1352:
and the expression of RANK in bone cells may be the biological presentation of Paget's seed and soil idea. The affinity for RANK of RANKL may be the reason these cancers tend to metastasize to bone. Once the tumor is seeded in the bone, the tumor cells stimulate bone resorption by secreting factors such as RANKL or prompting the surrounding stroma to express growth factors. These growth factors then upregulate production of RANKL which leads to osteoclastogenesis and bone destruction. The destruction of bone releases more growth factors and RANKL which induces more osteoclastogenesis, triggering a vicious cycle of bone destruction that is seen in metastatic bone tumors.
316:
293:
1320:
osteoclasts. This system is balanced by the relative expression of OPG to RANKL, which are highly regulated by many factors including hormones, immune signals, and growth factors. An overexpression of RANKL can cause an overproduction and activation of osteoclasts, which break down bone. The balance between RANKL and OPG is a target for therapy in many diseases including estrogen deficiency-associated osteoporosis, rheumatoid arthritis, Paget's disease, periodontal disease, and bone tumors and malignancies.
190:
215:
567:
322:
221:
43:
1329:
levels of RANKL. It has also been shown to be a critical mediator of fever response to lipopolysaccharide-induced fever and pro-inflammatory cytokines IL-1B and TNFa. This key role of the RANK-RANKL system may link the osteoporosis and hot flashes seen as symptoms of hormonal changes in post-menopausal women.
1957:
Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, von
Haeseler A, Bader M, Kilic SS, Ueta Y, Pifl C, Narumiya S, Penninger JM (26 November 2009). "Central control of fever and
1351:
RANK and RANKL have been reported to be expressed in some breast cancer and prostate cancer cell lines. RANKL expression in infiltrating T cells within mammary carcinomas activate RANK-expressing neoplastic mammary epithelial cells which stimulate metastasis. The expression of RANKL in these cells
1328:
RANK has also been shown to be a key in the thermoregulation signaling in females, which seems to be regulated by ovarian sex hormones. RANK is expressed in key regions of the brain associated with thermoregulation. Inactivation of RANK in these regions causes a loss of fever response to increased
1302:
The binding of RANKL to RANK trimerizes the receptor and activates a signaling pathway. The RANK-RANKL complex forms a heterohexameric complex. Only two of the four RANK CRDs are in direct contact with the RANKL. The majority of the complex's residues are hydrophilic. Unlike other members of the
1319:
has been shown to be imperative to the RANK-related osteoclastogenesis pathway. RANKL binds to RANK, which then binds to TRAF6. TRAF6 stimulates the activation of the c-jun N-terminal kinase (JNK) and nuclear factor kappa-b (NF-κB) pathways which trigger differentiation and activation of
1337:
RANK is constitutively expressed in mammary epithelial tissues. Calcium transferred from mother to fetus and neonate is provided by the degradation of the female bone by increased osteoclastic activity, which is regulated by the RANK/RANKL axis. RANKL also works through RANK to provide
1338:
proliferative and survival signals to promote the final stages of lactating mammary gland development. Dysfunctional RANK or RANKL causes the arrest of differentiation and expansion of the alveolar bunds into mature lobulo-alveolar mammary structures, disabling the production of milk.
1749:
Bridavsky M, Kuhl H, Woodruff A, Kornak U, Timmermann B, Mages N, 99 Lives
Consortium, Lupiáñez DG, Symmons O, Ibrahim DM (22 February 2019). "Crowdfunded whole-genome sequencing of the celebrity cat Lil BUB identifies causal mutations for her osteopetrosis and polydactyly".
1360:
Most therapies that target the RANK/RANKL/OPG axis aim to either down-regulate expression of RANKL or upregulate the expression of the decoy receptor OPG. For example, denosumab is a fully human monoclonal antibody that is directed against RANKL. In phase I and II trials,
69:
1298:
There are two monomers of RANK related by noncrystallographic 2-fold symmetry perpendicular to the long axis of the molecules in the asymmetric unit. RANK contains four CRDs spanning a length of 100 Angstroms which makes it the longest member of the TNFR family to date.
1365:
led to a decrease in bone resorption in multiple myeloma, prostate cancer and breast cancer patients. Another study looked into developing small mimetics based on the structure of OPG that bind to RANK as well as RANKL and cause defective coupling between the two.
3149:
Guerrini MM, Sobacchi C, Cassani B, Abinun M, Kilic SS, Pangrazio A, Moratto D, Mazzolari E, Clayton-Smith J, Orchard P, Coxon FP, Helfrich MH, Crockett JC, Mellis D, Vellodi A, Tezcan I, Notarangelo LD, Rogers MJ, Vezzoni P, Villa A, Frattini A (2008).
122:, tumor necrosis factor receptor superfamily, member 11a, NFKB activator, CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNF receptor superfamily member 11a, TRANCE-R
2628:
Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L (1997). "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function".
1572:
Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L (1997). "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function".
1287:. Its extracellular domain consists of 184 amino acids, its transmembrane domain has 21 amino acids, and its cytoplasmic domain consists of 383 amino acids. Like other members of the TNFR family, it has four extracellular
2929:
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ (1999).
2719:"Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase"
2212:"Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase"
1256:, mammary gland epithelial cells, prostate, vascular cell, and pancreas. Most commonly, activation of NF-κB is mediated by RANKL, but over-expression of RANK alone is sufficient to activate the NF-κB pathway.
2983:
Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J (1999).
3028:
3108:"In Vivo RANK Signaling Blockade Using the Receptor Activator of NF-κB:Fc Effectively Prevents and Ameliorates Wear Debris-Induced Osteolysis via Osteoclast Depletion Without Inhibiting Osteogenesis"
2822:
Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K (1999). "RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis".
6513:
5872:
4106:
2789:"The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily"
2110:"The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily"
6297:
2896:"Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif"
2258:"Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif"
1233:
differentiation and activation. It is associated with bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development.
3245:
2350:
Romas E, Gillespie MT, Martin TJ (2002). "Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis".
329:
228:
2299:"Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6"
6529:
2556:
Hughes AE, Shearman AM, Weber JL, Barr RJ, Wallace RG, Osterberg PH, Nevin NC, Mollan RA (1994). "Genetic linkage of familial expansile osteolysis to chromosome 18q".
6991:
6457:
5995:
4096:
6579:
1237:(OPG) is a decoy receptor for RANKL, and regulates the stimulation of the RANK signaling pathway by competing for RANKL. The cytoplasmic domain of RANK binds
7011:
5282:
6639:
6290:
4076:
3213:
2009:
Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM (Sep 29, 2000).
915:
2060:"Disabling of Receptor Activator of Nuclear Factor- B (RANK) Receptor Complex by Novel Osteoprotegerin-like Peptidomimetics Restores Bone Loss in Vivo"
896:
151:
5672:
4938:
3262:
3238:
6982:
6971:
6947:
6437:
6243:
5961:
5957:
5940:
4669:
1526:
Sattler AM, Schoppet M, Schaefer JR, Hofbauer LC (2004). "Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease".
6326:
6074:
6049:
5913:
4657:
4435:
7366:
6473:
6283:
6078:
6053:
5904:
4721:
4716:
4662:
4442:
3223:
3106:
Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM (1 February 2002).
1508:
1490:
7371:
6605:
6231:
5930:
5865:
4175:
4101:
3231:
2472:
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Velasco C, Fortun Y, Heymann D, Padrines M (2007). "Key roles of the OPG-RANK-RANKL system in bone oncology".
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Hofbauer LC, Heufelder AE (3 May 2001). "Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology".
2435:
Anandarajah AP, Schwarz EM (2006). "Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications".
5925:
5204:
5199:
5194:
5189:
4116:
2932:"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand"
315:
6337:
1154:
1147:
7291:
5169:
1626:"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families"
1272:
292:
5804:
5509:
5501:
5275:
4405:
3027:
Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RG, van Hul W, Whyte MP, Nakatsuka K, Hovy L, Anderson DM (2000).
6152:
5450:
4973:
4467:
4153:
2515:
1477:
1456:
7002:
6704:
6147:
6095:
5486:
4612:
4148:
1865:
Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, Nakao K, Nakamura K, Katsuki M, Yamamoto T, Inoue J (Jun 1999).
1222:
214:
189:
1473:
66:
5399:
5361:
5356:
5109:
4581:
4576:
4521:
4255:
3704:
1813:
Liu C, Walter TS, Huang P, Zhang S, Zhu X, Wu Y, Wedderburn LR, Tang P, Owens RJ, Stuart DI, Ren J, Gao B (14 May 2010).
1452:
328:
227:
7376:
7306:
5404:
4803:
4526:
1284:
131:
2674:
Haslam SI, Van Hul W, Morales-Piga A, Balemans W, San-Millan JL, Nakatsuka K, Willems P, Haites NE, Ralston SH (1998).
