2080:
1841:-cat domain along the upper surface of the catalytic region. The OGT-UDP-peptide complex has a larger space between the TPR domain and the catalytic region than the OGT-UDP complex. The CKII peptide, which contains three serine residues and a threonine residue, binds in this space. In 2021 a 5Å CryoEM analysis revealed the relationship between the catalytic domains and the intact TPR regions confirming the dimer arrangement first seen in the TPR alone X ray structure. This structure supports an ordered sequential bi-bi mechanism that matches the fact that “at saturating peptide concentrations, a
376:
353:
250:
275:
1873:
641:
627:
634:
382:
281:
4748:
31:
1861:-acetylglucosamine transferase has not been extensively studied either, since there is not a confirmed crystal structure of the enzyme. A proposed mechanism by Lazarus et al. is supported by product inhibition patterns of UDP at saturating peptide conditions. This mechanism proceeds with starting materials Uridine diphosphate
1749:
OGT cleaves Host Cell Factor C1, at one or more of 6 repeating 26 amino acid sequences. The TPR domain of OGT binds to the carboxyl terminal portion of an HCF1 proteolytic repeat so that the cleavage region is in the glycosyltransferase active site above uridine-diphosphate-GlcNAc The large
1991:-acetylglucosamine transferase. Aside from proton transfers the reaction proceeds in one step, as shown in Figure 2. Figure 2 uses a lone serine residue as a representative of the peptide with a reactive hydroxyl group. Threonine could have also been used in the mechanism.
57:
1750:
proportion of OGT complexed with HCF1 is necessary for HCF1 cleavage, and HCFC1 is required for OGT stabilization in the nucleus. HCF1 regulates OGT stability using a post-transcriptional mechanism, however the mechanism of the interaction with HCFC1 is still unknown.
2103:-GlcNAc transferase is part of a dynamic competition for a serine or threonine hydroxyl functional group in a peptide unit. Figure 3 shows an example of both reciprocal same-site occupancy and adjacent-site occupancy. For the same-site occupancy, OGT competes with
2184:-GlcNAcylation may have therapeutic effects for Alzheimer's disease patients. Brain glucose metabolism is impaired in Alzheimer's disease, and a study suggests that this leads to hyperphosphorylation of tau and degerenation of tau
2059:. Further optimization led to the development of OSMI-2, OSMI-3, and OSMI-4, which bind OGT with low-nanomolar affinity. X-ray crystallography showed that the quinolinone-6-sulfonamide scaffold of OSMI compounds act as a
2039:-GlcNAc is not efficiently utilized as a donor sugar by OGT, possibly due to distortion of the pyranose ring by replacement of oxygen with sulfur. As other glycosyltransferases utilize UDP-GlcNAc as a donor sugar, UDP-5
2153:-GlcNAc, which can alter the function of proteins in the body through downstream effects. OGT inhibits the activity of 6-phosophofructosekinase PFKL by mediating the glycosylation process. This then acts as a part of
2083:
Figure 3: Dynamic
Competition between glycosylation and phosphorylation of proteins. A: Competition between OGT and kinase for the serine or threonine functional group of a protein. B: Adjacent-site occupancy where
1658:
specificity of nearby sites by steric or electrostatic effects. Two transcript variants encoding cytoplasmic and mitochondrial isoforms have been found for this gene. OGT glycosylates many proteins including:
3893:
3888:
1880:-GlcNAc transferase. It is an ordered sequential bi-bi mechanism with only one step, not including a proton transfer. The peptide is represented by a serine residue with a reactive hydroxyl group.
4266:
4142:
2548:"Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase"
3933:
1798:. The binding sites have been determined for the 110 kDa subunit. It has 3 binding sites at amino acid residues 849, 852, and 935. The probable active site is at residue 508.
3033:
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al. (February 2008). "Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance".
1578:
389:
288:
2107:
to catalyze the glycosylation of the protein instead of phosphorylation. The adjacent-site occupancy example shows the naked protein catalyzed by OGT converted to a
4247:
4315:
3764:
2942:"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1"
1597:
4424:
4394:
1833:)-terminal domain, and the intervening domain (Int-D). The catalytic region is linked to TPR repeats by a translational helix (H3), which loops from the
1039:
1020:
211:
4069:
4064:
2818:"Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes"
2079:
4429:
1709:
phosphorylation (at serine 307 and serine 632/635), reducing insulin signaling, and glycosylating components of insulin signals. Additionally,
2299:
2149:, and proteasomal degradation. Also, there is competitive regulation between OGT and kinase for the protein to attach to a phosphate group or
2281:
4882:
3711:
2991:"Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression"
375:
3757:
2092:-phosphatase occur next to each other and can influence the turnover or function of proteins reciprocally. The G circle represents an
1270:
1263:
4467:
4310:
2201:
352:
1770:
repeats (TPRs); the 13th repeat is truncated. These subunits are dimerized by TPR repeats 6 and 7. OGT is highly expressed in the
1590:
4320:
3086:"The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny"
2366:
1654:-GlcNAcylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the
4341:
2268:
2247:
1362:
1557:
4325:
1734:
1533:
4623:
2264:
1693:-GlcNAc transferase is a part of a host of biological functions within the human body. OGT is involved in the resistance of
3480:
Hart GW, Housley MP, Slawson C (April 2007). "Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins".
2192:-GlcNacylation in the brain along with protein phosphatase could deter this process and improve brain glucose metabolism.
274:
249:
54:
3750:
2243:
3860:
191:
4767:
Wulff-Fuentes E, Berendt RR, Massman L, Danner L, Malard F, Vora J, Kahsay R, Olivier-Van
Stichelen S (January 2021).
3845:
3261:"Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT"
4738:
4285:
2398:"Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum"
388:
287:
4608:
4724:
4711:
4698:
4685:
4672:
4659:
4646:
4410:
4302:
4215:
3850:
3790:
2052:
1551:
4618:
3202:"Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway"
381:
280:
4572:
4515:
3855:
3828:
3781:
3736:
2445:
Clarke AJ, Hurtado-Guerrero R, Pathak S, SchĂĽttelkopf AW, Borodkin V, Shepherd SM, et al. (October 2008).
2142:
1825:
substrate has been researched. The OGT-UDP complex contains three domains in its catalytic region: the amino (
1456:
1342:
1084:
199:
1538:
3702:- A curated database for protein O-GlcNAcylation and referencing more than 14 000 protein entries and 10 000
4520:
4345:
3908:
2177:
2056:
1065:
2661:"Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals"
2324:"O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats"
3823:
3593:
Love DC, Hanover JA (November 2005). "The hexosamine signaling pathway: deciphering the "O-GlcNAc code"".
2217:
1842:
1602:
2161:-GlcNAc has been defined as a negative transcription regulator in response to steroid hormone signaling.
1526:
4541:
4460:
4389:
3875:
3865:
3732:
1655:
4613:
2893:"Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease"
1872:
4784:
4257:
4084:
3818:
3649:
3547:
3489:
3272:
3213:
3156:
3097:
3042:
2772:
2615:
263:
182:, HRNT1, O-GLCNAC, HINCUT-1, O-linked N-acetylglucosamine (GlcNAc) transferase, OGT1, MRX106, XLID106
1554:
178:
4577:
4219:
4134:
4032:
3805:
3777:
3536:"O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability"
2209:
2146:
1818:
1726:
1680:
1620:
1478:
1242:
1187:
2096:-acetylglucosamine group, and the P circle represents a phosphate group. Figure adapted from Hart.
