242:
219:
116:
141:
493:
248:
147:
4573:
4593:
1274:(PKD) family function in many extracellular receptor-mediated signal transduction pathways. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.
2053:
Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways".
2436:
2721:
2023:
Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells".
1601:
Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (August 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C".
1456:
Owczarek CM, Portbury KJ, Kola I, Hertzog PJ (September 2000). "Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids".
2429:
1994:
Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46".
1918:"Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes"
2381:"Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis"
2422:
2629:
255:
154:
1717:
Van Lint J, Rykx A, Maeda Y, Vantus T, Sturany S, Malhotra V, Vandenheede JR, Seufferlein T (2002). "Protein kinase D: an intracellular traffic regulator on the move".
3177:
4016:
2480:
4125:
2863:
2750:
961:
77:
3138:
942:
1636:
Rao PS, Jaggi M, Smith DJ, Hemstreet GP, Balaji KC (October 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer".
4111:
3576:
2467:
2449:
4667:
4213:
4094:
2303:"Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages"
4638:
3800:
2669:
1812:"Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654"
4657:
3864:
2839:
1397:
1379:
4120:
241:
2654:
4177:
3852:
1189:
1196:
218:
4292:
3109:
3099:
2784:
1865:"Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654"
772:
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
3791:
1502:
4060:
3732:
3094:
3085:
1366:
1345:
140:
115:
4448:
1362:
3475:
2972:
2963:
2620:
2566:
4563:
1341:
2663:
57:
2190:"Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor"
2085:"The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C"
1283:
1961:"Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling"
1291:
254:
153:
2414:
4631:
3687:
3505:
3001:
4433:
247:
146:
4549:
4536:
4523:
4510:
4497:
4484:
4471:
3677:
3672:
3667:
3657:
3652:
3647:
3637:
3432:
3207:
2803:
4443:
4397:
4340:
3900:
3891:
3842:
2608:
2453:
1006:
65:
4345:
4200:
3623:
987:
2155:"Gbetagamma-mediated regulation of Golgi organization is through the direct activation of protein kinase D"
4624:
4366:
4285:
2899:
129:
4438:
1271:
3466:
1876:
1823:
1516:
Johannes FJ, Hausser A, Storz P, Truckenmüller L, Link G, Kawakami T, Pfizenmaier K (November 1999).
44:
4402:
2153:
Jamora C, Yamanouye N, Van Lint J, Laudenslager J, Vandenheede JR, Faulkner DJ, Malhotra V (1999).
1172:
1168:
1164:
1139:
1131:
1084:
1080:
3974:
4662:
4335:
4077:
4031:
1481:
1309:
1303:
89:
1671:
Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, Johannes FJ (April 1999).
1160:
1135:
1105:
1076:
3046:
2402:
2367:
2324:
2289:
2254:
2219:
2176:
2141:
2106:
2071:
2041:
2011:
1982:
1947:
1904:
1851:
1798:
1755:
1734:
1694:
1653:
1618:
1583:
1560:
Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes FJ (August 2000).
1539:
1473:
1438:
37:
4608:
4381:
4376:
4350:
4278:
3930:
3172:
3162:
3157:
3075:
3066:
2996:
2987:
2933:
2924:
2581:
2392:
2357:
2349:
2314:
2279:
2244:
2231:
Johannes FJ, Hausser A, Storz P, Truckenmüller L, Link G, Kawakami T, Pfizenmaier K (1999).
2209:
2201:
2166:
2131:
2096:
2063:
2033:
2003:
1972:
1937:
1929:
1894:
1884:
1841:
1831:
1788:
1780:
1726:
1684:
1645:
1610:
1573:
1529:
1465:
1428:
334:
265:
209:
164:
2268:"Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32"
1562:"Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32"
492:
85:
4428:
4412:
4325:
3756:
2827:
2822:
2817:
2118:
Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, Johannes FJ (1999).
309:
1769:"Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C"
2379:
Vertommen D, Rider M, Ni Y, Waelkens E, Merlevede W, Vandenheede JR, Van Lint J (2000).
1880:
1827:
4577:
4466:
4407:
2266:
Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes FJ (2000).
2214:
2189:
1784:
2362:
2337:
2249:
2232:
2171:
2154:
1977:
1960:
1942:
1917:
1899:
1864:
1846:
1811:
1793:
1768:
1730:
1614:
1534:
1517:
1433:
1416:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
630:
625:
620:
615:
610:
605:
600:
595:
579:
574:
569:
564:
559:
554:
549:
544:
539:
534:
4651:
4604:
4371:
4330:
2880:
2812:
521:
2120:"Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins"
1959:
Sidorenko SP, Law CL, Klaus SJ, Chandran KA, Takata M, Kurosaki T, Clark EA (1996).
1933:
1673:"Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins"
1485:
4320:
3751:
2576:
327:
106:
69:
2319:
2302:
93:
4544:
4479:
4315:
3957:
3589:
3529:
3412:
3332:
3056:
1402:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1384:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4572:
2353:
2205:
1649:
410:
4045:
2519:
226:
123:
73:
4518:
4492:
3006:
2136:
2119:
2101:
2084:
2067:
1889:
1689:
1672:
906:
470:
348:
293:
280:
192:
179:
81:
2406:
2397:
2380:
2371:
2328:
2293:
2284:
2267:
2258:
2223:
2180:
2145:
2110:
2037:
2007:
1836:
1738:
1698:
1657:
1622:
1587:
1578:
1561:
1543:
1477:
1415:
Johannes FJ, Prestle J, Eis S, Oberhagemann P, Pfizenmaier K (April 1994).
