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Radiobiology

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to monitor the effects of radiation in patients of varying proximities to the blast itself, leading to the establishment of three recorded stages of the syndrome. Within 25–30 days of the explosion, the Red Cross surgeon noticed a sharp drop in white blood cell count and established this drop, along with symptoms of fever, as prognostic standards for Acute Radiation Syndrome. Actress
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High radiation dose gives rise to deterministic effects which reliably occur above a threshold, and their severity increases with dose. Deterministic effects are not necessarily more or less serious than stochastic effects; either can ultimately lead to a temporary nuisance or a fatality. Examples of
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The risk for developing radiation-induced cancer at some point in life is greater when exposing a fetus than an adult, both because the cells are more vulnerable when they are growing, and because there is much longer lifespan after the dose to develop cancer. If there is too much radiation exposure
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resulted in a large number of incidents of radiation poisoning, allowing for greater insight into its symptoms and dangers. Red Cross Hospital surgeon Dr. Terufumi Sasaki led intensive research into the Syndrome in the weeks and months following the Hiroshima bombings. Sasaki and his team were able
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When radioactive compounds enter the human body, the effects are different from those resulting from exposure to an external radiation source. Especially in the case of alpha radiation, which normally does not penetrate the skin, the exposure can be much more damaging after ingestion or inhalation.
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with a latent period of years or decades after exposure. The mechanism by which this occurs is well understood, but quantitative models predicting the level of risk remain controversial. The most widely accepted model posits that the incidence of cancers due to ionizing radiation increases linearly
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have been monitoring the health status of the survivors and their descendants since 1946. They have found that radiation exposure increases cancer risk, but also that the average lifespan of survivors was reduced by only a few months compared to those not exposed to radiation. No health effects of
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is a measure of the stochastic health risk due to an intake of radioactive material into the human body. The ICRP states "For internal exposure, committed effective doses are generally determined from an assessment of the intakes of radionuclides from bioassay measurements or other quantities. The
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are an average of about 20 times more dangerous, and in some experiments up to 1000 times more dangerous than an equivalent activity of beta emitting or gamma emitting radioisotopes. If the radiation type is not known, it can be determined by differential measurements in the presence of electrical
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where a radioisotope is used as a drug (usually a liquid or pill). A review of this topic was published in 1999. Because the radioactive material becomes intimately mixed with the affected object it is often difficult to decontaminate the object or person in a case where internal exposure is
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Quantitative data on the effects of ionizing radiation on human health is relatively limited compared to other medical conditions because of the low number of cases to date, and because of the stochastic nature of some of the effects. Stochastic effects can only be measured through large
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both of these produce closely spaced ionizing radiation. This concept is described as a binary system using two separate components for the therapy of cancer. Each component in itself is relatively harmless to the cells, but when combined for treatment they produce a highly cytocidal
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The human body cannot sense ionizing radiation except in very high doses, but the effects of ionization can be used to characterize the radiation. Parameters of interest include disintegration rate, particle flux, particle type, beam energy, kerma, dose rate, and radiation dose.
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Internal exposure occurs when the radioactive material enters the organism, and the radioactive atoms become incorporated into the organism. This can occur through inhalation, ingestion, or injection. Below are a series of examples of internal exposure.
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summarises the recommendations of the ICRU and ICRP on the use of dose quantities and includes a guide to the effects of ionizing radiation as measured in sieverts, and gives examples of approximate figures of dose uptake in certain situations.
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over several years; his death drew public attention to dangers of radiation. By the 1930s, after a number of cases of bone necrosis and death in enthusiasts, radium-containing medical products had nearly vanished from the market.
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stochastic effects, i.e., cancer and heritable effects involving either cancer development in exposed individuals owing to mutation of somatic cells or heritable disease in their offspring owing to mutation of reproductive (germ)
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A schematic diagram showing a rectangle being irradiated by radioactive contamination (shown in red) which is present on an external surface such as the skin; this emits radiation (shown in yellow), which can enter the animal's
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A nuclear worker whose hands have been dirtied with radioactive dust. Assuming that his hands are cleaned before any radioactive material can be absorbed, inhaled or ingested, skin contamination is considered to be external
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The US National Academy of Sciences Biological Effects of Ionizing Radiation Committee "has concluded that there is no compelling evidence to indicate a dose threshold below which the risk of tumor induction is zero".
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epidemiological studies where enough data has been collected to remove confounding factors such as smoking habits and other lifestyle factors. The richest source of high-quality data comes from the study of Japanese
1988:- a powerful electric current produces a transient, spatially focussed magnetic field that can penetrate the scalp and skull of a subject and induce electrical activity in the neurons on the surface of the brain. 1639:
matrix might never be able to truly become part of an organism, it is normal to consider such particles in the lungs and digestive tract as a form of internal contamination which results in internal exposure.
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External exposure is exposure which occurs when the radioactive source (or other radiation source) is outside (and remains outside) the organism which is exposed. Examples of external exposure include:
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Although radiation was discovered in late 19th century, the dangers of radioactivity and of radiation were not immediately recognized. Acute effects of radiation were first observed in the use of
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to the neutron energy spectrum suitable for BNCT treatment. The tumor is selectively bombarded with these neutrons. The neutrons quickly slow down in the body to become low energy
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are used, and appropriate dose factors and coefficients are used to calculate these from the absorbed dose. Equivalent and effective dose quantities are expressed in units of the
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intentionally subjected his fingers to X-rays in 1895. He published his observations concerning the burns that developed, though he misattributed them to ozone, a
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there could be harmful effects on the unborn child or reproductive organs. Research shows that scanning more than once in nine months can harm the unborn child.
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When alpha particle emitting isotopes are ingested, they are far more dangerous than their half-life or decay rate would suggest. This is due to the high
2658:"Image Quality and Radiation Dose of Lower Extremity CT Angiography Using 70 kVp, High Pitch Acquisition and Sinogram-Affirmed Iterative Reconstruction" 1822: 819: 2943: 769:
of alpha radiation to cause biological damage after alpha-emitting radioisotopes enter living cells. Ingested alpha emitter radioisotopes such as
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spoke out against this sort of treatment, warning that the effects of radiation on the human body were not well understood. Curie later died of
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produced in air by X-rays. Other free radicals produced within the body are now understood to be more important. His injuries healed later.
