
1063:
1030:referred to as
1016:
979:View/Edit Mouse
974:View/Edit Human
937:
930:
927:Location (UCSC)
913:
892:
866:
845:
758:ENSG00000176387
651:
595:
564:
551:steroid binding
511:
480:
471:
466:
462:
458:
454:
450:
446:
442:
438:
434:
420:
409:
404:
402:skin of abdomen
400:
396:
392:
388:
386:mucosa of ileum
384:
380:
376:
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
18:Protein:HSD11B2
15:
12:
11:
5:
3329:
3327:
3319:
3318:
3313:
3303:
3302:
3298:
3297:
3274:
3273:
3271:
3270:
3257:
3244:
3231:
3218:
3205:
3192:
3178:
3176:
3172:
3171:
3169:
3168:
3163:
3158:
3153:
3148:
3142:
3140:
3136:
3135:
3133:
3132:
3127:
3122:
3117:
3111:
3109:
3108:Classification
3105:
3104:
3102:
3101:
3096:
3091:
3086:
3080:
3078:
3074:
3073:
3071:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3029:
3027:
3023:
3022:
3017:
3015:
3014:
3007:
3000:
2992:
2983:
2982:
2980:
2979:
2974:
2968:
2966:
2959:
2958:
2956:
2955:
2950:
2944:
2942:
2931:
2930:
2928:
2927:
2922:
2916:
2914:
2903:
2902:
2900:
2899:
2894:
2889:
2884:
2878:
2876:
2865:
2864:
2862:
2861:
2856:
2851:
2845:
2843:
2832:
2831:
2829:
2828:
2823:
2822:
2821:
2816:
2806:
2805:
2804:
2799:
2782:
2781:
2776:
2771:
2766:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2711:
2706:
2701:
2696:
2691:
2686:
2681:
2676:
2675:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2634:
2629:
2624:
2618:
2616:
2601:
2600:
2586:
2584:
2583:
2576:
2569:
2561:
2552:
2551:
2548:
2547:
2545:
2544:
2539:
2534:
2528:
2527:
2526:
2525:
2520:
2508:
2507:
2506:
2489:
2487:
2483:
2482:
2479:
2478:
2476:
2475:
2467:
2461:
2459:
2452:
2451:
2449:
2448:
2447:
2446:
2441:
2431:
2423:
2415:
2410:
2404:
2402:
2392:
2385:
2384:
2382:
2381:
2376:
2374:21-Hydroxylase
2371:
2370:
2369:
2364:
2347:
2346:
2345:
2344:
2339:
2326:
2310:
2309:
2307:18-Hydroxylase
2297:
2295:
2288:
2287:
2285:
2284:
2278:
2276:
2266:
2260:
2259:
2257:
2256:
2251:
2245:
2243:
2236:
2235:
2232:
2231:
2229:
2228:
2222:
2220:
2213:
2212:
2210:
2209:
2204:
2199:
2193:
2191:
2184:
2183:
2181:
2180:
2175:
2170:
2164:
2162:
2152:
2145:
2144:
2141:
2140:
2138:
2137:
2132:
2126:
2124:
2120:
2119:
2117:
2116:
2111:
2106:
2101:
2095:
2093:
2086:
2085:
2083:
2082:
2076:
2074:
2072:Mevalonic acid
2067:
2066:
2064:
2063:
2058:
2053:
2047:
2045:
2039:
2038:
2036:
2035:
2029:
2023:
2021:
2011:
2005:
2004:
1979:
1977:
1976:
1969:
1962:
1954:
1947:
1946:
1924:10.1086/301955
1903:
1883:(7): 2244–54.
1868:
1848:(12): 4054–8.
1833:
1790:
1753:
1724:
1687:
1658:
1629:
1600:
1563:
1526:
1491:
1456:
1436:(6): 2384–92.
1421:
1368:
1332:
1330:
1327:
1324:
1323:
1294:(3): F559–76.