2075:
2045:
2015:
1986:
1951:
1908:
1855:
1802:
1442:
1236:
1231:
3362:
3257:
3252:
3247:
1220:
1051:
1032:
4021:
3999:
3994:
3984:
3979:
3781:
3776:
3771:
3766:
3761:
3746:
3741:
3392:
3357:
2596:
2591:
2586:
1759:
1018:
973:
1469:
4531:
4301:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4172:
4167:
4162:
4157:
4152:
4135:
4130:
4004:
3989:
3940:
3935:
3920:
3915:
3910:
3905:
3879:
3874:
3869:
3857:
3835:
3830:
3722:
3697:
3372:
3197:
3192:
3187:
3182:
3167:
3011:
2948:
2943:
2938:
2914:
2740:
2735:
2709:
2704:
2699:
2689:
2684:
2674:
2514:
2445:
1252:
1204:
928:
4592:
2233:"Bruton's tyrosine kinase (Btk) associates with protein kinase C mu"
1518:"Bruton's tyrosine kinase (Btk) associates with protein kinase C mu"
4505:
4147:
4140:
4050:
3947:
3847:
3825:
3820:
3815:
3810:
3805:
3717:
3712:
3707:
3702:
3692:
3662:
3642:
3519:
3514:
3495:
3490:
3480:
3456:
3451:
3446:
3422:
3417:
3407:
3402:
3397:
3387:
3367:
3352:
3347:
3342:
3322:
3317:
3307:
3302:
3297:
3292:
3287:
3277:
3272:
3267:
3262:
3242:
3237:
3232:
3227:
3222:
3217:
3202:
3152:
3147:
3041:
3036:
3031:
3026:
3021:
3016:
2977:
2909:
2904:
2853:
2848:
2774:
2769:
2764:
2730:
2722:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2524:
2509:
2504:
2499:
2494:
2489:
1315:
1297:
1417:"PKCu is a novel, atypical member of the protein kinase C family"
891:
887:
4600:
4040:
3967:
3962:
3952:
3925:
3682:
3632:
3613:
3608:
3603:
3598:
3553:
3548:
3543:
3538:
3485:
3441:
3382:
3377:
3327:
3312:
3282:
3212:
3128:
3123:
3118:
3051:
2953:
2894:
2889:
2793:
2759:
2644:
2639:
2634:
2603:
2571:
2559:
2554:
2549:
2539:
2534:
1259:
797:
cellular response to vascular endothelial growth factor stimulus
61:
4274:
4198:
3574:
2465:
2418:
501:
4009:
2544:
2529:
762:
positive regulation of blood vessel endothelial cell migration
752:
positive regulation of NF-kappaB transcription factor activity
847:
positive regulation of phosphatidylinositol 3-kinase activity
742:
vascular endothelial growth factor receptor signaling pathway
2338:"Spatial and temporal regulation of protein kinase D (PKD)"
2188:
Bagowski CP, Stein-Gerlach M, Choidas A, Ullrich A (1999).
4270:
777:
positive regulation of I-kappaB kinase/NF-kappaB signaling
2336:
Matthews SA, Iglesias T, Rozengurt E, Cantrell D (2000).
827:
positive regulation of transcription by RNA polymerase II
737:
positive regulation of CREB transcription factor activity
317:
4612:
712:
positive regulation of peptidyl-serine phosphorylation
4561:
662:
positive regulation of endothelial cell proliferation
482:
767:
positive regulation of neuron projection development
48:, PKC-MU, PKCM, PKD, PRKCM, Protein kinase D1, CHDED
4457:
4421:
4390:
4359:
4308:
4212:
4110:
4093:
4076:
4059:
4030:
3890:
3790:
3731:
3622:
3588:
3528:
3504:
3465:
3431:
3137:
3108:
3084:
3065:
2986:
2962:
2923:
2879:
2862:
2838:
2802:
2783:
2749:
2720:
2653:
2619:
2479:
1153:
1124:
1098:
1069:
732:
positive regulation of histone deacetylase activity
1358:
1356:
1354:
1337:
1335:
1333:
687:positive regulation of endothelial cell chemotaxis
862:positive regulation of osteoblast differentiation
747:regulation of integrin-mediated signaling pathway
722:positive regulation of endothelial cell migration
264:
163:
16:Protein-coding gene in the species Homo sapiens
2301:Mayne M, Holden CP, Nath A, Geiger JD (2000).
1555:
1553:
1363:GRCm38: Ensembl release 89: ENSMUSG00000002688
4632:
4286:
2481:Non-specific serine/threonine protein kinases
2430:
8:
2083:Waldron RT, Iglesias T, Rozengurt E (1999).
1767:Jakobovits A, Rosenthal A, Capon DJ (1990).
1342:GRCh38: Ensembl release 89: ENSG00000184304
4639:
4625:
4293:
4279:
4271:
4209:
4195:
3585:
3571:
2864:Goodpasture-antigen-binding protein kinase
2476:
2462:
2437:
2423:
2415:
902:
842:cellular response to amino acid starvation
517:
305:
204:
101:
3577:Serine/threonine-specific protein kinases
2751:(isocitrate dehydrogenase (NADP+)) kinase
2468:Serine/threonine-specific protein kinases
2450:Serine/threonine-specific protein kinases
2396:
2361:
2318:
2283:
2248:
2213:
2170:
2135:
2100:
1976:
1941:
1916:Conant K, Ma M, Nath A, Major EO (1996).
1898:
1888:
1845:
1835:
1792:
1688:
1577:
1533:
1432:
4112:Receptor protein serine/threonine kinase
1746:Busch H, Eisenhart-Rothe BV (1976). "".