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Zhang, Zhuoli; Qi, Li; Meinel, Felix G.; Zhou, Chang Sheng; Zhao, Yan E.; Schoepf, U. Joseph; Zhang, Long Jiang; Lu, Guang Ming (2014).
123: 1782:, a famous American socialite, died of multiple cancers (but not acute radiation syndrome) in 1932 after consuming large quantities of 3918: 3643: 3486: 1758:
Before the biological effects of radiation were known, many physicians and corporations had begun marketing radioactive substances as
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concluded that these newly discovered rays not only photograph, but also "affect the living function". At the same time, Pierre and
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which implies that biological effects have been taken into account. These are usually in accordance with the recommendations of the
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deterministic effects (harmful tissue reactions) due in large part to the killing or malfunction of cells following high doses; and
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The interactions between organisms and electromagnetic fields (EMF) and ionizing radiation can be studied in a number of ways:
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to estimate, and the irradiated organism does not become radioactive, except for a case where the radiation is an intense
1076:(ICRU). The coherent system of radiological protection quantities developed by them is shown in the accompanying diagram. 229: 214: 1998:, reveals the pattern of blood flow in the brain and can show which parts of the brain are involved in a particular task. 1121: 942: 832: 3374: 1795: 1155:
A schematic diagram showing a rectangle being irradiated by an external source (in red) of radiation (shown in yellow)
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is the most hazardous source of radiation to general public health, followed by medical imaging as a close second.
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In general, ionizing radiation is harmful and potentially lethal to living beings but can have health benefits in
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The genetic effects of radiation, including the effects on cancer risk, were recognized much later. In 1927
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in the 1940s, heightened scientific attention was given to the study of all manner of radiation effects.
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or charged ions. Biological samples can be irradiated using either a broad, uniform beam, or using a
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More generally, the 1930s saw attempts to develop a general model for radiobiology. Notable here was
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Most adverse health effects of radiation exposure may be grouped in two general categories:
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are captured by the injected boron-10, forming excited (boron-11) which breaks down into
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The Institute for Radiation Biology at the Helmholtz-Center for Environmental Health
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The 2007 Recommendations of the International Commission on Radiological Protection
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radiation dose is determined from the intake using recommended dose coefficients".
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Radiobiology experiments typically make use of a radiation source which could be:
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Possible deterministic effects include of radiation exposure in pregnancy include
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Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2
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The added lifetime risk of developing cancer by a single abdominal CT of 8 
1942:- the magnetic properties of living systems (see, for example, the research of 3776: 3286: 3233: 3062:"Experimental Simulation of A-bomb Gamma-ray Spectra for Radiobiology Studies" 2467:
Ronckers, Cécile M; Erdmann, Christine A; Land, Charles E (23 November 2004).
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called X-rays. After irradiating frogs and insects with X-rays in early 1896,
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The monitoring and calculation of doses to safeguard human health is called
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of years or decades after exposure. High doses can cause visually dramatic
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tagged chemical that preferentially binds to tumor cells. Neutrons from a
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The exposure to the ingestion of a soluble radioactive substance, such as
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Ratnapalan, Savithiri; Bentur, Yedidia; Koren, Gideon (2 December 2008).
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Ratnapalan, Savithiri; Bentur, Yedidia; Koren, Gideon (2 December 2008).
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published research showing genetic effects, and in 1946 was awarded the
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United Nations Scientific Committee on the Effects of Atomic Radiation
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uptake and the use of bio-assay for ingested dose. The article on the
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External dose quantities used in radiation protection. See article on
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seems to be particularly high for radiation doses during pregnancy.
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G.Gordon Steel, "Basic Clinical Radiobiology". 2002. Hodder Arnold.
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any sort have thus far been detected in children of the survivors.
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discovered the radioactive polonium and radium later used to treat
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Brisbane, Wayne; Bailey, Michael R.; Sorensen, Mathew D. (2016).
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treatments, and radium-containing waters to be drunk as tonics.
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fields, magnetic fields, or with varying amounts of shielding.
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As a field of medical sciences, radiobiology originated from
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International Commission on Radiation Units and Measurements
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International Commission on Radiation Units and Measurements
2469:"Radiation and breast cancer: a review of current evidence" 934:
The intellectual deficit has been estimated to be about 25
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Pattison JE, Hugtenburg RP, Beddoe AH, Charles MW (2001).
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are all stochastic effects induced by ionizing radiation.
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National Council on Radiation Protection and Measurements
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Other important organizations studying the topic include
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These effects are sometimes relevant when deciding about
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per 1,000 mGy at 10 to 17 weeks of gestational age.
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Christensen DM, Iddins CJ, Sugarman SL (February 2014).
