365:
2796:
342:
2991:
239:
264:
2901:
2781:
2766:
3006:
2871:
2856:
2841:
2826:
2811:
1295:
2886:
40:
616:
3021:
371:
270:
2976:
2961:
2946:
2931:
2916:
2751:
1384:
gene from its mother, but not from its father. The physiologic basis lies in pregnancy whereby the mutated gene product, retinol binding protein (RBP), has negative effects in transferring vitamin A from maternal liver storage sites to the placenta, and then again on the fetal circulation side when
1389:
gene is inherited from the father. The above mechanism is separate from previously known types of maternal inheritance effects such as genomic imprinting, mitochondrial inheritance, or maternal oocyte mRNA transfer. The authors of the above study cite the potential of vitamin A supplementation in
1394:
mutation with retinyl ester which utilizes an RBP-independent pathway to deliver retinoids from the maternal intestines directly to the placenta and ultimately is uptaken by the fetus. The key would be to supplement during the first several months of life when the eye begins to develop, as
66:
1321:
Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. Animal studies using RBP4-antagonists showed that lowering RBP4 can lead to reduction in the accumulation of
2795:
1379:
gene have recently been linked to a form of autosomal dominant microphthalmia, anophthalmia, and coloboma (MAC) disease. A unique feature of this disease is the maternal inheritance effect, when a fetus inherits a mutated copy of the
2990:
1615:
Cioffi CL, Dobri N, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Golden KC, Zhu L, Kitchen DB, Barnes KD, Racz B, Qin Q, Michelotti E, Cywin CL, Martin WH, Pearson PG, Johnson G, Petrukhin K (September 2014).
2036:
Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS (December 2003). "Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models".
2900:
1790:
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB (July 2005). "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes".
2648:
Seeliger MW, Biesalski HK, Wissinger B, Gollnick H, Gielen S, Frank J, Beck S, Zrenner E (January 1999). "Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis".
2780:
2765:
2340:
Kameko M, Ichikawa M, Katsuyama T, Kanai M, Kato M, Akamatsu T (April 1986). "Immunohistochemical localization of plasma retinol-binding protein and prealbumin in human pancreatic islets".
1714:
Naylor HM, Newcomer ME (March 1999). "The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP".
1341:
proved that reduction in serum RBP4 level could inhibit lipofuscin without inhibiting the visual cycle. One clinical study in age-related macular degeneration (AMD) was conducted using
1302:
RBP4 is a single polypeptide chain with a hydrophobic pocket where retinol binds. The RBP4-retinol complex then binds transthyretin in circulation to prevent renal filtration of RBP4.
1618:"Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease"
3005:
2870:
2855:
2840:
2825:
2810:
1368:
in a smaller portion and acts as a signal to surrounding cells, when there is a decrease in plasma glucose concentration. It is suspected that an elevated level of RBP4 attracts
2885:
2202:
Monaco HL, Zanotti G (April 1992). "Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity".
1345:. The study showed trends in reducing lesion growth rate in AMD and rate of conversion from early stage AMD (dry AMD) to late stage AMD (wet AMD) without serious side effects.
378:
277:
1262:. RBP4 has been a drug target for ophthalmology research due to its role in vision. RBP4 may also be involved in metabolic diseases as suggested by recent studies.
2804:: THE INTERACTION OF N-ETHYL RETINAMIDE WITH PLASMA RETINOL-BINDING PROTEIN (RBP) AND THE CRYSTAL STRUCTURE OF THE RETINOID-RBP COMPLEX AT 1.9 ANGSTROMS RESOLUTION
2278:"Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals"
3367:
1385:
delivering vitamin A from the placenta to developing fetal tissues, most notably the developing eye. This 'double whammy' effect does not exist when the mutant
1286:. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
3352:
3150:
3061:
1751:"Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases"
2533:
Rask L, Anundi H, Böhme J, Eriksson U, Ronne H, Sege K, Peterson PA (February 1981). "Structural and functional studies of vitamin A-binding proteins".
949:
930:
200:
2319:
Pfeffer BA, Clark VM, Flannery JG, Bok D (July 1986). "Membrane receptors for retinol-binding protein in cultured human retinal pigment epithelium".
1278:(vitamin A) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with
1552:
Rocchi M, Covone A, Romeo G, Faraonio R, Colantuoni V (March 1989). "Regional mapping of RBP4 to 10q23----q24 and RBP1 to 3q21----q22 in man".
2580:"Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure"
3464:
3454:
3100:
3020:
2730:
1493:
2999:: The structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of RBP
1475:
364:
3357:
2975:
2960:
2945:
2930:
2915:
2169:"Interaction between prealbumin and retinol-binding protein studied by affinity chromatography, gel filtration and two-phase partition"
3398:
2750:
1173:
1180:
341:
3403:
2615:"The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein"
1598:
1309:(two molecules of TTR combine with two molecules of RBP4 to form a complex with a total molecular weight of approximately 80,000
1298:
Two molecules of RBP4 (in yellow and red) bound to retinol (in orange) complexed with four molecules of TTR (in purple and blue)
3418:
2239:
Cowan SW, Newcomer ME, Jones TA (1990). "Crystallographic refinement of human serum retinol binding protein at 2A resolution".
1462:
1441:
2095:
Fex G, Hansson B (February 1979). "Retinol-binding protein from human urine and its interaction with retinol and prealbumin".
3145:
3054:
263:
238:
1458:
63:
2909:: Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution
2066:
Newcomer ME, Ong DE (October 2000). "Plasma retinol binding protein: structure and function of the prototypic lipocalin".
