199:
1781:
415:) pathway which is responsible for formation of fructose from glucose. Aldose reductase activity is increased, parallel to glucose blood levels, in tissues that are not insulin sensitive, including lenses, peripheral nerves and renal glomeruli. Sorbitol does not diffuse through cell membranes easily and therefore accumulates in these tissues, causing osmotic damage, leading to retinopathy and neuropathy.
451:
24:
332:
424:
have effect on motor nerve function in mild to moderate DSP, but failed to show statistically significant difference in sensory nerve function. Efficacy of ranirestat was evaluated by nerve conduction studies, the modified
Toronto Clinical Neuropathy Score (mTCNS), and quantitative sensory tests (QSTs).
423:
Results from a
Canadian double-blind, placebo-controlled biopsy Phase III clinical trial, involving total of 549 patients with diabetic sensorimotor polyneuropathy (DSP) randomly assigned to treatment with placebo or 10, 20, or 40 mg/day ranirestat for 52 weeks, showed that ranirestat appears to
623:
100:
345:
1826:
616:
411:
Ranirestat is aldose reductase inhibitor that acts by reducing sorbitol accumulation in cells. Aldose reductase is an enzyme that catalyzes one of the steps in sorbitol (
609:
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1860:
1819:
1199:
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1736:
826:
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InChI=1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
1845:
232:
InChI=1/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
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has been completed. Phase III trials in Europe and the US started in June 2009 and are expected to complete in April 2013.
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487:
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1429:
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436:, also an aldose reductase inhibitor, which was withdrawn from market in 1997 due to the risk of severe liver toxicity
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790:
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Bril, V.; Hirose, T.; Tomioka, S.; Buchanan, R.; Ranirestat Study, G. (2009).
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558:"Ranirestat for the Management of Diabetic Sensorimotor Polyneuropathy"
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Except where otherwise noted, data are given for materials in their
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475:. Unsourced material may be challenged and removed.
256:c1cc2n(c1)3(CC(=O)NC3=O)C(=O)N(C2=O)Cc4ccc(cc4F)Br
144:
75:
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8:
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883:
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671:
654:
624:
610:
602:
197:
119:
15:
581:
535:Learn how and when to remove this message
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548:
391:status. The drug is to be used orally.
253:
218:
193:
375:being developed for the treatment of
225:Key: QCVNMNYRNIMDKV-QGZVFWFLSA-N
7:
1777:
1775:
644:, and other drugs used in diabetes (
473:adding citations to reliable sources
1614:Glibenclamide (glyburide)/metformin
1594:Dapagliflozin/saxagliptin/metformin
235:Key: QCVNMNYRNIMDKV-QGZVFWFLBS
135:
1861:Gastrointestinal system drug stubs
1799:. You can help Knowledge (XXG) by
14:
1779:
449:
330:
295:
292:
283:
22:
460:needs additional citations for
326:(at 25 °C , 100 kPa).
289:
301:
277:
1:
1430:Alpha-glucosidase inhibitors
49:-spiropyrazine]-1′,2,3′,5(2′
1846:Aldose reductase inhibitors
1392:Aldose reductase inhibitors
316:420.189 g/mol
1877:
1774:
1258:GLP1 poly-agonist peptides
373:aldose reductase inhibitor
1704:Sitagliptin/ertugliflozin
1699:Sitagliptin/dapagliflozin
1619:Glimepiride/rosiglitazone
1599:Empagliflozin/linagliptin
1589:Dapagliflozin/saxagliptin
1564:
1117:Glibenclamide (glyburide)
873:
862:
670:
653:
381:Dainippon Sumitomo Pharma
320:
264:
244:
209:
59:
35:
30:
21:
1791:article relating to the
1684:Pioglitazone/sitagliptin
1674:Pioglitazone/glimepiride
1664:Phenformin/sulfonylureas
1609:Gemigliptin/rosuvastatin
1579:Cagrilintide/semaglutide
1793:gastrointestinal system
1714:Sitagliptin/simvastatin
1689:Rosiglitazone/metformin
1669:Pioglitazone/alogliptin
1659:Metformin/teneligliptin
1654:Metformin/sulfonylureas
1634:Metformin/ertugliflozin
1604:Empagliflozin/metformin
1584:Dapagliflozin/metformin
1574:Canagliflozin/metformin
1200:GLP-1 receptor agonists
1719:Vildagliptin/metformin
1679:Pioglitazone/metformin
387:. It has been granted
1709:Sitagliptin/metformin
1694:Saxagliptin/metformin
1649:Metformin/repaglinide
