331:
308:
205:
230:
3148:
3178:
582:
3193:
3208:
337:
236:
42:
3163:
1414:
that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Multiple alternatively spliced transcript variants have been described for this gene, but only three
68:
1483:. The mice were also smaller, had less developed organs and had higher postnatal mortality (30%). The median lifespan of the mice that survived was less than 50% that of wild-type mice. Deficiencies in HNRNPK appear to specifically reduce the levels of the p42
1831:
Dejgaard K, Leffers H, Rasmussen HH, Madsen P, Kruse TA, Gesser B, et al. (February 1994). "Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing".
2726:
Tommerup N, Leffers H (March 1996). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A".
2611:
Buckanovich RJ, Posner JB, Darnell RB (October 1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system".
1341:. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.
3147:
2327:
Wada K, Inoue K, Hagiwara M (August 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy".
3177:
2570:"Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K"
344:
243:
3192:
3207:
2235:
Yang JP, Reddy TR, Truong KT, Suhasini M, Wong-Staal F (October 2002). "Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K".
925:
166:
906:
1384:
1311:
3127:
1813:
1795:
3236:
2904:"High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor"
1403:
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
330:
3013:
Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm".
2200:
Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm".
2773:
2058:"hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies"
1981:"hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies"
1232:
1225:
307:
1869:"Identity of the RNA-binding protein K of hnRNP particles with protein H16, a sequence-specific single strand DNA-binding protein"
2945:"The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2"
1965:
1782:
1761:
3162:
2799:"Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation"
1778:
229:
204:
65:
3241:
2406:"Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein"
1757:
146:
2980:"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing"
1530:
343:
242:
1406:
The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the
336:
235:
3044:"Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein"
3120:
1480:
1392:
1344:
RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are called
2535:"Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction"
1338:
970:
154:
1518:
951:
2869:"Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein"
2107:"c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs"
1916:
Klimek-Tomczak K, Mikula M, Dzwonek A, Paziewska A, Karczmarski J, Hennig E, et al. (February 2006).
1460:
2105:
Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW (July 2002).
1537:
1514:
1423:
1422:
are embryonic lethal in mice. Mice with both copies of the gene knocked out die before the 14th day of
2449:"Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains"
3113:
1492:
1388:
218:
133:
2156:"An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K"
1208:
1204:
1200:
1196:
1192:
1178:
1174:
1170:
1166:
1162:
1129:
1125:
1121:
1091:
1087:
1083:
1079:
1075:
1060:
1050:
1046:
776:
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
2867:
Schullery DS, Ostrowski J, Denisenko ON, Stempka L, Shnyreva M, Suzuki H, et al. (May 1999).
2931:
2785:
2757:
2636:
2392:
2260:
1396:
1318:
178:
1188:
1147:
1137:
1133:
1101:
1042:
1038:
1034:
2056:
Gallardo M, Lee HJ, Zhang X, Bueso-Ramos C, Pageon LR, McArthur M, et al. (October 2015).
1979:
Gallardo M, Lee HJ, Zhang X, Bueso-Ramos C, Pageon LR, McArthur M, et al. (October 2015).
3085:
3065:
3030:
3001:
2966:
2923:
2890:
2855:
2820:
2777:
2744:
2714:
2679:
2628:
2599:
2556:
2521:
2478:
2447:
Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, et al. (July 1994).
2435:
2384:
2344:
2309:
2280:"Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1"
2252:
2217:
2177:
2136:
2087:
2010:
1947:
1898:
1849:
1356:
1334:
581:
126:
58:
2367:
Bomsztyk K, Denisenko O, Ostrowski J (June 2004). "hnRNP K: one protein multiple processes".
1661:
3055:
3022:
2991:
2956:
2915:
2880:
2845:
2810:
2769:
2736:
2704:
2669:
2661:
2620:
2589:
2581:
2546:
2511:
2503:
2468:
2460:
2425:
2417:
2376:
2336:
2299:
2291:
2244:
2209:
2167:
2126:
2118:
2077:
2069:
2000:
1992:
1937:
1929:
1888:
1880:
1841:
1472:
1444:
423:
354:
298:
253:
174:
2492:"Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins"
1721:
1685:
1677:
1625:
1613:
1601:
17:
1364:
398:
2834:"Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K"
1513:
overexpression also appears to contribute to cancers via a different mechanism involving
1503:(cyclin-dependent kinase inhibitor 1), which is involved in pausing cell development for
1463:
in approximately 2% of cases. Additionally, a majority of mice who have had one of their
2943:
Wadd S, Bryant H, Filhol O, Scott JE, Hsieh TY, Everett RD, Clements JB (October 1999).
