1183:
1199:
1211:
251:
228:
125:
150:
502:
257:
156:
1535:
1198:
1182:
1280:. The branches to the clades have pie charts, which give support values for the branches. The values are from right to left SH-aLRT/aBayes/UFBoot. The branches are considered supported when SH-aLRT ≥ 80%, aBayes ≥ 0.95, and UFBoot ≥ 95%. If a support value is above its threshold the pie chart is black otherwise gray.
1210:
1115:
like RGR-opsins. However only two of these introns are inserted at the same place, which still indicates that peropsins and RGR-opsins are more closely related to each other than to the ciliary and rhabdomeric opsins. This shared gene structure is also reflected in opsin phylogenies, where peropsins
1156:, also known as type 2 opsins). The other groups are the ciliary opsins (c-opsins, cilopsins), the rhabdomeric opsins (r-opsins, rhabopsins), the xenopsins, and the nessopsins. Four of these subclades occur in
2344:
Rivolta C, Berson EL, Dryja TP (December 2006). "Mutation screening of the peropsin gene, a retinal pigment epithelium specific rhodopsin homolog, in patients with retinitis pigmentosa and allied diseases".
1204:
Phylogenetic reconstruction of the tetraopsins. The outgroup contains other G protein-coupled receptors including the other opsins. The frame highlights the chromopsins, which are expanded in the next image.
1148:, the nemopsins, the astropsins, the varropsins, and the gluopsins. The chromopsins are one of three subgroups of the tetraopsins (also known as RGR/Go or Group 4 opsins). The other groups are the
1232:
contains sequences from opsins and other G protein-coupled receptors. The number of sequences and two pie charts are shown next to the clade. The first pie chart shows the percentage of a certain
1248:(R), dark and mid-gray for other amino acids, and light gray for sequences that have no data at that position. The second pie chart gives the taxon composition for each clade, green stands for
5422:
2676:
2248:
Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP (December 1999). "Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa".
1296:, which is like peropsin also expressed in the retinal pigment epithelium, peropsin was screened for a link with retinitis pigmentosa. However, no link could be established.
4888:
1216:
Phylogenetic reconstruction of the chromopsins. The outgroup contains other G protein-coupled receptors including the other opsins. The frame highlights the peropsins.
264:
163:
3826:
4028:
4023:
4018:
4013:
1996:
Bailey MJ, Cassone VM (March 2004). "Opsin photoisomerases in the chick retina and pineal gland: characterization, localization, and circadian regulation".
4758:
5148:
5143:
2371:
720:
701:
86:
5179:
4524:
2669:
5139:
3925:
3920:
5163:
4845:
4840:
4835:
3801:
5219:
4089:
3916:
2403:
4830:
3776:
1373:
1355:
1236:
at the position in the sequences corresponding to position 296 in cattle rhodopsin. The amino acids are color-coded. The colors are red for
5588:
5583:
4004:
3816:
3286:
3024:
3019:
3014:
3009:
3004:
2662:
4817:
3466:
920:
250:
4722:
3691:
1289:
1141:
927:
5391:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
3579:
3374:
3369:
3364:
3000:
227:
1462:
5173:
5168:
4108:
4103:
3184:
3179:
5352:
5259:
4113:
3359:
3114:
1342:
1321:
5208:
5203:
4737:
3978:
3973:
3821:
3670:
3665:
1338:
149:
124:
4742:
1317:
1051:
instead of 11-cis-retinal, as it is in cattle rhodopsin. Therefore, peropsins have been suggested to be photoisomerases.
5199:
3539:
3534:
2770:
2765:
2760:
2750:
2745:
2740:
66:
4733:
3300:
3295:
2756:
2736:
2633:
1614:"Amphioxus homologs of Go-coupled rhodopsin and peropsin having 11-cis- and all-trans-retinals as their chromophores"
3733:
3728:
3584:
3574:
3569:
3554:
3549:
3522:
3348:
3343:
3338:
3249:
2786:
2781:
2776:
2689:
2396:
2038:"In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution"
1189:
1064:
998:
263:
162:
1400:"Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium"
3770:
3765:
3760:
3530:
3416:
3244:
3226:
3207:
3200:
2719:
2296:"RRH, encoding the RPE-expressed opsin-like peropsin, is not mutated in retinitis pigmentosa and allied diseases"
2295:
1140:
and with them humans. The peropsins are one of the seven subgroups of the chromopsins. The other groups are the
256:
155:
5325:
5194:
5154:
4800:
3724:
3686:
3545:
3334:
3258:
3212:
2702:
765:
74:
4058:
4053:
4048:
4043:
4038:
3998:
3993:
3910:
3905:
3900:
3890:
3756:
3640:
3608:
3603:
3565:
3560:
3471:
3195:
2438:
746:
3711:
3706:
3623:
3618:
3217:
2818:
2813:
5256:
4094:
4078:
4073:
4068:
4034:
3989:
3886:
3749:
3744:
3696:
3599:
3594:
3381:
3265:
3108:
3103:
3098:
3087:
3082:
3077:
3072:
2823:
2808:
2685:
2582:
2547:
2389:
1949:"Expression of peropsin in human skin is related to phototransduction of violet light in keratinocytes"
5306:
4964:
4276:
4099:
4084:
3950:
3945:
3940:
3661:
3614:
3291:
3270:
3055:
3050:
3045:
3040:
3035:
2654:
2428:
2204:
1850:
1723:
1674:
1565:
1411:
1293:
1018:
138:
53:
22:
2092:
Ramirez MD, Pairett AN, Pankey MS, Serb JM, Speiser DI, Swafford AJ, et al. (26 October 2016).
5129:
4064:
3955:
3739:
3702:
3167:
2796:
2728:
2601:
2551:
1145:
5348:
4859:
4683:
3795:
3790:
3785:
3719:
3094:
3067:
2804:
2326:
2273:
1978:
1692:
1643:
98:
2191:
Liegertová M, Pergner J, Kozmiková I, Fabian P, Pombinho AR, Strnad H, et al. (July 2015).
1810:
Oroshnik W (June 1956). "The
Synthesis and Configuration of Neo-B Vitamin A and Neoretinine b".
903:
882:
856:
835:
5214:
5158:
4804:
4534:
4529:
3984:
3681:
3030:
2354:
2318:
2265:
2230:
2193:"Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution"
2173:
2121:
2069:
2013:
1970:
1929:
1878:
1792:
1751:
1635:
1591:
1524:
1439:
46:
4009:
3931:
3781:
2643:
2556:
2532:
2310:
2257:
2220:
2212:
2163:
2155:
2142:
Porter ML, Blasic JR, Bok MJ, Cameron EG, Pringle T, Cronin TW, et al. (January 2012).