1437:
3215:
180:
3260:
1985:"Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease"
2414:"Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content"
377:
276:
3428:
3229:
3082:
3047:
2723:
1893:"RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance"
1254:
in humans. It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a
370:
269:
3219:
2681:
994:
188:
3433:
3307:
3255:
2789:: CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTION
2774:: CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTION
975:
3423:
3284:
252:
1749:
Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL (December 2005).
3393:
3289:
2716:
2542:
1800:
1331:
1983:
Chou CM, Nelson C, Tarlé SA, Pribila JT, Bardakjian T, Woods S, Schneider A, Glaser T (April 2015).
167:
3459:
3105:
1283:
1152:
1127:
1123:
1093:
1072:
1068:
3344:
2677:
2566:
2379:"Loss of retinol-binding properties for plasma retinol-binding protein in normal human epidermis"
2365:
2264:
2227:
2155:
1965:
1824:
1577:
1353:
212:
1247:(vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the
1156:
1131:
1097:
1064:
1844:"Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony"
39:
3014:: CRYSTALLOGRAPHIC REFINEMENT OF HUMAN SERUM RETINOL BINDING PROTEIN AT 2 ANGSTROMS RESOLUTION
2688:
2658:
2636:
2601:
2558:
2521:
2478:
2435:
2400:
2357:
2328:
2307:
2256:
2219:
2190:
2147:
2112:
2083:
2054:
2014:
1957:
1922:
1873:
1816:
1772:
1731:
1696:
1647:
1569:
1534:
1357:
1327:
160:
56:
2879:: CRYSTAL STRUCTURE OF LIGANDED AND UNLIGANDED FORMS OF BOVINE PLASMA RETINOL-BINDING PROTEIN
2864:: CRYSTAL STRUCTURE OF LIGANDED AND UNLIGANDED FORMS OF BOVINE PLASMA RETINOL-BINDING PROTEIN
2447:
Colantuoni V, Romano V, Bensi G, Santoro C, Costanzo F, Raugei G, Cortese R (November 1983).
3362:
2849:: CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN
2834:: CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN
2819:: CRYSTALLOGRAPHIC STUDIES ON COMPLEXES BETWEEN RETINOIDS AND PLASMA RETINOL-BINDING PROTEIN
2626:
2591:
2550:
2511:
2503:
2468:
2460:
2425:
2390:
2349:
2297:
2289:
2248:
2211:
2180:
2137:
2104:
2075:
2046:
2004:
1996:
1949:
1912:
1904:
1863:
1855:
1808:
1762:
1723:
1686:
1678:
1637:
1629:
1561:
1524:
615:
457:
388:
332:
287:
3211:
3136:
3074:
2894:: Crystal Structure of Recombinant Human Serum Retinol-Binding Protein at 1.7 A Resolution
2490:
Newcomer ME, Jones TA, Aqvist J, Sundelin J, Eriksson U, Rask L, Peterson PA (July 1984).
1294:
432:
208:
2546:
1940:
Galic S, Oakhill JS, Steinberg GR (March 2010). "Adipose tissue as an endocrine organ".
1804:
3334:
3202:
2554:
2507:
2449:"Cloning and sequencing of a full length cDNA coding for human retinol-binding protein"
2293:
2185:
2168:
2108:
2009:
1984:
1917:
1892:
1868:
1843:
1642:
1617:
1395:
supplementing later in pregnancy would be too late to avoid any potential MAC disease.
2631:
2614:
2596:
2579:
2516:
2491:
2473:
2448:
2430:
2413:
2302:
2277:
2079:
2050:
1691:
1666:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
728:
723:
718:
713:
708:
692:
687:
682:
677:
672:
667:
662:
657:
3448:
3408:
3272:
3234:
3197:
2697:
2142:
2125:
1414:
1338:
1310:
1306:
1279:
1259:
644:
2268:
2231:
1581:
3192:
2613:
Berni R, Malpeli G, Folli C, Murrell JR, Liepnieks JJ, Benson MD (September 1994).
2570:
2369:
2159:
1969:
1828:
450:
229:
192:
2395:
2378:
216:
3372:
3224:
3140:
2068:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
1498:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1480:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1342:
2000:
1908:
1372:
to the fat tissue, causes local inflammation, and leads to insulin resistance.
533:
1953:
1667:"Retinol-binding protein: the transport protein for vitamin A in human plasma"
1529:
1512:
1369:
1365:
1323:
1255:
349:
246:
196:
3039:
2464:
1360:
in the AG4KO mouse model. In addition to the liver, RBP4 is also secreted by
3413:
3377:
1891:
Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB (March 2014).
1409:
1361:
1349:
1271:
894:
593:
471:
416:
403:
315:
302:
204:
2252:
2087:
2058:
2018:
1961:
1926:
1877:
1820:
1776:
1735:
1651:
2662:
2640:
2605:
2562:
2525:
2482:
2439:
2404:
2361:
2332:
2311:
2260:
2223:
2215:
1700:
1573:
1538:
1220:
1215:
2194:
2151:
2116:
1767:
1750:
1513:"The complete amino acid sequence of human serum retinol-binding protein"
1204:
1039:
1020:
1812:
3070:
2702:
2692:
2353:
1565:
1404:
1275:
1244:
1240:
1006:
961:
1727:
1682:
1633:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
1859:
1188:
916:
2578:
Jaconi S, Rose K, Hughes GJ, Saurat JH, Siegenthaler G (June 1995).
17:
3120:
3115:
3110:
3095:
3090:
1335:
1293:
879:
875:
3322:
3317:
3312:
1251:
184:
3043:
2712:
624:
2708:
2687:
Overview of all the structural information available in the
2492:"The three-dimensional structure of retinol-binding protein"
2126:"The primary structure of the human retinol-binding protein"
1282:, which prevents its loss by filtration through the kidney
850:
negative regulation of cardiac muscle cell proliferation
440:
3029:: RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN
1599:"Entrez Gene: RBP4 retinol binding protein 4, plasma"
605:
2276:
D'Onofrio C, Colantuoni V, Cortese R (August 1985).