2871:(2nd ed.). Cambridge: Cambridge University Press. 1963:- the electromagnetic properties of living systems and 1631:
occurring. While some very insoluble materials such as
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A person who is being treated for cancer by means of a
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Some effects of ionizing radiation on human health are
2944:"A Glow in the Dark, and a Lesson in Scientific Peril" 1790:
In the United States, the experience of the so-called
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American Congress of Obstetricians and Gynecologists
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International Commission on Radiological Protection
2942: 2786: 2724: 2564:Unless otherwise specified in boxes, reference is: 2247: 2217: 2164: 1686:The radiation exposure is normally expressed as a 1129:Institut de radioprotection et de sûreté nucléaire 1040:is sometimes also used, predominantly in the USA. 2376:""Doctor, will that x-ray harm my unborn child?"" 2317:""Doctor, will that x-ray harm my unborn child?"" 2158: 2156: 2154: 956:Also, the risk for the mother of later acquiring 2601:"An overview of kidney stone imaging techniques" 2093:Biological effects of radiation on the epigenome 2075:, focused down to cellular or subcellular sizes. 2036:Radiation sources for experimental radiobiology 1328:CT of the chest, lung cancer screening protocol 1070:International Committee on Radiation Protection 190:effects are those that reliably occur above a 16:Study of effects of radiation on living things 3644: 3164: 1810:as a field of study. With the development of 1246: 211:, from radiation to a particular body surface 8: 3810:Airborne radioactive particulate monitoring 3123:. ICRP Publication 103. Ann. ICRP 37 (2-4). 2254:. National Academy of Science. p. 10. 2166:"Ionizing radiation injuries and illnesses" 1397:CT of abdomen and pelvis, low dose protocol 3651: 3637: 3629: 3191: 3171: 3157: 3149: 3011:Medicine: A Treasury of Art and Literature 2972:Radium in Humans: A Review of U.S. Studies 1253: 1239: 194:, and their severity increases with dose. 34:that involves the study of the effects of 2925: 2699: 2681: 2632: 2552:, pp. 61–62, paragraphs 104 and 105. 2502: 2484: 2409: 2391: 2350: 2332: 1823:atomic bombings of Hiroshima and Nagasaki 1408:CT of abdomen and pelvis, with + without 1020:representing the mean energy imparted to 820:atomic bombings of Hiroshima and Nagasaki 173:is estimated to be 0.05%, or 1 in 2,000. 133:Its most common impact is the stochastic 2723:Wynn, Volkert; Hoffman, Timothy (1999). 1229: 979:and is undertaken within the science of 828: 780: 751: 249: 2894:"Actions of Radiations on Living Cells" 2560: 2558: 2195:Note: first page available free at URL. 2138: 1180:A space traveller who is irradiated by 1008:Absorbed, equivalent and effective dose 983:. Key measurement tools are the use of 3512:Wireless electronic devices and health 2569:"Radiation Dose in X-Ray and CT Exams" 2441: 2439: 2437: 2435: 2433: 2431: 2429: 1234:Effective dose by medical imaging type 3975:Radiation Protection Convention, 1960 2868:Actions of Radiations on Living Cells 2578:Radiological Society of North America 1996:functional magnetic resonance imaging 1839:Radiation Effects Research Foundation 1806:, a key step in the establishment of 826:has been necessary during pregnancy: 789:on how these are calculated and used. 7: 3538:List of civilian radiation accidents 3507:Wireless device radiation and health 3502:Biological dose units and quantities 3452:Electromagnetic radiation and health 2549: 2537: 2525: 2236:Note: First paragraph provided free. 2204: 2145: 1956:Electromagnetic radiation and health 1889:electromagnetic radiation and health 1135:European Committee on Radiation Risk 523:Cognitive impairment > 24 h 2892:Mitchell, J. S. (2 November 1946). 2479:(1). BMC (Springer Nature): 21–32. 1721:using the newly discovered form of 374:— (patients die in < 48 h) 30:) is a field of clinical and basic 3487:Radioactivity in the life sciences 3081:10.1093/oxfordjournals.rpd.a006532 2726:"Therapeutic Radiopharmaceuticals" 2295:Merck Manuals Professional Edition 2246:National Research Council (2006). 14: 1986:Transcranial magnetic stimulation 1043:To represent stochastic risk the 767:relative biological effectiveness 520:Cognitive impairment 6–20 h 3135:Radiobiology for the Radiologist 2941:Grady, Denise (6 October 1998). 2737:(9). ACS Publications: 2269–92. 2611:(11). Springer Nature: 654–662. 2226:. Harvard University. March 2013 1210:External exposure is relatively 953:exposes the fetus to radiation. 86:for the treatment of cancer and 66:. Controlled doses are used for 62:, and/or rapid fatality through 50:. Its most common impact is the 46:for the treatment of cancer and 38:on living things, in particular 3075:(2). Oxford Academic: 125–136. 2975:. Argonne National Laboratory. 