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474:. This structure produced is the earliest intermediate in the radicicol biosynthesis, monocillin II. This intermediate is transformed to radicicol through halogenation and epoxide formation performed by RadH and RadP respectively. These enzymes are coded by the genes Rdc2 and Rdc4 in the pathway, and removing either of these results in a product that has the monocillin II core, but does not have either the epoxide or halogen added.
401:
116:
414:
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444:(Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival,
323:
297:
InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
307:
InChI=1/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
564:
Wang, Shuhao; Xu, Yuquan; Maine, Erin A.; Wijeratne, E.M. Kithsiri; Espinosa-Artiles, Patricia; Gunatilaka, A.A. Leslie; Molnár, István (2008).
566:"Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii"
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Winssinger N, Barluanga S (January 2007). "Chemistry and biology of resorcylic acid lactones".
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512:"Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs"
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470:, in which the majority of the core structure is produced in vivo through iterative type I
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Review of the chemistry and biology of resorcylic acid lactones, including radicicol.
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Except where otherwise noted, data are given for materials in their
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61:)-8-Chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6
257:
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464:Biosynthesis of radicicol has been best studied in
510:Zhou H, Qiao K, Gao Z, Vederas JC, Tang Y (2010).
331:C1C2(O2)/C=C\C=C\C(=O)Cc3c(c(cc(c3Cl)O)O)C(=O)O1
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481:Proposed biosynthetic pathway of Radicicol.
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65:-oxirenobenzoxacyclotetradecine-6,12(7
440:, is a natural product that binds to
300:Key: WYZWZEOGROVVHK-GTMNPGAYSA-N
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658:Halogen-containing natural products
310:Key: WYZWZEOGROVVHK-GTMNPGAYBX
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395:(at 25 °C , 100 kPa).
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37:Preferred IUPAC name
522:(53): 41412–41421.
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450:angiogenesis
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157:ChEMBL453386
137:CHEBI:556075
76:Identifiers
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663:Polyketides
610:Chem Commun
454:oncogenesis
340:Properties
195:100.170.695
653:Macrolides
642:Categories
498:References
378:Molar mass
241:I60EH8GECX
168:ChemSpider
104:3D model (
93:12772-57-5
83:CAS Number
17:Radicicol
446:apoptosis
434:Radicicol
648:Epoxides
630:17279252
592:19101477
548:20961859
486:See also
438:monorden
177:20137057
539:3009867
415:what is
413: (
221:6323491
208:PubChem
69:)-dione
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410:verify
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383:364.78
324:SMILES
148:ChEMBL
31:Names
442:Hsp90
289:InChI
128:ChEBI
106:JSmol
626:PMID
588:PMID
544:PMID
452:and
232:UNII
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368:O
359:H
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256:(
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67:H
63:H
59:R
55:R
51:E
47:E
43:R
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