310:
287:
184:
209:
561:
316:
215:
29:
2944:
2039:
Ceballos E, Muñoz-Alonso MJ, Berwanger B, Acosta JC, Hernández R, Krause M, Hartmann O, Eilers M, León J (June 2005). "Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes".
1418:
Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chrétien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rötig A (June 2007). "Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion".
55:
1639:
Acham-Roschitz B, Plecko B, Lindbichler F, Bittner R, Mache CJ, Sperl W, Mayr JA (November 2009). "A novel mutation of the RRM2B gene in an infant with early fatal encephalomyopathy, central hypomyelination, and tubulopathy".
2203:
Okumura H, Natsugoe S, Yokomakura N, Kita Y, Matsumoto M, Uchikado Y, Setoyama T, Owaki T, Ishigami S, Aikou T (June 2006). "Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma".
1982:
Zhou B, Liu X, Mo X, Xue L, Darwish D, Qiu W, Shih J, Hwu EB, Luh F, Yen Y (October 2003). "The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53".
2173:
Qiu W, Zhou B, Darwish D, Shao J, Yen Y (February 2006). "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits".
1326:
Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y (March 2000). "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage".
1675:
Kropach N, Shkalim-Zemer V, Orenstein N, Scheuerman O, Straussberg R (May 2017). "Novel RRM2B Mutation and Severe
Mitochondrial DNA Depletion: Report of 2 Cases and Review of the Literature".
1878:"Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells"
2270:
Lembo D, Donalisio M, Cornaglia M, Azzimonti B, Demurtas A, Landolfo S (December 2006). "Effect of high-risk human papillomavirus oncoproteins on p53R2 gene expression after DNA damage".
1828:
Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M (September 2011). "Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma".
1961:
Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y (March 2003). "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits".
1911:
Yamaguchi T, Matsuda K, Sagiya Y, Iwadate M, Fujino MA, Nakamura Y, Arakawa H (November 2001). "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint".
1932:
Yanamoto S, Kawasaki G, Yoshitomi I, Mizuno A (February 2003). "Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma".
2128:
2603:
2466:
2608:
323:
222:
1614:
2136:
Ohno K, Tanaka-Azuma Y, Yoneda Y, Yamada T (December 2005). "Genotoxicity test system based on p53R2 gene expression in human cells: examination with 80 chemicals".
2356:
1618:
814:
795:
145:
1718:
Valencia CA, Wang X, Wang J, Peters A, Simmons JR, Moran MC, Mathur A, Husami A, Qian Y, Sheridan R, Bove KE, Witte D, Huang T, Miethke AG (2016).
2471:
1308:
1290:
2299:
Yokomakura N, Natsugoe S, Okumura H, Ikeda R, Uchikado Y, Mataki Y, Takatori H, Matsumoto M, Owaki T, Ishigami S, Aikou T (September 2007).
2964:
2620:
1179:
309:
2349:
1779:"Exome sequencing identifies a novel missense variant in RRM2B associated with autosomal recessive progressive external ophthalmoplegia"
1720:"Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism"
1046:
1053:
286:
2663:
1530:"ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage"
1231:
resistance in human cholangiocarcinoma cells and may be predictive of lack of clinical benefit from gemcitabine for human cancers.
1462:
2630:
2437:
1277:
1256:
2241:
Yen Y, Chu B, Yen C, Shih J, Zhou B (2007). "Enzymatic property analysis of p53R2 subunit of human ribonucleotide reductase".
2342:
2819:
1273:
208:
183:
52:
1167:
2006:"In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase"
1252:
125:
2625:
1159:
322:
221:
2934:
2301:"Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma"
2804:
315:
214:
2920:
2907:
2894:
2881:
2868:
2855:
2842:
2576:
2527:
2504:
2481:
2447:
2419:
2379:
2814:
1876:
Guittet O, Håkansson P, Voevodskaya N, Fridd S, Gräslund A, Arakawa H, Nakamura Y, Thelander L (November 2001).
2768:
2711:
2585:
2517:
2461:
2370:
1132:
859:
133:
2485:
2716:
1123:, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.
