242:
219:
116:
141:
493:
248:
147:
1552:
1114:
Kielman MF, Smits R, Devi TS, Fodde R, Bernini LF (Aug 1993). "Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse".
255:
154:
1447:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1015:. The alternative name iRhom1 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane
726:
707:
77:
1621:
1413:
1597:
1616:
1096:
1078:
1476:
Flint J, Thomas K, Micklem G, et al. (1997). "The relationship between chromosome structure and function at a human telomeric region".
1513:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
241:
941:
218:
1207:
934:
1065:
1044:
140:
115:
1061:
1040:
57:
254:
153:
1590:
1158:
Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R (Jul 2005).
247:
146:
1414:"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16"
771:
65:
1160:"Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands"
752:
1223:"Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases"
1272:"Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling"
1583:
129:
1372:
44:
913:
862:
1501:
1189:
1140:
89:
1361:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
917:
892:
866:
841:
492:
1530:
1493:
1464:
1435:
1400:
1347:
1301:
1252:
1181:
1132:
37:
1567:
1522:
1485:
1456:
1425:
1390:
1380:
1337:
1291:
1283:
1242:
1234:
1171:
1124:
1016:
334:
265:
209:
164:
85:
309:
1376:
1296:
1271:
1247:
1222:
1460:
1395:
1360:
641:
636:
631:
626:
621:
616:
611:
606:
601:
585:
580:
575:
570:
565:
560:
544:
539:
534:
1610:
1563:
1526:
521:
1505:
1144:
1193:
327:
106:
69:
93:
1101:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1083:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1287:
410:
226:
123:
73:
1326:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
671:
470:
348:
293:
280:
192:
179:
81:
1439:
1430:
1404:
1385:
1351:
1305:
1256:
1185:
1534:
1497:
1468:
1136:
981:
976:
965:
816:
797:
48:, C16orf8, Dist1, EGFR-RS, gene-89, gene-90, hDist1, rhomboid 5 homolog 1
1489:
1238:
1176:
1159:
1128:
1005:
783:
738:
949:
693:
1551:
1342:
1325:
1270:
Zettl M, Adrain C, Strisovsky K, Lastun V, Freeman M (April 2011).
656:
652:
1559:
1012:
617:
regulation of epidermal growth factor receptor signaling pathway
501:
61:
1359:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
317:
1571:
1208:"Entrez Gene: RHBDF1 rhomboid 5 homolog 1 (Drosophila)"
482:
1412:Daniels RJ, Peden JF, Lloyd C, et al. (2001).
906:
885:
855:
834:
607:
regulation of proteasomal protein catabolic process
1324:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1057:
1055:
1053:
1036:
1034:
1032:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1062:GRCm38: Ensembl release 89: ENSMUSG00000020282
1591:
8:
1041:GRCh38: Ensembl release 89: ENSG00000007384
1598:
1584:
667:
517:
305:
204:
101:
1429:
1394:
1384:
1341:
1295:
1246:
1175:
632:negative regulation of protein secretion
1221:Lemberg MK, Freeman M (November 2007).
1028:
18:
269:
230:
225:
168:
127:
122:
7:
1548:
1546:
1570:. You can help Knowledge (XXG) by
903:
882:
852:
831:
807:
788:
762:
743:
717:
698:
535:serine-type endopeptidase activity
487:
405:
343:
322:
14:
1008:that in humans is encoded by the
1550:
491:
253:
246:
240:
217:
152:
145:
139:
114:
642:regulation of protein secretion
1622:Human chromosome 16 gene stubs
576:endoplasmic reticulum membrane
561:integral component of membrane
502:More reference expression data
471:More reference expression data
1:
1461:10.1016/S0378-1119(97)00411-3
622:cell population proliferation
238:
137:
1617:Genes on human chromosome 16
1527:10.1016/0378-1119(94)90802-8
1365:Proc. Natl. Acad. Sci. U.S.A
994:Inactive rhomboid protein 1
1638:
1545:
1288:10.1016/j.cell.2011.02.047
1097:"Mouse PubMed Reference:"
1079:"Human PubMed Reference:"
980:
975:
971:
964:
948:
929:
910:
889:
878:
859:
838:
827:
814:
810:
795:
791:
782:
769:
765:
750:
746:
737:
724:
720:
705:
701:
692:
677:
670:
666:
650:
520:
516:
499:
490:
481:
468:
449:medullary collecting duct
417:
408:
379:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1002:rhomboid family member 1
942:Chr 11: 32.16 – 32.17 Mb
996:(iRhom1) also known as
429:internal carotid artery
425:external carotid artery
421:interventricular septum
1386:10.1073/pnas.242603899
935:Chr 16: 0.06 – 0.08 Mb
271:11 A4|11 18.83 cM
581:endoplasmic reticulum
540:growth factor binding
371:right coronary artery
232:Chromosome 11 (mouse)
130:Chromosome 16 (human)
1431:10.1093/hmg/10.4.339
998:rhomboid 5 homolog 1
457:skin of external ear
375:left coronary artery
1377:2002PNAS...9916899M
1371:(26): 16899–16903.
