Knowledge (XXG)

Proteolipid protein 1

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302: 279: 176: 201: 553: 308: 207: 29: 1163:(CNS). The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus–Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. 2771: 55: 1879:
Kronquist KE, Crandall BF, Macklin WB, Campagnoni AT (1988). "Expression of myelin proteins in the developing human spinal cord: cloning and sequencing of human proteolipid protein cDNA".
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Weimbs T, Dick T, Stoffel W, Boltshauser E (1991). "A point mutation at the X-chromosomal proteolipid protein locus in Pelizaeus-Merzbacher disease leads to disruption of myelinogenesis".
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Pratt VM, Trofatter JA, Schinzel A, et al. (1991). "A new mutation in the proteolipid protein (PLP) gene in a German family with Pelizaeus-Merzbacher disease".
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Mattei MG, Alliel PM, Dautigny A, et al. (1986). "The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome".
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Kahan I, Moscarello MA (1986). "The intramembranous domains of lipophilin in phosphatidylcholine vesicles are similar to those in the myelin membrane".
806: 787: 2487: 2482: 137: 2061:"Pelizaeus-Merzbacher disease: an X-linked neurologic disorder of myelin metabolism with a novel mutation in the gene encoding proteolipid protein" 2235: 2812: 1669:"Pelizaeus-Merzbacher disease: detection of mutations Thr181----Pro and Leu223----Pro in the proteolipid protein gene, and prenatal diagnosis" 2243: 1275: 1257: 2831: 1152:. It is a 4 transmembrane domain protein which is proposed to bind other copies of itself on the extracellular side of the membrane. In a 52: 2454: 1074: 301: 1081: 1149: 278: 1293: 1455:
Woodward K, Malcolm S (1999). "Proteolipid protein gene: Pelizaeus-Merzbacher disease in humans and neurodegeneration in mice".
1799:"Pelizaeus-Merzbacher disease: a valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid" 1595:
Inoue K (2005). "PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2".
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sheath, as the layers of myelin wraps come together, PLP will bind itself and tightly hold the cellular membranes together.
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Edwards, A M; Ross N W; Ulmer J B; Braun P E (Jan 1989). "Interaction of myelin basic protein and proteolipid protein".
117: 1556:"Pelizaeus-Merzbacher disease and spastic paraplegia type 2: two faces of myelin loss from mutations in the same gene" 1179: 314: 213: 2805: 2442: 1137: 1348:
Wood, D D; Vella G J; Moscarello M A (Oct 1984). "Interaction between human myelin basic protein and lipophilin".
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Simons R, Alon N, Riordan JR (1987). "Human myelin DM-20 proteolipid protein deletion defined by cDNA sequence".
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Edwards AM, Ross NW, Ulmer JB, Braun PE (1989). "Interaction of myelin basic protein and proteolipid protein".
851: 125: 1294:"Entrez Gene: PLP1 proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)" 2723: 1159:
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the
832: 2836: 1160: 2798: 2274: 2230: 2474: 2430: 2324: 2144: 2019: 1966: 1810: 1634:"Molecular diagnostics for myelin proteolipid protein gene mutations in Pelizaeus-Merzbacher disease" 1183: 189: 104: 2464: 1057: 1047: 1043: 1039: 1031: 1012: 1008: 978: 974: 964: 960: 956: 952: 933: 929: 1760:
Popot JL, Pham Dinh D, Dautigny A (1991). "Major Myelin proteolipid: the 4-alpha-helix topology".