6116:
6112:
5268:
4121:
1375:
321:
220:
5817:
7296:
6938:
6132:
5748:
5304:
4833:
3258:
6897:
6367:
6108:
6032:
5731:
5517:
3699:
6262:
6226:
5757:
4883:
3778:
3204:
1867:"Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice"
960:
139:
2853:"Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase"
2676:"Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity"
2158:"Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase"
6650:
6346:
6181:
6159:
6083:
6070:
6057:
6045:
6013:
6000:
5990:
5966:
5953:
5909:
5900:
5827:
5800:
5791:
5386:
4847:
941:
6362:
1252:
RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland,
7035:
6218:
6142:
5895:
5861:
5852:
5822:
5813:
5796:
5394:
5314:
4190:
4185:
4180:
4170:
3477:
3405:
1714:
Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution".
1295:. RANK is encoded on human chromosome 18q22.1. It shows 85% homology between mouse and human homologues.
2011:"The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development"
6847:
6842:
6793:
5920:
3534:
3452:
203:
27:
6432:
6447:
3073:"TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src"
1783:
Schramek D, Penninger JM (2011). "The many roles of RANKL-RANK signaling in bone, breast and cancer".
6962:
6798:
6503:
6397:
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5948:
5890:
5847:
5774:
4771:
4484:
2943:
2638:
1967:
1751:
1582:
118:
7205:
6913:
6803:
6695:
6412:
6407:
6402:
6392:
6257:
6252:
6090:
4798:
4617:
3029:"Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis"
2297:
Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N (Feb 2002).
1105:
1101:
1097:
1093:
1042:
1038:
1034:
1030:
6666:
6524:
6493:
3152:"Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations"
6827:
6822:
6788:
6783:
6729:
6544:
6317:
6309:
6247:
6018:
5766:
5299:
4205:
3939:
3137:
3059:
2882:
2705:
2662:
2497:
2460:
2381:"Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin"
2187:
2040:
1991:
1939:
1896:
1847:
1762:
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1606:
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159:
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2402:
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2279:
2233:
2179:
2131:
2081:
2032:
1983:
1931:
1888:
1839:
1731:
1688:
1647:
1598:
1543:
111:
59:
7182:
6357:
1727:
6908:
6837:
6832:
6720:
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6206:
6009:
5882:
5723:
5715:
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5608:
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4711:
4632:
4195:
3388:
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3163:
3119:
3084:
3043:
3005:
2997:
2961:
2951:
2907:
2864:
2831:
2800:
2765:
2754:"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor"
2730:
2687:
2646:
2606:
2598:
2565:
2534:
2524:
2481:
2444:
2392:
2359:
2318:
2310:
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2223:
2169:
2121:
2071:
2022:
1975:
1923:
1878:
1829:
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1723:
1678:
1637:
1590:
1535:
408:
339:
283:
238:
6816:
7286:
7263:
6808:
6725:
6488:
5632:
5038:
3574:
3569:
3492:
1429:
1424:
1234:
383:
781:
positive regulation of fever generation by positive regulation of prostaglandin secretion
3200:
2947:
2642:
1971:
1586:
7147:
7137:
7064:
6681:
6671:
6595:
6427:
5533:
4823:
4245:
3756:
3559:
3176:
3151:
2611:
2586:
2539:
2510:
2397:
2380:
3089:
3072:
3010:
2985:
2869:
2852:
2363:
2323:
2298:
2174:
2157:
2156:
Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH (Jan 1999).
2027:
2010:
830:
825:
820:
815:
810:
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633:
628:
623:
618:
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608:
7360:
6715:
6498:
6417:
5985:
5779:
4793:
4250:
3341:
3217:
2966:
2931:
1883:
1866:
1667:"TRANCE is a TNF family member that regulates dendritic cell and osteoclast function"
595:
3141:
3063:
2886:
2709:
2501:
2464:
2191:
2044:
1943:
1766:
1700:
1555:
1259:
RANKL (receptor activator for nuclear factor κ B ligand) is found on the surface of
143:
7321:
7301:
7220:
7210:
7152:
7099:
7029:
6928:
6872:
6559:
6549:
6539:
6442:
6422:
6387:
6382:
6173:
5541:
5149:
4457:
4447:
3978:
3944:
2666:
2314:
1995:
1900:
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1610:
1260:
401:
180:
2851:
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167:
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7230:
7215:
7187:
7177:
7172:
7127:
7094:
7089:
7084:
7079:
7074:
7059:
7054:
6877:
6862:
6857:
6676:
6661:
6478:
5366:
5341:
5159:
4808:
4586:
4561:
4260:
3882:
3808:
3282:
1513:
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Biotechnology Information, U.S. National Library of Medicine
1495:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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2692:
2675:
484:
7167:
7069:
6923:
6468:
5089:
4813:
4494:
4235:
4111:
3744:
3739:
3734:
3589:
3373:
1539:
1264:
1253:
1230:
300:
197:
147:
2805:
2788:
2770:
2753:
2735:
2718:
2485:
2228:
2211:
2126:
2109:
2058:
Cheng X, Kinosaki M, Takami M, Choi Y, Zhang H, Murali R (15 December 2003).
1834:
7341:
7336:
7117:
6564:
5656:
5648:
5640:
4928:
4923:
4918:
4908:
4903:
4898:
4893:
2912:
2895:
2414:
Clohisy DR, Mantyh PW (2005). "Bone cancer pain and the role of RANKL/OPG".
2274:
2257:
1815:"Structural and Functional Insights of RANKL-RANK Interaction and Signaling"
1362:
860:
544:
422:
367:
354:
266:
253:
155:
3185:
3133:
3098:
3055:
3019:
3001:
2975:
2956:
2921:
2878:
2835:
2548:
2493:
2456:
2427:
2406:
2371:
2332:
2283:
2183:
2085:
2076:
2059:
2036:
1987:
1935:
1892:
1843:
1735:
1692:
1651:
1642:
1625:
1547:
1291:-rich pseudo-repeat domains (CRDs). It shares 40% amino acid identity with
786:
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
2843:
2814:
2779:
2744:
2701:
2658:
2620:
2577:
2569:
2237:
2135:
1927:
1602:
1194:
1189:
6569:
5696:
5688:
5680:
5664:
5234:
5134:
4948:
4933:
4136:
4131:
4039:
3729:
1683:
1666:
1288:
1242:
1178:
1005:
986:
1979:
1624:
Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999).
6065:
6061:
5808:
5184:
5179:
5174:
5074:
4888:
4878:
4705:
4684:
4679:
4647:
4452:
4372:
4367:
4362:
4357:
4352:
4270:
3963:
3803:
3798:
3793:
3788:
3783:
3254:
2752:
Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y (1998).
2108:
Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (Dec 1998).
1241:
1, 2, 3, 5, and 6 which transmit signals to downstream targets such as
972:
927:
2448:
88:
7142:
7132:
6777:
6773:
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6761:
6757:
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6163:
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5260:
5124:
5084:
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5053:
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4700:
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4240:
4200:
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4003:
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3917:
3912:
3907:
3902:
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3709:
3694:
3564:
3554:
3517:
3512:
3430:
3425:
1796:
1268:
1162:
882:
1225:(TNFR) molecular sub-family. RANK is the receptor for RANK-Ligand (
2787:
Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (1999).
2602:
2529:
1756:
6812:
6753:
6749:
6745:
6741:
6737:
6733:
6630:
6236:
5856:
5787:
5783:
5573:
5525:
5467:
5431:
5426:
5421:
5416:
5411:
5376:
5336:
5326:
5249:
5224:
5144:
5139:
5129:
5119:
5104:
5099:
5094:
5079:
5033:
5018:
4983:
4968:
4963:
4953:
4873:
4868:
4863:
4842:
4838:
4828:
4741:
4642:
4637:
4596:
4546:
4541:
4536:
4531:
4516:
4509:
4489:
4477:
4420:
4415:
4410:
4400:
4395:
4388:
4326:
4316:
4311:
4306:
4296:
4275:
4265:
4230:
4225:
4220:
4215:
4210:
4165:
4160:
4126:
4091:
4086:
4081:
4071:
4059:
4054:
4034:
4029:
4024:
4019:
3973:
3865:
3860:
3679:
3663:
3656:
3651:
3646:
3641:
3636:
3631:
3606:
3584:
3579:
3472:
3398:
3393:
3383:
3047:
2650:
1594:
1419:
1406:
1400:
1394:
1388:
1382:
1316:
1229:) and part of the RANK/RANKL/OPG signaling pathway that regulates
1226:
20:
845:
841:
7197:
7109:
7046:
5565:
5557:
5549:
5460:
5371:
5351:
5346:
5331:
5322:
5244:
5239:
5229:
5219:
5214:
5209:
5164:
5154:
5114:
5043:
5013:
5008:
5003:
4998:
4993:
4988:
4943:
4818:
4786:
4781:
4761:
4751:
4746:
4731:
4726:
4627:
4622:
4591:
4571:
4566:
4556:
4551:
4430:
4383:
4343:
3998:
3993:
3988:
3983:
3968:
3959:
3954:
3949:
3934:
3892:
3887:
3877:
3872:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3751:
3724:
3719:
3714:
3689:
3684:
3621:
3616:
3611:
3601:
3596:
3549:
3544:
3539:
3529:
3524:
3507:
3502:
3497:
3487:
3482:
3467:
3462:
3457:
3447:
3442:
3437:
3420:
3415:
3410:
3361:
3329:
3324:
3319:
3302:
3297:
3292:
3287:
2587:"Genetic linkage of Paget disease of the bone to chromosome 18q"
1292:
1238:
746:
positive regulation of DNA-binding transcription factor activity
135:
42:
6279:
5264:
3227:
575:
4756:
3368:
3356:
3351:
3346:
3336:
3309:
3277:
2210:
Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB (Aug 1998).