840:
2737:
2656:
2122:
2809:
2392:
2145:
1731:
1541:
1335:
1120:
197:
112:
1615:"RRM2B-related mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy"
2773:
2615:
2590:
1214:
1207:
1029:
1025:
996:
992:
966:
962:
937:
933:
2969:
2706:
2595:
2229:
2065:
1853:
1700:
1444:
1359:
1150:
synthesis in non-proliferating cells. The other form of R2 is expressed only in dividing cells.
157:
116:, MTDPS8A, MTDPS8B, P53R2, ribonucleotide reductase regulatory TP53 inducible subunit M2B, RCDFRD
1021:
1000:
958:
929:
560:
2322:
2287:
2258:
2221:
2191:
2161:
2110:
2057:
2027:
1992:
1970:
1949:
1920:
1899:
1845:
1810:
1759:
1692:
1657:
1596:
1569:
1507:
1436:
1400:
1351:
105:
45:
2079:"Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls"
2752:
2747:
2721:
2649:
2456:
2312:
2279:
2250:
2213:
2183:
2153:
2100:
2090:
2049:
2017:
1941:
1889:
1837:
1800:
1790:
1749:
1739:
1684:
1649:
1559:
1549:
1497:
1489:
1428:
1390:
1343:
1206:
have been associated with mutations in this gene. MDDS is fatal, with death occurring from
402:
333:
277:
232:
153:
2799:
2783:
2696:
1221:
1203:
377:
2149:
2077:
Deng ZL, Xie DW, Bostick RM, Miao XJ, Gong YL, Zhang JH, Wargovich MJ (September 2005).
1735:
1545:
1339:
2948:
2837:
2778:
2366:
2334:
2105:
2078:
1805:
1778:
1754:
1719:
1564:
1529:
1502:
1477:
1191:
1136:
28:
1945:
1142:
to deoxyribonucloside diphosphates. The version of R2 encoded by RRM2B is induced by
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
658:
653:
648:
643:
638:
633:
617:
612:
607:
602:
2958:
2742:
2701:
2432:
1777:
Takata A, Kato M, Nakamura M, Yoshikawa T, Kanba S, Sano A, Kato T (September 2011).
589:
2254:
2233:
2069:
1857:
1448:
137:
2691:
2544:
2283:
2157:
1704:
1363:
395:
174:
2217:
2022:
2005:
715:
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
1744:
1493:
1135:, which generates nucleotide precursors required for DNA replication by reducing
161:
2915:
2850:
2686:
2494:
1653:
1588:
1313:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1295:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1228:
1139:
618:
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
2943:
2187:
1534:
Proceedings of the
National Academy of Sciences of the United States of America
478:
2531:
2508:
2383:
1841:
294:
191:
141:
2095:
1795:
2889:
2863:
1554:
1379:"A ribonucleotide reductase gene is a transcriptional target of p53 and p73"
1187:
1183:
759:
538:
416:
361:
348:
260:
247:
149:
2326:
2291:
2262:
2225:
2195:
2165:
2114:
2061:
2053:
2031:
1996:
1974:
1953:
1924:
1903:
1894:
1877:
1849:
1814:
1763:
1696:
1688:
1661:
1600:
1573:
1511:
1440:
1404:
1395:
1378:
1355:
1093:
1088:
1199:
1195:
1077:
904:
885:
2317:
2300:
2535:
871:
826:
1528:
Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, Yen Y (November 2008).
82:
78:
74:
2902:
2672:
1347:
1220:
Mutations in this gene have been shown to cause progressive external
1109:
1061:
781:
2004:
Shao J, Zhou B, Zhu L, Qiu W, Yuan YC, Xi B, Yen Y (January 2004).
1463:"Entrez Gene: RRM2B ribonucleotide reductase M2 B (TP53 inducible)"
1432:
2876:
2564:
2559:
2554:
2423:
1147:
744:
740:
2549:
2407:
2402:
2397:
1163:
1116:
569:
129:
2645:
2338:
1143:
1478:"Defects in mitochondrial DNA replication and human disease"
2641:
1377:
Nakano K, Bálint E, Ashcroft M, Vousden KH (August 2000).