1497:
1495:
857:regulation of keratinocyte proliferation
580:protein serine/threonine kinase activity
4568:
4095:Low-density-lipoprotein receptor kinase
1329:
1503:"Entrez Gene: PRKD1 protein kinase D1"
18:
2840:Fas-activated serine/threonine kinase
792:cellular response to oxidative stress
611:integral component of plasma membrane
269:
230:
225:
168:
127:
122:
7:
4589:
4587:
4121:Bone morphogenetic protein receptors
1748:Münchener medizinische Wochenschrift
1282:Protein kinase D1 has been shown to
2655:Dephospho-(reductase kinase) kinase
782:integrin-mediated signaling pathway
717:positive regulation of angiogenesis
4611:. You can help Knowledge (XXG) by
3110:G-protein coupled receptor kinases
1785:10.1002/j.1460-2075.1990.tb08223.x
1249:Serine/threonine-protein kinase D1
1150:
1121:
1095:
1066:
1042:
1023:
997:
978:
952:
933:
877:peptidyl-threonine phosphorylation
852:cellular response to hydroperoxide
647:negative regulation of endocytosis
487:
405:
343:
322:
14:
3100:Beta adrenergic receptor kinase-2
2785:(tyrosine 3-monooxygenase) kinase
1255:that in humans is encoded by the
702:negative regulation of cell death
697:sphingolipid biosynthetic process
657:intracellular signal transduction
4591:
4571:
3792:Mitogen-activated protein kinase
837:positive regulation of autophagy
491:
253:
246:
240:
217:
152:
145:
139:
114:
4178:Anti-Müllerian hormone receptor
4061:(acetyl-CoA carboxylase) kinase
3733:(RNA-polymerase)-subunit kinase
3095:Beta adrenergic receptor kinase
3086:Beta adrenergic receptor kinase
1934:10.1128/JVI.70.3.1384-1389.1996
872:peptidyl-serine phosphorylation
802:Ras protein signal transduction
667:regulation of protein stability
4668:Human chromosome 14 gene stubs
3801:Extracellular signal-regulated
502:More reference expression data
471:More reference expression data
1:
3865:P38 mitogen-activated protein
2964:cGMP-dependent protein kinase
2925:cAMP-dependent protein kinase
2621:Pyruvate dehydrogenase kinase
2567:Ataxia telangiectasia mutated
2250:10.1016/S0014-5793(99)01424-6
2172:10.1016/S0092-8674(00)80606-6
2026:Biochem. Biophys. Res. Commun
1978:10.1016/S1074-7613(00)80261-7
1731:10.1016/S0962-8924(02)02262-6
1638:Biochem. Biophys. Res. Commun
1615:10.1016/s0006-291x(03)01187-2
1603:Biochem. Biophys. Res. Commun
1535:10.1016/s0014-5793(99)01424-6
1434:10.1016/S0021-9258(17)37580-4
807:cell population proliferation
238:
137:
4658:Genes on human chromosome 14
2664:AMP-activated protein kinase
2320:10.4049/jimmunol.164.12.6538
1869:Proc. Natl. Acad. Sci. U.S.A
1816:Proc. Natl. Acad. Sci. U.S.A
3579:(EC 2.7.11.21-EC 2.7.11.30)
2056:AIDS Res. Hum. Retroviruses
1863:Davis RJ, Czech MP (1985).
1810:Davis RJ, Czech MP (1985).
787:protein autophosphorylation
4684:
4586:
3506:Elongation factor 2 kinase
2470:(EC 2.7.11.1-EC 2.7.11.20)
1650:10.1016/j.bbrc.2003.09.118
707:nervous system development
692:protein kinase D signaling
4449:Michaelis–Menten kinetics
4208:
4194:
3901:MAP kinase kinase kinases
3584:
3570:
3433:Myosin light-chain kinase
3139:Ca2+/calmodulin-dependent
2804:Myosin-heavy-chain kinase
2475:
2461:
1398:"Mouse PubMed Reference:"
1380:"Human PubMed Reference:"
1235:
1230:
1226:
1219:
1203:
1184:
1157:
1128:
1117:
1102:
1073:
1062:
1049:
1045:
1030:
1026:
1017:
1004:
1000:
985:
981:
972:
959:
955:
940:
936:
927:
912:
905:
901:
885:
570:identical protein binding
550:protein kinase C activity
520:
516:
499:
490:
481:
468:
417:
408:
383:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
4341:Diffusion-limited enzyme
4201:Dual-specificity kinases
2354:10.1093/emboj/19.12.2935
2206:10.1093/emboj/18.20.5567
1292:Bruton's tyrosine kinase
1197:Chr 12: 50.34 – 50.65 Mb
1190:Chr 14: 29.58 – 30.19 Mb
3624:Cyclin-dependent kinase
2137:10.1074/jbc.274.14.9258
2102:10.1074/jbc.274.14.9224
2068:10.1089/aid.1998.14.825
1890:10.1073/pnas.82.12.4080
1690:10.1074/jbc.274.14.9258
867:Golgi vesicle transport
727:protein phosphorylation
545:protein kinase activity
433:internal carotid artery
429:external carotid artery
2398:10.1074/jbc.M001357200
2285:10.1074/jbc.M002964200
2038:10.1006/bbrc.1997.7877
2008:10.1006/abbi.1996.0476
1996:Arch. Biochem. Biophys
1837:10.1073/pnas.82.7.1974
1579:10.1074/jbc.M002964200
817:innate immune response
616:autophagosome membrane
4434:Eadie–Hofstee diagram
4367:Allosteric regulation
812:inflammatory response
682:immune system process
387:right coronary artery
232:Chromosome 12 (mouse)
130:Chromosome 14 (human)
4444:Lineweaver–Burk plot
3467:Phosphorylase kinase
1458:Cytogenet Cell Genet
652:cell differentiation
535:transferase activity
1881:1985PNAS...82.4080D
1828:1985PNAS...82.1974D
822:signal transduction
626:trans-Golgi network
4599:This article on a
4403:Enzyme superfamily
4336:Enzyme promiscuity
4078:Tropomyosin kinase
4032:Tau-protein kinase
1310:Metallothionein 2A
1304:Centaurin, alpha 1
1007:ENSMUSG00000002688
672:Golgi organization
640:Biological process
589:Cellular component
540:nucleotide binding
528:Molecular function
453:epithelium of lens
4620:
4619:
4559:
4558:
4268:
4267:
4264:
4263:
4260:
4259:
4190:
4189:
4186:
4185:
3566:
3565:
3562:
3561:
3047:Protein kinase N1
3002:Protein kinase Cζ
1470:10.1159/000015624
1246:
1245:
1242:
1241:
1215:
1214:
1180:
1179:
1147:
1146:
1113:
1112:
1092:
1091:
1058:
1057:
1039:
1038:
1013:
1012:
994:
993:
968:
967:
949:
948:
897:
896:
832:apoptotic process
555:metal ion binding
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:PRKD1 - orthologs
4675:
4641:
4634:
4627:
4595:
4588:
4576:
4575:
4567:
4439:Hanes–Woolf plot
4382:Enzyme activator
4377:Enzyme inhibitor
4351:Enzyme catalysis
4295:
4288:
4281:
4272:
4210:
4196:
3843:C-Jun N-terminal
3586:
3572:
3076:Rhodopsin kinase
3067:Rhodopsin kinase
2997:Protein kinase C
2988:Protein kinase C
2973:Protein kinase G
2934:Protein kinase A
2545:Protein kinase B
2477:
2463:
2439:
2432:
2425:
2416:
2410:
2400:
2391:(26): 19567–76.