383:canal of the cervix
1558:This article on a
1490:10.1038/ng0397-252
1239:10.1101/gr.6425307
1177:10.1002/dvdy.20450
1129:10.1007/BF00357090
772:ENSMUSG00000020282
612:protein processing
595:Biological process
554:Cellular component
528:Molecular function
94:RHBDF1 - orthologs
1579:
1578:
991:
990:
987:
986:
960:
959:
925:
924:
900:
899:
874:
873:
849:
848:
823:
822:
804:
803:
778:
777:
759:
758:
733:
732:
714:
713:
662:
661:
602:protein transport
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
1629:
1600:
1593:
1586:
1554:
1547:
1538:
1521:(1–2): 171–174.
1509:
1472:
1455:(1–2): 149–156.
1443:
1433:
1408:
1398:
1388:
1355:
1345:
1310:
1309:
1299:
1267:
1261:
1260:
1250:
1218:
1212:
1211:
1204:
1198:
1197:
1179:
1170:(4): 1315–1331.
1155:
1149:
1148:
1111:
1105:
1104:
1093:
1087:
1086:
1075:
1069:
1059:
1048:
1038:
1017:serine proteases
973:
972:
944:
937:
920:
904:
895:
883:
879:RefSeq (protein)
869:
853:
844:
832:
808:
789:
763:
744:
718:
699:
668:
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1637:
1636:
1632:
1631:
1630:
1628:
1627:
1626:
1607:
1606:
1605:
1604:
1543:
1541:
1512:
1475:
1446:
1418:Hum. Mol. Genet
1411:
1358:
1323:
1319:
1317:Further reading
1314:
1313:
1269:
1268:
1264:
1233:(11): 1634–46.
1220:
1219:
1215:
1206:
1205:
1201:
1157:
1156:
1152:
1113:
1112:
1108:
1095:
1094:
1090:
1077:
1076:
1072:
1060:
1051:
1039:
1030:
1025:
982:View/Edit Mouse
977:View/Edit Human
940:
933:
930:Location (UCSC)
916:
912:
891:
865:
861:
840:
753:ENSG00000007384
646:
590:
571:Golgi apparatus
549:
545:protein binding
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
367:ascending aorta
365:
363:tibial arteries
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1635:
1633:
1625:
1624:
1619:
1609:
1608:
1603:
1602:
1595:
1588:
1580:
1577:
1576:
1555:
1540:
1539:
1510:
1484:(3): 252–257.
1473:
1444:
1424:(4): 339–352.
1409:
1356:
1343:10.1038/ng1285
1320:
1318:
1315:
1312:
1311:
1262:
1213:
1199:
1150:
1123:(6): 314–323.
1106:
1088:
1070:
1049:
1027:
1026:
1024:
1021:
1004:(RHBDF1) is a
989:
988:
985:
984:
979:
969:
968:
962:
961:
958:
957:
955:
953:
946:
945:
938:
931:
927:
926:
923:
922:
908:
907:
901:
898:
897:
887:
886:
880:
876:
875:
872:
871:
857:
856:
850:
847:
846:
836:
835:
829:
825:
824:
821:
820:
812:
811:
805:
802:
801:
793:
792:
786:
780:
779:
776:
775:
767:
766:
760:
757:
756:
748:
747:
741:
735:
734:
731:
730:
722:
721:
715:
712:
711:
703:
702:
696:
690:
689:
684:
679:
675:
674:
664:
663:
660:
659:
648:
647:
645:
644:
639:
634:
629:
627:cell migration
624:
619:
614:
609:
604:
598:
596:
592:
591:
589:
588:
583:
578:
573:
568:
566:Golgi membrane
563:
557:
555:
551:
550:
548:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
433:primary oocyte
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
391:gastric mucosa
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1634:
1623:
1620:
1618:
1615:
1614:
1612:
1601:
1596:
1594:
1589:
1587:
1582:
1581:
1575:
1573:
1569:
1565:
1564:chromosome 16
1561:
1556:
1553:
1549:
1544:
1536:
1532:
1528:
1524:
1520:
1516:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1445:
1441:
1437:
1432:
1427:
1423:
1419:
1415:
1410:
1406:
1402:
1397:
1392:
1387:
1382:
1378:
1374:
1370:
1366:
1362:
1357:
1353:
1349:
1344:
1339:
1335:
1331:
1327:
1322:
1321:
1316:
1307:
1303:
1298:
1293:
1289:
1285:
1281:
1277:
1273:
1266:
1263:
1258:
1254:
1249:
1244:
1240:
1236:
1232:
1228:
1224:
1217:
1214:
1209:
1203:
1200:
1195:
1191:
1187:
1183:
1178:
1173:
1169:
1165:
1161:
1154:
1151:
1146:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1110:
1107:
1102:
1098:
1092:
1089:
1084:
1080:
1074:
1071:
1067:
1063:
1058:
1056:
1054:
1050:
1046:
1042:
1037:
1035:
1033:
1029:
1022:
1020:
1018:
1014:
1011:
1007:
1003:
999:
995:
983:
978:
974:
970:
967:
963:
956:
954:
951:
947:
943:
939:
936:
932:
928:
921:
919:
915:
909:
905:
902:
896:
894:
888:
884:
881:
877:
870:
868:
864:
858:
854:
851:
845:
843:
837:
833:
830:
828:RefSeq (mRNA)
826:
819:
818:
813:
809:
806:
800:
799:
794:
790:
787:
785:
781:
774:
773:
768:
764:
761:
755:
754:
749:
745:
742:
740:
736:
729:
728:
723:
719:
716:
710:
709:
704:
700:
697:
695:
691:
688:
685:
683:
680:
676:
673:
669:
665:
658:
654:
649:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
558:
556:
553:
552:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1572:expanding it
1557:
1542:
1518:
1514:
1481:
1477:
1452:
1448:
1421:
1417:
1368:
1364:
1336:(1): 40–45.
