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Rebecca Lancefield

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42: 385:, Lancefield served on the Commission on Streptococcal and Staphylococcal Diseases of the Armed Forces Epidemiological Board. In 1946, Lancefield was promoted to associate member at Rockefeller University. She was promoted to full member and professor at Rockefeller in 1958. Lancefield was a long-time collaborator of 334:
Lancefield's first co-authored paper was published in 1919 when she was a technician, an unusual recognition at the time. Previous to this work, researchers did not know if different streptococcal strains were biologically distinct. Working with Avery and Dochez, she identified four serological types
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After her PhD, Lancefield returned to studying β-hemolytic streptococci at Rockefeller. She now aimed to identify the biological components of surface antigens located on the bacteria. In 1928, Lancefield reported that the type-specific antigen of streptococci was a protein. She named this protein
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Lancefield discovered two additional group A streptococci surface proteins: the T-antigen, in 1940, and the R-antigen, in 1957. Later in her career, she focused on group B streptococci. Her research revealed that group B streptococci lacked the M-protein. She discovered that, instead, surface
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The Lancefield International Symposium on Streptococci and Streptococcal Diseases is named in her honor. The samples collected over her career are now maintained by Rockefeller University as the Lancefield collection. To date, the collection includes over 6,000 streptococci strains.
346:. Zinsser did not want to work with women, and suggested she move her work to the lab of Homer Swift. Therefore, the majority of her work was carried out at Rockefeller, where Swift's lab was located. At the time, viridans streptococci were incorrectly believed to contribute to 312:, and continued to study bacteriology. Lancefield received her master's degree from Columbia in 1918. The same year, she married Donald E. Lancefield, a fellow graduate student in genetics at Columbia. After graduation, she worked as a technician for 813: 362:, which she named the C-carbohydrate. Within this discovery, Lancefield revealed that the C-carbohydrate was not species-specific, as originally thought. This realization prompted her development of a classification system, called 247:(now Rockefeller University) in New York in 1918, and was associated with that institute throughout her long and outstanding career. Her bibliography comprises more than 50 publications published over 60 years. 806: 799: 421:
by Rockefeller University. She was formally honored by Wellesley College, her alma mater, in 1976. Lancefield received many awards, including the T. Duckett Jones Award of the
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Due to Lancefield's willingness to answer microbiological questions, her lab at Rockefeller earned the nickname "the Scotland Yard of streptococcal mysteries."
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because a matt colony occurs when the bacteria is exposed to the antigen. Lancefield discovered that the group-specific antigen of streptococci was composed of
1685: 1650: 1700: 1680: 576: 410: 406: 1705: 1675: 1695: 1670: 1660: 822: 483: 1665: 371: 367: 1469: 560: 1337: 308:, she taught math and science at a girls school in Vermont for one year. She accepted a scholarship to Teachers' College, 1463: 1296: 914: 430: 422: 414: 138: 1123: 426: 1522: 878: 836: 355: 755: 255: 1081: 962: 735: 920: 1373: 1141: 1045: 980: 932: 1534: 1212: 986: 956: 938: 41: 1528: 1516: 1421: 1361: 1331: 1325: 1290: 1164: 1099: 926: 244: 182: 1302: 1343: 1272: 1254: 1194: 1188: 1093: 1015: 974: 944: 902: 860: 624: 598: 339: 322: 1570: 1558: 1308: 791: 1690: 1645: 1640: 1576: 1552: 1367: 1278: 1260: 1236: 1218: 1200: 1069: 1063: 1057: 1027: 1009: 950: 908: 890: 848: 670: 1588: 1612: 1606: 1427: 1409: 1075: 884: 842: 363: 309: 262: 113: 99: 1594: 1498: 1492: 1486: 1439: 1385: 1379: 1129: 1033: 968: 896: 866: 390: 1230: 1051: 872: 706: 688: 572: 541: 418: 301: 93: 490: 1451: 1397: 1176: 1135: 1039: 696: 678: 531: 523: 297: 195: 17: 374:
for bovine streptococcal infections. Today, Lancefield groups includes groups A through M.
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that classified 70 percent of the β-hemolytic streptococcal strains they were studying.