4510:
4372:
4056:
3794:
3618:
3513:
3066:
2003:
of OGT enzymatic activity have been reported. OGT inhibition results in global downregulation of
1956:
223:
3638:"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1"
1246:
1221:
1217:
1191:
1166:
1162:
1158:
1154:
4887:
4859:
4810:
4414:
3840:
3742:
3675:
3610:
3575:
3505:
3459:
3410:
3358:
3306:
3288:
3241:
3182:
3125:
3058:
3012:
2971:
2922:
2849:
2798:
2741:
2692:
2641:
2569:
2525:
2476:
2427:
2345:
1767:
1738:
1545:
171:
47:
4830:"Automatization and self-maintenance of the O-GlcNAcome catalog: a smart scientific database"
2759:
Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, et al. (November 2011).
2710:
Gorelik A, Bartual SG, Borodkin VS, Varghese J, Ferenbach AT, van Aalten DM (November 2019).
4892:
4849:
4841:
4800:
4792:
4556:
4551:
4525:
4453:
4252:
4239:
3883:
3833:
3665:
3657:
3602:
3565:
3555:
3497:
3449:
3441:
3428:
Martin SE, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, et al. (October 2018).
3400:
3392:
3348:
3340:
3296:
3280:
3231:
3221:
3172:
3164:
3115:
3105:
3050:
3002:
2961:
2953:
2912:
2904:
2839:
2829:
2788:
2780:
2731:
2723:
2682:
2672:
2631:
2623:
2559:
2515:
2507:
2466:
2458:
2417:
2409:
2335:
2173:
2032:
2007:-GlcNAc. Cells appear to upregulate OGT and downregulate OGA in response to OGT inhibition.
2000:
1952:
1814:
1514:
468:
399:
343:
298:
4124:
4119:
640:
626:
4603:
4587:
4500:
4271:
1810:
1783:
1763:
1647:
1490:
443:
3379:
Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, et al. (June 2015).
2496:"Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis"
1461:
219:
4788:
3653:
3636:
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. (May 2009).
3551:
3493:
3276:
3217:
3200:
Daou S, Mashtalir N, Hammond-Martel I, Pak H, Yu H, Sui G, et al. (February 2011).
3160:
3101:
3046:
2776:
2619:
633:
4854:
4829:
4805:
4768:
4752:
4641:
4582:
3670:
3637:
3454:
3429:
3405:
3380:
3353:
3328:
3301:
3260:
3236:
3201:
3177:
3144:
2917:
2892:
2844:
2817:
2793:
2760:
2736:
2711:
2687:
2660:
2636:
2603:
2520:
2495:
2471:
2446:
2422:
2397:
1573:
4828:
Malard F, Wulff-Fuentes E, Berendt RR, Didier G, Olivier-Van
Stichelen S (July 2021).
3329:"Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells"
3007:
2990:
2966:
2941:
2564:
2547:
2494:
Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM (April 2006).
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
4876:
4546:
4505:
4276:
3813:
3719:
3570:
3535:
3120:
3085:
1722:
1714:
1676:
669:
3622:
3259:
Meek RW, Blaza JN, Busmann JA, Alteen MG, Vocadlo DJ, Davies GJ (11 November 2021).
3084:
Shafi R, Iyer SP, Ellies LG, O'Donnell N, Marek KW, Chui D, et al. (May 2000).
3070:
203:
4495:
3715:
3710:
3517:
2108:
1698:
461:
240:
2604:"Structure of human O-GlcNAc transferase and its complex with a peptide substrate"
1951:
First, the hydroxyl group of serine is deprotonated by histidine 498, a catalytic
2891:
Liu F, Shi J, Tanimukai H, Gu J, Gu J, Grundke-Iqbal I, et al. (July 2009).
227:
4719:
4654:
4490:
3773:
3327:
Gloster TM, Zandberg WF, Heinonen JE, Shen DL, Deng L, Vocadlo DJ (March 2011).
2712:"Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation"
2304:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2286:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2064:
1964:
1705:
by inhibiting the
Threonine 308 phosphorylation of AKT1, increasing the rate of
1660:
935:
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
4845:
4796:
4747:
3540:
Proceedings of the
National Academy of Sciences of the United States of America
3396:
3284:
3206:
Proceedings of the
National Academy of Sciences of the United States of America
3090:
Proceedings of the
National Academy of Sciences of the United States of America
2874:
2816:
Whelan SA, Dias WB, Thiruneelakantapillai L, Lane MD, Hart GW (February 2010).
2111:, which can increase the turnover of proteins such as the tumor repressor p53.
544:
2727:
2154:
2123:
1759:
1702:
360:
257:
207:
30:
3606:
3292:
2511:
2180:
and regulates gene transcription. Additionally, increasing levels of OGT for
4693:
4667:
3661:
3430:"Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors"
3226:
2834:
2677:
2447:"Structural insights into mechanism and specificity of O-GlcNAc transferase"
2413:
2340:
2323:
2168:-GlcNAc transferase interacts directly with the Ten eleven translocation 2 (
1980:
1865:-acetylglucosamine, and a peptide chain with a reactive serine or threonine
1635:
984:
604:
482:
427:
414:
326:
313:
215:
4863:
4814:
3679:
3614:
3579:
3560:
3509:
3463:
3414:
3362:
3310:
3245:
3186:
3129:
3110:
3062:
3016:
2975:
2926:
2908:
2853:
2802:
2745:
2696:
2645:
2529:
2480:
2462:
2431:
1955:
in this proposed reaction. Lysine 842 is also present to stabilize the UDP
2573:
2349:
1310:
1305:
3445:
3344:
1866:
1787:
1771:
1643:
1502:
1356:
1345:
1294:
1129:
1110:
3501:
3168:
3054:
2784:
2627:
1741:, however the specific function of this modification is mostly unknown.
4434:
4292:
4025:
4020:
4015:
4010:
4005:
3973:
3897:
2957:
2141:
This regulation is important for multiple cellular processes including
2119:
2060:
1869:
group. The proposed reaction is an ordered sequential bi-bi mechanism.
1822:
1802:
1694:
1521:
1366:
1096:
1051:
1809:-GlcNAc transferase has not been well studied, but the structure of a
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
4706:
4476:
4230:
4000:
3995:
3990:
3985:
3980:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3926:
3921:
3916:
2104:
2043:-GlcNAc has some non-specific effects on cell-surface glycosylation.
1976:
1960:
1631:
1585:
1497:
1485:
1473:
1338:
1278:
1006:
3534:
Yang X, Su K, Roos MD, Chang Q, Paterson AJ, Kudlow JE (June 2001).
1983:
and histidine 498. This mechanism is spurred by OGT gene containing
2940:
Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003).
4680:
4382:
4377:
4350:
4201:
4152:
4147:
3709:
2135:
2078:
2068:
1871:
1795:
1779:
1775:
1684:
3145:"TET2 promotes histone O-GlcNAcylation during gene transcription"
2761:"GlcNAcylation of histone H2B facilitates its monoubiquitination"
969:
965:
4196:
4191:
4186:
4181:
4176:
4171:
4164:
4159:
4114:
4109:
4104:
4099:
4094:
4089:
4079:
4074:
4046:
4041:
4036:
2169:
1791:
1725:, and that OGT is necessary for intracellular glycosylation and
1721:-acetylglucosamine. Studies show that OGT alleles are vital for
1706:
1672:
1668:
1664:
1509:
1352:
195:
4449:
3894:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
3889:
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
3746:
3695:
649:
2659:
Maynard JC, Burlingame AL, Medzihradszky KF (November 2016).
2602:
Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S (January 2011).
2063:
mimetic. OSMI-2, OSMI-3, and OSMI-4 have negatively charged
4445:
1845:
pattern was obtained for UDP with respect to UDP-GlcNAc.”
1762:
residues, and is a heterotrimer consisting of two 110 kDa
1766:
and one 78 kDa subunit. The 110 kDa subunit contains 13
900:
positive regulation of transcription by RNA polymerase II
451:
3143:
Chen Q, Chen Y, Bian C, Fujiki R, Yu X (January 2013).