2793:Physics in Medicine and Biology 2108:NASA Space Radiation Laboratory 1835:Atomic Bomb Casualty Commission 1778:caused by radiation poisoning. 205:, by acute whole-body radiation 166:varies greatly across species. 3742:Computed tomography dose index 3069:Radiation Protection Dosimetry 2842:British Institute of Radiology 2103:Health threat from cosmic rays 1124:(NAS through the BEIR studies) 1: 1643:Boron neutron capture therapy 1462:Lower gastrointestinal series 1449:Upper gastrointestinal series 1173:A person who places a sealed 682:— (patients die in < 48h) 230:Radiation-induced lung injury 215:Radiation-induced thyroiditis 2683:10.1371/journal.pone.0099112 2528:, p. 73, paragraph 144. 1645:(BNCT) involves injecting a 1186:A person who is treated for 1122:National Academy of Sciences 1016:is a physical dose quantity 943:medical imaging in pregnancy 387:None to mild (< 10%) 3375:Cosmic background radiation 3009:Carmichael, Ann G. (1991). 2838:"Radiobiology in the 1940s" 2219:"Do CT scans cause cancer?" 2207:, p. 55, Paragraph 83. 2148:, p. 49, paragraph 55. 475:Moderate increase (10–100%) 226:, from long-term radiation. 198:deterministic effects are: 40:health effects of radiation 4071: 4006: 3604: 3462:Lasers and aviation safety 2805:10.1088/0031-9155/21/3/001 1992:Magnetic resonance imaging 1226:By type of medical imaging 845:Estimated threshold dose ( 744:2 days – 2 weeks 303: 224:Chronic radiation syndrome 180: 4004: 3699:Radioactive contamination 3602: 3492:Radioactive contamination 3345:Electromagnetic radiation 3335: 2224:Harvard Health Publishing 2183:10.1016/j.emc.2013.10.002 1894:Specific absorption rates 1727:Ivan Romanovich Tarkhanov 1723:electromagnetic radiation 1575: 1561: 1547: 1534: 1502: 1473: 1380: 1351: 1311: 1281: 1232: 1116:UK Health Security Agency 873: 870: 686: 478:Moderate to severe (100%) 258: 255: 252: 150:is correct, then natural 4050:Radiation health effects 4007:See also the categories 3996:Radiation-induced cancer 3991:Acute radiation syndrome 3605:See also the categories 3543:1996 Costa Rica accident 3204:Acoustic radiation force 2785:Hall, E J (1 May 1976). 2113:Radioactivity in biology 1385:CT of abdomen and pelvis 1369:Coronary CT calcium scan 1271:Effective dose in adults 947:projectional radiography 863:or none (all or nothing) 203:Acute radiation syndrome 183:Acute radiation syndrome 140:effective radiation dose 116:Radiation-induced cancer 64:acute radiation syndrome 3517:Radiation heat-transfer 3370:Gravitational radiation 2617:10.1038/nrurol.2016.154 2540:, p. 24, glossary. 2177:(1). Elsevier: 245–65. 2171:Emerg Med Clin North Am 2063:generating high energy 1930:- their general nature. 1766:. Examples were radium 1600:The exposure caused by 1356:Coronary CT angiography 923:intellectual disability 906:intellectual disability 816:intellectual disability 674:Electrolyte disturbance 653:Electrolyte disturbance 3847:Semiconductor detector 3803:measurement techniques 3558:1990 Zaragoza accident 3553:1984 Moroccan accident 3522:Linear energy transfer 3196:Non-ionizing radiation 2969:Rowland, R.E. (1994). 2605:Nature Reviews Urology 2473:Breast Cancer Research 1702:when German physicist 1165: 1156: 790: 431:Mild to moderate (50%) 142:at a rate of 5.5% per 3866:Protection techniques 3830:Scintillation counter 3548:1987 Goiânia accident 3350:Synchrotron radiation 3340:Earth's energy budget 3322:Radioactive materials 3317:Particle accelerators 2030:Psychoneuroimmunology 2022:Biological psychiatry 2010:Developmental biology 1742:Hermann Joseph Muller 1436:Intravenous pyelogram 1162: 1154: 987:to give the external 784: 526:Rapid incapacitation 393:Heavy (> 95%) 390:Heavy (> 10%) 181:Further information: 160:atomic bomb survivors 4025:Radiation protection 3842:Radiation monitoring 3835:Proportional counter 3720:quantities and units 3674:Background radiation 3660:Radiation protection 3619:Radiation protection 3472:Radiation protection 3360:Black-body radiation 3267:Background radiation 3182:(physics and health) 2765:Radiation Biophysics 2061:particle accelerator 1764:radioactive quackery 1276:background radiation 761:By type of radiation 152:background radiation 26:, and uncommonly as 3857:Whole-body counting 3767:Mean glandular dose 3704:Radioactive sources 3589:Radiation hardening 3531:Radiation incidents 3467:Medical radiography 3426:Radiation syndrome 3380:Cherenkov radiation 2910:1946Natur.158..601M 2799:(3). IOP: 347–359. 2674:2014PLoSO...999112Q 2475:(Review article.). 2393:10.1503/cmaj.080247 2334:10.1503/cmaj.080247 2098:Cell survival curve 1965:Bioelectromagnetics 1961:Bioelectromagnetism 1919:Bioelectromagnetics 1900:Radiation poisoning 1887:High and low-level 1860:Radiation chemistry 1628:radiopharmaceutical 1530:5 weeks - 6 months 1274:Equivalent time of 597:Moderate to severe 232:, from for example 135:induction of cancer 52:induction of cancer 3694:Internal dosimetry 3689:Ionizing radiation 3584:Radioactive source 3405:Radiation exposure 3385:Askaryan radiation 3365:Particle radiation 3249:Ionizing radiation 3137:. 