349:
326:
223:
248:
600:
36:
355:
254:
4685:
62:
1219:) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
2548:
2833:
2051:"Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route"
1702:"Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)"
2541:
2382:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2534:
362:
261:
2741:
3289:
4128:
2592:
2450:"Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK"
4237:
2975:
2862:
1561:"Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo"
1215:. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (
898:
184:
3250:
879:
2411:
del Peso L, González-García M, Page C, Herrera R, Nuñez G (Oct 1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt".
4223:
3688:
2579:
2561:
4325:
4206:
2349:"Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation"
2119:
Xing J, Ginty DD, Greenberg ME (Aug 1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase".
3912:
2781:
2314:"Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells"
1881:
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1371:
Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Feb 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression".
3976:
2951:
1353:
1335:
4705:
4232:
1643:"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase"
2766:
348:
4289:
3964:
1137:
1130:
4404:
3221:
3211:
2896:
1840:"Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential"
325:
3903:
1406:
4172:
3844:
3206:
3197:
1322:
1301:
4560:
1318:
2236:"Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA"
1965:"A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity"
1471:"Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity"
247:
222:
59:
3587:
3084:
3075:
2732:
2678:
1297:
4675:
2775:
1912:"Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase"
164:
1751:"14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity"
361:
260:
1228:
2526:
354:
253:
3799:
3617:
3113:
4545:
4661:
4648:
4635:
4622:
4609:
4596:
4583:
3789:
3784:
3779:
3769:
3764:
3759:
3749:
3544:
3319:
2915:
4555:
4509:
4452:
4012:
4003:
3954:
2720:
2565:
1212:
947:
172:
2269:
Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A (Jun 1997).
1420:
Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A (Jun 1997).
4457:
4312:
3735:
928:
924:
2008:"Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity"
4478:
4397:
3011:
4550:
3578:
2420:
2128:
1923:
1654:
1113:
236:
151:
4514:
1273:
1088:
1084:
1058:
1050:
1046:
1025:
1017:
4086:
4710:
4447:
4189:
4143:
2152:
2067:
2050:
2037:
196:
2485:"pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167"
1092:
1054:
1021:
3449:
3158:
2514:
2471:
2436:
2399:
2370:
2335:
2300:
2257:
2222:
2187:
2144:
2107:
2072:
2029:
1994:
1951:
1898:
1869:
1826:
1772:
1731:
1682:
1623:
1582:
1541:
1500:
1451:
1388:
599:
144:
52:
1520:"Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs"
192:
4493:
4488:
4462:
4390:
4042:
3284:
3274:
3269:
3187:
3178:
3108:
3099:
3045:
3036:
2693:
2504:
2496:
2461:
2428:
2391:
2360:
2325:
2290:
2282:
2247:
2212:
2177:
2136:
2097:
2062:
2019:
1984:
1976:
1941:
1931:
1890:
1859:
1851:
1816:
1808:
1762:
1721:
1713:
1672:
1662:
1613:
1572:
1531:
1490:
1482:
1441:
1433:
1380:
441:
372:
316:
271:
4540:
4524:
4437:
3868:
2939:
2934:
2929:
2164:
Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR (Aug 1996).
416:
35:
2201:"Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases"
744:
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
2424:
2132:
1927:
1658:
4689:
4578:
4519:
2295:
2270:
1963:
Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME (Oct 1993).
1726:
1701:
1446:
1421:
2509:
2484:
2395:
2182:
2165:
2086:"Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1"
2024:
2007:
1989:
1964:
1864:
1839:
1821:
1796:
1677:
1642:
1495:
1470:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
727:
722:
717:
712:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
4699:
4483:
4442:
2992:
2924:
1946:
1911:
1894:
1618:
1602:"A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob"
1601:
1486:
628:
20:
2156:
1518:
Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ (Apr 2003).
1384:
4432:
3863:
2688:
434:
213:
176:
2041:
2432:
2140:
200:
4656:
4591:
4427:
4069:
3701:
3641:
3524:
3444:
3168:
2271:"IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase"
1422:"IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase"
1358:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1340:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4684:
2286:
1916:
Proceedings of the
National Academy of Sciences of the United States of America
1647:
Proceedings of the
National Academy of Sciences of the United States of America
1437:
517:
4157:
2631:
333:
230:
180:
155:, HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, ribosomal protein S6 kinase A1, MAPKAPK1
2365:
2348:
2330:
2313:
2217:
2200:
2102:
2085:
1936:
1797:"Nuclear localization and regulation of erk- and rsk-encoded protein kinases"
1236:
4630:
4604:
3118:
2483:
Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA (Apr 1998).
2049:
Barge RM, de Koning JP, Pouwels K, Dong F, Löwenberg B, Touw IP (Mar 1996).
1667:
1298:
ENSG00000281877 GRCh38: Ensembl release 89: ENSG00000117676, ENSG00000281877
843:
662:
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
577:
455:
400:
387:
299:
286:
188:
2466:
2449:
2252:
2235:
1980:
1776:
1767:
1750:
1735:
1686:
1627:
1577:
1560:
1545:
1536:
1519:
1504:
2518:
2500:
2475:
2440:
2403:
2374:
2339:
2304:
2261:
2226:
2191:
2148:
2111:
2076:
2033:
1998:
1955:
1902:
1873:
1830:
1586:
1455:
1392:
1177:
1172:
3474:
3369:
3364:
3359:
1855:
1812:
1161:
992:
973:
1407:"Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1"
4133:
4111:
4106:
4096:
4091:
3893:
3883:
3878:
3873:
3858:
3853:
3504:
3469:
2708:
2703:
2698:
1717:
959:
910:
2166:"The signal-dependent coactivator CBP is a nuclear target for pp90RSK"
1211:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
81:
4643:
4413:
4363:
4358:
4353:
4348:
4343:
4338:
4333:
4284:
4279:
4274:
4269:
4264:
4247:
4242:
4116:
4101:
4052:
4047:
4032:
4027:
4022:
4017:
3991:
3986:
3981:
3969:
3947:
3942:
3834:
3809:
3484:
3309:
3304:
3299:
3294:
3279:
3123:
3060:
3055:
3050:
3026:
2852:
2847:
2821:
2816:
2811:
2801:
2796:
2786:
2626:
2557:
1193:
1145:
865:
1600:
Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T (Feb 2001).