3386:
3343:
3300:
3243:
3129:
3081:
1145:
1116:
1086:
1057:
2412:Rask L, Vahlquist A, Peterson PA (November 1971).
2167:Fex G, Albertsson PA, Hansson B (September 1979).
1454:
1452:
1450:
1433:
1431:
1429:
1511:Rask L, Anundi H, Fohlman J, Peterson PA (1987).
840:embryonic retina morphogenesis in camera-type eye
387:
286:
2984:: Crystal structure of bovine holo-RBP at pH 7.0
2969:: Crystal structure of bovine holo-RBP at pH 9.0
2954:: Crystal structure of bovine holo-RBP at pH 4.0
2939:: Crystal structure of bovine holo-RBP at pH 3.0
2924:: Crystal structure of bovine holo-RBP at pH 2.0
2651:Investigative Ophthalmology & Visual Science
2321:Investigative Ophthalmology & Visual Science
1755:Investigative Ophthalmology & Visual Science
2759:: RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA
1326:that leads to vision loss in eye diseases like
1459:GRCm38: Ensembl release 89: ENSMUSG00000024990
3055:
2724:
2124:Rask L, Anundi H, Peterson PA (August 1979).
1665:Kanai M, Raz A, Goodman DS (September 1968).
171:, MCOPCB10, RDCCAS, retinol binding protein 4
8:
1438:GRCh38: Ensembl release 89: ENSG00000138207
1390:pregnant females who are known to carry an
3151:Insulin-like growth factor binding protein
3062:
3048:
3040:
2731:
2717:
2709:
2535:Annals of the New York Academy of Sciences
890:
830:maintenance of gastrointestinal epithelium
658:retinol transmembrane transporter activity
640:
428:
327:
224:
74:
2680:at the U.S. National Library of Medicine
2630:
2595:
2515:
2472:
2429:
2394:
2301:
2184:
2141:
2008:
1916:
1867:
1766:
1690:
1641:
1528:
564:fetal liver hematopoietic progenitor cell
2383:The Journal of Investigative Dermatology
2377:Siegenthaler G, Saurat JH (April 1987).
1593:
1591:
1305:In serum, TTR and RBP4 bind in a 1 to 1
860:positive regulation of insulin secretion
2746:
1425:
1348:RBP4 has recently been described as an
1274:family and is the specific carrier for
29:
1848:The Journal of Clinical Investigation
1671:The Journal of Clinical Investigation
805:embryonic skeletal system development
392:
353:
348:
291:
250:
245:
7:
1942:Molecular and Cellular Endocrinology
1610:
1608:
2701:(Retinol-binding protein 4) at the
2619:The Journal of Biological Chemistry
2418:The Journal of Biological Chemistry
1554:Somatic Cell and Molecular Genetics
1258:bound to retinol in a complex with
678:protein heterodimerization activity
2555:10.1111/j.1749-6632.1981.tb12739.x
2508:10.1002/j.1460-2075.1984.tb01995.x
2294:10.1002/j.1460-2075.1985.tb03881.x
2186:10.1111/j.1432-1033.1979.tb13263.x
2109:10.1111/j.1432-1033.1979.tb12896.x
1517:Upsala Journal of Medical Sciences
1142:
1113:
1083:
1054:
1030:
1011:
985:
966:
940:
921:
610:
528:
466:
445:
25:
3404:Cholesterylester transfer protein
775:cardiac muscle tissue development
3019:
3004:
2989:
2974:
2959:
2944:
2929:
2914:
2899:
2884:
2869:
2854:
2839:
2824:
2809:
2794:
2779:
2764:
2749:
2173:European Journal of Biochemistry
2097:European Journal of Biochemistry
1842:Herman MA, Kahn BB (July 2006).