2006. Lippincott 2949:The New York Times 2763:Y. B. Kudriashov. 2733:(Review article). 2607:(Review article). 1905:Radiation oncology 1874:Molecular genetics 1748:for his findings. 1509:X-ray of extremity 1218:beam which causes 1175:radioactive source 1166: 1157: 1026:ionizing radiation 889:Growth restriction 812:growth restriction 791: 36:ionizing radiation 4032: 4031: 4013:Radiation effects 3984:Radiation effects 3747:Counts per minute 3626: 3625: 3607:Radiation effects 3477:Radiation therapy 3413: 3412: 3355:Thermal radiation 3292:Neutron radiation 3257:Radioactive decay 3020:978-0-88363-991-7 2904:(4018): 601–602. 2743:10.1021/cr9804386 2574:RadiologyInfo.org 2386:(12): 1293–1296. 2327:(12): 1293–1296. 2269:978-0-309-09156-5 1976:Radiation therapy 1934:Electrophysiology 1909:radiation therapy 1855:Radiation physics 1846:Areas of interest 1655:neutron moderator 1604:present within a 1588: 1587: 1142:Exposure pathways 1032:(Gy). The non-SI 1024:per unit mass by 958:radiation-induced 932: 931: 824:radiation therapy 758: 757: 583:Mild to moderate 234:radiation therapy 124:cognitive decline 84:radiation therapy 44:radiation therapy 24:radiation biology 4062: 3888:Radon mitigation 3883:Potassium iodide 3801:Instruments and 3653: 3646: 3639: 3630: 3567:Related articles 3482:Radiation damage 3307:Nuclear reactors 3192: 3173: 3166: 3159: 3150: 3108: 3107: 3105: 3099:. Archived from 3066: 3057: 3051: 3050: 3048: 3046: 3041:. 11 August 2016 3031: 3025: 3024: 3006: 3000: 2999: 2997: 2995: 2966: 2960: 2959: 2957: 2955: 2946: 2938: 2932: 2931: 2929: 2918:10.1038/158601a0 2889: 2883: 2882: 2859: 2853: 2852: 2850: 2848: 2831: 2825: 2824: 2790: 2782: 2776: 2761: 2755: 2754: 2731:Chemical Reviews 2728: 2720: 2714: 2713: 2703: 2685: 2653: 2647: 2646: 2636: 2596: 2590: 2589: 2587: 2585: 2562: 2553: 2547: 2541: 2535: 2529: 2523: 2517: 2516: 2506: 2488: 2464: 2458: 2456: 2443: 2424: 2423: 2413: 2395: 2371: 2365: 2364: 2354: 2336: 2312: 2306: 2305: 2303: 2301: 2287: 2281: 2280: 2278: 2276: 2253: 2243: 2237: 2235: 2233: 2231: 2221: 2214: 2208: 2202: 2196: 2194: 2168: 2160: 2149: 2143: 2128:Radiosensitivity 1812:nuclear reactors 1808:nuclear medicine 1663:thermal neutrons 1659:thermal neutrons 1653:are shaped by a 1633:fission products 1521:Lower extremity 1255: 1248: 1241: 1230: 829: 822:and cases where 563:< 7 days 349:< 10 min 250: 242:and infertility. 32:medical sciences 4070: 4069: 4065: 4064: 4063: 4061: 4060: 4059: 4055:Medical physics 4035: 4034: 4033: 4028: 4027: 4009:Medical physics 4000: 3979: 3948: 3897: 3861: 3802: 3796: 3757:Equivalent dose 3719: 3713: 3662: 3657: 3627: 3622: 3621: 3598: 3594:Havana syndrome 3579:Nuclear physics 3562: 3526: 3419: 3409: 3395:Unruh radiation 3331: 3312:Nuclear weapons 3297:Nuclear fission 3243: 3183: 3177: 3130: 3128:Further reading 3116: 3111: 3106:on 16 Jul 2020. 3103: 3064: 3059: 3058: 3054: 3044: 3042: 3033: 3032: 3028: 3021: 3008: 3007: 3003: 2993: 2991: 2968: 2967: 2963: 2953: 2951: 2940: 2939: 2935: 2900:(Book review). 2891: 2890: 2886: 2879: 2861: 2860: 2856: 2846: 2844: 2835:Lea, Douglas E. 2833: 2832: 2828: 2784: 2783: 2779: 2762: 2758: 2722: 2721: 2717: 2655: 2654: 2650: 2598: 2597: 2593: 2583: 2581: 2567: 2565: 2563: 2556: 2548: 2544: 2536: 2532: 2524: 2520: 2466: 2465: 2461: 2445: 2444: 2427: 2373: 2372: 2368: 2314: 2313: 2309: 2299: 2297: 2289: 2288: 2284: 2274: 2272: 2270: 2245: 2244: 2240: 2229: 2227: 2216: 2215: 2211: 2203: 2199: 2162: 2161: 2152: 2144: 2140: 2136: 2089: 2046:isotopic source 2038: 1848: 1816:nuclear weapons 1796:Robley D. Evans 1776:aplastic anemia 1760:patent medicine 1704:Wilhelm Röntgen 1696: 1651:nuclear reactor 1637:uranium dioxide 1593: 1492:CT of the spine 1423:CT Colonography 1316:CT of the chest 1298:With + without 1260: 1259: 1228: 1149: 1144: 1082: 1052: 1045:equivalent dose 1010: 969: 833:Gestational age 796: 763: 676: 672: 668: 666:Severe diarrhea 664: 660: 651: 647: 639: 635: 631: 627: 613: 609: 605: 601: 591: 587: 557:28–31 days 437:Severe (80–90%) 219:hyperthyroidism 209:Radiation burns 185: 179: 164:radioresistance 108: 80: 68:medical imaging 60:radiation burns 22:(also known as 17: 12: 11: 5: 4068: 4066: 4058: 4057: 4052: 4047: 4037: 4036: 4030: 4029: 4005: 4002: 4001: 3999: 3998: 3993: 3987: 3985: 3981: 3980: 3978: 3977: 3972: 3967: 3962: 3956: 3954: 3950: 3949: 3947: 3946: 3941: 3936: 3931: 3926: 3921: 3916: 3911: 3905: 3903: 3899: 3898: 3896: 3895: 3890: 3885: 3880: 3875: 3873:Lead shielding 3869: 3867: 3863: 3862: 3860: 3859: 3854: 3849: 3844: 3838: 3837: 3832: 3827: 3822: 3820:Geiger counter 3817: 3812: 3806: 3804: 3798: 3797: 3795: 3794: 3789: 3784: 3779: 3774: 3769: 3764: 3759: 3754: 3752:Effective dose 3749: 3744: 3739: 3737:Committed dose 3734: 3729: 3723: 3721: 3715: 3714: 3712: 3711: 3706: 3701: 3696: 3691: 3686: 