4617:
4259:
4252:
4162:
4059:
3959:
3937:
3932:
3927:
3922:
3917:
3829:
3824:
3819:
3814:
3804:
3774:
3754:
3631:
3626:
3607:
3602:
3592:
3568:
3563:
3558:
3534:
3529:
3519:
3514:
3509:
3499:
3479:
3464:
3459:
3454:
3434:
3429:
3419:
3414:
3409:
3404:
3399:
3389:
3384:
3379:
3374:
3354:
3349:
3344:
3339:
3334:
3329:
3314:
3264:
3259:
3153:
3148:
3143:
3138:
3133:
3128:
3089:
3021:
3016:
2965:
2960:
2886:
2881:
2876:
2842:
2834:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2636:
2621:
2616:
2611:
2606:
2601:
1259:
1242:
828:
824:
4152:
4079:
4074:
4064:
4037:
3794:
3744:
3725:
3720:
3715:
3710:
3665:
3660:
3655:
3650:
3597:
3553:
3494:
3489:
3439:
3424:
3394:
3324:
3240:
3235:
3230:
3163:
3065:
3006:
3001:
2905:
2871:
2756:
2751:
2746:
2715:
2683:
2671:
2666:
2661:
2651:
2646:
2448:
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P (Jan 1998).
1253:
1248:
1216:
1200:
168:
4386:
4310:
3686:
2577:
2530:
1559:
Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (Jan 1999).
799:
regulation of DNA-templated transcription in response to stress
608:
4121:
2656:
2641:
1641:
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J (Sep 2004).
4382:
809:
positive regulation of transcription by RNA polymerase II
424:
2084:
Wong EV, Schaefer AW, Landreth G, Lemmon V (Jul 1996).
789:
positive regulation of hepatic stellate cell activation
4673:
589:
4569:
4533:
4502:
4471:
4420:
4324:
4222:
4205:
4188:
4171:
4142:
4002:
3902:
3843:
3734:
3700:
3640:
3616:
3577:
3543:
3249:
3220:
3196:
3177:
3098:
3074:
3035:
2991:
2974:
2950:
2914:
2895:
2861:
2832:
2765:
2731:
2591:
1700:Rolfe M, McLeod LE, Pratt PF, Proud CG (Jun 2005).
1106:
1077:
1039:
1010:
1314:
1312:
1310:
1293:
1291:
1289:
2312:Li HL, Forman MS, Kurosaki T, Puré E (Jul 1997).
677:protein serine/threonine/tyrosine kinase activity
371:
270:
749:regulation of translation in response to stress
19:"HU-1" redirects here. For the helicopter, see
1319:GRCm38: Ensembl release 89: ENSMUSG00000003644
4398:
2593:Non-specific serine/threonine protein kinases
2542:
8:
2068:10.1182/blood.V87.6.2148.bloodjournal8762148
1469:Roux PP, Richards SA, Blenis J (Jul 2003).
784:positive regulation of cell differentiation
4405:
4391:
4383:
4321:
4307:
3697:
3683:
2976:Goodpasture-antigen-binding protein kinase
2588:
2574:
2549:
2535:
2527:
2199:Zhao Y, Bjorbaek C, Moller DE (Nov 1996).
2006:Chen ZJ, Parent L, Maniatis T (Mar 1996).
1795:Chen RH, Sarnecki C, Blenis J (Mar 1992).
839:
624:
412:
311:
208:
70:
3689:Serine/threonine-specific protein kinases
2863:(isocitrate dehydrogenase (NADP+)) kinase
2580:Serine/threonine-specific protein kinases
2562:Serine/threonine-specific protein kinases
2508:
2465:
2364:
2329:
2294:
2251:
2216:
2181:
2101:
2066:
2023:
1988:
1945:
1935:
1863:
1820:
1766:
1725:
1676:
1666:
1617:
1576:
1535:
1494:
1445:
4224:Receptor protein serine/threonine kinase
1838:Tratner I, Ofir R, Verma IM (Mar 1992).
1749:Cavet ME, Lehoux S, Berk BC (May 2003).
764:negative regulation of apoptotic process
667:protein serine/threonine kinase activity
4680:
4207:Low-density-lipoprotein receptor kinase
1910:Chen RH, Abate C, Blenis J (Dec 1993).
1285:
532:crypt of lieberkuhn of small intestine
25:
2952:Fas-activated serine/threonine kinase
376:
337:
332:
275:
234:
229:
7:
4233:Bone morphogenetic protein receptors
697:ribosomal protein S6 kinase activity
552:vestibular membrane of cochlear duct
2767:Dephospho-(reductase kinase) kinase
2454:The Journal of Biological Chemistry
2353:The Journal of Biological Chemistry
2318:The Journal of Biological Chemistry
2240:The Journal of Biological Chemistry
2205:The Journal of Biological Chemistry
2090:The Journal of Biological Chemistry
1755:The Journal of Biological Chemistry
1565:The Journal of Biological Chemistry
1524:The Journal of Biological Chemistry
1190:Ribosomal protein S6 kinase alpha-1
3222:G-protein coupled receptor kinases
1373:The American Journal of Physiology
1103:
1074:
1036:
1007:
983:
964:
938:
915:
889:
870:
774:positive regulation of cell growth
594:
512:
450:
429:
14:
3212:Beta adrenergic receptor kinase-2
2897:(tyrosine 3-monooxygenase) kinase
1196:that in humans is encoded by the
754:intracellular signal transduction
4683:
3904:Mitogen-activated protein kinase
2347:Chang YW, Traugh JA (Nov 1997).