3156:: COMPLEX OF THE KH3 DOMAIN OF HNRNP K WITH A SINGLE_STRANDED 10MER DNA OLIGONUCLEOTIDE
2082:
2057:
2005:
1980:
1942:
1917:
1468:
1372:
41:
2674:
2649:
2594:
2569:
2551:
2534:
2516:
2491:
2473:
2448:
2430:
2405:
2340:
2304:
2279:
2131:
2106:
2029:
1893:
1868:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
3230:
3094:
2624:
2122:
1918:"Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa"
1307:
610:
3186:: Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA
2978:
Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC (March 2000).
2789:
2691:
Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ (October 1996).
2640:
2396:
2264:
2935:
2832:
Hsieh TY, Matsumoto M, Chou HC, Schneider R, Hwang SB, Lee AS, Lai MM (July 1998).
2758:"Molecular cloning of Fyn-associated molecules in the mouse central nervous system"
1303:
416:
195:
158:
182:
2073:
1996:
1818:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1800:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1496:
1407:
1399:
in the nucleus and appear to influence pre-mRNA processing and other aspects of
1360:
499:
1729:
1504:
1411:
315:
212:
162:
3060:
3043:
2961:
2944:
2885:
2868:
2850:
2833:
2815:
2798:
2709:
2692:
1884:
2295:
870:
559:
437:
382:
369:
281:
268:
170:
3069:
3034:
3026:
3005:
2970:
2927:
2919:
2894:
2740:
2585:
2388:
2348:
2313:
2256:
2248:
2221:
2213:
2181:
2172:
2155:
2140:
2091:
2014:
1951:
1933:
1845:
3201:: Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA
2996:
2979:
2859:
2824:
2781:
2774:
10.1002/(SICI)1097-4547(19970601)48:5<407::AID-JNR3>3.0.CO;2-I
2748:
2718:
2683:
2665:
2632:
2603:
2560:
2525:
2507:
2482:
2464:
2439:
1902:
1853:
1272:
1267:
3216:: Crystal Structure of the third KH domain of hnRNP K at 0.95A resolution
2421:
2278:
Côté J, Boisvert FM, Boulanger MC, Bedford MT, Richard S (January 2003).
1476:
1256:
1015:
996:
624:
DNA-binding transcription activator activity, RNA polymerase II-specific
3099:
3089:
2380:
1665:
1657:
1653:
1649:
1645:
1593:
1555:
1484:
1368:
1292:
982:
937:
2490:
Bustelo XR, Suen KL, Michael WM, Dreyfuss G, Barbacid M (March 1995).
103:
99:
95:
91:
87:
3042:
Shnyreva M, Schullery DS, Suzuki H, Higaki Y, Bomsztyk K (May 2000).
2650:"Heterogeneous nuclear ribonucleoprotein K is a transcription factor"
1589:
1549:
1315:
1240:
892:
629:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
2903:
137:, CSBP, HNRPK, TUNP, AUKS, heterogeneous nuclear ribonucleoprotein K
1733:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1681:
1669:
1641:
1637:
1621:
1609:
1605:
1597:
1585:
1573:
1567:
1561:
1488:
3098:(Human Heterogeneous nuclear ribonucleoprotein K (HNRPK)) at the
855:
851:
2648:
Michelotti EF, Michelotti GA, Aronsohn AI, Levens D (May 1996).
2568:
Aasheim HC, Loukianova T, Deggerdal A, Smeland EB (March 1994).
1717:
1673:
1633:
1629:
1617:
1543:
1400:
1299:
150:
3109:
590:
3105:
1966:"Entrez Gene: HNRPK heterogeneous nuclear ribonucleoprotein K"
1725:
1500:
1330:
1326:
2533:
Hobert O, Jallal B, Schlessinger J, Ullrich A (August 1994).
2329:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
1383:
This gene belongs to the subfamily of ubiquitously expressed
3084:
Overview of all the structural information available in the
2154:
Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002).
2797:
Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC (April 1998).
2693:"Identification of Itk/Tsk Src homology 3 domain ligands"
821:
positive regulation of transcription by RNA polymerase II
806:
regulation of low-density lipoprotein particle clearance
406:
2902:
Baber JL, Libutti D, Levens D, Tjandra N (June 1999).
771:
negative regulation of mRNA splicing, via spliceosome
571:
761:
positive regulation of receptor-mediated endocytosis
2404:Matunis MJ, Michael WM, Dreyfuss G (January 1992).
1355:Protein K has been the subject of study related to
1161:
1120:
1074:
1033:
1867:Gaillard C, Cabannes E, Strauss F (October 1994).
1774:
1772:
1770:
1753:
1751:
1749:
353:
252:
766:regulation of transcription by RNA polymerase II
2195:
2193:
2191:
1779:GRCm38: Ensembl release 89: ENSMUSG00000021546
3121:
1375:was found to be specific to cancerous cells.