3684:Health physics 3681: 3676: 3670: 3668: 3664: 3663: 3658: 3656: 3655: 3648: 3641: 3633: 3624: 3623: 3603: 3600: 3599: 3597: 3596: 3591: 3586: 3581: 3576: 3570: 3568: 3564: 3563: 3561: 3560: 3555: 3550: 3545: 3540: 3534: 3532: 3528: 3527: 3525: 3524: 3519: 3514: 3509: 3504: 3499: 3494: 3489: 3484: 3479: 3474: 3469: 3464: 3459: 3454: 3449: 3444: 3442:Health physics 3439: 3438: 3437: 3432: 3423: 3421: 3415: 3414: 3411: 3410: 3408: 3407: 3402: 3400:Dark radiation 3397: 3392: 3390:Bremsstrahlung 3387: 3382: 3377: 3372: 3367: 3362: 3357: 3352: 3347: 3342: 3336: 3333: 3332: 3330: 3329: 3324: 3319: 3314: 3309: 3304: 3302:Nuclear fusion 3299: 3294: 3289: 3284: 3279: 3274: 3272:Alpha particle 3269: 3264: 3259: 3253: 3251: 3245: 3244: 3242: 3241: 3236: 3231: 3226: 3221: 3216: 3211: 3206: 3200: 3198: 3189: 3185: 3184: 3178: 3176: 3175: 3168: 3161: 3153: 3147: 3146: 3141: 3138: 3129: 3126: 3125: 3124: 3115: 3112: 3110: 3109: 3052: 3026: 3019: 3001: 2981:10.2172/751062 2961: 2933: 2884: 2877: 2854: 2826: 2777: 2756: 2715: 2648: 2591: 2554: 2542: 2530: 2518: 2486:10.1186/bcr970 2459: 2457:February 2016 2425: 2366: 2307: 2282: 2268: 2260:10.17226/11340 2238: 2209: 2197: 2150: 2137: 2135: 2132: 2131: 2130: 2125: 2120: 2115: 2110: 2105: 2100: 2095: 2088: 2085: 2084: 2083: 2076: 2057: 2037: 2034: 2033: 2032: 2019: 2013: 1999: 1989: 1983: 1978: 1973: 1971:Electrotherapy 1968: 1958: 1952:Magnetobiology 1937: 1931: 1928:Magnetic field 1924:Electric field 1921: 1916: 1902: 1897: 1891: 1885: 1876: 1871: 1862: 1857: 1847: 1844: 1715:Leopold Freund 1695: 1692: 1688:committed dose 1683: 1682: 1674:alpha particle 1640: 1624: 1609: 1592: 1589: 1586: 1585: 1582: 1579: 1573: 1572: 1569: 1566: 1559: 1558: 1555: 1552: 1551:(bone density) 1545: 1544: 1541: 1538: 1532: 1531: 1528: 1525: 1523:CT angiography 1518: 1517: 1514: 1511: 1506: 1500: 1499: 1496: 1493: 1489: 1488: 1485: 1482: 1477: 1471: 1470: 1467: 1464: 1458: 1457: 1454: 1451: 1445: 1444: 1441: 1438: 1432: 1431: 1428: 1425: 1419: 1418: 1415: 1412: 1405: 1404: 1401: 1398: 1394: 1393: 1390: 1387: 1382: 1378: 1377: 1374: 1371: 1365: 1364: 1361: 1358: 1353: 1349: 1348: 1345: 1342: 1336: 1335: 1332: 1329: 1325: 1324: 1321: 1318: 1313: 1309: 1308: 1305: 1302: 1295: 1294: 1291: 1288: 1285: 1283:CT of the head 1279: 1278: 1272: 1269: 1266: 1262: 1261: 1258: 1257: 1250: 1243: 1235: 1233: 1227: 1224: 1208: 1207: 1203: 1200:committed dose 1184: 1178: 1148: 1145: 1143: 1140: 1139: 1138: 1132: 1125: 1118: 1112: 1105: 1099: 1081: 1078: 1055:effective dose 1050: 1009: 1006: 1001:committed dose 989:effective dose 981:health physics 968: 965: 930: 929: 926: 919: 918:16 to 25 weeks 916: 915:18 to 27 weeks 912: 911: 908: 902: 899: 898:10 to 17 weeks 895: 894: 891: 885: 884: 881: 875: 872: 868: 867: 864: 858: 855: 851: 850: 843: 840: 835: 795: 792: 762: 759: 756: 755: 749: 748: 747:1–2 days 745: 742: 741:2–4 weeks 739: 738:4–6 weeks 736: 735:6–8 weeks 733: 729: 728: 725: 722: 719: 716: 713: 709: 708: 705: 702: 699: 696: 693: 690: 684: 683: 680: 655: 645:disorientation 621: 595: 581: 579: 571: 570: 567: 564: 561: 560:7–28 days 558: 555: 553: 545: 544: 527: 524: 521: 518: 517:No impairment 515: 508: 507: 506:< 1 h 504: 501: 498: 495: 492: 486: 485: 484:Severe (100%) 482: 479: 476: 473: 470: 464: 463: 462:< 1 h 460: 457: 454: 451: 448: 442: 441: 440:Severe (100%) 438: 435: 434:Moderate (80%) 432: 429: 426: 420: 419: 418:< 1 h 416: 413: 410: 407: 404: 398: 397: 394: 391: 388: 385: 382: 376: 375: 372: 371:< 48 h 369: 368:< 48 h 366: 363: 362:< 24 h 360: 354: 353: 350: 347: 346:10–60 min 344: 341: 338: 332: 331: 328: 325: 322: 319: 316: 307: 301: 300: 294: 288: 282: 276: 269: 268: 257: 254: 244: 243: 237: 227: 221: 212: 206: 192:threshold dose 178: 175: 107: 104: 103: 102: 98: 88:thyrotoxicosis 79: 78:Health effects 76: 48:thyrotoxicosis 15: 13: 10: 9: 6: 4: 3: 2: 4067: 4056: 4053: 4051: 4048: 4046: 4043: 4042: 4040: 4026: 4022: 4018: 4017:Radioactivity 4014: 4010: 4003: 3997: 3994: 3992: 3989: 3988: 3986: 3982: 3976: 3973: 3971: 3968: 3966: 3963: 3961: 3958: 3957: 3955: 3951: 3945: 3942: 3940: 3937: 3935: 3932: 3930: 3927: 3925: 3922: 3920: 3917: 3915: 3912: 3910: 3907: 3906: 3904: 3902:Organisations 3900: 3894: 3891: 3889: 3886: 3884: 3881: 3879: 3876: 3874: 3871: 3870: 3868: 3864: 3858: 3855: 3853: 3850: 3848: 3845: 3843: 3840: 3839: 3836: 3833: 3831: 3828: 3826: 3823: 3821: 3818: 3816: 3813: 3811: 3808: 3807: 3805: 3799: 3793: 3790: 3788: 3785: 3783: 3780: 3778: 3775: 3773: 3770: 3768: 3765: 3763: 3760: 3758: 3755: 3753: 3750: 3748: 3745: 3743: 3740: 3738: 3735: 3733: 3730: 3728: 3727:Absorbed dose 3725: 3724: 3722: 3716: 3710: 3707: 3705: 3702: 3700: 3697: 3695: 3692: 3690: 3687: 3685: 3682: 3680: 3677: 3675: 3672: 3671: 3669: 3667:Main articles 3665: 3661: 3654: 3649: 3647: 3642: 3640: 3635: 3634: 3631: 3620: 3616: 3612: 3611:Radioactivity 3608: 3601: 3595: 3592: 3590: 3587: 3585: 3582: 3580: 3577: 3575: 3572: 3571: 