1131:
RRM2B codes for one of two versions of the R2 subunit of
385:
1227:
Increased expression of RRM2B has been correlated with
1482:
Critical
Reviews in Biochemistry and Molecular Biology
2932:
550:
1213:
It has been associated with some cases of pediatric
1178:
Abnormalities in this gene are one of the causes of
1119:. The gene encoding the RRM2B protein is located on
730:
nucleobase-containing small molecule interconversion
2828:
2792:
2761:
2730:
2679:
2575:
2526:
2503:
2480:
2446:
2418:
2378:
2176:
1014:
985:
951:
922:
2467:4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
1269:
1267:
1265:
1248:
1246:
1244:
675:deoxyribonucleoside triphosphate metabolic process
2127:: CS1 maint: DOI inactive as of September 2024 (
1106:Ribonucleotide-diphosphate reductase subunit M2 B
332:
231:
1523:
1521:
16:Protein-coding gene in the species Homo sapiens
1274:GRCm38: Ensembl release 89: ENSMUSG00000022292
2657:
2350:
1830:Journal of Hepato-Biliary-Pancreatic Sciences
8:
1146:, and is required for normal DNA repair and
659:ribonucleoside-diphosphate reductase complex
2579:: Acting on X-H and Y-H to form an X-Y bond
1253:GRCh38: Ensembl release 89: ENSG00000048392
2664:
2650:
2642:
2357:
2343:
2335:
1619:United States National Library of Medicine
755:
585:
455:Skeletal muscle tissue of rectus abdominis
373:
272:
169:
63:
2316:
2104:
2094:
2021:
1893:
1804:
1794:
1753:
1743:
1563:
1553:
1501:
1394:
705:deoxyribonucleotide biosynthetic process
700:cellular response to DNA damage stimulus
2939:
2472:7-Hydroxymethyl chlorophyll a reductase
1587:Gorman GS, Taylor RW (April 17, 2014).
1240:
501:cardiac muscle tissue of left ventricle
2120:
18:
1595:. University of Washington, Seattle.
1589:"RRM2B-Related Mitochondrial Disease"
337:
298:
293:
236:
195:
190:
7:
2621:Tetrahydrocannabinolic acid synthase
1180:mitochondrial DNA depletion syndrome
1882:The Journal of Biological Chemistry
1011:
982:
948:
919:
895:
876:
850:
831:
805:
786:
555:
473:
411:
390:
14:
2083:World Journal of Gastroenterology
1642:Molecular Genetics and Metabolism
1112:that in humans is encoded by the
2942:
2631:Dichlorochromopyrrolate synthase
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
2438:(Methionine synthase) reductase
2255:10.1016/j.advenzreg.2006.01.016
2284:10.1016/j.virusres.2006.06.011
2158:10.1016/j.mrgentox.2005.09.002
570:More reference expression data
539:More reference expression data
1:
2609:(-)-bisdechlorogeodin-forming
2604:(+)-bisdechlorogeodin-forming
2243:Advances in Enzyme Regulation
2218:10.1158/1078-0432.CCR-05-2416
2023:10.1158/0008-5472.CAN-03-3048
1946:10.1016/S0304-3835(02)00588-8
1168:Ataxia telangiectasia mutated
695:mitochondrial DNA replication
306:
205:
2450:: Acting on CH or CH2 groups
1745:10.1371/journal.pone.0156738
1494:10.3109/10409238.2011.632763
690:response to oxidative stress
2965:Genes on human chromosome 8
2626:Cannabidiolic acid synthase
1654:10.1016/j.ymgme.2009.06.012
2986:
2188:10.1016/j.bbrc.2005.12.019
2820:Michaelis–Menten kinetics
1842:10.1007/s00534-011-0376-7
1309:"Mouse PubMed Reference:"
1291:"Human PubMed Reference:"
1092:
1087:
1083:
1076:
1060:
1041:
1018:
989:
978:
955:
926:
915:
902:
898:
883:
879:
870:
857:
853:
838:
834:
825:
812:
808:
793:
789:
780:
765:
758:
754:
738:
588:
584:
567:
558:
549:
536:
485:
476:
439:quadriceps femoris muscle
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
2712:Diffusion-limited enzyme
2586:Isopenicillin N synthase
2518:Nitrogenase (flavodoxin)
2462:Ribonucleotide reductase
2206:Clinical Cancer Research
2096:10.3748/wjg.v11.i33.5169
1796:10.1186/gb-2011-12-9-r92
1158:RRM2B has been shown to
1133:ribonucleotide reductase
1054:Chr 15: 37.92 – 37.96 Mb
1047:Chr 8: 102.2 – 102.24 Mb
505:Rostral migratory stream
451:tibialis anterior muscle
2099:(inactive 2024-09-12).