8:
1395:(hnRNA). These proteins are associated with
1758:GRCh38: Ensembl release 89: ENSG00000165119
1495:involved in the differentiation of certain
3128:
3114:
3106:
1158:
1117:
1071:
1030:
866:
781:regulation of transcription, DNA-templated
606:
394:
293:
190:
76:
3059:
2995:
2960:
2884:
2849:
2814:
2708:
2673:
2593:
2550:
2515:
2472:
2429:
2303:
2171:
2130:
2081:
2004:
1941:
1892:
1312:heterogeneous ribonucleoprotein particles
1285:Heterogeneous nuclear ribonucleoprotein K
1385:heterogeneous nuclear ribonucleoproteins
1325:. Both proteins bind to single-stranded
826:negative regulation of apoptotic process
3171:: C-TERMINAL KH DOMAIN OF HNRNP K (KH3)
3143:
1745:
2756:Kai N, Mishina M, Yagi T (June 1997).
31:
2051:
2049:
1581:Human proteins containing a KH domain
1455:Deletions in the region encompassing
358:
319:
314:
257:
216:
211:
7:
1415:variants have been fully described.
3048:The Journal of Biological Chemistry
2949:The Journal of Biological Chemistry
2873:The Journal of Biological Chemistry
2838:The Journal of Biological Chemistry
2803:The Journal of Biological Chemistry
2697:The Journal of Biological Chemistry
2539:The Journal of Biological Chemistry
2160:The Journal of Biological Chemistry
1447:, also known as Au–Kline syndrome.
1337:, the protein responsible for most
1333:and can stimulate the activity of
1006:
987:
961:
942:
916:
897:
836:transcription by RNA polymerase II
576:
494:
432:
411:
25:
1295:that in humans is encoded by the
3206:
3191:
3176:
3161:
3146:
2762:Journal of Neuroscience Research
2123:10.1128/mcb.22.13.4535-4543.2002
1459:have been found in the cells of
580:
342:
335:
329:
306:
241:
234:
228:
203:
40:
664:protein domain specific binding
2654:Molecular and Cellular Biology
2496:Molecular and Cellular Biology
2453:Molecular and Cellular Biology
2410:Molecular and Cellular Biology
2111:Molecular and Cellular Biology
811:mRNA splicing, via spliceosome
591:More reference expression data
560:More reference expression data
1:
2552:10.1016/S0021-9258(17)31979-8
2341:10.1016/s0167-4889(02)00202-1
2284:Molecular Biology of the Cell
327:
226:
29:Human protein and coding gene
3015:Journal of Molecular Biology
2908:Journal of Molecular Biology
2625:10.1016/0896-6273(93)90077-5
2202:Journal of Molecular Biology
1834:Journal of Molecular Biology
1418:Mutations in both copies of
786:transcription, DNA-templated
705:catalytic step 2 spliceosome
3237:Genes on human chromosome 9
2074:10.1016/j.ccell.2015.09.001
1997:10.1016/j.ccell.2015.09.001
649:single-stranded DNA binding
480:right lobe of thyroid gland
18:Protein K (gene expression)
3258:
1475:, with a third developing
745:cytoplasmic stress granule
484:left lobe of thyroid gland
3141:
1922:British Journal of Cancer
1814:"Mouse PubMed Reference:"
1796:"Human PubMed Reference:"
1481:hepatocellular carcinomas
1410:and has three repeats of
1393:heterogeneous nuclear RNA
1387:(hnRNPs). The hnRNPs are
1310:(mRNA) as a component of
1271:
1266:
1262:
1255:
1239:
1220:
1185:
1144:
1113:
1098:
1057:
1026:
1013:
1009:
994:
990:
981:
968:
964:
949:
945:
936:
923:
919:
904:
900:
891:
876:
869:
865:
849:
669:identical protein binding
609:
605:
588:
579:
570:
557:
506:
497:
444:
435:
405:
397:
393:
376:
363:
326:
305:
296:
292:
275:
262:
225:
202:
193:
189:
144:
141:
131:
124:
119:
84:
79:
62:
57:
52:
48:
39:
34:
3061:10.1074/jbc.275.20.15498
2984:Human Molecular Genetics
2962:10.1074/jbc.274.41.28991
2886:10.1074/jbc.274.21.15101
2851:10.1074/jbc.273.28.17651
2816:10.1074/jbc.273.17.10784