3569: 3565: 3559: 3556: 3554: 3551: 3549: 3546: 3544: 3541: 3539: 3536: 3535: 3533: 3529: 3523: 3520: 3518: 3515: 3513: 3510: 3508: 3505: 3503: 3500: 3498: 3495: 3493: 3490: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3470: 3468: 3465: 3463: 3460: 3458: 3455: 3453: 3450: 3448: 3445: 3443: 3440: 3436: 3433: 3431: 3428: 3427: 3425: 3424: 3422: 3416: 3406: 3403: 3401: 3398: 3396: 3393: 3391: 3388: 3386: 3383: 3381: 3378: 3376: 3373: 3371: 3368: 3366: 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3343: 3341: 3338: 3337: 3334: 3328: 3325: 3323: 3320: 3318: 3315: 3313: 3310: 3308: 3305: 3303: 3300: 3298: 3295: 3293: 3290: 3288: 3285: 3283: 3280: 3278: 3277:Beta particle 3275: 3273: 3270: 3268: 3265: 3263: 3262:Cluster decay 3260: 3258: 3255: 3254: 3252: 3250: 3246: 3240: 3237: 3235: 3232: 3230: 3227: 3225: 3222: 3220: 3217: 3215: 3212: 3210: 3207: 3205: 3202: 3201: 3199: 3197: 3193: 3190: 3188:Main articles 3186: 3181: 3174: 3169: 3167: 3162: 3160: 3155: 3154: 3151: 3145: 3142: 3139: 3136: 3132: 3131: 3127: 3122: 3118: 3117: 3113: 3102: 3098: 3094: 3090: 3086: 3082: 3078: 3074: 3070: 3063: 3056: 3053: 3040: 3039:Science Daily 3036: 3030: 3027: 3022: 3016: 3012: 3005: 3002: 2990: 2986: 2982: 2978: 2974: 2973: 2965: 2962: 2950: 2945: 2937: 2934: 2928: 2923: 2919: 2915: 2911: 2907: 2903: 2899: 2895: 2888: 2885: 2880: 2878:9781001281377 2874: 2870: 2869: 2864: 2858: 2855: 2843: 2839: 2836: 2830: 2827: 2822: 2818: 2814: 2810: 2806: 2802: 2798: 2794: 2789: 2781: 2778: 2774: 2773:9781600212802 2770: 2766: 2760: 2757: 2752: 2748: 2744: 2740: 2736: 2732: 2727: 2719: 2716: 2711: 2707: 2702: 2697: 2693: 2689: 2684: 2679: 2675: 2671: 2668:(6): e99112. 2667: 2663: 2659: 2652: 2649: 2644: 2640: 2635: 2630: 2626: 2622: 2618: 2614: 2610: 2606: 2602: 2595: 2592: 2580: 2579: 2575: 2570: 2561: 2559: 2555: 2551: 2546: 2543: 2539: 2534: 2531: 2527: 2522: 2519: 2514: 2510: 2505: 2500: 2496: 2492: 2487: 2482: 2478: 2474: 2470: 2463: 2460: 2454: 2453: 2448: 2442: 2440: 2438: 2436: 2434: 2432: 2430: 2426: 2421: 2417: 2412: 2407: 2403: 2399: 2394: 2389: 2385: 2381: 2377: 2370: 2367: 2362: 2358: 2353: 2348: 2344: 2340: 2335: 2330: 2326: 2322: 2318: 2311: 2308: 2296: 2292: 2286: 2283: 2271: 2265: 2261: 2257: 2252: 2251: 2242: 2239: 2225: 2220: 2213: 2210: 2206: 2201: 2198: 2192: 2188: 2184: 2180: 2176: 2172: 2167: 2159: 2157: 2155: 2151: 2147: 2142: 2139: 2133: 2129: 2126: 2124: 2121: 2119: 2116: 2114: 2111: 2109: 2106: 2104: 2101: 2099: 2096: 2094: 2091: 2090: 2086: 2081: 2077: 2074: 2070: 2066: 2062: 2058: 2055: 2051: 2047: 2043: 2042: 2041: 2035: 2031: 2027: 2023: 2020: 2017: 2016:Bioenergetics 2014: 2011: 2007: 2003: 2002:Embryogenesis 2000: 1997: 1993: 1990: 1987: 1984: 1982: 1981:Radiogenomics 1979: 1977: 1974: 1972: 1969: 1966: 1962: 1959: 1957: 1953: 1950:imaging) and 1949: 1945: 1941: 1938: 1935: 1932: 1929: 1925: 1922: 1920: 1917: 1914: 1910: 1906: 1903: 1901: 1898: 1895: 1892: 1890: 1886: 1884: 1880: 1877: 1875: 1872: 1870: 1866: 1863: 1861: 1858: 1856: 1853: 1852: 1851: 1845: 1843: 1840: 1836: 1831: 1829: 1824: 1819: 1817: 1813: 1809: 1805: 1801: 1797: 1793: 1788: 1785: 1781: 1777: 1773: 1769: 1765: 1761: 1756: 1754: 1749: 1747: 1743: 1738: 1736: 1732: 1728: 1724: 1720: 1716: 1711: 1709: 1705: 1701: 1693: 1691: 1689: 1680: 1675: 1672: 1668: 1664: 1660: 1656: 1652: 1648: 1644: 1641: 1638: 1634: 1629: 1625: 1622: 1618: 1614: 1610: 1607: 1603: 1599: 1598: 1597: 1590: 1583: 1580: 1578: 1574: 1570: 1567: 1564: 1560: 1556: 1553: 1550: 1546: 1542: 1539: 1537: 1533: 1529: 1527:0.3 - 1.6 mSv 1526: 1524: 1520: 1519: 1515: 1512: 1510: 1507: 1505: 1501: 1497: 1494: 1491: 1490: 1486: 1483: 1481: 1478: 1476: 1472: 1468: 1465: 1463: 1460: 1459: 1455: 1452: 1450: 1447: 1446: 1442: 1439: 1437: 1434: 1433: 1429: 1426: 1424: 1421: 1420: 1416: 1413: 1411: 1410:radiocontrast 1407: 1406: 1402: 1399: 1396: 1395: 1391: 1388: 1386: 1383: 1379: 1375: 1372: 1370: 1367: 1366: 1362: 1359: 1357: 1354: 1350: 1346: 1343: 1341: 1338: 1337: 1333: 1330: 1327: 1326: 1322: 1319: 1317: 1314: 1310: 1306: 1303: 1301: 1300:radiocontrast 1297: 1296: 1292: 1289: 1287:Single series 1286: 1284: 1280: 1277: 1273: 1270: 1267: 1265:Target organs 1264: 1263: 1256: 1251: 1249: 1244: 1242: 1237: 1236: 1231: 1225: 1223: 1221: 1217: 1213: 1204: 1201: 1197: 1196:brachytherapy 1193: 1189: 1185: 1183: 1179: 1177:in his pocket 1176: 1172: 1171: 1170: 1161: 1153: 1146: 1141: 1136: 1133: 1130: 1126: 1123: 1119: 1117: 1113: 1110: 1106: 1103: 1100: 1097: 1094: 1093: 1092: 1089: 1087: 1080:Organizations 1079: 1077: 1075: 1071: 1067: 1063: 1059: 1056: 1049: 1046: 1041: 1039: 1035: 1031: 1027: 1023: 1019: 1015: 1014:absorbed dose 1007: 1005: 1002: 997: 994: 990: 986: 982: 978: 973: 966: 964: 962: 961:breast cancer 959: 954: 952: 948: 944: 939: 937: 927: 924: 920: 917: 914: 913: 909: 907: 903: 901:8 to 15 weeks 900: 897: 896: 892: 890: 887: 886: 882: 880: 879:birth defects 876: 871:4 to 10 weeks 