249:
226:
848:, the fetus-maternal interface. Because the placenta is the first organ to form during the development of an embryo, problems in its establishment and biological role lead to complications during gestation. This organ maintains the fetus throughout the pregnancy and is therefore sensitive to disruptions. Studies in mice suggest that disruption of the RTL1 concentration, whether increasing or decreasing the amount of this protein coding gene, can lead to serious errors in the conservation of placental fetal capillaries. RTL1
123:
148:
255:
154:
844:. RTL1 plays an important role in the maintenance of fetal capillaries and is expressed in high quantities during late stage of fetal development. The expression of this gene is important for the development of the
954:
Sekita Y, Wagatsuma H, Nakamura K, Ono R, Kagami M, Wakisaka N, et al. (February 2008). "Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta".
852:
have shown obstruction in fetal development along with late fetal/neonatal death. Studies from sheep homologs suggest that high expression levels of RTL1 can lead to skeletal
262:
161:
574:
555:
84:
1042:"Severe damage to the placental fetal capillary network causes mid- to late fetal lethality and reduction in placental size in Peg11/Rtl1 KO mice"
933:
915:
1138:
248:
774:
781:
225:
902:
881:
147:
122:
898:
877:
64:
261:
160:
254:
153:
619:
72:
840:
derived protein coding gene. It is also known as PEG11 and is a paternally expressed imprinted gene, part of
600:
136:
51:
736:
689:
1022:
979:
853:
841:
96:
757:
710:
1114:
1063:
1014:
971:
44:
1104:
1094:
1053:
1006:
963:
341:
272:
216:
171:
20:
837:
316:
92:
1143:
849:
1109:
1082:
997:
Rossant J, Cross JC (July 2001). "Placental development: lessons from mouse mutants".
1132:
55:, MART1, Mar1, PEG11, retrotransposon-like 1, retrotransposon Gag like 1, SIRH2, HUR1
1081:
Bidwell CA, Kramer LN, Perkins AC, Hadfield TS, Moody DE, Cockett NE (August 2004).
1026:
76:
983:
334:
113:
100:
938:
National Center for
Biotechnology Information, U.S. National Library of Medicine
920:
National Center for
Biotechnology Information, U.S. National Library of Medicine
417:
856:
This is due to over-expression patterns in the paternal allele specific gene.
233:
130:
80:
519:
477:
355:
300:
287:
199:
186:
88:
1118:
1099:
1083:"Expression of PEG11 and PEG11AS transcripts in normal and callipyge sheep"
1067:
1018:
975:
821:
816:
845:
805:
664:
645:
967:
631:
586:
1058:
1041:
1010:
789:
541:
1040:
Kitazawa M, Tamura M, Kaneko-Ishino T, Ishino F (February 2017).
68:
324:
19:
This article is about the gene. For the locomotive, see
489:
750:
729:
703:
682:
894:
892:
890:
873:
871:
869:
271:
170:
16:Protein-coding gene in the species Homo sapiens
899:GRCm38: Ensembl release 89: ENSMUSG00000085925
8:
878:GRCh38: Ensembl release 89: ENSG00000254656
515:
312:
211:
108:
1108:
1098:
1057:
865:
949:
947:
25:
276:
237:
232:
175:
134:
129:
7:
747:
726:
700:
679:
655:
636:
610:
591:
565:
546:
494:
412:
350:
329:
14:
260:
253:
247:
224:
159:
152:
146:
121:
836:(retrotransposon like 1) is a
478:More reference expression data
1:
245:
144:
1139:Genes on human chromosome 14
1160:
782:Chr 12: 109.56 – 109.57 Mb
18:
934:"Mouse PubMed Reference:"
916:"Human PubMed Reference:"
820:
815:
811:
804:
788:
775:Chr 14: 100.88 – 100.9 Mb
769:
754:
733:
722:
707:
686:
675:
662:
658:
643:
639:
630:
617:
613:
598:
594:
585:
572:
568:
553:
549:
540:
525:
518:
514:
502:
497:
488:
475:
424:
415:
362:
353:
323:
315:
311:
294:
281:
244:
223:
214:
210:
193:
180:
143:
120:
111:
107:
62:
59:
49:
42:
37:
33:
28:
999:Nature Reviews. Genetics
464:internal granular layer
1100:10.1186/1741-7007-2-17
460:superior frontal gyrus
239:Chromosome 12 (mouse)
137:Chromosome 14 (human)
440:striatum of neuraxis
398:right adrenal gland
390:left adrenal cortex
968:10.1038/ng.2007.51
854:muscle hypertrophy
842:genomic imprinting
620:ENSMUSG00000085925
448:intercostal muscle
1059:10.1111/gtc.12465
831:
830:
827:
826:
800:
799:
765:
764:
744:
743:
718:
717:
697:
696:
671:
670:
652:
651:
626:
625:
607:
606:
581:
580:
562:
561:
510:
509:
506:
505:
484:
483:
471:
470:
428:crus of diaphragm
409:
408:
307:
306:
206:
205:
1151:
1123:
1122:
1112:
1102:
1078:
1072:
1071:
1061:
1037:
1031:
1030:
1011:10.1038/35080570
994:
988:
987:
951:
942:
941:
930:
924:
923:
912:
906:
896:
885:
875:
813:
812:
784:
777:
760:
748:
739:
727:
723:RefSeq (protein)
713:
701:
692:
680:
656:
637:
611:
592:
566:
547:
516:
495:
480:
420:
418:Top expressed in
413:
386:substantia nigra
358:
356:Top expressed in
351:
330:
313:
303:
290:
279:
264:
257:
251:
240:
228:
212:
202:
189:
178:
163:
156:
150:
139:
125:
109:
103:
101:RTL1 - orthologs
54:
47:
26:
21:V/Line RTL class
1159:
1158:
1154:
1153:
1152:
1150:
1149:
1148:
1129:
1128:
1127:
1126:
1080:
1079:
1075:
1039:
1038:
1034:
996:
995:
991:
956:Nature Genetics
953:
952:
945:
932:
931:
927:
914:
913:
909:
897:
888:
876:
867:
862:
838:retrotransposon
822:View/Edit Mouse
817:View/Edit Human
780:
773:
770:Location (UCSC)
756:
735:
709:
688:
601:ENSG00000254656
476:
467:
462:
458:
454:
450:
446:
442:
438:
434:
430:
416:
405:
400:
396:
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388:
384:
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376:
372:
368:
354:
298:
285:
277:
267:
266:
265:
258:
238:
215:Gene location (
197:
184:
176:
166:
165:
164:
157:
135:
112:Gene location (
63:
50:
43:
24:
17:
12:
11:
5:
1157:
1155:
1147:
1146:
1141:
1131:
1130:
1125:
1124:
1073:
1052:(2): 174–188.
1046:Genes to Cells
1032:
989:
943:
925:
907:
886:
864:
863:
861:
858:
829:
828:
825:
824:
819:
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724:
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634:
628:
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624:
623:
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589:
583:
582:
579:
578:
570:
569:
563:
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532:
527:
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522:
512:
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481:
473:
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433:
429:
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387:
383:
379:
375:
371:
367:
363:
360:
359:
347:
346:
338:
327:
321:
320:
317:RNA expression
309:
308:
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304:
296:
292:
291:
283:
280:
275:
269:
268:
259:
252:
246:
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236:
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229:
221:
220:
208:
207:
204:
203:
195:
191:
190:
182:
179:
177:14q32.2-q32.31
174:
168:
167:
158:
151:
145:
141:
140:
133:
127:
126:
118:
117:
105:
104:
61:
57:
56:
48:
40:
39:
35:
34:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
1156:
1145:
1142:
1140:
1137:
1136:
1134:
1120:
1116:
1111:
1106:
1101:
1096:
1092:
1088:
1084:
1077:
1074:
1069:
1065:
1060:
1055:
1051:
1047:
1043:
1036:
1033:
1028:
1024:
1020:
1016:
1012:
1008:
1005:(7): 538–48.
