Knowledge (XXG)

Rebamipide

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Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K (November 1995). "Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine".
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Zhang S, Qing Q, Bai Y, Mao H, Zhu W, Chen Q, Zhang Y, Chen Y (July 2013). "Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis".
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Tarnawski AS, Chai J, Pai R, Chiou SK (February 2004). "Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?".
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Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A (September 1998). "Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing".
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InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)
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Gagliano-Jucá T, Moreno RA, Zaminelli T, Napolitano M, Magalhães AF, Carvalhaes A, Trevisan MS, Wallace JL, De Nucci G (June 2016).
474: 1249: 926: 157: 283: 1309: 343: 1397: 805:"Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial" 673:
Takumida M, Anniko M (January 2009). "Radical scavengers for elderly patients with age-related hearing loss".
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mucosa, and more recently, the small intestine, but not for naproxen-induced gastric damage.
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Studies have shown that rebamipide can fight the damaging effects of
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Rebamipide is used in a number of Asian countries including
348: 538:. It works by enhancing mucosal defense, scavenging free 1352: 505: 1237: 1126: 1090: 1020: 991: 938: 428: 415: 379: 374: 342: 322: 302: 282: 262: 242: 231: 222: 197: 177: 148: 123: 107: 89: 40: 35: 875:(in Russian). Russian State Register of Medicines 211: 462:Clc1ccc(cc1)C(=O)NC(C(=O)O)CC2=CC(=O)Nc3ccccc32 186: 1372: 1245:Bismuth subcitrate/metronidazole/tetracycline 906: 8: 542:, and temporarily activating genes encoding 19: 1379: 1365: 913: 899: 891: 362: 271: 830: 820: 291: 594: 479: 459: 358: 251: 162: 18: 1260:Vonoprazan/amoxicillin/clarithromycin 331: 99: 7: 1329: 1327: 136: 311: 202: 1418:Gastrointestinal system drug stubs 1351:. You can help Knowledge (XXG) by 730:10.1023/b:ddas.0000017439.60943.5c 14: 1331: 1250:Omeprazole/amoxicillin/rifabutin 400: 397: 391: 27: 762:Digestive Diseases and Sciences 718:Digestive Diseases and Sciences 632:Digestive Diseases and Sciences 604:Digestive Diseases and Sciences 487:Key:ALLWOAVDORUJLA-UHFFFAOYSA-N 585:under the brand name Rebagit. 406: 385: 1: 169:-quinolin-4-yl)propanoic acid 526:)-quinolinone, is used for 1434: 1326: 375:Chemical and physical data 1287: 1268: 822:10.1186/s12876-016-0472-x 774:10.1007/s10620-013-2606-0 687:10.1080/00016480802008215 495: 470: 450: 153: 26: 1413:4-Chlorophenyl compounds 1343:article relating to the 101:International Drug Names 1345:gastrointestinal system 968:Lavoltidine (loxtidine) 569:(marketed as Mucosta), 530:protection, healing of 1255:Vonoprazan/amoxicillin 1092:Potassium-competitive 1022:Proton-pump inhibitors 675:Acta Oto-Laryngologica 1278:eradication protocols 1134:Aceglutamide aluminum 532:gastroduodenal ulcers 16:Amino acid derivative 1149:Arbaclofen placarbil 809:BMC Gastroenterology 1276:Helicobacter pylori 610:(9 Suppl): 5S–13S. 534:, and treatment of 23: 1314:Never to phase III 1154:Bismuth subcitrate 644:10.1007/bf02063257 522:derivative of 2-(1 1398:Alpha-Amino acids 1360: 1359: 1324: 1323: 513: 512: 441:Interactive image 344:CompTox Dashboard 85: 77: 69: 53: 1425: 1381: 1374: 1367: 1335: 1328: 1224:Zinc L-carnosine 915: 908: 901: 892: 885: 884: 882: 880: 869: 863: 862: 851: 845: 844: 834: 824: 800: 794: 793: 768:(7): 1991–2000. 