869: 865: 862: 859: 856: 853: 852: 848: 844: 841: 839: 838:Embryonic age 836: 834: 831: 830: 827: 825: 821: 817: 813: 809: 808:birth defects 806:, structural 805: 800: 793: 788: 783: 779: 776: 772: 768: 760: 754: 750: 746: 743: 740: 737: 734: 731: 730: 726: 723: 720: 717: 714: 711: 710: 706: 703: 700: 697: 694: 691: 689: 685: 681: 679: 675: 671: 667: 663: 659: 656: 654: 650: 646: 642: 638: 634: 630: 626: 622: 620: 617:after 3  616: 612: 608: 604: 600: 596: 594: 590: 586: 582: 580: 578: 577: 573: 572: 568: 565: 562: 559: 556: 554: 552: 551: 550:Latent period 547: 546: 543: 539: 535: 531: 528: 525: 522: 519: 516: 513: 510: 509: 505: 503:< 1 h 502: 500:< 1 h 499: 496: 493: 491: 490:Time of onset 488: 487: 483: 481:Severe (100%) 480: 477: 474: 471: 469: 466: 465: 461: 458: 455: 452: 449: 447: 446:Time of onset 444: 443: 439: 436: 433: 430: 427: 425: 422: 421: 417: 415:< 1 h 414: 411: 408: 405: 403: 402:Time of onset 400: 399: 396:Heavy (100%) 395: 392: 389: 386: 383: 381: 378: 377: 373: 370: 367: 364: 361: 359: 356: 355: 351: 348: 345: 342: 339: 337: 336:Time of onset 334: 333: 329: 326: 323: 320: 317: 315: 311: 308: 306: 302: 299: 296:> 30  295: 293: 289: 287: 283: 281: 277: 275: 271: 270: 266: 262: 261:absorbed dose 251: 248: 241: 238: 235: 231: 228: 225: 222: 220: 216: 213: 210: 207: 204: 201: 200: 199: 195: 193: 189: 188:Deterministic 184: 177:Deterministic 176: 174: 172: 167: 165: 161: 155: 153: 149: 145: 141: 136: 131: 129: 128:heart disease 125: 121: 120:teratogenesis 117: 113: 105: 99: 96: 95: 94: 91: 89: 85: 77: 75: 73: 69: 65: 61: 57: 56:latent period 53: 49: 45: 41: 37: 33: 29: 28:actinobiology 25: 21: 4045:Radiobiology 4021:Radiobiology 3852:Survey meter 3772:Monitor unit 3718:Measurement 3709:Radiobiology 3708: 3615:Radiobiology 3497:Radiobiology 3496: 3457:Laser safety 3134: 3119:ICRP, 2007. 3101:the original 3072: 3068: 3055: 3043:. Retrieved 3038: 3029: 3010: 3004: 2992:. Retrieved 2971: 2964: 2952:. Retrieved 2948: 2936: 2901: 2897: 2887: 2867: 2863:Lea, Douglas 2857: 2845:. Retrieved 2841: 2829: 2796: 2792: 2780: 2764: 2759: 2734: 2730: 2718: 2665: 2661: 2651: 2608: 2604: 2594: 2582:. Retrieved 2572: 2545: 2533: 2521: 2476: 2472: 2462: 2450: 2383: 2379: 2369: 2324: 2320: 2310: 2298:. Retrieved 2294: 2285: 2273:. Retrieved 2249: 2241: 2228:. Retrieved 2223: 2212: 2200: 2174: 2170: 2141: 2048:, typically 2039: 1940:Biomagnetism 1896:of organisms 1869:cell biology 1849: 1832: 1820: 1792:Radium Girls 1789: 1757: 1750: 1739: 1712: 1708:free radical 1697: 1684: 1662: 1658: 1605: 1602:potassium-40 1594: 1536:Dental X-ray 1211: 1209: 1167: 1090: 1083: 1057: 1047: 1042: 1017: 1011: 998: 974: 970: 955: 940: 933: 925:(lower risk) 874:2 to 8 weeks 857:0 to 2 weeks 854:2 to 4 weeks 801: 797: 794:In pregnancy 771:transuranics 764: 753:Table source 752: 692:Without care 687: 574: 548: 489: 445: 401: 365:24–48 h 357: 335: 304: 245: 236:to the lungs 196: 186: 168: 156: 148:linear model 132: 109: 92: 81: 72:radiotherapy 39: 27: 23: 20:Radiobiology 19: 18: 3893:Respirators 3825:Ion chamber 3239:Ultraviolet 3234:Radio waves 3133:Eric Hall, 2795:(Lecture). 2775:. 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If this 112:stochastic 106:Stochastic 3965:NRC (USA) 3914:HPS (USA) 3815:Dosimeter 3732:Becquerel 3679:Dosimetry 3574:Half-life 3447:Dosimetry 3282:Gamma ray 3229:Microwave 3219:Starlight 3180:Radiation 2821:250827449 2692:1932-6203 2625:1759-4812 2550:ICRP 2007 2538:ICRP 2007 2526:ICRP 2007 2495:1465-542X 2402:0820-3946 2343:0820-3946 2205:ICRP 2007 2146:ICRP 2007 2118:Radiology 2073:microbeam 2069:electrons 2026:Neurology 1883:apoptosis 1865:Molecular 1679:cytotoxic 1667:lithium-7 1635:within a 1554:0.001 mSv 1540:0.005 mSv 1513:0.001 mSv 1487:6 months 1381:Abdominal 1334:6 months 1293:8 months 1268:Exam type 1206:exposure. 1104:(UNSCEAR) 977:dosimetry 936:IQ points 910:60 - 310 866:50 - 100 775:actinides 712:With care 688:Mortality 641:Dizziness 514:function 305:Immediate 284:6–8  278:2–6  272:1–2  240:Cataracts 3970:ONR (UK) 3960:IRR (UK) 3939:SRP (UK) 3878:Glovebox 3782:Roentgen 3224:Sunlight 3209:Infrared 3089:11572640 2865:(1955). 2751:11749482 2710:24915439 2662:PLOS ONE 2643:27578040 2513:15642178 2420:19047611 2361:19047611 2191:24275177 2087:See also 2006:Ontogeny 1837:and the 1671:helium-4 1661:. 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Index

medical sciences
ionizing radiation
radiation therapy
thyrotoxicosis
induction of cancer
latent period
radiation burns
acute radiation syndrome
medical imaging
radiotherapy
radiation therapy
thyrotoxicosis
stochastic
Radiation-induced cancer
teratogenesis
cognitive decline
heart disease
induction of cancer
effective radiation dose
sievert
linear model
background radiation
atomic bomb survivors
radioresistance
mSv
Acute radiation syndrome
Deterministic
threshold dose
Acute radiation syndrome
Radiation burns

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