614:
376:
369:
363:
340:
275:
268:
262:
237:
38:
3419:Latent TGF-beta binding protein
3368:Photosynthetic Reaction Centers
3353:Plant Light-Harvesting Complex
3146:Growth hormone binding protein
1622:Journal of Medicinal Chemistry
815:female genitalia morphogenesis
625:More reference expression data
594:More reference expression data
1:
2632:10.1016/S0021-9258(17)31527-2
2597:10.1016/S0022-2275(20)41132-0
2431:10.1016/S0021-9258(19)34162-6
2080:10.1016/s0167-4838(00)00150-3
2051:10.1016/S0098-2997(03)00038-4
2039:Molecular Aspects of Medicine
800:embryonic organ morphogenesis
580:tunica media of zone of aorta
361:
260:
3465:Peripheral membrane proteins
3455:Genes on human chromosome 10
3216:Sex hormone binding globulin
2396:10.1111/1523-1747.ep12469731
2143:10.1016/0014-5793(79)81084-4
1270:This protein belongs to the
3261:Calmodulin-binding proteins
790:urinary bladder development
490:subcutaneous adipose tissue
3481:
3429:Membrane transport protein
3230:Thyroxine-binding globulin
2001:10.1016/j.cell.2015.03.006
1909:10.1016/j.cmet.2014.01.018
810:retinoid metabolic process
729:protein-containing complex
568:tunica adventitia of aorta
3358:Orange Carotenoid Protein
2744:
2584:Journal of Lipid Research
2342:The Histochemical Journal
1954:10.1016/j.mce.2009.08.018
1530:10.3109/03009738709178685
1494:"Mouse PubMed Reference:"
1476:"Human PubMed Reference:"
1233:Retinol binding protein 4
1219:
1214:
1210:
1203:
1187:
1168:
1149:
1120:
1109:
1090:
1061:
1050:
1037:
1033:
1018:
1014:
1005:
992:
988:
973:
969:
960:
947:
943:
928:
924:
915:
900:
893:
889:
873:
795:retinol metabolic process
760:response to retinoic acid
755:heart trabecula formation
643:
639:
622:
613:
604:
591:
540:
531:
478:
469:
439:
431:
427:
410:
397:
360:
339:
330:
326:
309:
296:
259:
236:
227:
223:
178:
175:
165:
158:
153:
82:
77:
60:
55:
50:
46:
37:
32:
3220:Androgen binding protein
2682:Medical Subject Headings
1334:. An animal study using
1181:Chr 19: 38.11 – 38.11 Mb
3434:Odorant binding protein
3308:Retinol binding protein
3256:Calcium-binding protein
1174:Chr 10: 93.59 – 93.6 Mb
27:Protein found in humans
3424:Major urinary proteins
2465:10.1093/nar/11.22.7769
2453:Nucleic Acids Research
2253:10.1002/prot.340080108
1299:
693:small molecule binding
394:19 C2|19 32.75 cM
3285:Iron-binding proteins
2216:10.1002/bip.360320425
1317:Clinical significance
1297:
719:extracellular exosome
355:Chromosome 19 (mouse)
253:Chromosome 10 (human)
3394:Acyl carrier protein
3290:Transferrin receptor
1768:10.1167/iovs.05-0820
1352:that contributes to
1332:macular degeneration
770:response to stimulus
714:extracellular region
663:transporter activity
560:brown adipose tissue
556:white adipose tissue
78:List of PDB id codes
51:Available structures
3414:GTP-binding protein
2678:RBP4+protein,+human
2547:1981NYASA.359...79R
1813:10.1038/nature03711
1805:2005Natur.436..356Y
1415:Transthyretin (TTR)
1328:Stargardt's disease
1239:, is a transporter
845:response to ethanol
765:glucose homeostasis
724:extracellular space
482:right lobe of liver
2354:10.1007/BF01676116
1566:10.1007/BF01535081
1354:insulin resistance
1300:
995:ENSMUSG00000024990
820:uterus development
785:vagina development
738:Biological process
702:Cellular component
651:Molecular function
544:left lobe of liver
498:anterior pituitary
3442:
3441:
3037:
3036:
1728:10.1021/bi982291i
1683:10.1172/jci105889
1634:10.1021/jm5010013
1375:Mutations in the
1230:
1229:
1226:
1225:
1199:
1198:
1164:
1163:
1139:
1138:
1105:
1104:
1080:
1079:
1046:
1045:
1027:
1026:
1001:
1000:
982:
981:
956:
955:
937:
936:
885:
884:
855:visual perception
835:retinol transport
825:heart development
635:
634:
631:
630:
600:
599:
587:
586:
576:lactiferous gland
525:
524:
423:
422:
322:
321:
149:
148:
145:
144:
61:Ortholog search:
16:(Redirected from
3472:
3363:Phycobiliprotein
3075:carrier proteins
3064:
3057:
3050:
3041:
3023:
3008:
2993:
2978:
2963:
2948:
2933:
2918:
2903:
2888:
2873:
2858:
2843:
2828:
2813:
2798:
2783:
2768:
2753:
2733:
2726:
2719:
2710:
2666:
2644:
2634:
2609:
2599:
2574:
2529:
2519:
2496:The EMBO Journal
2486:
2476:
2443:
2433:
2408:
2398:
2373:
2336:
2315:
2305:
2282:The EMBO Journal
2272:
2235:
2198:
2188:
2163:
2145:
2120:
2091:
2062:
2023:
2022:
2012:
1980:
1974:
1973:
1937:
1931:
1930:
1920:
1888:
1882:
1881:
1871:
1860:10.1172/JCI29027
1839:
1833:
1832:
1799:(7049): 356–62.
1787:
1781:
1780:
1770:
1761:(12): 4393–401.
1746:
1740:
1739:
1711:
1705:
1704:
1694:
1662:
1656:
1655:
1645:
1612:
1603:
1602:
1595:
1586:
1585:
1549:
1543:
1542:
1532:
1508:
1502:
1501:
1490:
1484:
1483:
1472:
1466:
1456:
1445:
1435:
1235:, also known as
1212:
1211:
1183:
1176:
1159:
1143:
1134:
1114:
1110:RefSeq (protein)
1100:
1084:
1075:
1055:
1031:
1012:
986:
967:
941:
922:
891:
780:lung development
673:retinoid binding
641:
627:
618:
611:
596:
536:
534:Top expressed in
529:
474:
472:Top expressed in
467:
446:
429:
419:
406:
395:
380:
373:
367:
356:
344:
328:
318:
305:
294:
279:
272:
266:
255:
241:
225:
219:
217:RBP4 - orthologs
170:
163:
140:
75:
69:
48:
47:
42:
30:
21:
3480:
3479:
3475:
3474:
3473:
3471:
3470:
3469:
3445:
3444:
3443:
3438:
3399:Adaptor protein
3382:
3339:
3296:
3239:
3212:steroid hormone
3137:peptide hormone
3125:
3077:
3068:
3038:
3033:
3030:
3024:
3015:
3009:
3000:
2994:
2985:
2979:
2970:
2964:
2955:
2949:
2940:
2934:
2925:
2919:
2910:
2904:
2895:
2889:
2880:
2874:
2865:
2859:
2850:
2844:
2835:
2829:
2820:
2814:
2805:
2799:
2790:
2784:
2775:
2769:
2760:
2754:
2740:
2737:
2674:
2669:
2647:
2625:(38): 23395–8.