1619:10.1046/j.1365-2443.2001.00406.x
1487:10.1128/mcb.23.14.4796-4804.2003
598:
360:
353:
347:
324:
259:
252:
246:
221:
34:
4290:Anti-Müllerian hormone receptor
4173:(acetyl-CoA carboxylase) kinase
3845:(RNA-polymerase)-subunit kinase
3207:Beta adrenergic receptor kinase
3198:Beta adrenergic receptor kinase
1385:10.1152/ajpcell.1994.266.2.C351
3913:Extracellular signal-regulated
2489:Molecular and Cellular Biology
1969:Molecular and Cellular Biology
1844:Molecular and Cellular Biology
1801:Molecular and Cellular Biology
1475:Molecular and Cellular Biology
609:More reference expression data
578:More reference expression data
1:
3977:P38 mitogen-activated protein
3076:cGMP-dependent protein kinase
3037:cAMP-dependent protein kinase
2733:Pyruvate dehydrogenase kinase
2679:Ataxia telangiectasia mutated
2396:10.1016/S0378-1119(97)00411-3
2183:10.1016/S0092-8674(00)80119-1
2025:10.1016/S0092-8674(00)81064-8
345:
244:
2776:AMP-activated protein kinase
2433:10.1126/science.278.5338.687
2234:Zaheer A, Lim R (Feb 1997).
2141:10.1126/science.273.5277.959
1895:10.1016/0378-1119(94)90802-8
4706:Genes on human chromosome 1
3691:(EC 2.7.11.21-EC 2.7.11.30)
4727:
3618:Elongation factor 2 kinase
2582:(EC 2.7.11.1-EC 2.7.11.20)
1227:RPS6KA1 has been shown to
474:mucosa of transverse colon
18:
4561:Michaelis–Menten kinetics
4320:
4306:
4013:MAP kinase kinase kinases
3696:
3682:
3545:Myosin light-chain kinase
3251:Ca2+/calmodulin-dependent
2916:Myosin-heavy-chain kinase
2587:
2573:
1354:"Mouse PubMed Reference:"
1336:"Human PubMed Reference:"
1176:
1171:
1167:
1160:
1144:
1138:Chr 4: 133.57 – 133.62 Mb
1125:
1110:
1081:
1070:
1043:
1014:
1003:
990:
986:
971:
967:
958:
945:
941:
922:
918:
909:
896:
892:
877:
873:
864:
849:
842:
838:
822:
627:
623:
606:
597:
588:
575:
524:
515:
462:
453:
423:
415:
411:
394:
381:
344:
323:
314:
310:
293:
280:
243:
220:
211:
207:
162:
159:
149:
142:
137:
78:
73:
56:
51:
46:
42:
33:
28:
4453:Diffusion-limited enzyme
4313:Dual-specificity kinases
2366:10.1074/jbc.272.45.28252
2331:10.1074/jbc.272.29.18200
2287:10.1093/emboj/16.11.3133
2218:10.1074/jbc.271.47.29773
2103:10.1074/jbc.271.30.18217
1937:10.1073/pnas.90.23.10952
1438:10.1093/emboj/16.11.3133
1213:serine/threonine kinases
779:hepatocyte proliferation
3736:Cyclin-dependent kinase
1706:The Biochemical Journal
1668:10.1073/pnas.0405659101
1131:Chr 1: 26.53 – 26.58 Mb
769:protein phosphorylation
652:protein kinase activity
2467:10.1074/jbc.273.3.1496
2253:10.1074/jbc.272.8.5183
1981:10.1128/mcb.13.10.6260
1768:10.1074/jbc.M208475200
1578:10.1074/jbc.274.5.2893
1537:10.1074/jbc.M300485200
4546:Eadie–Hofstee diagram
4479:Allosteric regulation
2501:10.1128/mcb.18.4.1978
687:magnesium ion binding
564:epithelium of stomach
4556:Lineweaver–Burk plot
3579:Phosphorylase kinase
1856:10.1128/mcb.12.3.998
1813:10.1128/mcb.12.3.915
642:transferase activity
339:Chromosome 4 (mouse)
237:Chromosome 1 (human)
74:List of PDB id codes
47:Available structures
2425:1997Sci...278..687D
2133:1996Sci...273..959X
1928:1993PNAS...9010952C
1659:2004PNAS..10113489R
1274:Ribosomal s6 kinase
804:signal transduction
201:RPS6KA1 - orthologs
4515:Enzyme superfamily
4448:Enzyme promiscuity
4190:Tropomyosin kinase
4144:Tau-protein kinase
1718:10.1042/BJ20041888
1379:(2 Pt 1): C351–9.
948:ENSMUSG00000003644
737:Biological process
706:Cellular component
647:nucleotide binding
635:Molecular function
556:tibiofemoral joint
4671:
4670:
4380:
4379:
4376:
4375:
4372:
4371:
4302:
4301:
4298:
4297:
3678:
3677:
3674:
3673:
3159:Protein kinase N1
3114:Protein kinase Cζ
1187:
1186:
1183:
1182:
1156:
1155:
1121:
1120:
1100:
1099:
1066:
1065:
1033:
1032:
999:
998:
980:
979:
954:
953:
935:
934:
905:
904:
886:
885:
834:
833:
814:apoptotic process
657:metal ion binding
619:
618:
615:
614:
584:
583:
571:
570:
509:
508:
407:
406:
306:
305:
133:
132:
129:
128:
57:Ortholog search:
4718:
4688:
4687:
4679:
4551:Hanes–Woolf plot
4494:Enzyme activator
4489:Enzyme inhibitor
4463:Enzyme catalysis
4407:
4400:
4393:
4384:
4322:
4308:
3955:C-Jun N-terminal
3698:
3684:
3188:Rhodopsin kinase
3179:Rhodopsin kinase
3109:Protein kinase C
3100:Protein kinase C
3085:Protein kinase G
3046:Protein kinase A
2657:Protein kinase B
2589:
2575:
2551:
2544:
2537:
2528:
2522:
2512:
2479:
2469:
2444:
2407:
2378:
2368:
2343:
2333:
2308:
2298:
2275:The EMBO Journal
2265:
2255:
2230:
2220:
2195:
2185:
2160:
2127:(5277): 959–63.
2115:
2105:
2096:(30): 18217–23.
2080:
2070:
2045:
2027:
2002:
1992:
1959:
1949:
1939:
1906:
1877:
1867:
1834:
1824:
1781:
1780:
1770:
1761:(20): 18376–83.
1746:
1740:
1739:
1729:
1712:(Pt 3): 973–84.
1697:
1691:
1690:
1680:
1670:
1653:(37): 13489–94.
1638:
1632:
1631:
1621:
1597:
1591:
1590:
1580:
1556:
1550:
1549:
1539:
1530:(17): 14926–35.