2220: 2119: 1941: 1904: 1785: 1620: 1583: 1432: 1381: 149: 1035: 1016: 1004: 948: 925: 921: 2201: 2172: 2111: 2082: 2047: 1994: 1933: 1896: 1867: 1838: 1777: 1748: 1719: 1690: 1655: 1612: 1575: 1542: 1507: 1472: 1424: 1416: 1373: 1365: 1330: 97: 45: 2782: 2670: 2665: 2610: 2600: 2595: 2585: 2580: 2575: 2555: 1955:"Mutation of the proteolipid protein gene PLP in a human X chromosome-linked myelin disorder" 2696: 2525: 2505: 2412: 2407: 2402: 2397: 2392: 2387: 2377: 2367: 2362: 2352: 2347: 2270: 2193: 2162: 2152: 2103: 2072: 2037: 2027: 1984: 1974: 1925: 1888: 1859: 1828: 1818: 1769: 1740: 1711: 1680: 1645: 1604: 1567: 1532: 1497: 1464: 1408: 1357: 1320: 552: 394: 325: 269: 224: 2382: 2357: 2133:"Individual exons encode the integral membrane domains of human myelin proteolipid protein" 2309: 2304: 369: 145: 2148: 2023: 1970: 1814: 2077: 2060: 1685: 1668: 1650: 1633: 2167: 2132: 2042: 2008:"Pelizaeus-Merzbacher disease: tight linkage to proteolipid protein gene exon variant" 2007: 1989: 1954: 1468: 721: 716: 711: 706: 701: 696: 691: 686: 681: 676: 671: 666: 661: 656: 640: 635: 630: 625: 609: 604: 599: 594: 28: 2825: 2197: 1863: 1833: 1798: 1325: 1308: 581: 2123: 1945: 1789: 1624: 1587: 1436: 2282: 1908: 1385: 387: 166: 1744: 129: 1571: 153: 2635: 2497: 1502: 1485: 1280:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
470: 2718: 2701: 2299: 1608: 286: 183: 133: 1420: 1369: 2728: 2157: 2032: 1979: 1823: 1715: 1521:"The proteolipid protein gene and myelin disorders in man and animal models" 751: 530: 408: 353: 340: 252: 239: 141: 1616: 1579: 1546: 1511: 1476: 1334: 2205: 2176: 2115: 2086: 2051: 1998: 1937: 1929: 1900: 1892: 1871: 1842: 1781: 1752: 1723: 1694: 1659: 1537: 1520: 1428: 1412: 1377: 1121: 1116: 2686: 2291: 1141: 1105: 896: 877: 1309:"Novel MITF targets identified using a two-step DNA microarray strategy" 2778: 2660: 2655: 2615: 2605: 2590: 2570: 2565: 2560: 2550: 2266: 2107: 1773: 1361: 863: 818: 2770: 74: 2545: 2540: 2535: 2530: 2520: 2515: 2510: 2422: 2278: 1153: 1089: 773: 1555: 108:, GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2, proteolipid protein 1 2711: 2706: 2620: 2372: 2342: 2337: 736: 732: 2738: 2733: 2650: 2640: 2630: 2625: 2435: 2332: 2314: 1195: 121: 2239: 1797:
Pham-Dinh D, Popot JL, Boespflug-Tanguy O, et al. (1991).
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In melanocytic cells PLP1 gene expression may be regulated by
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Strautnieks S, Rutland P, Winter RM, et al. (1992).
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Trofatter JA, Dlouhy SR, DeMyer W, et al. (1990).
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Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008).
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GeneReview/NCBI/NIH/UW entry on PLP1-Related Disorders
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Diehl HJ, Schaich M, Budzinski RM, Stoffel W (1987).
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Hudson LD, Puckett C, Berndt J, et al. (1989).
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Doll R, Natowicz MR, Schiffmann R, Smith FI (1992).