2322:
Lubas WA, Frank DW, Krause M, Hanover JA (April 1997).
4143:
Dolichyl-phosphate-mannose-protein mannosyltransferase
3381:"A small molecule that inhibits OGT activity in cells"
2126:
biosynthetic pathway. OGT catalyzes attachment of the
1963:
ion then attacks the sugar-phosphate bond between the
1717:
of serine and threonine residues with the addition of
4736:
616:
2875:"O15294 (OGT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot"
723:
histone acetyltransferase activity (H4-K16 specific)
4632:
4596:
4565:
4534:
4483:
4409:
4365:
4334:
4301:
4238:
4229:
4214:
4133:
4055:
3907:
3874:
3804:
3789:
2114:The post-translational modification of proteins by
1646:residues of nucleocytoplasmic proteins. Since both
1596:
1584:
1572:
1567:
1544:
1532:
1520:
1508:
1496:
1484:
1472:
1467:
1455:
1450:
1442:
1235:
1210:
1180:
1147:
708:
histone acetyltransferase activity (H4-K5 specific)
703:
histone acetyltransferase activity (H4-K8 specific)
2396:Banerjee S, Robbins PW, Samuelson J (April 2009).
2260:
2258:
2256:
2239:
2237:
2235:
2546:Haltiwanger RS, Blomberg MA, Hart GW (May 1992).
955:positive regulation of cold-induced thermogenesis
875:positive regulation of histone H3-K27 methylation
398:
297:
925:regulation of transcription by RNA polymerase II
905:regulation of insulin receptor signaling pathway
733:protein N-acetylglucosaminyltransferase activity
728:phosphatidylinositol-3,4,5-trisphosphate binding
3529:
3527:
3475:
3473:
2886:
2884:
2027:-GlcNAc is converted intracellularly into UDP-5
804:protein N-acetylglucosaminyltransferase complex
16:Protein-coding gene in the species Homo sapiens
4316:Hypoxanthine-guanine phosphoribosyltransferase
3726:during a seminar at the US NIH, April 18, 2017
2541:
2539:
2265:GRCm38: Ensembl release 89: ENSMUSG00000034160
1967:and UDP. This results in the splitting of UDP-
1876:Figure 2: The proposed catalytic mechanism of
4461:
3758:
2375:-acetylglucosamine (GlcNAc) transferase (UDP-
2317:
2315:
2313:
2130:-GlcNAc group to serine and threonine, while
1790:. There have been trace amounts found in the
930:negative regulation of protein ubiquitination
840:regulation of Rac protein signal transduction
8:
4425:Beta-galactoside alpha-2,6-sialyltransferase
3028:
3026:
1713:-GlcNAc transferase catalyzes intracellular
4395:Indolylacetylinositol arabinosyltransferase
2244:GRCh38: Ensembl release 89: ENSG00000147162
4468:
4454:
4446:
4235:
4226:
3801:
3765:
3751:
3743:
2869:
2867:
2865:
2863:
2597:
2595:
2593:
2591:
2589:
2587:
2585:
2583:
1564:
980:
665:
439:
338:
235:
65:
4853:
4804:
3735:at the U.S. National Library of Medicine
3669:
3569:
3559:
3453:
3404:
3352:
3300:
3235:
3225:
3176:
3119:
3109:
3006:
2965:
2916:
2843:
2833:
2792:
2735:
2716:Nature Structural & Molecular Biology
2686:
2676:
2635:
2563:
2519:
2470:
2421:
2339:
2071:renders these inhibitors cell-permeable.
1884:The chemical reaction can be written as:
3434:Journal of the American Chemical Society
2989:Yang X, Zhang F, Kudlow JE (July 2002).
2361:
2359:
1737:that modifies transcription factors and
1335:O-linked N-acetylglucosaminyltransferase
4759:
4743:
2231:
1733:-GlcNAc transferase also catalyzes the
1619:OGT catalyzes the addition of a single
890:phosphatidylinositol-mediated signaling
845:circadian regulation of gene expression
4773:-GlcNAcome database and meta-analysis"
4430:Monosialoganglioside sialyltransferase
4267:NAD(P):arginine ADP-ribosyltransferase
4248:NAD:diphthamide ADP-ribosyltransferase
1975:-acetylglucosamine – peptide and UDP.
1439:
693:acetylglucosaminyltransferase activity
20:
3374:
3372:
3322:
3320:
713:protein O-GlcNAc transferase activity
403:
364:
359:
302:
261:
256:
7:
1355:. OGT catalyzes the addition of the
2822:The Journal of Biological Chemistry
2665:Molecular & Cellular Proteomics
2552:The Journal of Biological Chemistry
2328:The Journal of Biological Chemistry
1348:) that in humans is encoded by the
2188:-GlcNCAcylation. Replenishing tau
1232:
1207:
1177:
1144:
1120:
1101:
1075:
1056:
1030:
1011:
870:positive regulation of proteolysis
621:
539:
477:
456:
14:
4311:Adenine phosphoribosyltransferase
2383:-acetylglucosaminyl transferase)"
2051:OSMI-1 was first identified from
1404:-acetylglucosamine:polypeptide β-
769:histone acetyltransferase complex
4746:
4321:Uracil phosphoribosyltransferase
1829:)-terminal domain, the carboxy (
850:regulation of glycolytic process
639:
632:
625:
387:
380:
374:
351:
286:
279:
273:
248:
29:
4342:Purine nucleoside phosphorylase
3720:The split personality of human
2379:-acetylglucosamine:polypeptide-
1363:post-translational modification
4326:Amidophosphoribosyltransferase
1735:posttranslational modification
1408:-acetylglucosaminyltransferase
1397:-acetylglucosaminyltransferase
835:protein O-linked glycosylation
650:More reference expression data
605:More reference expression data
1:
3008:10.1016/S0092-8674(02)00810-3
2565:10.1016/S0021-9258(19)50380-5
945:regulation of gluconeogenesis
372:
271:
3861:Ceramide glucosyltransferase
3733:Protein+O-GlcNAc+transferase
2033:substrate analogue inhibitor
1979:transfers take place at the
1758:The human OGT gene has 1046
830:histone H3-K4 trimethylation
698:glycosyltransferase activity
4883:Genes on human chromosome X
1853:The molecular mechanism of
4909:
4797:10.1038/s41597-021-00810-4
4286:Poly ADP ribose polymerase
3397:10.1021/acschembio.5b00004
3285:10.1038/s41467-021-26796-6
1774:and also expressed in the
1432:-glucosaminyl transferase
880:histone H4-K16 acetylation
789:protein-containing complex
4624:Michaelis–Menten kinetics
4303:Phosphoribosyltransferase
2728:10.1038/s41594-019-0325-8
2300:"Mouse PubMed Reference:"
2282:"Human PubMed Reference:"
2172:) enzyme, which converts
2057:fluorescence polarization
2053:high-throughput screening
1563:
1309:
1304:
1300:
1293:
1277:
1271:Chr X: 100.68 – 100.73 Mb
1258:
1239:
1214:
1203:
1184:
1151:
1140:
1127:
1123:
1108:
1104:
1095:
1082:
1078:
1063:
1059:
1050:
1037:
1033:
1018:
1014:
1005:
990:
983:
979:
963:
885:histone H4-K8 acetylation
855:histone H4-K5 acetylation
668:
664:
647:
624:
615:
602:
555:medullary collecting duct
551:
542:
517:epithelium of nasopharynx
489:
480:
450:
442:
438:
421:
408:
371:
350:
341:
337:
320:
307:
270:
247:
238:
234:
189:
186:
176:
169:
164:
73:
68:
51:
46:
41:
37:
28:
23:
4846:10.1093/database/baab039
4516:Diffusion-limited enzyme
3856:1,3-Beta-glucan synthase
3737:Medical Subject Headings
3607:10.1126/stke.3122005re13
2512:10.1038/sj.emboj.7601026
1971:-acetylglucosamine into
915:protein deubiquitination
4346:Thymidine phosphorylase
3662:10.1126/science.1170116
3333:Nature Chemical Biology
3227:10.1073/pnas.1013822108
2946:Genes & Development
2835:10.1074/jbc.M109.077818
2678:10.1074/mcp.M116.061549
2341:10.1074/jbc.272.14.9316
2178:5-hydroxymethylcytosine
1813:complex with UDP and a
1642:-glycosidic linkage to
1630:-glycosidic linkage to
1264:Chr X: 71.53 – 71.58 Mb
794:mitochondrial membranes
4240:ADP-ribosyltransferase
3728:
3561:10.1073/pnas.111099998
3111:10.1073/pnas.100471497
2463:10.1038/emboj.2008.186
2118:-GlcNAc is spurred by
2097:
1931:-threonine → UDP + -3-
1881:
1849:Mechanism of catalysis
1843:competitive inhibition
940:chromatin organization
4609:Eadie–Hofstee diagram
4542:Allosteric regulation
4390:Arabinosyltransferase
3866:N-glycosyltransferase
3713:
3265:Nature Communications
2414:10.1093/glycob/cwn107
2221:-linked glycosylation
2082:
1875:
1412:Systematic name: UDP-
1377:Other names include:
865:protein glycosylation
493:middle temporal gyrus
4619:Lineweaver–Burk plot
4258:Pseudomonas exotoxin
3778:glycosyltransferases
3446:10.1021/jacs.8b07328
3385:ACS Chemical Biology
3345:10.1038/nchembio.520
2909:10.1093/brain/awp099
820:response to nutrient
688:transferase activity
366:X chromosome (mouse)
264:X chromosome (human)
69:List of PDB id codes
42:Available structures
4789:2021NatSD...8...25W
4033:Hyaluronan synthase
3724:-GlcNAc transferase
3654:2009Sci...324..930T
3552:2001PNAS...98.6611Y
3502:10.1038/nature05815
3494:2007Natur.446.1017H
3440:(42): 13542–13545.