1515:
1509:
1508:
1498:
1481:(14): 4796–804.
1466:
1460:
1459:
1449:
1426:The EMBO Journal
1417:
1411:
1410:
1403:
1397:
1396:
1368:
1362:
1361:
1350:
1344:
1343:
1332:
1326:
1316:
1305:
1295:
1169:
1168:
1140:
1133:
1116:
1104:
1095:
1075:
1071:RefSeq (protein)
1061:
1037:
1028:
1008:
984:
965:
939:
916:
890:
871:
840:
625:
611:
602:
595:
580:
520:
518:Top expressed in
513:
458:
456:Top expressed in
451:
430:
413:
403:
390:
379:
364:
357:
351:
340:
328:
312:
302:
289:
278:
263:
256:
250:
239:
225:
209:
203:
154:
147:
124:
71:
65:
44:
43:
38:
26:
4726:
4725:
4721:
4720:
4719:
4717:
4716:
4715:
4696:
4695:
4694:
4682:
4674:
4672:
4667:
4579:Oxidoreductases
4565:
4541:Enzyme kinetics
4529:
4525:List of enzymes
4498:
4467:
4438:Catalytic triad
4416:
4411:
4381:
4368:
4316:
4294:
4218:
4201:
4184:
4167:
4138:
3998:
3898:
3869:P70-S6 Kinase 1
3839:
3730:
3692:
3670:
3636:
3612:
3573:
3539:
3245:
3216:
3192:
3173:
3094:
3070:
3031:
2987:
2970:
2946:
2940:Aurora C kinase
2935:Aurora B kinase
2930:Aurora A kinase
2910:
2891:
2857:
2828:
2761:
2727:
2583:
2569:
2555:
2525:
2482:
2460:(3): 1496–505.
2447:
2419:(5338): 687–9.
2410:
2390:(1–2): 149–56.
2381:
2359:(45): 28252–7.
2346:
2324:(29): 18200–8.
2311:
2281:(11): 3133–44.
2268:
2233:
2211:(47): 29773–9.
2198:
2163:
2118:
2083:
2048:
2005:
1975:(10): 6260–73.
1962:
1922:(23): 10952–6.
1909:
1880:
1850:(3): 998–1006.
1837:
1794:
1790:
1788:Further reading
1785:
1784:
1748:
1747:
1743:
1699:
1698:
1694:
1640:
1639:
1635:
1599:
1598:
1594:
1558:
1557:
1553:
1517:
1516:
1512:
1468:
1467:
1463:
1432:(11): 3133–44.
1419:
1418:
1414:
1405:
1404:
1400:
1370:
1369:
1365:
1352:
1351:
1347:
1334:
1333:
1329:
1317:
1308:
1296:
1287:
1282:
1270:
1265:
1225:
1209:
1178:View/Edit Mouse
1173:View/Edit Human
1136:
1129:
1126:Location (UCSC)
1112:
1091:
1087:
1083:
1057:
1053:
1049:
1045:
1024:
1020:
1016:
929:ENSG00000281877
927:
925:ENSG00000117676
818:
759:phosphorylation
732:
701:
692:kinase activity
672:protein binding
607:
576:
567:
562:
558:
554:
550:
546:
542:
538:
534:
530:
516:
505:
500:
496:
492:
488:
484:
480:
476:
472:
468:
454:
398:
385:
377:
367:
366:
365:
358:
338:
315:Gene location (
297:
284:
276:
266:
265:
264:
257:
235:
212:Gene location (
163:
150:
143:
80:
58:
24:
17:
12:
11:
5:
4724:
4722:
4714:
4713:
4708:
4698:
4697:
4693:
4692:
4669:
4668:
4666:
4665:
4652:
4639:
4626:
4613:
4600:
4587:
4573:
4571:
4567:
4566:
4564:
4563:
4558:
4553:
4548:
4543:
4537:
4535:
4531:
4530:
4528:
4527:
4522:
4517:
4512:
4506:
4504:
4503:Classification
4500:
4499:
4497:
4496:
4491:
4486:
4481:
4475:
4473:
4469:
4468:
4466:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4424:
4422:
4418:
4417:
4412:
4410:
4409:
4402:
4395:
4387:
4378:
4377:
4374:
4373:
4370:
4369:
4367:
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4330:
4328:
4318:
4317:
4311:
4304:
4303:
4300:
4299:
4296:
4295:
4293:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4256:
4255:
4250:
4245:
4240:
4229:
4227:
4226:(EC 2.7.11.30)
4220:
4219:
4217:
4216:
4212:
4210:
4209:(EC 2.7.11.29)
4203:
4202:
4200:
4199:
4195:
4193:
4192:(EC 2.7.11.28)
4186:
4185:
4183:
4182:
4178:
4176:
4175:(EC 2.7.11.27)
4169:
4168:
4166:
4165:
4160:
4155:
4149:
4147:
4146:(EC 2.7.11.26)
4140:
4139:
4137:
4136:
4131:
4126:
4125:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4084:
4083:
4082:
4077:
4072:
4067:
4057:
4056:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4020:
4009:
4007:
4006:(EC 2.7.11.25)
4000:
3999:
3997:
3996:
3995:
3994:
3989:
3984:
3974:
3973:
3972:
3967:
3962:
3952:
3951:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3909:
3907:
3906:(EC 2.7.11.24)
3900:
3899:
3897:
3896:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3850:
3848:
3847:(EC 2.7.11.23)
3841:
3840:
3838:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3782:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3741:
3739:
3738:(EC 2.7.11.22)
3732:
3731:
3729:
3728:
3723:
3718:
3713:
3707:
3705:
3704:(EC 2.7.11.21)
3694:
3693:
3687:
3680:
3679:
3676:
3675:
3672:
3671:
3669:
3668:
3663:
3658:
3653:
3647:
3645:
3644:(EC 2.7.11.21)
3638:
3637:
3635:
3634:
3629:
3623:
3621:
3620:(EC 2.7.11.20)