2612:
2577:
2532:
2489:
2459:(22): 7769–76.
2446:
2424:(21): 6638–46.
2411:
2376:
2339:
2318:
2275:
2238:
2201:
2166:
2123:
2094:
2065:
2035:
2031:
2029:Further reading
2026:
1982:
1981:
1977:
1939:
1938:
1934:
1897:Cell Metabolism
1890:
1889:
1885:
1841:
1840:
1836:
1789:
1788:
1784:
1748:
1747:
1743:
1713:
1712:
1708:
1664:
1663:
1659:
1628:(18): 7731–57.
1614:
1613:
1606:
1597:
1596:
1589:
1551:
1550:
1546:
1510:
1509:
1505:
1492:
1491:
1487:
1474:
1473:
1469:
1457:
1448:
1436:
1427:
1423:
1401:
1319:
1292:
1268:
1221:View/Edit Mouse
1216:View/Edit Human
1179:
1172:
1169:Location (UCSC)
1155:
1151:
1130:
1126:
1122:
1096:
1092:
1071:
1067:
1063:
976:ENSG00000138207
869:
750:gluconeogenesis
745:eye development
733:
697:
688:retinal binding
683:retinol binding
668:protein binding
623:
592:
583:
578:
574:
570:
566:
562:
558:
554:
550:
546:
532:
521:
516:
512:
508:
504:
500:
496:
494:pituitary gland
492:
488:
484:
470:
414:
401:
393:
383:
382:
381:
374:
354:
331:Gene location (
313:
300:
292:
282:
281:
280:
273:
251:
228:Gene location (
179:
166:
159:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3478:
3476:
3468:
3467:
3462:
3457:
3447:
3446:
3440:
3439:
3437:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3390:
3388:
3384:
3383:
3381:
3380:
3375:
3370:
3365:
3360:
3355:
3349:
3347:
3341:
3340:
3338:
3337:
3335:Transcobalamin
3332:
3331:
3330:
3325:
3320:
3315:
3304:
3302:
3298:
3297:
3295:
3294:
3293:
3292:
3287:
3277:
3276:
3275:
3265:
3264:
3263:
3258:
3247:
3245:
3241:
3240:
3238:
3237:
3232:
3227:
3222:
3208:
3207:
3206:
3205:
3200:
3190:
3189:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3148:
3143:
3133:
3131:
3127:
3126:
3124:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3087:
3085:
3079:
3078:
3069:
3067:
3066:
3059:
3052:
3044:
3035:
3034:
3032:
3031:
3025:
3018:
3016:
3010:
3003:
3001:
2995:
2988:
2986:
2980:
2973:
2971:
2965:
2958:
2956:
2950:
2943:
2941:
2935:
2928:
2926:
2920:
2913:
2911:
2905:
2898:
2896:
2890:
2883:
2881:
2875:
2868:
2866:
2860:
2853:
2851:
2845:
2838:
2836:
2830:
2823:
2821:
2815:
2808:
2806:
2800:
2793:
2791:
2785:
2778:
2776:
2770:
2763:
2761:
2755:
2748:
2745:
2742:
2741:
2738:
2736:
2735:
2728:
2721:
2713:
2707:
2706:
2685:
2673:
2672:External links
2670:
2668:
2667:
2645:
2610:
2590:(6): 1247–53.
2575:
2530:
2487:
2444:
2409:
2374:
2337:
2327:(7): 1031–40.
2316:
2273:
2236:
2199:
2164:
2121:
2092:
2074:(1–2): 57–64.
2063:
2032:
2030:
2027:
2025:
2024:
1995:(3): 634–646.
1975:
1932:
1883:
1854:(7): 1767–75.
1834:
1782:
1741:
1722:(9): 2647–53.
1706:
1677:(9): 2025–44.
1657:
1604:
1587:
1544:
1503:
1485:
1467:
1446:
1424:
1422:
1419:
1418:
1417:
1412:
1407:
1400:
1397:
1366:the fat tissue
1339:knockout mouse
1318:
1315:
1291:
1288:
1267:
1264:
1228:
1227:
1224:
1223:
1218:
1208:
1207:
1201:
1200:
1197:
1196:
1194:
1192:
1185:
1184:
1177:
1170:
1166:
1165:
1162:
1161:
1147:
1146:
1140:
1137:
1136:
1118:
1117:
1111:
1107:
1106:
1103:
1102:
1088:
1087:
1081:
1078:
1077:
1059:
1058:
1052:
1048:
1047:
1044:
1043:
1035:
1034:
1028:
1025:
1024:
1016:
1015:
1009:
1003:
1002:
999:
998:
990:
989:
983:
980:
979:
971:
970:
964:
958:
957:
954:
953:
945:
944:
938:
935:
934:
926:
925:
919:
913:
912:
907:
902:
898:
897:
887:
886:
883:
882:
871:
870:
868:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
741:
739:
735:
734:
732:
731:
726:
721:
716:
711:
705:
703:
699:
698:
696:
695:
690:
685:
680:
675:
670:
665:
660:
654:
652:
648:
647:
637:
636:
633:
632:
629:
628:
620:
619:
608:
602:
601:
598:
597:
589:
588:
585:
584:
582:
581:
577:
573:
569:
565:
561:
557:
553:
549:
545:
541:
538:
537:
526:
523:
522:
520:
519:
515:
514:synovial joint