1274:
1260:
1211:
1168:
1150:
1132:
1111:
1089:
1088:
1086:
1083:
1062:
1059:
1015:
1012:
993:also known as
986:
985:
982:
981:
976:
966:
965:
959:
958:
955:
954:
952:
950:
943:
942:
935:
928:
924:
923:
920:
919:
909:
908:
902:
899:
898:
888:
887:
881:
877:
876:
873:
872:
862:
861:
855:
852:
851:
841:
840:
834:
830:
829:
826:
825:
817:
816:
810:
807:
806:
798:
797:
791:
785:
784:
781:
780:
772:
771:
765:
762:
761:
753:
752:
746:
740:
739:
736:
735:
727:
726:
720:
717:
716:
708:
707:
701:
695:
694:
689:
684:
680:
679:
669:
668:
665:
664:
653:
652:
650:
649:
644:
639:
634:
629:
624:
619:
614:
609:
603:
601:
597:
596:
594:
593:
588:
583:
578:
572:
570:
566:
565:
563:
562:
558:
553:
548:
542:
540:
536:
535:
525:
524:
521:
520:
517:
516:
508:
507:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
468:abdominal wall
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3328:
3317:
3314:
3312:
3309:
3308:
3306:
3296:
3291:
3286:
3282:
3268:
3264:
3263:
3258:
3255:
3251:
3250:
3245:
3242:
3238:
3237:
3232:
3229:
3225:
3224:
3219:
3216:
3212:
3211:
3206:
3203:
3199:
3198:
3193:
3190:
3186:
3185:
3180:
3179:
3177:
3173:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3143:
3141:
3137:
3131:
3128:
3126:
3125:Enzyme family
3123:
3121:
3118:
3116:
3113:
3112:
3110:
3106:
3100:
3097:
3095:
3092:
3090:
3089:Cooperativity
3087:
3085:
3082:
3081:
3079:
3075:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3048:Oxyanion hole
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3030:
3028:
3024:
3020:
3013:
3008:
3006:
3001:
2999:
2994:
2993:
2990:
2978:
2975:
2973:
2970:
2969:
2967:
2964:
2960:
2954:
2951:
2949:
2946:
2945:
2943:
2940:
2936:
2932:
2926:
2923:
2921:
2918:
2917:
2915:
2912:
2908:
2904:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2879:
2877:
2874:
2870:
2866:
2860:
2857:
2855:
2852:
2850:
2847:
2846:
2844:
2841:
2837:
2833:
2827:
2824:
2820:
2817:
2815:
2812:
2811:
2810:
2807:
2803:
2800:
2798:
2795:
2794:
2793:
2790:
2788:
2784:
2783:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2639:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2619:
2617:
2614:
2610:
2606:
2602:
2597:
2593:
2589:
2582:
2577:
2575:
2570:
2568:
2563:
2562:
2559:
2543:
2540:
2538:
2535:
2533:
2530:
2529:
2524:
2521:
2519:
2516:
2515:
2514:
2513:
2509:
2505:
2502:
2501:
2500:
2499:
2494:
2491:
2490:
2488:
2484:
2474:
2468:
2466:
2463:
2462:
2460:
2458:
2453:
2445:
2442:
2440:
2437:
2436:
2435:
2432:
2430:
2424:
2422:
2416:
2414:
2411:
2409:
2406:
2405:
2403:
2401:
2396:
2393:
2391:
2386:
2380:
2377:
2375:
2372:
2368:
2365:
2363:
2360:
2359:
2358:
2352:
2349:
2348:
2343:
2340:
2338:
2335:
2334:
2333:
2327:
2325:
2322:
2320:
2316:
2312:
2311:
2308:
2305:
2303:
2299:
2298:
2296:
2294:
2289:
2283:
2280:
2279:
2277:
2275:
2270:
2267:
2265:
2261:
2255:
2252:
2250:
2247:
2246:
2244:
2242:
2237:
2227:
2224:
2223:
2221:
2218:
2214:
2208:
2205:
2203:
2200:
2198:
2195:
2194:
2192:
2189:
2185:
2179:
2176:
2174:
2171:
2169:
2166:
2165:
2163:
2161:
2156:
2153:
2151:
2146:
2136:
2133:
2131:
2128:
2127:
2125:
2121:
2115:
2112:
2110:
2107:
2105:
2102:
2100:
2097:
2096:
2094:
2092:
2087:
2081:
2078:
2077:
2075:
2073:
2068:
2062:
2059:
2057:
2054:
2052:
2051:HMG-CoA lyase
2049:
2048:
2046:
2044:
2040:
2033:
2030:
2028:
2025:
2024:
2022:
2020:
2015:
2012:
2010:
2006:
2002:
1998:
1994:
1990:
1986:
1982:
1975:
1970:
1968:
1963:
1961:
1956:
1955:
1952:
1943:
1939:
1934:
1929:
1925:
1921:
1917:
1913:
1909:
1904:
1900:
1896:
1891:
1886:
1882:
1878:
1874:
1869:
1865:
1861:
1856:
1851:
1847:
1843:
1839:
1834:
1830:
1826:
1821:
1816:
1812:
1808:
1804:
1800:
1796:
1791:
1787:
1783:
1779:
1775:
1771:
1767:
1763:
1759:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1659:
1655:
1651:
1647:
1643:
1640:(7): 2263–6.