1644:Metformin/gemigliptin
1624:Linagliptin/metformin
399:A Canadian Phase III
1639:Metformin/evogliptin
1569:Alogliptin/metformin
469:improve this article
37:Preferred IUPAC name
879:Insulin sensitizers
634:diabetes medication
407:Mechanism of action
377:diabetic neuropathy
18:
1758:Never to phase III
1629:Metformin/acarbose
979:Dual PPAR agonists
848:Never to phase III
755:Ultralente insulin
353:Infobox references
16:
1808:
1807:
1772:
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1727:
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1291:
1290:
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1037:
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857:
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820:
765:ultra-long-acting
689:Insulin glulisine
574:10.2337/dc08-2110
545:
544:
537:
519:
361:Chemical compound
359:
358:
178:CompTox Dashboard
101:Interactive image
1868:
1856:Pyrrolopyrazines
1829:
1822:
1815:
1783:
1776:
1562:
1458:SGLT2 inhibitors
1388:
1297:DPP-4 inhibitors
1278:(GLP-1/GIP/GCGR)
1254:
1060:
1048:
884:
875:
864:
773:Insulin degludec
735:Insulin glargine
672:
655:
626:
619:
612:
603:
596:
595:
585:
568:(7): 1256–1260.
553:
540:
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518:
477:
453:
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343:
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272:Chemical formula
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26:
19:
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1748:Clinical trials
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1547:
1521:
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1375:
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1252:
1190:
1161:
1055:
1033:
1006:
973:
918:/"glitazones" (
910:
869:
854:
853:
838:Clinical trials
817:
796:
777:+insulin aspart
759:
730:Insulin detemir
716:
712:Regular insulin
698:
666:
664:insulin analogs
649:
642:insulin analogs
630:
600:
599:
555:
554:
550:
541:
530:
524:
521:
478:
476:
466:
454:
443:
430:
421:
409:
397:
367:(also known as
362:
355:
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348: ?)
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12:
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5:
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1527:
1523:
1522:
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1514:
1509:
1504:
1499:
1494:
1492:Luseogliflozin
1489:
1484:
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1474:
1469:
1463:
1461:
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1453:
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1300:
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1289:
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1285:
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1225:
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1215:
1210:
1204:
1202:
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1192:
1191:
1189:
1188:
1183:
1178:
1172:
1170:
1163:
1162:
1160:
1159:
1157:Glyclopyramide
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1113:2nd generation
1109:
1108:
1103:
1098:
1093:
1088:
1086:Chlorpropamide
1083:
1078:
1072:1st generation
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1066:
1057:
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1045:
1039:
1038:
1035:
1034:
1032:
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797:
795:
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787:Insulin icodec
784:
769:
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752:
747:
742:
732:
726:
724:
718:
717:
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714:
708:
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700:
699:
697:
696:
694:Insulin lispro
691:
686:
684:Insulin aspart
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667:
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650:
631:
629:
628:
621:
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525:September 2011
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401:clinical trial
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195:DTXSID80163642
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2:
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1600:
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1587:
1585:
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1580:
1577:
1575:
1572:
1570:
1567:
1566:
1563:
1560:
1558:
1554:
1544:
1541:
1539:
1538:Bromocriptine
1536:
1534:
1531:
1530:
1528:
1524:
1518:
1517:Velagliflozin
1515:
1513:
1512:Tofogliflozin
1510:
1508:
1507:Sotagliflozin
1505:
1503:
1500:
1498:
1497:Remogliflozin
1495:
1493:
1490:
1488:
1487:Ipragliflozin
1485:
1483:
1482:Ertugliflozin
