37:
264:
and not only prevent exchange (maintaining the small GTPase in an off-state), but also prevent the small GTPase from localizing at the membrane, which is their place of action. This inhibition can be removed by the action of a GDI displacement factor. GDIs also inhibit
325:
association of Rab5 is similar to that mediated by Rab GDP dissociation inhibitor (GDI). REP-1 and Rab GDI also share other functional properties, including the ability to inhibit the release of GDP and to remove Rab proteins from membranes.
516:
Nishimura N, Goji J, Nakamura H, Orita S, Takai Y, Sano K (November 1995). "Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens".
648:
548:
Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE (May 1996). "Structure and mutational analysis of Rab GDP-dissociation inhibitor".
149:
707:
1064:
641:
1085:
634:
903:
97:
270:
859:
742:
288:
657:
466:"Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes"
169:
616:
361:
714:
1090:
665:
392:
380:
620:
157:
153:
557:
110:
388:
346:
284:
581:
384:
303:
17:
573:
525:
495:
443:
414:"Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI"
330:
257:
176:
144:
876:
565:
485:
477:
433:
425:
269:
by binding to its tail and preventing its insertion into membranes; hence it cannot trigger
843:
136:
376:
561:
938:
481:
438:
413:
350:
249:
490:
465:
1079:
892:
702:
354:
102:
65:
585:
261:
132:
464:
Alexandrov K, Horiuchi H, Steele-Mortimer O, Seabra MC, Zerial M (November 1994).
78:
626:
605:
90:
395:
has shown these regions to play a critical role in the binding of Rab proteins.
299:
690:
685:
315:
281:
429:
291:
is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit
373:
311:
296:
577:
529:
499:
447:
106:
36:
881:
680:
601:
342:
322:
318:
85:
950:
365:
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307:
253:
1040:
1015:
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697:
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following the transfer reaction. The mechanism of REP-1-mediated
260:
membrane traffic. GDIs bind to the GDP-bound form of Rho and Rab
1035:
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922:
917:
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748:
724:
719:
597:
369:
126:
72:
60:
630:
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The structural organisation of domain I is closely related to
287:
is crucial for their membrane association and function. This
412:
Dirac-Svejstrup AB, Sumizawa T, Pfeffer SR (February 1997).
383:
II, are clustered on one face of the domain. The two most
368:. Conserved regions common to GDI and the choroideraemia
341:
of Rab GDI has been determined to a resolution of 1.81
596:
This article incorporates text from the public domain
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314:component, and forms a stable complex with the
41:structure of doubly prenylated ypt1:gdi complex
306:(REP)-1. REP-1 presents newly synthesised Rab
642:
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8:
1065:Guanosine nucleotide dissociation inhibitors
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617:Guanine+Nucleotide+Dissociation+Inhibitors
117:
35:
619:at the U.S. National Library of Medicine
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404:
345:. The protein is composed of two main
26:
7:
349:units: a large complex multi-sheet
302:and an accessory component, termed
273:and cannot lead to nucleation of F-
860:Guanine nucleotide exchange factor
482:10.1002/j.1460-2075.1994.tb06860.x
25:
743:Regulator of G protein signalling
242:Guanosine dissociation inhibitors
256:that serve a regulatory role in
372:product, which delivers Rab to
364:-containing monooxygenases and
289:post-translational modification
18:Rab GDP dissociation inhibitors
1086:GTP-binding protein regulators
658:GTP-binding protein regulators
1:
391:at the apex of the molecule;
121:Available protein structures:
1107:
715:Tuberous sclerosis protein
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240:In molecular biology, the
30:GDP dissociation inhibitor
1026:
867:
666:GTPase activating protein
393:site-directed mutagenesis
381:geranylgeranyltransferase
116:
34:
621:Medical Subject Headings
387:regions form a compact
430:10.1093/emboj/16.3.465
562:1996Natur.381...42S
285:geranylgeranylation
304:Rab escort protein
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353:I, and a smaller
331:crystal structure
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170:structure summary
16:(Redirected from
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1091:Protein families
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877:Son of Sevenless
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736:Heterotrimeric
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556:(6577): 42–8.
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355:alpha-helical
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262:small GTPases
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217:E:5-542
215:
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198:A:1-438
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328:
279:
245:
241:
239:
224:A:5-542
211:A:1-431
199:
192:G:1-449
186:G:1-449
357:domain II.
300:heterodimer
205::1-430
47:Identifiers
1080:Categories
518:Cancer Res
399:References
347:structural
316:prenylated
282:C-terminal
280:The GDIs'
133:structures
674:Monomeric
606:IPR018203
389:structure
385:conserved
374:catalytic
312:catalytic
297:catalytic
258:vesicular
252:of small
91:IPR018203
882:Ras-GRF1
681:Chimerin
602:InterPro
377:subunits
366:oxidases
343:Angstrom
323:membrane
319:proteins
308:proteins
150:RCSB PDB
86:InterPro
1002:DOCK-D
982:DOCK-C
967:DOCK-B
947:DOCK-A
586:4249512
578:8609986
558:Bibcode
530:7585614
500:7957092
448:9034329
439:1169650
379:of Rab
339:isoform
333:of the
310:to the
254:GTPases
230:R:5-542
66:PF00996
1041:IQSEC2
1016:Dock11
1011:Dock10
893:RhoGEF
698:RasGAP
623:(MeSH)
584:
576:
550:Nature
528:
498:
491:395482
488:
470:EMBO J
446:
436:
351:domain
337:alpha-
335:bovine
293:enzyme
250:family
165:PDBsum
139:
129:
111:SUPFAM
79:CL0063
52:Symbol
1058:Other
1006:Dock9
996:Dock8
991:Dock7
986:Dock6
976:Dock4
971:Dock3
961:Dock5
956:Dock2
951:DOCK1
872:EIF2B
844:RGS21
839:RGS20
834:RGS19
829:RGS18
824:RGS17
819:RGS16
814:RGS14
809:RGS13
804:RGS12
799:RGS11
794:RGS10
708:IQGAP
582:S2CID
275:actin
271:WASPs
267:cdc42
107:SCOPe
98:SCOP2
1036:SIL1
1031:ALS2
939:DOCK
928:FGD4
923:FGD3
918:FGD2
913:FGD1
789:RGS9
784:RGS8
779:RGS7
774:RGS6
769:RGS5
764:RGS4
759:RGS3
754:RGS2
749:RGS1
725:TSC2
720:TSC1
691:CHN2
686:CHN1
600:and
598:Pfam
574:PMID
526:PMID
496:PMID
444:PMID
370:gene
329:The
227:1ltx
221:1vg0
214:1vg9
208:1d5t
202:1gnd
195:1lv0
189:2bcg
183:1ukv
158:PDBj
154:PDBe
137:ECOD
127:Pfam
103:1gnd
75:clan
73:Pfam
61:Pfam
904:FGD
703:NF1
566:doi
554:381
486:PMC
478:doi
434:PMC
426:doi
362:FAD
246:GDI
177:PDB
145:PDB
55:GDI
1082::
745::
604::
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572:.
564:.
552:.
538:^
522:55
520:.
508:^
494:.
484:.
474:13
472:.
468:.
456:^
442:.
432:.
422:16
420:.
416:.
277:.
156:;
152:;
135:/
109:/
105:/
650:e
643:t
636:v
588:.
568::
560::
532:.
502:.
480::
450:.
428::
244:(
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