2111:
2101:
2059:
2049:
2005:
1960:
1919:
1909:
1868:
1858:
1819:
1782:
1741:
1731:
1682:
1625:
1581:
1573:
1514:
1504:
1429:
1419:
343:
274:
218:
173:
2606:
5402:
5189:
4998:
4287:
3969:
3936:
3676:
2973:
2958:
2953:
2948:
2938:
2933:
2928:
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2918:
1253:
1044:
318:
94:
2208:
1854:
1727:
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1569:
1415:
501:
5275:
4135:
3963:
3190:
2983:
2978:
2968:
2944:
2914:
2909:
2225:
2192:
2168:
2143:
2116:
2093:
1947:
Toh PP, Bigliardi-Qi M, Yap AM, Sriram G, Stelmashenko O, Bigliardi P (December 2016).
1924:
1897:
1586:
1553:
1519:
1492:
2064:
2037:
1873:
1838:
1787:
1770:
1746:
1711:
1630:
1613:
635:
630:
625:
620:
615:
610:
605:
589:
584:
579:
574:
558:
553:
543:
5577:
5330:
4979:
4974:
4969:
3895:
3831:
2899:
2375:
1896:
Cook JD, Ng SY, Lloyd M, Eddington S, Sun H, Nathans J, et al. (December 2017).
1552:
Leung NY, Thakur DP, Gurav AS, Kim SH, Di Pizio A, Niv MY, et al. (April 2020).
1434:
1399:
1241:
530:
2277:
1647:
78:
5252:
3650:
3644:
3254:
3239:
3062:
2829:
1982:
1898:"Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium"
1839:"Hindered Cis Isomers of Vitamin A and Retinene: The Structure of the Neo-B Isomer"
1712:"Hindered Cis Isomers of Vitamin A and Retinene: The Structure of the Neo-B Isomer"
1696:
1096:
1084:
1076:
336:
115:
2330:
1152:
and the Go-opsins. The tetraopsins are one of the five major groups of the animal
2094:"The last common ancestor of most bilaterian animals possessed at least 9 opsins"
102:
1378:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1360:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1088:
1843:
Proceedings of the
National Academy of Sciences of the United States of America
1716:
Proceedings of the
National Academy of Sciences of the United States of America
1539:
1404:
Proceedings of the
National Academy of Sciences of the United States of America
419:
5554:
5470:
4697:
2524:
2510:
2490:
2451:
2314:
1577:
1257:
1233:
1108:
1060:
1026:
235:
132:
82:
1538:
Material was copied and adapted from this source, which is available under a
1192:. The frame highlights the tetraopsins, which are expanded in the next image.
5263:
5184:
2706:
2638:
2446:
2412:
1914:
1424:
1277:
1269:
1225:
1165:
1161:
1157:
1068:
1040:
1033:
665:
548:
479:
357:
302:
289:
201:
188:
90:
2358:
2322:
2269:
2234:
2177:
2159:
2125:
2073:
2017:
1974:
1933:
1882:
1796:
1755:
1639:
1595:
1528:
2054:
1863:
1736:
1509:
1443:
967:
962:
5488:
5466:
2628:
2106:
2009:
1261:
1249:
1245:
1129:
1125:
951:
810:
791:
1823:
1398:
Sun H, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (September 1997).
4559:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4234:
4229:
4224:
4219:
4214:
4209:
4204:
4199:
4194:
4189:
4184:
3880:
3875:
3870:
3865:
2465:
2415:
1534:
1463:"Entrez Gene: RRH retinal pigment epithelium-derived rhodopsin homolog"
1273:
1265:
1188:
Phylogenetic reconstruction of the opsins. The outgroup contains other
1092:
1048:
983:
777:
732:
2216:
1965:
1948:
1160:(all but the nessopsins). However, the bilaterian clades constitute a
5441:
5436:
5431:
5426:
5416:
5411:
5406:
5397:
5342:
5337:
5299:
5294:
5289:
5134:
5110:
5105:
5100:
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4707:
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4154:
4149:
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3324:
3318:
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2461:
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1237:
1137:
1112:
1072:
1030:
1022:
1006:
935:
687:
2294:
Ksantini M, Sénéchal A, Humbert G, Arnaud B, Hamel CP (March 2007).
5537:
5228:
5223:
5025:
5020:
5015:
5010:
4986:
4932:
4927:
4922:
4767:
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4424:
4419:
4414:
4409:
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4399:
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4369:
4364:
4359:
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4339:
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4329:
4324:
4319:
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3655:
3495:
3490:
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3475:
3461:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3410:
3405:
3400:
3395:
3390:
3385:
3353:
3313:
3308:
3231:
3143:
3138:
3133:
3128:
3123:
3118:
2878:
2863:
2858:
2853:
2848:
2843:
2838:
2833:
2611:
2596:
2591:
2586:
2541:
2536:
2482:
2423:
2261:
1229:
1173:
The phylogenetic relationship of the peropsins to the other opsins
1153:
1133:
994:
650:
646:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5492:
4910:
4903:
4898:
4893:
4702:
4692:
4314:
4309:
4304:
4299:
3959:
3835:
3329:
2500:
2495:
1612:
Koyanagi M, Terakita A, Kubokawa K, Shichida Y (November 2002).
1149:
1080:
1002:
990:
510:
70:
5463:
5250:
4798:
2700:
2658:
2385:
2381:
1036:, which is important for retinal binding and light sensing.
1837:
Oroshnik W, Brown PK, Hubbard R, Wald G (September 1956).
1493:"The Gluopsins: Opsins without the Retinal Binding Lysine"
1001:. Even so, the first peropsins were already discovered in
326:
1116:
and RGR-opsins are in the same group: The chromopsins.
1540:
Creative
Commons Attribution 4.0 International License
1067:(RPE). There, it regulates storage or the movement of
57:, retinal pigment epithelium-derived rhodopsin homolog
1710:
Wald G, Brown PK, Hubbard R, Oroshnik W (July 1955).
491:
5547:
5481:
5316:
5274:
5120:
4997:
4816:
4669:
4286:
4134:
4127:
3633:
3521:
3514:
3279:
3166:
3157:
2993:
2898:
2795:
2727:
2718:
2621:
2523:
2481:
2437:
2422:
1095:, a peropsin is expressed with an RGR-opsin in the
896:
875:
849:
828:
2036:Bellingham J, Wells DJ, Foster RG (January 2003).
1334:
1332:
1330:
1313:
1311:
1309:
2031:
2029:
2027:
273:
172:
1998:Investigative Ophthalmology & Visual Science
1017:Like most opsins, peropsins have in its seventh
2289:
2287:
1663:"Carotenoids and the Vitamin A Cycle in Vision"
1059:In mice, a peropsin is localized to the apical
1047:, a peropsin binds in the dark-state all-trans-
16:Protein-coding gene in the species Homo sapiens
2137:
2135:
2087:
2085:
2083:
1607:
1605:
1486:
1484:
1482:
1480:
1478:
1476:
1474:
1472:
1339:GRCm38: Ensembl release 89: ENSMUSG00000028012
2670:
2397:
8:
1771:"The neo-b isomer of vitamin A and retinene"
1491:Gühmann M, Porter ML, Bok MJ (August 2022).