1480:
1478:
1477:Empagliflozin
1475:
1473:
1472:Dapagliflozin
1470:
1468:
1467:Canagliflozin
1465:
1464:
1462:
1460:/"gliflozins"
1459:
1455:
1449:
1446:
1444:
1441:
1439:
1436:
1435:
1433:
1431:
1427:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1397:
1395:
1393:
1389:
1386:
1382:
1372:
1369:
1367:
1364:
1362:
1361:Teneligliptin
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1303:
1301:
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1294:
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1280:
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1271:
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1261:
1259:
1255:
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1234:
1231:
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1201:
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1164:
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1135:
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1128:
1125:
1123:
1120:
1118:
1114:
1111:
1110:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1076:Acetohexamide
1073:
1070:
1069:
1067:
1065:
1064:Sulfonylureas
1061:
1058:
1056:
1049:
1046:
1044:
1043:Secretagogues
1040:
1030:
1027:
1025:
1022:
1021:
1019:
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1013:
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995:
993:
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988:
985:
984:
982:
980:
976:
970:
967:
965:
964:Rosiglitazone
962:
960:
959:Rivoglitazone
957:
955:
952:
950:
949:Netoglitazone
947:
945:
944:Lobeglitazone
942:
940:
937:
935:
932:
930:
927:
926:
924:
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917:
913:
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824:
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788:
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778:
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771:
770:
768:
766:
762:
756:
753:
751:
750:Lente insulin
748:
746:
743:
740:
739:+lixisenatide
736:
733:
731:
728:
727:
725:
723:
719:
713:
710:
709:
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705:
701:
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1851:Orphan drugs
1801:expanding it
1786:
1557:Combinations
1502:Sergliflozin
1409:
1371:Vildagliptin
1366:Trelagliptin
1346:Omarigliptin
1321:Garvagliptin
1248:Taspoglutide
1238:Orforglipron
1233:Lixisenatide
1167:Meglitinides
1122:Glibornuride
1112:
1096:Metahexamide
1091:Glycyclamide
1071:
1024:Cagrilintide
1014:analogs and
1002:Tesaglitazar
997:Saroglitazar
992:Muraglitazar
969:Troglitazone
954:Pioglitazone
934:Darglitazone
868:Non-insulins
801:
791:+semaglutide
781:+liraglutide
764:
721:
704:short-acting
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484:"Ranirestat"
479:
467:Please help
462:verification
459:
422:
410:
398:
385:PharmaKyorin
368:
364:
363:
60:Identifiers
50:
46:
42:
1744:from market
1356:Sitagliptin
1351:Saxagliptin
1341:Melogliptin
1336:Linagliptin
1331:Gosogliptin
1326:Gemigliptin
1299:/"gliptins"
1284:(GLP-1/GIP)
1282:Tirzepatide
1276:Retatrutide
1243:Semaglutide
1228:Liraglutide
1218:Dulaglutide
1213:Danuglipron
1208:Albiglutide
1186:Repaglinide
1181:Nateglinide
1176:Mitiglinide
1169:/"glinides"
1152:Glisoxepide
1137:Glimepiride
1127:Glicaramide
1106:Tolbutamide
1081:Carbutamide
1029:Pramlintide
987:Aleglitazar
939:Englitazone
929:Ciglitazone
834:from market
745:NPH insulin
722:long-acting
676:fast-acting
389:orphan drug
265:Properties
77:147254-64-6
17:Ranirestat
1840:Categories
1533:Benfluorex
1420:Zenarestat
1410:Ranirestat
1405:Fidarestat
1400:Epalrestat
1316:Evogliptin
1311:Anagliptin
1306:Alogliptin
1147:Gliquidone
1132:Gliclazide
1101:Tolazamide
906:Phenformin
888:Biguanides
495:newspapers
441:References
365:Ranirestat
312:Molar mass
166:Z26P56GFTV
112:ChemSpider
88:3D model (
67:CAS Number
1754:Phase III
1742:Withdrawn
1543:Imeglimin
1448:Voglibose
1415:Tolrestat
1266:Mazdutide
1223:Exenatide
1142:Glipizide
901:Metformin
844:Phase III
832:Withdrawn
803:inhalable
434:Tolrestat
53:)-tetrone
1443:Miglitol
1438:Acarbose
896:Buformin
660:Insulins
638:insulins
592:19366965
428:See also
419:Efficacy
371:) is an
45:)-2′--1′
1268:(GLP-1/
814:Afrezza
811:Exubera
583:2699746
509:scholar
369:AS-3201
346:what is
344: (
133:PubChem
1737:WHO-EM
1016:DACRAs
1012:Amylin
827:WHO-EM
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249:SMILES
146:153948
121:135685
31:Names
1795:is a
1787:This
1526:Other
1384:Other
632:Oral
516:JSTOR
502:books
214:InChI
90:JSmol
1797:stub
1789:drug
1270:GCGR
920:PPAR
916:TZDs
640:and
588:PMID
488:news
383:and
157:UNII
1054:ATP
646:A10
578:PMC
570:doi
471:by
379:by
183:EPA
136:CID
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