2710:10.1074/jbc.271.41.25646
1529:HNRPK has been shown to
1391:, and they complex with
2296:10.1091/mbc.E02-08-0484
2034:Genetics Home Reference
1233:Chr 13: 58.39 – 58.4 Mb
1226:Chr 9: 83.97 – 83.98 Mb
3027:10.1006/jmbi.2000.3687
2920:10.1006/jmbi.1999.2818
2741:10.1006/geno.1996.0121
2574:Nucleic Acids Research
2249:10.1038/sj.onc.1205759
2214:10.1006/jmbi.2000.3687
2173:10.1074/jbc.M206981200
1934:10.1038/sj.bjc.6602938
1885:10.1093/nar/22.20.4183
1873:Nucleic Acids Research
1846:10.1006/jmbi.1994.1116
1461:acute myeloid leukemia
546:neural layer of retina
2666:10.1128/MCB.16.5.2350
2508:10.1128/MCB.15.3.1324
2465:10.1128/MCB.14.7.4509
1430:Clinical significance
1424:embryonic development
1302:. It is found in the
841:RNA metabolic process
715:extracellular exosome
321:Chromosome 13 (mouse)
3242:RNA-binding proteins
2586:10.1093/nar/22.6.959
2422:10.1128/MCB.12.1.164
1493:transcription factor
1389:RNA-binding proteins
735:extracellular matrix
725:spliceosomal complex
639:nucleic acid binding
472:smooth muscle tissue
219:Chromosome 9 (human)
80:List of PDB id codes
53:Available structures
2997:10.1093/hmg/9.5.685
2030:"Au-Kline syndrome"
1467:genes artificially
1363:event inducing the
816:signal transduction
538:ganglionic eminence
456:ganglionic eminence
2381:10.1002/bies.20048
1479:and 4% developing
1339:gene transcription
1306:that binds to pre-
971:ENSMUSG00000021546
754:Biological process
678:Cellular component
617:Molecular function
468:right uterine tube
183:HNRNPK - orthologs
3224:
3223:
3054:(20): 15498–503.
1357:colorectal cancer
1335:RNA polymerase II
1282:
1281:
1278:
1277:
1251:
1250:
1216:
1215:
1155:
1154:
1109:
1108:
1068:
1067:
1022:
1021:
1003:
1002:
977:
976:
958:
957:
932:
931:
913:
912:
861:
860:
601:
600:
597:
596:
566:
565:
553:
552:
491:
490:
389:
388:
288:
287:
115:
114:
111:
110:
63:Ortholog search:
16:(Redirected from
3249:
3210:
3195:
3180:
3165:
3150:
3130:
3123:
3116:
3107:
3073:
3063:
3038:
3009:
2999:
2974:
2964:
2939:
2898:
2888:
2863:
2853:
2828:
2818:
2809:(17): 10784–91.
2793:
2752:
2722:
2712:
2703:(41): 25646–56.
2687:
2677:
2644:
2607:
2597:
2564:
2554:
2529:
2519:
2486:
2476:
2443:
2433:
2400:
2353:
2352:
2324:
2318:
2317:
2307:
2275:
2269:
2268:
2232:
2226:
2225:
2197:
2186:
2185:
2175:
2151:
2145:
2144:
2134:
2102:
2096:
2095:
2085:
2053:
2044:
2043:
2041:
2040:
2025:
2019:
2018:
2008:
1976:
1970:
1969:
1962:
1956:
1955:
1945:
1913:
1907:
1906:
1896:
1864:
1858:
1857:
1828:
1822:
1821:
1810:
1804:
1803:
1792:
1786:
1776:
1765:
1755:
1477:lymphoid cancers
1445:Okamoto syndrome
1435:Okamoto syndrome
1264:
1263:
1235:
1228:
1211:
1159:
1150:
1118:
1114:RefSeq (protein)
1104:
1072:
1063:
1031:
1007:
988:
962:
943:
917:
898:
867:
659:cadherin binding
607:
593:
584:
577:
562:
518:ventricular zone
514:genital tubercle
502:
500:Top expressed in
495:
452:ventricular zone
440:
438:Top expressed in
433:
412:
395:
385:
372:
361:
346:
339:
333:
322:
310:
294:
284:
271:
260:
245:
238:
232:
221:
207:
191:
185:
136:
129:
106:
77:
71:
50:
49:
44:
32:
21:
3257:
3256:
3252:
3251:
3250:
3248:
3247:
3246:
3227:
3226:
3225:
3220:
3217:
3211:
3202:
3196:
3187:
3181:
3172:
3166:
3157:
3151:
3137:
3134:
3081:
3076:
3041:
3012:
2977:
2955:(41): 28991–8.
2942:
2901:
2879:(21): 15101–9.
2866:
2844:(28): 17651–9.
2831:
2796:
2755:
2725:
2690:
2647:
2610:
2567:
2545:(32): 20225–8.
2532:
2489:
2446:
2403:
2366:
2362:
2360:Further reading
2357:
2356:
2326:
2325:
2321:
2277:
2276:
2272:
2243:(47): 7187–94.