1555:10.1073/pnas.0803313105
613:oxidoreductase activity
443:vastus lateralis muscle
2054:10.1038/sj.onc.1208652
1895:10.1074/jbc.M106088200
1689:10.1055/s-0037-1601867
1396:10.1038/sj.onc.1203774
2805:Eadie–Hofstee diagram
2738:Allosteric regulation
459:palpebral conjunctiva
300:Chromosome 15 (mouse)
2815:Lineweaver–Burk plot
2507:: Acting on reduced
2486:iron–sulfur proteins
2393:Superoxide dismutase
1476:Copeland WC (2012).
1210:in early childhood.
680:renal system process
198:Chromosome 8 (human)
67:List of PDB id codes
40:Available structures
2616:Aureusidin synthase
2591:Columbamine oxidase
2318:10.3892/or.18.3.561
2150:2005MRGTE.588...47O
1736:2016PLoSO..1156738V
1546:2008PNAS..10518519C
1340:2000Natur.404...42T
1215:acute liver failure
1208:respiratory failure
1188:developmental delay
447:germinal epithelium
435:islet of Langerhans
2774:Enzyme superfamily
2707:Enzyme promiscuity
2600:Sulochrin oxidase
2596:Reticuline oxidase
1184:Neonatal hypotonia
1174:Clinical relevance
860:ENSMUSG00000022292
685:kidney development
668:Biological process
627:Cellular component
596:Molecular function
2930:
2929:
2639:
2638:
2138:Mutation Research
1103:
1102:
1099:
1098:
1072:
1071:
1037:
1036:
1008:
1007:
974:
973:
945:
944:
911:
910:
892:
891:
866:
865:
847:
846:
821:
820:
802:
801:
750:
749:
720:response to amine
603:metal ion binding
580:
579:
576:
575:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
162:RRM2B - orthologs
94:
93:
90:
89:
50:Ortholog search:
2977:
2947:
2946:
2938:
2810:Hanes–Woolf plot
2753:Enzyme activator
2748:Enzyme inhibitor
2722:Enzyme catalysis
2666:
2659:
2652:
2643:
2457:Xanthine oxidase
2359:
2352:
2345:
2336:
2330:
2320:
2305:Oncology Reports
2295:
2266:
2237:
2199:
2169:
2132:
2126:
2118:
2108:
2098:
2073:
2035:
2025:
2000:
1978:
1957:
1928:
1907:
1897:
1888:(44): 40647–51.
1862:
1861:
1825:
1819:
1818:
1808:
1798:
1774:
1768:
1767:
1757:
1747:
1715:
1709:
1708:
1672:
1666:
1665:
1636:
1630:
1629:
1627:
1625:
1611:
1605:
1604:
1584:
1578:
1577:
1567:
1557:
1540:(47): 18519–24.