3614:
3613:
3611:
3610:
3605:
3600:
3595:
3590:
3584:
3582:
3581:(EC 2.7.11.19)
3575:
3574:
3572:
3571:
3566:
3561:
3556:
3550:
3548:
3547:(EC 2.7.11.18)
3541:
3540:
3538:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3256:
3254:
3253:(EC 2.7.11.17)
3247:
3246:
3244:
3243:
3238:
3233:
3227:
3225:
3224:(EC 2.7.11.16)
3218:
3217:
3215:
3214:
3209:
3203:
3201:
3200:(EC 2.7.11.15)
3194:
3193:
3191:
3190:
3184:
3182:
3181:(EC 2.7.11.14)
3175:
3174:
3172:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3105:
3103:
3102:(EC 2.7.11.13)
3096:
3095:
3093:
3092:
3087:
3081:
3079:
3078:(EC 2.7.11.12)
3072:
3071:
3069:
3068:
3063:
3058:
3053:
3048:
3042:
3040:
3039:(EC 2.7.11.11)
3033:
3032:
3030:
3029:
3024:
3019:
3014:
3009:
3004:
2998:
2996:
2995:(EC 2.7.11.10)
2989:
2988:
2986:
2985:
2981:
2979:
2972:
2971:
2969:
2968:
2963:
2957:
2955:
2948:
2947:
2945:
2944:
2943:
2942:
2937:
2932:
2921:
2919:
2912:
2911:
2909:
2908:
2902:
2900:
2893:
2892:
2890:
2889:
2884:
2879:
2874:
2868:
2866:
2859:
2858:
2856:
2855:
2850:
2845:
2839:
2837:
2830:
2829:
2827:
2826:
2825:
2824:
2819:
2814:
2806:
2805:
2804:
2799:
2791:
2790:
2789:
2784:
2772:
2770:
2763:
2762:
2760:
2759:
2754:
2749:
2744:
2738:
2736:
2729:
2728:
2726:
2725:
2724:
2723:
2713:
2712:
2711:
2706:
2701:
2696:
2686:
2681:
2676:
2675:
2674:
2669:
2664:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2598:
2596:
2585:
2584:
2578:
2571:
2570:
2556:
2554:
2553:
2546:
2539:
2531:
2524:
2523:
2495:(4): 1978–84.
2480:
2445:
2408:
2379:
2344:
2309:
2266:
2231:
2196:
2161:
2116:
2081:
2061:(6): 2148–53.
2046:
2003:
1960:
1907:
1889:(1–2): 171–4.
1878:
1835:
1791:
1789:
1786:
1783:
1782:
1741:
1692:
1633:
1606:Genes to Cells
1592:
1551:
1510:
1461:
1412:
1398:
1363:
1345:
1327:
1306:
1284:
1283:
1281:
1278:
1277:
1276:
1269:
1266:
1264:
1263:
1257:
1251:
1246:
1240:
1233:
1224:
1221:
1208:
1205:
1185:
1184:
1181:
1180:
1175:
1165:
1164:
1158:
1157:
1154:
1153:
1151:
1149:
1142:
1141:
1134:
1127:
1123:
1122:
1119:
1118:
1114:NP_001272434.1
1108:
1107:
1101:
1098:
1097:
1079:
1078:
1072:
1068:
1067:
1064:
1063:
1041:
1040:
1034:
1031:
1030:
1012:
1011:
1005:
1001:
1000:
997:
996:
988:
987:
981:
978:
977:
969:
968:
962:
956:
955:
952:
951:
943:
942:
936:
933:
932:
920:
919:
913:
907:
906:
903:
902:
894:
893:
887:
884:
883:
875:
874:
868:
862:
861:
856:
851:
847:
846:
836:
835:
832:
831:
820:
819:
817:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
740:
738:
734:
733:
731:
730:
725:
720:
715:
709:
707:
703:
702:
700:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
638:
636:
632:
631:
621:
620:
617:
616:
613:
612:
604:
603:
592:
586:
585:
582:
581:
573:
572:
569:
568:
566:
565:
561:
560:gastric mucosa
557:
553:
549:
545:
541:
537:
533:
529:
525:
522:
521:
510:
507:
506:
504:
503:
499:
495:
491:
487:
483:
479:
475:
471:
467:
463:
460:
459:
447:
446:
438:
427:
421:
420:
417:RNA expression
409:
408:
405:
404:
396:
392:
391:
383:
380:
375:
369:
368:
359:
352:
346:
342:
341:
336:
330:
329:
321:
320:
308:
307:
304:
303:
295:
291:
290:
282:
279:
274:
268:
267:
258:
251:
245:
241:
240:
233:
227:
226:
218:
217:
205:
204:
161:
157:
156:
148:
140:
139:
135:
134:
131:
130:
127:
126:
76:
75:
67:
66:
55:
49:
48:
40:
39:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
4723:
4712:
4709:
4707:
4704:
4703:
4701:
4691:
4686:
4681:
4677:
4663:
4659:
4658:
4653:
4650:
4646:
4645:
4640:
4637:
4633:
4632:
4627:
4624:
4620:
4619:
4614:
4611:
4607:
4606:
4601:
4598:
4594:
4593:
4588:
4585:
4581:
4580:
4575:
4574:
4572:
4568:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4538:
4536:
4532:
4526:
4523:
4521:
4520:Enzyme family
4518:
4516:
4513:
4511:
4508:
4507:
4505:
4501:
4495:
4492:
4490:
4487:
4485:
4484:Cooperativity
4482:
4480:
4477:
4476:
4474:
4470:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4443:Oxyanion hole
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4425:
4423:
4419:
4415:
4408:
4403:
4401:
4396:
4394:
4389:
4388:
4385:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4331:
4329:
4327:
4323:
4319:
4314:
4309:
4305:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4235:
4234:
4231:
4230:
4228:
4225:
4221:
4214:
4213:
4211:
4208:
4204:
4197:
4196:
4194:
4191:
4187:
4180:
4179:
4177:
4174:
4170:
4164:
4161:
4159:
4156:
4154:
4151:
4150:
4148:
4145:
4141:
4135:
4132:
4130:
4127:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4089:
4088:
4085:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4062:
4061:
4058:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4015:
4014:
4011:
4010:
4008:
4005:
4001:
3993:
3990:
3988:
3985:
3983:
3980:
3979:
3978:
3975:
3971:
3968:
3966:
3963:
3961:
3958:
3957:
3956:
3953:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3915:
3914:
3911:
3910:
3908:
3905:
3901:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3851:
3849:
3846:
3842:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3742:
3740:
3737:
3733:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3708:
3706:
3703:
3699:
3695:
3690:
3685:
3681:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3648:
3646:
3643:
3639:
3633:
3630:
3628:
3625:
3624:
3622:
3619:
3615:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3585:
3583:
3580:
3576:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3551:
3549:
3546:
3542:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3257:
3255:
3252:
3248:
3242:
3239:
3237:
3234:
3232:
3229:
3228:
3226:
3223:
3219:
3213:
3210:
3208:
3205:
3204:
3202:
3199:
3195:
3189:
3186:
3185:
3183:
3180:
3176:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3106:
3104:
3101:
3097:
3091:
3088:
3086:
3083:
3082:
3080:
3077:
3073:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3043:
3041:
3038:
3034:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2999:
2997:
2994:
2990:
2983:
2982:
2980:
2978:(EC 2.7.11.9)
2977:
2973:
2967:
2964:
2962:
2959:
2958:
2956:
2954:(EC 2.7.11.8)
2953:
2949:
2941:
2938:
2936:
2933:
2931:
2928:
2927:
2926:
2925:Aurora kinase
2923:
2922:
2920:
2918:(EC 2.7.11.7)
2917:
2913:
2907:
2904:
2903:
2901:
2899:(EC 2.7.11.6)
2898:
2894:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2869:
2867:
2865:(EC 2.7.11.5)
2864:
2860:
2854:
2851:
2849:
2846:
2844:
2841:
2840:
2838:
2836:(EC 2.7.11.4)
2835:
2831:
2823:
2820:
2818:
2815:
2813:
2810:
2809:
2807:
2803:
2800:
2798:
2795:
2794:
2792:
2788:
2785:
2783:
2780:
2779:
2777:
2774:
2773:
2771:
2769:(EC 2.7.11.3)
2768:
2764:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2739:
2737:
2735:(EC 2.7.11.2)
2734:
2730:
2722:
2719:
2718:
2717:
2714:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2691:
2690:
2689:EIF-2 kinases
2687:
2685:
2682:
2680:
2677:
2673:
2670:
2668:
2665:
2663:
2660:
2659:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2599:
2597:
2595:(EC 2.7.11.1)
2594:
2590:
2586:
2581:
2576:
2572:
2567:
2563:
2559:
2552:
2547:
2545:
2540:
2538:
2533:
2532:
2529:
2520:
2516:
2511:
2506:
2502:
2498:
2494:
2490:
2486:
2481:
2477:
2473:
2468:
2463:
2459:
2455:
2451:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2418:
2414:
2409:
2405:
2401:
2397:
2393:
2389:
2385:
2380:
2376:
2372:
2367:
2362:
2358:
2354:
2350:
2345:
2341:
2337:
2332:
2327:
2323:
2319:
2315:
2310:
2306:
2302:
2297:
2292:
2288:
2284:
2280:
2276:
2272:
2267:
2263:
2259:
2254:
2249:
2246:(8): 5183–6.
2245:
2241:
2237:
2232:
2228:
2224:
2219:
2214:
2210:
2206:
2202:
2197:
2193:
2189:
2184:
2179:
2176:(3): 465–74.
2175:
2171:
2167:
2162:
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2130:
2126:
2122:
2117:
2113:
2109:
2104:
2099:
2095:
2091:
2087:
2082:
2078:
2074:
2069:
2064:
2060:
2056:
2052:
2047:
2043:
2039:
2035:
2031:
2026:
2021:
2018:(6): 853–62.
2017:
2013:
2009:
2004:
2000:
1996:
1991:
1986:
1982:
1978:
1974:
1970:
1966:
1961:
1957:
1953:
1948:
1943:
1938:
1933:
1929:
1925:
1921:
1917:
1913:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1879:
1875:
1871:
1866:
1861:
1857:
1853:
1849:
1845:
1841:
1836:
1832:
1828:
1823:
1818:
1814:
1810:
1807:(3): 915–27.
1806:
1802:
1798:
1793:
1792:
1787:
1778:
1774:
1769:
1764:
1760:
1756:
1752:
1745:
1742:
1737:
1733:
1728:
1723:
1719:
1715:
1711:
1707:
1703:
1696:
1693:
1688:
1684:
1679:
1674:
1669:
1664:
1660:
1656:
1652:
1648:
1644:
1637:
1634:
1629:
1625:
1620:
1615:
1611:
1607:
1603:
1596:
1593:
1588:
1584:
1579:
1574:
1571:(5): 2893–8.