2679: 2496: 2473: 2421: 2323: 2290: 1030: 997: 947: 914: 1236: 1234: 1232: 1215: 1213: 1211: 1519:Yool DA, Edgar JM, Montague P, Malcolm S (2000). 324: 223: 2059:Gencic S, Abuelo D, Ambler M, Hudson LD (1989). 2692:LDL-receptor-related protein-associated protein 1241:GRCm38: Ensembl release 89: ENSMUSG00000031425 2806: 2251: 1484:Garbern J, Cambi F, Shy M, Kamholz J (1999). 8: 1220:GRCh38: Ensembl release 89: ENSG00000123560 2813: 2799: 2258: 2244: 2236: 1027: 944: 747: 702:long-chain fatty acid biosynthetic process 577: 365: 264: 161: 63: 2488:Pulmonary surfactant-associated protein C 2483:Pulmonary surfactant-associated protein B 2223:at the U.S. National Library of Medicine 2166: 2156: 2076: 2041: 2031: 1988: 1978: 1832: 1822: 1684: 1649: 1536: 1501: 1324: 1178:Proteolipid protein 1 has been shown to 1207: 600:structural constituent of myelin sheath 682:positive regulation of gene expression 18: 2752:other cell membrane protein disorders 329: 290: 285: 228: 187: 182: 7: 2767: 2765: 2455:Myelin oligodendrocyte glycoprotein 662:integrin-mediated signaling pathway 2785:. You can help Knowledge (XXG) by 994: 911: 887: 868: 842: 823: 797: 778: 712:central nervous system myelination 547: 465: 403: 382: 14: 16:Type of myelin-associated protein 2769: 1326:10.1111/j.1755-148X.2008.00505.x 551: 427:inferior ganglion of vagus nerve 313: 306: 300: 277: 212: 205: 199: 174: 27: 2724:Phospholipid transfer proteins 2460:Myelin-associated glycoprotein 1356:(10). UNITED STATES: 1523–31. 717:chemical synaptic transmission 626:integral component of membrane 562:More reference expression data 531:More reference expression data 1: 1852:Biochem. Biophys. Res. Commun 1745:10.1515/bchm3.1990.371.2.1175 1469:10.1016/S0168-9525(99)01716-3 722:neuron projection development 298: 197: 2198:10.1016/0005-2736(86)90487-6 2137:Proc. Natl. Acad. Sci. U.S.A 2012:Proc. Natl. Acad. Sci. U.S.A 1959:Proc. Natl. Acad. Sci. U.S.A 1864:10.1016/0006-291X(87)90580-8 1803:Proc. Natl. Acad. Sci. U.S.A 1572:10.1177/08830738030180090801 1407:(1). UNITED STATES: 97–102. 1150:Pelizaeus–Merzbacher disease 707:substantia nigra development 605:structural molecule activity 2832:Genes on human chromosome X 1503:10.1001/archneur.56.10.1210 431:superior vestibular nucleus 2853: 2764: 2443:Myelin proteolipid protein 1138:myelin proteolipid protein 692:glial cell differentiation 489:lateral geniculate nucleus 2747: 1609:10.1007/s10048-004-0207-y 1313:Pigment Cell Melanoma Res 1276:"Mouse PubMed Reference:" 1258:"Human PubMed Reference:" 1120: 1115: 1111: 1104: 1088: 1082:Chr X: 135.72 – 135.74 Mb 1075:Chr X: 103.77 – 103.79 Mb 1069: 1054: 1001: 990: 971: 918: 907: 894: 890: 875: 871: 862: 849: 845: 830: 826: 817: 804: 800: 785: 781: 772: 757: 750: 746: 730: 610:identical protein binding 580: 576: 559: 550: 541: 528: 513:medial geniculate nucleus 509:medial vestibular nucleus 477: 468: 415: 406: 376: 368: 364: 347: 334: 297: 276: 267: 263: 246: 233: 196: 173: 164: 160: 115: 112: 102: 95: 90: 71: 66: 49: 44: 39: 35: 26: 21: 2225:Medical Subject Headings 1733:Biol. Chem. Hoppe-Seyler 505:dorsal tegmental nucleus 2158:10.1073/pnas.83.24.9807 2033:10.1073/pnas.86.23.9427 1980:10.1073/pnas.86.20.8128 1824:10.1073/pnas.88.17.7562 1716:10.1002/ajmg.1320380129 2781:-related article is a 2186:Biochim. Biophys. Acta 1161:central nervous system 493:ventral tegmental area 485:deep cerebellar nuclei 443:ventral