328:
305:
2691:
202:
227:
579:
29:
334:
233:
4868:
4888:
1731:
Schneider, Carolin; Hilbert, Jorina; Genevaux, Franziska; Höfer, Stefanie; Krauß, Lukas; Schicktanz, Felix; Contreras, Constanza Tapia; Jansari, Shaishavi; Papargyriou, Aristeidis; Richter, Thorsten; Alfayomy, Abdallah M.; Falcomatà , Chiara; Schneeweis, Christian; Orben, Felix; Öllinger, Ruppert
55:
2731:
3016:
2690:
1962:"Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase"
2724:
2717:
2493:
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol".
341:
240:
2924:
2249:
Chen ZP, McConell GK, Michell BJ, et al. (2000). "AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation".
3472:
4311:
2775:
2208:"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"
4420:
1995:
Stapleton D, Woollatt E, Mitchelhill KI, et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location".
1542:). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular
3158:
3045:
1218:
2524:"AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling"
149:
3433:
2645:
provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
1199:
4406:
3871:
2762:
2744:
4508:
4389:
2034:"Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components"
4962:
4095:
2165:"Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase"
1655:
4933:
4159:
3134:
2670:
1637:
4952:
4415:
2331:"Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity"
327:
2949:
2594:"Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis"
4472:
4147:
1458:
304:
4587:
3404:
3394:
3079:
2452:"Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells"
1465:
4086:
2559:"Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner"
1717:
1673:
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996).
4355:
4027:
3389:
3380:
1836:
Shaw, Reuben J; Bardeesy Nabeel; Manning
Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004).
1624:
1603:
1562:
have been observed. A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.
1535:
4743:
1620:
1927:"Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro"
226:
201:
52:
3770:
3267:
3258:
2915:
2861:
4858:
2417:"Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase"
1599:
2958:
1539:
129:
1892:"Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase"
1571:
340:
239:
2709:
3982:
3800:
3296:
2699:: Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain)
333:
232:
4728:
4926:
4844:
4831:
4818:
4805:
4792:
4779:
4766:
3972:
3967:
3962:
3952:
3947:
3942:
3932:
3727:
3502:
3098:
2663:
1554:. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.
4738:
4692:
4635:
4195:
4186:
4137:
2903:
2748:
1263:
173:
137:
120:, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
4640:
4495:
3918:
1543:
1244:
1547:
4661:
4580:
3194:
4733:
2112:"Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression"
4919:
3761:
2656:
2123:
1555:
215:
116:
4697:
1441:
1437:
1416:
1412:
1408:
1398:
1394:
1390:
1362:
1358:
4269:
2288:"The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes"
4957:
4630:
4372:
4326:
2623:
2317:
2274:
2063:
2020:
1818:
161:
1386:
1382:
1337:
1333:
3632:
3341:
2615:
2580:
2545:
2510:
2481:
2438:
2403:
2360:
2309:
2266:
2237:
2194:
2151:
2098:
2055:
2012:
1983:
1948:
1913:
1867:
1859:
1810:
1802:
1751:
1696:
109:
45:
4903:
1733:
4676:
4671:
4645:
4573:
4225:
3467:
3457:
3452:
3370:
3361:
3291:
3282:
3228:
3219:
2876:
2605:
2570:
2535:
2502:
2471:
2463:
2428:
2393:
2385:
2350:
2342:
2299:
2258:
2227:
2219:
2184:
2176:
2141:
2131:
2088:
2045:
2004:
1973:
1938:
1903:
1849:
1792:
1759:
1741:
1686:
578:
420:
351:
295:
250:
179:
157:
4723:
4707:
4620:
4051:
3122:
3117:
3112:
1559:
1551:
395:
2127:
2077:"Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase"
1764:
28:
4872:
4761:
4702:
2476:
2451:
2355:
2330:
1908:
1891:
2610:
2593:
2398:
2373:
2304:
2287:
2232:
2207:
2189:
2164:
2050:
2033:
2008:
1797:
1780:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
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903:
898:
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888:
883:
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868:
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848:
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833:
828:
823:
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747:
742:
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683:
678:
673:
668:
663:
658:
653:
648:
643:
640:
635:
630:
625:
620:
4946:
4666:
4625:
3175:
3107:
2642:
2262:
2146:
2111:
607:
2321:
2278:
2067:
2024:
1822:
1734:"A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction"
141:
4899:
4615:
4046:
2871:
2627:
413:
192:
1550:
ratio. AMPK regulates the activities of a number of key metabolic enzymes through
1538:
family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (
165:
4839:
4774:
4610:
4252:
3884:
3824:
3707:
3627:
3351:
2467:
2346:
1660:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1642:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4867:
2389:
496:
4340:
2814:
1854:
1837:
1718:"Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit"
312:
209:
145:
2093:
2076:
1978:
1961:
1943:
1926:
1863:
1806:
1755:
4813:
4787:
3301:
1781:"TSC2 mediates cellular energy response to control cell growth and survival"
1163:
556:
434:
379:
366:
278:
265:
153:
2619:
2584:
2575:
2558:
2549:
2540:
2523:
2514:
2506:
2485:
2442:
2433:
2416:
2407:
2364:
2313:
2270:
2241:
2198:
2155:
2136:
1871:
1814:
1746:
2102:
2059:
2016:
1987:
1952:
1917:
1700:
1691:
1674:
1505:
1500:
3657:
3552:
3547:
3542:
2374:"Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase"
1489:
1308:
1289:
4316:
4294:
4289:
4279:
4274:
4076:
4071:
4066:
4061:
4056:
4041:
4036:
3687:
3652:
2891:
2886:
2881:
1275:
1230:
2223:
86:
82:
78:
74:
4826:
4596:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4467:
4462:
4457:
4452:
4447:
4430:
4425:
4299:
4284:
4235:
4230:
4215:
4210:
4205:
4200:
4174:
4169:
4164:
4152:
4130:
4125:
4017:
3992:
3667:
3492:
3487:
3482:
3477:
3462:
3306:
3243:
3238:
3233:
3209:
3035:
3030:
3004:
2999:
2994:
2984:
2979:
2969:
2809:
2740:
1521:
1473:
1185:
4887:
2180:
4800:
4442:
4435:
4345:
4242:
4142:
4120:
4115:
4110:
4105:
4100:
4012:
4007:
4002:
3997:
3987:
3957:
3937:
3814:
3809:
3790:
3785:
3775:
3751:
3746:
3741:
3717:
3712:
3702:
3697:
3692:
3682:
3662:
3647:
3642:
3637:
3617:
3612:
3602:
3597:
3592:
3587:
3582:
3572:
3567:
3562:
3557:
3537:
3532:
3527:
3522:
3517:
3512:
3497:
3447:
3442:
3336:
3331:
3326:
3321:
3316:
3311:
3272:
3204:
3199:
3148:
3143:
3069:
3064:
3059:
3025:
3017:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2819:
2804:
2799:
2794:
2789:
2784:
1148:
1144:
4895:
4335:
4262:
4257:
4247:
4220:
3977:
3927:
3908:
3903:
3898:
3893:
3848:
3843:
3838:
3833:
3780:
3736:
3677:
3672:
3622:
3607:
3577:
3507:
3423:
3418:
3413:
3346:
3248:
3189:
3184:
3088:
3054:
2939:
2934:
2929:
2898:
2866:
2854:
2849:
2844:
2834:
2829:
1575:
1528:
133:
4569:
4493:
3869:
2760:
2713:
2652:
1838:"The LKB1 tumor suppressor negatively regulates mTOR signaling"
587:
4304:
2839:
2824:
2648:
959:
negative regulation of glucosylceramide biosynthetic process
2329:
Diggle TA, Subkhankulova T, Lilley KS, et al. (2001).