3277:2021NatCo..12.6508M
3218:2011PNAS..108.2747D
3169:10.1038/nature11742
3161:2013Natur.493..561C
3102:2000PNAS...97.5735S
3055:10.1038/nature06668
3047:2008Natur.451..964Y
2785:10.1038/nature10656
2777:2011Natur.480..557F
2628:10.1038/nature09638
2620:2011Natur.469..564L
2147:signal transduction
1900:-serine → UDP + -3-
1837:-cat domain to the
1727:embryonic stem cell
1681:Host cell factor C1
1615:Glycosyltransferase
1446:-GlcNAc transferase
1384:-GlcNAc transferase
1327:-GlcNAc transferase
895:signal transduction
860:response to insulin
4578:Enzyme superfamily
4511:Enzyme promiscuity
4373:Xylosyltransferase
3846:Debranching enzyme
3729:
2958:10.1101/gad.252103
2367:"Entrez Gene: OGT
2164:Studies show that
2098:
1882:
1624:-acetylglucosamine
1400:Uridine diphospho-
1085:ENSMUSG00000034160
920:protein processing
813:Biological process
742:Cellular component
676:Molecular function
591:lobe of cerebellum
505:right uterine tube
4834:Database (Oxford)
4734:
4733:
4443:
4442:
4405:
4404:
4361:
4360:
4210:
4209:
3841:Glycogen synthase
3727:
3488:(7139): 1017–22.
2903:(Pt 7): 1820–32.
2722:(11): 1071–1077.
2671:(11): 3405–3411.
2134:-GlcNAcase spurs
2122:flux through the
1946:
1942:
1930:
1926:
1915:
1911:
1899:
1895:
1768:tetratricopeptide
1739:RNA polymerase II
1612:
1611:
1608:
1607:
1527:metabolic pathway
1320:
1319:
1316:
1315:
1289:
1288:
1254:
1253:
1229:
1228:
1199:
1198:
1174:
1173:
1136:
1135:
1117:
1116:
1091:
1090:
1072:
1071:
1046:
1045:
1027:
1026:
975:
974:
910:apoptotic process
660:
659:
656:
655:
611:
610:
598:
597:
579:cerebellar cortex
536:
535:
434:
433:
333:
332:
160:
159:
156:
155:
52:Ortholog search:
4900:
4868:
4867:
4857:
4825:
4819:
4818:
4808:
4764:
4751:
4750:
4742:
4614:Hanes–Woolf plot
4557:Enzyme activator
4552:Enzyme inhibitor
4526:Enzyme catalysis
4470:
4463:
4456:
4447:
4253:Diphtheria toxin
4236:
4227:
3884:Lactose synthase
3851:Branching enzyme
3802:
3767:
3760:
3753:
3744:
3714:
3700:-GlcNAc Database
3684:
3683:
3673:
3633:
3627:
3626:
3590:
3584:
3583:
3573:
3563:
3531:
3522:
3521:
3477:
3468:
3467:
3457:
3425:
3419:
3418:
3408:
3376:
3367:
3366:
3356:
3324:
3315:
3314:
3304:
3256:
3250:
3249:
3239:
3229:
3197:
3191:
3190:
3180:
3140:
3134:
3133:
3123:
3113:
3081:
3075:
3074:
3030:
3021:
3020:
3010:
2986:
2980:
2979:
2969:
2937:
2931:
2930:
2920:
2888:
2879:
2878:
2871:
2858:
2857:
2847:
2837:
2813:
2807:
2806:
2796:
2771:(7378): 557–60.
2756:
2750:
2749:
2739:
2707:
2701:
2700:
2690:
2680:
2656:
2650:
2649:
2639:
2599:
2578:
2577:
2567:
2543:
2534:
2533:
2523:
2500:The EMBO Journal
2491:
2485:
2484:
2474:
2451:The EMBO Journal
2442:
2436:
2435:
2425:
2393:
2387:
2386:
2363:
2354:
2353:
2343:
2319:
2308:
2307:
2296:
2290:
2289:
2278:
2272:
2262:
2251:
2241:
2213:-GlcNAcase (OGA)
2174:5-methylcytosine
1944:
1940:
1928:
1927:-glucosamine + -
1924:
1913:
1909:
1897:
1896:-glucosamine + -
1893:
1565:
1440:
1431:
1420:-glucosamine:-3-
1419:
1302:
1301:
1273:
1266:
1249:
1233:
1224:
1208:
1204:RefSeq (protein)
1194:
1178:
1169:
1145:
1121:
1102:
1076:
1057:
1031:
1012:
981:
825:rhythmic process
666:
652:
643:
636:
629:
622:
607:
559:genital tubercle
547:
545:Top expressed in
540:
497:Brodmann area 23
485:
483:Top expressed in
478:
457:
440:
430:
417:
406:
391:
384:
378:
367:
355:
339:
329:
316:
305:
290:
283:
277:
266:
252:
236:
230:
181:
174:
151:
66:
60:
39:
38:
33:
21:
4908:
4907:
4903:
4902:
4901:
4899:
4898:
4897:
4873:
4872:
4871:
4827:
4826:
4822:
4777:Scientific Data
4766:
4765:
4761:
4757:
4745:
4737:
4735:
4730:
4642:Oxidoreductases
4628:
4604:Enzyme kinetics
4592:
4588:List of enzymes
4561:
4530:
4501:Catalytic triad
4479:
4474:
4444:
4439:
4416:
4401:
4357:
4330:
4297:
4272:Pertussis toxin
4221:
4206:
4129:
4051:
3903:
3870:
3796:
3785:
3771:
3692:
3687:
3648:(5929): 930–5.