1525:
1516:
1515:
1505:
1473:
1467:
1466:
1459:
1453:
1452:
1415:
1409:
1408:
1398:
1374:
1368:
1367:
1348:10.1038/35003506
1323:
1317:
1316:
1305:
1299:
1298:
1287:
1281:
1271:
1260:
1250:
1085:
1084:
1056:
1049:
1032:
1012:
1003:
983:
979:RefSeq (protein)
969:
949:
940:
920:
896:
877:
851:
832:
806:
787:
756:
586:
572:
563:
556:
541:
517:substantia nigra
493:secondary oocyte
481:
479:Top expressed in
474:
427:secondary oocyte
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
2985:
2984:
2980:
2979:
2978:
2976:
2975:
2974:
2955:
2954:
2953:
2941:
2933:
2931:
2926:
2838:Oxidoreductases
2824:
2800:Enzyme kinetics
2788:
2784:List of enzymes
2757:
2726:
2697:Catalytic triad
2675:
2670:
2640:
2635:
2571:
2522:
2499:
2476:
2442:
2414:
2374:
2367:oxidoreductases
2363:
2333:
2298:
2278:(1–2): 189–93.
2269:
2240:
2202:
2172:
2135:
2119:
2089:(33): 5169–73.
2076:
2048:(28): 4559–71.
2038:
2010:Cancer Research
2003:
1991:(20): 6583–94.
1985:Cancer Research
1981:
1963:Cancer Research
1960:
1931:
1919:(22): 8256–62.
1913:Cancer Research
1910:
1875:
1871:
1869:Further reading
1866:
1865:
1827:
1826:
1822:
1776:
1775:
1771:
1730:(8): e0156738.
1717:
1716:
1712:
1677:Neuropediatrics
1674:
1673:
1669:
1638:
1637:
1633:
1623:
1621:
1613:
1612:
1608:
1586:
1585:
1581:
1527:
1526:
1519:
1475:
1474:
1470:
1461:
1460:
1456:
1421:Nature Genetics
1417:
1416:
1412:
1376:
1375:
1371:
1325:
1324:
1320:
1307:
1306:
1302:
1289:
1288:
1284:
1272:
1263:
1251:
1242:
1237:
1222:ophthalmoplegia
1204:lactic acidosis
1176:
1156:
1129:
1094:View/Edit Mouse
1089:View/Edit Human
1052:
1045:
1042:Location (UCSC)
1028:
1024:
1020:
999:
995:
991:
965:
961:
957:
936:
932:
928:
841:ENSG00000048392
734:
710:DNA replication
663:
622:
608:protein binding
568:
537:
528:
523:
519:
515:
513:cingulate gyrus
511:
507:
503:
499:
495:
491:
477:
466:
463:pars reticulata
461:
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
339:15|15 B3.1
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
2983:
2981:
2973:
2972:
2967:
2957:
2956:
2952:
2951:
2928:
2927:
2925:
2924:
2911:
2898:
2885:
2872:
2859:
2846:
2832:
2830:
2826:
2825:
2823:
2822:
2817:
2812:
2807:
2802:
2796:
2794:
2790:
2789:
2787:
2786:
2781:
2776:
2771:
2765:
2763:
2762:Classification
2759:
2758:
2756:
2755:
2750:
2745:
2740:
2734:
2732:
2728:
2727:
2725:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2683:
2681:
2677:
2676:
2671:
2669:
2668:
2661:
2654:
2646:
2637:
2636:
2634:
2633:
2628:
2623:
2618:
2613:
2612:
2611:
2606:
2598:
2593:
2588:
2582:
2580:
2573:
2572:
2570:
2569:
2568:
2567:
2562:
2557:
2552:
2541:
2539:
2524:
2523:
2521:
2520:
2514:
2512:
2501:
2500:
2498:
2497:
2491:
2489:
2478:
2477:
2475:
2474:
2469:
2464:
2459:
2453:
2451:
2444:
2443:
2441:
2440:
2435:
2429:
2427:
2416:
2415:
2413:
2412:
2411:
2410:
2405:
2400:
2389:
2387:
2376:
2375:
2364:
2362:
2361:
2354:
2347:
2339:
2332:
2331:
2296:
2272:Virus Research
2267:
2238:
2212:(12): 3740–5.
2200:
2170:
2133:
2074:
2036:
2001:
1979:
1958:
1934:Cancer Letters
1929:
1908:
1872:
1870:
1867:
1864:
1863:
1820:
1783:Genome Biology
1769:
1710:
1683:(6): 456–462.