2110:
da Silva Xavier G, Leclerc I, Salt IP, et al. (2000).
2032:
Velasco G, Gómez del Pulgar T, Carling D, Guzmán M (1998).
4565:
2522:
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002).
1570:
Protein kinase, AMP-activated, alpha 1 has been shown to
1518:
5'-AMP-activated protein kinase catalytic subunit alpha-1
1084:
negative regulation of insulin receptor signaling pathway
1064:
positive regulation of protein targeting to mitochondrion
829:
positive regulation of skeletal muscle tissue development
403:
4907:
1034:
regulation of signal transduction by p53 class mediator
969:
positive regulation of cholesterol biosynthetic process
4856:
2163:
Hallows KR, Raghuram V, Kemp BE, et al. (2000).
1890:
Munday MR, Campbell DG, Carling D, Hardie DG (1988).
1779:
Inoki, Ken; Zhu
Tianqing; Guan Kun-Liang (Nov 2003).
568:
2450:
Fryer LG, Foufelle F, Barnes K, et al. (2002).
954:
positive regulation of cell population proliferation
4752:
4716:
4685:
4654:
4603:
4507:
4405:
4388:
4371:
4354:
4325:
4185:
4085:
4026:
3917:
3883:
3823:
3799:
3760:
3726:
3432:
3403:
3379:
3360:
3281:
3257:
3218:
3174:
3157:
3133:
3097:
3078:
3044:
3015:
2948:
2914:
2774:
2286:Blázquez C, Geelen MJ, Velasco G, Guzmán M (2001).
2075:Crute BE, Seefeld K, Gamble J, et al. (1999).
1960:Hawley SA, Davison M, Woods A, et al. (1996).
1430:
1381:
1351:
1326:
1104:
regulation of microtubule cytoskeleton organization
2592:Horman S, Browne G, Krause U, et al. (2003).
1925:Woods A, Cheung PC, Smith FC, et al. (1996).
1675:"Mammalian AMP-activated protein kinase subfamily"
1616:
1614:
1612:
1595:
1593:
1591:
1134:positive regulation of peptidyl-lysine acetylation
1059:positive regulation of mitochondrial transcription
350:
249:
2557:Esumi H, Izuishi K, Kato K, et al. (2002).
1534:The protein encoded by this gene belongs to the
16:Protein-coding gene in the species Homo sapiens
2372:Wang X, Li W, Williams M, et al. (2001).
1621:GRCm38: Ensembl release 89: ENSMUSG00000050697
984:negative regulation of lipid catabolic process
4927:
4581:
2776:Non-specific serine/threonine protein kinases
2725:
2664:
944:regulation of peptidyl-serine phosphorylation
889:cellular response to prostaglandin E stimulus
8:
1129:negative regulation of tubulin deacetylation
784:cellular response to organonitrogen compound
2206:Zhang QH, Ye M, Wu XY, et al. (2001).
1600:GRCh38: Ensembl release 89: ENSG00000132356
1124:positive regulation of protein localization
713:nucleotide-activated protein kinase complex
4934:
4920:
4588:
4574:
4566:
4504:
4490:
3880:
3866:
3159:Goodpasture-antigen-binding protein kinase
2771:
2757:
2732:
2718:
2710:
2671:
2657:
2649:
1378:
1159:
809:regulation of transcription, DNA-templated
603:
391:
290:
187:
63:
3872:Serine/threonine-specific protein kinases
3046:(isocitrate dehydrogenase (NADP+)) kinase
2763:Serine/threonine-specific protein kinases
2745:Serine/threonine-specific protein kinases
2609:
2574:
2539:
2475:
2432:
2397:
2354:
2303:
2231:
2188:
2145:
2135:
2092:
2049:
1977:
1942:
1907:
1853:
1796:
1763:
1745:
1690:
1004:positive regulation of glycolytic process
4407:Receptor protein serine/threonine kinase
1712:
1710:
859:negative regulation of apoptotic process
854:regulation of vesicle-mediated transport
669:protein serine/threonine kinase activity
4863:
4390:Low-density-lipoprotein receptor kinase
2686:
1587:
794:cellular response to glucose starvation
1558:transcript variants encoding distinct
1069:negative regulation of gene expression
1024:cellular response to hydrogen peroxide
914:positive regulation of gene expression
636:cAMP-dependent protein kinase activity
18:
3135:Fas-activated serine/threonine kinase
1114:cellular response to glucose stimulus
1094:regulation of stress granule assembly
1074:cellular response to oxidative stress
644:AMP-activated protein kinase activity
355:
316:
311:
254:
213:
208:
7:
4884:
4882:
4416:Bone morphogenetic protein receptors
949:cellular response to nutrient levels
904:negative regulation of TOR signaling
2950:Dephospho-(reductase kinase) kinase
4906:. You can help Knowledge (XXG) by
3405:G-protein coupled receptor kinases
1909:10.1111/j.1432-1033.1988.tb14201.x
1427:
1348:
1323:
1299:
1280:
1254:
1235:
1209:
1190:
748:intracellular anatomical structure
573:
491:
429:
408:
14:
3395:Beta adrenergic receptor kinase-2
3080:(tyrosine 3-monooxygenase) kinase
2251:Am. J. Physiol. Endocrinol. Metab
1524:that in humans is encoded by the
1079:intracellular signal transduction
4886:
4866:
4087:Mitogen-activated protein kinase
2689:
2263:10.1152/ajpendo.2000.279.5.E1202
1109:cellular response to calcium ion
1039:positive regulation of autophagy
979:cholesterol biosynthetic process
577:
339:
332:
326:
303:
238:
231:
225:
200:
27:
4473:Anti-MĂĽllerian hormone receptor
4356:(acetyl-CoA carboxylase) kinase
4028:(RNA-polymerase)-subunit kinase
3390:Beta adrenergic receptor kinase
3381:Beta adrenergic receptor kinase
1536:serine/threonine protein kinase
924:fatty acid biosynthetic process
4096:Extracellular signal-regulated
2415:Xi X, Han J, Zhang JZ (2001).