3635:
3634:
3630:
3592:
3591:
3587:
3533:
3532:
3525:
3479:
3478:
3471:
3427:
3426:
3422:
3378:
3377:
3370:
3326:
3325:
3318:
3258:
3257:
3253:
3199:
3198:
3194:
3155:(7433): 561–4.
3142:
3141:
3137:
3083:
3082:
3078:
3041:(7181): 964–9.
3032:
3031:
3024:
2988:
2987:
2983:
2939:
2938:
2934:
2890:
2889:
2882:
2873:
2872:
2861:
2815:
2814:
2810:
2758:
2757:
2753:
2709:
2708:
2704:
2658:
2657:
2653:
2614:(7331): 564–7.
2601:
2600:
2581:
2558:(13): 9005–13.
2545:
2544:
2537:
2493:
2492:
2488:
2444:
2443:
2439:
2395:
2394:
2390:
2365:
2364:
2357:
2334:(14): 9316–24.
2321:
2320:
2311:
2298:
2297:
2293:
2280:
2279:
2275:
2263:
2254:
2242:
2233:
2229:
2198:
2077:
2049:
2022:
2017:
1997:
1943:-glucosaminyl)-
1912:-glucosaminyl)-
1851:
1784:skeletal muscle
1756:
1747:
1648:phosphorylation
1617:
1438:
1429:
1417:
1375:
1311:View/Edit Mouse
1306:View/Edit Human
1269:
1262:
1259:Location (UCSC)
1245:
1241:
1220:
1216:
1190:
1186:
1165:
1161:
1157:
1153:
1066:ENSG00000147162
959:
808:
799:cell projection
759:plasma membrane
737:
718:protein binding
648:
638:
637:
631:
630:
603:
594:
589:
585:
583:dorsal striatum
581:
577:
573:
569:
565:
561:
557:
543:
532:
529:trabecular bone
527:
525:parietal pleura
523:
519:
515:
513:visceral pleura
511:
507:
503:
499:
495:
481:
425:
412:
404:
394:
393:
392:
385:
365:
342:Gene location (
324:
311:
303:
293:
292:
291:
284:
262:
239:Gene location (
228:OGT - orthologs
190:
177:
170:
75:
53:
17:
12:
11:
5:
4906:
4904:
4896:
4895:
4890:
4885:
4875:
4874:
4870:
4869:
4820:
4758:
4756:
4755:
4732:
4731:
4729:
4728:
4715:
4702:
4689:
4676:
4663:
4650:
4636:
4634:
4630:
4629:
4627:
4626:
4621:
4616:
4611:
4606:
4600:
4598:
4594:
4593:
4591:
4590:
4585:
4580:
4575:
4569:
4567:
4566:Classification
4563:
4562:
4560:
4559:
4554:
4549:
4544:
4538:
4536:
4532:
4531:
4529:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4487:
4485:
4481:
4480:
4475:
4473:
4472:
4465:
4458:
4450:
4441:
4440:
4438:
4437:
4432:
4427:
4421:
4419:
4407:
4406:
4403:
4402:
4400:
4399:
4398:
4397:
4387:
4386:
4385:
4380:
4369:
4367:
4363:
4362:
4359:
4358:
4356:
4355:
4354:
4353:
4338:
4336:
4332:
4331:
4329:
4328:
4323:
4318:
4313:
4307:
4305:
4299:
4298:
4296:
4295:
4289:
4288:
4282:
4281:
4280:
4279:
4274:
4263:
4262:
4261:
4260:
4255:
4244:
4242:
4233:
4224:
4212:
4211:
4208:
4207:
4205:
4204:
4199:
4194:
4189:
4184:
4179:
4174:
4168:
4167:
4162:
4157:
4156:
4155:
4150:
4139:
4137:
4131:
4130:
4128:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4061:
4059:
4053:
4052:
4050:
4049:
4044:
4039:
4029:
4028:
4023:
4018:
4013:
4008:
4003:
3998:
3993:
3988:
3983:
3977:
3976:
3971:
3966:
3961:
3956:
3951:
3946:
3941:
3936:
3930:
3929:
3924:
3919:
3913:
3911:
3905:
3904:
3902:
3901:
3891:
3886:
3880:
3878:
3872:
3871:
3869:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3837:
3836:
3831:
3826:
3821:
3810:
3808:
3799:
3787:
3786:
3772:
3770:
3769:
3762:
3755:
3747:
3741:
3740:
3716:Suzanne Walker
3708:
3707:
3706:-GlcNAc sites.
3691:
3690:External links
3688:
3686:
3685:
3628:
3595:Science's STKE
3585:
3546:(12): 6611–6.
3523:
3469:
3420:
3368:
3316:
3251:
3212:(7): 2747–52.
3192:
3135:
3096:(11): 5735–9.
3076:
3022:
2981:
2952:(7): 896–911.
2932:
2880:
2859:
2828:(8): 5204–11.
2808:
2751:
2702:
2651:
2579:
2535:
2506:(7): 1569–78.
2486:
2457:(20): 2780–8.
2437:
2388:
2355:
2309:
2291:
2273:
2252:
2230:
2228:
2225:
2224:
2223:
2215:
2207:
2197:
2194:
2076:
2073:
2069:esterification
2048:
2045:
2020:
2016:
2009:
1996:
1993:
1949:
1948:
1917:
1850:
1847:
1755:
1752:
1746:
1743:
1671:, KMT2E/MLL5,
1616:
1613:
1610:
1609:
1606:
1605:
1600:
1594:
1593:
1588:
1582:
1581:
1576:
1570:
1569:
1561:
1560:
1549:
1542:
1541:
1536:
1530:
1529:
1524:
1518:
1517:
1512:
1506:
1505:
1500:
1494:
1493:
1488:
1482:
1481:
1476:
1470:
1469:
1465:
1464:
1459:
1453:
1452:
1448:
1447:
1437:
1434:
1410:
1409:
1398:
1388:
1385:
1374:
1371:
1329:also known as
1318:
1317:
1314:
1313:
1308:
1298:
1297:
1291:
1290:
1287:
1286:
1284:
1282:
1275:
1274:
1267:
1260:
1256:
1255:
1252:
1251:
1237:
1236:
1230:
1227:
1226:
1212:
1211:
1205:
1201:
1200:
1197:
1196:
1182:
1181:
1175:
1172:
1171:
1149:
1148:
1142:
1138:
1137:
1134:
1133:
1125:
1124:
1118:
1115:
1114:
1106:
1105:
1099:
1093:
1092:
1089:
1088:
1080:
1079:
1073:
1070:
1069:
1061:
1060:
1054:
1048:
1047:
1044:
1043:
1035:
1034:
1028:
1025:
1024:
1016:
1015:
1009:
1003:
1002:
997:
992:
988:
987:
977:
976:
973:
972:
961:
960:
958:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
816:
814:
810:
809:
807:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
745:
743:
739:
738:
736:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
662:
661:
658:
657:
654:
653:
645:
644:
619:
613:
612:
609:
608:
600:
599:
596:
595:
593:
592:
588:
584:
580:
576:
572:
571:olfactory bulb
568:
564:
560:
556:
552:
549:
548:
537:
534:
533:
531:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
487:
486:
474:
473:
465:
454:
448:
447:
444:RNA expression
436:
435:
432:
431:
423:
419:
418:
410:
