228:
2012:
31:
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InChI=1S/C43H50N8O5S/c44-42(56)43(16-20-46-21-17-43)51-41(55)34(22-27-8-2-1-3-9-27)49-39(53)35(23-29-25-47-33-12-6-4-10-31(29)33)50-40(54)36(48-38(52)28-14-18-45-19-15-28)24-30-26-57-37-13-7-5-11-32(30)37/h1-13,25-26,28,34-36,45-47H,14-24H2,(H2,44,56)(H,48,52)(H,49,53)(H,50,54)(H,51,55)/t34-,35+,36+/m0/s1
473:
designation to relamorelin for diabetic gastroparesis. The development of the drug is uncertain as the most recent mention of it was in a 2019 SEC filing from the drug manufacturer lists the drug's expected launch year as 2024, but not in subsequent filings or press releases.
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640:"Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics"
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Haddley K (2014). "Relamorelin. Ghrelin receptor agonist, treatment of constipation, treatment of anorexia nervosa, treatment of diabetic gastroparesis".
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Relamorelin (RM-131): Ghrelin
Peptide Agonist: A New Drug Class for the Treatment of GI Functional Disorders – Rhythm Pharmaceuticals
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599:"Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial"
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689:"Early investigational therapeutics for gastrointestinal motility disorders: from animal studies to Phase II trials"
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547:"Emerging treatments in Neurogastroenterology: relamorelin: a novel gastrocolokinetic synthetic ghrelin agonist"
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Acosta A, Camilleri M, Kolar G, Iturrino J, Szarka LA, Boldingh A, et al. (December 2015).
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Shin A, Camilleri M, Busciglio I, Burton D, Stoner E, Noonan P, et al. (January 2013).
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c1ccc(cc1)C(C(=O)NC2(CCNCC2)C(=O)N)NC(=O)(Cc3cc4c3cccc4)NC(=O)(Cc5csc6c5cccc6)NC(=O)C7CCNCC7
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738:"Rhythm Presents Positive Phase 2 Study Results for Relamorelin for Chronic Constipation"
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93:-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]piperidine-4-carboxamide
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for diabetic gastroparesis and constipation. The United States
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Drugs acting on the gastrointestinal system and metabolism
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778:"AbbVie Reports First-Quarter 2023 Financial Results"
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1372:Placental growth hormone (growth hormone variant)
454:levels, and, like other GHSR agonists, increases
135:
687:Valentin N, Acosta A, Camilleri M (June 2015).
439:. In humans, relamorelin produces increases in
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1467:Tooltip Growth hormone-binding protein
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1038:Magnesium hydroxide (milk of magnesia)
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458:. As of June 2015, relamorelin is in
403:(GHSR) which is under development by
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545:Camilleri M, Acosta A (March 2015).
484:List of growth hormone secretagogues
2137:Systemic hormonal preparation stubs
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2142:Gastrointestinal system drug stubs
2030:. You can help Knowledge (XXG) by
1969:. You can help Knowledge (XXG) by
551:Neurogastroenterology and Motility
14:
2010:
1953:
519:10.1358/dof.2014.039.011.2231856
261:
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29:
736:Rhythm Pharmaceuticals (2014).
413:chronic idiopathic constipation
351:Key:KUBPNVYPKPWGRJ-LIVOIKKVSA-N
2077:Drugs not assigned an ATC code
1412:Somatrogon (MOD-4023; hGH-CTP)
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1:
705:10.1517/13543784.2015.1025132
2117:Growth hormone secretagogues
760:"AbbVie Inc SEC filing 2019"
467:Food and Drug Administration
372:) (developmental code names
1449:Antisense oligonucleotides:
2158:
2005:
1948:
1136:Sodium lauryl sulfoacetate
239:Chemical and physical data
2112:Ghrelin receptor agonists
799:Relamorelin – AdisInsight
616:10.1016/j.cgh.2015.04.184
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77:
28:
2022:article relating to the
1362:Human placental lactogen
834:Drugs for constipation (
405:Allergan pharmaceuticals
2024:gastrointestinal system
1754:Examorelin (hexarelin)
929:Bulk-forming laxatives
409:diabetic gastroparesis
957:Polycarbophil calcium
407:for the treatment of
1963:hormonal preparation
1809:Pralmorelin (GHRP-2)
1352:Eftansomatropin alfa
1131:Sodium laurilsulfate
2122:Motility stimulants
2087:Appetite stimulants
1851:Ibutamoren (MK-677)
1679:Modified GRF (1-29)
1579:Somatostatin (1-28)
1574:Somatostatin (GHIH)
1342:Bovine somatotropin
1068:Polyethylene glycol
1028:Magnesium carbonate
982:Lubricant laxatives
871:Stimulant laxatives
766:. November 7, 2019.