1546: 1540: 1457: 1403: 1391: 1349: 1284: 1266: 1224: 1182: 1021: 854: 701: 658: 536: 511: 447: 386: 289: 240: 1634: 1618: 1564: 1445: 1355: 1170: 1147: 293: 258: 237: 1510: 1433: 1248: 1087: 1003: 771: 512:"A serological differentiation of human and other groups of hemolytic streptococci" 394: 382: 359: 343: 313: 266: 213: 200: 161: 772:"The Rockefeller University " The Lancefield Collection of Streptococcus Strains" 1600: 1206: 1117: 1111: 280:. She is also responsible for the serological typing of Group A Streptococci. 166: 692: 277: 710: 659:"Non-Disjunction and the Chromosome Relationships of Drosophila willistoni" 545: 683: 527: 320:
at Rockefeller. The following year, she returned to Columbia to study on
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has been used by her fellow scientists for decades and was published on
300:. Her father was an officer in the US Army Engineer Corps. She attended 305: 273: 442: 495:. Washington, D.C.: National Academy of Sciences. pp. 225–246. 795: 413:, the first woman to hold the position. She was elected to the 405:
In 1943, she was the second woman to become president of the
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polysaccharides were responsible for their virulence factor.
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in Massachusetts. After graduating in 1916 with a degree in
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Lancefield, Rebecca C.; Metz, Charles W. (1921-08-01).
366:, for streptococcal diseases. She initially designated 625:"Rebecca Craighill Lancefield: Pioneer Microbiologist" 599:"Rebecca Craighill Lancefield, Pioneer Microbiologist" 736:"PI in the Scotland Yard of Streptococcal Mysteries" 350:. Lancefield's thesis work helped dispel this idea. 1479: 1318: 1157: 996: 829: 823:
Presidents of the American Society for Microbiology
206: 194: 175: 154: 127: 119: 109: 86: 78: 66: 51: 32: 236:(January 5, 1895 – March 3, 1981) was a prominent 505: 503: 663:Proceedings of the National Academy of Sciences 571:(4th ed.). Univ of Texas Medical Branch. 417:in 1970. In 1973, she was awarded an honorary 807: 8: 632:ASM (American Society for Microbiology) News 814: 800: 792: 342:. Lancefield originally joined the lab of 245:Rockefeller Institute for Medical Research 40: 29: 743:The American Association of Immunologists 700: 682: 535: 756:"Dr. Rebecca Lancefield's Eggnog Recipe" 484:"Rebecca Craighill Lancefield 1895–1981" 429:Achievement Award, and the Medal of the 467: 409:. In 1961, she became president of the 370:for human streptococcal infections and 338:For her PhD thesis, Lancefield studied 1656:20th-century American women scientists 411:American Association of Immunologists 7: 730: 728: 726: 724: 722: 720: 592: 590: 588: 477: 475: 473: 471: 407:Society of American Bacteriologists 27:American microbiologist (1895–1981) 563:. In Baron S; et al. (eds.). 25: 250:Lancefield is best known for her 1686:Scientists from New York (state) 1651:20th-century American biologists 393:, two recipients of the notable 1701:American women microbiologists 1681:Rockefeller University faculty 1: 1338:Aaron Frederick Rasmussen Jr. 623:O'Hern, Elizabeth M. (1975). 1297:Robert George Everitt Murray 1106:Rebecca Craighill Lancefield 915:Charles-Edward Amory Winslow 569:Baron's Medical Microbiology 431:New York Academy of Medicine 423:Helen Hay Whitney Foundation 415:National Academy of Sciences 234:Rebecca Craighill Lancefield 207:Other academic advisors 139:New York Academy of Medicine 34:Rebecca Craighill Lancefield 18:Rebecca Craighill Lancefield 1722: 597:O'Hern, Elizabeth (1975). 