567:(n=245) and 624 cells/μL (n=244) at baseline. Following 52 weeks of reslizumab treatment, eosinophil cells were counted and were reported to be 55 cells/μL (92% reduction, n=212) and 496 cells/μL (21% reduction, n=212) for the reslizumab and placebo treatment groups, respectively. Furthermore, eosinophil count returned towards baseline in those reslizumab-treated patients who completed a follow-up assessment (n=35, 480 cells/μL), approximately 120 days after the last dose of reslizumab. Therefore, reductions of blood eosinophils were related to reslizumab serum levels.
4917:
537:
reslizumab versus placebo. Myalgia was also reported more in patients in the reslizumab 3 mg/kg group versus the placebo group as well as some musculoskeletal adverse reactions. Lastly, some serious adverse reactions that occurred in subjects treated with reslizumab but not in those treated with placebo included anaphylaxis and malignancy.
832:
1059:
1018:
Castro M, Zangrilli J, Wechsler ME, Bateman ED, Brusselle GG, Bardin P, Murphy K, Maspero JF, O'Brien C, Korn S (May 2015). "Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase
458:
Reslizumab is supplied as a refrigerated, sterile, single-use, preservative-free solution for intravenous infusion. The reslizumab solution is a slightly hazy/opalescent, slightly yellow liquid and is supplied as 100 mg in a 10 mL glass vial. Each single-use vial of reslizumab is formulated as
488:
was observed. A large, 981-patient, phase III clinical trial showed that reslizumab was effective at improving lung function, asthma control, and quality of life in comparison to placebo. These results led to the FDA approval for the maintenance treatment of severe asthma in patients aged 18 years
551:
phenotype of asthma that is characterized by the higher than normal presence of eosinophils in the lung and sputum. It has been shown that the numbers of eosinophils in the blood and bronchial fluid can correlate with asthma severity. Reslizumab binds to IL-5 with a dissociation constant of 81
579:
characteristics of reslizumab are similar across the children and adults. Peak serum concentrations are observed at the end of infusion and declines in a biphasic manner. The mean observed accumulation ratio of reslizumab following multiple doses of administration ranged from 1.5 to 1.9-fold.
550:
Reslizumab is an interleukin IL-5 antagonist monoclonal antibody. IL-5 is the major cytokine responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils. Eosinophils play a role in the mediation of inflammation in the airways. Eosinophilic asthma is a
536:
The most common adverse effect of reslizumab was oropharyngeal (mouth and throat) pain. According to the phase III clinical trials data, oropharyngeal pain occurred in ≥2% of individuals along with elevated baseline creatine phosphokinase (CPK), which was more common in patients treated with
421:. By binding to human IL-5, it blocks its biological function; consequently survival and activity of eosinophils are reduced. The benefits with reslizumab are its ability to reduce the exacerbation rate and improve lung function and asthma-related quality of life in patients with severe
444:(FDA) approved reslizumab (Cinqair) for use with other asthma medicines for the maintenance treatment of severe asthma in people aged 18 years and older. It is approved for people who have a history of severe asthma attacks (
563:
Reductions in blood eosinophil counts were observed following the first dose of reslizumab and maintained through 52 weeks of treatment. In phase III clinical trials, mean eosinophil counts were 696 cells/
980:
Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P, et al.. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033–1039.DOI:
776:
195:
3652:
880:
Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, et al. (November 2011). "Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study".
2587:
555:
and inhibiting IL-5 signaling, which reduces the production and survival of eosinophils. However, the mechanism of reslizumab action in asthma has not been definitively established.
150:
377:
718:
608:
and was previously known as SCH-55700. In 1993, Chou and his group at
Schering-Plough were granted the patent for the design, cloning and expression of the reslizumab drug.
484:
eosinophils. Furthermore, the patients receiving reslizumab showed improvements in airway function, and a general trend toward greater asthma control than those receiving
1098:
1057:, "Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5", published 19 August 1993, assigned to Schering Corporation
849:
425:(with blood eosinophil count ≥ 400 cells/μL) and with at least one previous asthma exacerbation in the preceding year. The most common side effects are increased blood
666:
4937:
3645:
88:
790:
1145:
949:
459:
10 mg/mL reslizumab in an aqueous solution containing 2.45 mg/mL sodium acetate trihydrate, 0.12 mg/mL glacial acetic acid, and 70 mg/mL
2580:
692:
455:
recommended the granting of a marketing authorisation for reslizumab (Cinqaero) intended as add-on treatment in adults with severe eosinophilic asthma.
34:
3638:
2061:
4850:
4117:
2573:
4854:
4840:
4800:
3596:
4869:
4774:
3722:
2004:
1374:
584:
of approximately 5 L, clearance of approximately 7 mL/hour, and a half-life of about 24 days. Reslizumab is degraded by enzymatic
1138:
746:
Walsh GM (June 2009). "Reslizumab, a humanized anti-IL-5 mAb for the treatment of eosinophil-mediated inflammatory conditions".