1004:
1000:
993:
990:
985:
981:
977:
973:
969:
965:
961:
957:
950:
948:
944:
939:
935:
929:
926:
921:
917:
911:
908:
904:
900:
895:
893:
891:
887:
883:
879:
874:
872:
870:
866:
859:
857:
855:
851:
850:knockout mice
847:
843:
839:
835:
823:
818:
814:
810:
807:
803:
796:
794:
791:
787:
783:
779:
776:
772:
768:
761:
759:
753:
749:
746:
740:
738:
732:
728:
725:
721:
714:
712:
706:
702:
699:
693:
691:
685:
681:
678:
676:RefSeq (mRNA)
674:
667:
666:
661:
657:
654:
648:
647:
642:
638:
635:
633:
629:
622:
621:
616:
612:
609:
603:
602:
597:
593:
590:
588:
584:
577:
576:
571:
567:
564:
558:
557:
552:
548:
545:
543:
539:
536:
533:
531:
528:
524:
521:
517:
513:
501:
496:
493:
491:
487:
479:
474:
463:
459:
455:
452:adrenal gland
451:
447:
443:
439:
435:
431:
427:
426:
423:
419:
414:
411:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
364:
361:
357:
352:
349:
348:
345:
343:
339:
337:
336:
332:
331:
328:
326:
322:
318:
314:
310:
302:
297:
293:
289:
284:
278:12|12 F1
274:
270:
263:
256:
250:
243:
235:
231:
227:
222:
218:
213:
209:
201:
196:
192:
188:
183:
173:
169:
162:
155:
149:
142:
138:
132:
128:
124:
119:
115:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
66:
58:
53:
46:
41:
36:
32:
27:
22:
1090:
1086:
1076:
1049:
1045:
1035:
1002:
998:
992:
962:(2): 243–8.
959:
955:
937:
928:
919:
910:
833:
832:
755:
737:NP_001128360
734:
708:
690:NM_001134888
687:
663:
644:
618:
599:
573:
554:
534:
529:
444:hypothalamus
374:hypothalamus
340:
333:
299:109,566,764
286:109,555,627
198:100,903,722
185:100,879,753
60:External IDs
1087:BMC Biology
402:right ovary
378:sural nerve
38:Identifiers
1133:Categories
905:, May 2017
884:, May 2017
860:References
394:left ovary
344:(ortholog)
81:HomoloGene
758:NP_908998
711:NM_184109
520:Orthologs
89:GeneCards
1119:15298706
1068:28111885
1027:28327869
1019:11433360
976:18176565
901:–
880:–
846:placenta
806:Wikidata
436:placenta
432:yolk sac
370:placenta
366:testicle
984:5455176
903:Ensembl
882:Ensembl
632:UniProt
587:Ensembl
526:Species
319:pattern
77:2656842
45:Aliases
1117:
1110:514575
1107:
1093:: 17.
1066:
1025:
1017:
982:
974:
792:search
790:PubMed
665:Q7M732
646:A6NKG5
575:353326
556:388015
542:Entrez
490:BioGPS
456:tongue
85:120261
69:611896
1144:Genes
1023:S2CID
980:S2CID
535:Mouse
530:Human
382:gonad
342:Mouse
335:Human
282:Start
217:Mouse
181:Start
114:Human
1115:PMID
1064:PMID
1015:PMID
972:PMID
834:RTL1
325:Bgee
273:Band
234:Chr.
172:Band
131:Chr.
93:RTL1
65:OMIM
52:RTL1
29:RTL1
1105:PMC
1095:doi
1054:doi
1007:doi
964:doi
498:n/a
295:End
194:End
97:OMA
73:MGI
1135::
1113:.
1103:.
1089:.
1085:.
1062:.
1050:22
1048:.
1044:.
1021:.
1013:.
1001:.
978:.
970:.
960:40
958:.
946:^
936:.
918:.
889:^
868:^
301:bp
288:bp
200:bp
187:bp
95:;
91::
87:;
83::
79:;
75::
71:;
67::
1121:.
1097::
1091:2
1070:.
1056::
1029:.
1009::
1003:2
986:.
966::
940:.
922:.
219:)
116:)
99::
23:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