tegmental area 2275:Cell surface receptor 1930:10.1002/jnr.490220113 1893:10.1002/jnr.490180303 1413:10.1002/jnr.490220113 1134:Proteolipid protein 1 687:inflammatory response 667:astrocyte development 2475:Pulmonary surfactant 2431:Myelin basic protein 2325:Membrane-spanning 4A 1184:Myelin basic protein 1148:are associated with 1136:(PLP1) is a form of 501:lateral hypothalamus 419:middle frontal gyrus 292:X chromosome (mouse) 190:X chromosome (human) 67:List of PDB id codes 40:Available structures 2465:Myelin protein zero 2221:PLP1+protein,+human 2149:1986PNAS...83.9807D 2024:1989PNAS...86.9427T 1971:1989PNAS...86.8128H 1815:1991PNAS...88.7562P 1538:10.1093/hmg/9.6.987 439:subthalamic nucleus 331:X F1|X 59.1 cM 2108:10.1007/BF00290964 1774:10.1007/BF01868534 1554:Hudson LD (2003). 1362:10.1007/BF00964678 852:ENSMUSG00000031425 650:Biological process 619:Cellular component 588:Molecular function 2794: 2793: 2759: 2758: 2271:membrane proteins 2065:Am. J. Hum. Genet 1704:Am. J. Med. Genet 1673:Am. J. Hum. Genet 1638:Am. J. Hum. Genet 1131: 1130: 1127: 1126: 1100: 1099: 1065: 1064: 1024: 1023: 986: 985: 941: 940: 903: 902: 884: 883: 858: 857: 839: 838: 813: 812: 794: 793: 742: 741: 657:axon ensheathment 572: 571: 568: 567: 537: 536: 524: 523: 517:nucleus accumbens 462: 461: 360: 359: 259: 258: 86: 85: 82: 81: 50:Ortholog search: 2844: 2815: 2808: 2801: 2773: 2766: 2260: 2253: 2246: 2237: 2209: 2180: 2170: 2160: 2127: 2090: 2080: 2055: 2045: 2035: 2002: 1992: 1982: 1949: 1918:J. Neurosci. Res 1912: 1881:J. Neurosci. Res 1875: 1846: 1836: 1826: 1793: 1756: 1727: 1698: 1688: 1663: 1653: 1628: 1591: 1550: 1540: 1515: 1505: 1480: 1441: 1440: 1401:J. Neurosci. Res 1396: 1390: 1389: 1345: 1339: 1338: 1328: 1304: 1298: 1297: 1290: 1284: 1283: 1272: 1266: 1265: 1254: 1248: 1238: 1227: 1217: 1113: 1112: 1084: 1077: 1060: 1028: 1019: 995: 991:RefSeq (protein) 981: 945: 936: 912: 888: 869: 843: 824: 798: 779: 748: 677:axon development 578: 564: 555: 548: 533: 473: 471:Top expressed in 466: 411: 409:Top expressed in 404: 383: 366: 356: 343: 332: 317: 310: 304: 293: 281: 265: 255: 242: 231: 216: 209: 203: 192: 178: 162: 156: 154:PLP1 - orthologs 107: 100: 77: 64: 58: 37: 36: 31: 19: 2852: 2851: 2847: 2846: 2845: 2843: 2842: 2841: 2822: 2821: 2820: 2819: 2762: 2760: 2755: 2743: 2697:Neurofibromin 2 2680:Other/ungrouped 2675: 2492: 2469: 2417: 2319: 2286: 2264: 2217: 2212: 2183: 2143:(24): 9807–11. 2130: 2093: 2058: 2018:(23): 9427–30. 2005: 1965:(20): 8128–31. 1952: 1915: 1878: 1849: 1796: 1759: 1739:(12): 1175–83. 1730: 1701: 1666: 1631: 1594: 1560:J. Child Neurol 1553: 1525:Hum. Mol. Genet 1518: 1483: 1454: 1450: 1448:Further reading 1445: 1444: 1398: 1397: 1393: 1347: 1346: 1342: 1306: 1305: 1301: 1292: 1291: 1287: 1274: 1273: 1269: 1256: 1255: 1251: 1239: 1230: 1218: 1209: 1204: 1192: 1176: 1122:View/Edit Mouse 1117:View/Edit Human 1080: 1073: 1070:Location (UCSC) 1056: 1050: 1046: 1042: 1038: 1034: 1015: 1011: 1007: 1003: 977: 973: 967: 963: 959: 955: 951: 932: 928: 924: 920: 833:ENSG00000123560 726: 697:cell maturation 645: 636:plasma membrane 614: 595:protein binding 560: 529: 520: 515: 511: 507: 503: 499: 495: 491: 487: 483: 481:globus pallidus 469: 458: 455:pars reticulata 453: 449: 445: 441: 437: 433: 429: 425: 423:corpus callosum 