1075:to the RPE. A peropsin is also expressed in
621:G protein-coupled receptor signaling pathway
1318:GRCh38: Ensembl release 89: ENSG00000180245
5478:
5460:
5271:
5247:
4813:
4795:
4131:
3518:
3163:
2724:
2715:
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2677:
2663:
2655:
2434:
2404:
2390:
2382:
2372:United States National Library of Medicine
661:
526:
314:
213:
110:
2224:
2167:
2115:
2105:
2063:
2053:
1964:
1923:
1913:
1872:
1862:
1786:
1745:
1735:
1686:
1629:
1585:
1554:"Functions of Opsins in Drosophila Taste"
1518:
1508:
1433:
1423:
1393:
1391:
1389:
1387:
2370:This article incorporates text from the
1812:Journal of the American Chemical Society
1457:
1455:
1453:
559:G protein-coupled photoreceptor activity
2144:"Shedding new light on opsin evolution"
1305:
1178:
1009:in 1997, not much is known about them.
982:, a visual pigment-like receptor, is a
3827:Luteinizing hormone/choriogonadotropin
27:
4831:Brain-specific angiogenesis inhibitor
580:integral component of plasma membrane
278:
239:
234:
177:
136:
131:
7:
1124:The peropsins are restricted to the
1902:The Journal of Biological Chemistry
1775:The Journal of Biological Chemistry
636:cellular response to light stimulus
554:G protein-coupled receptor activity
1164:taxon without the opsins from the
893:
872:
846:
825:
801:
782:
756:
737:
711:
692:
496:
414:
352:
331:
14:
1769:Brown PK, Wald G (October 1956).
986:that in humans is encoded by the
5180:Growth-hormone-releasing hormone
2148:Proceedings. Biological Sciences
1533:
1209:
1197:
1181:
1107:The human peropsin gene lies on
500:
262:
255:
249:
226:
161:
154:
148:
123:
5140:Corticotropin-releasing hormone
1103:Gene localization and structure
993:. It belongs like other animal
3802:Gonadotropin-releasing hormone
1128:and the cephalochordates. The
575:integral component of membrane
511:More reference expression data
480:More reference expression data
384:right hemisphere of cerebellum
1:
5220:Vasoactive intestinal peptide
4090:Thyrotropin-releasing hormone
1788:10.1016/S0021-9258(20)89944-X
1631:10.1016/s0014-5793(02)03616-5
247:
146:
2098:Genome Biology and Evolution
466:Epithelium of choroid plexus
5589:G protein-coupled receptors
5584:Genes on human chromosome 4
4005:Prolactin-releasing peptide
2690:G protein-coupled receptors
2634:Guanylate cyclase activator
1190:G protein-coupled receptors
1091:if retinal is supplied. In
999:G protein-coupled receptors
590:photoreceptor outer segment
396:stromal cell of endometrium
5605:
1065:retinal pigment epithelium
631:detection of visible light
549:signal transducer activity
430:retinal pigment epithelium
372:retinal pigment epithelium
20:
5477:
5459:
5270:
5246:
4812:
4794:
2714:
2696:
2315:10.1080/13816810701202052
1578:10.1016/j.cub.2020.01.068
1374:"Mouse PubMed Reference:"
1356:"Human PubMed Reference:"
966:
961:
957:
950:
934:
921:Chr 4: 109.83 – 109.85 Mb
915:
900:
879:
868:
853:
832:
821:
808:
804:
789:
785:
776:
763:
759:
744:
740:
731:
718:
714:
699:
695:
686:
671:
664:
660:
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195:
182:
145:
122:
113:
109:
64:
61:
51:
44:
39:
35:
30:
5326:Calcium-sensing receptor
5195:Methuselah-like proteins
1953:Experimental Dermatology
1111:4 band 4q25 and has six
928:Chr 3: 129.6 – 129.62 Mb
3472:Sphingosine-1-phosphate
3360:Hydroxycarboxylic acids
1915:10.1074/jbc.M117.812701
1425:10.1073/pnas.94.18.9893
1292:may be associated with
404:developmental structure
5353:Metabotropic glutamate
2160:10.1098/rspb.2011.1819
544:photoreceptor activity
434:neural layer of retina
3382:Lysophosphatidic acid
2686:Cell surface receptor
2055:10.1186/1471-2164-4-3
1864:10.1073/pnas.42.9.578
1737:10.1073/pnas.41.7.438
1510:10.3390/cells11152441
1284:Clinical significance
380:cerebellar hemisphere
5307:Vomeronasal receptor
4277:Vomeronasal receptor
2429:retinylidene protein
2010:10.1167/iovs.03-1125
1661:Wald G (July 1934).
1294:retinitis pigmentosa
1019:transmembrane domain
611:response to stimulus
280:3 G3|3 59.09 cM
241:Chromosome 3 (mouse)
139:Chromosome 4 (human)
23:RRH (disambiguation)
21:For other uses, see
5200:Parathyroid hormone
3160:signaling molecules
2303:Ophthalmic Genetics
2209:2015NatSR...511885L
1908:(52): 21407–21416.
1855:1956PNAS...42..578O
1824:10.1021/ja01592a095
1728:1955PNAS...41..438W
1679:1934Natur.134...65W
1570:2020CBio...30E1367L
1564:(8): 1367–1379.e6.
1416:1997PNAS...94.9893S
1055:Tissue localization
606:signal transduction
5349:Glutamate receptor
4734:Protease-activated
2374:, which is in the
2197:Scientific Reports
2107:10.1093/gbe/evw248
1083:. In keratinocyte
766:ENSMUSG00000028012
599:Biological process
568:Cellular component
537:Molecular function
5571:
5570:
5567:
5566:
5563:
5562:
5455:
5454:
5451:
5450:
5242:
5241:
5238:
5237:
4790:
4789:
4786:
4785:
4782:
4781:
4123:
4122:
3510:
3509:
3153:
3152:
2652:
2651:
2519:
2518:
2217:10.1038/srep11885
1966:10.1111/exd.13226
1959:(12): 1002–1005.
1818:(11): 2651–2652.
1410:(18): 9893–9898.