2413:
1106:
817:
180:
106:
3568:
4735:
4714:
406:
4907:
4942:
3578:
1210:
1073:
927:
858:
823:
441:
335:
612:
acquired the drug and continued its development under the name CTx55700. In 2010, Ception
Therapeutics was acquired by
3613:
1319:
1131:
125:
1189:
3162:
1867:
957:
784:
452:
918:
2247:
4693:
4653:
4632:
4576:
4544:
4503:
4461:
4415:
4334:
4308:
4252:
4211:
4185:
4159:
3813:
3601:
2242:
136:
4268:
4128:
4108:
4087:
4006:
3945:
3889:
3843:
3767:
3672:
2047:
1473:
1154:
609:
581:
434:
426:
991:
638:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2674:
2596:
2234:
3778:
4890:
4673:
3661:
2878:
1123:
637:
617:
261:
3803:
4664:
4222:
4017:
3793:
3687:
1455:
422:
279:
44:
27:
4534:
4529:
616:
for $ 250 million and the drug continued under development under the codename CEP-38072. In 2011,
4514:
4426:
4405:
3854:
3788:
3747:
3691:
3664:
3063:
3022:
2862:
2654:
2404:
1505:
4395:
4263:
4170:
4149:
3900:
3869:
3864:
3808:
3727:
2444:
2302:
4441:
3874:
3702:
3697:
2454:
2140:
1581:
4047:
4032:
3996:
3966:
3712:
2954:
2624:
2565:
2409:
2399:
1200:
1158:
1036:
897:
755:
207:
78:
4885:
2944:
2934:
2205:
2108:
1771:
1667:
1028:
889:
576:
288:
241:
4361:
4357:
4353:
344:
4921:
4677:
3362:
3138:
2504:
2389:
950:"CENTER FOR DRUG EVALUATION AND RESEARCH : APPLICATION NUMBER : 761033Orig1s000"
919:"CENTER FOR DRUG EVALUATION AND RESEARCH : APPLICATION NUMBER : 761033Orig1s000"
605:
249:
4875:
4865:
4860:
4846:
4832:
4822:
4817:
4764:
4746:
4725:
4704:
4683:
4669:
4643:
4587:
4555:
4519:
4482:
4477:
4472:
4436:
4431:
4345:
4324:
4278:
4227:
4196:
4175:
3910:
3879:
3607:
2394:
2262:
1910:
1744:
1723:
1719:
1715:
1343:
1180:
477:
1032:
476:
Reslizumab was first used for eosinophilic asthma in 2008. In a 106-patient, phase II
4931:
4617:
4273:
4139:
4098:
4022:
3956:
3905:
3859:
3798:
3683:
3517:
3318:
3263:
3188:
3148:
3068:
2962:
2608:
2600:
2544:
2474:
2384:
2291:
2077:
1777:
1699:
1651:
1631:
1489:
1405:
1256:
1222:
836:
723:
501:
417:
responsible for the differentiation, maturation, recruitment and activation of human
410:
219:
66:
4791:
4612:
4298:
4293:
4288:
4037:
3976:
3935:
3507:
3492:
3472:
3462:
3441:
3357:
3298:
3283:
3253:
3233:
3228:
3203:
3183:
3178:
3173:
3123:
3113:
3103:
3053:
3048:
3043:
2972:
2857:
2841:
2744:
2734:
2729:
2704:
2644:
2554:
2514:
2499:
2494:
2210:
2160:
2155:
2135:
2015:
2010:
1873:
1858:
1806:
1782:
1729:
1606:
1596:
1415:
1332:
1327:
1285:
1238:
1195:
1162:
445:
163:
158:
3630:
667:"Prescription medicines: registration of new chemical entities in Australia, 2017"
98:
620:
acquired
Cephalon for $ 6.8 billion and continued the development of reslizumab.
4622:
4602:
4565:
4400:
4390:
4242:
4237:
4072:
4042:
3981:
3823:
3783:
3742:
3737:
3573:
3563:
3502:
3487:
3477:
3467:
3446:
3431:
3416:
3411:
3406:
3381:
3334:
3313:
3308:
3303:
3293:
3288:
3273:
3248:
3238:
3218:
3198:
3193:
3158:
3153:
3143:
3133:
3128:
3098:
3088:
3058:
3012:
3007:
2997:
2982:
2967:
2939:
2924:
2909:
2904:
2899:
2867:
2810:
2805:
2795:
2775:
2754:
2749:
2719:
2639:
2549:
2489:
2479:
2469:
2369:
2359:
2349:
2344:
2309:
2220:
2215:
2190:
2180:
2170:
2145:
2130:
2125:
2083:
2053:
2039:
2034:
2020:
1963:
1921:
1916:
1902:
1897:
1883:
1863:
1816:
1792:
1750:
1734:
1705:
1689:
1657:
1641:
1636:
1611:
1561:
1551:
1546:
1541:
1530:
1520:
1425:
1337:
1295:
1280:
1274:
1270:
1217:
1054:
585:
254:
143:
893:
4607:
4597:
4492:
4385:
4380:
4201:
4062:
4052:
3920:
3833:
3828:
3757:
3533:
3512:
3497:
3482:
3426:
3421:
3401:
3396:
3367:
3341:
3278:
3258:
3243:
3213:
3168:
3118:
3108:
3083:
3078:
3073:
3038:
3033:
3002:
2987:
2929:
2919:
2914:
2894:
2831:
2826:
2815:
2785:
2780:
2724:
2699:
2684:
2669:
2664:
2634:
2539:
2534:
2519:
2459:
2449:
2434:
2429:
2424:
2374:
2364:
2354:
2319:
2297:
2283:
2195:
2175:
2165:
2150:
2093:
2088:
2067:
1982:
1977:
1935:
1929:
1830:
1787:
1683:
1673:
1626:
1616:
1591:
1586:
1576:
1571:
1566:
1556:
1515:
1500:
1495:
1479:
1420:
1400:
1349:
1309:
1290:
1232:
593:
564:
530:
418:
319:
4077:
4067:
4057:
3930:
3436:
3268:
3093:
2992:
2977:
2836:
2800:
2790:
2764:
2759:
2739:
2714:
2709:
2694:
2689:
2659:
2629:
2529:
2524:
2509:
2484:
2439:
2419:
2379:
2314:
2278:
2200:
1996:
1949:
1878:
1844:
1811:
1621:
1601:
1510:
1410:
1250:
552:
92:
49:
1040:
901:
759:
20:
3717:
2846:
2769:
2679:
2649:
2464:
2339:
2028:
1536:
1446:
1382:
1304:
613:
414:
299:
120:
308:
4836:
4319:
3323:
3208:
1957:
589:
485:
460:
430:
61:
4451:
3548:
2272:
2103:
481:
364:
4758:
4754:
4750:
4369:
4365:
4349:
1971:
1824:
835:
This article incorporates text from this source, which is in the
693:"Prescription medicines and biologicals: TGA annual summary 2017"
1943:
1891:
1852:
1838:
1392:
1266:
355:
228:
3634:
2569:
1127:
213:
115:
4826:
1800:
645:
480:, the researchers showed reslizumab was effective in reducing
53:
489:
and older, with an eosinophilic phenotype on March 23, 2016.