1667:
1631:
1606:
1579:
1517:
1468:
1454:
1433:10.1038/ng2040
1410:
1389:(37): 4283–9.
1369:
1334:(6773): 42–9.
1318:
1300:
1282:
1261:
1239:
1238:
1236:
1233:
1192:encephalopathy
1175:
1172:
1155:
1152:
1137:ribonucleoside
1128:
1125:
1101:
1100:
1097:
1096:
1091:
1081:
1080:
1074:
1073:
1070:
1069:
1067:
1065:
1058:
1057:
1050:
1043:
1039:
1038:
1035:
1034:
1016:
1015:
1009:
1006:
1005:
987:
986:
980:
976:
975:
972:
971:
953:
952:
946:
943:
942:
924:
923:
917:
913:
912:
909:
908:
900:
899:
893:
890:
889:
881:
880:
874:
868:
867:
864:
863:
855:
854:
848:
845:
844:
836:
835:
829:
823:
822:
819:
818:
810:
809:
803:
800:
799:
791:
790:
784:
778:
777:
772:
767:
763:
762:
752:
751:
748:
747:
736:
735:
733:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
671:
669:
665:
664:
662:
661:
656:
651:
646:
641:
636:
630:
628:
624:
623:
621:
620:
615:
610:
605:
599:
597:
593:
592:
582:
581:
578:
577:
574:
573:
565:
564:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
497:primary oocyte
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
431:deltoid muscle
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2982:
2971:
2968:
2966:
2963:
2962:
2960:
2950:
2945:
2940:
2936:
2922:
2918:
2917:
2912:
2909:
2905:
2904:
2899:
2896:
2892:
2891:
2886:
2883:
2879:
2878:
2873:
2870:
2866:
2865:
2860:
2857:
2853:
2852:
2847:
2844:
2840:
2839:
2834:
2833:
2831:
2827:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2797:
2795:
2791:
2785:
2782:
2780:
2779:Enzyme family
2777:
2775:
2772:
2770:
2767:
2766:
2764:
2760:
2754:
2751:
2749:
2746:
2744:
2743:Cooperativity
2741:
2739:
2736:
2735:
2733:
2729:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2702:Oxyanion hole
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2684:
2682:
2678:
2674:
2667:
2662:
2660:
2655:
2653:
2648:
2647:
2644:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2610:
2607:
2605:
2602:
2601:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2583:
2581:
2578:
2574:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2547:
2546:
2543:
2542:
2540:
2537:
2533:
2529:
2525:
2519:
2516:
2515:
2513:
2510:
2506:
2502:
2496:
2493:
2492:
2490:
2487:
2483:
2479:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2454:
2452:
2449:
2445:
2439:
2436:
2434:
2433:Ceruloplasmin
2431:
2430:
2428:
2425:
2421:
2417:
2409:
2406:
2404:
2401:
2399:
2396:
2395:
2394:
2391:
2390:
2388:
2385:
2381:
2377:
2372:
2368:
2360:
2355:
2353:
2348:
2346:
2341:
2340:
2337:
2328:
2324:
2319:
2314:
2310:
2306:
2302:
2297:
2293:
2289:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2256:
2252:
2248:
2244:
2239:
2235:
2231:
2227:
2223:
2219:
2215:
2211:
2207:
2201:
2197:
2193:
2189:
2185:
2182:(2): 428–34.
2181:
2177:
2171:
2167:
2163:
2159:
2155:
2151:
2147:
2143:
2139:
2134:
2130:
2124:
2116:
2112:
2107:
2102:
2097:
2092:
2088:
2084:
2080:
2075:
2071:
2067:
2063:
2059:
2055:
2051:
2047:
2043:
2037:
2033:
2029:
2024:
2019:
2015:
2011:
2007:
2002:
1998:
1994:
1990:
1986:
1980:
1976:
1972:
1968:
1964:
1959:
1955:
1951:
1947:
1943:
1940:(2): 233–43.
1939:
1935:
1930:
1926:
1922:
1918:
1914:
1909:
1905:
1901:
1896:
1891:
1887:
1883:
1879:
1874:
1873:
1868:
1859:
1855:
1851:
1847:
1843:
1839:
1836:(5): 700–11.