511:
507:
503:
499:
495:
491:
487:
483:
479:
476:
475:
463:
462:
454:
443:
437:
436:
433:RNA expression
425:
424:
421:
420:
412:
408:
407:
399:
396:
391:
385:
384:
375:
368:
362:
358:
357:
352:
346:
345:
337:
336:
324:
323:
320:
319:
311:
307:
306:
298:
295:
290:
284:
283:
274:
267:
261:
257:
256:
249:
243:
242:
234:
233:
221:
220:
177:
173:
172:
164:
156:
155:
151:
150:
147:
146:
143:
142:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3477:
3466:
3463:
3461:
3458:
3456:
3453:
3452:
3450:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3409:F-box protein
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3391:
3389:
3385:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3350:
3348:
3346:
3342:
3336:
3333:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3310:
3309:
3306:
3305:
3303:
3299:
3291:
3288:
3286:
3283:
3282:
3281:
3278:
3274:
3273:Ceruloplasmin
3271:
3270:
3269:
3266:
3262:
3259:
3257:
3254:
3253:
3252:
3249:
3248:
3246:
3244:Metal/element
3242:
3236:
3235:Transthyretin
3233:
3231:
3228:
3226:
3223:
3221:
3217:
3213:
3210:
3209:
3204:
3201:
3199:
3198:Neurophysin I
3196:
3195:
3194:
3191:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3153:
3152:
3149:
3147:
3144:
3142:
3138:
3135:
3134:
3132:
3128:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3088:
3086:
3084:
3080:
3076:
3072:
3065:
3060:
3058:
3053:
3051:
3046:
3045:
3042:
3028:
3022:
3017:
3013:
3007:
3002:
2998:
2992:
2987:
2983:
2977:
2972:
2968:
2962:
2957:
2953:
2947:
2942:
2938:
2932:
2927:
2923:
2917:
2912:
2908:
2902:
2897:
2893:
2887:
2882:
2878:
2872:
2867:
2863:
2857:
2852:
2848:
2842:
2837:
2833:
2827:
2822:
2818:
2812:
2807:
2803:
2797:
2792:
2788:
2782:
2777:
2773:
2767:
2762:
2758:
2752:
2747:
2743:
2734:
2729:
2727:
2722:
2720:
2715:
2714:
2711:
2704:
2700:
2699:
2694:
2690:
2686:
2683:
2679:
2676:
2675:
2671:
2664:
2660:
2656:
2652:
2646:
2642:
2638:
2633:
2628:
2624:
2620:
2616:
2611:
2607:
2603:
2598:
2593:
2589:
2585:
2581:
2576:
2572:
2568:
2564:
2560:
2556:
2552:
2548:
2544:
2540:
2536:
2531:
2527:
2523:
2518:
2513:
2509:
2505:
2502:(7): 1451–4.
2501:
2497:
2493:
2488:
2484:
2480:
2475:
2470:
2466:
2462:
2458:
2454:
2450:
2445:
2441:
2437:
2432:
2427:
2423:
2419:
2415:
2410:
2406:
2402:
2397:
2392:
2388:
2384:
2380:
2375:
2371:
2367:
2363:
2359:
2355:
2351:
2347:
2343:
2338:
2334:
2330:
2326:
2322:
2317:
2313:
2309:
2304:
2299:
2295:
2291:
2288:(8): 1981–9.
2287:
2283:
2279:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2237:
2233:
2229:
2225:
2221:
2217:
2213:
2210:(4): 457–65.
2209:
2205:
2200:
2196:
2192:
2187:
2182:
2179:(2): 353–60.
2178:
2174:
2170:
2165:
2161:
2157:
2153:
2149:
2144:
2139:
2135:
2131:
2127:
2122:
2118:
2114:
2110:
2106:
2103:(1): 307–13.
2102:
2098:
2093:
2089:
2085:
2081:
2077:
2073:
2069:
2064:
2060:
2056:
2052:
2048:
2045:(6): 421–30.
2044:
2040:
2034:
2033:
2028:
2020:
2016:
2011:
2006:
2002:
1998:
1994:
1990:
1986:
1979:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1948:(2): 129–39.
1947:
1943:
1936:
1933:
1928:
1924:
1919:
1914:
1910:
1906:
1903:(3): 512–26.
1902:
1898:
1894:
1887:
1884:
1879:
1875:
1870:
1865:
1861:
1857:
1853:
1849:
1845:
1838:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1802:
1798:
1794:
1786:
1783:
1778:
1774:
1769:
1764:
1760:
1756:
1752:
1745:
1742:
1737:
1733:
1729:
1725:
1721:
1717:
1710:
1707:
1702:
1698:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1661:
1658:
1653:
1649:
1644:
1639:
1635:
1631:
1627:
1623:
1619:
1611:
1609:
1605:
1600:
1594:
1592:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1560:(2): 185–90.
1559:
1555:
1548:
1545:
1540:
1536:
1531:
1526:
1523:(2): 115–46.
