141:
118:
344:
147:
1306:
891:
constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of
154:
1027:
Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway".
597:
578:
79:
1379:
968:
1355:
950:
140:
818:
988:"Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases"
117:
1061:
937:
933:
59:
153:
900:
involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are
146:
1348:
642:
67:
1133:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
623:
1374:
1341:
1222:
1093:
46:
796:
775:
771:
737:
91:
1211:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
767:
763:
716:
712:
1284:
1250:
1197:
1162:
1119:
1040:
1009:
343:
39:
1325:
1274:
1240:
1230:
1187:
1152:
1144:
1109:
1101:
1032:
999:
233:
164:
108:
87:
893:
208:
1264:"Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B."
1176:"Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis"
1226:
1097:
1114:
1081:
897:
1245:
1210:
1157:
1132:
512:
507:
502:
497:
492:
487:
482:
477:
472:
456:
451:
446:
441:
436:
431:
415:
410:
405:
400:
395:
390:
385:
1368:
372:
71:
1317:
226:
95:
973:
National Center for
Biotechnology Information, U.S. National Library of Medicine
955:
National Center for
Biotechnology Information, U.S. National Library of Medicine
266:
125:
75:
1004:
987:
542:
192:
179:
83:
1288:
1279:
1263:
1254:
1235:
1201:
1166:
1123:
1044:
1013:
858:
853:
1192:
1175:
1036:
905:
842:
687:
668:
1105:
904:
nucleotide-binding sites (G1-G3). Transcript variants encoding distinct
1321:
1148:
901:
888:
874:
654:
609:
909:
826:
564:
1305:
986:
Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996).
527:
523:
1313:
881:
352:
63:
1209:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1262:
Sekiguchi T, Hirose E, Nakashima N, et al. (2001).
216:
1329:
1131:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1174:
Tomarev SI, Wistow G, Raymond V, et al. (2003).
333:
1080:
Ross MT, Grafham DV, Coffey AJ, et al. (2005).
912:responds to amino acids via interaction with RAGB.
789:
756:
730:
705:
297:
dentate gyrus of hippocampal formation granule cell
929:
927:
925:
163:
16:Protein-coding gene in the species Homo sapiens
1062:"Entrez Gene: RRAGB Ras-related GTP binding B"
934:GRCm38: Ensembl release 89: ENSMUSG00000041658
1349:
896:have in common the presence of six conserved
50:, RAGB, bA465E19.1, Ras related GTP binding B
8:
1082:"The DNA sequence of the human X chromosome"
1356:
1342:
538:
478:cellular response to amino acid starvation
368:
204:
103:
1278:
1244:
1234:
1191:
1156:
1113:
1003:
1056:
1054:
483:cellular response to amino acid stimulus
921:
508:cellular response to leucine starvation
503:positive regulation of TORC1 signaling
20:
168:
129:
124:
7:
1302:
1300:
488:positive regulation of TOR signaling
411:protein heterodimerization activity
1328:. You can help Knowledge (XXG) by
786:
753:
727:
702:
678:
659:
633:
614:
588:
569:
338:
261:
242:
221:
14:
877:that in humans is encoded by the
871:Ras-related GTP-binding protein B
1304:
342:
152:
145:
139:
116:
513:cellular response to starvation
353:More reference expression data
1:
1380:Human chromosome X gene stubs
401:guanyl ribonucleotide binding
137:
1215:Proc. Natl. Acad. Sci. U.S.A
1180:Invest. Ophthalmol. Vis. Sci
498:regulation of macroautophagy
473:regulation of TOR signaling
1396:
1299:
969:"Mouse PubMed Reference:"
951:"Human PubMed Reference:"
857:
852:
848:
841:
825:
819:Chr X: 151.92 – 151.95 Mb
808:
793:
760:
749:
734:
709:
698:
685:
681:
666:
662:
653:
640:
636:
621:
617:
608:
595:
591:
576:
572:
563:
548:
541:
537:
521:
371:
367:
350:
341:
332:
324:
273:
264:
249:
245:
215:
207:
203:
186:
173:
136:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1005:10.1074/jbc.270.48.28982
457:Gtr1-Gtr2 GTPase complex
1031:. 111. ( Pt 1): 11–21.
493:regulation of autophagy
1320:and/or its associated
1280:10.1074/jbc.M004389200
1236:10.1073/pnas.242603899
908:have been identified.
309:superior frontal gyrus
305:Cortex of frontal lobe
301:primary visual cortex
1193:10.1167/iovs.02-1099
1037:10.1242/jcs.111.1.11
131:X chromosome (mouse)
1227:2002PNAS...9916899M
1106:10.1038/nature03440
1098:2005Natur.434..325R
1312:This article on a
1149:10.1101/gr.2596504
643:ENSMUSG00000041658
466:Biological process
442:lysosomal membrane
425:Cellular component
386:nucleotide binding
379:Molecular function
281:hippocampus proper
1337:
1336:
1221:(26): 16899–903.