421: 407: 351: 338: 330: 320: 319: 318: 311: 291: 268:Gene location ( 250: 237: 229: 219: 218: 217: 210: 188: 165:Gene location ( 116: 103: 96: 73: 51: 17: 12: 11: 5: 2850: 2848: 2840: 2839: 2834: 2824: 2823: 2818: 2817: 2810: 2803: 2795: 2792: 2791: 2774: 2757: 2756: 2748: 2745: 2744: 2742: 2741: 2736: 2731: 2726: 2721: 2716: 2715: 2714: 2709: 2699: 2694: 2689: 2683: 2681: 2677: 2676: 2674: 2673: 2668: 2663: 2658: 2653: 2648: 2643: 2638: 2633: 2628: 2623: 2618: 2613: 2608: 2603: 2598: 2593: 2588: 2583: 2578: 2573: 2568: 2563: 2558: 2553: 2548: 2543: 2538: 2533: 2528: 2523: 2518: 2513: 2508: 2502: 2500: 2494: 2493: 2491: 2490: 2485: 2479: 2477: 2471: 2470: 2468: 2467: 2462: 2457: 2452: 2451: 2450: 2440: 2439: 2438: 2427: 2425: 2419: 2418: 2416: 2415: 2410: 2405: 2400: 2395: 2390: 2385: 2380: 2375: 2370: 2365: 2360: 2355: 2350: 2345: 2340: 2335: 2329: 2327: 2321: 2320: 2318: 2317: 2312: 2307: 2302: 2296: 2294: 2288: 2287: 2265: 2263: 2262: 2255: 2248: 2240: 2234: 2233: 2228: 2216: 2215:External links 2213: 2211: 2210: 2181: 2128: 2091: 2056: 2003: 1950: 1913: 1887:(3): 395–401. 1876: 1847: 1809:(17): 7562–6. 1794: 1762:J. Membr. Biol 1757: 1728: 1699: 1664: 1629: 1592: 1551: 1516: 1496:(10): 1210–4. 1481: 1451: 1449: 1446: 1443: 1442: 1391: 1350:Neurochem. Res 1340: 1299: 1285: 1267: 1249: 1228: 1206: 1205: 1203: 1200: 1199: 1198: 1191: 1188: 1175: 1172: 1129: 1128: 1125: 1124: 1119: 1109: 1108: 1102: 1101: 1098: 1097: 1095: 1093: 1086: 1085: 1078: 1071: 1067: 1066: 1063: 1062: 1052: 1051: 1025: 1022: 1021: 999: 998: 992: 988: 987: 984: 983: 969: 968: 942: 939: 938: 916: 915: 909: 905: 904: 901: 900: 892: 891: 885: 882: 881: 873: 872: 866: 860: 859: 856: 855: 847: 846: 840: 837: 836: 828: 827: 821: 815: 814: 811: 810: 802: 801: 795: 792: 791: 783: 782: 776: 770: 769: 764: 759: 755: 754: 744: 743: 740: 739: 728: 727: 725: 724: 719: 714: 709: 704: 699: 694: 689: 684: 679: 674: 669: 664: 659: 653: 651: 647: 646: 644: 643: 638: 633: 628: 622: 620: 616: 615: 613: 612: 607: 602: 597: 591: 589: 585: 584: 574: 573: 570: 569: 566: 565: 557: 556: 545: 539: 538: 535: 534: 526: 525: 522: 521: 519: 518: 514: 510: 506: 502: 498: 497:pontine nuclei 494: 490: 486: 482: 478: 475: 474: 463: 460: 459: 457: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 416: 413: 412: 400: 399: 391: 380: 374: 373: 370:RNA expression 362: 361: 358: 357: 349: 345: 344: 336: 333: 328: 322: 321: 312: 305: 299: 295: 294: 289: 283: 282: 274: 273: 261: 260: 257: 256: 248: 244: 243: 235: 232: 227: 221: 220: 211: 204: 198: 194: 193: 186: 180: 179: 171: 170: 158: 157: 114: 110: 109: 101: 93: 92: 88: 87: 84: 83: 80: 79: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 2849: 2838: 2837:Protein stubs 2835: 2833: 2830: 2829: 2827: 2816: 2811: 2809: 2804: 2802: 2797: 2796: 2790: 2788: 2784: 2780: 2775: 2772: 2768: 2763: 2754: 2753: 2746: 2740: 2737: 2735: 2732: 2730: 2727: 2725: 2722: 2720: 2717: 2713: 2710: 2708: 2705: 2704: 2703: 2700: 2698: 2695: 2693: 2690: 2688: 2685: 2684: 2682: 2678: 2672: 2669: 2667: 2664: 2662: 2659: 2657: 2654: 2652: 2649: 2647: 2644: 2642: 2639: 2637: 2634: 2632: 2629: 2627: 2624: 2622: 2619: 2617: 2614: 2612: 2609: 2607: 2604: 2602: 2599: 2597: 2594: 2592: 2589: 2587: 2584: 2582: 2579: 2577: 2574: 2572: 2569: 2567: 2564: 2562: 