934:regulation of circadian rhythm
649:histone serine kinase activity
588:More reference expression data
557:More reference expression data
1:
4963:Human chromosome 5 gene stubs
4160:P38 mitogen-activated protein
3259:cGMP-dependent protein kinase
3220:cAMP-dependent protein kinase
2916:Pyruvate dehydrogenase kinase
2862:Ataxia telangiectasia mutated
2611:10.1016/S0960-9822(02)01077-1
2305:10.1016/S0014-5793(01)02089-0
2051:10.1016/S0014-5793(98)01400-8
2009:10.1016/S0014-5793(97)00569-3
1798:10.1016/S0092-8674(03)00929-2
1009:response to hydrogen peroxide
864:cholesterol metabolic process
834:protein heterooligomerization
515:epithelium of small intestine
324:
223:
2959:AMP-activated protein kinase
2116:Proc. Natl. Acad. Sci. U.S.A
1791:(5). United States: 577–90.
1049:regulation of macroautophagy
1044:CAMKK-AMPK signaling cascade
1029:steroid biosynthetic process
1014:cellular response to hypoxia
884:transcription, DNA-templated
879:fatty acid metabolic process
819:cellular response to ethanol
4953:Genes on human chromosome 5
3874:(EC 2.7.11.21-EC 2.7.11.30)
1099:neuron cellular homeostasis
989:response to gamma radiation
799:sterol biosynthetic process
674:tau-protein kinase activity
465:stromal cell of endometrium
4979:
4881:
3801:Elongation factor 2 kinase
2765:(EC 2.7.11.1-EC 2.7.11.20)
1848:(1). United States: 91–9.
804:lipid biosynthetic process
763:protein-containing complex
679:protein C-terminus binding
4744:Michaelis–Menten kinetics
4503:
4489:
4196:MAP kinase kinase kinases
3879:
3865:
3728:Myosin light-chain kinase
3434:Ca2+/calmodulin-dependent
3099:Myosin-heavy-chain kinase
2770:
2756:
2684:
2468:10.1042/0264-6021:3630167
2347:10.1042/0264-6021:3530621
1855:10.1016/j.ccr.2004.06.007
1656:"Mouse PubMed Reference:"
1638:"Human PubMed Reference:"
1504:
1499:
1495:
1488:
1472:
1453:
1434:
1405:
1374:
1355:
1330:
1319:
1306:
1302:
1287:
1283:
1274:
1261:
1257:
1242:
1238:
1229:
1216:
1212:
1197:
1193:
1184:
1169:
1162:
1158:
1142:
964:glucose metabolic process
789:steroid metabolic process
606:
602:
585:
576:
567:
554:
535:medial vestibular nucleus
503:
494:
481:Descending thoracic aorta
441:
432:
402:
394:
390:
373:
360:
323:
302:
293:
289:
272:
259:
222:
199:
190:
186:
177:
172:
127:
124:
114:
107:
102:
71:
66:
49:
44:
39:
35:
26:
21:
4636:Diffusion-limited enzyme
4496:Dual-specificity kinases
2390:10.1093/emboj/20.16.4370
2094:10.1074/jbc.273.52.35347
1979:10.1074/jbc.271.44.27879
1944:10.1074/jbc.271.48.30517
919:response to camptothecin
3919:Cyclin-dependent kinase
899:protein phosphorylation
631:protein kinase activity
2576:10.1074/jbc.M112270200
2541:10.1074/jbc.C200171200
2507:10.1006/abbi.2002.2778
2495:Arch. Biochem. Biophys
2434:10.1074/jbc.M102824200
2137:10.1073/pnas.97.8.4023
1747:10.1002/advs.202307695
1466:Chr 15: 5.17 – 5.21 Mb
1459:Chr 5: 40.76 – 40.8 Mb
1054:chromatin organization
929:fatty acid homeostasis
718:apical plasma membrane
543:ventral tegmental area
4729:Eadie–Hofstee diagram
4662:Allosteric regulation
1692:10.1074/jbc.271.2.611
1556:Alternatively spliced
869:Wnt signaling pathway
318:Chromosome 15 (mouse)
4739:Lineweaver–Burk plot
3762:Phosphorylase kinase
974:response to caffeine
939:fatty acid oxidation
874:response to activity
621:transferase activity
539:lateral hypothalamus
531:ventromedial nucleus
523:white adipose tissue
216:Chromosome 5 (human)
67:List of PDB id codes
40:Available structures
2128:2000PNAS...97.4023D
1019:signal transduction
824:glucose homeostasis
814:response to hypoxia
697:tau protein binding
511:islet of Langerhans
469:epithelium of colon
4894:This article on a
4698:Enzyme superfamily
4631:Enzyme promiscuity
4373:Tropomyosin kinase
4327:Tau-protein kinase
1264:ENSMUSG00000050697
1119:energy homeostasis
777:Biological process
768:neuronal cell body
706:Cellular component
626:nucleotide binding
614:Molecular function
166:PRKAA1 - orthologs
4915:
4914:
4854:
4853:
4563:
4562:
4559:
4558:
4555:
4554:
4485:
4484:
4481:
4480:
3861:
3860:
3857:
3856:
3342:Protein kinase N1
3297:Protein kinase Cζ
2707:
2706:
2224:10.1101/gr.140200
1515:
1514:
1511:
1510:
1484:
1483:
1449:
1448:
1424:
1423:
1370:
1369:
1345:
1344:
1315:
1314:
1296:
1295:
1270:
1269:
1251:
1250:
1225:
1224:
1206:
1205:
1154:
1153:
659:metal ion binding
654:chromatin binding
598:
597:
594:
593:
563:
562:
550:
549:
488:
487:
386:
385:
285:
284:
98:
97:
94:
93:
50:Ortholog search:
4970:
4936:
4929:
4922:
4890:
4883:
4871:
4870:
4862:
4734:Hanes–Woolf plot
4677:Enzyme activator
4672:Enzyme inhibitor
4646:Enzyme catalysis
4590:
4583:
4576:
4567:
4505:
4491:
4138:C-Jun N-terminal
3881:
3867:
3371:Rhodopsin kinase
3362:Rhodopsin kinase
3292:Protein kinase C
3283:Protein kinase C
3268:Protein kinase G
3229:Protein kinase A
2840:Protein kinase B
2772:
2758:
2734:
2727:
2720:
2711:
2693:
2673:
2666:
2659:
2650:
2631:
2613:
2588:
2578:
2553:
2543:
2534:(27): 23977–80.