1570:
1566:
1562:
1555:
1552:
1547:
1543:
1538:
1533:
1529:
1525:
1521:
1514:
1511:
1506:
1502:
1497:
1492:
1488:
1484:
1480:
1476:
1472:
1465:
1462:
1457:
1453:
1448:
1443:
1439:
1435:
1431:
1427:
1423:
1416:
1413:
1408:
1402:
1399:
1394:
1390:
1386:
1382:
1378:
1374:
1367:
1364:
1359:
1355:
1349:
1346:
1341:
1337:
1331:
1328:
1324:
1320:
1315:
1313:
1311:
1307:
1303:
1299:
1294:
1292:
1290:
1286:
1279:
1275:
1272:
1271:
1267:
1261:
1258:
1255:
1252:
1250:
1247:
1244:
1241:
1238:
1235:
1234:
1232:
1230:
1222:
1220:
1218:
1214:
1206:
1204:
1202:
1199:
1195:
1191:
1179:
1174:
1170:
1166:
1163:
1159:
1152:
1150:
1147:
1143:
1139:
1135:
1132:
1128:
1124:
1117:
1115:
1109:
1105:
1102:
1096:
1094:
1090:
1086:
1080:
1076:
1073:
1069:
1062:
1060:
1056:
1052:
1048:
1042:
1038:
1035:
1029:
1027:
1023:
1019:
1013:
1009:
1006:
1004:RefSeq (mRNA)
1002:
995:
994:
989:
985:
982:
976:
975:
970:
966:
963:
961:
957:
950:
949:
944:
940:
937:
931:
930:
926:
921:
917:
914:
912:
908:
901:
900:
895:
891:
888:
882:
881:
876:
872:
869:
867:
863:
860:
857:
855:
852:
848:
845:
841:
837:
830:
826:
821:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
741:
739:
736:
735:
729:
726:
724:
721:
719:
716:
714:
711:
710:
708:
705:
704:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
630:
629:Gene ontology
626:
622:
610:
605:
601:
596:
593:
591:
587:
579:
574:
563:
559:
555:
551:
547:
543:
539:
535:
531:
527:
526:
523:
519:
514:
511:
501:
497:
493:
489:
485:
481:
477:
473:
469:
465:
464:
461:
457:
452:
449:
448:
445:
443:
439:
437:
436:
432:
431:
428:
426:
422:
418:
414:
410:
402:
397:
393:
389:
384:
378:4|4 D2.3
374:
370:
363:
356:
350:
343:
335:
331:
327:
322:
318:
313:
309:
301:
296:
292:
288:
283:
273:
269:
262:
255:
249:
242:
238:
232:
228:
224:
219:
215:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
158:
153:
146:
141:
136:
125:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
22:
21:UH-1 Iroquois
4657:Translocases
4654:
4641:
4628:
4615:
4602:
4592:Transferases
4589:
4576:
4433:Binding site
3888:
3864:P70S6 kinase
2492:
2488:
2457:
2453:
2416:
2412:
2387:
2383:
2356:
2352:
2321:
2317:
2278:
2274:
2243:
2239:
2208:
2204:
2173:
2169:
2124:
2120:
2093:
2089:
2058:
2054:
2015:
2011:
1972:
1968:
1919:
1915:
1886:
1882:
1847:
1843:
1804:
1800:
1758:
1754:
1744:
1709:
1705:
1695:
1650:
1646:
1636:
1612:(2): 131–8.
1609:
1605:
1595:
1568:
1564:
1554:
1527:
1523:
1513:
1478:
1474:
1464:
1429:
1425:
1415:
1401:
1376:
1372:
1366:
1357:
1348:
1339:
1330:
1226:
1223:Interactions
1210:
1197:
1189:
1188:
1111:
1089:NP_001317370
1085:NP_001006666
1082:
1059:NM_001378880
1051:NM_001285506
1047:NM_001285505
1044:
1026:NM_001330441
1018:NM_001006665
1015:
991:
972:
946:
923:
897:
878:
858:
853:
440:
433:
399:133,615,108
386:133,574,601
160:External IDs
79:
4428:Active site
4315:(EC 2.7.12)
3702:Polo kinase
3642:Polo kinase
713:nucleoplasm
682:ATP binding
528:granulocyte
502:bone marrow
470:granulocyte
298:26,575,030
285:26,529,761
138:Identifiers
4700:Categories
4631:Isomerases
4605:Hydrolases
4472:Regulation
2993:IκB kinase
2568:2.7.11-12)
1325:, May 2017
1304:, May 2017
1280:References
794:cell cycle
540:left colon
490:lymph node
444:(ortholog)
181:HomoloGene
4711:EC 2.7.11
4510:EC number
3119:PKC alpha
1093:NP_002944
1055:NM_009097
1022:NM_002953
844:Orthologs
723:cytoplasm
189:GeneCards
4534:Kinetics
4458:Cofactor
4421:Activity
3475:KIAA0999
3370:MAPKAPK5
3365:MAPKAPK3
3360:MAPKAPK2
2157:22226803
1777:12618428
1736:15757502
1687:15342917
1628:11260258
1546:12594221
1505:12832467
1321:–
1300:–
1268:See also
1229:interact
1207:Function
1162:Wikidata
823:Sources:
536:duodenum
494:appendix
482:duodenum
478:monocyte
4690:Biology
4644:Ligases
4414:Enzymes
4134:MAP3K14
4112:MAP3K11
4107:MAP3K10
4097:MAP3K13
4092:MAP3K12
3894:RPS6KC1
3889:RPS6KA1
3884:RPS6KA3
3879:RPS6KA2
3874:RPS6KB2
3859:RPS6KA4
3854:RPS6KA5
3505:Kalirin
3470:SNF1LK2
2709:EIF2AK4
2704:EIF2AK3
2558:Kinases
2519:9528769
2476:9430688
2441:9381178
2421:Bibcode
2413:Science
2404:9373149
2375:9353277
2340:9218456
2305:9214631
2296:1169932
2262:9030586
2227:8939914
2192:8756728
2149:8688081
2129:Bibcode
2121:Science
2112:8663493
2077:8630373
2034:8601309
1999:8413226
1956:8248197
1924:Bibcode
1903:8125298
1874:1545828
1831:1545823
1727:1183479
1655:Bibcode
1587:9915826
1456:9214631
1447:1169932
1393:8141249
1323:Ensembl