507:Drugs of the Future
393:centrally penetrant
25:
2107:Experimental drugs
1168:Oxycodone/naloxone
1156:Opioid antagonists
1048:Magnesium peroxide
919:Sodium picosulfate
469:(FDA) has granted
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1053:Magnesium sulfate
1033:Magnesium citrate
1005:Osmotic laxatives
656:10.2337/dc12-1128
609:(13): 2312–9.e1.
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208:CompTox Dashboard
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1190:
1187:
1185:
1182:
1180:
1177:
1176:
1175:
1172:
1169:
1165:
1162:
1161:
1159:
1157:
1153:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1108:
1106:
1104:
1100:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1073:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1010:
1008:
1006:
1002:
996:
993:
991:
988:
987:
985:
983:
979:
973:
972:Syrup of figs
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
937:Dietary fiber
935:
934:
932:
930:
926:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
876:
874:
872:
868:
862:
859:
858:
856:
854:
850:
845:
841:
837:
829:
824:
822:
817:
815:
810:
809:
806:
800:
797:
795:
792:
791:
787:
779:
773:
770:
765:
761:
755:
752:
739:
732:
729:
724:
720:
715:
710:
706:
702:
699:(6): 769–79.
698:
694:
690:
683:
680:
675:
671:
666:
661:
657:
653:
649:
645:
644:Diabetes Care
641:
634:
631:
626:
622:
617:
612:
608:
604:
600:
593:
591:
587:
582:
578:
573:
568:
564:
560:
557:(3): 324–32.
556:
552:
548:
541:
539:
537:
533:
528:
524:
520:
516:
512:
508:
501:
499:
495:
489:
485:
482:
481:
477:
475:
472:
468:
464:
461:
457:
453:
449:
445:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
387:
383:
379:
375:
371:
367:
363:
349:
344:
340:
333:
324:
320:
313:
306:
302:
301:
299:
296:
291:
284:
282:
278:
248:
246:
242:
237:
229:
225:
221:
220:
218:
209:
205:
198:
194:
193:
191:
189:
185:
178:
174:
173:
171:
169:
165:
158:
154:
153:
151:
149:
145:
138:
134:
133:
131:
124:
120:
113:
109:
108:
106:
104:
100:
92:
89:4-amino]-3-(1
87:
83:
76:
71:
64:
63:
61:
59:
55:
52:
49:
47:
41:
38:Clinical data
36:
32:
27:
19:
2097:Carboxamides
2032:expanding it
2017:
1971:expanding it
1960:
1885:Antagonists:
1884:
1869:
1841:Capromorelin
1828:Non-peptide:
1827:
1813:
1739:Alexamorelin
1735:
1732:
1706:Antagonists:
1705:
1655:
1652:
1611:Antagonists:
1610:
1604:Veldoreotide
1490:
1458:
1448:
1434:Antagonists:
1433:
1392:Somatotropin
1333:
1242:Prucalopride
1227:Lubiprostone
772:
763:
754:
742:. Retrieved
731:
696:
692:
682:
647:
643:
633:
606:
602:
554:
550:
510:
506:
421:pentapeptide
395:, selective
381:
377:
373:
361:
360:
90:
51:Subcutaneous
18:
2127:Piperidines
1861:Macimorelin
1819:Tabimorelin
1814:Relamorelin
1794:Lenomorelin
1699:Tesamorelin
1694:Somatorelin
1629:Satoreotide
1554:Pasireotide
1539:NNC 26-9100
1519:Ilatreotide
1514:Edotreotide
1452:Atesidorsen
1442:Pegvisomant
1417:Somavaratan
1407:Sometribove
1382:Somapacitan
1377:Somagrebove
1237:Plecanatide
1222:Linaclotide
1199:Naldemedine
995:Mineral oil
740:. PRNewsire
650:(1): 41–8.
513:(11): 775.