1333:
1329:
1282:(1): 79–91.
1279:
1275:
1265:
1230:
1226:
1216:
1202:
1167:
1163:
1153:
1120:
1116:
1109:
1100:
1091:
1082:
1073:
1009:
1001:
997:
993:
992:
914:NP_001278747
911:
890:
863:NM_001291818
860:
839:
815:
796:
770:
751:
725:
706:
686:
681:
453:carotid body
359:tibial nerve
333:
326:
53:External IDs
1117:Mamm Genome
637:proteolysis
395:sural nerve
292:32,172,300
279:32,159,585
31:Identifiers
1611:Categories
1478:Nat. Genet
1330:Nat. Genet
1227:Genome Res
1068:, May 2017
1047:, May 2017
1023:References
387:right lung
337:(ortholog)
74:HomoloGene
1562:on human
918:NP_034247
893:NP_071895
867:NM_010117
842:NM_022450
672:Orthologs
445:esophagus
82:GeneCards
1506:20630444
1440:11157797
1405:12477932
1352:14702039
1306:21439629
1257:17938163
1186:15965977
1145:24711956
1064:–
1043:–
966:Wikidata
651:Sources:
586:membrane
1535:8125298
1498:9054936
1469:9373149
1373:Bibcode
1297:3149277
1248:2045146
1194:7770266
1164:Dev Dyn
1137:8318735
1066:Ensembl
1045:Ensembl
1006:protein
784:UniProt
739:Ensembl
678:Species
657:QuickGO
312:pattern
191:76,355
178:58,059
170:16p13.3
38:Aliases
1533:
1504:
1496:
1467:
1438:
1403:
1396:139241
1393:
1350:
1304:
1294:
1255:
1245:
1192:
1184:
1143:
1135:
1010:RHBDF1
952:search
950:PubMed
817:Q6PIX5
798:Q96CC6
694:Entrez
483:BioGPS
86:RHBDF1
70:104328
62:614403
45:RHBDF1
22:RHBDF1
1566:is a
1502:S2CID
1190:S2CID
1141:S2CID
727:13650
708:64285
687:Mouse
682:Human
653:Amigo
437:ankle
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:32085
1568:stub
1560:gene
1531:PMID
1515:Gene
1494:PMID
1465:PMID
1449:Gene
1436:PMID
1401:PMID
1348:PMID
1302:PMID
1276:Cell
1253:PMID
1182:PMID
1133:PMID
1013:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1523:doi
1519:138
1486:doi
1457:doi
1453:200
1426:doi
1391:PMC
1381:doi
1338:doi
1292:PMC
1284:doi
1280:145
1243:PMC
1235:doi
1172:doi
1168:233
1125:doi
1000:or
441:lip
288:End
187:End
90:OMA
66:MGI
1613::
1529:.
1517:.
1500:.
1492:.
1482:15
1480:.
1463:.
1451:.
1434:.
1422:10
1420:.
1416:.
1399:.
1389:.
1379:.
1369:99
1367:.
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1346:.
1334:36
1332:.
1328:.
1300:.
1290:.
1278:.
1274:.
1251:.
1241:.
1231:17
1229:.
1225:.
1188:.
1180:.
1166:.
1162:.
1139:.
1131:.
1119:.
1099:.
1081:.
1052:^
1031:^
1019:.
655:/
294:bp
281:bp
193:bp
180:bp
88:;
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80:;
76::
72:;
68::
64:;
60::
1599:e
1592:t
1585:v
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1537:.
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1471:.
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1354:.
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1308:.
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1196:.
1174::
1147:.
1127::
1121:4
1103:.
1085:.
212:)
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