1246:
776:
positive regulation of NF-kappaB transcription factor activity
2986:"RANK is essential for osteoclast and lymph node development"
1303:
TNFSF, each surface interaction in RANK-RANKL is continuous.
2717:
Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB (1998).
23:, the osteoblast cell-surface receptor that binds to RANK.
391:
6438:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
2416:
1271:. Mutations affecting RANK have been associated with
556:
791:
positive regulation of cell population proliferation
7276:
7254:
7196:
7108:
7045:
7028:
7021:
7001:
6981:
6961:
6937:
6896:
6703:
6694:
6649:
6629:
6578:
6512:
6456:
6345:
6336:
6316:
6217:
6172:
6131:
6031:
5977:
5939:
5881:
5838:
5765:
5756:
5747:
5708:
5585:
5494:
5485:
5440:
5385:
5313:
5298:
5062:
4856:
4605:
4289:
4012:
3672:
3270:
2256:Darnay BG, Ni J, Moore PA, Aggarwal BB (Mar 1999).
1123:
1086:
1060:
1023:
1469:
1467:
1465:
1448:
1446:
1444:
619:tumor necrosis factor-activated receptor activity
338:
237:
6530:Granulocyte macrophage colony-stimulating factor
751:tumor necrosis factor-mediated signaling pathway
2894:Darnay BG, Ni J, Moore PA, Aggarwal BB (1999).
2251:
2249:
2247:
2151:
2149:
2147:
2145:
2205:
2203:
2201:
2103:
2101:
2099:
2097:
2095:
1474:GRCm38: Ensembl release 89: ENSMUSG00000026321
6291:
5276:
3239:
2511:"Biology of RANK, RANKL, and osteoprotegerin"
8:
1778:
1776:
1774:
1453:GRCh38: Ensembl release 89: ENSG00000141655
7297:Leukemia/leukocyte inhibitory factor (LIF)
7042:
7025:
6700:
6342:
6298:
6284:
6276:
5762:
5753:
5491:
5310:
5283:
5269:
5261:
3246:
3232:
3224:
3214:United States National Library of Medicine
1567:
1565:
856:
731:positive regulation of JUN kinase activity
591:
379:
278:
175:
77:
7292:FMS-like tyrosine kinase 3 ligand (FLT3L)
6721:Interferon alpha (interferon alfa, IFN-α)
3263:list of human clusters of differentiation
3203:at the U.S. National Library of Medicine
3175:
3123:
3088:
3009:
2965:
2955:
2911:
2868:
2804:
2769:
2734:
2691:
2610:
2538:
2528:
2396:
2322:
2273:
2227:
2173:
2125:
2075:
2026:
1882:
1833:
1755:
1682:
1641:
624:transmembrane signaling receptor activity
7314:Additional cytokine receptor modulators:
3212:This article incorporates text from the
1958:female body temperature by RANKL/RANK".
1728:10.1146/annurev.immunol.20.100301.064753
1207:Receptor activator of nuclear factor κ B
1440:
831:multinuclear osteoclast differentiation
16:Mammalian protein found in Homo sapiens
7138:Cucurbitacin I (elatericin B, JSI-124)
3156:The American Journal of Human Genetics
1808:
1806:
826:positive regulation of bone resorption
32:
6474:Granulocyte colony-stimulating factor
660:integral component of plasma membrane
343:
304:
299:
242:
201:
196:
7:
6833:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
6606:Macrophage colony-stimulating factor
3112:Journal of Bone and Mineral Research
7307:Thymic stromal lymphopoietin (TSLP)
2398:10.1161/01.RES.0000149165.99974.12
1665:Wong BR, Josien R, Choi Y (1999).
1120:
1083:
1057:
1020:
996:
977:
951:
932:
906:
887:
806:TNFSF11-mediated signaling pathway
761:multicellular organism development
756:mammary gland alveolus development
561:
479:
417:
396:
14:
1273:infantile malignant osteopetrosis
766:response to tumor necrosis factor
726:circadian temperature homeostasis
2516:Arthritis Research & Therapy
1884:10.1046/j.1365-2443.1999.00265.x
670:external side of plasma membrane
565:
327:
320:
314:
291:
226:
219:
213:
188:
41:
6838:Interferon omega (IFN-ω, IFNW1)
2064:Journal of Biological Chemistry
696:regulation of apoptotic process
2315:10.1128/mcb.22.4.992-1000.2002
1223:tumor necrosis factor receptor
771:response to lipopolysaccharide
650:integral component of membrane
576:More reference expression data
545:More reference expression data
1:
3090:10.1016/S1097-2765(00)80232-4
2870:10.1016/S0014-5793(98)01731-1
2824:Biochem. Biophys. Res. Commun
2364:10.1016/S8756-3282(01)00682-2
2175:10.1016/S0014-5793(98)01731-1
2028:10.1016/s0092-8674(00)00103-3
1916:Journal of Molecular Medicine
312:
211:
7367:Genes on human chromosome 18
2936:Proc. Natl. Acad. Sci. U.S.A
1285:type I transmembrane protein
7372:Clusters of differentiation
6682:Thrombopoietin (THPO, MGDF)
6448:Pegol sihematide (EPO-018B)
6368:Carbamylated erythropoietin
3259:clusters of differentiation
796:apoptotic signaling pathway
634:signaling receptor activity
7395:
3168:10.1016/j.ajhg.2008.06.015
3125:10.1359/jbmr.2002.17.2.192
2693:10.1359/jbmr.1998.13.6.911
2474:Expert Rev Anticancer Ther
1275:in humans, mice and cats.
736:osteoclast differentiation
457:mucosa of transverse colon
25:
18:
7231:Tofacitinib (tasocitinib)
7188:Tofacitinib (tasocitinib)
7095:Tofacitinib (tasocitinib)
2509:Boyce BF, Xing L (2007).
1822:The Journal of Immunology
1540:10.1007/s00223-003-0011-y
1509:"Mouse PubMed Reference:"
1491:"Human PubMed Reference:"
1333:Mammary gland development
1283:RANK is a 616 amino acid
1193:
1188:
1184:
1177:
1161:
1155:Chr 1: 105.71 – 105.78 Mb
1142:
1127:
1090:
1079:
1064:
1027:
1016:
1003:
999:
984:
980:
971:
958:
954:
939:
935:
926:
913:
909:
894:
890:
881:
866:
859:
855:
839:
706:response to interleukin-1
594:
590:
573:
564:
555:
542:
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
85:
80:
63:
58:
53:
49:
40:
35:
6909:Interferon gamma (IFN-γ)
3205:Medical Subject Headings
2806:10.1074/jbc.273.51.34120
2771:10.1074/jbc.273.43.28355
2736:10.1074/jbc.273.32.20551
2486:10.1586/14737140.7.2.221
2379:Collin-Osdoby P (2005).