1639:
1635:
1630:
1626:
1622:
1618:
1614:
1610:
1606:
1601:
1597:
1593:
1589:
1585:
1581:
1577:
1573:
1569:
1564:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1527:
1523:
1519:
1514:
1509:
1505:
1501:
1497:
1492:
1488:
1484:
1479:
1474:
1471:(5): 831–66.
1470:
1466:
1462:
1457:
1453:
1449:
1444:
1439:
1435:
1431:
1427:
1422:
1418:
1414:
1409:
1404:
1399:
1394:
1390:
1386:
1382:
1378:
1374:
1369:
1365:
1361:
1356:
1351:
1348:(1): 135–56.
1347:
1343:
1339:
1334:
1333:
1328:
1319:
1315:
1310:
1305:
1301:
1297:
1293:
1289:
1285:
1278:
1275:
1270:
1264:
1261:
1256:
1252:
1247:
1242:
1238:
1234:
1230:
1226:
1222:
1215:
1212:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1172:
1169:
1164:
1160:
1154:
1151:
1146:
1142:
1136:
1133:
1129:
1125:
1120:
1118:
1116:
1112:
1108:
1104:
1099:
1097:
1095:
1091:
1084:
1082:
1080:
1076:
1072:
1068:
1060:
1058:
1056:
1055:granule cells
1050:
1048:
1044:
1040:
1035:
1033:
1029:
1025:
1021:
1013:
1011:
1009:
1006:
1005:
1000:
996:
992:
980:
975:
971:
967:
964:
960:
953:
951:
948:
944:
940:
936:
933:
929:
925:
918:
916:
910:
906:
903:
897:
895:
889:
885:
882:
878:
871:
869:
863:
859:
856:
850:
848:
842:
838:
835:
833:RefSeq (mRNA)
831:
824:
823:
818:
814:
811:
805:
804:
799:
795:
792:
790:
786:
779:
778:
773:
769:
766:
760:
759:
754:
750:
747:
745:
741:
734:
733:
728:
724:
721:
715:
714:
709:
705:
702:
700:
696:
693:
690:
688:
685:
681:
678:
674:
670:
663:
659:
654:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
604:
602:
599:
598:
592:
589:
587:
584:
582:
579:
577:
574:
573:
571:
568:
567:
559:
557:
554:
552:
549:
547:
544:
543:
541:
538:
537:
534:
533:Gene ontology
530:
526:
514:
509:
505:
500:
497:
495:
491:
483:
478:
467:
464:Gonadal ridge
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
390:parotid gland
389:
385:
381:
377:
374:renal medulla
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
3262:Translocases
3259:
3246:
3233:
3220:
3207:
3197:Transferases
3194:
3181:
3038:Binding site
2818:
2785:
2510:
2496:
2434:5α-Reductase
2390:sex hormones
2350:
2313:
2300:
2274:pregnenolone
1918:(2): 370–9.
1915:
1911:
1880:
1876:
1845:
1841:
1802:
1798:
1761:
1757:
1735:(1): 195–9.
1732:
1728:
1698:(4): 394–9.
1695:
1691:
1669:(2): 124–5.
1666:
1662:
1637:
1633:
1608:
1604:
1571:
1567:
1534:
1530:
1506:(1): 29–31.
1503:
1500:J. Hypertens
1499:
1468:
1464:
1433:
1429:
1380:
1376:
1345:
1341:
1291:
1287:
1277:
1263:
1228:
1224:
1214:
1184:(2): R11–7.