2518:
2489:
2479:
2462:(Pt 1): 167–74.
2446:
2436:
2427:(44): 41029–34.
2411:
2401:
2368:
2358:
2325:
2307:
2282:
2245:
2235:
2202:
2192:
2159:
2149:
2139:
2106:
2096:
2087:(52): 35347–54.
2071:
2053:
2028:
1991:
1981:
1972:(44): 27879–87.
1956:
1946:
1937:(17): 10282–90.
1921:
1911:
1876:
1875:
1857:
1833:
1827:
1826:
1800:
1776:
1770:
1769:
1767:
1749:
1738:Advanced Science
1728:
1722:
1721:
1714:
1705:
1704:
1694:
1670:
1664:
1663:
1652:
1646:
1645:
1634:
1628:
1618:
1607:
1597:
1497:
1496:
1468:
1461:
1444:
1428:
1419:
1379:
1375:RefSeq (protein)
1365:
1349:
1340:
1324:
1300:
1281:
1255:
1236:
1210:
1191:
1160:
909:cold acclimation
849:lipid metabolism
839:rhythmic process
604:
590:
581:
574:
559:
499:
497:Top expressed in
492:
477:body of pancreas
437:
435:Top expressed in
430:
409:
392:
382:
369:
358:
343:
336:
330:
319:
307:
291:
281:
268:
257:
242:
235:
229:
218:
204:
188:
182:
168:
119:
112:
89:
64:
58:
37:
36:
31:
19:
4978:
4977:
4973:
4972:
4971:
4969:
4968:
4967:
4943:
4942:
4941:
4940:
4879:
4877:
4865:
4857:
4855:
4850:
4762:Oxidoreductases
4748:
4724:Enzyme kinetics
4712:
4708:List of enzymes
4681:
4650:
4621:Catalytic triad
4599:
4594:
4564:
4551:
4499:
4477:
4401:
4384:
4367:
4350:
4321:
4181:
4081:
4052:P70-S6 Kinase 1
4022:
3913:
3875:
3853:
3819:
3795:
3756:
3722:
3428:
3399:
3375:
3356:
3277:
3253:
3214:
3170:
3153:
3129:
3123:Aurora C kinase
3118:Aurora B kinase
3113:Aurora A kinase
3093:
3074:
3040:
3011:
2944:
2910:
2766:
2752:
2738:
2708:
2703:
2700:
2694:
2680:
2677:
2639:
2634:
2604:(16): 1419–23.
2591:
2569:(36): 32791–8.
2556:
2521:
2492:
2449:
2414:
2371:
2341:(Pt 3): 621–6.
2328:
2298:(2–3): 149–53.
2285:
2248:
2218:(10): 1546–60.
2205:
2181:10.1172/JCI9622
2175:(12): 1711–21.
2169:J. Clin. Invest
2162:
2109:
2074:
2031:
1994:
1959:
1924:
1896:Eur. J. Biochem
1889:
1885:
1883:Further reading
1880:
1879:
1835:
1834:
1830:
1778:
1777:
1773:
1730:
1729:
1725:
1716:
1715:
1708:
1672:
1671:
1667:
1654:
1653:
1649:
1636:
1635:
1631:
1619:
1610:
1598:
1589:
1584:
1568:
1552:phosphorylation
1506:View/Edit Mouse
1501:View/Edit Human
1464:
1457:
1454:Location (UCSC)
1440:
1436:
1415:
1411:
1407:
1401:
1397:
1393:
1389:
1385:
1361:
1357:
1336:
1332:
1245:ENSG00000132356
1138:
844:phosphorylation
772:
701:
684:protein binding
664:kinase activity
586:
555:
546:
541:
537:
533:
529:
525:
521:
519:mammillary body
517:
513:
509:
495:
484:
479:
475:
473:tibial arteries
471:
467:
463:
459:
455:
451:
447:
445:Achilles tendon
433:
377:
364:
356:
346:
345:
344:
337:
317:
294:Gene location (
276:
263:
255:
245:
244:
243:
236:
214:
191:Gene location (
178:
128:
115:
108:
73:
51:
17:
12:
11:
5:
4976:
4974:
4966:
4965:
4960:
4955:
4945:
4944:
4939:
4938:
4931:
4924:
4916:
4913:
4912:
4891:
4876:
4875:
4852:
4851:
4849:
4848:
4835:
4822:
4809:
4796:
4783:
4770:
4756:
4754:
4750:
4749:
4747:
4746:
4741:
4736:
4731:
4726:
4720:
4718:
4714:
4713:
4711:
4710:
4705:
4700:
4695:
4689:
4687:
4686:Classification
4683:
4682:
4680:
4679:
4674:
4669:
4664:
4658:
4656:
4652:
4651:
4649:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4607:
4605:
4601:
4600:
4595:
4593:
4592:
4585:
4578:
4570:
4561:
4560:
4557:
4556:
4553:
4552:
4550:
4549:
4544:
4539:
4534:
4529:
4524:
4519:
4513:
4511:
4501:
4500:
4494:
4487:
4486:
4483:
4482:
4479:
4478:
4476:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4439:
4438:
4433:
4428:
4423:
4412:
4410:
4409:(EC 2.7.11.30)
4403:
4402:
4400:
4399:
4395:
4393:
4392:(EC 2.7.11.29)
4386:
4385:
4383:
4382:
4378:
4376:
4375:(EC 2.7.11.28)
4369:
4368:
4366:
4365:
4361:
4359:
4358:(EC 2.7.11.27)
4352:
4351:
4349:
4348:
4343:
4338:
4332:
4330:
4329:(EC 2.7.11.26)
4323:
4322:
4320:
4319:
4314:
4309:
4308:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4267:
4266:
4265:
4260:
4255:
4250:
4240:
4239:
4238:
4233:
4228:
4223:
4218:
4213:
4208:
4203:
4192:
4190:
4189:(EC 2.7.11.25)
4183:
4182:
4180:
4179:
4178:
4177:
4172:
4167:
4157:
4156:
4155:
4150:
4145:
4135:
4134:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4092:
4090:
4089:(EC 2.7.11.24)
4083:
4082:
4080:
4079:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4039:
4033:
4031:
4030:(EC 2.7.11.23)
4024:
4023:
4021:
4020:
4015:
4010:
4005:
4000:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3935:
3930:
3924:
3922:
3921:(EC 2.7.11.22)
3915:
3914:
3912:
3911:
3906:
3901:
3896:
3890:
3888:
3887:(EC 2.7.11.21)
3877:
3876:
3870:
3863:
3862:
3859:
3858:
3855:
3854:
3852:
3851:
3846:
3841:
3836:
3830:
3828:
3827:(EC 2.7.11.21)
3821:
3820:
3818:
3817:
3812:
3806:
3804:
3803:(EC 2.7.11.20)
3797:
3796:
3794:
3793:
3788:
3783:
3778:
3773:
3767:
3765:
3764:(EC 2.7.11.19)
3758:
3757:
3755:
3754:
3749:
3744:
3739:
3733:
3731:
3730:(EC 2.7.11.18)
3724:
3723:
3721:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3439:
3437:
3436:(EC 2.7.11.17)
3430:
3429:
3427:
3426:
3421:
3416:
3410:
3408:
3407:(EC 2.7.11.16)
3401:
3400:
3398:
3397:
3392:
3386:
3384:
3383:(EC 2.7.11.15)
3377:
3376:
3374:
3373:
3367:
3365:
3364:(EC 2.7.11.14)
3358:
3357:
3355:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3288:
3286:
3285:(EC 2.7.11.13)
3279:
3278:
3276:
3275:
3270:
3264:
3262:
3261:(EC 2.7.11.12)
3255:
3254:
3252:
3251:
3246:
3241:
3236:
3231:
3225:
3223:
3222:(EC 2.7.11.11)
3216:
3215:
3213:
3212:
3207:
3202:
3197:
3192:
3187:
3181:
3179:
3178:(EC 2.7.11.10)
3172:
3171:
3169:
3168:
3164:
3162:
3155:
3154:
3152:
3151:
3146:
3140:
3138:
3131:
3130:
3128:
3127:
3126:
3125:
3120:
3115:
3104:
3102:
3095:
3094:
3092:
3091:
3085:
3083:
3076:
3075:
3073:
3072:
3067:
3062:
3057:
3051:
3049:
3042:
3041:
3039:
3038:
3033:
3028:
3022:
3020:
3013:
3012:
3010:
3009:
3008:
3007:
3002:
2997:
2989:
2988:
2987:
2982:
2974:
2973:
2972:
2967:
2955:
2953:
2946:
2945:
2943:
2942:
2937:
2932:
2927:
2921:
2919:
2912:
2911:
2909:
2908:
2907:
2906:
2896:
2895:
2894:
2889:
2884:
2879:
2869:
2864:
2859:
2858:
2857:
2852:
2847:
2837:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2797:
2792:
2787:
2781:
2779:
2768:
2767:
2761:
2754:
2753:
2739:
2737:
2736:
2729:
2722:
2714:
2705:
2704:
2702:
2701:
2695:
2688:
2685:
2682:
2681:
2678:
2676:
2675:
2668:
2661:
2653:
2647:
2646:
2638:
2637:External links
2635:
2633:
2632:
2589:
2554:
2519:
2490:
2447:
2412:
2384:(16): 4370–9.
2369:
2326:
2283:
2257:(5): E1202–6.
2246:
2203:
2160:
2107:
2072:
2029:
1992:
1957:
1922:
1886:
1884:
1881:
1878:
1877:
1828:
1771:
1732:(2024-06-17).
1723:
1706:
1665:
1647:
1629:
1608:
1586:
1585:
1583:
1580:
1567:
1564:
1513:
1512:
1509:
1508:
1503:
1493:
1492:
1486:
1485:
1482:
1481:
1479:
1477:
1470:
1469:
1462:
1455:
1451:
1450:
1447:
1446:
1432:
1431:
1425:
1422:
1421:
1403:
1402:
1376:
1372:
1371:
1368:
1367:
1353:
1352:
1346:
1343:
1342:
1328:
1327:
1321:
1317:
1316:
1313:
1312:
1304:
1303:
1297:
1294:
1293:
1285:
1284:
1278:
1272:
1271:
1268:
1267:
1259:
1258:
1252:
1249:
1248:
1240:
1239:
1233:
1227:
1226:
1223:
1222:
1214:
1213:
1207:
1204:
1203:
1195:
1194:
1188:
1182:
1181:
1176:
1171:
1167:
1166:
1156:
1155:
1152:
1151:
1140:
1139:
1137:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1089:motor behavior
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
999:response to UV
996:
994:macroautophagy
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
780:
778:
774:
773:
771:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
709:
707:
703:
702:
700:
699:
694:
689:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
638:
633:
628:
623:
617:
615:
611:
610:
600:
599:
596:
595:
592:
591:
583:
582:
571:
565:
564:
561:
560:
552:
551:
548:
547:
545:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
501:
500:
489:
486:
485:
483:
482:
478:
474:
470:
466:
462:
461:gastric mucosa
458:
454:
450:
446:
442:
439:
438:
426:
425:
417:
406:
400:
399:
396:RNA expression
388:
387:
384:
383:
375:
371:
370:
362:
359:
354:
348:
347:
338:
331:
325:
321:
320:
315:
309:
308:
300:
299:
287:
286:
283:
282:
274:
270:
269:
261:
258:
253:
247:
246:
237:
230:
224:
220:
219:
212:
206:
205:
197:
196:
184:
183:
176:
170:
169:
126:
122:
121:
113:
105:
104:
100:
99:
96:
95:
92:
91:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4975:
4964:
4961:
4959:
4956:
4954:
4951:
4950:
4948:
4937:
4932:
4930:
4925:
4923:
4918:
4917:
4911:
4909:
4905:
4901:
4897:
4892:
4889:
4885:
4880:
4874:
4869:
4864:
4860:
4846:
4842:
4841:
4836:
4833:
4829:
4828:
4823:
4820:
4816:
4815:
4810:
4807:
4803:
4802:
4797:
4794:
4790:
4789:
4784:
4781:
4777:
4776:
4771:
4768:
4764:
4763:
4758:
4757:
4755:
4751:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4721:
4719:
4715:
4709:
4706:
4704:
4703:Enzyme family
4701:
4699:
4696:
4694:
4691:
4690:
4688:
4684:
4678:
4675:
4673:
4670:
4668:
4667:Cooperativity
4665:
4663:
4660:
4659:
4657:
4653:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4626:Oxyanion hole
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4608:
4606:
4602:
4598:
4591:
4586:
4584:
4579:
4577:
4572:
4571:
4568:
4548:
4545:
4543:
4540:
4538:
4535:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4514:
4512:
4510:
4506:
4502:
4497:
4492:
4488:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4418:
4417:
4414:
4413:
4411:
4408:
4404:
4397:
4396:
4394:
4391:
4387:
4380:
4379:
4377:
4374:
4370:
4363:
4362:
4360:
4357:
4353:
4347:
4344:
4342:
4339:
4337:
4334:
4333:
4331:
4328:
4324:
4318:
4315:
4313:
4310:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4272:
4271:
4268:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4245:
4244:
4241:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4198:
4197:
4194:
4193:
4191:
4188:
4184:
4176:
4173:
4171:
4168:
4166:
4163:
4162:
4161:
4158:
4154:
4151:
4149:
4146:
4144:
4141:
4140:
4139:
4136:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4098:
4097:
4094:
4093:
4091:
4088:
4084:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4034:
4032:
4029:
4025:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3925:
3923:
3920:
3916:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3891:
3889:
3886:
3882:
3878:
3873:
3868:
3864:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3831:
3829:
3826:
3822:
3816:
3813:
3811:
3808:
3807:
3805:
3802:
3798:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3768:
3766:
3763:
3759:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3734:
3732:
3729:
3725:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3440:
3438:
3435:
3431:
3425:
3422:
3420:
3417:
3415:
3412:
3411:
3409:
3406:
3402:
3396:
3393:
3391:
3388:
3387:
3385:
3382:
3378:
3372:
3369:
3368:
3366:
3363:
3359:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3289:
3287:
3284:
3280:
3274:
3271:
3269:
3266:
3265:
3263:
3260:
3256:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3226:
3224:
3221:
3217:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3182:
3180:
3177:
3173:
3166:
3165:
3163:
3161:(EC 2.7.11.9)
3160:
3156:
3150:
3147:
3145:
3142:
3141:
3139:
3137:(EC 2.7.11.8)
3136:
3132:
3124:
3121:
3119:
3116:
3114:
3111:
3110:
3109:
3108:Aurora kinase
3106:
3105:
3103:
3101:(EC 2.7.11.7)
3100:
3096:
3090:
3087:
3086:
3084:
3082:(EC 2.7.11.6)
3081:
3077:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3052:
3050:
3048:(EC 2.7.11.5)
3047:
3043:
3037:
3034:
3032:
3029:
3027:
3024:
3023:
3021:
3019:(EC 2.7.11.4)
3018:
3014:
3006:
3003:
3001:
2998:
2996:
2993:
2992:
2990:
2986:
2983:
2981:
2978:
2977:
2975:
2971:
2968:
2966:
2963:
2962:
2960:
2957:
2956:
2954:
2952:(EC 2.7.11.3)
2951:
2947:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2922:
2920:
2918:(EC 2.7.11.2)
2917:
2913:
2905:
2902:
2901:
2900:
2897:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2874:
2873:
2872:EIF-2 kinases
2870:
2868:
2865:
2863:
2860:
2856:
2853:
2851:
2848:
2846:
2843:
2842:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2782:
2780:
2778:(EC 2.7.11.1)
2777:
2773:
2769:
2764:
2759:
2755:
2750:
2746:
2742:
2735:
2730:
2728:
2723:
2721:
2716:
2715:
2712:
2698:
2692:
2687:
2683:
2674:
2669:
2667:
2662:
2660:
2655:
2654:
2651:
2644:
2641:
2640:
2636:
2629:
2625:
2621:
2617:
2612:
2607:
2603:
2599:
2595:
2590:
2586:
2582:
2577:
2572:
2568:
2564:
2563:J. Biol. Chem
2560:
2555:
2551:
2547:
2542:
2537:
2533:
2529:
2528:J. Biol. Chem
2525:
2520:
2516:
2512:
2508:
2504:
2501:(1): 105–10.
2500:
2496:
2491:
2487:
2483:
2478:
2473:
2469:
2465:
2461:
2457:
2453:
2448:
2444:
2440:
2435:
2430:
2426:
2422:
2421:J. Biol. Chem
2418:
2413:
2409:
2405:
2400:
2395:
2391:
2387:
2383:
2379:
2375:
2370:
2366:
2362:
2357:
2352:
2348:
2344:
2340:
2336:
2332:
2327:
2323:
2319:
2315:
2311:
2306:
2301:
2297:
2293:
2289:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2247:
2243:
2239:
2234:
2229:
2225:
2221:
2217:
2213:
2209:
2204:
2200:
2196:
2191:
2186:
2182:
2178:
2174:
2170:
2166:
2161:
2157:
2153:
2148:
2143:
2138:
2133:
2129:
2125:
2122:(8): 4023–8.
2121:
2117:
2113:
2108:
2104:
2100:
2095:
2090:
2086:
2082:
2081:J. Biol. Chem
2078:
2073:
2069:
2065:
2061:
2057:
2052:
2047:
2044:(3): 317–20.