850:"PULMONARY-ALLERGY DRUGS ADVISORY COMMITTEE (PADAC) MEETING"
189:
882:
American
Journal of Respiratory and Critical Care Medicine
719:"Health Canada New Drug Authorizations: 2016 Highlights"
604:
Reslizumab was initially developed by Chuan-Chu Chou at
202:
1099:"Teva to Acquire Cephalon in $ 6.8 Billion Transaction"
384:
992:"HIGHLIGHTS OF PRESCRIBING INFORMATION : CINQAIR"
4905:
413:(IL-5). Reslizumab binds specifically to IL-5, a key
1074:"Cephalon pays $ 250M to snare Ception Therapeutics"
448:) despite receiving their current asthma medicines.
4810:
4790:
4783:
4734:
4713:
4692:
4652:
4631:
4575:
4543:
4502:
4460:
4414:
4333:
4307:
4251:
4210:
4184:
4158:
4127:
4107:
4086:
4005:
3944:
3888:
3842:
3766:
3671:
3556:
3546:
3526:
3455:
3389:
3380:
3349:
3021:
2953:
2887:
2616:
2607:
2332:
2260:
2233:
2118:
1761:
1463:
1454:
1445:
1438:
1391:
1373:
1364:
1318:
1249:
1179:
1170:
354:
334:
318:
298:
278:
273:
260:
248:
240:
179:
174:
149:
135:
105:
87:
77:
72:
60:
43:
33:
26:
812:
810:
287:
3646:
2581:
1139:
818:"FDA approves Cinqair to treat severe asthma"
8:
124:
19:
771:
769:
4787:
3653:
3639:
3631:
3553:
3386:
2613:
2588:
2574:
2566:
1460:
1451:
1442:
1370:
1176:
1146:
1132:
1124:
913:
911:
748:Current Opinion in Molecular Therapeutics
343:
4818:Interleukin 14 (taxilin alpha, HMW-BCGF)
4912:
629:
307:
4938:Anti-interleukin monoclonal antibodies
4116:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
697:Therapeutic Goods Administration (TGA)
671:Therapeutic Goods Administration (TGA)
596:, as are other monoclonal antibodies.
18:
508:Less common adverse effects include:
97:
7:
162:
363:
14:
4915:
1021:The Lancet. Respiratory Medicine
830:
497:Common adverse effects include:
4644:Interleukin 27 (interleukin 30)
828:(Press release). 23 March 2016.
1:
1033:10.1016/S2213-2600(15)00042-9
407:humanized monoclonal antibody
397:, sold under the brand names
1211:dihydroorotate dehydrogenase
928:Food and Drug Administration
859:Food and Drug Administration
824:Food and Drug Administration
777:"Cinqaero : reslizumab"
442:Food and Drug Administration
3994:Antisense oligonucleotides:
1190:purine synthesis inhibitors
981:10.1056/NEJM199010113231505
4959:
894:10.1164/rccm.201103-0396OC
3591:
1375:IL-1 receptor antagonists
785:European Medicines Agency
453:European Medicines Agency
374:
2248:Anti-lymphocyte globulin
4684:Interleukin-29 (IFN-λ1)
3829:Daclizumab (dacliximab)
3814:Tucotuzumab celmoleukin
2243:Anti-thymocyte globulin
1155:Immunosuppressive drugs
4665:Interferon λ4 (IFN-λ4)
3758:Rilonacept (IL-1 Trap)
2048:Interleukin-6 receptor
1474:Complement component 5
582:volume of distribution
440:In March 2016, the US
435:anaphylactic reactions
427:creatine phosphokinase
4588:Interleukin 23 (SGRF)
4269:Cintredekin besudotox
4197:Interleukin 11 (AGIF)
4176:Interleukin 10 (CSIF)
2675:Camidanlumab tesirine
2597:Monoclonal antibodies
3662:Interleukin receptor
3350:Chimeric + humanized
2879:Nivolumab/relatlimab
618:Teva Pharmaceuticals
610:Ception Therapeutics
512:musculoskeletal pain
463:, with a pH of 5.5.