2229:10.1074/jbc.273.32.20551
2127:10.1074/jbc.273.51.34120
1835:10.4049/jimmunol.0904033
1148:Chr 18: 62.33 – 62.39 Mb
711:adaptive immune response
19:Not to be confused with
6809:Interferon beta (IFN-β)
2913:10.1074/jbc.274.12.7724
2275:10.1074/jbc.274.12.7724
1374:RANK has been shown to
437:mucosa of sigmoid colon
7287:Cardiotrophin 1 (CT-1)
6219:Enzyme-linked receptor
3002:10.1101/gad.13.18.2412
2957:10.1073/pnas.96.7.3540
2836:10.1006/bbrc.1998.9788
2077:10.1074/jbc.M309690200
1643:10.1210/edrv.20.3.0367
816:lymph node development
511:lumbar spinal ganglion
461:pancreatic ductal cell
7284:Additional cytokines:
7211:Decernotinib (VX-509)
6848:Peginterferon alfa-2b
6843:Peginterferon alfa-2a
6363:Asialo erythropoietin
6041:Interleukin receptors
5949:Interleukin receptors
5891:Interleukin receptors
5848:Interleukin receptors
5775:Interleukin receptors
1928:10.1007/s001090100226
1342:Clinical significance
1221:, is a member of the
811:inflammatory response
801:response to radiation
527:stroma of bone marrow
204:Chromosome 18 (human)
168:TNFRSF11A - orthologs
28:Rank (disambiguation)
6799:Interferon alfacon-1
6428:Erythropoietin (EPO)
6091:Interferon receptors
1684:10.1002/jlb.65.6.715
701:response to cytokine
306:Chromosome 1 (mouse)
81:List of PDB id codes
54:Available structures
26:For other uses, see
7377:TNF receptor family
6946:See IL-28R (IFNLR)
6914:Interferon gamma 1b
6804:Interferon alpha-n3
2948:1999PNAS...96.3540H
2643:1997Natur.390..175A
2570:10.1093/hmg/3.2.359
1980:10.1038/nature08596
1972:2009Natur.462..505H
1587:1997Natur.390..175A
821:signal transduction
741:cell-cell signaling
721:monocyte chemotaxis
503:submandibular gland
469:epithelium of colon
7302:Oncostatin M (OSM)
6828:Interferon beta 1b
6823:Interferon beta 1a
6794:Interferon alfa n1
6789:Interferon alfa 2b
6784:Interferon alfa 2a
6618:Kinase inhibitors:
5300:Chemokine receptor
5292:Cytokine receptors
3216:, which is in the
2680:J. Bone Miner. Res
1716:Annu. Rev. Immunol
1528:Calcif. Tissue Int
1356:Targeted therapies
1312:Osteoclastogenesis
961:ENSMUSG00000026321
689:Biological process
643:Cellular component
602:Molecular function
7354:
7353:
7350:
7349:
7272:
7271:
7039:
6957:
6956:
6690:
6689:
6433:Erythropoietin-Fc
6307:Cytokine receptor
6273:
6272:
6127:
6126:
6027:
6026:
5743:
5742:
5481:
5480:
5258:
5257:
2591:Am. J. Hum. Genet
2449:10.1002/jcb.20674
1966:(7272): 505–509.
1828:(12): 6910–6919.
1581:(6656): 175–179.
1213:), also known as
1204:
1203:
1200:
1199:
1173:
1172:
1138:
1137:
1117:
1116:
1075:
1074:
1054:
1053:
1012:
1011:
993:
992:
967:
966:
948:
947:
922:
921:
903:
902:
851:
850:
609:metal ion binding
586:
585:
582:
581:
551:
550:
538:
537:
476:
475:
374:
373:
273:
272:
100:
99:
96:
95:
64:Ortholog search:
7384:
7043:
7033:
7026:
6885:Decoy receptors:
6701:
6378:Darbepoetin alfa
6343:
6300:
6293:
6286:
6277:
6010:hormone receptor
5763:
5754:
5492:
5311:
5285:
5278:
5271:
5262:
3248:
3241:
3234:
3225:
3189:
3179:
3145:
3127:
3102:
3092:
3067:
3033:
3023:
3013:
2979:
2969:
2959:
2925:
2915:
2890:
2872:
2847:
2818:
2808:
2783:
2773:
2748:
2738:
2713:
2695:
2670:
2624:
2614:
2581:
2552:
2542:
2532:
2505:
2468:
2437:J. Cell. Biochem
2431:
2410:
2400:
2375:
2337:
2336:
2326:
2294:
2288:
2287:
2277:
2253:
2242:
2241:
2231:
2207:
2196:
2195:
2177:
2153:
2140:
2139:
2129:
2105:
2090:
2089:
2079:
2070:(9): 8269–8277.
2055:
2049:
2048:
2030:
2006:
2000:
1999:
1954:
1948:
1947:
1922:(5–6): 243–253.
1911:
1905:
1904:
1886:
1862:
1856:
1855:
1837:
1819:
1810:
1801:
1800:
1797:10.1138/20110512
1780:
1769:
1761:
1759:
1746:
1740:
1739:
1711:
1705:
1704:
1686:
1662:
1656:
1655:
1645:
1621:
1615:
1614:
1569:
1560:
1559:
1523:
1517:
1516:
1505:
1499:
1498:
1487:
1481:
1471:
1460:
1450:
1324:Thermoregulation
1186:
1185:
1157:
1150:
1133:
1121:
1112:
1084:
1080:RefSeq (protein)
1070:
1058:
1049:
1021:
997:
978:
952:
933:
907:
888:
857:
629:cytokine binding
592:
578:
569:
562:
547:
487:
485:Top expressed in
480:
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
121:
114:
91:
78:
72:
51:
50:
45:
33:
7394:
7393:
7387:
7386:
7385:
7383:
7382:
7381:
7357:
7356:
7355:
7346:
7268:
7264:Deucravacitinib
7250:
7192:
7104:
7032:
7017:
6997:
6977:
6953:
6933:
6892:
6726:Interferon alfa
6686:
6645:
6625:
6574:
6508:
6504:Pegnartograstim
6489:Lipegfilgrastim
6452:
6398:Epoetin epsilon
6332:
6312:
6304:
6274:
6269:
6213:
6168:
6123:
6023:
5973:
5935:
5877:
5834:
5739:
5704:
5633:Osteoprotegerin
5581:
5477:
5436:
5381:
5302:
5294:
5289:
5259:
5254:
5058:
4852:
4601:
4285:
4008:
3668:
3266:
3252:
3197:
3192:
3148:
3105:
3070:
3031:
3026:
2996:(18): 2412–24.
2982:
2928:
2906:(12): 7724–31.
2893:
2850:
2821:
2799:(51): 34120–7.
2786:
2764:(43): 28355–9.
2751:
2729:(32): 20551–5.
2716:
2673:
2637:(6656): 175–9.
2627:
2584:
2558:Hum. Mol. Genet
2555:
2523:(Suppl 1): S1.
2508:
2471:
2434:
2413:
2391:(11): 1046–57.
2378:
2349:
2345:
2343:Further reading
2340:
2309:(4): 992–1000.
2303:Mol. Cell. Biol
2296:
2295:
2291:
2268:(12): 7724–31.
2255:
2254:
2245:
2222:(32): 20551–5.
2209:
2208:
2199:
2155:
2154:
2143:
2120:(51): 34120–7.
2107:
2106:
2093:
2057:
2056:
2052:
2008:
2007:
2003:
1956:
1955:
1951:
1913:
1912:
1908:
1864:
1863:
1859:
1817:
1812:
1811:
1804:
1782:
1781:
1772:
1748:
1747:
1743:
1713:
1712:
1708:
1671:J. Leukoc. Biol
1664:
1663:
1659:
1623:
1622:
1618:
1571:
1570:
1563:
1525:
1524:
1520:
1507:
1506:
1502:
1489:
1488:
1484:
1472:
1463:
1451:
1442:
1438:
1430:Osteoimmunology
1425:Osteoprotegerin
1416:
1372:
1358:
1349:
1344:
1335:
1326:
1314:
1309:
1281:
1235:Osteoprotegerin
1215:TRANCE receptor
1195:View/Edit Mouse
1190:View/Edit Human
1153:
1146:
1143:Location (UCSC)
1129:
1108:
1104:
1100:
1096:
1092:
1066:
1045:
1041:
1037:
1033:
1029:
942:ENSG00000141655
835:
684:
680:plasma membrane
638:
614:protein binding
574:
543:
534:
529:
525:
521:
517:
513:
509:
505:
501:
497:
483:
472:
467:
463:
459:
455:
453:mucosa of ileum
451:
447:
443:
439:
435:
421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
87:
65:
31:
24:
17:
12:
11:
5:
7392:
7391:
7388:
7380:
7379:
7374:
7369:
7359:
7358:
7352:
7351:
7348:
7347:
7345:
7344:
7339:
7334:
7329:
7324:
7319:
7310:
7309:
7304:
7299:
7294:
7289:
7280:
7278:
7274:
7273:
7270:
7269:
7267:
7266:
7260:
7258:
7252:
7251:
7249:
7248:
7243:
7238:
7233:
7228:
7223:
7218:
7213:
7208:
7206:Cercosporamide
7202:
7200:
7194:
7193:
7191:
7190:
7185:
7180:
7175:
7170:
7165:
7160:
7155:
7150:
7148:Deuruxolitinib
7145:
7140:
7135:
7130:
7125:
7120:
7114:
7112:
7106:
7105:
7103:
7102:
7097:
7092:
7087:
7082:
7077:
7072:
7067:
7065:Deuruxolitinib
7062:
7057:
7051:
7049:
7040:
7023:
7019:
7018:
7016:
7015:
7007:
7005:
6999:
6998:
6996:
6995:
6987:
6985:
6979:
6978:
6976:
6975:
6967:
6965:
6959:
6958:
6955:
6954:
6952:
6951:
6943:
6941:
6939:IFNLR (λ, III)
6935:
6934:
6932:
6931:
6926:
6917:
6916:
6911:
6902:
6900:
6894:
6893:
6891:
6890:
6881:
6880:
6875:
6870:
6865:
6860:
6851:
6850:
6845:
6840:
6835:
6830:
6825:
6820:
6806:
6801:
6796:
6791:
6786:
6781:
6723:
6718:
6709:
6707:
6705:IFNAR (α/β, I)
6698:
6692:
6691:
6688:
6687:
6685:
6684:
6679:
6674:
6672:Promegapoietin
6669:
6664:
6655:
6653:
6651:Thrombopoietin
6647:
6646:
6644:
6643:
6635:
6633:
6627:
6626:
6624:
6623:
6614:
6613:
6608:
6603:
6598:
6596:Interleukin-34
6593:
6584:
6582:
6576:
6575:
6573:
6572:
6567:
6562:
6553:
6552:
6547:
6542:
6537:
6532:
6527:
6518:
6516:
6510:
6509:
6507:
6506:
6501:
6496:
6491:
6486:
6481:
6476:
6471:
6462:
6460:
6454:
6453:
6451:
6450:
6445:
6440:
6435:
6430:
6425:
6420:
6415:
6410:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6360:
6351:
6349:
6347:Erythropoietin
6340:
6334:
6333:
6331:
6330:
6322:
6320:
6314:
6313:
6305:
6303:
6302:
6295:
6288:
6280:
6271:
6270:
6268:
6267:
6266:
6265:
6260:
6255:
6241:
6240:
6239:
6234:
6223:
6221:
6215:
6214:
6212:
6211:
6210:
6209:
6204:
6199:
6194:
6189:
6178:
6176:
6170:
6169:
6167:
6166:
6157:
6156:
6155:
6150:
6140:
6137:
6135:
6133:Ig superfamily
6129:
6128:
6125:
6124:
6122:
6121:
6120:
6119:
6106:
6088:
6087:
6086:
6081:
6068:
6037:
6035:
6029:
6028:
6025:
6024:
6022:
6021:
6016:
6006:
6005:
6004:
6003:
6001:Thrombopoietin
5998:
5993:
5981:
5979:
5975:
5974:
5972:
5971:
5970:
5969:
5964:
5945:
5943:
5937:
5936:
5934:
5933:
5928:
5923:
5918:
5917:
5916:
5907:
5898:
5887:
5885:
5879:
5878:
5876:
5875:
5870:
5869:
5868:
5859:
5844:
5842:
5836:
5835:
5833:
5832:
5831:
5830:
5825:
5820:
5811:
5794:
5771:
5769:
5760:
5751:
5745:
5744:
5741:
5740:
5738:
5737:
5729:
5721:
5712:
5710:
5706:
5705:
5703:
5702:
5694:
5686:
5678:
5670:
5662:
5654:
5646:
5638:
5630:
5622:
5614:
5606:
5598:
5589:
5587:
5583:
5582:
5580:
5579:
5571:
5563:
5555:
5547:
5539:
5531:
5523:
5515:
5507:
5498:
5496:
5489:
5483:
5482:
5479:
5478:
5476:
5475:
5470:
5465:
5464:
5463:
5455:
5454:
5453:
5444:
5442:
5438:
5437:
5435:
5434:
5429:
5424:
5419:
5414:
5409:
5408:
5407:
5402:
5391:
5389:
5383:
5382:
5380:
5379:
5374:
5369:
5364:
5359:
5354:
5349:
5344:
5339:
5334:
5329:
5319:
5317:
5308:
5296:
5295:
5290:
5288:
5287:
5280:
5273:
5265:
5256:
5255:
5253:
5252:
5247:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5066:
5064:
5060:
5059:
5057:
5056:
5051:
5046:
5041:
5036:
5031:
5026:
5021:
5016:
5011:
5006:
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
4860:
4858:
4854:
4853:
4851:
4850:
4845:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4790:
4789:
4784:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4714:
4709:
4703:
4694:
4689:
4688:
4687:
4682:
4672:
4667:
4666:
4665:
4660:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4609:
4607:
4603:
4602:
4600:
4599:
4594:
4589:
4584:
4579:
4574:
4569:
4564:
4559:
4554:
4549:
4544:
4539:
4534:
4529:
4524:
4519:
4514:
4513:
4512:
4507:
4497:
4492:
4487:
4482:
4481:
4480:
4475:
4470:
4460:
4455:
4450:
4445:
4440:
4439:
4438:
4433:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4392:
4391:
4386:
4376:
4370:
4365:
4360:
4355:
4346:
4341:
4340:
4339:
4334:
4329:
4319:
4314:
4309:
4304:
4299:
4293:
4291:
4287:
4286:
4284:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4243:
4238:
4233:
4228:
4223:
4218:
4213:
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4158:
4157:
4156:
4151:
4141:
4140:
4139:
4134:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4063:
4062:
4057:
4047:
4042:
4037:
4032:
4027:
4022:
4016:
4014:
4010:
4009:
4007:
4006:
4001:
3996:
3991:
3986:
3981:
3976:
3971:
3966:
3957:
3952:
3947:
3942:
3937:
3932:
3931:
3930:
3925:
3920:
3915:
3910:
3905:
3895:
3890:
3885:
3880:
3875:
3870:
3869:
3868:
3863:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3812:
3811:
3806:
3801:
3796:
3791:
3786:
3776:
3775:
3774:
3769:
3764:
3754:
3749:
3748:
3747:
3742:
3737:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3676:
3674:
3670:
3669:
3667:
3666:
3661:
3660:
3659:
3654:
3649:
3644:
3639:
3634:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3593:
3592:
3587:
3582:
3577:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3521:
3520:
3515:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3434:
3433:
3428:
3418:
3413:
3408:
3403:
3402:
3401:
3396:
3391:
3386:
3376:
3371:
3366:
3365:
3364:
3354:
3349:
3344:
3339:
3334:
3333:
3332:
3327:
3322:
3312:
3307:
3306:
3305:
3300:
3295:
3290:
3285:
3274:
3272:
3268:
3267:
3253:
3251:
3250:
3243:
3236:
3228:
3209:
3208:
3196:
3195:External links
3193:
3191:
3190:
3146:
3118:(2): 192–199.
3103:
3068:
3024:
2980:
2926:
2891:
2863:(3): 297–302.
2848:
2830:(2): 395–400.
2819:
2784:
2749:
2714:
2671:
2625:
2603:10.1086/301601
2597:(5): 1117–22.
2582:
2553:
2530:10.1186/ar2165
2506:
2469:
2432:
2422:(3): 293–300.
2411:
2376:
2346:
2344:
2341:
2339:
2338:
2289:
2243:
2197:
2168:(3): 297–302.
2141:
2091:
2050:
2001:
1949:
1906:
1871:Genes to Cells
1857:
1802:
1791:(5): 237–256.
1770:
1757:10.1101/556761
1741:
1706:
1677:(6): 715–724.
1657:
1636:(3): 345–357.
1616:
1561:
1534:(1): 103–106.