868:
867:
864:
863:
837:
836:
804:
803:
783:
782:
745:
744:
724:
723:
694:
693:
675:
674:
649:
648:
630:
629:
604:
603:
585:
584:
533:
532:
363:
362:
359:
358:
328:
327:
320:
319:
293:cerebellar cortex
258:
257:
199:
198:
96:RRAGB - orthologs
1387:
1358:
1351:
1344:
1308:
1301:
1292:
1282:
1258:
1248:
1238:
1205:
1195:
1170:
1160:
1127:
1117:
1092:(7031): 325–37.
1066:
1065:
1058:
1049:
1048:
1024:
1018:
1017:
1007:
983:
977:
976:
965:
959:
958:
947:
941:
931:
850:
849:
821:
814:
799:
787:
778:
754:
750:RefSeq (protein)
740:
728:
719:
703:
679:
660:
634:
615:
589:
570:
539:
369:
355:
346:
339:
269:
267:Top expressed in
262:
243:
222:
205:
195:
182:
171:
156:
149:
143:
132:
120:
104:
98:
49:
42:
21:
1395:
1394:
1390:
1389:
1388:
1386:
1385:
1384:
1365:
1364:
1363:
1362:
1297:
1295:
1273:(10): 7246–57.
1261:
1208:
1173:
1143:(10B): 2121–7.
1130:
1079:
1075:
1073:Further reading
1070:
1069:
1060:
1059:
1052:
1026:
1025:
1021:
998:(48): 28982–8.
985:
984:
980:
967:
966:
962:
949:
948:
944:
932:
923:
918:
894:Ras superfamily
887:Ras-homologous
859:View/Edit Mouse
854:View/Edit Human
817:
812:
809:Location (UCSC)
795:
774:
770:
766:
762:
736:
715:
711:
624:ENSG00000083750
517:
461:
420:
406:GTPase activity
396:protein binding
351:
316:
311:
307:
303:
299:
295:
291:
287:
283:
279:
265:
254:
190:
177:
169:
159:
158:
157:
150:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
1393:
1391:
1383:
1382:
1377:
1367:
1366:
1361:
1360:
1353:
1346:
1338:
1335:
1334:
1309:
1294:
1293:
1259:
1206:
1186:(6): 2588–96.
1171:
1128:
1076:
1074:
1071:
1068:
1067:
1050:
1019:
978:
960:
942:
920:
919:
917:
914:
866:
865:
862:
861:
856:
846:
845:
839:
838:
835:
834:
832:
830:
823:
822:
815:
810:
806:
805:
802:
801:
791:
790:
784:
781:
780:
758:
757:
751:
747:
746:
743:
742:
732:
731:
725:
722:
721:
707:
706:
700:
696:
695:
692:
691:
683:
682:
676:
673:
672:
664:
663:
657:
651:
650:
647:
646:
638:
637:
631:
628:
627:
619:
618:
612:
606:
605:
602:
601:
593:
592:
586:
583:
582:
574:
573:
567:
561:
560:
555:
550:
546:
545:
535:
534:
531:
530:
519:
518:
516:
515:
510:
505:
500:
495:
490:
485:
480:
475:
469:
467:
463:
462:
460:
459:
454:
449:
444:
439:
434:
428:
426:
422:
421:
419:
418:
416:GTPase binding
413:
408:
403:
398:
393:
388:
382:
380:
376:
375:
365:
364:
361:
360:
357:
356:
348:
347:
336:
330:
329:
326:
325:
322:
321:
318:
317:
315:
314:
313:olfactory bulb
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
271:
270:
259:
256:
255:
253:
250:
247:
246:
239:
238:
230:
219:
213:
212:
209:RNA expression
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1392:
1381:
1378:
1376:
1373:
1372:
1370:
1359:
1354:
1352:
1347:
1345:
1340:
1339:
1333:
1331:
1327:
1323:
1319:
1316:on the human
1315:
1310:
1307:
1303:
1298:
1290:
1286:
1281:
1276:
1272:
1268:
1267:J. Biol. Chem
1265:
1260:
1256:
1252:
1247:
1242:
1237:
1232:
1228:
1224:
1220:
1216:
1212:
1207:
1203:
1199:
1194:
1189:
1185:
1181:
1177:
1172:
1168:
1164:
1159:
1154:
1150:
1146:
1142:
1138:
1134:
1129:
1125:
1121:
1116:
1111:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1078:
1077:
1072:
1063:
1057:
1055:
1051:
1046:
1042:
1038:
1034:
1030:
1023:
1020:
1015:
1011:
1006:
1001:
997:
993:
989:
982:
979:
974:
970:
964:
961:
956:
952:
946:
943:
939:
935:
930:
928:
926:
922:
915:
913:
911:
907:
903:
899:
895:
890:
885:
883:
880:
876:
872:
860:
855:
851:
847:
844:
840:
833:
831:
828:
824:
820:
816:
811:
807:
800:
798:
792:
788:
785:
779:
777:
773:
769:
765:
759:
755:
752:
748:
741:
739:
733:
729:
726:
720:
718:
714:
708:
704:
701:
699:RefSeq (mRNA)
697:
690:
689:
684:
680:
677:
671:
670:
665:
661:
658:
656:
652:
645:
644:
639:
635:
632:
626:
625:
620:
616:
613:
611:
607:
600:
599:
594:
590:
587:
581:
580:
575:
571:
568:
566:
562:
559:
556:
554:
551:
547:
544:
540:
536:
529:
525:
520:
514:
511:
509:
506:
504:
501:
499:
496:
494:
491:
489:
486:
484:
481:
479:
476:
474:
471:
470:
468:
465:
464:
458:
455:
453:
450:
448:
445:
443:
440:
438:
435:
433:
430:
429:
427:
424:
423:
417:
414:
412:
409:
407:
404:
402:
399:
397:
394:
392:
389:
387:
384:
383:
381:
378:
377:
374:
373:Gene ontology
370:
366:
354:
349:
345:
340:
337:
335:
331:
323:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
275:
272:
268:
263:
260:
251:
248:
244:
241:
240:
237:
235:
231:
229:
228:
224:
223:
220:
218:
214:
210:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
1330:expanding it
1318:X chromosome
1311:
1296:
1270:
1266:
1218:
1214:
1183:
1179:
1140:
1136:
1089:
1085:
1028:
1022:
995:
991:
981:
972:
963:
954:
945:
886:
878:
870:
869:
797:NP_001004154
794:
776:NP_001340942
772:NP_001340940
761:
738:NM_001004154
735:
710:
686:
667:
641:
622:
596:
577:
557:
552:
277:hypothalamus
232:
225:
191:151,954,939
178:151,922,977
55:External IDs
18:
1375:Human genes
992:J Biol Chem
391:GTP binding
170:X|X F3
33:Identifiers
1369:Categories
1137:Genome Res
1029:J Cell Sci
940:, May 2017
916:References
285:cerebellum
236:(ortholog)
76:HomoloGene
768:NP_057740
764:NP_006055
717:NM_016656
713:NM_006064
543:Orthologs
432:cytoplasm
84:GeneCards
1289:11073942
1255:12477932
1202:12766061
1167:15489334
1124:15772651
936:–
906:isoforms
843:Wikidata
522:Sources:
447:lysosome
289:epiblast
1322:protein
1223:Bibcode
1115:2665286
1094:Bibcode
1045:9394008
1014:7499430
938:Ensembl
902:guanine
889:GTPases
875:protein
655:UniProt
610:Ensembl
549:Species
528:QuickGO
452:nucleus
437:cytosol
211:pattern
72:3038613
40:Aliases
1287:
1253:
1246:139241
1243:
1200:
1165:
1158:528928
1155:
1122:
1112:
1086:Nature
1043:
1012:
910:MTORC1
898:motifs
829:search
827:PubMed
688:Q6NTA4
669:Q5VZM2
598:245670
565:Entrez
334:BioGPS
64:300725
1324:is a
879:RRAGB
873:is a
579:10325
558:Mouse
553:Human
524:Amigo
234:Mouse
227:Human
174:Start
109:Mouse
88:RRAGB
80:48396
47:RRAGB
24:RRAGB
1326:stub
1314:gene
1285:PMID
1251:PMID
1198:PMID
1163:PMID
1120:PMID
1041:PMID
1010:PMID
892:the
882:gene
217:Bgee
165:Band
126:Chr.
60:OMIM
1275:doi
1271:276
1241:PMC
1231:doi
1188:doi
1153:PMC
1145:doi
1110:PMC
1102:doi
1090:434
1033:doi
1000:doi
996:270
813:n/a
252:n/a
187:End
92:OMA
68:MGI
1371::
1283:.
1269:.
1249:.
1239:.
1229:.
1219:99
1217:.
1213:.
1196:.
1184:44
1182:.
1178:.
1161:.
1151:.
1141:14
1139:.
1135:.
1118:.
1108:.
1100:.
1088:.
1084:.
1053:^
1039:.
1008:.
994:.
990:.
971:.
953:.
924:^
884:.
526:/
193:bp
180:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
1357:e
1350:t
1343:v
1332:.
1291:.
1277::
1257:.
1233::
1225::
1204:.
1190::
1169:.
1147::
1126:.
1104::
1096::
1064:.
1047:.
1035::
1016:.
1002::
975:.
957:.
111:)
94::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