1522:
1518:
1514:
1507:
1504:
1499:
1495:
1489:
1486:
1481:
1477:
1471:
1468:
1464:
1460:
1455:
1453:
1451:
1447:
1443:
1439:
1434:
1432:
1430:
1426:
1420:
1416:
1413:
1411:
1408:
1406:
1403:
1402:
1398:
1396:
1393:
1388:
1383:
1378:
1373:
1371:
1367:
1363:
1359:
1355:
1351:
1346:
1344:
1340:
1337:
1333:
1329:
1325:
1316:
1314:
1312:
1308:
1307:stoichiometry
1303:
1296:
1289:
1287:
1285:
1281:
1280:transthyretin
1277:
1273:
1265:
1263:
1261:
1260:transthyretin
1257:
1253:
1250:
1246:
1242:
1238:
1234:
1222:
1217:
1213:
1209:
1206:
1202:
1195:
1193:
1190:
1186:
1182:
1178:
1175:
1171:
1167:
1160:
1158:
1154:
1148:
1144:
1141:
1135:
1133:
1129:
1125:
1119:
1115:
1112:
1108:
1101:
1099:
1095:
1089:
1085:
1082:
1076:
1074:
1070:
1066:
1060:
1056:
1053:
1051:RefSeq (mRNA)
1049:
1042:
1041:
1036:
1032:
1029:
1023:
1022:
1017:
1013:
1010:
1008:
1004:
997:
996:
991:
987:
984:
978:
977:
972:
968:
965:
963:
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
911:
908:
906:
903:
899:
896:
892:
888:
881:
877:
872:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
742:
740:
737:
736:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
706:
704:
701:
700:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
655:
653:
650:
649:
646:
645:Gene ontology
642:
638:
626:
621:
617:
612:
609:
607:
603:
595:
590:
579:
575:
571:
567:
563:
559:
555:
551:
547:
543:
542:
539:
535:
530:
527:
517:
513:
509:
505:
502:abdominal fat
501:
497:
493:
489:
485:
481:
480:
477:
473:
468:
465:
464:
461:
459:
455:
453:
452:
448:
447:
444:
442:
438:
434:
430:
426:
418:
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405:
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390:
386:
379:
372:
366:
359:
351:
347:
343:
338:
334:
329:
325:
317:
312:
308:
304:
299:
289:
285:
278:
271:
265:
258:
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248:
244:
240:
235:
231:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
174:
169:
162:
157:
152:
141:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3327:
3279:
3267:
3250:
3193:Neurophysins
3026:
3011:
2996:
2981:
2966:
2951:
2936:
2921:
2906:
2891:
2876:
2861:
2846:
2831:
2816:
2801:
2786:
2771:
2756:
2696:
2654:
2650:
2622:
2618:
2587:
2583:
2541:(1): 79–90.
2538:
2534:
2499:
2495:
2456:
2452:
2421:
2417:
2389:(4): 403–8.
2386:
2382:
2348:(4): 164–8.
2345:
2341:
2324:
2320:
2285:
2281:
2247:(1): 44–61.
2244:
2240:
2207:
2203:
2176:
2172:
2133:
2130:FEBS Letters
2129:
2100:
2096:
2071:
2067:
2042:
2038:
1992:
1988:
1978:
1945:
1941:
1935:
1900:
1896:
1886:
1851:
1847:
1837:
1796:
1792:
1785:
1758:
1754:
1744:
1719:
1716:Biochemistry
1715:
1709:
1674:
1670:
1660:
1625:
1621:
1557:
1553:
1547:
1520:
1516:
1506:
1497:
1488:
1479:
1470:
1391:
1386:
1381:
1376:
1374:
1347:
1320:
1304:
1301:
1269:
1248:
1236:
1232:
1231:
1153:NP_001152959
1150:
1128:NP_001310447
1124:NP_001310446
1121:
1094:NM_001159487
1091:
1073:NM_001323518
1069:NM_001323517
1062:
1038:
1019:
993:
974:
948:
929:
909:
904:
456:
449:
176:External IDs
83:
3373:Phytochrome
3225:Transcortin
3141:Follistatin
2739:PDB gallery
2657:(1): 3–11.
2204:Biopolymers
2136:(1): 55–8.
1370:macrophages
1343:Fenretinide
572:human fetus
552:gallbladder
506:skin of hip
415:38,113,729
402:38,105,077
314:93,601,744
301:93,591,687
154:Identifiers
3460:Lipocalins
3449:Categories
3083:Fatty acid
1465:, May 2017
1444:, May 2017
1421:References
1362:adipocytes
1324:lipofuscin
1256:hepatokine
460:(ortholog)
197:HomoloGene
3378:Rhodopsin
1410:Adipokine
1350:adipokine
1290:Structure
1284:glomeruli
1272:lipocalin
1157:NP_035385
1132:NP_006735
1098:NM_011255
1065:NM_006744
895:Orthologs
865:transport
486:beta cell
205:GeneCards
3071:Proteins
2269:21613341
2241:Proteins
2232:34994569
2088:11058747
2059:14585313
2019:25910211
1962:19723556
1927:24606904
1878:16823474
1821:16034410
1777:16303925
1736:10052934
1652:25210858
1582:37896530
1461:–
1440:–
1399:See also
1358:diabetes
1266:Function
1205:Wikidata
874:Sources:
548:yolk sac
293:10q23.33
3345:Pigment
3301:Vitamin
3251:calcium
3130:Hormone
2703:PDBe-KB
2693:UniProt
2663:9888420
2641:8089102
2606:7666002
2571:5781208
2563:6942701
2543:Bibcode
2526:6540172
2483:6316270
2440:5132677
2405:3559267
2370:2959823
2362:3525470
2333:3013795
2312:2998779
2261:2217163
2224:1623143
2160:8540537
2010:4409664
1970:7385199
1918:4078000