1181:
1177:
1171:
1162:
1153:
1144:
1135:
1064:
1051:
1036:
1032:HSD2 neurons
1017:
1002:
994:
990:
989:
912:
891:
865:
844:
820:
801:
775:
756:
730:
711:
691:
686:
452:otic vesicle
448:human kidney
436:right kidney
382:human kidney
344:
337:
303:106,250,620
290:106,245,387
64:External IDs
3033:Active site
2913:as acceptor
2413:17,20-Lyase
2302:aldosterone
2217:Desmosterol
2150:cholesterol
2061:Thiophorase
2043:Ketogenesis
1993:cholesterol
1465:Endocr. Rev
1342:Endocr. Rev
1020:aldosterone
546:NAD binding
394:skin of leg
202:67,437,553
189:67,430,652
42:Identifiers
3305:Categories
3236:Isomerases
3210:Hydrolases
3077:Regulation
2840:cytochrome
2241:Bile acids
2160:lanosterol
1995:synthesis
1981:Metabolism
1799:Biochem. J
1692:Nat. Genet
1225:Biochem. J
1130:, May 2017
1109:, May 2017
1085:References
432:left colon
348:(ortholog)
85:HomoloGene
3115:EC number
2911:disulfide
2498:sulfatase
2465:Aromatase
2457:estrogens
2400:androgens
2319:cortisone
1043:cortisone
1024:brainstem
915:NP_032315
894:NP_000187
868:NM_008289
847:NM_000196
677:Orthologs
576:cytoplasm
93:GeneCards
3316:EC 1.1.1
3139:Kinetics
3063:Cofactor
3026:Activity
2875:acceptor
2842:acceptor
2819:11β-HSD2
2814:11β-HSD1
2615:acceptor
2315:cortisol
2123:Geranyl-
1786:12550923
1729:Genomics
1720:30848352
1596:42872913
1522:15643119
1487:15466942
1452:12788832
1318:19261742
1126:–
1105:–
1039:cortisol
1014:Function
963:Wikidata
656:Sources:
444:yolk sac
3295:Biology
3249:Ligases
3019:Enzymes
2939:quinone
2523:SULT2A1
2518:SULT1A1
2019:HMG-CoA
1997:enzymes
1989:ketones
1942:9683587
1933:1377297
1899:9661590
1864:9398712
1829:8611186
1820:1217009
1778:8547170
1749:8530071
1712:7670488
1683:7656579
1654:7608290
1625:7593417
1588:2889032
1559:2845584
1539:Bibcode
1531:Science
1417:9707624
1385:Bibcode
1364:9034789
1309:2739715
1255:8611140
1246:1216963
1206:8240801
1198:7859916
1128:Ensembl
1107:Ensembl
1004:HSD11B2
789:UniProt
744:Ensembl
683:Species
662:QuickGO
460:saccule
323:pattern
181:16q22.1
97:HSD11B2
56:HSD11B2
49:Aliases
33:HSD11B2
3281:Portal
3223:Lyases
2977:L2HGDH
2963:1.1.99
2873:oxygen
2797:3β-HSD
1940:
1930:
1897:
1862:
1827:
1817:
1784:
1776:
1747:
1718:
1710:
1681:
1652:
1623:
1594:
1586:
1568:Lancet
1557:
1520:
1485:
1450:
1415:
1405:
1362:
1316:
1306:
1253:
1243:
1204:
1196:
999:enzyme
997:is an
949:search
947:PubMed
822:P51661
803:P80365
699:Entrez
494:BioGPS
456:cervix
440:uterus
378:rectum
81:104720
73:614232
3175:Types
2935:1.1.5
2907:1.1.4
2869:1.1.3
2836:1.1.2
2802:NSDHL
2605:1.1.1
2351:both:
2091:DMAPP
1782:S2CID
1716:S2CID
1592:S2CID
1408:21485
1202:S2CID
732:15484
692:Mouse
687:Human
658:Amigo
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:20088
3267:list
3260:EC7
3254:list
3247:EC6
3241:list
3234:EC5
3228:list
3221:EC4
3215:list
3208:EC3
3202:list
3195:EC2
3189:list
3182:EC1
2652:1B10
2613:NADP
2598:1.1)
2470:17β-
2426:17β-
2329:11β-
2219:path
2190:path
1938:PMID
1895:PMID
1860:PMID
1825:PMID
1774:PMID
1745:PMID
1708:PMID
1679:PMID
1650:PMID
1621:PMID
1584:PMID
1555:PMID
1518:PMID
1483:PMID
1448:PMID
1413:PMID
1360:PMID
1314:PMID
1251:PMID
1194:PMID
1008:gene
713:3291
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
69:OMIM
2826:17β
2809:11β
2672:7A2
2667:1C4
2662:1C3
2657:1C1
2647:1B1
2642:1A1
2609:NAD
2472:HSD
2455:To
2428:HSD
2420:HSD
2418:3β-
2398:To
2388:To
2356:HSD
2354:3β-
2331:HSD
2291:To
2272:To
2239:To
2158:To
2148:To
2089:To
2070:To
2017:To
1928:PMC
1920:doi
1885:doi
1850:doi
1815:PMC
1807:doi
1803:313
1766:doi
1737:doi
1700:doi
1671:doi
1642:doi
1613:doi
1576:doi
1547:doi
1535:242
1508:doi
1473:doi
1438:doi
1403:PMC
1393:doi
1350:doi
1304:PMC
1296:doi
1292:297
1241:PMC
1233:doi
1229:313
1186:doi
1182:105
299:End
198:End
101:OMA
77:MGI
3307::
2937::
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2792:3β
2607::
2596:EC
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