2234:
2233:
2229:
2199:
2198:
2189:
2166:(43): 40403–9.
2153:
2152:
2148:
2117:(13): 4535–43.
2104:
2103:
2099:
2055:
2054:
2047:
2038:
2036:
2027:
2026:
2022:
1978:
1977:
1973:
1964:
1963:
1959:
1915:
1914:
1910:
1866:
1865:
1861:
1830:
1829:
1825:
1812:
1811:
1807:
1794:
1793:
1789:
1777:
1768:
1756:
1747:
1742:
1583:
1527:
1473:myeloid cancers
1453:
1437:
1432:
1381:
1273:View/Edit Mouse
1268:View/Edit Human
1231:
1224:
1221:Location (UCSC)
1207:
1203:
1199:
1195:
1191:
1187:
1181:
1177:
1173:
1169:
1165:
1146:
1140:
1136:
1132:
1128:
1124:
1100:
1094:
1090:
1086:
1082:
1078:
1059:
1053:
1049:
1045:
1041:
1037:
952:ENSG00000165119
845:
801:mRNA processing
749:
710:cell projection
673:
634:protein binding
589:
558:
549:
544:
540:
536:
532:
528:
524:
520:
516:
512:
498:
487:
482:
478:
474:
470:
466:
462:
458:
454:
450:
448:Achilles tendon
436:
380:
367:
359:
349:
348:
347:
340:
320:
297:Gene location (
279:
266:
258:
248:
247:
246:
239:
217:
194:Gene location (
145:
132:
125:
86:
64:
30:
23:
22:
15:
12:
11:
5:
3255:
3253:
3245:
3244:
3239:
3229:
3228:
3222:
3221:
3219:
3218:
3212:
3205:
3203:
3197:
3190:
3188:
3182:
3175:
3173:
3167:
3160:
3158:
3152:
3145:
3142:
3139:
3138:
3135:
3133:
3132:
3125:
3118:
3110:
3104:
3103:
3080:
3079:External links
3077:
3075:
3074:
3039:
3021:(3): 395–405.
3010:
2975:
2940:
2899:
2864:
2829:
2794:
2753:
2723:
2688:
2660:(5): 2350–60.
2645:
2608:
2565:
2530:
2502:(3): 1324–32.
2487:
2459:(7): 4509–21.
2444:
2401:
2363:
2361:
2358:
2355:
2354:
2319:
2270:
2227:
2208:(3): 395–405.
2187:
2146:
2097:
2068:(4): 486–499.
2045:
2028:Reference GH.
2020:
1991:(4): 486–499.
1971:
1957:
1908:
1879:(20): 4183–6.
1859:
1823:
1805:
1787:
1766:
1744:
1743:
1741:
1738:
1582:
1579:
1578:
1577:
1571:
1565:
1559:
1553:
1547:
1541:
1526:
1523:
1452:
1449:
1436:
1433:
1431:
1428:
1380:
1377:
1373:point mutation
1359:, in which an
1329:as well as to
1280:
1279:
1276:
1275:
1270:
1260:
1259:
1253:
1252:
1249:
1248:
1246:
1244:
1237:
1236:
1229:
1222:
1218:
1217:
1214:
1213:
1183:
1182:
1156:
1153:
1152:
1142:
1141:
1115:
1111:
1110:
1107:
1106:
1096:
1095:
1069:
1066:
1065:
1055:
1054:
1028:
1024:
1023:
1020:
1019:
1011:
1010:
1004:
1001:
1000:
992:
991:
985:
979:
978:
975:
974:
966:
965:
959:
956:
955:
947:
946:
940:
934:
933:
930:
929:
921:
920:
914:
911:
910:
902:
901:
895:
889:
888:
883:
878:
874:
873:
863:
862:
859:
858:
847:
846:
844:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
796:RNA processing
793:
788:
783:
778:
773:
768:
763:
757:
755:
751:
750:
748:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
695:focal adhesion
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
620:
618:
614:
613:
603:
602:
599:
598:
595:
594:
586:
585:
574:
568:
567:
564:
563:
555:
554:
551:
550:
548:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
510:tail of embryo
507:
504:
503:
492:
489:
488:
486:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
442:
441:
429:
428:
420:
409:
403:
402:
399:RNA expression
391:
390:
387:
386:
378:
374:
373:
365:
362:
357:
351:
350:
341:
334:
328:
324:
323:
318:
312:
311:
303:
302:
290:
289:
286:
285:
277:
273:
272:
264:
261:
256:
250:
249:
240:
233:
227:
223:
222:
215:
209:
208:
200:
199:
187:
186:
143:
139:
138:
130:
122:
121:
117:
116:
113:
112:
109:
108:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3254:
3243:
3240:
3238:
3235:
3234:
3232:
3215:
3209:
3204:
3200:
3194:
3189:
3185:
3179:
3174:
3170:
3164:
3159:
3155:
3149:
3144:
3140:
3131:
3126:
3124:
3119:
3117:
3112:
3111:
3108:
3101:
3097:
3096:
3091:
3087:
3083:
3082:
3078:
3071:
3067:
3062:
3057:
3053:
3049:
3045:
3040:
3036:
3032:
3028:
3024:
3020:
3016:
3011:
3007:
3003:
2998:
2993:
2990:(5): 685–94.