2375:
2365:
2332:
2322:
2297:
2287:
2262:
2252:
2227:
2217:
2184:
2174:
2149:
2139:
2114:
2104:
2079:
2049:
2019:
1990:
1980:
1955:
1945:
1912:
1902:
1892:
1859:
1849:
1839:
1806:
1796:
1763:
1742:
1719:Trends Cell Biol
1703:
1702:
1692:
1668:
1662:
1661:
1633:
1627:
1626:
1598:
1592:
1591:
1581:
1557:
1548:
1547:
1537:
1513:
1507:
1506:
1499:
1490:
1489:
1453:
1447:
1446:
1436:
1412:
1406:
1405:
1394:
1388:
1387:
1376:
1370:
1360:
1349:
1339:
1272:protein kinase D
1228:
1227:
1199:
1192:
1175:
1151:
1142:
1122:
1118:RefSeq (protein)
1108:
1096:
1087:
1067:
1043:
1024:
998:
979:
953:
934:
903:
518:
504:
495:
488:
473:
425:substantia nigra
421:primitive streak
413:
411:Top expressed in
406:
391:popliteal artery
363:seminal vesicula
359:ventricular zone
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
4683:
4682:
4678:
4677:
4676:
4674:
4673:
4672:
4648:
4647:
4646:
4645:
4584:
4582:
4570:
4562:
4560:
4555:
4467:Oxidoreductases
4453:
4429:Enzyme kinetics
4417:
4413:List of enzymes
4386:
4355:
4326:Catalytic triad
4304:
4299:
4269:
4256:
4204:
4182:
4106:
4089:
4072:
4055:
4026:
3886:
3786:
3757:P70-S6 Kinase 1
3727:
3618:
3580:
3558:
3524:
3500:
3461:
3427:
3133:
3104:
3080:
3061:
2982:
2958:
2919:
2875:
2858:
2834:
2828:Aurora C kinase
2823:Aurora B kinase
2818:Aurora A kinase
2798:
2779:
2745:
2716:
2649:
2615:
2471:
2457:
2443:
2413:
2378:
2348:(12): 2935–45.
2335:
2313:(12): 6538–42.
2300:
2278:(32): 24601–7.
2265:
2230:
2200:(20): 5567–76.
2187:
2152:
2130:(14): 9258–64.
2117:
2095:(14): 9224–30.
2082:
2052:
2022:
1993:
1958:
1915:
1862:
1809:
1766:
1745:
1716:
1712:
1710:Further reading
1707:
1706:
1683:(14): 9258–64.
1670:
1669:
1665:
1635:
1634:
1630:
1600:
1599:
1595:
1572:(32): 24601–7.
1559:
1558:
1551:
1515:
1514:
1510:
1501:
1500:
1493:
1455:
1454:
1450:
1414:
1413:
1409:
1396:
1395:
1391:
1378:
1377:
1373:
1361:
1352:
1340:
1331:
1326:
1321:
1280:
1270:Members of the
1268:
1237:View/Edit Mouse
1232:View/Edit Human
1195:
1188:
1185:Location (UCSC)
1171:
1167:
1163:
1159:
1138:
1134:
1130:
1104:
1083:
1079:
1075:
988:ENSG00000184304
881:
677:phosphorylation
635:
606:plasma membrane
596:Golgi apparatus
584:
565:protein binding
560:kinase activity
500:
469:
460:
455:
451:
449:renal corpuscle
447:
443:
439:
435:
431:
427:
423:
409:
398:
395:tibial arteries
393:
389:
385:
381:
377:
373:
371:ascending aorta
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
4681:
4679:
4671:
4670:
4665:
4660:
4650:
4649:
4644:
4643:
4636:
4629:
4621:
4618:
4617:
4596:
4581:
4580:
4557:
4556:
4554:
4553:
4540:
4527:
4514:
4501:
4488:
4475:
4461:
4459:
4455:
4454:
4452:
4451:
4446:
4441:
4436:
4431:
4425:
4423:
4419:
4418:
4416:
4415:
4410:
4405:
4400:
4394:
4392:
4391:Classification
4388:
4387:
4385:
4384:
4379:
4374:
4369:
4363:
4361:
4357:
4356:
4354:
4353:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4312:
4310:
4306:
4305:
4300:
4298:
4297:
4290:
4283:
4275:
4266:
4265:
4262:
4261:
4258:
4257:
4255:
4254:
4249:
4244:
4239:
4234:
4229:
4224:
4218:
4216:
4206:
4205:
4199:
4192:
4191:
4188:
4187:
4184:
4183:
4181:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4144:
4143:
4138:
4133:
4128:
4117:
4115:
4114:(EC 2.7.11.30)
4108:
4107:
4105:
4104:
4100:
4098:
4097:(EC 2.7.11.29)
4091:
4090:
4088:
4087:
4083:
4081:
4080:(EC 2.7.11.28)
4074:
4073:
4071:
4070:
4066:
4064:
4063:(EC 2.7.11.27)
4057:
4056:
4054:
4053:
4048:
4043:
4037:
4035:
4034:(EC 2.7.11.26)
4028:
4027:
4025:
4024:
4019:
4014:
4013:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3972:
3971:
3970:
3965:
3960:
3955:
3945:
3944:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3897:
3895:
3894:(EC 2.7.11.25)
3888:
3887:
3885:
3884:
3883:
3882:
3877:
3872:
3862:
3861:
3860:
3855:
3850:
3840:
3839:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3797:
3795:
3794:(EC 2.7.11.24)
3788:
3787:
3785:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3738:
3736:
3735:(EC 2.7.11.23)
3729:
3728:
3726:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3629:
3627:
3626:(EC 2.7.11.22)
3620:
3619:
3617:
3616:
3611:
3606:
3601:
3595:
3593:
3592:(EC 2.7.11.21)
3582:
3581:
3575:
3568:
3567:
3564:
3563:
3560:
3559:
3557:
3556:
3551:
3546:
3541:
3535:
3533:
3532:(EC 2.7.11.21)
3526:
3525:
3523:
3522:
3517:
3511:
3509:
3508:(EC 2.7.11.20)
3502:
3501:
3499:
3498:
3493:
3488:
3483:
3478:
3472:
3470:
3469:(EC 2.7.11.19)
3463:
3462:
3460:
3459:
3454:
3449:
3444:
3438:
3436:
3435:(EC 2.7.11.18)
3429:
3428:
3426:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3144:
3142:
3141:(EC 2.7.11.17)
3135:
3134:
3132:
3131:
3126:
3121:
3115:
3113:
3112:(EC 2.7.11.16)
3106:
3105:
3103:
3102:
3097:
3091:
3089:
3088:(EC 2.7.11.15)
3082:
3081:
3079:
3078:
3072:
3070:
3069:(EC 2.7.11.14)
3063:
3062:
3060:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2993:
2991:
2990:(EC 2.7.11.13)
2984:
2983:
2981:
2980:
2975:
2969:
2967:
2966:(EC 2.7.11.12)
2960:
2959:
2957:
2956:
2951:
2946:
2941:
2936:
2930:
2928:
2927:(EC 2.7.11.11)
2921:
2920:
2918:
2917:
2912:
2907:
2902:
2897:
2892:
2886:
2884:
2883:(EC 2.7.11.10)
2877:
2876:
2874:
2873:
2869:
2867:
2860:
2859:
2857:
2856:
2851:
2845:
2843:
2836:
2835:
2833:
2832:
2831:
2830:
2825:
2820:
2809:
2807:
2800:
2799:
2797:
2796:
2790:
2788:
2781:
2780:
2778:
2777:
2772:
2767:
2762:
2756:
2754:
2747:
2746:
2744:
2743:
2738:
2733:
2727:
2725:
2718:
2717:
2715:
2714:
2713:
2712:
2707:
2702:
2694:
2693:
2692:
2687:
2679:
2678:
2677:
2672:
2660:
2658:
2651:
2650:
2648:
2647:
2642:
2637:
2632:
2626:
2624:
2617:
2616:
2614:
2613:
2612:
2611:
2601:
2600:
2599:
2594:
2589:
2584:
2574:
2569:
2564:
2563:
2562:
2557:
2552:
2542:
2537:
2532:
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2486:
2484:
2473:
2472:
2466:
2459:
2458:
2444:
2442:
2441:
2434:
2427:
2419:
2412:
2411:
2376:
2333:
2298:
2263:
2243:(1–2): 68–72.
2228:
2185:
2150:
2115:
2080:
2062:(10): 825–33.
2050:
2020:
1991:
1956:
1913:
1875:(12): 4080–4.
1860:
1807:
1779:(4): 1165–70.
1764:
1743:
1725:(4): 193–200.
1713:
1711:
1708:
1705:
1704:
1663:
1628:
1593:
1549:
1528:(1–2): 68–72.
1508:
1491:
1464:(3–4): 240–1.
1448:
1407:
1389:
1371:
1350:
1328:
1327:
1325:
1322:
1320:
1319:
1313:
1307:
1301:
1295:
1288:
1279:
1276:
1267:
1264:
1244:
1243:
1240:
1239:
1234:
1224:
1223:
1217:
1216:
1213:
1212:
1210:
1208:
1201:
1200:
1193:
1186:
1182:
1181:
1178:
1177:
1155:
1154:
1148:
1145:
1144:
1126:
1125:
1119:
1115:
1114:
1111:
1110:
1100:
1099:
1093:
1090:
1089:
1071:
1070:
1064:
1060:
1059:
1056:
1055:
1047:
1046:
1040:
1037:
1036:
1028:
1027:
1021:
1015:
1014:
1011:
1010:
1002:
1001:
995:
992:
991:
983:
982:
976:
970:
969:
966:
965:
957:
956:
950:
947:
946:
938:
937:
931:
925:
924:
919:
914:
910:
909:
899:
898:
895:
894:
883:
882:
880:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
643:
641:
637:
636:
634:
633:
628:
623:
618:
613:
608:
603:
598:
592:
590:
586:
585:
583:
582:
577:
572:
567:
562:
557:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
441:primary oocyte
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
379:saphenous vein
376:
372:
368:
367:thoracic aorta
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4680:
4669:
4666:
4664:
4661:
4659:
4656:
4655:
4653:
4642:
4637:
4635:
4630:
4628:
4623:
4622:
4616:
4614:
4610:
4606:
4605:chromosome 14
4602:
4597:
4594:
4590:
4585:
4579:
4574:
4569:
4565:
4551:
4547:
4546:
4541:
4538:
4534:
4533:
4528:
4525:
4521:
4520:
4515:
4512:
4508:
4507:
4502:
4499:
4495:
4494:
4489:
4486:
4482:
4481:
4476:
4473:
4469:
4468:
4463:
4462:
4460:
4456:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4426:
4424:
4420:
4414:
4411:
4409:
4408:Enzyme family
4406:
4404:
4401:
4399:
4396:
4395:
4393:
4389:
4383:
4380:
4378:
4375:
4373:
4372:Cooperativity
4370:
4368:
4365:
4364:
4362:
4358:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4331:Oxyanion hole
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4313:
4311:
4307:
4303:
4296:
4291:
4289:
4284:
4282:
4277:
4276:
4273:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4228:
4225:
4223:
4220:
4219:
4217:
4215:
4211:
4207:
4202:
4197:
4193:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4123:
4122:
4119:
4118:
4116:
4113:
4109:
4102:
4101:
4099:
4096:
4092:
4085:
4084:
4082:
4079:
4075:
4068:
4067:
4065:
4062:
4058:
4052:
4049:
4047:
4044:
4042:
4039:
4038:
4036:
4033:
4029:
4023:
4020:
4018:
4015:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3977:
3976:
3973:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3950:
3949:
3946:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3903:
3902:
3899:
3898:
3896:
3893:
3889:
3881:
3878:
3876:
3873:
3871:
3868:
3867:
3866:
3863:
3859:
3856:
3854:
3851:
3849:
3846:
3845:
3844:
3841:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3803:
3802:
3799:
3798:
3796:
3793:
3789:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3739:
3737:
3734:
3730:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3630:
3628:
3625:
3621:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3596:
3594:
3591:
3587:
3583:
3578:
3573:
3569:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3536:
3534:
3531:
3527:
3521:
3518:
3516:
3513:
3512:
3510:
3507:
3503:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3473:
3471:
3468:
3464:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3439:
3437:
3434:
3430:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3145:
3143:
3140:
3136:
3130:
3127:
3125:
3122:
3120:
3117:
3116:
3114:
3111:
3107:
3101:
3098:
3096:
3093:
3092:
3090:
3087:
3083:
3077:
3074:
3073:
3071:
3068:
3064:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2994:
2992:
2989:
2985:
2979:
2976:
2974:
2971:
2970:
2968:
2965:
2961:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2931:
2929:
2926:
2922:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2891:
2888:
2887:
2885:
2882:
2878:
2871:
2870:
2868:
2866:(EC 2.7.11.9)
2865:
2861:
2855:
2852:
2850:
2847:
2846:
2844:
2842:(EC 2.7.11.8)
2841:
2837:
2829:
2826:
2824:
2821:
2819:
2816:
2815:
2814:
2813:Aurora kinase
2811:
2810:
2808:
2806:(EC 2.7.11.7)
2805:
2801:
2795:
2792:
2791:
2789:
2787:(EC 2.7.11.6)
2786:
2782:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2757:
2755:
2753:(EC 2.7.11.5)
2752:
2748:
2742:
2739:
2737:
2734:
2732:
2729:
2728:
2726:
2724:(EC 2.7.11.4)
2723:
2719:
2711:
2708:
2706:
2703:
2701:
2698:
2697:
2695:
2691:
2688:
2686:
2683:
2682:
2680:
2676:
2673:
2671:
2668:
2667:
2665:
2662:
2661:
2659:
2657:(EC 2.7.11.3)
2656:
2652:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2627:
2625:
2623:(EC 2.7.11.2)
2622:
2618:
2610:
2607:
2606:
2605:
2602:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2579:
2578:
2577:EIF-2 kinases
2575:
2573:
2570:
2568:
2565:
2561:
2558:
2556:
2553:
2551:
2548:
2547:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2487:
2485:
2483:(EC 2.7.11.1)
2482:
2478:
2474:
2469:
2464:
2460:
2455:
2451:
2447:
2440:
2435:
2433:
2428:
2426:
2421:
2420:
2417:
2408:
2404:
2399:
2394:
2390:
2386:
2385:J. Biol. Chem
2382:
2377:
2373:
2369:
2364:
2359:
2355:
2351:
2347:
2343:
2339:
2334:
2330:
2326:
2321:
2316:
2312:
2308:
2304:
2299:
2295:
2291:
2286:
2281:
2277:
2273:
2272:J. Biol. Chem
2269:
2264:
2260:
2256:
2251:
2246:
2242:
2238:
2234:
2229:
2225:
2221:
2216:
2211:
2207:
2203:
2199:
2195:
2191:
2186:
2182:
2178:
2173:
2168:
2164:
2160:
2156:
2151:
2147:
2143:
2138:
2133:
2129:
2125:
2124:J. Biol. Chem
2121:
2116:
2112:
2108:
2103:
2098:
2094:
2090:
2089:J. Biol. Chem
2086:
2081:
2077:
2073:
2069:
2065:
2061:
2057:
2051:
2047:
2043:
2039:
2035:
2031:
2027:
2021:
2017:
2013:
2009:
2005:
2001:
1997:
1992:
1988:
1984:
1979:
1974:
1971:(4): 353–63.
1970:
1966:
1962:
1957:
1953:
1949:
1944:
1939:
1935:
1931:
1928:(3): 1384–9.
1927:
1923:
1919:
1914:
1910:
1906:
1901:
1896:
1891:
1886:
1882:
1878:
1874:
1870:
1866:
1861:
1857:
1853:
1848:
1843:
1838:
1833:
1829:
1825:
1822:(7): 1974–8.
1821:
1817:
1813:
1808:
1804:
1800:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1765:
1761:
1757:
1754:(22): 713–8.
1753:
1749:
1744:
1740:
1736:
1732:
1728:
1724:
1720:
1715:
1714:
1709:
1700:
1696:
1691:
1686:
1682:
1678:
1677:J. Biol. Chem
1674:
1667:
1664:
1659:
1655:
1651:
1647:
1644:(3): 1032–8.
1643:
1639:
1632:
1629:
1624:
1620:
1616:
1612:
1609:(3): 459–65.
1608:
1604:
1597:
1594:
1589:
1585:
1580:
1575:
1571:
1567:
1566:J. Biol. Chem
1563:
1556:
1554:
1550:
1545:
1541:
1536:
1531:
1527:
1523:
1519:
1512:
1509:
1504:
1498:
1496:
1492:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1452:
1449:
1444:
1440:
1435:
1430:
1427:(8): 6140–8.
1426:
1422:
1418:
1411:
1408:
1403:
1399:
1393:
1390:
1385:
1381:
1375:
1372:
1368:
1364:
1359:
1357:
1355:
1351:
1347:
1343:
1338:
1336:
1334:
1330:
1323:
1317:
1314:
1311:
1308:
1305:
1302:
1299:
1296:
1293:
1290:
1289:
1287:
1285:
1277:
1275:
1273:
1265:
1263:
1261:
1258:
1254:
1250:
1238:
1233:
1229:
1225:
1222:
1218:
1211:
1209:
1206:
1202:
1198:
1194:
1191:
1187:
1183:
1176:
1174:
1170:
1166:
1162:
1156:
1152:
1149:
1143:
1141:
1137:
1133:
1127:
1123:
1120:
1116:
1109:
1107:
1101:
1097:
1094:
1088:
1086:
1082:
1078:
1072:
1068:
1065:
1063:RefSeq (mRNA)
1061:
1054:
1053:
1048:
1044:
1041:
1035:
1034:
1029:
1025:
1022:
1020:
1016:
1009:
1008:
1003:
999:
996:
990:
989:
984:
980:
977:
975:
971:
964:
963:
958:
954:
951:
945:
944:
939:
935:
932:
930:
926:
923:
920:
918:
915:
911:
908:
904:
900:
893:
889:
884:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
644:
642:
639:
638:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
593:
591:
588:
587:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
556:
553:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:12|12 B3
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4613:expanding it
4598:
4583:
4545:Translocases
4542:
4529:
4516:
4503:
4490:
4480:Transferases
4477:
4464:
4321:Binding site
3752:P70S6 kinase
3337:
2388:
2384:
2345:
2341:
2310:
2306:
2275:
2271:
2240:
2236:
2197:
2193:
2165:(1): 59–68.