2043:
2039:
2035:
2030:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1993:
1989:
1985:
1980:
1975:
1971:
1967:
1966:J. Biol. Chem
1963:
1958:
1954:
1950:
1945:
1940:
1936:
1932:
1931:J. Biol. Chem
1928:
1923:
1919:
1915:
1910:
1905:
1901:
1897:
1893:
1888:
1887:
1882:
1873:
1869:
1865:
1861:
1856:
1851:
1847:
1843:
1839:
1832:
1829:
1824:
1820:
1816:
1812:
1808:
1804:
1799:
1794:
1790:
1786:
1782:
1775:
1772:
1766:
1761:
1757:
1753:
1748:
1743:
1739:
1735:
1727:
1724:
1719:
1713:
1711:
1707:
1702:
1698:
1693:
1688:
1684:
1680:
1676:
1669:
1666:
1661:
1657:
1651:
1648:
1643:
1639:
1633:
1630:
1626:
1622:
1617:
1615:
1613:
1609:
1605:
1601:
1596:
1594:
1592:
1588:
1581:
1579:
1577:
1573:
1565:
1563:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1532:
1530:
1527:
1523:
1519:
1507:
1502:
1498:
1494:
1491:
1487:
1480:
1478:
1475:
1471:
1467:
1463:
1460:
1456:
1452:
1445:
1443:
1439:
1433:
1429:
1426:
1420:
1418:
1414:
1410:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1377:
1373:
1366:
1364:
1360:
1354:
1350:
1347:
1341:
1339:
1335:
1329:
1325:
1322:
1320:RefSeq (mRNA)
1318:
1311:
1310:
1305:
1301:
1298:
1292:
1291:
1286:
1282:
1279:
1277:
1273:
1266:
1265:
1260:
1256:
1253:
1247:
1246:
1241:
1237:
1234:
1232:
1228:
1221:
1220:
1215:
1211:
1208:
1202:
1201:
1196:
1192:
1189:
1187:
1183:
1180:
1177:
1175:
1172:
1168:
1165:
1161:
1157:
1150:
1146:
1141:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
781:
779:
776:
775:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
743:nuclear speck
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
710:
708:
705:
704:
698:
695:
693:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
618:
616:
613:
612:
609:
608:Gene ontology
605:
601:
589:
584:
580:
575:
572:
570:
566:
558:
553:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
505:
502:
498:
493:
490:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
443:
440:
436:
431:
428:
427:
424:
422:
418:
416:
415:
411:
410:
407:
405:
401:
397:
393:
389:
381:
376:
372:
368:
363:
357:15|15 A1
353:
349:
342:
335:
329:
322:
314:
310:
306:
301:
297:
292:
288:
280:
275:
271:
267:
262:
252:
248:
241:
234:
228:
221:
217:
211:
207:
203:
198:
194:
189:
185:
181:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
123:
118:
111:
106:
101:
90:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
4908:expanding it
4900:chromosome 5
4893:
4878:
4840:Translocases
4837:
4824:
4811:
4798:
4785:
4775:Transferases
4772:
4759:
4616:Binding site
4047:P70S6 kinase
2964:
2696:
2601:
2597:
2566:
2562:
2531:
2527:
2498:
2494:
2459:
2455:
2424:
2420:
2381:
2377:
2338:
2334:
2295:
2291:
2254:
2250:
2215:
2211:
2172:
2168:
2119:
2115:
2084:
2080:
2041:
2037:
2003:(3): 452–6.
2000:
1996:
1969:
1965:
1934:
1930:
1902:(2): 331–8.
1899:
1895:
1845:
1841:
1831:
1788:
1784:
1774:
1737:
1726:
1685:(2): 611–4.
1682:
1678:
1668:
1659:
1650:
1641:
1632:
1569:
1566:Interactions
1533:
1525:
1517:
1516:
1442:NP_001342569
1438:NP_001013385
1435:
1417:NP_001341966
1413:NP_001341965
1409:NP_001341964
1406:
1399:NP_001341963
1395:NP_001341958
1391:NP_001341957
1363:NM_001355640
1359:NM_001013367
1356:
1331:
1307:
1288:
1262:
1243:
1217:
1198:
1178:
1173:
419:
412:
125:External IDs
72:
4611:Active site
4498:(EC 2.7.12)
3885:Polo kinase
3825:Polo kinase
2679:PDB gallery
1842:Cancer Cell
1679:J Biol Chem
723:nucleoplasm
692:ATP binding
507:granulocyte
457:gallbladder
277:40,798,374
264:40,759,379
103:Identifiers
4947:Categories
4814:Isomerases
4788:Hydrolases
4655:Regulation
3176:IÎşB kinase
2751:2.7.11-12)
2598:Curr. Biol
2456:Biochem. J
2335:Biochem. J
2212:Genome Res
1627:, May 2017
1606:, May 2017
1582:References
423:(ortholog)
378:5,211,380
365:5,173,343
146:HomoloGene
4958:EC 2.7.11
4898:on human
4693:EC number
3302:PKC alpha
2292:FEBS Lett
2038:FEBS Lett
1997:FEBS Lett
1864:1535-6108
1807:0092-8674
1756:2198-3844
1387:NP_996790
1383:NP_006242
1338:NM_206907
1334:NM_006251
1164:Orthologs
894:autophagy
733:cytoplasm
180:2.7.11.26
174:EC number
154:GeneCards
4717:Kinetics
4641:Cofactor
4604:Activity
3658:KIAA0999
3553:MAPKAPK5
3548:MAPKAPK3
3543:MAPKAPK2
2620:12194824
2585:12091379
2550:11997383
2515:11913976
2486:11903059
2443:11546797
2408:11500364
2365:11171059
2322:35584617
2314:11165240
2279:13387968
2271:11052978
2242:11042152
2199:10862786
2156:10760274
2068:29493620
2025:39329574
1872:15261145
1823:18173817
1815:14651849
1765:11336956
1623:–
1602:–
1572:interact
1560:isoforms
1490:Wikidata
1143:Sources:
758:dendrite
4873:Biology
4827:Ligases
4597:Enzymes
4317:MAP3K14
4295:MAP3K11
4290:MAP3K10