1869:1483149
1829:4343960
1801:Bibcode
1701:5675424
1643:4174998
1574:2928844
1539:2444024
1463:Ensembl
1442:Ensembl
1405:Retinol
1311:daltons
1276:retinol
1245:retinol
1241:protein
1007:UniProt
962:Ensembl
901:Species
880:QuickGO
709:cytosol
518:decidua
435:pattern
161:Aliases
3268:copper
3186:IGFBP7
3181:IGFBP6
3176:IGFBP5
3171:IGFBP4
3166:IGFBP3
3161:IGFBP2
3156:IGFBP1
2698:P02753
2684:(MeSH)
2661:
2639:
2604:
2569:
2561:
2524:
2517:557543
2514:
2481:
2474:326530
2471:
2438:
2403:
2368:
2360:
2331:
2310:
2303:554451
2300:
2267:
2259:
2230:
2222:
2195:574085
2193:
2158:
2152:573217
2150:
2117:571335
2115:
2086:
2057:
2017:
2007:
1968:
1960:
1925:
1915:
1876:
1866:
1827:
1819:
1793:Nature
1775:
1734:
1699:
1692:297364
1689:
1650:
1640:
1580:
1572:
1537:
1191:search
1189:PubMed
1040:Q00724
1021:P02753
917:Entrez
606:BioGPS
185:180250
3387:Other
3121:FABP7
3116:FABP6
3111:FABP5
3106:FABP4
3101:FABP3
3096:FABP2
3091:FABP1
2567:S2CID
2366:S2CID
2265:S2CID
2228:S2CID
2156:S2CID
1966:S2CID
1825:S2CID
1578:S2CID
1336:ABCA4
950:19662
910:Mouse
905:Human
876:Amigo
510:tibia
458:Mouse
451:Human
398:Start
333:Mouse
297:Start
230:Human
193:97879
3280:iron
3027:1rlb
3012:1rbp
2997:1qab
2982:1kt7
2967:1kt6
2952:1kt5
2937:1kt4
2922:1kt3
2907:1jyj
2892:1jyd
2877:1hbq
2862:1hbp
2847:1fen
2832:1fem
2817:1fel
2802:1erb
2787:1brq
2772:1brp
2757:1aqb
2691:for
2659:PMID
2637:PMID
2602:PMID
2559:PMID
2522:PMID
2479:PMID
2436:PMID
2401:PMID
2358:PMID
2329:PMID
2308:PMID
2257:PMID
2220:PMID
2191:PMID
2148:PMID
2113:PMID
2084:PMID
2072:1482
2055:PMID
2015:PMID
1989:Cell
1958:PMID
1923:PMID
1874:PMID
1817:PMID
1773:PMID
1732:PMID
1697:PMID
1648:PMID
1570:PMID
1535:PMID
1392:RBP4
1387:RBP4
1382:RBP4
1377:RBP4
1356:and
1330:and
1252:gene
1249:RBP4
1243:for
1237:RBP4
931:5950
441:Bgee
389:Band
350:Chr.
288:Band
247:Chr.
209:RBP4
201:4908
181:OMIM
168:RBP4
138:4PSQ
134:4O9S
130:3FMZ
126:3BSZ
122:2WR6
118:2WQA
114:2WQ9
110:1RLB
106:1RBP
102:1QAB
98:1JYJ
94:1JYD
90:1BRQ
86:1BRP
67:RCSB
64:PDBe
33:RBP4
18:RBP4
2689:PDB
2627:doi
2623:269
2592:doi
2551:doi
2539:359
2512:PMC
2504:doi
2469:PMC
2461:doi
2426:doi
2422:246
2391:doi
2350:doi
2298:PMC
2290:doi
2249:doi
2212:doi
2181:doi
2138:doi
2134:104
2105:doi
2076:doi
2047:doi
2005:PMC
1997:doi
1993:161
1950:doi
1946:316
1913:PMC
1905:doi
1864:PMC
1856:doi
1852:116
1809:doi
1797:436
1763:doi
1724:doi
1687:PMC
1679:doi
1638:PMC
1630:doi
1562:doi
1525:doi
1364:of
1313:).
411:End
310:End
213:OMA
189:MGI
57:PDB
3451::
3214::
3203:II
3139::
3073::
2695::
2655:40
2653:.
2635:.
2621:.
2617:.
2600:.
2588:36
2586:.
2582:.
2565:.
2557:.
2549:.
2537:.
2520:.
2510:.
2498:.
2494:.
2477:.
2467:.
2457:11
2455:.
2451:.
2434:.
2420:.
2416:.
2399:.
2387:88
2385:.
2381:.
2364:.
2356:.
2346:18
2344:.
2325:27
2323:.
2306:.
2296:.
2284:.
2280:.
2263:.
2255:.
2243:.
2226:.
2218:.
2208:32
2206:.
2189:.
2177:99
2175:.
2171:.
2154:.
2146:.
2132:.
2128:.
2111:.
2101:94
2099:.
2082:.
2070:.
2053:.
2043:24
2041:.
2013:.
2003:.
1991:.
1987:.
1964:.
1956:.
1944:.
1921:.
1911:.
1901:19
1899:.
1895:.
1872:.
1862:.
1850:.
1846:.
1823:.
1815:.
1807:.
1795:.
1771:.
1759:46
1757:.
1753:.
1730:.
1720:38
1718:.
1695:.
1685:.
1675:47
1673:.
1669:.
1646:.
1636:.
1626:57
1624:.
1620:.
1607:^
1590:^
1576:.
1568:.
1558:15
1556:.
1533:.
1521:92
1519:.
1515:.
1496:.
1478:.
1449:^
1428:^
878:/
417:bp
404:bp
316:bp
303:bp
211:;
207::
203:;
199::
195:;
191::
187:;
183::
136:,
132:,
128:,
124:,
120:,
116:,
112:,
108:,
104:,
100:,
96:,
92:,
88:,
3328:4
3323:3
3318:2
3313:1
3218:/
3063:e
3056:t
3049:v
2732:e
2725:t
2718:v
2705:.
2665:.
2643:.
2629::
2608:.
2594::
2573:.
2553::
2545::
2528:.
2506::
2500:3
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2335:.
2314:.
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2286:4
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2245:8
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2197:.
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2162:.
2140::
2119:.
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2090:.
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2061:.
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1972:.
1952::
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1880:.
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215::
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