1835:
1831:
1824:
1821:
1816:
1812:
1807:
1802:
1797:
1792:
1788:
1784:
1780:
1773:
1770:
1765:
1761:
1756:
1751:
1746:
1741:
1737:
1733:
1729:
1725:
1721:
1714:
1711:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1671:
1668:
1663:
1659:
1655:
1651:
1647:
1643:
1635:
1632:
1620:
1616:
1610:
1607:
1602:
1598:
1594:
1590:
1583:
1580:
1575:
1571:
1566:
1561:
1556:
1551:
1547:
1543:
1539:
1535:
1531:
1524:
1522:
1518:
1513:
1509:
1504:
1499:
1495:
1491:
1487:
1483:
1479:
1472:
1469:
1464:
1458:
1455:
1450:
1446:
1442:
1438:
1434:
1430:
1427:(6): 776–80.
1426:
1422:
1414:
1411:
1406:
1402:
1397:
1392:
1388:
1384:
1380:
1373:
1370:
1365:
1361:
1357:
1353:
1349:
1345:
1341:
1337:
1333:
1329:
1322:
1319:
1314:
1310:
1304:
1301:
1296:
1292:
1286:
1283:
1279:
1275:
1270:
1268:
1266:
1262:
1258:
1254:
1249:
1247:
1245:
1241:
1234:
1232:
1230:
1225:
1223:
1218:
1216:
1211:
1209:
1205:
1201:
1197:
1193:
1189:
1185:
1181:
1173:
1171:
1169:
1165:
1161:
1153:
1151:
1149:
1145:
1141:
1138:
1134:
1126:
1124:
1122:
1118:
1115:
1111:
1107:
1095:
1090:
1086:
1082:
1079:
1075:
1068:
1066:
1063:
1059:
1055:
1051:
1048:
1044:
1040:
1033:
1031:
1027:
1023:
1017:
1013:
1010:
1004:
1002:
998:
994:
988:
984:
981:
977:
970:
968:
964:
960:
954:
950:
947:
941:
939:
935:
931:
925:
921:
918:
916:RefSeq (mRNA)
914:
907:
906:
901:
897:
894:
888:
887:
882:
878:
875:
873:
869:
862:
861:
856:
852:
849:
843:
842:
837:
833:
830:
828:
824:
817:
816:
811:
807:
804:
798:
797:
792:
788:
785:
783:
779:
776:
773:
771:
768:
764:
761:
757:
753:
746:
742:
737:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
672:
670:
667:
666:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
634:mitochondrion
632:
631:
629:
626:
625:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
591:
590:Gene ontology
587:
583:
571:
566:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
509:sciatic nerve
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2916:Translocases
2913:
2900:
2887:
2874:
2861:
2851:Transferases
2848:
2835:
2692:Binding site
2545:Glutaredoxin
2530:: Acting on
2484:: Acting on
2422:: Oxidizing
2382:: Acting on
2311:(3): 561–7.
2308:
2304:
2275:
2271:
2246:
2242:
2209:
2205:
2179:
2175:
2144:(1): 47–57.
2141:
2137:
2123:cite journal
2086:
2082:
2045:
2041:
2013:
2009:
1988:
1984:
1969:(5): 980–6.
1966:
1962:
1937:
1933:
1916:
1912:
1885:
1881:
1833:
1829:
1823:
1786:
1782:
1772:
1727:
1723:
1713:
1680:
1676:
1670:
1648:(3): 300–4.
1645:
1641:
1634:
1622:. Retrieved
1609:
1592:
1582:
1537:
1533:
1488:(1): 64–74.