2989:
2985:
2981:
2976:
2972:
2968:
2963:
2958:
2954:
2950:
2946:
2941:
2937:
2933:
2929:
2925:
2921:
2917:
2914:(4): 949–62.
2913:
2909:
2905:
2900:
2896:
2892:
2887:
2882:
2878:
2874:
2870:
2865:
2861:
2857:
2852:
2847:
2843:
2839:
2835:
2830:
2826:
2822:
2817:
2812:
2808:
2804:
2800:
2795:
2791:
2787:
2783:
2779:
2775:
2771:
2768:(5): 407–24.
2767:
2763:
2759:
2754:
2750:
2746:
2742:
2738:
2734:
2730:
2724:
2720:
2716:
2711:
2706:
2702:
2698:
2694:
2689:
2685:
2681:
2676:
2671:
2667:
2663:
2659:
2655:
2651:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2619:(4): 657–72.
2618:
2614:
2609:
2605:
2601:
2596:
2591:
2587:
2583:
2580:(6): 959–64.
2579:
2575:
2571:
2566:
2562:
2558:
2553:
2548:
2544:
2540:
2536:
2531:
2527:
2523:
2518:
2513:
2509:
2505:
2501:
2497:
2493:
2488:
2484:
2480:
2475:
2470:
2466:
2462:
2458:
2454:
2450:
2445:
2441:
2437:
2432:
2427:
2423:
2419:
2416:(1): 164–71.
2415:
2411:
2407:
2402:
2398:
2394:
2390:
2386:
2382:
2378:
2375:(6): 629–38.
2374:
2370:
2365:
2364:
2359:
2350:
2346:
2342:
2338:
2335:(1–3): 1–10.
2334:
2330:
2323:
2320:
2315:
2311:
2306:
2301:
2297:
2293:
2290:(1): 274–87.
2289:
2285:
2281:
2274:
2271:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2238:
2231:
2228:
2223:
2219:
2215:
2211:
2207:
2203:
2196:
2194:
2192:
2188:
2183:
2179:
2174:
2169:
2165:
2161:
2157:
2150:
2147:
2142:
2138:
2133:
2128:
2124:
2120:
2116:
2112:
2108:
2101:
2098:
2093:
2089:
2084:
2079:
2075:
2071:
2067:
2063:
2059:
2052:
2050:
2046:
2035:
2031:
2024:
2021:
2016:
2012:
2007:
2002:
1998:
1994:
1990:
1986:
1982:
1975:
1972:
1967:
1961:
1958:
1953:
1949:
1944:
1939:
1935:
1931:
1928:(4): 586–92.
1927:
1923:
1919:
1912:
1909:
1904:
1900:
1895:
1890:
1886:
1882:
1878:
1874:
1870:
1863:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1827:
1824:
1819:
1815:
1809:
1806:
1801:
1797:
1791:
1788:
1784:
1780:
1775:
1773:
1771:
1767:
1763:
1759:
1754:
1752:
1750:
1746:
1739:
1737:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1580:
1575:
1572:
1569:
1566:
1563:
1560:
1557:
1554:
1551:
1548:
1545:
1542:
1539:
1536:
1535:
1534:
1532:
1524:
1522:
1520:
1519:transcription
1516:
1512:
1508:
1506:
1502:
1499:, as well as
1498:
1494:
1491:, which is a
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1451:Blood cancers
1450:
1448:
1446:
1442:
1439:Mutations in
1434:
1429:
1427:
1425:
1421:
1416:
1413:
1409:
1404:
1402:
1398:
1394:
1390:
1386:
1378:
1376:
1374:
1371:containing a
1370:
1366:
1362:
1358:
1353:
1351:
1347:
1342:
1340:
1336:
1332:
1328:
1324:
1320:
1317:
1313:
1309:
1308:messenger RNA
1305:
1301:
1298:
1294:
1290:
1286:
1274:
1269:
1265:
1261:
1258:
1254:
1247:
1245:
1242:
1238:
1234:
1230:
1227:
1223:
1219:
1212:
1210:
1206:
1202:
1198:
1194:
1190:
1184:
1180:
1176:
1172:
1168:
1164:
1160:
1157:
1151:
1149:
1143:
1139:
1135:
1131:
1127:
1123:
1119:
1116:
1112:
1105:
1103:
1097:
1093:
1089:
1085:
1081:
1077:
1073:
1070:
1064:
1062:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1029:
1027:RefSeq (mRNA)
1025:
1018:
1017:
1012:
1008:
1005:
999:
998:
993:
989:
986:
984:
980:
973:
972:
967:
963:
960:
954:
953:
948:
944:
941:
939:
935:
928:
927:
922:
918:
915:
909:
908:
903:
899:
896:
894:
890:
887:
884:
882:
879:
875:
872:
868:
864:
857:
853:
848:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
791:viral process
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
758:
756:
753:
752:
746:
743:
741:
738:
736:
733:
731:
730:cell junction
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
612:
611:Gene ontology
608:
604:
592:
587:
583:
578:
575:
573:
569:
561:
556:
545:
541:
537:
534:mesencephalon
533:
529:
525:
521:
517:
513:
509:
508:
505:
501:
496:
493:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
446:
443:
439:
434:
431:
430:
427:
425:
421:
419:
418:
414:
413:
410:
408:
404:
400:
396:
392:
384:
379:
375:
371:
366:
360:13|13 B1
356:
352:
345:
338:
332:
325:
317:
313:
309:
304:
300:
295:
291:
283:
278:
274:
270:
265:
255:
251:
244:
237:
231:
224:
220:
214:
210:
206:
201:
197:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
140:
135:
128:
123:
118:
107:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
3213:
3198:
3183:
3168:
3153:
3093:
3051:
3047:
3018:
3014:
2987:
2983:
2952:
2948:
2911:
2907:
2876:
2872:
2841:
2837:
2806:
2802:
2765:
2761:
2735:(2): 297–8.
2732:
2728:
2700:
2696:
2657:
2653:
2616:
2612:
2577:
2573:
2542:
2538:
2499:
2495:
2456:
2452:
2413:
2409:
2372:
2368:
2332:
2328:
2322:
2287:
2283:
2273:
2240:
2236:
2230:
2205:
2201:
2163:
2159:
2149:
2114:
2110:
2100:
2065:
2061:
2037:. Retrieved
2033:
2023:
1988:
1984:
1974:
1960:
1925:
1921:
1911:
1876:
1872:
1862:
1840:(1): 33–48.
1837:
1833:
1826:
1817:
1808:
1799:
1790:
1584:
1528:
1525:Interactions
1517:rather than
1510:
1509:
1464:
1456:
1454:
1440:
1438:
1419:
1417:
1405:
1382:
1354:
1349:
1345:
1343:
1322:
1321:is known as
1304:cell nucleus
1296:
1288:
1284:
1283:
1209:NP_001347424
1205:NP_001347423
1201:NP_001347422
1197:NP_001347420
1193:NP_001347419
1186:
1179:NP_001288274
1175:NP_001288273
1171:NP_001288272
1167:NP_001288270
1163:NP_001288269
1145:
1130:NP_001305117
1126:NP_001305116
1122:NP_001305115
1099:
1092:NM_001301345
1088:NM_001301344
1084:NM_001301343
1080:NM_001301341
1076:NM_001301340
1061:NM_001318188
1058:
1051:NM_001318187
1047:NM_001318186
1014:
995:
969:
950:
924:
905:
885:
880:
831:RNA splicing
542:spermatocyte
422:
415:
142:External IDs
85:
26:
3136:PDB gallery
2062:Cancer Cell
1985:Cancer Cell
1515:translation
1497:blood cells
1469:knocked out
1408:nucleoplasm
1361:RNA editing
1323:protein H16
740:nucleoplasm
654:RNA binding
644:DNA binding
522:neural tube
381:58,403,343
368:58,391,142
280:83,980,616
267:83,968,083
120:Identifiers
3231:Categories
2039:2019-11-30
1785:, May 2017
1764:, May 2017
1740:References
1505:DNA repair
1471:developed
1412:KH domains
1365:expression
1346:K-homology
476:left ovary
426:(ortholog)
163:HomoloGene
2369:BioEssays
1397:pre-mRNAs
1352:domains.