4943:Antiasthmatic drugs
3794:Denileukin diftitox
546:Mechanism of action
472:Eosinophilic asthma
423:eosinophilic asthma
198:(Prescription only)
28:Monoclonal antibody
23:
16:Pharmaceutical drug
4366:E (interleukin 25)
3618:Never to phase III
3064:Certolizumab pegol
3031:Immunosuppressive:
2405:Diroximel fumarate
2078:IL-2 receptor/CD25
1506:Certolizumab pegol
1159:Immunosuppressants
999:Accessdata.fda.gov
954:Accessdata.fda.gov
451:In June 2016, the
4903:
4902:
4899:
4898:
4868:(signals through
4849:(signals through
4835:(signals through
4825:(signals through
4449:Binding proteins:
3779:Adargileukin alfa
3628:
3627:
3587:
3586:
3542:
3541:
3376:
3375:
3331:Immune activation
2823:Immune activation
2625:Immunosuppression
2563:
2562:
2410:Efgartigimod alfa
2400:Dimethyl fumarate
2328:
2327:
2256:
2255:
2229:
2228:
1434:
1433:
1360:
1359:
1201:Mycophenolic acid
1078:FierceBiotech.com
580:Reslizumab has a
392:
391:
232:
217:
205:
193:
118:
83:Cinqair, Cinqaero
4950:
4920:
4919:
4918:
4911:
4891:Efineptakin alfa
4886:Efavaleukin alfa
4788:
3755:Decoy receptors:
3655:
3648:
3641:
3632:
3554:
3387:
2945:Zolimomab aritox
2935:Telimomab aritox
2614:
2590:
2583:
2576:
2567:
2206:Telimomab aritox
2109:Zolimomab aritox
1930:CD62L/L-selectin
1668:Immunoglobulin E
1461:
1452:
1443:
1371:
1177:
1148:
1141:
1134:
1125:
1118:
1117:
1115:
1114:
1105:. Archived from
1095:
1089:
1088:
1086:
1085:
1070:
1064:
1063:
1062:
1058:
1051:
1045:
1044:
1015:
1009:
1008:
1006:
1005:
996:
988:
982:
978:
972:
971:
969:
968:
962:
956:. Archived from
946:
940:
939:
937:
936:
923:
915:
906:
905:
877:
871:
870:
868:
867:
854:
846:
840:
834:
833:
829:
814:
805:
804:
802:
801:
795:
789:. Archived from
781:
773:
764:
763:
743:
737:
736:
734:
732:
715:
709:
708:
706:
704:
689:
683:
682:
680:
678:
663:
657:
656:
654:
652:
642:nctr-crs.fda.gov
634:
571:Pharmacokinetics
559:Pharmacodynamics
388:
387:
380:
367:
347:
311:
291:
265:
230:
227:
222:
215:
212:
204:
201:
191:
188:
166:
128:
117:
114:
101:
24:
22:
4958:
4957:
4953:
4952:
4951:
4949:
4948:
4947:
4928:
4927:
4926:
4916:
4914:
4906:
4904:
4895:
4806:
4779:
4730:
4709:
4688:
4648:
4627:
4571:
4568:(against IL-22)
4539:
4498:
4495:(against IL-20)
4456:
4410:
4329:
4303:
4247:
4206:
4180:
4154:
4123:
4103:
4082:
4001:
3940:
3884:
3838:
3762:
3667:
3659:
3629:
3624:
3623:
3608:Clinical trials
3583:
3538:
3522:
3451:
3372:
3363:Rozanolixizumab
3351:
3345:
3337:
3326:
3139:Lulizumab pegol
3017:
2949:
2883:
2603:
2594:
2564:
2559:
2505:Rozanolixizumab
2390:Deucravacitinib
2324:
2252:
2225:
2114:
1763:
1757:
1465:
1430:
1387:
1366:
1356:
1314:
1254:
1245:
1181:Antimetabolites
1172:
1166:
1152:
1122:
1121:
1112:
1110:
1097:
1096:
1092:
1083:
1081:
1072:
1071:
1067:
1060:
1053:
1052:
1048:
1017:
1016:
1012:
1003:
1001:
994:
990:
989:
985:
979:
975:
966:
964:
960:
948:
947:
943:
934:
932:
921:
917:
916:
909:
888:(10): 1125–32.
879:
878:
874:
865:
863:
852:
848:
847:
843:
831:
816:
815:
808:
799:
797:
793:
779:
775:
774:
767:
745:
744:
740:
730:
728:
727:. 14 March 2017
717:
716:
712:
702:
700:
691:
690:
686:
676:
674:
665:
664:
660:
650:
648:
636:
635:
631:
626:
606:Schering-Plough
602:
577:pharmacokinetic
573:
561:
548:
543:
495:
493:Adverse effects
474:
469:
383:
381:
378:(what is this?)
375:
370:
350:
330:
314:
294:
263:
242:Pharmacokinetic
236:
220:
170:
138:
131:
17:
12:
11:
5:
4956:
4954:
4946:
4945:
4940:
4930:
4929:
4925:
4924:
4901:
4900:
4897:
4896:
4894:
4893:
4888:
4879:
4878:
4876:Interleukin 35
4873:
4866:Interleukin 34
4863:
4861:Interleukin 32
4858:
4847:Interleukin 26
4844:
4833:Interleukin 24
4830:
4823:Interleukin 16
4820:
4814:
4812:
4808:
4807:
4805:
4804:
4796:
4794:
4785:
4781:
4780:
4778:
4777:
4768:
4767:
4765:Interleukin 38
4762:
4747:Interleukin 36
4740:
4738:
4732:
4731:
4729:
4728:
4726:Interleukin 33
4719:
4717:
4711:
4710:
4708:
4707:
4705:Interleukin 31
4698:
4696:
4690:
4689:
4687:
4686:
4681:
4670:Interleukin 28
4667:
4658:
4656:
4650:
4649:
4647:
4646:
4637:
4635:
4629:
4628:
4626:
4625:
4620:
4615:
4610:
4605:
4600:
4591:
4590:
4581:
4579:
4573:
4572:
4570:
4569:
4559:
4558:
4556:Interleukin 22
4549:
4547:
4541:
4540:
4538:
4537:
4532:
4523:
4522:
4520:Interleukin 21
4517:
4508:
4506:
4500:
4499:
4497:
4496:
4486:
4485:
4483:Interleukin 24
4480:
4478:Interleukin 20
4475:
4473:Interleukin 19
4466:
4464:
4458:
4457:
4455:
4454:
4445:
4444:
4439:
4437:Interleukin 37
4434:
4432:Interleukin 18
4429:
4420:
4418:
4412:
4411:
4409:
4408:
4403:
4398:
4393:
4388:
4383:
4374:
4373:
4346:Interleukin 17
4339:
4337:
4331:
4330:
4328:
4327:
4325:Interleukin 15
4322:
4313:
4311:
4305:
4304:
4302:
4301:
4296:
4291:
4282:
4281:
4279:Interleukin 13
4276:
4271:
4266:
4257:
4255:
4249:
4248:
4246:
4245:
4240:
4231:
4230:
4228:Interleukin 12
4225:
4216:
4214:
4208:
4207:
4205:
4204:
4199:
4190:
4188:
4182:
4181:
4179:
4178:
4173:
4164:
4162:
4156:
4155:
4153:
4152:
4143:
4142:
4133:
4131:
4125:
4124:
4122:
4121:
4113:
4111:
4105:
4104:
4102:
4101:
4092:
4090:
4084:
4083:
4081:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4026:
4025:
4020:
4011:
4009:
4003:
4002:
4000:
3999:
3990:
3989:
3984:
3979:
3970:
3969:
3960:
3959:
3950:
3948:
3942:
3941:
3939:
3938:
3933:
3924:
3923:
3914:
3913:
3911:Interleukin 13
3908:
3903:
3894:
3892:
3886:
3885:
3883:
3882:
3880:Promegapoietin
3877:
3872:
3867:
3862:
3857:
3848:
3846:
3840:
3839:
3837:
3836:
3831:
3826:
3817:
3816:
3811:
3806:
3804:Pegaldesleukin
3801:
3796:
3791:
3786:
3781:
3772:
3770:
3764:
3763:
3761:
3760:
3751:
3750:
3745:
3740:
3731:
3730:
3725:
3720:
3715:
3706:
3705:
3700:
3695:
3677:
3675:
3669:
3668:
3660:
3658:
3657:
3650:
3643:
3635:
3626:
3625:
3622:
3621:
3620:
3619:
3616:
3605:
3599:
3593:
3592:
3589:
3588:
3585:
3584:
3582:
3581:
3576:
3571:
3566:
3560:
3558:
3551:
3544:
3543:
3540:
3539:
3537:
3536:
3530:
3528:
3524:
3523:
3521:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3459:
3457:
3453:
3452:
3450:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3393:
3391:
3384:
3378:
3377:
3374:
3373:
3371:
3370:
3365:
3360:
3354:
3352:
3347:
3346:
3328:
3327:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3163:+hyaluronidase
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3027:
3025:
3019:
3018:
3016:
3015:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2959:
2957:
2951:
2950:
2948:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2902:
2897:
2891:
2889:
2885:
2884:
2882:
2881:
2871:
2870:
2865:
2860:
2850:
2849:
2844:
2839:
2834:
2829:
2819:
2818:
2813:
2808:
2803:
2798:
2793:
2788:
2783:
2778:
2773:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2702:
2697:
2692:
2687:
2682:
2677:
2672:
2667:
2662:
2657:
2652:
2647:
2642:
2637:
2632:
2620:
2618:
2611:
2605:
2604:
2595:
2593:
2592:
2585:
2578:
2570:
2561:
2560:
2558:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2452:
2447:
2442:
2437:
2432:
2427:
2422:
2417:
2414:+hyaluronidase
2407:
2402:
2397:
2395:Deuruxolitinib
2392:
2387:
2382:
2377:
2372:
2367:
2362:
2357:
2352:
2347:
2342:
2336:
2334:
2330:
2329:
2326:
2325:
2323:
2322:
2317:
2312:
2307:
2306:
2305:
2300:
2288:
2287:
2286:
2281:
2268:
2266:
2258:
2257:
2254:
2253:
2251:
2250:
2245:
2239:
2237:
2231:
2230:
2227:
2226:
2224:
2223:
2218:
2213:
2208:
2203:
2198:
2193:
2188:
2183:
2178:
2173:
2168:
2163:
2158:
2153:
2148:
2143:
2138:
2133:
2128:
2122:
2120:
2116:
2115:
2113:
2112:
2099:
2098:
2097:
2096:
2091:
2086:
2073:
2072:
2071:
2070:
2058:
2057:
2056:
2044:
2043:
2042:
2037:
2025:
2024:
2023:
2018:
2013:
2001:
2000:
1999:
1988:
1987:
1986:
1985:
1980:
1968:
1967:
1966:
1954:
1953:
1952:
1940:
1939:
1938:
1926:
1925:
1924:
1919:
1907:
1906:
1905:
1900:
1888:
1887:
1886:
1881:
1876:
1871:
1868:+hyaluronidase
1861:
1849:
1848:
1847:
1835:
1834:
1833:
1821:
1820:
1819:
1814:
1809:
1797:
1796:
1795:
1790:
1785:
1780:
1767:
1765:
1759:
1758:
1756:
1755:
1754:
1753:
1740:
1739:
1738:
1737:
1732:
1711:
1710:
1709:
1708:
1695:
1694:
1693:
1692:
1679:
1678:
1677:
1676:
1663:
1662:
1661:
1660:
1647:
1646:
1645:
1644:
1639:
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1526:
1525:
1524:
1523:
1518:
1513:
1508:
1503:
1498:
1485:
1484:
1483:
1482:
1469:
1467:
1458:
1449:
1440:
1436:
1435:
1432:
1431:
1429:
1428:
1423:
1418:
1413:
1408:
1403:
1397:
1395:
1389:
1388:
1386:
1385:
1379:
1377:
1368:
1362:
1361:
1358:
1357:
1355:
1354:
1353:
1352:
1344:PDE4 inhibitor
1340:
1335:
1330:
1324:
1322:
1316:
1315:
1313:
1312:
1307:
1301:
1300:
1299:
1298:
1293:
1288:
1283:
1262:
1260:
1247:
1246:
1244:
1243:
1242:
1241:
1228:
1227:
1226:
1225:
1220:
1206:
1205:
1204:
1203:
1198:
1185:
1183:
1174:
1168:
1167:
1153:
1151:
1150:
1143:
1136:
1128:
1120:
1119:
1090:
1065:
1046:
1010:
983:
973:
941:
907:
872:
841:
806:
765:
738:
710:
699:. 21 June 2022
684:
673:. 21 June 2022
658:
628:
627:
625:
622:
601:
598:
572:
569:
560:
557:
547:
544:
542:
539:
534:
533:
528:
525:
524:muscle fatigue
522:
521:extremity pain
519:
516:
513:
506:
505:
494:
491:
478:clinical trial
473:
470:
468:
465:
409:against human
390:
389:
372:
371:
369:
368:
360:
358:
352:
351:
349:
348:
340:
338:
332:
331:
329:
328:
324:
322:
316:
315:
313:
312:
304:
302:
296:
295:
293:
292:
284:
282:
276:
275:
271:
270:
267:
258:
257:
252:
246:
245:
238:
237:
235:
234:
225:
210:
199:
185:
183:
177:
176:
172:
171:
169:
168:
155:
153:
147:
146:
141:
139:administration
133:
132:
130:
129:
111:
109:
103:
102:
95:
85:
84:
81:
75:
74:
70:
69:
64:
58:
57:
47:
41:
40:
39:Whole antibody
37:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
4955:
4944:
4941:
4939:
4936:
4935:
4933:
4923:
4913:
4909:
4892:
4889:
4887:
4884:
4881:
4880:
4877:
4874:
4871:
4867:
4864:
4862:
4859:
4856:
4852:
4848:
4845:
4842:
4838:
4834:
4831:
4828:
4824:
4821:
4819:
4816:
4815:
4813:
4809:
4802:
4798:
4797:
4795:
4793:
4789:
4786:
4782:
4776:
4773:
4770:
4769:
4766:
4763:
4760:
4756:
4752:
4748:
4745:
4742:
4741:
4739:
4737:
4733:
4727:
4724:
4721:
4720:
4718:
4716:
4712:
4706:
4703:
4700:
4699:
4697:
4695:
4691:
4685:
4682:
4679:
4675:
4671:
4668:
4666:
4663:
4660:
4659:
4657:
4655:
4651:
4645:
4642:
4639:
4638:
4636:
4634:
4630:
4624:
4621:
4619:
4618:Tildrakizumab
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4593:
4592:
4589:
4586:
4583:
4582:
4580:
4578:
4574:
4567:
4564:
4561:
4560:
4557:
4554:
4551:
4550:
4548:
4546:
4542:
4536:
4533:
4531:
4528:
4525:
4524:
4521:
4518:
4516:
4513:
4510:
4509:
4507:
4505:
4501:
4494:
4491:
4488:
4487:
4484:
4481:
4479:
4476:
4474:
4471:
4468:
4467:
4465:
4463:
4459:
4453:
4450:
4447:
4446:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4422:
4421:
4419:
4417:
4413:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4376:
4375:
4371:
4367:
4363:
4359:
4355:
4351:
4347:
4344:
4341:
4340:
4338:
4336:
4332:
4326:
4323:
4321:
4318:
4315:
4314:
4312:
4310:
4306:
4300:
4297:
4295:
4292:
4290:
4287:
4284:
4283:
4280:
4277:
4275:
4274:Interleukin 4
4272:
4270:
4267:
4265:
4262:
4259:
4258:
4256:
4254:
4250:
4244:
4241:
4239:
4236:
4233:
4232:
4229:
4226:
4224:
4223:Edodekin alfa
4221:
4218:
4217:
4215:
4213:
4209:
4203:
4200:
4198:
4195:
4192:
4191:
4189:
4187:
4183:
4177:
4174:
4172:
4169:
4166:
4165:
4163:
4161:
4157:
4151:
4148:
4145:
4144:
4141:
4140:Interleukin 9
4138:
4135:
4134:
4132:
4130:
4126:
4119:
4115:
4114:
4112:
4110:
4106:
4100:
4099:Interleukin 7
4097:
4094:
4093:
4091:
4089:
4085:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4028:
4027:
4024:
4023:Interleukin 6
4021:
4019:
4018:Atexakin alfa
4016:
4013:
4012:
4010:
4008:
4004:
3998:
3995:
3992:
3991:
3988:
3985:
3983:
3980:
3978:
3975:
3972:
3971:
3968:
3965:
3962:
3961:
3958:
3957:Interleukin 5
3955:
3952:
3951:
3949:
3947:
3943:
3937:
3934:
3932:
3929:
3926:
3925:
3922:
3919:
3916:
3915:
3912:
3909:
3907:
3906:Interleukin 4
3904:
3902:
3899:
3896:
3895:
3893:
3891:
3887:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3860:Interleukin 3
3858:
3856:
3853:
3850:
3849:
3847:
3845:
3841:
3835:
3832:
3830:
3827:
3825:
3822:
3819:
3818:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3799:Interleukin 2
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3774:
3773:
3771:
3769:
3765:
3759:
3756:
3753:
3752:
3749:
3746:
3744:
3741:
3739:
3736:
3733:
3732:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3708:
3707:
3704:
3701:
3699:
3696:
3693:
3689:
3685:
3684:Interleukin 1
3682:
3679:
3678:
3676:
3674:
3670:
3666:
3663:
3656:
3651:
3649:
3644:
3642:
3637:
3636:
3633:
3617:
3615:
3612:
3611:
3609:
3606:
3603:
3600:
3598:
3595:
3594:
3590:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3561:
3559:
3555:
3552:
3550:
3547:Inflammatory
3545:
3535:
3532:
3531:
3529:
3525:
3519:
3518:Tildrakizumab
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3460:
3458:
3454:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3394:
3392:
3388:
3385:
3383:
3379:
3369:
3366:
3364:
3361:
3359:
3356:
3355:
3353:
3348:
3344:
3343:
3340:
3336:
3332:
3325:
3322:
3320:
3319:Vobarilizumab
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3264:Spartalizumab
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3189:Pembrolizumab
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3164:
3160:
3157:
3155:
3152:
3150:
3149:Mogamulizumab
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3069:Crizanlizumab