1518:
1500:
1482:
1461:
1439:
1437:
1434:
1433:
1432:
1427:
1422:
1415:
1412:
1411:
1410:
1404:
1398:
1392:
1386:
1371:
1368:
1357:
1354:
1348:
1345:
1343:
1340:
1334:
1331:
1325:
1322:
1313:
1310:
1308:
1305:
1280:
1277:
1202:
1201:
1198:
1197:
1192:
1182:
1181:
1175:
1174:
1171:
1170:
1168:
1166:
1159:
1158:
1151:
1144:
1140:
1139:
1136:
1135:
1125:
1124:
1118:
1115:
1114:
1088:
1087:
1081:
1077:
1076:
1073:
1072:
1062:
1061:
1055:
1052:
1051:
1025:
1024:
1018:
1014:
1013:
1010:
1009:
1001:
1000:
994:
991:
990:
982:
981:
975:
969:
968:
965:
964:
956:
955:
949:
946:
945:
937:
936:
930:
924:
923:
920:
919:
911:
910:
904:
901:
900:
892:
891:
885:
879:
878:
873:
868:
864:
863:
853:
852:
849:
848:
837:
836:
834:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
692:
690:
686:
685:
683:
682:
677:
672:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
571:
570:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
450:
446:
442:
441:jejunal mucosa
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
83:
82:
74:
73:
62:
56:
55:
47:
46:
38:
37:
15:
13:
10:
9:
6:
4:
3:
2:
7390:
7389:
7378:
7375:
7373:
7370:
7368:
7365:
7364:
7362:
7343:
7340:
7338:
7335:
7333:
7330:
7328:
7325:
7323:
7320:
7318:
7315:
7312:
7311:
7308:
7305:
7303:
7300:
7298:
7295:
7293:
7290:
7288:
7285:
7282:
7281:
7279:
7275:
7265:
7262:
7261:
7259:
7257:
7253:
7247:
7244:
7242:
7239:
7237:
7234:
7232:
7229:
7227:
7224:
7222:
7219:
7217:
7214:
7212:
7209:
7207:
7204:
7203:
7201:
7199:
7195:
7189:
7186:
7184:
7181:
7179:
7176:
7174:
7171:
7169:
7166:
7164:
7161:
7159:
7156:
7154:
7151:
7149:
7146:
7144:
7141:
7139:
7136:
7134:
7131:
7129:
7126:
7124:
7121:
7119:
7116:
7115:
7113:
7111:
7107:
7101:
7098:
7096:
7093:
7091:
7088:
7086:
7083:
7081:
7078:
7076:
7073:
7071:
7068:
7066:
7063:
7061:
7058:
7056:
7053:
7052:
7050:
7048:
7044:
7041:
7037:
7031:
7027:
7024:
7020:
7013:
7009:
7008:
7006:
7004:
7000:
6993:
6989:
6988:
6986:
6984:
6980:
6973:
6969:
6968:
6966:
6964:
6960:
6949:
6945:
6944:
6942:
6940:
6936:
6930:
6927:
6925:
6922:
6919:
6918:
6915:
6912:
6910:
6907:
6904:
6903:
6901:
6899:
6898:IFNGR (γ, II)
6895:
6889:
6886:
6883:
6882:
6879:
6876:
6874:
6871:
6869:
6866:
6864:
6861:
6859:
6856:
6853:
6852:
6849:
6846:
6844:
6841:
6839:
6836:
6834:
6831:
6829:
6826:
6824:
6821:
6818:
6814:
6810:
6807:
6805:
6802:
6800:
6797:
6795:
6792:
6790:
6787:
6785:
6782:
6779:
6775:
6771:
6767:
6763:
6759:
6755:
6751:
6747:
6743:
6739:
6735:
6731:
6727:
6724:
6722:
6719:
6717:
6716:Albinterferon
6714:
6711:
6710:
6708:
6706:
6702:
6699:
6697:
6693:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6657:
6656:
6654:
6652:
6648:
6641:
6637:
6636:
6634:
6632:
6628:
6622:
6619:
6616:
6615:
6612:
6609:
6607:
6604:
6602:
6599:
6597:
6594:
6592:
6589:
6586:
6585:
6583:
6581:
6577:
6571:
6568:
6566:
6563:
6561:
6558:
6555:
6554:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6520:
6519:
6517:
6515:
6514:GM-CSF (CSF2)
6511:
6505:
6502:
6500:
6499:Pegfilgrastim
6497:
6495:
6492:
6490:
6487:
6485:
6482:
6480:
6477:
6475:
6472:
6470:
6467:
6464:
6463:
6461:
6459:
6455:
6449:
6446:
6444:
6441:
6439:
6436:
6434:
6431:
6429:
6426:
6424:
6421:
6419:
6418:Epoetin theta
6416:
6414:
6413:Epoetin omega
6411:
6409:
6408:Epoetin kappa
6406:
6404:
6403:Epoetin gamma
6401:
6399:
6396:
6394:
6393:Epoetin delta
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6364:
6361:
6359:
6356:
6353:
6352:
6350:
6348:
6344:
6341:
6339:
6335:
6328:
6324:
6323:
6321:
6319:
6315:
6311:
6308:
6301:
6296:
6294:
6289:
6287:
6282:
6281:
6278:
6264:
6261:
6259:
6256:
6254:
6251:
6250:
6249:
6245:
6242:
6238:
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3608:
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3526:
3523:
3519:
3516:
3514:
3511:
3510:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
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3454:
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3449:
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3444:
3441:
3439:
3436:
3432:
3429:
3427:
3424:
3423:
3422:
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3381:
3380:
3377:
3375:
3372:
3370:
3367:
3363:
3360:
3359:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3331:
3328:
3326:
3323:
3321:
3318:
3317:
3316:
3313:
3311:
3308:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3280:
3279:
3276:
3275:
3273:
3269:
3264:
3260:
3256:
3249:
3244:
3242:
3237:
3235:
3230:
3229:
3226:
3222:
3221:
3219:
3218:public domain
3215:
3206:
3202:
3199:
3198:
3194:
3187:
3183:
3178:
3173:
3169:
3165:
3161:
3157:
3153:
3147:
3143:
3139:
3135:
3131:
3126:
3121:
3117:
3113:
3109:
3104:
3100:
3096:
3091:
3086:
3083:(6): 1041–9.
3082:
3078:
3074:
3069:
3065:
3061:
3057:
3053:
3049:
3048:10.1038/71667
3045:
3041:
3037:
3030:
3025:
3021:
3017:
3012:
3007:
3003:
2999:
2995:
2991:
2987:
2981:
2977:
2973:
2968:
2963:
2958:
2953:
2949:
2945:
2942:(7): 3540–5.
2941:
2937:
2933:
2927:
2923:
2919:
2914:
2909:
2905:
2901:
2900:J. Biol. Chem
2897:
2892:
2888:
2884:
2880:
2876:
2871:
2866:
2862:
2858:
2854:
2849:
2845:
2841:
2837:
2833:
2829:
2825:
2820:
2816:
2812:
2807:
2802:
2798:
2794:
2793:J. Biol. Chem
2790:
2785:
2781:
2777:
2772:
2767:
2763:
2759:
2758:J. Biol. Chem
2755:
2750:
2746:
2742:
2737:
2732:
2728:
2724:
2723:J. Biol. Chem
2720:
2715:
2711:
2707:
2703:
2699:
2694:
2689:
2685:
2681:
2677:
2672:
2668:
2664:
2660:
2656:
2652:
2651:10.1038/36593
2648:
2644:
2640:
2636:
2632:
2626:
2622:
2618:
2613:
2608:
2604:
2600:
2596:
2592:
2588:
2583:
2579:
2575:
2571:
2567:
2564:(2): 359–61.
2563:
2559:
2554:
2550:
2546:
2541:
2536:
2531:
2526:
2522:
2518:
2517:
2512:
2507:
2503:
2499:
2495:
2491:
2487:
2483:
2480:(2): 221–32.
2479:
2475:
2470:
2466:
2462:
2458:
2454:
2450:
2446:
2443:(2): 226–32.
2442:
2438:
2433:
2429:
2425:
2421:
2417:
2412:
2408:
2404:
2399:
2394:
2390:
2386:
2382:
2377:
2373:
2369:
2365:
2361:
2357:
2353:
2348:
2347:
2342:
2334:
2330:
2325:
2320:
2316:
2312:
2308:
2304:
2300:
2293:
2290:
2285:
2281:
2276:
2271:
2267:
2263:
2262:J. Biol. Chem
2259:
2252:
2250:
2248:
2244:
2239:
2235:
2230:
2225:
2221:
2217:
2216:J. Biol. Chem
2213:
2206:
2204:
2202:
2198:
2193:
2189:
2185:
2181:
2176:
2171:
2167:
2163:
2159:
2152:
2150:
2148:
2146:
2142:
2137:
2133:
2128:
2123:
2119:
2115:
2114:J. Biol. Chem
2111:
2104:
2102:
2100:
2098:
2096:
2092:
2087:
2083:
2078:
2073:
2069:
2065:
2061:
2054:
2051:
2046:
2042:
2038:
2034:
2029:
2024:
2020:
2016:
2012:
2005:
2002:
1997:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1965:
1961:
1953:
1950:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1910:
1907:
1902:
1898:
1894:
1890:
1885:
1880:
1877:(6): 353–62.