427:American Heart Association 1706:Graduate Women in Science 1676:People from Staten Island 1183:Cornelis Bernard van Niel 837:William Thompson Sedgwick 227: 147: 39: 1696:Wellesley College alumni 1671:American microbiologists 1661:American bacteriologists 1082:Arthur Trautwein Henrici 963:Francis Charles Harrison 441:Lancefield's recipe for 284:Early life and education 265:, which is based on the 1398:Barbara Hotham Iglewski 1142:William McDowell Hammon 1046:William Mansfield Clark 933:Thomas Jonathan Burrill 921:Charles Edward Marshall 326:under Charles W. Metz. 288:Lancefield was born at 1666:American immunologists 1529:Clifford Wayne Houston 1416:Joan Wennstrom Bennett 1374:Robert Pierce Williams 1362:Frederick C. Neidhardt 1332:Harlyn Odell Halvorson 1326:Helen Riaboff Whiteley 1165:Walter James Nungester 1100:Selman Abraham Waksman 981:Arthur Parker Hitchens 927:David Hendricks Bergey 510:Lancefield RC (1933). 259:streptococcal bacteria 183:Rockefeller University 134:T. Duckett Jones Award 1344:Edwin Herman Lennette 1285:Robert Edward Hungate 1273:Dennis Wallace Watson 1267:Salvador Edward Luria 1255:Riley Dee Housewright 1213:Philip Rarick Edwards 1195:Charles Arthur Stuart 1189:Halvor Orin Halvorson 1094:Oswald Theodore Avery 1052:Milton Joseph Rosenau 1016:Alice Catherine Evans 987:Norman MacLeod Harris 975:Edwin George Hastings 957:Charles Krumwiede Jr. 945:Robert Earle Buchanan 939:Leo Frederick Rettger 903:Frederic Poole Gorham 861:Frederick George Novy 559:Patterson MJ (1996). 340:viridans streptococci 323:Drosophila willistoni 1517:Stanley Robert Maloy 1422:Richard Lane Crowell 1404:Alice Shih-Hou Huang 1368:John Charles Sherris 1291:Morris Frank Shaffer 1279:Edwin Michael Foster 1261:William Bowen Sarles 1237:Robert Lyman Starkey 1219:Charles Albert Evans 1201:Perry William Wilson 1070:James Morgan Sherman 1064:Thomas Milton Rivers 1058:Karl Friedrich Meyer 1028:Stanhope Bayne-Jones 1010:Robert Stanley Breed 951:Samuel Cate Prescott 909:William Hallock Park 891:Joseph James Kinyoun 849:Herbert William Conn 684:10.1073/pnas.7.8.225 528:10.1084/jem.57.4.571 492:Biographical Memoirs 254:classification of β- 1303:Linzy Leon Campbell 1076:Paul Franklin Clark 885:Harry Luman Russell 843:William Henry Welch 776:lab.rockefeller.edu 675:1921PNAS....7..225L 364:Lancefield grouping 330:Career and research 310:Columbia University 263:Lancefield grouping 187:Columbia University 114:Lancefield grouping 100:Columbia University 1493:Abigail A. Salyers 1440:David Schlessinger 1386:Moselio Schaechter 1380:Rita Rossi Colwell 1130:Thomas Francis Jr. 1034:James Howard Brown 969:Lore Alford Rogers 897:Veranus Alva Moore 867:Edwin Oakes Jordan 46:Lancefield in 1960 1628: 1627: 1571:Jeffery F. Miller 1559:Jeffery F. Miller 1535:Alison D. O'Brien 1243:John Roger Porter 1231:John Edward Blair 873:Erwin Frink Smith 578:978-0-9631172-1-2 419:Doctor of Science 302:Wellesley College 243:. She joined the 231: 230: 149:Scientific career 123:Donald Lancefield 94:Wellesley College 16:(Redirected from 1713: 1523:Diane E. Griffin 1452:Kenneth I. Berns 1309:Philipp Gerhardt 1177:Gail Monroe Dack 1136:Harold Joel Conn 1040:Edwin Broun Fred 816: 809: 802: 793: 786: 785: 783: 782: 768: 762: 753: 747: 746: 740: 732: 715: 714: 704: 686: 654: 648: 647: 645: 643: 629: 620: 614: 613: 603: 594: 583: 582: 556: 550: 549: 539: 507: 498: 496: 488: 482:Maclyn McCarty. 