2162:
2158:
2127:
2123:
2092:
2088:
2059:
2055:
2032:(2): 332–7.
2029:
2025:
1999:
1995:
1968:
1964:
1925:
1921:
1872:
1868:
1819:
1815:
1776:
1772:
1751:
1747:
1722:
1718:
1680:
1676:
1666:
1641:
1637:
1631:
1606:
1602:
1596:
1569:
1565:
1525:
1521:
1511:
1461:
1457:
1451:
1424:
1420:
1410:
1401:
1392:
1383:
1374:
1281:
1278:Interactions
1269:
1256:
1248:
1247:
1173:NP_001369745
1169:NP_001369744
1165:NP_001369743
1158:
1140:NP_001335319
1132:NP_001316998
1129:
1103:
1085:NM_001348390
1081:NM_001330069
1074:
1050:
1031:
1005:
986:
960:
941:
921:
916:
757:angiogenesis
457:vas deferens
333:
326:
53:External IDs
4316:Active site
4203:(EC 2.7.12)
3590:Polo kinase
3530:Polo kinase
2002:(1): 8–12.
1421:J Biol Chem
575:ATP binding
292:50,649,098
279:50,341,231
191:30,191,898
178:29,576,479
31:Identifiers
4652:Categories
4519:Isomerases
4493:Hydrolases
4360:Regulation
2881:IκB kinase
2456:2.7.11-12)
2307:J. Immunol
1369:, May 2017
1348:, May 2017
1324:References
337:(ortholog)
74:HomoloGene
4663:EC 2.7.11
4603:on human
4398:EC number
3007:PKC alpha
2237:FEBS Lett
1522:FEBS Lett
1161:NP_032884
1136:NP_002733
1106:NM_008858
1077:NM_002742
907:Orthologs
621:cytoplasm
82:GeneCards
4422:Kinetics
4346:Cofactor
4309:Activity
3363:KIAA0999
3258:MAPKAPK5
3253:MAPKAPK3
3248:MAPKAPK2
2407:10867018
2372:10856238
2329:10843712
2294:10831594
2259:10561498
2224:10523301
2181:10412981
2146:10092600
2111:10092595
1965:Immunity
1922:J. Virol
1739:11978539
1699:10092600
1658:14550308
1623:12893243
1588:10831594
1544:10561498
1486:26620985
1478:10965134
1365:–
1344:–
1284:interact
1266:Function
1221:Wikidata
886:Sources:
601:membrane
375:testicle
4578:Biology
4532:Ligases
4302:Enzymes
4022:MAP3K14
4000:MAP3K11
3995:MAP3K10
3985:MAP3K13
3980:MAP3K12
3782:RPS6KC1
3777:RPS6KA1
3772:RPS6KA3
3767:RPS6KA2
3762:RPS6KB2
3747:RPS6KA4
3742:RPS6KA5
3393:Kalirin
3358:SNF1LK2
2597:EIF2AK4
2592:EIF2AK3
2446:Kinases
2215:1171625
2076:9671211
2046:9446795
2016:8914829
1987:8885868
1952:8627654
1909:2987962
1877:Bibcode
1856:2984676
1824:Bibcode
1803:2182321
1443:8119958
1367:Ensembl
1346:Ensembl
1019:UniProt
974:Ensembl
913:Species
892:QuickGO
631:cytosol
445:condyle
312:pattern
38:Aliases
4564:Portal
4506:Lyases
4252:MAP2K7
4247:MAP2K6
4242:MAP2K5
4237:MAP2K4
4232:MAP2K3
4227:MAP2K2
4222:MAP2K1
4173:ACVRL1
4168:ACVR2B
4163:ACVR2A
4158:ACVR1C
4153:ACVR1B
4136:BMPR1B
4131:BMPR1A
4005:MAP3K7
3990:MAP3K9
3941:MAP3K8
3936:MAP3K7
3931:MAP3K6
3926:MAP3K5
3921:MAP3K4
3916:MAP3K3
3911:MAP3K2
3906:MAP3K1
3880:MAPK14
3875:MAPK13
3870:MAPK11
3858:MAPK10
3836:MAPK15
3831:MAPK12
3723:CDC2L1
3698:CDC2L5
3373:SNF1LK
3198:CAMK2G
3193:CAMK2D
3188:CAMK2B
3183:CAMK2A
3173:CAMK1G
3168:CAMK1D
3163:CAMK1B
3158:CAMK1A
3012:PRKCB1
2949:PRKACA
2944:PRKACB
2939:PRKACG
2915:IKBKAP
2741:BCKDHB
2736:BCKDHA
2710:PRKAG3
2705:PRKAG2
2700:PRKAG1
2690:PRKAB2
2685:PRKAB1
2675:PRKAA2
2670:PRKAA1
2515:STK38L
2405:
2370:
2363:203351
2360:
2342:EMBO J
2327:
2292:
2257:
2222:
2212:
2194:EMBO J
2179:
2144:
2109:
2074:
2044:
2014:
1985:
1950:
1943:189957
1940:
1907:
1900:397938
1897:
1854:
1847:397463
1844:
1801:
1794:551792
1791:
1773:EMBO J
1758:
1737:
1697:
1656:
1621:
1586:
1542:
1484:
1476:
1441:
1312:, and
1286:with:
1253:enzyme
1251:is an
1207:search
1205:PubMed
1052:Q62101
1033:Q15139
929:Entrez
483:BioGPS
62:605435
4607:is a
4458:Types
4214:MAP2K
4148:ACVR1
4141:BMPR2
4126:BMPR1
4051:GSK-3
3892:MAP3K
3853:MAPK9
3848:MAPK8
3826:MAPK7
3821:MAPK6
3816:MAPK4
3811:MAPK3
3806:MAPK1
3718:PFTK1
3713:PCTK3
3708:PCTK2
3703:PCTK1
3693:CDK12
3688:CDK10
3663:CDKL5
3643:CDKL2
3520:STK19
3515:EEF2K
3496:PHKG2
3491:PHKG1
3481:PHKA2
3476:PHKA1
3457:MYLK4
3452:MYLK3
3447:MYLK2
3423:DCLK1
3418:Titin
3408:TRIB3
3403:TRIB2
3398:TRIB1
3388:TSSK2
3368:STK40
3353:PSKH1
3348:PRKD3