1876:
1872:
1868:
1861:
1858:
1853:
1849:
1845:
1841:
1836:
1831:
1827:
1823:
1816:
1809:
1807:
1803:
1798:
1794:
1790:
1786:
1779:
1777:
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1771:
1768:
1764:
1758:
1753:
1745:
1742:
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1733:
1729:
1725:
1721:
1717:
1710:
1707:
1702:
1698:
1694:
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1685:
1680:
1676:
1672:
1668:
1661:
1658:
1653:
1649:
1644:
1639:
1635:
1631:
1627:
1620:
1617:
1612:
1608:
1604:
1600:
1596:
1595:10.1038/36593
1592:
1588:
1584:
1580:
1576:
1568:
1566:
1562:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1522:
1519:
1514:
1510:
1504:
1501:
1496:
1492:
1486:
1483:
1479:
1475:
1470:
1468:
1466:
1462:
1458:
1454:
1449:
1447:
1445:
1441:
1435:
1431:
1428:
1426:
1423:
1421:
1418:
1417:
1413:
1408:
1405:
1402:
1399:
1396:
1393:
1390:
1387:
1384:
1381:
1380:
1379:
1377:
1369:
1367:
1364:
1355:
1353:
1346:
1341:
1339:
1332:
1330:
1323:
1321:
1318:
1311:
1306:
1304:
1300:
1296:
1294:
1290:
1286:
1278:
1276:
1274:
1270:
1266:
1262:
1261:stromal cells
1257:
1255:
1250:
1248:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1216:
1212:
1208:
1196:
1191:
1187:
1183:
1180:
1176:
1169:
1167:
1164:
1160:
1156:
1152:
1149:
1145:
1141:
1134:
1132:
1126:
1122:
1119:
1113:
1111:
1107:
1103:
1099:
1095:
1089:
1085:
1082:
1078:
1071:
1069:
1063:
1059:
1056:
1050:
1048:
1044:
1040:
1036:
1032:
1026:
1022:
1019:
1017:RefSeq (mRNA)
1015:
1008:
1007:
1002:
998:
995:
989:
988:
983:
979:
976:
974:
970:
963:
962:
957:
953:
950:
944:
943:
938:
934:
931:
929:
925:
918:
917:
912:
908:
905:
899:
898:
893:
889:
886:
884:
880:
877:
874:
872:
869:
865:
862:
858:
854:
847:
843:
838:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
693:
691:
688:
687:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
460:
456:
452:
448:
444:
440:
436:
433:parotid gland
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
345:1|1 E2.1
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
84:
79:
76:
75:
71:
68:
61:
57:
52:
48:
44:
39:
34:
29:
22:
7322:Lestaurtinib
7313:
7283:
7221:Ritlecitinib
7153:Lestaurtinib
7100:Upadacitinib
6929:Fontolizumab
6920:
6905:
6884:
6873:Rontalizumab
6854:
6712:
6667:Pegacaristim
6658:
6617:
6587:
6580:M-CSF (CSF1)
6560:Mavrilimumab
6556:
6550:Sargramostim
6540:Molgramostim
6525:Ecogramostim
6521:
6494:Nartograstim
6465:
6458:G-CSF (CSF3)
6443:Peginesatide
6423:Epoetin zeta
6388:Epoetin beta
6383:Epoetin alfa
6354:
6174:IL 17 family
5734:
5726:
5718:
5699:
5691:
5683:
5675:
5667:
5659:
5651:
5643:
5635:
5627:
5624:
5619:
5611:
5603:
5595:
5576:
5568:
5560:
5552:
5544:
5542:Fas receptor
5536:
5528:
5520:
5512:
5504:
5487:TNF receptor
4913:
4776:
4696:
4674:
4652:
4499:
4462:
4425:
4378:
4348:
4321:
4143:
4049:
3897:
3626:
3378:
3211:
3210:
3201:RANK+Protein
3162:(1): 64–76.
3159:
3155:
3115:
3111:
3080:
3076:
3039:
3035:
2993:
2989:
2939:
2935:
2903:
2899:
2860:
2856:
2827:
2823:
2796:
2792:
2761:
2757:
2726:
2722:
2686:(6): 911–7.
2683:
2679:
2634:
2630:
2594:
2590:
2561:
2557:
2520:
2514:
2477:
2473:
2440:
2436:
2419:
2415:
2388:
2384:
2358:(2): 340–6.
2355:
2351:
2306:
2302:
2292:
2265:
2261:
2219:
2215:
2165:
2161:
2117:
2113:
2067:
2063:
2053:
2021:(1): 41–50.
2018:
2014:
2004:
1963:
1959:
1952:
1919:
1915:
1909:
1874:
1870:
1860:
1825:
1821:
1788:
1785:IBMS BoneKEy
1784:
1744:
1719:
1715:
1709:
1674:
1670:
1660:
1633:
1629:
1619:
1578:
1574:
1531:
1527:
1521:
1512:
1503:
1494:
1485:
1373:
1370:Interactions
1359:
1350:
1336:
1327:
1315:
1301:
1297:
1282:
1258:
1251:
1218:
1214:
1210:
1206:
1205:
1128:
1106:NP_001265197
1102:NP_001257880
1098:NP_001257879
1094:NP_001257878
1091:
1065:
1043:NM_001278268
1039:NM_001270951
1035:NM_001270950
1031:NM_001270949
1028:
1004:
985:
959:
940:
914:
895:
875:
870:
716:ossification
665:cell surface
519:right kidney
407:
400:
366:105,775,709
353:105,708,443
127:External IDs
86:
7332:Quizartinib
7327:Midostaurin
7216:Peficitinib
7178:Ruxolitinib
7173:Peficitinib
7128:Baricitinib
7090:Ruxolitinib
7085:Peficitinib
7080:Oclacitinib
7075:Momelotinib
7060:Baricitinib
7055:Abrocitinib
6963:Interleukin
6921:Antibodies:
6878:Sifalimumab
6863:Faralimomab
6858:Anifrolumab
6855:Antibodies:
6677:Romiplostim
6662:Eltrombopag
6631:SCF (c-Kit)
6557:Antibodies:
6545:Regramostim
6479:Lenograstim
5660:(TNFRSF13C)
5652:(TNFRSF13B)
5644:(TNFRSF12A)
5636:(TNFRSF11B)
5628:(TNFRSF11A)
5620:(TNFRSF10D)
5612:(TNFRSF10C)
5604:(TNFRSF10B)
5596:(TNFRSF10A)
3042:(1): 45–8.
1722:: 795–823.
1630:Endocr. Rev
1265:osteoblasts
523:Paneth cell
465:gallbladder
265:62,391,288
252:62,325,287
105:Identifiers
7361:Categories
7317:Emfilermin
7168:Pacritinib
7070:Filgotinib
7036:inhibitors
6924:Emapalumab
6696:Interferon
6621:Agerafenib
6611:Mirimostim
6601:Lanimostim
6535:Milodistim
6484:Leridistim
6469:Filgrastim
6310:modulators
5735:(TNFRSF27)
5727:(TNFRSF25)
5719:(TNFRSF21)
5700:(TNFRSF19)
5692:(TNFRSF18)
5684:(TNFRSF17)
5676:(TNFRSF16)
5668:(TNFRSF14)
5553:(TNFRSF6B)
5513:(TNFRSF1B)
5505:(TNFRSF1A)
3261:(see also
3036:Nat. Genet
1480:, May 2017
1459:, May 2017
1436:References
1254:osteoclast
1231:osteoclast
495:left colon
411:(ortholog)
148:HomoloGene
7342:Sunitinib
7337:Sorafenib
7246:ZM-449829
7236:WHI-P 154
7226:TCS-21311
7163:NSC-33994
7118:Atiprimod
6906:Agonists:
6888:Bifarcept
6713:Agonists:
6659:Agonists:
6591:Cilmostim
6588:Agonists:
6565:Namilumab
6522:Agonists:
6466:Agonists:
6355:Agonists:
6318:Chemokine
6019:prolactin
5577:(TNFRSF9)
5569:(TNFRSF8)
5561:(TNFRSF7)
5545:(TNFRSF6)
5537:(TNFRSF5)
5529:(TNFRSF4)
5521:(TNFRSF3)
3077:Mol. Cell
2990:Genes Dev
2857:FEBS Lett
2385:Circ. Res
2162:FEBS Lett
1363:denosumab
1279:Structure
1219:TNFRSF11A
1131:NP_033425
1110:NP_003830
1068:NM_009399
1047:NM_003839
861:Orthologs
160:TNFRSF11A
156:GeneCards
119:TNFRSF11A
36:TNFRSF11A
7241:ZM-39923
7158:NSC-7908
7123:AZD-1480
7014:instead.
6994:instead.
6974:instead.
6950:instead.
6868:MEDI-545
6642:instead.
6570:Otilimab
6373:CNTO-530
6329:instead.