362:Relamorelin
288: g·mol
112:661472-41-9
73:Identifiers
23:Relamorelin
2071:Categories
1836:Anamorelin
1824:Ulimorelin
1799:Livoletide
1789:Ipamorelin
1689:Sermorelin
1684:Rismorelin
1624:CYN-154806
1599:Vapreotide
1549:Octreotide
1544:Octreotate
1534:Lanreotide
1509:Depreotide
1427:Somidobove
1422:Somavubove
1387:Somatosalm
1312:modulators
1257:Ulimorelin
1189:Bevenopran
894:Castor oil
840:cathartics
490:References
471:Fast Track
419:. It is a
293:3D model (
281:Molar mass
177:BIW199E18V
148:ChemSpider
103:CAS Number
82:IUPAC name
1878:LY-444711
1873:LY-426410
1870:Unsorted:
1866:SM-130686
1856:L-692,585
1846:CP-464709
1831:Adenosine
1804:LY-444711
1733:Agonists:
1724:(ghrelin)
1669:Dumorelin
1659:ALRN-5281
1653:Agonists:
1614:BIM-23056
1569:Seglitide
1529:L-817,818
1524:L-803,087
1494:BIM-23052
1491:Agonists:
1437:G120K-hGH
1334:Agonists:
1309:signaling
1252:Tenapanor
1247:Tegaserod
1204:Naloxegol
1184:Axelopran
1179:Alvimopan
1111:Bisacodyl
1023:Laminarid
1018:Lactulose
962:Sterculia
947:Ispaghula
884:Bisoxatin
879:Bisacodyl
836:laxatives
527:0377-8282
448:prolactin
386:synthetic
382:BIM-28163
378:BIM-28131
44:Routes of
1939:instead.
1888:A-778193
1749:EP-51216
1736:Peptide:
1709:MZ-5-156
1664:CJC-1295
1656:Peptide:
1402:Somatrem
1164:Naloxone
1146:Sorbitol
1121:Glycerol
1093:Sorbitol
1072:macrogol
1058:Mannitol
1013:Lactitol
967:Triticum
942:Ethulose
861:Docusate
744:June 10,
723:25971881
674:22961573
625:26001337
581:25545036
478:See also
460:phase II
456:appetite
452:cortisol
425:analogue
157:32699203
137:85364156
58:ATC code
1912:YIL-781
1907:JMV2959
1759:Ghrelin
1589:SRIF-28
1584:SRIF-14
1174:PAMORAs
1116:Dantron
899:Dantron
889:Cascara
714:4578705
665:3526234
572:4424792
433:potency
429:ghrelin
423:and an
399:of the
397:agonist
389:peptide
384:) is a
245:Formula
123:PubChem
2082:Amines
1784:GHRP-6
1779:GHRP-5
1774:GHRP-4
1769:GHRP-3
1764:GHRP-1
1594:TT-232
1564:RC-160
1499:CH-275
1215:Others
1103:Enemas
764:AbbVie
721:
711:
672:
662:
623:
579:
569:
525:
450:, and
441:plasma
415:, and
374:RM-131
319:SMILES
286:790.98
197:D10660
2026:is a
2018:This
1961:This
1923:IGF-1
1304:IGF-1
339:InChI
295:JSmol
2028:stub
2020:drug
1967:stub
1937:here
1935:See
1674:GHRH
1640:GHRH
1478:GHIH
1463:GHBP
1306:axis
838:and
746:2015
719:PMID
670:PMID
621:PMID
577:PMID
523:ISSN
435:and
370:USAN
188:KEGG
168:UNII
65:None
1720:GHS
1126:Oil
844:A06
842:) (
709:PMC
701:doi
660:PMC
652:doi
611:doi
567:PMC
559:doi
515:doi
427:of
366:INN
213:EPA
127:CID
2073::
1868:;
1826:;
1321:GH
1300:GH
762:.
717:.
707:.
697:24
695:.
691:.
668:.
658:.
648:36
646:.
642:.
619:.
607:13
605:.
601:.
589:^
575:.
565:.
555:27
553:.
549:.
535:^
521:.
511:39
509:.
497:^
446:,
411:,
391:,
380:,
376:,
368:,
259:50
253:43
2059:e
2052:t
2045:v
2034:.
1998:e
1991:t
1984:v
1973:.
1900:D
1898:(
1302:/
1291:e
1284:t
1277:v
1170:)
1166:(
1074:)
1070:(
846:)
827:e
820:t
813:v
780:.
748:.
725:.
703::
676:.
654::
627:.
613::
583:.
561::
529:.
517::
364:(
297:)
274:S
271:5
268:O
265:8
262:N
256:H
250:C
215:)
211:(
91:H
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