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3029:
3028:
3026:
3024:
3020:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2963:Andecaliximab
2961:
2960:
2958:
2956:
2952:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2892:
2890:
2886:
2880:
2876:
2873:
2872:
2869:
2866:
2864:
2861:
2859:
2855:
2852:
2851:
2848:
2845:
2843:
2840:
2838:
2835:
2833:
2830:
2828:
2824:
2821:
2820:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2681:
2678:
2676:
2673:
2671:
2668:
2666:
2663:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2627:
2626:
2622:
2621:
2619:
2615:
2612:
2610:
2609:Immune system
2606:
2602:
2601:immune system
2598:
2591:
2586:
2584:
2579:
2577:
2572:
2571:
2568:
2556:
2553:
2551:
2548:
2546:
2545:Tildrakizumab
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2481:
2478:
2476:
2475:Pegcetacoplan
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2415:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2385:Darvadstrocel
2383:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2337:
2335:
2331:
2321:
2318:
2316:
2313:
2311:
2308:
2304:
2301:
2299:
2296:
2295:
2294:
2293:
2292:TNF inhibitor
2289:
2285:
2282:
2280:
2277:
2276:
2275:
2274:
2270:
2269:
2267:
2264:
2259:
2249:
2246:
2244:
2241:
2240:
2238:
2236:
2232:
2222:
2219:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2177:
2174:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
2154:
2152:
2149:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2129:
2127:
2124:
2123:
2121:
2117:
2110:
2106:
2105:
2101:
2100:
2095:
2092:
2090:
2087:
2085:
2082:
2081:
2080:
2079:
2075:
2074:
2069:
2066:
2065:
2064:
2063:
2059:
2055:
2052:
2051:
2050:
2049:
2045:
2041:
2038:
2036:
2033:
2032:
2031:
2030:
2026:
2022:
2019:
2017:
2014:
2012:
2009:
2008:
2007:
2006:
2002:
1998:
1995:
1994:
1993:
1990:
1989:
1984:
1981:
1979:
1976:
1975:
1974:
1973:
1969:
1965:
1962:
1961:
1960:
1959:
1958:CD147/Basigin
1955:
1951:
1948:
1947:
1946:
1945:
1941:
1937:
1934:
1933:
1932:
1931:
1927:
1923:
1920:
1918:
1915:
1914:
1913:
1912:
1908:
1904:
1901:
1899:
1896:
1895:
1894:
1893:
1889:
1885:
1882:
1880:
1877:
1875:
1872:
1869:
1865:
1862:
1860:
1857:
1856:
1855:
1854:
1850:
1846:
1843:
1842:
1841:
1840:
1836:
1832:
1829:
1828:
1827:
1826:
1822:
1818:
1815:
1813:
1810:
1808:
1805:
1804:
1803:
1802:
1798:
1794:
1791:
1789:
1786:
1784:
1781:
1779:
1778:Muromonab-CD3
1776:
1775:
1774:
1773:
1769:
1768:
1766:
1760:
1752:
1749:
1748:
1747:
1746:
1742:
1741:
1736:
1733:
1731:
1728:
1727:
1726:
1725:
1721:
1717:
1713:
1712:
1707:
1704:
1703:
1702:
1701:
1697:
1696:
1691:
1688:
1687:
1686:
1685:
1681:
1680:
1675:
1672:
1671:
1670:
1669:
1665:
1664:
1659:
1656:
1655:
1654:
1653:
1652:Interleukin 5
1649:
1648:
1643:
1640:
1638:
1635:
1633:
1632:Tildrakizumab
1630:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1573:
1570:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1534:
1533:
1532:
1528:
1527:
1522:
1519:
1517:
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1493:
1492:
1491:
1487:
1486:
1481:
1478:
1477:
1476:
1475:
1471:
1470:
1468:
1466:(noncellular)
1462:
1459:
1457:
1453:
1450:
1448:
1444:
1441:
1439:Extracellular
1437:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1406:Ridaforolimus
1404:
1402:
1399:
1398:
1396:
1394:
1390:
1384:
1381:
1380:
1378:
1376:
1372:
1369:
1365:Intracellular
1363:
1351:
1348:
1347:
1346:
1345:
1341:
1339:
1336:
1334:
1331:
1329:
1326:
1325:
1323:
1321:
1317:
1311:
1308:
1306:
1303:
1302:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1278:
1277:
1276:
1272:
1268:
1264:
1263:
1261:
1258:
1252:
1248:
1240:
1237:
1236:
1235:
1234:
1230:
1229:
1224:
1223:Teriflunomide
1221:
1219:
1216:
1215:
1213:
1212:
1208:
1207:
1202:
1199:
1197:
1194:
1193:
1192:
1191:
1187:
1186:
1184:
1182:
1178:
1175:
1171:Intracellular
1169:
1164:
1160:
1156:
1149:
1144:
1142:
1137:
1135:
1130:
1129:
1126:
1109:on 2016-11-21
1108:
1104:
1103:Tevapharm.com
1100:
1094:
1091:
1079:
1075:
1069:
1066:
1056:
1055:WO 1993016184
1050:
1047:
1042:
1038:
1034:
1030:
1027:(5): 355–66.
1026:
1022:
1014:
1011:
1000:
993:
987:
984:
977:
974:
963:on 2021-08-29
959:
955:
951:
945:
942:
931:
929:
920:
914:
912:
908:
903:
899:
895:
891:
887:
883:
876:
873:
862:
860:
851:
845:
842:
838:
837:public domain
827:
825:
819:
813:
811:
807:
796:on 2016-09-08
792:
788:
786:
778:
772:
770:
766:
761:
757:
754:(3): 329–36.