2559: 2557: 2554: 2552: 2549: 2547: 2544: 2542: 2539: 2537: 2534: 2532: 2529: 2527: 2524: 2522: 2519: 2517: 2514: 2512: 2509: 2507: 2504: 2503: 2501: 2499: 2495: 2489: 2486: 2484: 2481: 2480: 2478: 2476: 2472: 2466: 2463: 2461: 2458: 2456: 2453: 2449: 2446: 2445: 2444: 2441: 2437: 2434: 2433: 2432: 2429: 2428: 2426: 2424: 2420: 2414: 2411: 2409: 2406: 2404: 2401: 2399: 2396: 2394: 2391: 2389: 2386: 2384: 2381: 2379: 2376: 2374: 2371: 2369: 2366: 2364: 2361: 2359: 2356: 2354: 2351: 2349: 2346: 2344: 2341: 2339: 2336: 2334: 2331: 2330: 2328: 2326: 2322: 2316: 2313: 2311: 2308: 2306: 2303: 2301: 2298: 2297: 2295: 2293: 2289: 2284: 2280: 2276: 2272: 2268: 2261: 2256: 2254: 2249: 2247: 2242: 2241: 2238: 2232: 2229: 2226: 2222: 2219: 2218: 2214: 2207: 2203: 2199: 2195: 2191: 2187: 2182: 2178: 2174: 2169: 2164: 2159: 2154: 2150: 2146: 2142: 2138: 2134: 2129: 2125: 2121: 2117: 2113: 2109: 2105: 2101: 2097: 2092: 2088: 2084: 2079: 2074: 2071:(3): 435–42. 2070: 2066: 2062: 2057: 2053: 2049: 2044: 2039: 2034: 2029: 2025: 2021: 2017: 2013: 2009: 2004: 2000: 1996: 1991: 1986: 1981: 1976: 1972: 1968: 1964: 1960: 1956: 1951: 1947: 1943: 1939: 1935: 1931: 1927: 1924:(1): 97–102. 1923: 1919: 1914: 1910: 1906: 1902: 1898: 1894: 1890: 1886: 1882: 1877: 1873: 1869: 1865: 1861: 1858:(2): 666–71. 1857: 1853: 1848: 1844: 1840: 1835: 1830: 1825: 1820: 1816: 1812: 1808: 1804: 1800: 1795: 1791: 1787: 1783: 1779: 1775: 1771: 1768:(3): 233–46. 1767: 1763: 1758: 1754: 1750: 1746: 1742: 1738: 1734: 1729: 1725: 1721: 1717: 1713: 1709: 1705: 1700: 1696: 1692: 1687: 1682: 1678: 1674: 1670: 1665: 1661: 1657: 1652: 1647: 1643: 1639: 1635: 1630: 1626: 1622: 1618: 1614: 1610: 1606: 1602: 1598: 1597:Neurogenetics 1593: 1589: 1585: 1581: 1577: 1573: 1569: 1566:(9): 616–24. 1565: 1561: 1557: 1552: 1548: 1544: 1539: 1534: 1531:(6): 987–92. 1530: 1526: 1522: 1517: 1513: 1509: 1504: 1499: 1495: 1491: 1487: 1482: 1478: 1474: 1470: 1466: 1462: 1458: 1453: 1452: 1447: 1438: 1434: 1430: 1426: 1422: 1418: 1414: 1410: 1406: 1402: 1395: 1392: 1387: 1383: 1379: 1375: 1371: 1367: 1363: 1359: 1355: 1351: 1344: 1341: 1336: 1332: 1327: 1322: 1319:(6): 665–76. 1318: 1314: 1310: 1303: 1300: 1295: 1289: 1286: 1281: 1277: 1271: 1268: 1263: 1259: 1253: 1250: 1246: 1242: 1237: 1235: 1233: 1229: 1225: 1221: 1216: 1214: 1212: 1208: 1201: 1197: 1194: 1193: 1189: 1187: 1185: 1181: 1173: 1171: 1169: 1164: 1162: 1157: 1155: 1151: 1147: 1143: 1139: 1135: 1123: 1118: 1114: 1110: 1107: 1103: 1096: 1094: 1091: 1087: 1083: 1079: 1076: 1072: 1068: 1061: 1059: 1053: 1049: 1045: 1041: 1037: 1033: 1029: 1026: 1020: 1018: 1014: 1010: 1006: 1000: 996: 993: 989: 982: 980: 976: 970: 966: 962: 958: 954: 950: 946: 943: 937: 935: 931: 927: 923: 917: 913: 910: 908:RefSeq (mRNA) 906: 899: 898: 893: 889: 886: 880: 879: 874: 870: 867: 865: 861: 854: 853: 848: 844: 841: 835: 834: 829: 825: 822: 820: 816: 809: 808: 803: 799: 796: 790: 789: 784: 780: 777: 775: 771: 768: 765: 763: 760: 756: 753: 749: 745: 738: 734: 729: 723: 720: 718: 715: 713: 710: 708: 705: 703: 700: 698: 695: 693: 690: 688: 685: 683: 680: 678: 675: 673: 670: 668: 665: 663: 660: 658: 655: 654: 652: 649: 648: 642: 639: 637: 634: 632: 631:myelin sheath 629: 627: 624: 623: 621: 618: 617: 611: 608: 606: 603: 601: 598: 596: 593: 592: 590: 587: 