3343:PRKD2
3323:PHKG2
3318:PHKG1
3308:OBSCN
3303:NUAK2
3298:NUAK1
3293:MKNK2
3288:MKNK1
3278:MARK4
3273:MARK3
3268:MARK2
3263:MARK1
3243:STK11
3238:DAPK3
3233:DAPK2
3228:DAPK1
3223:CHEK2
3218:CHEK1
3203:CAMK4
3178:CAMK2
3153:CAMK1
3148:BRSK2
3042:PRKCQ
3037:PRKCI
3032:PRKCG
3027:PRKCH
3022:PRKCE
3017:PRKCD
2978:PRKG1
2910:IKBKG
2905:IKBKE
2854:STK10
2849:FASTK
2775:IDH3G
2770:IDH3B
2765:IDH3A
2731:BCKDK
2525:ROCK1
2510:STK38
2505:MAST2
2500:MAST1
2495:LATS2
2490:LATS1
1482:S2CID
1316:YWHAQ
1298:C1QBP
1257:PRKD1
962:18760
922:Mouse
917:Human
888:Amigo
437:fossa
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
170:14q12
107:Human
86:PRKD1
78:55680
70:99879
45:PRKD1
22:PRKD1
4609:stub
4601:gene
4550:list
4543:EC7
4537:list
4530:EC6
4524:list
4517:EC5
4511:list
4504:EC4
4498:list
4491:EC3
4485:list
4478:EC2
4472:list
4465:EC1
4041:TPK1
4017:CDC7
3975:MLKs
3968:KSR2
3963:KSR1
3958:BRAF
3953:ARAF
3948:RAFs
3683:CDK9
3678:CDK8
3673:CDK7
3668:CDK6
3658:CDK5
3653:CDK4
3648:CDK3
3638:CDK2
3633:CDK1
3614:PLK4
3609:PLK3
3604:PLK2
3599:PLK1
3554:PLK4
3549:PLK3
3544:PLK2
3539:PLK1
3486:PHKB
3442:MYLK
3413:TRIO
3383:SPEG
3378:SNRK
3338:PKD1
3333:PIM2
3328:PIM1
3313:PASK
3283:MELK
3213:CASK
3208:MLCK
3129:GRK6
3124:GRK5
3119:GRK4
3057:PKN3
3052:PKN2
2954:PRKY
2900:TBK1
2895:IKK2
2890:CHUK
2794:STK4
2760:IDH2
2645:PDK4
2640:PDK3
2635:PDK2
2630:PDK1
2609:WEE1
2604:Wee1
2572:mTOR
2560:AKT3
2555:AKT2
2550:AKT1
2540:SGK3
2535:SGK2
2403:PMID
2368:PMID
2325:PMID
2290:PMID
2255:PMID
2220:PMID
2177:PMID
2159:Cell
2142:PMID
2107:PMID
2072:PMID
2042:PMID
2012:PMID
1983:PMID
1948:PMID
1905:PMID
1852:PMID
1799:PMID
1760:5668
1756:PMID
1735:PMID
1695:PMID
1654:PMID
1619:PMID
1584:PMID
1540:PMID
1474:PMID
1439:PMID
1260:gene
943:5587
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
4046:TTK
4010:ZAK
2587:HRI
2582:PKR
2530:SGK
2520:CIT
2393:doi
2389:275
2358:PMC
2350:doi
2315:doi
2311:164
2280:doi
2276:275
2245:doi
2241:461
2210:PMC
2202:doi
2167:doi
2132:doi
2128:274
2097:doi
2093:274
2064:doi
2034:doi
2030:242
2004:doi
2000:335
1973:doi
1938:PMC
1930:doi
1895:PMC
1885:doi
1842:PMC
1832:doi
1789:PMC
1781:doi
1752:118
1727:doi
1685:doi
1681:274
1646:doi
1642:310
1611:doi
1607:307
1574:doi
1570:275
1530:doi
1526:461
1466:doi
1429:doi
1425:269
288:End
187:End
90:OMA
66:MGI
4654::
2696:γ
2681:β
2666:α
2454:EC
2448::
2401:.
2387:.
2383:.
2366:.
2356:.
2346:19
2344:.
2340:.
2323:.
2309:.
2305:.
2288:.
2274:.
2270:.
2253:.
2239:.
2235:.
2218:.
2208:.
2198:18
2196:.
2192:.
2175:.
2163:98
2161:.
2157:.
2140:.
2126:.
2122:.
2105:.
2091:.
2087:.
2070:.
2060:14
2058:.
2040:.
2028:.
2010:.
1998:.
1981:.
1967:.
1963:.
1946:.
1936:.
1926:70
1924:.
1920:.
1903:.
1893:.
1883:.
1873:82
1871:.
1867:.
1850:.
1840:.
1830:.
1820:82
1818:.
1814:.
1797:.
1787:.
1775:.
1771:.
1750:.
1733:.
1723:12
1721:.
1693:.
1679:.
1675:.
1652:.
1640:.
1617:.
1605:.
1582:.
1568:.
1564:.
1552:^
1538:.
1524:.
1520:.
1494:^
1480:.
1472:.
1462:89
1460:.
1437:.
1423:.
1419:.
1400:.
1382:.
1353:^
1332:^
1262:.
890:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
4640:e
4633:t
4626:v
4615:.
4566::
4552:)
4548:(
4539:)
4535:(
4526:)
4522:(
4513:)
4509:(
4500:)
4496:(
4487:)
4483:(
4474:)
4470:(
4294:e
4287:t
4280:v
4103:-
4086:-
4069:-
2872:-
2452:(
2438:e
2431:t
2424:v
2409:.
2395::
2374:.
2352::
2331:.
2317::
2296:.
2282::
2261:.
2247::
2226:.
2204::
2183:.
2169::
2148:.
2134::
2113:.
2099::
2078:.
2066::
2048:.
2036::
2018:.
2006::
1989:.
1975::
1969:5
1954:.
1932::
1911:.
1887::
1879::
1858:.
1834::
1826::
1805:.
1783::
1777:9
1762:.
1741:.
1729::
1701:.
1687::
1660:.
1648::
1625:.
1613::
1590:.
1576::
1546:.
1532::
1505:.
1488:.
1468::
1445:.
1431::
1404:.
1386:.
1318:.
1306:,
1300:,
1294:,
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