479: 437:Death and legacy 389:and a mentor of 196:Doctoral advisor 102:(M.S. & PhD) 73: 61: 59: 44: 30: 21: 1721: 1720: 1716: 1715: 1714: 1712: 1711: 1710: 1631: 1630: 1629: 1624: 1583:Lynn W. Enquist 1577:Timothy Donohue 1553:David C. Hooper 1505:Thomas E. Shenk 1475: 1314: 1153: 992: 825: 820: 790: 789: 780: 778: 770: 769: 765: 754: 750: 738: 734: 733: 718: 656: 655: 651: 641: 639: 627: 622: 621: 617: 601: 596: 595: 586: 579: 565:Streptococcus. 561:"Streptococcus" 558: 557: 553: 509: 508: 501: 486: 481: 480: 469: 464: 439: 403: 391:Emil Gotschlich 348:rheumatic fever 332: 318:Alphonse Dochez 286: 276:found on their 269:composition of 223: 219:Alphonse Dochez 190: 171: 143: 105: 87:Alma mater 71: 62:January 5, 1895 57: 55: 47: 35: 28: 23: 22: 15: 12: 11: 5: 1719: 1717: 1709: 1708: 1703: 1698: 1693: 1688: 1683: 1678: 1673: 1668: 1663: 1658: 1653: 1648: 1643: 1633: 1632: 1626: 1625: 1623: 1622: 1616: 1610: 1604: 1598: 1592: 1589:Susan E. Sharp 1586: 1580: 1574: 1573:(Mar-Dec 2014) 1568: 1567:(Jan-Feb 2014) 1562: 1556: 1550: 1547:Bonnie Bassler 1544: 1541:Roberto Kolter 1538: 1532: 1526: 1520: 1514: 1508: 1502: 1496: 1490: 1483: 1481: 1477: 1476: 1474: 1473: 1467: 1461: 1458:Stanley Falkow 1455: 1449: 1443: 1437: 1431: 1425: 1419: 1413: 1407: 1401: 1395: 1392:Jean Brenchley 1389: 1383: 1377: 1371: 1365: 1359: 1353: 1350:Willis A. Wood 1347: 1341: 1335: 1329: 1322: 1320: 1316: 1315: 1313: 1312: 1306: 1300: 1294: 1288: 1282: 1276: 1270: 1264: 1258: 1252: 1246: 1240: 1234: 1228: 1225:Herald Rea Cox 1222: 1216: 1210: 1204: 1198: 1192: 1186: 1180: 1174: 1168: 1161: 1159: 1155: 1154: 1152: 1151: 1145: 1139: 1133: 1127: 1121: 1115: 1112:Ira L. Baldwin 1109: 1103: 1097: 1091: 1085: 1079: 1073: 1067: 1061: 1055: 1049: 1043: 1037: 1031: 1025: 1022:Ludvig Hektoen 1019: 1013: 1007: 1000: 998: 994: 993: 991: 990: 984: 978: 972: 966: 960: 954: 948: 942: 936: 930: 924: 918: 912: 906: 900: 894: 888: 882: 876: 870: 864: 858: 855:Theobald Smith 852: 846: 840: 833: 831: 827: 826: 821: 819: 818: 811: 804: 796: 788: 787: 763: 759:Science Friday 748: 716: 669:(8): 225–229. 649: 615: 584: 577: 551: 499: 466: 465: 463: 460: 448:Science Friday 438: 435: 402: 399: 387:Maclyn McCarty 331: 328: 290:Fort Wadsworth 285: 282: 241:microbiologist 229: 228: 225: 224: 222: 221: 216: 210: 208: 204: 203: 198: 192: 191: 189: 188: 185: 179: 177: 173: 172: 170: 169: 164: 158: 156: 152: 151: 145: 144: 142: 141: 135: 131: 129: 125: 124: 121: 117: 116: 111: 110:Known for 107: 106: 104: 103: 97: 90: 88: 84: 83: 80: 76: 75: 74:(aged 86) 68: 64: 63: 53: 49: 48: 45: 37: 36: 33: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 1718: 1707: 1704: 1702: 1699: 1697: 1694: 1692: 1689: 1687: 1684: 1682: 1679: 1677: 1674: 1672: 1669: 1667: 1664: 1662: 1659: 1657: 1654: 1652: 1649: 1647: 1644: 1642: 1639: 1638: 1636: 1620: 1619:Colleen Kraft 1617: 1614: 1613:Steven Finkel 1611: 1608: 1607:Victor DiRita 1605: 1602: 1599: 1596: 1593: 1590: 1587: 1584: 1581: 1578: 1575: 1572: 1569: 1566: 1565:Jo Handelsman 1563: 1560: 1557: 1554: 1551: 1548: 1545: 1542: 1539: 1536: 1533: 1530: 1527: 1524: 1521: 1518: 1515: 1512: 1509: 1506: 1503: 1500: 1497: 1494: 1491: 1488: 1485: 1484: 1482: 1478: 1471: 1470:Julian Davies 1468: 1465: 1462: 1459: 1456: 1453: 1450: 1447: 1446:Carol A. 