407:
402:
396:
395:
386:
379:
373:
369:
368:
363:
357:
356:
348:
347:
335:
334:
331:
330:
322:
318:
317:
309:
306:
301:
295:
294:
285:
278:
272:
268:
267:
260:
254:
253:
245:
244:
232:
231:
188:
184:
183:
175:
167:
166:
162:
161:
158:
157:
154:
153:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
4905:
4894:
4891:
4889:
4886:
4884:
4881:
4880:
4878:
4865:
4861:
4856:
4851:
4847:
4843:
4839:
4835:
4831:
4824:
4821:
4816:
4812:
4807:
4802:
4798:
4794:
4790:
4786:
4782:
4778:
4774:
4772:
4763:
4760:
4754:
4749:
4744:
4740:
4726:
4722:
4721:
4716:
4713:
4709:
4708:
4703:
4700:
4696:
4695:
4690:
4687:
4683:
4682:
4677:
4674:
4670:
4669:
4664:
4661:
4657:
4656:
4651:
4648:
4644:
4643:
4638:
4637:
4635:
4631:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4601:
4599:
4595:
4589:
4586:
4584:
4583:Enzyme family
4581:
4579:
4576:
4574:
4571:
4570:
4568:
4564:
4558:
4555:
4553:
4550:
4548:
4547:Cooperativity
4545:
4543:
4540:
4539:
4537:
4533:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4506:Oxyanion hole
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4488:
4486:
4482:
4478:
4471:
4466:
4464:
4459:
4457:
4452:
4451:
4448:
4436:
4433:
4431:
4428:
4426:
4423:
4422:
4420:
4418:
4412:
4408:
4396:
4393:
4392:
4391:
4388:
4384:
4381:
4379:
4376:
4375:
4374:
4371:
4370:
4368:
4364:
4352:
4349:
4348:
4347:
4343:
4340:
4339:
4337:
4333:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4308:
4306:
4304:
4300:
4294:
4291:
4290:
4287:
4284:
4283:
4278:
4277:Cholera toxin
4275:
4273:
4270:
4269:
4268:
4265:
4264:
4259:
4256:
4254:
4251:
4250:
4249:
4246:
4245:
4243:
4241:
4237:
4234:
4232:
4228:
4225:
4223:
4217:
4213:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4169:
4166:
4163:
4161:
4158:
4154:
4151:
4149:
4146:
4145:
4144:
4141:
4140:
4138:
4136:
4132:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4062:
4060:
4058:
4054:
4048:
4045:
4043:
4040:
4038:
4034:
4031:
4030:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3978:
3975:
3972:
3970:
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3931:
3928:
3925:
3923:
3920:
3918:
3915:
3914:
3912:
3910:
3909:Glucuronosyl-
3906:
3899:
3895:
3892:
3890:
3887:
3885:
3882:
3881:
3879:
3877:
3873:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3816:
3815:
3814:Phosphorylase
3812:
3811:
3809:
3807:
3803:
3800:
3798:
3792:
3788:
3783:
3779:
3775:
3768:
3763:
3761:
3756:
3754:
3749:
3748:
3745:
3738:
3734:
3731:
3730:
3725:
3723:
3717:
3712:
3705:
3701:
3699:
3694:
3693:
3689:
3681:
3677:
3672:
3667:
3663:
3659:
3655:
3651:
3647:
3643:
3639:
3632:
3629:
3624:
3620:
3616:
3612:
3608:
3604:
3601:(312): re13.
3600:
3596:
3589:
3586:
3581:
3577:
3572:
3567:
3562:
3557:
3553:
3549:
3545:
3541:
3537:
3530:
3528:
3524:
3519:
3515:
3511:
3507:
3503:
3499:
3495:
3491:
3487:
3483:
3476:
3474:
3470:
3465:
3461:
3456:
3451:
3447:
3443:
3439:
3435:
3431:
3424:
3421:
3416:
3412:
3407:
3402:
3398:
3394:
3391:(6): 1392–7.
3390:
3386:
3382:
3375:
3373:
3369:
3364:
3360:
3355:
3350:
3346:
3342:
3339:(3): 174–81.
3338:
3334:
3330:
3323:
3321:
3317:
3312:
3308:
3303:
3298:
3294:
3290:
3286:
3282:
3278:
3274:
3270:
3266:
3262:
3255:
3252:
3247:
3243:
3238:
3233:
3228:
3223:
3219:
3215:
3211:
3207:
3203:
3196:
3193:
3188:
3184:
3179:
3174:
3170:
3166:
3162:
3158:
3154:
3150:
3146:
3139:
3136:
3131:
3127:
3122:
3117:
3112:
3107:
3103:
3099:
3095:
3091:
3087:
3080:
3077:
3072:
3068:
3064:
3060:
3056:
3052:
3048:
3044:
3040:
3036:
3029:
3027:
3023:
3018:
3014:
3009:
3004:
3000:
2996:
2992:
2985:
2982:
2977:
2973:
2968:
2963:
2959:
2955:
2951:
2947:
2943:
2936:
2933:
2928:
2924:
2919:
2914:
2910:
2906:
2902:
2898:
2894:
2887:
2885:
2881:
2876:
2870:
2868:
2866:
2864:
2860:
2855:
2851:
2846:
2841:
2836:
2831:
2827:
2823:
2819:
2812:
2809:
2804:
2800:
2795:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2762:
2755:
2752:
2747:
2743:
2738:
2733:
2729:
2725:
2721:
2717:
2713:
2706:
2703:
2698:
2694:
2689:
2684:
2679:
2674:
2670:
2666:
2662:
2655:
2652:
2647:
2643:
2638:
2633:
2629:
2625:
2621:
2617:
2613:
2609:
2605:
2598:
2596:
2594:
2592:
2590:
2588:
2586:
2584:
2580:
2575:
2571:
2566:
2561:
2557:
2553:
2549:
2542:
2540:
2536:
2531:
2527:
2522:
2517:
2513:
2509:
2505:
2501:
2497:
2490:
2487:
2482:
2478:
2473:
2468:
2464:
2460:
2456:
2452:
2448:
2441:
2438:
2433:
2429:
2424:
2419:
2415:
2411:
2407:
2403:
2399:
2392:
2389:
2384:
2382:
2378:
2374:
2370:
2362:
2360:
2356:
2351:
2347:
2342:
2337:
2333:
2329:
2325:
2318:
2316:
2314:
2310:
2305:
2301:
2295:
2292:
2287:
2283:
2277:
2274:
2270:
2266:
2261:
2259:
2257:
2253:
2249:
2245:
2240:
2238:
2236:
2232:
2226:
2222:
2220:
2216:
2214:
2212:
2208:
2206:
2204:
2200:
2199:
2195:
2193:
2191:
2187:
2183:
2179:
2175:
2171:
2167:
2162:
2160:
2156:
2152:
2148:
2144:
2143:transcription
2139:
2137:
2133:
2129:
2125:
2121:
2117:
2112:
2110:
2106:
2102:
2095:
2091:
2087:
2081:
2074:
2072:
2070:
2066:
2062:
2058:
2054:
2046:
2044:
2042:
2038:
2035:of OGT. UDP-5
2034:
2030:
2026:
2014:
2010:
2008:
2006:
2002:
1994:
1992:
1990:
1986:
1982:
1978:
1974:
1970:
1966:
1962:
1958:
1954:
1938:
1934:
1922:
1918:
1907:
1903:
1891:
1887:
1886:
1885:
1879:
1874:
1870:
1868:
1864:
1860:
1856:
1848:
1846:
1844:
1840:
1836:
1832:
1828:
1824:
1820:
1817:complex with
1816:
1812:
1808:
1805:structure of
1804:
1799:
1797:
1793:
1789:
1785:
1781:
1777:
1773:
1769:
1765:
1761:
1753:
1751:
1744:
1742:
1740:
1736:
1732:
1728:
1724:
1723:embryogenesis
1720:
1716:
1715:glycosylation
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1686:
1682:
1678:
1674:
1670:
1666:
1662:
1657:
1653:
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1623:
1614:
1604:
1601:
1599:
1595:
1592:
1589:
1587:
1583:
1580:
1577:
1575:
1571:
1566:
1562:
1559:
1556:
1553:
1550:
1547:
1543:
1540:
1537:
1535:
1531:
1528:
1525:
1523:
1519:
1516:
1513:
1511:
1507:
1504:
1503:NiceZyme view
1501:
1499:
1495:
1492:
1489:
1487:
1483:
1480:
1477:
1475:
1471:
1466:
1463:
1460:
1458:
1454:
1449:
1445:
1441:
1435:
1433:
1427:
1423:
1415:
1407:
1403:
1399:
1396:
1392:
1389:
1386:
1383:
1380:
1379:
1378:
1372:
1370:
1368:
1364:
1361:
1359:
1354:
1351:
1347:
1344:
1340:
1336:
1332:
1328:
1326:
1312:
1307:
1303:
1299:
1296:
1292:
1285:
1283:
1280:
1276:
1272:
1268:
1265:
1261:
1257:
1250:
1248:
1244:
1238:
1234:
1231:
1225:
1223:
1219:
1213:
1209:
1206:
1202:
1195:
1193:
1189:
1183:
1179:
1176:
1170:
1168:
1164:
1160:
1156:
1150:
1146:
1143:
1141:RefSeq (mRNA)
1139:
1132:
1131:
1126:
1122:
1119:
1113:
1112:
1107:
1103:
1100:
1098:
1094:
1087:
1086:
1081:
1077:
1074:
1068:
1067:
1062:
1058:
1055:
1053:
1049:
1042:
1041:
1036:
1032:
1029:
1023:
1022:
1017:
1013:
1010:
1008:
1004:
1001:
998:
996:
993:
989:
986:
982:
978:
971:
967:
962:
956:
953:
951:
950:viral process
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
817:
815:
812:
811:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
764:mitochondrion
762:
760:
757:
755:
752:
750:
747:
746:
744:
741:
740:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
683:lipid binding
681:
680:
678:
675:
674:
671:
670:Gene ontology
667:
663:
651:
646:
642:
635:
628:
623:
620:
618:
614:
606:
601:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
553:
550:
546:
541:
538:
528:
524:
521:skin of thigh
520:
516:
512:
508:
504:
500:
496:
492:
491:
488:
484:
479:
476:
475:
472:
470:
466:
464:
463:
459:
458:
455:
453:
449:
445:
441:
437:
429:
424:
420:
416:
411:
401:
397:
390:
383:
377:
370:
362:
358:
354:
349:
345:
340:
336:
328:
323:
319:
315:
310:
300:
296:
289:
282:
276:
269:
265:
259:
255:
251:
246:
242:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
185:
180:
173:
168:
163:
152:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
4837:
4833:
4823:
4780:
4776:
4770:
4762:
4720:Translocases
4717:
4704:
4691:
4678:
4665:
4655:Transferases
4652:
4639:
4496:Binding site
4417:transferases
4222:transferases
3797:transferases
3774:Transferases
3721:
3703:
3697:
3645:
3641:
3631:
3598:
3594:
3588:
3543:
3539:
3485:
3481:
3437:
3433:
3423:
3388:
3384:
3336:
3332:
3268:
3264:
3254:
3209:
3205:
3195:
3152:
3148:
3138:
3093:
3089:
3079:
3038:
3034:
3001:(1): 69–80.
2998:
2994:
2984:
2949:
2945:
2935:
2900:
2896:
2825:
2821:
2811:
2768:
2764:
2754:
2719:
2715:
2705:
2668:
2664:
2654:
2611:
2607:
2555:
2551:
2503:
2499:
2489:
2454:
2450:
2440:
2408:(4): 331–6.
2405:
2402:Glycobiology
2401:
2391:
2380:
2376:
2372:
2368:
2331:
2327:
2303:
2294:
2285:
2276:
2218:
2210:
2202:
2189:
2185:
2181:
2165:
2163:
2158:
2157:regulation.
2150:
2140:
2131:
2127:
2115:
2113:
2109:glycoprotein
2100:
2099:
2093:
2089:
2088:-GlcNAc and
2085:
2050:
2040:
2036:
2028:
2024:
2018:
2012:
2004:
1998:
1988:
1984:
1972:
1968:
1950:
1936:
1932:
1920:
1905:
1901:
1889:
1883:
1877:
1862:
1858:
1854:
1852:
1838:
1834:
1830:
1826:
1806:
1800:
1757:
1748:
1730:
1718:
1710:
1699:muscle cells
1690:
1689:
1651:
1639:
1627:
1621:
1618:
1491:BRENDA entry
1443:
1425:
1421:
1413:
1411:
1405:
1401:
1394:
1390:
1381:
1376:
1373:Nomenclature
1357:
1349:
1334:
1330:
1324:
1322:
1321:
1243:NP_001277464
1240:
1215:
1188:NM_001290535
1185:
1152:
1128:
1109:
1083:
1064:
1038:
1019:
999:
994:
587:vas deferens
467:
460:
426:100,727,957
413:100,683,666
187:External IDs
74:
18:
4769:"The human
4491:Active site
3876:Galactosyl-
3271:(1): 6508.
2065:carboxylate
2031:-GlcNAc, a
1965:glucosamine
1661:Histone H2B
1626:through an
1479:IntEnz view
1451:Identifiers
784:nucleoplasm
567:granulocyte
501:skin of hip
325:71,575,892
312:71,533,104
165:Identifiers
4877:Categories
4694:Isomerases
4668:Hydrolases
4535:Regulation
3829:Cellobiose
3718:describes
2877:. UniProt.
2271:, May 2017
2250:, May 2017
2227:References
2155:glycolysis
2124:hexosamine
2075:Regulation
2001:inhibitors
1995:Inhibitors
1947:-threonine
1786:, and the
1760:amino acid
1729:vitality.
1703:adipocytes
1548:structures
1515:KEGG entry
1428:-acetyl-β-
1416:-α-acetyl-
471:(ortholog)
405:X|X D
208:HomoloGene
4783:(1): 25.
4573:EC number
4220:Pentosyl-
4135:Mannosyl-
3806:Glucosyl-
3293:2041-1723
2138:removal.