586: 583: 582:Gene ontology 579: 575: 563: 558: 554: 549: 546: 544: 540: 532: 527: 516: 512: 508: 504: 500: 496: 492: 488: 484: 480: 479: 476: 472: 467: 464: 454: 450: 446: 442: 438: 434: 430: 426: 422: 418: 417: 414: 410: 405: 402: 401: 398: 396: 392: 390: 389: 385: 384: 381: 379: 375: 371: 367: 363: 355: 350: 346: 342: 337: 327: 323: 316: 309: 303: 296: 288: 284: 280: 275: 271: 266: 262: 254: 249: 245: 241: 236: 226: 222: 215: 208: 202: 195: 191: 185: 181: 177: 172: 168: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 111: 106: 99: 94: 89: 78: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 2787:expanding it 2776: 2761: 2749: 2447: 2283:cytoskeleton 2273:(other than 2192:(1): 223–6. 2189: 2185: 2140: 2136: 2102:(4): 352–3. 2099: 2095: 2068: 2064: 2015: 2011: 1962: 1958: 1921: 1917: 1884: 1880: 1855: 1851: 1806: 1802: 1765: 1761: 1736: 1732: 1710:(1): 136–9. 1707: 1703: 1679:(4): 871–8. 1676: 1672: 1644:(1): 161–9. 1641: 1637: 1600: 1596: 1563: 1559: 1528: 1524: 1493: 1490:Arch. Neurol 1489: 1463:(4): 125–8. 1460: 1457:Trends Genet 1456: 1404: 1400: 1394: 1353: 1349: 1343: 1316: 1312: 1302: 1288: 1279: 1270: 1261: 1252: 1177: 1174:Interactions 1165: 1158: 1145: 1133: 1132: 1058:NP_001346049 1055: 1048:NP_001346048 1044:NP_001346047 1040:NP_001346046 1032:NP_001277490 1013:NP_001291933 1009:NP_001122306 1002: 979:NM_001359120 975:NM_001359119 972: 965:NM_001359118 961:NM_001359117 957:NM_001290562 953:NM_001290561 934:NM_001305004 930:NM_001128834 919: 895: 876: 850: 831: 805: 786: 766: 761: 393: 386: 352:135,740,482 339:135,723,420 251:103,792,619 238:103,773,718 113:External IDs 72: 2498:Tetraspanin 1603:(1): 1–16. 672:myelination 447:spinal cord 91:Identifiers 2826:Categories 2702:Presenilin 2096:Hum. Genet 1247:, May 2017 1226:, May 2017 1202:References 451:C1 segment 397:(ortholog) 134:HomoloGene 2750:see also 2729:Dysferlin 1421:0360-4012 1370:0364-3190 1142:Mutations 1036:NP_035253 1017:NP_955772 1005:NP_000524 949:NM_011123 926:NM_000533 922:NM_199478 752:Orthologs 142:GeneCards 2687:Calnexin 2292:Arrestin 2124:35833817 1946:33666906 1790:24450880 1625:32631043 1617:15627202 1588:38917872 1580:14572140 1547:10767322 1512:10520936 1477:10203813 1437:33666906 1335:19067971 1243:– 1222:– 1190:See also 1180:interact 1106:Wikidata 731:Sources: 641:membrane 2779:protein 2671:TSPAN34 2666:TSPAN33 2661:TSPAN32 2656:TSPAN31 2651:TSPAN30 2646:TSPAN29 2641:TSPAN28 2636:TSPAN27 2631:TSPAN26 2626:TSPAN25 2621:TSPAN24 2616:TSPAN23 2611:TSPAN22 2606:TSPAN21 2601:TSPAN20 2596:TSPAN19 2591:TSPAN18 2586:TSPAN17 2581:TSPAN16 2576:TSPAN15 2571:TSPAN14 2566:TSPAN13 2561:TSPAN12 2556:TSPAN11 2551:TSPAN10 2279:enzymes 2269:: cell 2267:Protein 2206:3768366 2177:3467339 2145:Bibcode 2116:3457761 2087:2773936 2078:1683421 2052:2480601 2020:Bibcode 1999:2479017 1967:Bibcode 1938:2467009 1909:4367384 1901:2449536 1872:2441695 1843:1715570 1811:Bibcode 1782:1711121 1753:1708672 1724:1707231 1695:1384324 1686:1682779 1660:1376966 1651:1682866 1429:2467009 1386:9751765 1378:6083474 1245:Ensembl 1224:Ensembl 1140:(PLP). 