1289:protein K
1189:NP_079555
1148:NP_112553
1138:NP_112552
1134:NP_002131
1102:NM_025279
1043:NM_031263
1039:NM_031262
1035:NM_002140
871:Orthologs
685:cytoplasm
171:GeneCards
3070:10809782
3035:10772858
3006:10749975
2971:10506147
2928:10369774
2895:10329716
2790:33016242
2729:Genomics
2641:22554933
2397:22108788
2389:15170860
2349:12183049
2314:12529443
2265:26091319
2257:12370808
2237:Oncogene
2222:10772858
2182:12183465
2141:12052863
2092:26412324
2015:26412324
1952:16404425
1781:–
1760:–
1732:;
1728:;
1531:interact
1379:Function
1257:Wikidata
850:Sources:
720:podosome
690:membrane
526:epiblast
464:monocyte
460:appendix
3100:PDBe-KB
3090:UniProt
2936:6846849
2860:9651361
2825:9553145
2782:9185665
2749:8833161
2719:8810341
2684:8628302
2633:8398153
2604:8152927
2561:8051112
2526:7862126
2483:7516469
2440:1729596
2083:4652598
2006:4652598
1943:2361188
1903:7524036
1854:8107114
1783:Ensembl
1762:Ensembl
1720:;
1676:;
1666:KHDRBS3
1662:KHDRBS2
1658:KHDRBS1
1654:IGF2BP3
1650:IGF2BP2
1646:IGF2BP1
1636:;
1632:;
1620:;
1594:ANKRD17
1556:KHDRBS1
1485:isoform
1369:isoform
1319:homolog
1293:protein
1291:) is a
983:UniProt
938:Ensembl
877:Species
856:QuickGO
700:nucleus
401:pattern
259:9q21.32
127:Aliases
3095:P61978
3068:
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3004:
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2934:
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2858:
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1600:;
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1465:HNRNPK
1457:HNRNPK
1443:cause
1441:HNRNPK
1420:HNRNPK
1367:of an
1316:simian
1314:. The
1297:HNRNPK
1287:(also
1243:search
1241:PubMed
1016:P61979
997:P61978
893:Entrez
572:BioGPS
175:HNRNPK
151:600712
134:HNRNPK
35:HNRNPK
2932:S2CID
2786:S2CID
2637:S2CID
2393:S2CID
2261:S2CID
1734:TDRKH
1722:PNPT1
1714:PCBP4
1710:PCBP3
1706:PCBP2
1702:PCBP1
1698:NOVA2
1694:NOVA1
1690:MEX3D
1686:MEX3C
1682:MEX3B
1678:MEX3A
1670:KHSRP
1642:HNRPK
1638:HDLBP
1626:FUBP3
1622:FUBP1
1614:DPPA5
1610:DDX53
1606:DDX43
1602:BICC1
1598:ASCC1
1592:;
1586:AKAP1
1574:PTBP1
1570:, and
1568:PRMT1
1562:PCBP2
1489:CEBPA
926:15387
886:Mouse
881:Human
852:Amigo
530:ovary
424:Mouse
417:Human
364:Start
299:Mouse
263:Start
196:Human
167:81909
159:99894
3214:1zzk
3199:1zzj
3184:1zzi
3169:1khm
3154:1j5k
3088:for
3066:PMID
3031:PMID
3002:PMID
2967:PMID
2924:PMID
2891:PMID
2856:PMID
2821:PMID
2778:PMID
2745:PMID
2715:PMID
2680:PMID
2629:PMID
2600:PMID
2557:PMID
2522:PMID
2479:PMID
2436:PMID
2385:PMID
2345:PMID
2333:1591
2310:PMID
2253:PMID
2218:PMID
2178:PMID
2137:PMID
2088:PMID
2011:PMID
1948:PMID
1899:PMID
1850:PMID
1718:PNO1
1674:KRR1
1668:;
1664:;
1660:;
1656:;
1652:;
1634:FXR2
1630:FXR1
1618:FMR1
1596:;
1544:DDX1
1401:mRNA
1300:gene
907:3190
407:Bgee
355:Band
316:Chr.
254:Band
213:Chr.
147:OMIM
104:1ZZK
100:1ZZJ
96:1ZZI
92:1KHM
88:1J5K
69:RCSB
66:PDBe
3086:PDB
3056:doi
3052:275
3023:doi
3019:298
2992:doi
2957:doi
2953:274
2916:doi
2912:289
2881:doi
2877:274
2846:doi
2842:273
2811:doi
2807:273
2770:doi
2737:doi
2705:doi
2701:271
2670:PMC
2662:doi
2621:doi
2590:PMC
2582:doi
2547:doi
2543:269
2512:PMC
2504:doi
2469:PMC
2461:doi
2426:PMC
2418:doi
2377:doi
2337:doi
2300:PMC
2292:doi
2245:doi
2210:doi
2206:298
2168:doi
2164:277
2127:PMC
2119:doi
2078:PMC
2070:doi
2001:PMC
1993:doi
1938:PMC
1930:doi
1889:PMC
1881:doi
1842:doi
1838:236
1730:SF1
1726:QKI
1538:CSK
1501:p21
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1327:DNA
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276:End
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