1302:Ensembl
1198:RPS6KA1
960:UniProt
911:Ensembl
850:Species
829:QuickGO
728:cytosol
718:nucleus
544:jejunum
419:pattern
277:1p36.11
193:RPS6KA1
152:RPS6KA1
145:Aliases
29:RPS6KA1
4676:Portal
4618:Lyases
4364:MAP2K7
4359:MAP2K6
4354:MAP2K5
4349:MAP2K4
4344:MAP2K3
4339:MAP2K2
4334:MAP2K1
4285:ACVRL1
4280:ACVR2B
4275:ACVR2A
4270:ACVR1C
4265:ACVR1B
4248:BMPR1B
4243:BMPR1A
4117:MAP3K7
4102:MAP3K9
4053:MAP3K8
4048:MAP3K7
4043:MAP3K6
4038:MAP3K5
4033:MAP3K4
4028:MAP3K3
4023:MAP3K2
4018:MAP3K1
3992:MAPK14
3987:MAPK13
3982:MAPK11
3970:MAPK10
3948:MAPK15
3943:MAPK12
3835:CDC2L1
3810:CDC2L5
3485:SNF1LK
3310:CAMK2G
3305:CAMK2D
3300:CAMK2B
3295:CAMK2A
3285:CAMK1G
3280:CAMK1D
3275:CAMK1B
3270:CAMK1A
3124:PRKCB1
3061:PRKACA
3056:PRKACB
3051:PRKACG
3027:IKBKAP
2853:BCKDHB
2848:BCKDHA
2822:PRKAG3
2817:PRKAG2
2812:PRKAG1
2802:PRKAB2
2797:PRKAB1
2787:PRKAA2
2782:PRKAA1
2627:STK38L
2517:
2510:121427
2507:
2474:
2439:
2402:
2373:
2338:
2303:
2293:
2260:
2225:
2190:
2155:
2147:
2110:
2075:
2042:112412
2040:
2032:
1997:
1990:364685
1987:
1954:
1944:
1901:
1872:
1865:369532
1862:
1829:
1822:369523
1819:
1775:
1734:
1724:
1685:
1678:518784
1675:
1626:
1585:
1544:
1503:
1496:162206
1493:
1454:
1444:
1391:
1231:with:
1194:enzyme
1192:is an
1148:search
1146:PubMed
993:P18653
974:Q15418
866:Entrez
590:BioGPS
498:rectum
486:spleen
177:104558
169:601684
16:Enzyme
4570:Types
4326:MAP2K
4260:ACVR1
4253:BMPR2
4238:BMPR1
4163:GSK-3
4004:MAP3K
3965:MAPK9
3960:MAPK8
3938:MAPK7
3933:MAPK6
3928:MAPK4
3923:MAPK3
3918:MAPK1
3830:PFTK1
3825:PCTK3
3820:PCTK2
3815:PCTK1
3805:CDK12
3800:CDK10
3775:CDKL5
3755:CDKL2
3632:STK19
3627:EEF2K
3608:PHKG2
3603:PHKG1
3593:PHKA2
3588:PHKA1
3569:MYLK4
3564:MYLK3
3559:MYLK2
3535:DCLK1
3530:Titin
3520:TRIB3
3515:TRIB2
3510:TRIB1
3500:TSSK2
3480:STK40
3465:PSKH1
3460:PRKD3
3455:PRKD2
3435:PHKG2
3430:PHKG1
3420:OBSCN
3415:NUAK2
3410:NUAK1
3405:MKNK2
3400:MKNK1
3390:MARK4
3385:MARK3
3380:MARK2
3375:MARK1
3355:STK11
3350:DAPK3
3345:DAPK2
3340:DAPK1
3335:CHEK2
3330:CHEK1
3315:CAMK4
3290:CAMK2
3265:CAMK1
3260:BRSK2
3154:PRKCQ
3149:PRKCI
3144:PRKCG
3139:PRKCH
3134:PRKCE
3129:PRKCD
3090:PRKG1
3022:IKBKG
3017:IKBKE
2966:STK10
2961:FASTK
2887:IDH3G
2882:IDH3B
2877:IDH3A
2843:BCKDK
2637:ROCK1
2622:STK38
2617:MAST2
2612:MAST1
2607:LATS2
2602:LATS1
2153:S2CID
2055:Blood
2038:S2CID
1947:47899
1260:YWHAB
1256:, and
1243:MAPK1
899:20111
859:Mouse
854:Human
825:Amigo
548:ileum
466:blood
442:Mouse
435:Human
382:Start
317:Mouse
281:Start
214:Human
185:55703
4662:list
4655:EC7
4649:list
4642:EC6
4636:list
4629:EC5
4623:list
4616:EC4
4610:list
4603:EC3
4597:list
4590:EC2
4584:list
4577:EC1
4153:TPK1
4129:CDC7
4087:MLKs
4080:KSR2
4075:KSR1
4070:BRAF
4065:ARAF
4060:RAFs
3795:CDK9
3790:CDK8
3785:CDK7
3780:CDK6
3770:CDK5
3765:CDK4
3760:CDK3
3750:CDK2
3745:CDK1
3726:PLK4
3721:PLK3
3716:PLK2
3711:PLK1
3666:PLK4
3661:PLK3
3656:PLK2
3651:PLK1
3598:PHKB
3554:MYLK
3525:TRIO
3495:SPEG
3490:SNRK
3450:PKD1
3445:PIM2
3440:PIM1
3425:PASK
3395:MELK
3325:CASK
3320:MLCK
3241:GRK6
3236:GRK5
3231:GRK4
3169:PKN3
3164:PKN2
3066:PRKY
3012:TBK1
3007:IKK2
3002:CHUK
2906:STK4
2872:IDH2
2757:PDK4
2752:PDK3
2747:PDK2
2742:PDK1
2721:WEE1
2716:Wee1
2684:mTOR
2672:AKT3
2667:AKT2
2662:AKT1
2652:SGK3
2647:SGK2
2515:PMID
2472:PMID
2437:PMID
2400:PMID
2384:Gene
2371:PMID
2336:PMID
2301:PMID
2258:PMID
2223:PMID
2188:PMID
2170:Cell
2145:PMID
2108:PMID
2073:PMID
2030:PMID
2012:Cell
1995:PMID
1952:PMID
1899:PMID
1883:Gene
1870:PMID
1827:PMID
1773:PMID
1732:PMID
1683:PMID
1624:PMID
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1501:PMID
1452:PMID
1389:PMID
1254:TSC2
1249:TOB1
1237:IκBα
1217:MAPK
1201:gene
880:6195
425:Bgee
373:Band
334:Chr.
272:Band
231:Chr.
165:OMIM
122:5CSI
118:5CSN
114:5CSF
110:5CSJ
106:4NIF
102:4H3P
98:3RNY
94:2Z7S
90:2Z7R
86:2Z7Q
82:2WNT
63:RCSB
60:PDBe
4158:TTK
4122:ZAK
2699:HRI
2694:PKR
2642:SGK
2632:CIT
2505:PMC
2497:doi
2462:doi
2458:273
2429:doi
2417:278
2392:doi
2388:200
2361:doi
2357:272
2326:doi
2322:272
2291:PMC
2283:doi
2248:doi
2244:272
2213:doi
2209:271
2178:doi
2137:doi
2125:273
2098:doi
2094:271
2063:doi
2020:doi
1985:PMC
1977:doi
1942:PMC
1932:doi
1891:doi
1887:138
1860:PMC
1852:doi
1817:PMC
1809:doi
1763:doi
1759:278
1722:PMC
1714:doi
1710:388
1673:PMC
1663:doi
1651:101
1614:doi
1573:doi
1569:274
1532:doi
1528:278
1491:PMC
1483:doi
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