1485:
1481:
1471:
1457:
1424:
1420:
1413:
1386:
1382:
1372:
1331:
1327:
1321:
1312:
1303:
1294:
1285:
1226:
1219:
1212:
1177:
1157:
1154:Interactions
1140:diphosphates
1130:
1121:chromosome 8
1113:
1105:
1104:
1030:NP_001343952
1026:NP_001343951
1019:
997:NP_001165949
993:NP_001165948
990:
967:NM_001357023
963:NM_001357022
956:
938:NM_001172478
934:NM_001172477
927:
903:
884:
858:
839:
813:
794:
774:
769:
401:
394:
259:102,238,961
246:102,204,502
121:External IDs
72:
2687:Active site
2495:Nitrogenase
2386:as acceptor
1593:GeneReviews
1229:gemcitabine
644:nucleoplasm
360:37,961,562
347:37,924,196
99:Identifiers
2959:Categories
2890:Isomerases
2864:Hydrolases
2731:Regulation
2532:phosphorus
2509:flavodoxin
2384:superoxide
2373:1.15–1.21)
2249:: 235–47.
2016:(1): 1–6.
1789:(9): R92.
1280:, May 2017
1259:, May 2017
1235:References
725:DNA repair
405:(ortholog)
142:HomoloGene
2970:EC 1.17.4
2769:EC number
2538:in donors
2488:as donors
1022:NP_955770
1001:NP_056528
959:NM_199476
930:NM_015713
760:Orthologs
649:cytoplasm
150:GeneCards
2793:Kinetics
2717:Cofactor
2680:Activity
2511:as donor
2327:17671702
2292:16872707
2263:16846634
2234:15106205
2226:16778101
2196:16376858
2166:16236544
2115:16127747
2070:21190604
2062:15856024
2042:Oncogene
2032:14729598
1997:14583450
1975:12615712
1954:12565178
1925:11719458
1904:11517226
1858:19975519
1850:21451941
1815:21951382
1764:27483465
1724:PLOS ONE
1697:28482374
1662:19616983
1601:24741716
1574:19015526
1512:22176657
1449:22103978
1441:17486094
1405:10980602
1383:Oncogene
1356:10716435
1276:–
1255:–
1200:deafness
1196:seizures
1182:(MDDS).
1160:interact
1127:Function
1078:Wikidata
739:Sources:
521:habenula
2949:Biology
2903:Ligases
2673:Enzymes
2536:arsenic
2146:Bibcode
2106:4320390
1806:3308055
1755:4970743
1732:Bibcode
1705:7809119
1624:13 July
1565:2587585
1542:Bibcode
1503:3244805
1364:4327888
1336:Bibcode
1278:Ensembl
1257:Ensembl
1194:, with
872:UniProt
827:Ensembl
766:Species
745:QuickGO
654:cytosol
639:nucleus
380:pattern
138:2155865
106:Aliases
2935:Portal
2877:Lyases
2365:Other
2325:
2290:
2261:
2232:
2224:
2194:
2164:
2113:
2103:
2068:
2060:
2030:
1995:
1973:
1952:
1923:
1902:
1856:
1848:
1813:
1803:
1762:
1752:
1703:
1695:
1660:
1599:
1572:
1562:
1510:
1500:
1447:
1439:
1403:
1362:
1354:
1328:Nature
1110:enzyme
1108:is an
1064:search
1062:PubMed
905:Q6PEE3
886:Q7LG56
815:382985
782:Entrez
551:BioGPS
489:zygote
238:8q22.3
130:604712
2829:Types
2565:GLRX5
2560:GLRX3
2555:GLRX2
2424:metal
2230:S2CID
2066:S2CID
1854:S2CID
1701:S2CID
1445:S2CID
1360:S2CID
1162:with
1148:mtDNA
1114:RRM2B
796:50484
775:Mouse
770:Human
741:Amigo
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
154:RRM2B
146:56723
113:RRM2B
22:RRM2B
2921:list
2914:EC7
2908:list
2901:EC6
2895:list
2888:EC5
2882:list
2875:EC4
2869:list
2862:EC3
2856:list
2849:EC2
2843:list
2836:EC1
2577:1.21
2550:GLRX
2528:1.20
2505:1.19
2482:1.18
2448:1.17
2426:ions
2420:1.16
2408:SOD3
2403:SOD2
2398:SOD1
2380:1.15
2323:PMID
2288:PMID
2259:PMID
2222:PMID
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