1276:, and purple for
1272:, light blue for
1252:, dark green for
1025:corresponding to
977:
976:
973:
972:
946:
945:
911:
910:
890:
889:
864:
863:
843:
842:
817:
816:
798:
797:
772:
771:
753:
752:
727:
726:
708:
707:
656:
655:
626:phototransduction
616:visual perception
521:
520:
517:
516:
486:
485:
473:
472:
411:
410:
388:prefrontal cortex
376:cerebellar cortex
309:
308:
208:
207:
5596:
5479:
5461:
5272:
5248:
4814:
4796:
4132:
3519:
3417:Lysophospholipid
3164:
2725:
2720:Neurotransmitter
2716:
2698:
2679:
2672:
2665:
2656:
2644:Rhodopsin kinase
2435:
2406:
2399:
2392:
2383:
2363:
2362:
2347:Molecular Vision
2341:
2335:
2334:
2300:
2291:
2282:
2281:
2245:
2239:
2238:
2228:
2188:
2182:
2181:
2171:
2139:
2130:
2129:
2119:
2109:
2089:
2078:
2077:
2067:
2057:
2033:
2022:
2021:
1993:
1987:
1986:
1968:
1944:
1938:
1937:
1927:
1917:
1893:
1887:
1886:
1876:
1866:
1834:
1828:
1827:
1807:
1801:
1800:
1790:
1766:
1760:
1759:
1749:
1739:
1707:
1701:
1700:
1690:
1688:10.1038/134065a0
1658:
1652:
1651:
1633:
1609:
1600:
1599:
1589:
1549:
1543:
1537:
1532:
1522:
1512:
1488:
1467:
1466:
1459:
1448:
1447:
1437:
1427:
1395:
1382:
1381:
1370:
1364:
1363:
1352:
1346:
1336:
1325:
1315:
1268:, dark blue for
1264:, pale pink for
1256:, mid green for
1254:cephalochordates
1244:(E), orange for
1240:(K), purple for
1213:
1201:
1185:
1099:and the retina.
1029:position 296 in
959:
958:
930:
923:
906:
894:
885:
873:
869:RefSeq (protein)
859:
847:
838:
826:
802:
783:
757:
738:
712:
693:
662:
527:
513:
504:
497:
482:
442:secondary oocyte
422:
420:Top expressed in
415:
360:
358:Top expressed in
353:
332:
315:
305:
292:
281:
266:
259:
253:
242:
230:
214:
204:
191:
180:
165:
158:
152:
141:
127:
111:
105:
56:
49:
28:
5604:
5603:
5599:
5598:
5597:
5595:
5594:
5593:
5574:
5573:
5572:
5559:
5543:
5473:
5447:
5334:
5312:
5266:
5234:
5116:
4993:
4808:
4778:
4665:
4282:
4119:
3725:Cholecystokinin
3629:
3506:
3335:Free fatty acid
3275:
3159:
3158:Metabolites and
3149:
2989:
2894:
2791:
2710:
2692:
2683:
2653:
2648:
2617:
2515:
2477:
2426:
2418:
2410:
2367:
2366:
2343:
2342:
2338:
2298:
2293:
2292:
2285:
2250:Nature Genetics
2247:
2246:
2242:
2190:
2189:
2185:
2141:
2140:
2133:
2091:
2090:
2081:
2035:
2034:
2025:
1995:
1994:
1990:
1946:
1945:
1941:
1895:
1894:
1890:
1836:
1835:
1831:
1809:
1808:
1804:
1768:
1767:
1763:
1709:
1708:
1704:
1660:
1659:
1655:
1611:
1610:
1603:
1558:Current Biology
1551:
1550:
1546:
1490:
1489:
1470:
1461:
1460:
1451:
1397:
1396:
1385:
1372:
1371:
1367:
1354:
1353:
1349:
1337:
1328:
1316:
1307:
1302:
1286:
1222:
1221:
1220:
1217:
1214:
1205:
1202:
1193:
1186:
1175:
1174:
1122:
1105:
1087:, it reacts to
1057:
1045:cephalochordate
1015:
968:View/Edit Mouse
963:View/Edit Human
926:
919:
916:Location (UCSC)
902:
881:
855:
834:
747:ENSG00000180245
640:
594:
563:
509:
478:
469:
464:
460:
456:
452:
448:
444:
440:
436:
432:
418:
407:
402:
400:Brodmann area 9
398:
394:
392:Achilles tendon
390:
386:
382:
378:
374:
370:
356:
300:
287:
279:
269:
268:
267:
260:
240:
217:Gene location (
199:
186:
178:
168:
167:
166:
159:
137:
114:Gene location (
103:RRH - orthologs
65:
52:
45:
26:
17:
12:
11:
5:
5602:
5600:
5592:
5591:
5586:
5576:
5575:
5569:
5568:
5565:
5564:
5561:
5560:
5558:
5557:
5551:
5549:
5545:
5544:
5542:
5541:
5535:
5530:
5525:
5520:
5515:
5510:
5505:
5500:
5495:
5485:
5483:
5475:
5474:
5464:
5457:
5456:
5453:
5452:
5449:
5448:
5446:
5445:
5439:
5434:
5429:
5420:
5414:
5409:
5400:
5395:
5389:
5384:
5379:
5374:
5369:
5364:
5359:
5346:
5340:
5332:
5328:
5322:
5320:
5314:
5313:
5311:
5310:
5304:
5303:
5302:
5297:
5292:
5281:
5279:
5268:
5267:
5251:
5244:
5243:
5240:
5239:
5236:
5235:
5233:
5232:
5226:
5217:
5212:
5206:
5197:
5192:
5187:
5182:
5177:
5171:
5166:
5161:
5152:
5146:
5137:
5132:
5126:
5124:
5118:
5117:
5115:
5114:
5108:
5103:
5098:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5003:
5001:
4995:
4994:
4992:
4991:
4990:
4989:
4984:
4983:
4982:
4977:
4972:
4957:
4956:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4915:
4914:
4913:
4908:
4907:
4906:
4901:
4896:
4881:
4880:
4879:
4878:
4877:
4872:
4867:
4852:
4851:
4850:
4849:
4848:
4843:
4838:
4822:
4820:
4810:
4809:
4799:
4792:
4791:
4788:
4787:
4784:
4783:
4780:
4779:
4777:
4776:
4770:
4765:
4756:
4750:
4745:
4740:
4731:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4686:
4681:
4679:Adrenomedullin
4675:
4673:
4667:
4666:
4664:
4663:
4657:
4652:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4292:
4290:
4284:
4283:
4281:
4280:
4274:
4273:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4141:
4139:
4129:
4125:
4124:
4121:
4120:
4118:
4117:
4111:
4106:
4097:
4092:
4087:
4082:
4076:
4071:
4062:
4056:
4051:
4046:
4041:
4032:
4026:
4021:
4016:
4007:
4002:
3996:
3987:
3982:
3976:
3967:
3953:
3948:
3943:
3934:
3929:
3923:
3914:
3908:
3903:
3898:
3893:
3884:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3829:
3824:
3819:
3814:
3808:
3799:
3793:
3788:
3779:
3774:
3768:
3763:
3757:Formyl peptide
3754:
3753:
3752:
3747:
3737:
3731:
3722:
3717:
3716:
3715:
3709:
3700:
3694:
3689:
3679:
3674:
3668:
3659:
3653:
3647:
3637:
3635:
3631:
3630:
3628:
3627:
3621:
3612:
3606:
3597:
3588:
3582:
3577:
3572:
3563:
3558:
3552:
3543:
3537:
3527:
3525:
3516:
3512:
3511:
3508:
3507:
3505:
3504:
3499:
3493:
3488:
3483:
3478:
3469:
3464:
3459:
3453:
3448:
3443:
3438:
3433:
3428:
3423:
3414:
3408:
3403:
3398:
3393:
3388:
3379:
3378:
3377:
3372:
3367:
3357:
3351:
3346:
3341:
3332:
3327:
3322:
3316:
3311:
3298:
3289:
3283:
3281:
3277:
3276:
3274:
3273:
3268:
3263:
3262:
3261:
3252:
3247:
3242:
3229:
3215:
3210:
3205:
3204:
3203:
3198:
3188:
3182:
3172:
3170:
3161:
3155:
3154:
3151:
3150:
3148:
3147:
3141:
3136:
3131:
3126:
3121:
3112:
3106:
3101:
3092:
3091:
3090:
3085:
3080:
3075:
3065:
3060:
3059:
3058:
3053:
3048:
3043:
3038:
3028:
3022:
3017:
3012:
3007:
2997:
2995:
2991:
2990:
2988:
2987:
2981:
2976:
2971:
2962:
2956:
2951:
2942:
2936:
2931:
2926:
2921:
2904:
2902:
2896:
2895:
2893:
2892:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2827:
2821:
2816:
2811:
2801:
2799:
2793:
2792:
2790:
2789:
2784:
2779:
2774:
2768:
2763:
2754:
2748:
2743:
2733:
2731:
2722:
2712:
2711:
2701:
2694:
2693:
2684:
2682:
2681:
2674:
2667:
2659:
2650:
2649:
2647:
2646:
2641:
2636:
2631:
2625:
2623:
2619:
2618:
2616:
2615:
2609:
2604:
2599:
2594:
2589:
2580:
2574:
2569:
2564:
2559:
2554:
2545:
2539:
2529:
2527:
2521:
2520:
2517:
2516:
2514:
2513:
2508:
2503:
2498:
2493:
2487:
2485:
2479:
2478:
2476:
2475:
2474:
2473:
2468:
2459:
2449:
2443:
2441:
2432:
2420:
2419:
2411:
2409:
2408:
2401:
2394:
2386:
2365:
2364:
2336:
2283:
2256:(4): 393–394.