6248:TGF-beta
5749:JAK-STAT
5697:TAJ/TROY
3255:Proteins
3186:18606301
3142:36852811
3134:11811549
3099:10635328
3064:32165581
3056:10615125
3020:10500098
2976:10097072
2922:10075662
2887:46210019
2879:10025951
2710:20552512
2549:17634140
2502:12283459
2494:17288531
2465:33543150
2457:16240334
2428:15615497
2407:15564564
2372:11856640
2333:11809792
2284:10075662
2192:46210019
2184:10025951
2086:14679212
2045:15438954
2037:11051546
1988:19940926
1944:22506007
1936:11485016
1893:10421844
1844:20483727
1767:91203744
1736:11861618
1701:17303204
1693:10380891
1652:10368775
1556:10628044
1548:14523602
1476:–
1455:–
1414:See also
1376:interact
1307:Function
1289:cysteine
1179:Wikidata
840:Sources:
655:membrane
499:duodenum
449:duodenum
244:18q21.33
7183:SD-1008
6358:ARA-290
6244:Ser/Thr
6066:IL22RA2
6062:IL22RA1
6033:Type II
5962:IL12RB2
5958:IL12RB1
5941:IL12RB1
5840:β-chain
5809:IL13RA2
5805:IL13RA1
5767:γ-chain
5063:301–350
4857:251–300
4809:CD240CE
4606:201–250
4290:151–200
4013:101–150
3177:2443850
2944:Bibcode
2844:9878548
2815:9852070
2780:9774460
2745:9685412
2702:9626621
2667:4373990
2659:9367155
2639:Bibcode
2621:9345096
2612:1716035
2578:7911698
2540:1924516
2238:9685412
2136:9852070
1996:4403682
1968:Bibcode
1901:6348480
1852:6913229
1752:bioRxiv
1611:4373990
1603:9367155
1583:Bibcode
1478:Ensembl
1457:Ensembl
1269:T cells
973:UniProt
928:Ensembl
867:Species
846:QuickGO
675:cytosol
515:jejunum
386:pattern
144:1314891
112:Aliases
7277:Others
7143:CYT387
7133:CHZ868
7022:Others
6778:IFNA21
6774:IFNA17
6770:IFNA16
6766:IFNA14
6762:IFNA13
6758:IFNA10
6263:family
6258:TGFBR2
6253:TGFBR1
6207:IL17RE
6202:IL17RD
6197:IL17RC
6192:IL17RB
6187:IL17RA
6164:IL18R1
6117:IFNGR2
6113:IFNGR1
6104:IFNAR2
6100:IFNAR1
6079:IL20RB
6075:IL20RA
6054:IL10RB
6050:IL10RA
5984:other
5914:IL27RA
5905:IL11RA
5873:GM-CSF
5758:Type I
5641:TweakR
5473:CMKLR1
5451:CX3CR1
5070:CD300A
5029:CDw293
4814:CD240D
4675:CD213a
4653:CDw210
4618:CD202b
4592:CDw199
4587:CDw198
4241:CD140b
3673:51–100
3207:(MeSH)
3184:
3174:
3140:
3132:
3097:
3062:
3054:
3018:
3011:317030
3008:
2974:
2964:
2920:
2885:
2877:
2842:
2813:
2778:
2743:
2708:
2700:
2665:
2657:
2631:Nature
2619:
2609:
2576:
2547:
2537:
2500:
2492:
2463:
2455:
2426:
2405:
2370:
2331:
2324:134634
2321:
2282:
2236:
2190:
2182:
2134:
2084:
2043:
2035:
1994:
1986:
1960:Nature
1942:
1934:
1899:
1891:
1850:
1842:
1765:
1754:
1734:
1699:
1691:
1650:
1609:
1601:
1575:Nature
1554:
1546:
1403:, and
1378:with:
1347:Cancer
1267:, and
1165:search
1163:PubMed
1006:O35305
987:Q9Y6Q6
883:Entrez
557:BioGPS
531:embryo
445:rectum
136:603499
6817:IFNB3
6813:IFNB1
6754:IFNA8
6750:IFNA7
6746:IFNA6
6742:IFNA5
6738:IFNA4
6734:IFNA2
6730:IFNA1
6232:CSF1R
6160:IL18R
6153:IL1R2
6148:IL1R1
6084:IL28R
6071:IL20R
6058:IL22R
6046:IL10R
5996:G-CSF
5978:Other
5967:IL23R
5954:IL12R
5931:CNTFR
5896:IL6RA
5883:gp130
5866:IL5RA
5857:IL3RA
5828:IL21R
5818:IL7RA
5801:IL13R
5792:IL15R
5788:IL2RB
5784:IL2RA
5732:EDA2R
5709:21-27
5657:BAFFR
5586:11-20
5574:CD137
5526:CD134
5510:TNFR2
5502:TNFR1
5468:CCBP2
5447:CX3C
5441:Other
5432:CXCR7
5427:CXCR6
5422:CXCR5
5417:CXCR4
5412:CXCR3
5405:CXCR2
5400:CXCR1
5377:CCR10
5337:CCRL2
5327:CCRL1
5305:GPCRs
5250:CD350
5245:CD349
5240:CD344
5235:CD340
5230:CD339
5225:CD338
5220:CD337
5215:CD336
5210:CD335
5205:CD334
5200:CD333
5195:CD332
5190:CD331
5185:CD329
5180:CD328
5175:CD327
5170:CD326
5165:CD325
5160:CD324
5155:CD322
5150:CD321
5145:CD320
5140:CD318
5135:CD317
5130:CD316
5125:CD315
5120:CD314
5115:CD312
5110:CD309
5105:CD307
5100:CD306
5095:CD305
5090:CD304
5085:CD303
5080:CD302
5075:CD301
5054:CD299
5049:CD298
5044:CD297
5039:CD295
5034:CD294
5024:CD292
5019:CD290
5014:CD289
5009:CD288
5004:CD286
4999:CD284
4994:CD283
4989:CD282
4984:CD281
4979:CD280
4974:CD279
4969:CD278
4964:CD276
4959:CD275
4954:CD274
4949:CD273
4944:CD272
4939:CD271
4934:CD269
4929:CD268
4924:CD267
4919:CD266
4914:CD265
4909:CD264
4904:CD263
4899:CD262
4894:CD261
4889:CD258
4884:CD257
4879:CD256
4874:CD254
4869:CD253
4864:CD252
4848:CD249
4843:CD248
4839:CD247
4834:CD246
4829:CD244
4824:CD243
4819:CD241
4804:CD239
4799:CD238
4794:CD236
4777:CD235
4772:CD234
4767:CD233
4762:CD230
4757:CD229
4752:CD228
4747:CD227
4742:CD226
4737:CD225
4732:CD224
4727:CD223
4722:CD222
4717:CD221
4712:CD220
4697:CD218
4692:CD217
4670:CD212
4648:CD209
4643:CD208
4638:CD207
4633:CD206
4628:CD205
4623:CD204
4613:CD201
4597:CD200
4582:CD197
4577:CD196
4572:CD195
4567:CD194
4562:CD193
4557:CD192
4552:CD191
4547:CD186
4542:CD185
4537:CD184
4532:CD183
4527:CD182
4522:CD181
4517:CD180
4500:CD179
4495:CD178
4490:CD177
4485:CD174
4463:CD172
4458:CD171
4453:CD170
4448:CD169
4443:CD168
4426:CD167
4421:CD166
4416:CD164
4411:CD163
4406:CD162
4401:CD161
4396:CD160
4379:CD159
4349:CD158
4344:CD157
4322:CD156
4317:CD155
4312:CD154
4307:CD153
4302:CD152
4297:CD151
4281:CD150
4276:CD148
4271:CD147
4266:CD146
4261:CD144
4256:CD143
4251:CD142
4246:CD141
4236:CD138
4231:CD137
4226:CD136
4221:CD135
4216:CD134
4211:CD133
4206:CD132
4201:CD131
4196:CD130
4191:CD129
4186:CD127
4181:CD126
4176:CD125
4171:CD124
4166:CD123
4161:CD122
4144:CD121
4127:CD120
4122:CD119
4117:CD118
4112:CD117
4107:CD116
4102:CD115
4097:CD114
4092:CD113
4087:CD112
4082:CD111
4077:CD110
4072:CD109
4067:CD108
4050:CD107
4045:CD106
4040:CD105
4035:CD104
4030:CD103
4025:CD102
4020:CD101
4004:CD100
3138:S2CID
3060:S2CID
3032:(PDF)
2967:22329
2883:S2CID
2706:S2CID
2663:S2CID
2498:S2CID
2461:S2CID
2188:S2CID
2041:S2CID
1992:S2CID
1940:S2CID
1897:S2CID
1848:S2CID
1818:(PDF)
1763:S2CID
1697:S2CID
1607:S2CID
1552:S2CID
1420:RANKL
1407:TRAF6
1401:TRAF5
1395:TRAF3
1389:TRAF2
1383:TRAF1
1317:TRAF6
1243:NF-κB
1239:TRAFs
1227:RANKL
916:21934
876:Mouse
871:Human
842:Amigo
507:ileum
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
21:RANKL
7256:TYK2
7198:JAK3
7110:JAK2
7047:JAK1
7012:here
7010:See
6992:here
6990:See
6983:TGFβ
6972:here
6970:See
6948:here
6640:here
6638:See
6327:here
6325:See
6182:IL17
6096:-α/β
5926:LIFR
5921:OSMR
5862:IL5R
5853:IL3R
5823:IL9R
5814:IL7R
5797:IL4R
5780:IL2R
5689:GITR
5681:BCMA
5673:NGFR
5665:HVEM
5649:TACI
5625:RANK
5617:DcR2
5609:DcR1
5566:CD30
5558:CD27
5550:DcR3
5534:CD40
5518:LTBR
5495:1-10
5461:XCR1
5395:IL-8
5372:CCR9
5367:CCR8
5362:CCR7
5357:CCR6
5352:CCR5
5347:CCR4
5342:CCR3
5332:CCR2
5323:CCR1
3999:CD99
3994:CD98
3989:CD97
3984:CD96
3979:CD95
3974:CD94
3969:CD93
3964:CD92
3960:CD91
3955:CD90
3950:CD89
3945:CD88
3940:CD87
3935:CD86
3898:CD85
3893:CD84
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