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Retrieved 635: 631: 618: 609: 605: 568: 564: 554: 519: 515: 491: 456: 453: 446: 440: 404: 395:Lasker Prize 383:World War II 380: 376: 352: 344:Hans Zinsser 337: 333: 321: 314:Oswald Avery 287: 267:carbohydrate 249: 233: 232: 214:Oswald Avery 201:Hans Zinsser 176:Institutions 162:Bacteriology 148: 72:(1981-03-03) 1691:Serologists 1646:1981 deaths 1641:1895 births 1601:Robin Patel 1487:Martha Howe 1464:Stuart Levy 1207:Harry Eagle 1118:Stuart Mudd 642:29 November 252:serological 79:Nationality 1635:Categories 1171:René Dubos 781:2018-08-02 612:: 805–810. 462:References 278:cell walls 167:Immunology 58:1895-01-05 1319:1976–2000 1158:1951–1975 997:1926–1950 830:1900–1925 693:0027-8424 516:J Exp Med 356:M-protein 271:bacterial 256:hemolytic 711:16576594 606:ASM News 546:19870148 298:New York 274:antigens 238:American 82:American 702:1084856 671:Bibcode 537:2132252 497:. p.227 381:During 372:group B 368:group A 306:zoology 1621:(2022) 1615:(2021) 1609:(2020) 1603:(2019) 1597:(2018) 1591:(2017) 1585:(2016) 1579:(2015) 1561:(2013) 1555:(2012) 1549:(2011) 1543:(2010) 1537:(2009) 1531:(2008) 1525:(2007) 1519:(2006) 1513:(2005) 1507:(2004) 1501:(2003) 1495:(2002) 1489:(2001) 1472:(2000) 1466:(1999) 1460:(1998) 1454:(1997) 1448:(1996) 1442:(1995) 1436:(1994) 1430:(1993) 1424:(1992) 1418:(1991) 1412:(1990) 1406:(1989) 1400:(1988) 1394:(1987) 1388:(1986) 1382:(1985) 1376:(1984) 1370:(1983) 1364:(1982) 1358:(1981) 1352:(1980) 1346:(1979) 1340:(1978) 1334:(1977) 1328:(1976) 1311:(1975) 1305:(1974) 1299:(1973) 1293:(1972) 1287:(1971) 1281:(1970) 1275:(1969) 1269:(1968) 1263:(1967) 1257:(1966) 1251:(1965) 1245:(1964) 1239:(1963) 1233:(1962) 1227:(1961) 1221:(1960) 1215:(1959) 1209:(1958) 1203:(1957) 1197:(1956) 1191:(1955) 1185:(1954) 1179:(1953) 1173:(1952) 1167:(1951) 1150:(1950) 1144:(1949) 1138:(1948) 1132:(1947) 1126:(1946) 1120:(1945) 1114:(1944) 1108:(1943) 1102:(1942) 1096:(1941) 1090:(1940) 1084:(1939) 1078:(1938) 1072:(1937) 1066:(1936) 1060:(1935) 1054:(1934) 1048:(1933) 1042:(1932) 1036:(1931) 1030:(1930) 1024:(1929) 1018:(1928) 1012:(1927) 1006:(1926) 989:(1925) 983:(1924) 977:(1923) 971:(1922) 965:(1921) 959:(1920) 953:(1919) 947:(1918) 941:(1917) 935:(1916) 929:(1915) 923:(1914) 917:(1913) 911:(1912) 905:(1911) 899:(1910) 893:(1909) 887:(1908) 881:(1907) 875:(1906) 869:(1905) 863:(1904) 857:(1903) 851:(1902) 845:(1901) 839:(1900) 709:  699:  691:  575:  544:  534:  443:eggnog 425:, the 401:Honors 155:Fields 128:Awards 120:Spouse 96:(B.A.) 739:(PDF) 628:(PDF) 602:(PDF) 487:(PDF) 707:PMID 689:ISSN 644:2018 638:(12) 573:ISBN 542:PMID 354:the 316:and 67:Died 52:Born 697:PMC 679:doi 567:in: 532:PMC 524:doi 1637:: 774:. 741:. 719:^ 705:. 695:. 687:. 677:. 665:. 661:. 636:41 634:. 630:. 608:. 604:. 587:^ 540:. 530:. 520:57 518:. 514:. 502:^ 489:. 470:^ 451:. 433:. 397:. 296:, 292:, 261:, 815:e 808:t 801:v 784:. 761:. 745:. 713:. 681:: 673:: 667:7 646:. 610:4 581:. 548:. 526:: 60:) 56:( 20:)

Index

Rebecca Craighill Lancefield

Wellesley College
Columbia University
Lancefield grouping
New York Academy of Medicine
Bacteriology
Immunology
Rockefeller University
Doctoral advisor
Hans Zinsser
Oswald Avery
Alphonse Dochez
American
microbiologist
Rockefeller Institute for Medical Research
serological
hemolytic
streptococcal bacteria
Lancefield grouping
carbohydrate
bacterial
antigens
cell walls
Fort Wadsworth
Staten Island
New York
Wellesley College
zoology
Columbia University

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