2240:
2183:
2154:(1726): 3–14.
2131:
2079:
2023:
2004:(3): 769–775.
1988:
1939:
1888:
1849:(9): 578–580.
1829:
1802:
1781:(2): 865–877.
1761:
1722:(7): 438–451.
1702:
1653:
1624:(3): 525–528.
1601:
1544:
1468:
1449:
1383:
1365:
1347:
1326:
1304:
1303:
1301:
1298:
1285:
1282:
1219:
1218:
1215:
1208:
1206:
1203:
1196:
1194:
1187:
1180:
1177:
1176:
1172:
1171:
1170:
1136:that contains
1121:
1118:
1104:
1101:
1056:
1053:
1014:
1013:Photochemistry
1011:
975:
974:
971:
970:
965:
955:
954:
948:
947:
944:
943:
941:
939:
932:
931:
924:
917:
913:
912:
909:
908:
898:
897:
891:
888:
887:
877:
876:
870:
866:
865:
862:
861:
851:
850:
844:
841:
840:
830:
829:
823:
819:
818:
815:
814:
806:
805:
799:
796:
795:
787:
786:
780:
774:
773:
770:
769:
761:
760:
754:
751:
750:
742:
741:
735:
729:
728:
725:
724:
716:
715:
709:
706:
705:
697:
696:
690:
684:
683:
678:
673:
669:
668:
658:
657:
654:
653:
642:
641:
639:
638:
633:
628:
623:
618:
613:
608:
602:
600:
596:
595:
593:
592:
587:
582:
577:
571:
569:
565:
564:
562:
561:
556:
551:
546:
540:
538:
534:
533:
523:
522:
519:
518:
515:
514:
506:
505:
494:
488:
487:
484:
483:
475:
474:
471:
470:
468:
467:
463:
459:
455:
451:
447:
446:primary oocyte
443:
439:
435:
431:
427:
424:
423:
412:
409:
408:
406:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
362:
361:
349:
348:
340:
329:
323:
322:
319:RNA expression
311:
310:
307:
306:
298:
294:
293:
285:
282:
277:
271:
270:
261:
254:
248:
244:
243:
238:
232:
231:
223:
222:
210:
209:
206:
205:
197:
193:
192:
184:
181:
176:
170:
169:
160:
153:
147:
143:
142:
135:
129:
128:
120:
119:
107:
106:
63:
59:
58:
50:
42:
41:
37:
36:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
5601:
5590:
5587:
5585:
5582:
5581:
5579:
5556:
5553:
5552:
5550:
5546:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5490:
5487:
5486:
5484:
5480:
5476:
5472:
5468:
5462:
5458:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5424:
5421:
5418:
5415:
5413:
5410:
5408:
5404:
5401:
5399:
5396:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5358:
5354:
5350:
5347:
5344:
5341:
5339:
5335:
5329:
5327:
5324:
5323:
5321:
5319:
5315:
5308:
5305:
5301:
5298:
5296:
5293:
5291:
5288:
5287:
5286:
5283:
5282:
5280:
5277:
5273:
5269:
5265:
5261:
5258:
5254:
5249:
5245:
5230:
5227:
5225:
5221:
5218:
5216:
5213:
5210:
5207:
5205:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5156:
5153:
5150:
5147:
5145:
5141:
5138:
5136:
5133:
5131:
5128:
5127:
5125:
5123:
5119:
5112:
5109:
5107:
5104:
5102:
5099:
5097:
5094:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5008:
5005:
5004:
5002:
5000:
4996:
4988:
4985:
4981:
4978:
4976:
4973:
4971:
4968:
4967:
4966:
4963:
4962:
4961:
4958:
4954:
4951:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4920:
4919:
4916:
4912:
4909:
4905:
4902:
4900:
4897:
4895:
4892:
4891:
4890:
4887:
4886:
4885:
4882:
4876:
4873:
4871:
4868:
4866:
4863:
4862:
4861:
4858:
4857:
4856:
4853:
4847:
4844:
4842:
4839:
4837:
4834:
4833:
4832:
4829:
4828:
4827:
4824:
4823:
4821:
4819:
4815:
4811:
4806:
4802:
4797:
4793:
4774:
4771:
4769:
4766:
4764:
4760:
4757:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4735:
4732:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4690:
4687:
4685:
4682:
4680:
4677:
4676:
4674:
4672:
4668:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4297:
4294:
4293:
4291:
4289:
4285:
4278:
4275:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4147:
4146:
4143:
4142:
4140:
4137:
4133:
4130:
4128:Miscellaneous
4126:
4115:
4112:
4110:
4107:
4105:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4080:
4077:
4075:
4072:
4070:
4066:
4063:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4036:
4033:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4011:
4008:
4006:
4003:
4000:
3997:
3995:
3991:
3988:
3986:
3983:
3980:
3977:
3975:
3971:
3968:
3965:
3961:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3938:
3935:
3933:
3930:
3927:
3924:
3922:
3918:
3915:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3888:
3885:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3812:
3809:
3807:
3803:
3800:
3797:
3794:
3792:
3789:
3787:
3783:
3780:
3778:
3775:
3772:
3769:
3767:
3764:
3762:
3758:
3755:
3751:
3748:
3746:
3743:
3742:
3741:
3738:
3735:
3732:
3730:
3726:
3723:
3721:
3718:
3713:
3710:
3708:
3704:
3701:
3698:
3695:
3693:
3690:
3688:
3685:
3684:
3683:
3680:
3678:
3675:
3672:
3669:
3667:
3663:
3660:
3657:
3654:
3652:
3648:
3646:
3642:
3641:Anaphylatoxin
3639:
3638:
3636:
3632:
3625:
3622:
3620:
3616:
3613:
3610:
3607:
3605:
3601:
3598:
3596:
3592:
3589:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3567:
3564:
3562:
3559:
3556:
3553:
3551:
3547:
3544:
3541:
3538:
3536:
3532:
3529:
3528:
3526:
3524:
3520:
3517:
3513:
3503:
3500:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3473:
3470:
3468:
3465:
3463:
3460:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3418:
3415:
3412:
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3383:
3380:
3376:
3373:
3371:
3368:
3366:
3363:
3362:
3361:
3358:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3336:
3333:
3331:
3328:
3326:
3323:
3320:
3317:
3315:
3312:
3310:
3306:
3302:
3299:
3297:
3293:
3290:
3288:
3285:
3284:
3282:
3278:
3272:
3269:
3267:
3264:
3260:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3237:
3233:
3230:
3228:
3224:
3221:
3220:
3219:
3218:Prostaglandin
3216:
3214:
3211:
3209:
3206:
3202:
3199:
3197:
3194:
3193:
3192:
3189:
3186:
3183:
3181:
3177:
3174:
3173:
3171:
3169:
3165:
3162:
3156:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3116:
3113:
3110:
3107:
3105:
3102:
3100:
3096:
3093:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3070:
3069:
3066:
3064:
3061:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3033:
3032:
3029:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3002:
3001:Acetylcholine
2999:
2998:
2996:
2992:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2966:
2963:
2960:
2957:
2955:
2952:
2950:
2946:
2943:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2916:
2913:
2911:
2906:
2905:
2903:
2901:
2897:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2831:
2828:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2806:
2803:
2802:
2800:
2798:
2794:
2788:
2785:
2783:
2780:
2778:
2775:
2772:
2769:
2767:
2764:
2762:
2758:
2755:
2752:
2749:
2747:
2744:
2742:
2738:
2735:
2734:
2732:
2730:
2726:
2723:
2721:
2717:
2713:
2708:
2704:
2699:
2695:
2691:
2687:
2680:
2675:
2673:
2668:
2666:
2661:
2660:
2657:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2626:
2624:
2620:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2584:
2581:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2549:
2546:
2543:
2540:
2538:
2534:
2531:
2530:
2528:
2526:
2522:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2488:
2486:
2484:
2480:
2472:
2469:
2467:
2463:
2460:
2458:
2455:
2454:
2453:
2450:
2448:
2445:
2444:
2442:
2440:
2436:
2433:
2430:
2425:
2421:
2417:
2414:
2407:
2402:
2400:
2395:
2393:
2388:
2387:
2384:
2380:
2379:
2377:
2376:public domain
2373:
2360:
2356:
2353:: 1511–1515.
2352:
2348:
2340:
2337:
2332:
2328:
2324:
2320:
2316:
2312:
2308:
2304:
2297:
2290:
2288:
2284:
2279:
2275:
2271:
2267:
2263:
2262:10.1038/70496
2259:
2255:
2251:
2244:
2241:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2206:
2202:
2198:
2194:
2187:
2184:
2179:
2175:
2170:
2165:
2161:
2157:
2153:
2149:
2145:
2138:
2136:
2132:
2127:
2123:
2118:
2113:
2108:
2103:
2099:
2095:
2088:
2086:
2084:
2080:
2075:
2071:
2066:
2061:
2056:
2051:
2047:
2043:
2039:
2032:
2030:
2028:
2024:
2019:
2015:
2011:
2007:
2003:
1999:
1992:
1989:
1984:
1980:
1976:
1972:
1967:
1962:
1958:
1954:
1950:
1943:
1940:
1935:
1931:
1926:
1921:
1916:
1911:
1907:
1903:
1899:
1892:
1889:
1884:
1880:
1875:
1870:
1865:
1860:
1856:
1852:
1848:
1844:
1840:
1833:
1830:
1825:
1821:
1817:
1813:
1806:
1803:
1798:
1794:
1789:
1784:
1780:
1776:
1772:
1765:
1762:
1757:
1753:
1748:
1743:
1738:
1733:
1729:
1725:
1721:
1717:
1713:
1706:
1703:
1698:
1694:
1689:
1684:
1680:
1676:
1672:
1668:
1664:
1657:
1654:
1649:
1645:
1641:
1637:
1632:
1627:
1623:
1619:
1615:
1608:
1606:
1602:
1597:
1593:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1548:
1545:
1541:
1536:
1530:
1526:
1521:
1516:
1511:
1506:
1502:
1498:
1494:
1487:
1485:
1483:
1481:
1479:
1477:
1475:
1473:
1469:
1464:
1458:
1456:
1454:
1450:
1445:
1441:
1436:
1431:
1426:
1421:
1417:
1413:
1409:
1405:
1401:
1394:
1392:
1390:
1388:
1384:
1379:
1375:
1369:
1366:
1361:
1357:
1351:
1348:
1344:
1340:
1335:
1333:
1331:
1327:
1323:
1319:
1314:
1312:
1310:
1306:
1299:
1297:
1295:
1291:
1283:
1281:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1242:glutamic acid
1239:
1235:
1231:
1227:
1212:
1207:
1200:
1195:
1191:
1184:
1179:
1169:
1167:
1163:
1159:
1155:
1151:
1147:
1146:retinochromes
1143:
1139:
1135:
1131:
1127:
1119:
1117:
1114:
1110:
1102:
1100:
1098:
1094:
1090:
1086:
1082:
1079:of the human
1078:
1077:keratinocytes
1074:
1070:
1066:
1062:
1054:
1052:
1050:
1046:
1042:
1037:
1035:
1032:
1028:
1024:
1020:
1012:
1010:
1008:
1004:
1000:
996:
992:
989:
985:
981:
969:
964:
960:
956:
953:
949:
942:
940:
937:
933:
929:
925:
922:
918:
914:
907:
905:
899:
895:
892:
886:
884:
878:
874:
871:
867:
860:
858:
852:
848:
845:
839:
837:
831:
827:
824:
822:RefSeq (mRNA)
820:
813:
812:
807:
803:
800:
794:
793:
788:
784:
781:
779:
775:
768:
767:
762:
758:
755:
749:
748:
743:
739:
736:
734:
730:
723:
722:
717:
713:
710:
704:
703:
698:
694:
691:
689:
685:
682:
679:
677:
674:
670:
667:
663:
659:
652:
648:
643:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
603:
601:
598:
597:
591:
588:
586:
583:
581:
578:
576:
573:
572:
570:
567:
566:
560:
557:
555:
552:
550:
547:
545:
542:
541:
539:
536:
535:
532:
531:Gene ontology
528:
524:
512:
507:
503:
498:
495:
493:
489:
481:
476:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
428:
425:
421:
416:
413:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
366:
363:
359:
354:
351:
350:
347:
345:
341:
339:
338:
334:
333:
330:
328:
324:
320:
316:
312:
304:
299:
295:
291:
286:
276:
272:
265:
258:
252:
245:
237:
233:
229:
224:
220:
215:
211:
203:
198:
194:
190:
185:
175:
171:
164:
157:
151:
144:
140:
134:
130:
126:
121:
117:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
68:
60:
55:
48:
43:
38:
34:
29:
24:
19:
5317:
5284:
5257:Metabotropic
5121:
5006:
4959:
4917:
4883:
4854:
4825:
4727:
4670:
4295:
4144:
4095:Urotensin-II
4035:Somatostatin
3990:Prokineticin
3887:Melanocortin
3590:
3523:Neuropeptide
3462:Oxoglutarate
3304:
3266:Prostacyclin
3235:
3222:
3175:
3063:GHB receptor
2964:
2907:
2505:
2369:
2368:
2350:
2346:
2339:
2309:(1): 31–37.