4280:MAP3K13
4275:MAP3K12
4077:RPS6KC1
4072:RPS6KA1
4067:RPS6KA3
4062:RPS6KA2
4057:RPS6KB2
4042:RPS6KA4
4037:RPS6KA5
3688:Kalirin
3653:SNF1LK2
2892:EIF2AK4
2887:EIF2AK3
2741:Kinases
2643:PDBe-KB
2628:9865400
2477:1222463
2356:1221608
2124:Bibcode
2103:9857077
2060:9845345
2017:9224708
1988:8910387
1953:8626596
1918:2900138
1701:8557660
1625:Ensembl
1604:Ensembl
1276:UniProt
1231:Ensembl
1170:Species
1149:QuickGO
738:cytosol
728:nucleus
398:pattern
142:2145955
110:Aliases
4859:Portal
4801:Lyases
4547:MAP2K7
4542:MAP2K6
4537:MAP2K5
4532:MAP2K4
4527:MAP2K3
4522:MAP2K2
4517:MAP2K1
4468:ACVRL1
4463:ACVR2B
4458:ACVR2A
4453:ACVR1C
4448:ACVR1B
4431:BMPR1B
4426:BMPR1A
4300:MAP3K7
4285:MAP3K9
4236:MAP3K8
4231:MAP3K7
4226:MAP3K6
4221:MAP3K5
4216:MAP3K4
4211:MAP3K3
4206:MAP3K2
4201:MAP3K1
4175:MAPK14
4170:MAPK13
4165:MAPK11
4153:MAPK10
4131:MAPK15
4126:MAPK12
4018:CDC2L1
3993:CDC2L5
3668:SNF1LK
3493:CAMK2G
3488:CAMK2D
3483:CAMK2B
3478:CAMK2A
3468:CAMK1G
3463:CAMK1D
3458:CAMK1B
3453:CAMK1A
3307:PRKCB1
3244:PRKACA
3239:PRKACB
3234:PRKACG
3210:IKBKAP
3036:BCKDHB
3031:BCKDHA
3005:PRKAG3
3000:PRKAG2
2995:PRKAG1
2985:PRKAB2
2980:PRKAB1
2970:PRKAA2
2965:PRKAA1
2810:STK38L
2626:
2618:
2583:
2548:
2513:
2484:
2474:
2441:
2406:
2399:125559
2396:
2378:EMBO J
2363:
2353:
2320:
2312:
2277:
2269:
2240:
2233:310934
2230:
2197:
2190:378514
2187:
2154:
2144:
2101:
2066:
2058:
2023:
2015:
1986:
1951:
1916:
1870:
1862:
1821:
1813:
1805:
1762:
1754:
1699:
1526:PRKAA1
1522:enzyme
1520:is an
1476:search
1474:PubMed
1309:Q5EG47
1290:Q13131
1219:105787
1186:Entrez
569:BioGPS
453:rectum
158:PRKAA1
134:602739
117:PRKAA1
22:PRKAA1
4902:is a
4753:Types
4509:MAP2K
4443:ACVR1
4436:BMPR2
4421:BMPR1
4346:GSK-3
4187:MAP3K
4148:MAPK9
4143:MAPK8
4121:MAPK7
4116:MAPK6
4111:MAPK4
4106:MAPK3
4101:MAPK1
4013:PFTK1
4008:PCTK3
4003:PCTK2
3998:PCTK1
3988:CDK12
3983:CDK10
3958:CDKL5
3938:CDKL2
3815:STK19
3810:EEF2K
3791:PHKG2
3786:PHKG1
3776:PHKA2
3771:PHKA1
3752:MYLK4
3747:MYLK3
3742:MYLK2
3718:DCLK1
3713:Titin
3703:TRIB3
3698:TRIB2
3693:TRIB1
3683:TSSK2
3663:STK40
3648:PSKH1
3643:PRKD3
3638:PRKD2
3618:PHKG2
3613:PHKG1
3603:OBSCN
3598:NUAK2
3593:NUAK1
3588:MKNK2
3583:MKNK1
3573:MARK4
3568:MARK3
3563:MARK2
3558:MARK1
3538:STK11
3533:DAPK3
3528:DAPK2
3523:DAPK1
3518:CHEK2
3513:CHEK1
3498:CAMK4
3473:CAMK2
3448:CAMK1
3443:BRSK2
3337:PRKCQ
3332:PRKCI
3327:PRKCG
3322:PRKCH
3317:PRKCE
3312:PRKCD
3273:PRKG1
3205:IKBKG
3200:IKBKE
3149:STK10
3144:FASTK
3070:IDH3G
3065:IDH3B
3060:IDH3A
3026:BCKDK
2820:ROCK1
2805:STK38
2800:MAST2
2795:MAST1
2790:LATS2
2785:LATS1
2624:S2CID
2318:S2CID
2275:S2CID
2147:18135
2064:S2CID
2021:S2CID
1819:S2CID
1574:with
1179:Mouse
1174:Human
1145:Amigo
449:sperm
421:Mouse
414:Human
361:Start
296:Mouse
260:Start
193:Human
150:49590
4904:stub
4896:gene
4845:list
4838:EC7
4832:list
4825:EC6
4819:list
4812:EC5
4806:list
4799:EC4
4793:list
4786:EC3
4780:list
4773:EC2
4767:list
4760:EC1
4336:TPK1
4312:CDC7
4270:MLKs
4263:KSR2
4258:KSR1
4253:BRAF
4248:ARAF
4243:RAFs
3978:CDK9
3973:CDK8
3968:CDK7
3963:CDK6
3953:CDK5
3948:CDK4
3943:CDK3
3933:CDK2
3928:CDK1
3909:PLK4
3904:PLK3
3899:PLK2
3894:PLK1
3849:PLK4
3844:PLK3
3839:PLK2
3834:PLK1
3781:PHKB
3737:MYLK
3708:TRIO
3678:SPEG
3673:SNRK
3633:PKD1
3628:PIM2
3623:PIM1
3608:PASK
3578:MELK
3508:CASK
3503:MLCK
3424:GRK6
3419:GRK5
3414:GRK4
3352:PKN3
3347:PKN2
3249:PRKY
3195:TBK1
3190:IKK2
3185:CHUK
3089:STK4
3055:IDH2
2940:PDK4
2935:PDK3
2930:PDK2
2925:PDK1
2904:WEE1
2899:Wee1
2867:mTOR
2855:AKT3
2850:AKT2
2845:AKT1
2835:SGK3
2830:SGK2
2697:2h6d
2616:PMID
2581:PMID
2546:PMID
2511:PMID
2482:PMID
2439:PMID
2404:PMID
2361:PMID
2310:PMID
2267:PMID
2238:PMID
2195:PMID
2152:PMID
2099:PMID
2056:PMID
2013:PMID
1984:PMID
1949:PMID
1914:PMID
1868:PMID
1860:ISSN
1811:PMID
1803:ISSN
1785:Cell
1752:ISSN
1697:PMID
1576:TSC2
1540:AMPK
1529:gene
1200:5562
753:axon
527:hand
404:Bgee
352:Band
313:Chr.
251:Band
210:Chr.
130:OMIM
87:5EZV
83:4REW
79:4RER
75:4RED
56:RCSB
53:PDBe
4341:TTK
4305:ZAK
2882:HRI
2877:PKR
2825:SGK
2815:CIT
2606:doi
2571:doi
2567:277
2536:doi
2532:277
2503:doi
2499:400
2472:PMC
2464:doi
2460:363
2429:doi
2425:276
2394:PMC
2386:doi
2351:PMC
2343:doi
2339:353
2300:doi
2296:489
2259:doi
2255:279
2228:PMC
2220:doi
2185:PMC
2177:doi
2173:105
2142:PMC
2132:doi
2089:doi
2085:273
2046:doi
2042:439
2005:doi
2001:409
1974:doi
1970:271
1939:doi
1935:271
1904:doi
1900:175
1850:doi
1793:doi
1789:115
1760:PMC
1742:doi
1687:doi
1683:271
1548:ATP
1544:AMP
374:End
273:End
256:n/a
162:OMA
138:MGI
46:PDB
4949::
2991:Îł
2976:β
2961:α
2749:EC
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