864:UniProt 819:Ensembl 758:Species 737:QuickGO 372:pattern 98:Aliases 2546:TSPAN9 2541:TSPAN8 2536:TSPAN7 2531:TSPAN6 2526:TSPAN5 2521:TSPAN4 2516:TSPAN3 2511:TSPAN2 2506:TSPAN1 2423:Myelin 2413:MS4A18 2408:MS4A15 2403:MS4A14 2398:MS4A13 2393:MS4A12 2388:MS4A10 2378:MS4A8B 2368:MS4A6E 2363:MS4A6A 2353:MS4A4E 2348:MS4A4A 2281:, and 2227:(MeSH) 2204:  2175:  2168:387231 2165:  2122:  2114:  2085:  2075:  2050:  2043:298509 2040:  1997:  1990:298228 1987:  1944:  1936:  1907:  1899:  1870:  1841:  1831:  1788:  1780:  1751:  1722:  1693:  1683:  1658:  1648:  1623:  1615:  1586:  1578:  1545:  1510:  1475:  1435:  1427:  1419:  1384:  1376:  1368:  1333:  1154:myelin 1092:search 1090:PubMed 897:P60202 878:P60201 774:Entrez 543:BioGPS 230:Xq22.2 122:300401 2777:This 2712:PSEN2 2707:PSEN1 2383:MS4A9 2373:MS4A7 2358:MS4A5 2343:MS4A3 2338:MS4A2 2333:MS4A1 2310:ARRB2 2305:ARRB1 2120:S2CID 1942:S2CID 1905:S2CID 1834:52341 1786:S2CID 1621:S2CID 1584:S2CID 1433:S2CID 1382:S2CID 1182:with 807:18823 767:Mouse 762:Human 733:Amigo 395:Mouse 388:Human 335:Start 270:Mouse 234:Start 167:Human 130:97623 2783:stub 2739:OTOF 2734:STRC 2448:PLP1 2436:PMP2 2315:ARR3 2202:PMID 2173:PMID 2112:PMID 2083:PMID 2048:PMID 1995:PMID 1934:PMID 1897:PMID 1868:PMID 1839:PMID 1778:PMID 1749:PMID 1720:PMID 1691:PMID 1656:PMID 1613:PMID 1576:PMID 1543:PMID 1508:PMID 1473:PMID 1425:PMID 1417:ISSN 1374:PMID 1366:ISSN 1331:PMID 1196:PLP2 1168:MITF 1146:PLP1 788:5354 435:pons 378:Bgee 326:Band 287:Chr. 225:Band 184:Chr. 146:PLP1 118:OMIM 105:PLP1 75:2XPG 56:RCSB 53:PDBe 22:PLP1 2719:HFE 2300:SAG 2194:doi 2190:862 2163:PMC 2153:doi 2104:doi 2073:PMC 2038:PMC 2028:doi 1985:PMC 1975:doi 1926:doi 1889:doi 1860:doi 1856:146 1829:PMC 1819:doi 1770:doi 1766:120 1741:doi 1737:371 1712:doi 1681:PMC 1646:PMC 1605:doi 1568:doi 1533:doi 1498:doi 1465:doi 1409:doi 1358:doi 1321:doi 1144:in 348:End 247:End 150:OMA 138:448 126:MGI 46:PDB 2828:: 2277:, 2200:. 2188:. 2171:. 2161:. 2151:. 2141:83 2139:. 2135:. 2118:. 2110:. 2100:72 2098:. 2081:. 2069:45 2067:. 2063:. 2046:. 2036:. 2026:. 2016:86 2014:. 2010:. 1993:. 1983:. 1973:. 1963:86 1961:. 1957:. 1940:. 1932:. 1922:22 1920:. 1903:. 1895:. 1885:18 1883:. 1866:. 1854:. 1837:. 1827:. 1817:. 1807:88 1805:. 1801:. 1784:. 1776:. 1764:. 1747:. 1735:. 1718:. 1708:38 1706:. 1689:. 1677:51 1675:. 1671:. 1654:. 1642:51 1640:. 1636:. 1619:. 1611:. 1599:. 1582:. 1574:. 1564:18 1562:. 1558:. 1541:. 1527:. 1523:. 1506:. 1494:56 1492:. 1488:. 1471:. 1461:15 1459:. 1431:. 1423:. 1415:. 1405:22 1403:. 1380:. 1372:. 1364:. 1352:. 1329:. 1317:21 1315:. 1311:. 1278:. 1260:. 1231:^ 1210:^ 1186:. 1170:. 735:/ 354:bp 341:bp 253:bp 240:bp 148:; 144:: 140:; 136:: 132:; 128:: 124:; 120:: 2814:e 2807:t 2800:v 2789:. 2285:) 2259:e 2252:t 2245:v 2208:. 2196:: 2179:. 2155:: 2147:: 2126:. 2106:: 2089:. 2054:. 2030:: 2022:: 2001:. 1977:: 1969:: 1948:. 1928:: 1911:. 1891:: 1874:. 1862:: 1845:. 1821:: 1813:: 1792:. 1772:: 1755:. 1743:: 1726:. 1714:: 1697:. 1662:. 1627:. 1607:: 1601:6 1590:. 1570:: 1549:. 1535:: 1529:9 1514:. 1500:: 1479:. 1467:: 1439:. 1411:: 1388:. 1360:: 1354:9 1337:. 1323:: 1296:. 1282:. 1264:. 272:) 169:) 152::

Index


PDB
PDBe
RCSB
2XPG
Aliases
PLP1
OMIM
300401
MGI
97623
HomoloGene
448
GeneCards
PLP1
OMA
PLP1 - orthologs
Human
X chromosome (human)
Chr.
X chromosome (human)
X chromosome (human)
Genomic location for PLP1
Genomic location for PLP1
Band
bp
bp
Mouse
X chromosome (mouse)
Chr.

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