2306:
2302:
2253:
2249:
2243:
2200:
2196:
2186:
2151:
2147:
2097:
2045:
2042:BMC Genomics
2041:
2001:
1997:
1991:
1956:
1952:
1942:
1905:
1901:
1891:
1846:
1842:
1832:
1815:
1811:
1805:
1778:
1774:
1764:
1719:
1715:
1705:
1673:(3376): 65.
1670:
1666:
1656:
1621:
1618:FEBS Letters
1617:
1561:
1557:
1547:
1503:(15): 2441.
1500:
1496:
1407:
1403:
1377:
1368:
1359:
1350:
1287:
1260:, brown for
1228:above, Each
1223:
1162:paraphyletic
1123:
1106:
1097:pineal gland
1085:cell culture
1058:
1038:
1016:
987:
979:
978:
901:
880:
854:
833:
809:
790:
764:
745:
719:
700:
680:
675:
458:ciliary body
342:
335:
301:129,616,236
288:129,598,057
200:109,849,123
187:109,827,972
62:External IDs
18:
4965:Latrophilin
4100:Vasopressin
4085:Thyrotropin
3662:Angiotensin
3615:Neurotensin
3292:Cannabinoid
3271:Thromboxane
2452:Cone opsins
1258:echinoderms
40:Identifiers
5578:Categories
5555:Smoothened
5548:Smoothened
5471:Smoothened
5130:Calcitonin
4065:Tachykinin
3962:, but not
3956:Nociceptin
3822:Kisspeptin
3740:Endothelin
3703:Bradykinin
3591:Neuromedin
3168:Eicosanoid
2797:Purinergic
2729:Adrenergic
2525:Crystallin
2491:Melanopsin
2100:: evw248.
1345:, May 2017
1324:, May 2017
1300:References
1278:cnidarians
1270:arthropods
1234:amino acid
1166:cnidarians
1150:neuropsins
1142:RGR-opsins
1109:chromosome
1061:microvilli
1027:amino acid
346:(ortholog)
83:HomoloGene
5465:Class F:
5264:pheromone
5260:glutamate
4684:Olfactory
3720:Chemokine
3502:Succinate
3287:Bile acid
3095:Melatonin
3068:Histamine
2908:(all but
2900:Serotonin
2805:Adenosine
2707:Rhodopsin
2639:Recoverin
2483:nonvisual
2447:Rhodopsin
2203:: 11885.
1290:RGR-opsin
1262:nematodes
1250:craniates
1226:phylogeny
1158:Bilateria
1130:craniates
1126:craniates
1120:Phylogeny
1071:from the
1069:vitamin A
1041:amphioxus
1034:rhodopsin
904:NP_033128
883:NP_006574
857:NM_009102
836:NM_006583
666:Orthologs
91:GeneCards
5489:Frizzled
5482:Frizzled
5467:Frizzled
5309:, type 2
5215:Secretin
5155:Glucagon
4860:Cadherin
4818:Adhesion
4805:Secretin
4138:, bitter
3985:Oxytocin
3682:Bombesin
3330:Estrogen
3031:Dopamine
2629:Arrestin
2416:proteins
2359:17167409
2323:17454745
2278:35176366
2270:10581022
2235:26154478
2178:22012981
2126:27797948
2074:12542842
2048:(1): 3.
2018:14985289
1975:27676658
1934:29109151
1883:16589909
1797:13367054
1756:16589696
1648:11669142
1640:12435605
1596:32243853
1529:35954284
1341:–
1320:–
1274:mollusks
1266:annelids
1246:arginine
1132:are the
1089:UV light
980:Peropsin
952:Wikidata
645:Sources:
585:membrane
368:testicle
5278:, sweet
5253:Class C
5185:PACAPR1
4801:Class B
4010:Relaxin
3932:Motilin
3817:Ghrelin
3782:Galanin
3515:Peptide
2703:Class A
2466:OPN1MW2
2226:5155618
2205:Bibcode
2169:3223661
2117:5521729
1983:1373924
1925:5766940
1851:Bibcode
1724:Bibcode
1697:4022911
1675:Bibcode
1587:7252503
1566:Bibcode
1520:9368030
1444:9275222
1412:Bibcode
1343:Ensembl
1322:Ensembl
1224:In the
1138:mammals
1113:introns
1093:chicken
1063:of the
1049:retinal
997:to the
984:protein
778:UniProt
733:Ensembl
672:Species
651:QuickGO
321:pattern
79:1097709
47:Aliases
5469:&
5398:GPRC6A
5135:CALCRL
4999:Orphan
4288:Orphan
4279:type 1
3970:Orexin
3958:&
3937:Opioid
3677:Apelin
2471:OPN1SW
2462:OPN1MW
2457:OPN1LW
2439:visual
2357:
2331:225451
2329:
2321:
2276:
2268:
2233:
2223:
2176:
2166:
2124:
2114:
2072:
2065:149353
2062:
2016:
1981:
1973:
1932:
1922:
1881:
1874:534254
1871:
1795:
1754:
1747:528115
1744:
1695:
1667:Nature
1646:
1638:
1594:
1584:
1527:
1517:
1442:
1432:
1288:Since
1238:lysine
1154:opsins
1144:, the
1073:retina
1031:cattle
1023:lysine
1007:humans
995:opsins
938:search
936:PubMed
811:O35214
792:O14718
688:Entrez
492:BioGPS
462:embryo
450:morula
438:zygote
71:605224
5318:Other
5285:TAS1R
5276:Taste
5174:GLP2R
5169:GLP1R
5122:Other
4987:ELTD1
4960:ADGRL
4918:ADGRG
4884:ADGRE
4855:ADGRC
4826:ADGRB
4807:-like
4689:Opsin
4671:Other
4145:TAS2R
4136:Taste
3964:Sigma
3946:Kappa
3941:Delta
3649:C5a (
3634:Other
3280:Other
3208:FPRL1
3176:CysLT
2994:Other
2945:5-HT2
2915:5-HT1
2910:5-HT3
2709:-like
2622:Other
2583:Gamma
2533:Alpha
2424:Opsin
2327:S2CID
2299:(PDF)
2274:S2CID
1979:S2CID
1693:S2CID
1644:S2CID
1497:Cells
1435:23288
1230:clade
1134:taxon
721:20132
702:10692
681:Mouse
676:Human
647:Amigo
344:Mouse
337:Human
284:Start
219:Mouse
183:Start
116:Human
87:55977
5423:RAIG
5331:GABA
5164:GIPR
4911:CD97
4759:SREB
4560:137B
4535:109B
4530:109A
3960:Zeta
3917:MCHR
3697:NMBR
3692:GRPR
3687:BRS3
3325:EBI2
3191:LTB4
3115:TAAR
2965:5-HT
2548:Beta
2501:OPN5
2496:OPN3
2355:PMID
2319:PMID
2266:PMID
2231:PMID
2174:PMID
2122:PMID
2070:PMID
2014:PMID
1971:PMID
1930:PMID
1879:PMID
1793:PMID
1752:PMID
1636:PMID
1592:PMID
1525:PMID
1440:PMID
1081:skin
1043:, a
1005:and
1003:mice
991:gene
454:lens
327:Bgee
275:Band
236:Chr.