1981:phosphate
1754:Structure
1656:substrate
1636:threonine
1468:Databases
1462:2.4.1.255
1346:2.4.1.255
1247:NP_631883
1222:NP_858059
1218:NP_858058
1192:NM_139144
1167:NM_025192
1163:NM_181673
1159:NM_181672
1155:NM_003605
985:Orthologs
749:cytoplasm
216:GeneCards
4888:EC 2.4.1
4864:34279596
4815:33479245
4597:Kinetics
4521:Cofactor
4484:Activity
4057:Fucosyl-
3824:Glycogen
3795:Hexosyl-
3680:19372391
3623:29082840
3615:16317114
3580:11371615
3510:17460662
3464:30285435
3415:25751766
3363:21258330
3311:34764280
3246:21285374
3187:23222540
3130:10801981
3071:18459576
3063:18288188
3017:12150998
2976:12670868
2927:19451179
2854:20018868
2803:22121020
2746:31695185
2697:27558639
2646:21240259
2530:16541109
2481:18818698
2432:18948359
2371:-linked
2267:–
2246:–
2196:See also
2067:groups;
1987:-linked
1939:-acetyl-
1923:-acetyl-
1908:-acetyl-
1892:-acetyl-
1867:hydroxyl
1857:-linked
1794:and the
1788:placenta
1772:pancreas
1764:subunits
1745:Protease
1644:cysteine
1603:proteins
1591:articles
1579:articles
1552:RCSB PDB
1436:Function
1393:-linked
1367:proteins
1323:Protein
1295:Wikidata
964:Sources:
754:membrane
4893:Enzymes
4855:8288053
4806:7820439
4785:Bibcode
4753:Biology
4707:Ligases
4477:Enzymes
4435:ST8SIA4
4293:Sirtuin
4026:UGT2B28
4021:UGT2B17
4016:UGT2B15
4011:UGT2B11
4006:UGT2B10
3974:UGT1A10
3898:C1GALT1
3671:2715015
3650:Bibcode
3642:Science
3548:Bibcode
3518:4392021
3490:Bibcode
3455:6261342
3406:4475500
3354:3202988
3302:8586251
3273:Bibcode
3237:3041071
3214:Bibcode
3178:3684361
3157:Bibcode
3098:Bibcode
3043:Bibcode
2918:2702834
2845:2820748
2794:7289526
2773:Bibcode
2737:6858883
2688:5098038
2637:3064491
2616:Bibcode
2574:1533623
2521:1440316
2472:2556091
2423:2733775
2350:9083068
2269:Ensembl
2248:Ensembl
2205:-GlcNAc
2120:glucose
2061:uridine
2015:-GlcNAc
1916:-serine
1823:peptide
1815:ternary
1803:crystal
1695:insulin
1638:and an
1539:profile
1522:MetaCyc
1360:-GlcNAc
1097:UniProt
1052:Ensembl
991:Species
970:QuickGO
779:cytosol
774:nucleus
563:utricle
446:pattern
204:1339639
172:Aliases
4862:
4852:
4813:
4803:
4739:Portal
4681:Lyases
4415:Sialyl
4411:2.4.99
4231:Ribose
4070:POFUT2
4065:POFUT1
4001:UGT2B7
3996:UGT2B4
3991:UGT2A3
3986:UGT2A2
3981:UGT2A1
3969:UGT1A9
3964:UGT1A8
3959:UGT1A7
3954:UGT1A6
3949:UGT1A5
3944:UGT1A4
3939:UGT1A3
3934:UGT1A1
3927:B3GAT3
3922:B3GAT2
3917:B3GAT1
3819:Starch
3739:(MeSH)
3678:
3668:
3621:
3613:
3578:
3568:
3516:
3508:
3482:Nature
3462:
3452:
3413:
3403:
3361:
3351:
3309:
3299:
3291:
3244:
3234:
3185:
3175:
3149:Nature
3128:
3118:
3069:
3061:
3035:Nature
3015:
2974:
2967:196026
2964:
2925:
2915:
2852:
2842:
2801:
2791:
2765:Nature
2744:
2734:
2695:
2685:
2644:
2634:
2608:Nature
2572:
2528:
2518:
2479:
2469:
2430:
2420:
2348:
2105:kinase
2055:using
1977:Proton
1961:oxygen
1959:. The
1957:moiety
1821:and a
1811:binary
1683:, and
1632:serine
1586:PubMed
1568:Search
1558:PDBsum
1498:ExPASy
1486:BRENDA
1474:IntEnz
1457:EC no.
1387:OGTase
1339:enzyme
1337:is an
1281:search
1279:PubMed
1130:Q8CGY8
1111:O15294
1040:108155
1007:Entrez
617:BioGPS
304:Xq13.1
196:300255
4840:: 1.
4633:Types
4383:XYLT2
4378:XYLT1
4366:Other
4351:ECGF1
4335:Other
4216:2.4.2
4202:ALG12
4153:POMT2
4148:POMT1
4125:FUT11
4120:FUT10
3791:2.4.1
3619:S2CID
3571:34401
3514:S2CID
3121:18502
3067:S2CID
2897:Brain
2136:sugar
1999:Many
1796:liver
1780:brain
1776:heart
1685:SIN3A
1534:PRIAM
1000:Mouse
995:Human
966:Amigo
509:tibia
469:Mouse
462:Human
409:Start
344:Mouse
308:Start
241:Human
4860:PMID
4838:2021
4811:PMID
4725:list
4718:EC7
4712:list
4705:EC6
4699:list
4692:EC5
4686:list
4679:EC4
4673:list
4666:EC3
4660:list
4653:EC2
4647:list
4640:EC1
4197:ALG9
4192:ALG8
4187:ALG6
4182:ALG3
4177:ALG2
4172:ALG1
4165:DPM3
4160:DPM1
4115:FUT9
4110:FUT8
4105:FUT7
4100:FUT6
4095:FUT5
4090:FUT4
4085:FUT3
4080:FUT2
4075:FUT1
4047:HAS3
4042:HAS2
4037:HAS1
3834:Myo-
3784:2.4)
3696:The
3676:PMID
3611:PMID
3599:2005
3576:PMID
3506:PMID
3460:PMID
3411:PMID
3359:PMID
3307:PMID
3289:ISSN
3242:PMID
3183:PMID
3126:PMID
3059:PMID
3013:PMID
2995:Cell
2972:PMID
2923:PMID
2850:PMID
2799:PMID
2742:PMID
2693:PMID
2642:PMID
2570:PMID
2526:PMID
2477:PMID
2428:PMID
2346:PMID
2170:TET2
2047:OSMI
1953:base
1919:UDP-
1888:UDP-
1801:The
1792:lung
1707:IRS1
1701:and
1673:MAPT
1669:PFKL
1665:AKT1
1650:and
1598:NCBI
1555:PDBe
1510:KEGG
1353:gene
1021:8473
575:iris
452:Bgee
400:Band
361:Chr.
299:Band
258:Chr.
212:9675
192:OMIM
149:5C1D
145:5BNW
141:4XIF
137:4XI9
133:4N3B
129:4N3A
125:4N39
121:4GZ6
117:4GZ5
113:4GZ3
109:4GYY
105:4GYW
101:4CDR
97:4AY6
93:4AY5
89:3TAX
85:3PE4
81:3PE3
77:1W3B
58:RCSB
55:PDBe
4850:PMC
4842:doi
4801:PMC
4793:doi
3666:PMC
3658:doi
3646:324
3603:doi
3566:PMC
3556:doi
3498:doi
3486:446
3450:PMC
3442:doi
3438:140
3401:PMC
3393:doi
3349:PMC
3341:doi
3297:PMC
3281:doi
3232:PMC
3222:doi
3210:108
3173:PMC
3165:doi
3153:493
3116:PMC
3106:doi
3051:doi
3039:451
3003:doi
2999:110
2962:PMC
2954:doi
2913:PMC
2905:doi
2901:132
2840:PMC
2830:doi
2826:285
2789:PMC
2781:doi
2769:480
2732:PMC
2724:doi
2683:PMC
2673:doi
2632:PMC
2624:doi
2612:469
2560:doi
2556:267
2516:PMC
2508:doi
2467:PMC
2459:doi
2418:PMC
2410:doi
2336:doi
2332:272
2176:to
1819:UDP
1697:in
1677:TAU
1634:or
1574:PMC
1546:PDB
1365:to
1350:OGT
1333:or
1331:OGT
422:End
321:End
224:OMA
220:OGT
200:MGI
179:OGT
48:PDB
24:OGT
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2219:O
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2203:O
2190:O
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2166:O
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2132:O
2128:O
2116:O
2101:O
2094:N
2090:O
2086:O
2041:S
2037:S
2029:S
2025:S
2023:5
2021:4
2013:S
2011:5
2005:O
1989:N
1985:O
1973:N
1969:N
1945:L
1941:D
1937:N
1933:O
1929:L
1925:D
1921:N
1914:L
1910:D
1906:N
1902:O
1898:L
1894:D
1890:N
1878:O
1863:N
1859:N
1855:O
1839:N
1835:C
1831:C
1827:N
1807:O
1731:O
1719:N
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1691:O
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1640:S
1628:O
1622:N
1444:O
1430:d
1426:N
1424:-
1422:O
1418:d
1414:N
1406:N
1402:N
1395:N
1391:O
1382:O
1358:O
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1325:O
346:)
243:)
226::
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