756: 750: 749: 713: 707: 706: 670: 664: 663: 626: 620: 619: 599: 544:cyclooxygenase-2 509: 508: 501: 443: 423: 408: 402: 399: 393: 387: 367: 366: 352: 350: 335: 315: 295: 275: 255: 235: 215: 205: 204: 190: 140: 103: 79: 71: 55: 47: 31: 24: 22: 1433: 1432: 1428: 1427: 1426: 1424: 1423: 1422: 1388: 1387: 1386: 1385: 1325: 1320: 1319: 1304:Clinical trials 1283: 1264: 1233: 1122: 1093: 1086: 1037:Dexlansoprazole 1024: 1016: 996: 987: 943: 934: 919: 889: 888: 878: 876: 871: 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1204:Sulglicotide 1193: 1144:Alginic acid 1062:Pantoprazole 1052:Lansoprazole 1042:Esomeprazole 1032:Azeloprazole 1025:("-prazole") 923:peptic ulcer 877:. Retrieved 867: 858: 855:"Rebamipide" 849: 812: 808: 798: 765: 761: 754: 724:(2): 202–9. 721: 717: 711: 681:(1): 36–44. 678: 674: 668: 635: 631: 624: 607: 603: 597: 564: 561:Availability 548: 523: 515: 514: 503:   497:   166: 1300:from market 1209:Telenzepine 1184:Pirenzepine 1179:Lesogaberan 1174:Irsogladine 1139:Acetoxolone 1096:("-prazan") 1082:Timoprazole 1072:Rabeprazole 1067:Picoprazole 1007:Misoprostol 1000:("-prost-") 946:("-tidine") 944:antagonists 571:South Korea 424: g·mol 149:Identifiers 42:Trade names 1408:Benzamides 1392:Categories 1273:See also: 1229:Zolimidine 1199:Sucralfate 1194:Rebamipide 1189:Proglumide 1118:Vonoprazan 1113:Soraprazan 1108:Revaprazan 1103:Linaprazan 1057:Omeprazole 1047:Ilaprazole 983:Roxatidine 978:Ranitidine 973:Nizatidine 963:Lafutidine 958:Famotidine 953:Cimetidine 921:Drugs for 589:References 520:amino acid 516:Rebamipide 429:3D model ( 417:Molar mass 293:LR583V32ZR 264:ChemSpider 224:IUPHAR/BPS 188:90098-04-7 179:CAS Number 158:IUPAC name 115:By mouth ( 78:, Rebamax 70:, Rebagit 54:, Rebagen 21:Rebamipide 1310:Phase III 1298:Withdrawn 1219:Troxipide 1214:Teprenone 1169:Gefarnate 1164:Cetraxate 1012:Enprostil 998:analogues 927:GERD/GORD 859:Drugs.com 815:(1): 58. 536:gastritis 109:Routes of 95:Drugs.com 841:27259970 782:23456504 746:31756608 738:15104358 703:16906464 695:18607930 660:22807270 540:radicals 506:(verify) 244:DrugBank 125:ATC code 46:Mucosta 879:10 June 832:4893238 790:4887031 652:7587834 616:9753220 553:on the 528:mucosal 381:Formula 253:DB11656 199:PubChem 141:) 135: ( 133:A02BX14 117:tablets 1293:WHO-EM 1127:Others 839:  829:  788:  780:  744:  736:  701:  693:  658:  650:  614:  583:Russia 551:NSAIDs 455:SMILES 422:370.79 324:ChEMBL 313:D01121 1347:is a 1339:This 786:S2CID 742:S2CID 699:S2CID 656:S2CID 579:India 575:China 567:Japan 518:, an 475:InChI 431:JSmol 1349:stub 1341:drug 995:(E)/ 931:A02B 925:and 881:2017 837:PMID 778:PMID 734:PMID 691:PMID 648:PMID 612:PMID 577:and 304:KEGG 284:UNII 273:4866 213:5042 91:AHFS 827:PMC 817:doi 770:doi 726:doi 683:doi 679:129 640:doi 555:GIT 349:EPA 233:871 203:CID 138:WHO 1394:: 1306:: 857:. 835:. 825:. 813:16 811:. 807:. 784:. 776:. 766:58 764:. 740:. 732:. 722:49 720:. 697:. 689:. 677:. 654:. 646:. 636:40 634:. 608:43 606:. 573:, 546:. 398:Cl 395:15 389:19 82:ID 74:RU 66:IN 64:, 62:CN 60:, 58:KR 50:JP 1380:e 1373:t 1366:v 1355:. 942:2 940:H 933:) 929:( 914:e 907:t 900:v 883:. 861:. 843:. 819:: 792:. 772:: 748:. 728:: 705:. 685:: 662:. 642:: 618:. 524:H 433:) 410:4 407:O 404:2 401:N 392:H 386:C 351:) 347:( 167:H 119:) 93:/ 84:) 80:( 76:) 72:( 68:) 56:( 52:) 48:(

Index


Trade names
JP
KR
CN
IN
RU
ID
AHFS
Drugs.com
International Drug Names
Routes of
administration

tablets
ATC code
A02BX14
WHO
IUPAC name
CAS Number
90098-04-7
PubChem
5042
IUPHAR/BPS
871
DrugBank
DB11656
ChemSpider
4866
UNII
LR583V32ZR
KEGG

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