179:4q25
174:Band
133:Chr.
67:OMIM
5417:179
5412:158
5407:156
5403:GPR
5190:GPR
5111:157
5106:155
5101:144
5096:143
5091:133
5086:128
5081:126
5076:125
5071:124
5066:123
5061:116
5056:115
5051:114
5046:113
5041:112
5036:111
5031:110
5007:GPR
4889:EMR
4728:RRH
4723:RGR
4718:1SW
4713:1MW
4708:1LW
4660:183
4655:182
4650:177
4645:176
4640:174
4635:173
4630:171
4625:162
4620:161
4615:160
4610:153
4605:152
4600:151
4595:150
4590:149
4585:148
4580:146
4575:142
4570:141
4565:139
4555:135
4550:132
4545:120
4540:119
4525:103
4520:101
4296:GPR
3832:MAS
3777:FSH
3645:C3a
3531:B/W
3467:PAF
3319:119
3305:GPR
3301:CB2
3296:CB1
3257:),
3234:),
3213:OXE
2830:P2Y
2819:A2B
2814:A2A
2511:RGR
2506:RRH
2413:Eye
2311:doi
2258:doi
2221:PMC
2213:doi
2164:PMC
2156:doi
2152:279
2112:PMC
2102:doi
2060:PMC
2050:doi
2006:doi
1961:doi
1920:PMC
1910:doi
1906:292
1869:PMC
1859:doi
1820:doi
1783:doi
1779:222
1742:PMC
1732:doi
1683:doi
1671:134
1626:doi
1622:531
1582:PMC
1574:doi
1515:PMC
1505:doi
1430:PMC
1420:doi
1039:In
988:RRH
297:End
196:End
99:OMA
95:RRH
75:MGI
54:RRH
31:RRH
5580::
5538:10
5394:))
5262:/
5255::
5159:GR
5026:98
5021:97
5016:64
5011:56
4803::
4515:92
4510:88
4505:87
4500:85
4495:84
4490:83
4485:82
4480:81
4475:78
4470:75
4465:68
4460:65
4455:63
4450:62
4445:61
4440:55
4435:52
4430:50
4425:45
4420:44
4415:42
4410:39
4405:37
4400:35
4395:34
4390:33
4385:32
4380:31
4375:27
4370:26
4365:25
4360:23
4355:22
4350:21
4345:20
4340:19
4335:18
4330:17
4325:15
4320:12
4270:60
4265:50
4260:46
4255:45
4250:43
4245:42
4240:41
4235:40
4230:39
4225:38
4220:31
4215:30
4210:20
4205:19
4200:16
4195:14
4190:13
4185:10
4109:1B
4104:1A
3951:Mu
3881:X4
3876:X3
3871:X2
3866:X1
3841:1L
3712:B2
3707:B1
3658:))
3611:))
3546:FF
3321:))
3314:55
3309:18
3303:,
3259:FP
3236:EP
3223:DP
3109:1C
3104:1B
3099:1A
3088:H4
3083:H3
3078:H2
3073:H1
3056:D5
3051:D4
3046:D3
3041:D2
3036:D1
3025:M5
3020:M4
3015:M3
3010:M2
3005:M1
2974:5A
2889:14
2884:13
2879:12
2874:11
2869:10
2824:A3
2809:A1
2787:β3
2782:β2
2777:β1
2757:α2
2737:α1
2705::
2688::
2577:B3
2572:B2
2567:B1
2562:A4
2557:A2
2552:A1
2351:12
2349:.
2325:.
2317:.
2307:28
2305:.
2301:.
2286:^
2272:.
2264:.
2254:23
2252:.
2229:.
2219:.
2211:.
2199:.
2195:.
2172:.
2162:.
2150:.
2146:.
2134:^
2120:.
2110:.
2096:.
2082:^
2068:.
2058:.
2044:.
2040:.
2026:^
2012:.
2002:45
2000:.
1977:.
1969:.
1957:25
1955:.
1951:.
1928:.
1918:.
1904:.
1900:.
1877:.
1867:.
1857:.
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1845:.
1841:.
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1814:.
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1560:.
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1499:.
1495:.
1471:^
1452:^
1438:.
1428:.
1418:.
1408:94
1406:.
1402:.
1386:^
1376:.
1358:.
1329:^
1308:^
1168:.
1021:a
649:/
303:bp
290:bp
202:bp
189:bp
97:;
93::
89:;
85::
81:;
77::
73:;
69::
5540:)
5533:9
5528:8
5523:7
5518:6
5513:5
5508:4
5503:3
5498:2
5493:1
5491:(
5444:)
5442:4
5437:3
5432:2
5427:1
5425:(
5419:)
5405:(
5392:8
5387:7
5382:6
5377:5
5372:4
5367:3
5362:2
5357:1
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5351:(
5345:)
5343:2
5338:1
5336:(
5333:B
5300:3
5295:2
5290:1
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5229:2
5224:1
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5211:)
5209:2
5204:1
5202:(
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5157:(
5151:)
5149:2
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5142:(
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5009:(
4980:3
4975:2
4970:1
4953:7
4948:6
4943:5
4938:4
4933:3
4928:2
4923:1
4904:3
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4894:1
4875:3
4870:2
4865:1
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4773:3
4768:2
4763:1
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4753:4
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4738:1
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4730:)
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4693:3
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4165:5
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4081:)
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4031:)
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4024:3
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3994:1
3992:(
3981:)
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3939:(
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3856:F
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3806:1
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3745:A
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3734:B
3729:A
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2602:D
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