753:
749:
742:
739:
726:
725:
724:Health Canada
720:
714:
711:
698:
694:
688:
685:
672:
668:
662:
659:
647:
643:
639:
633:
630:
623:
621:
619:
615:
611:
607:
599:
597:
595:
591:
587:
583:
578:
570:
568:
566:
558:
556:
554:
545:
540:
538:
532:
529:
526:
523:
520:
518:muscle spasms
517:
514:
511:
510:
509:
503:
502:oropharyngeal
500:
499:
498:
492:
490:
487:
483:
479:
471:
466:
464:
462:
456:
454:
449:
447:
446:exacerbations
443:
438:
436:
432:
428:
424:
420:
416:
412:
411:interleukin-5
408:
404:
400:
396:
386:
379:
373:
366:
362:
361:
359:
357:
353:
346:
342:
341:
339:
337:
333:
326:
325:
323:
321:
317:
310:
306:
305:
303:
301:
297:
290:
286:
285:
283:
281:
277:
272:
268:
266:
259:
256:
253:
251:
247:
243:
239:
233: Rx-only
226:
223:
211:
209:
200:
197:
187:
186:
184:
182:
178:
173:
165:
160:
157:
156:
154:
152:
148:
145:
142:
140:
134:
127:
122:
113:
112:
110:
108:
104:
100:
96:
94:
90:
86:
82:
80:
76:
73:Clinical data
71:
68:
65:
63:
59:
55:
51:
48:
46:
42:
38:
36:
32:
29:
25:
4882:
4870:M-CSFR/CSF1R
4857:heterodimer)
4843:heterodimer)
4772:Antagonists:
4771:
4743:
4722:
4701:
4661:
4640:
4613:Risankizumab
4594:
4584:
4562:
4552:
4535:NNC0114-0006
4530:NNC0114-0005
4526:
4511:
4489:
4469:
4448:
4423:
4377:
4342:
4316:
4299:Tralokinumab
4294:Lebrikizumab
4289:Anrukinzumab
4285:
4260:
4234:
4219:
4193:
4167:
4146:
4136:
4095:
4038:Clazakizumab
4029:
4014:
3993:
3986:
3977:Benralizumab
3973:
3964:Antagonists:
3963:
3953:
3936:Pascolizumab
3927:
3918:Antagonists:
3917:
3897:
3851:
3820:
3775:
3754:
3734:
3710:Antagonists:
3709:
3680:
3508:Risankizumab
3493:Lebrikizumab
3473:Clazakizumab
3463:Anrukinzumab
3442:Tralokinumab
3358:Otelixizumab
3338:
3330:
3329:
3299:Tregalizumab
3284:Tislelizumab
3254:Satralizumab
3234:Rontalizumab
3229:Retifanlimab
3223:
3204:Plozalizumab
3184:Pateclizumab
3179:Pascolizumab
3174:Ozoralizumab
3124:Lampalizumab
3114:Inebilizumab
3104:Fontolizumab
3054:Camrelizumab
3049:Benralizumab
3044:Atezolizumab
3030:
2973:Clenoliximab
2874:
2858:Bertilimumab
2853:
2842:Tremelimumab
2822:
2745:Mavrilimumab
2735:Lirentelimab
2730:Lerdelimumab
2705:Fresolimumab
2645:Atorolimumab
2623:
2555:Upadacitinib
2515:Satralizumab
2500:Ritlecitinib
2495:Risankizumab
2290:
2271:
2211:Teprotumumab
2185:
2161:Inebilizumab
2156:Fontolizumab
2136:Atorolimumab
2104:T-lymphocyte
2102:
2076:
2060:
2046:
2027:
2016:Lerdelimumab
2011:Bertilimumab
2003:
1991:
1970:
1956:
1942:
1928:
1909:
1890:
1874:Pascolizumab
1859:Obinutuzumab
1851:
1837:
1823:
1807:Clenoliximab
1799:
1783:Otelixizumab
1770:
1743:
1730:Lebrikizumab
1714:
1698:
1682:
1666:
1650:
1607:Satralizumab
1597:Risankizumab
1529:
1488:
1472:
1464:Serum target
1416:Temsirolimus
1342:
1333:Pomalidomide
1328:Lenalidomide
1286:Pimecrolimus
1265:
1239:Methotrexate
1231:
1209:
1196:Azathioprine
1188:
1173:(initiation)
1111:. Retrieved
1107:the original
1102:
1093:
1082:. Retrieved
1080:. 2010-02-23
1077:
1068:
1049:
1024:
1020:
1013:
1002:. Retrieved
998:
986:
976:
965:. Retrieved
958:the original
953:
944:
933:. Retrieved
925:
885:
881:
875:
864:. Retrieved
856:
844:
821:
798:. Retrieved
791:the original
783:
751:
747:
741:
729:. Retrieved
722:
713:
701:. Retrieved
696:
687:
675:. Retrieved
670:
661:
649:. Retrieved
641:
632:
603:
574:
562:
549:
541:Pharmacology
535:
507:
496:
475:
467:Medical uses
457:
450:
439:
402:
398:
394:
393:
382:
376:
262:Elimination
181:Legal status
175:Legal status
107:License data
4623:Ustekinumab
4603:Briakinumab
4595:Antibodies:
4566:Fezakinumab
4563:Antibodies:
4527:Antibodies:
4515:Denenicokin
4490:Antibodies:
4427:Iboctadekin
4406:Vunakizumab
4401:Secukinumab
4391:Perakizumab
4378:Antibodies:
4286:Antibodies:
4243:Ustekinumab
4238:Briakinumab
4235:Antibodies:
4147:Antibodies:
4073:Tocilizumab
4043:Elsilimomab
4030:Antibodies:
3982:Mepolizumab
3974:Antibodies:
3928:Antibodies:
3855:Daniplestim
3824:Basiliximab
3821:Antibodies:
3789:Celmoleukin
3784:Aldesleukin
3748:Lutikizumab
3743:Gevokizumab
3738:Canakinumab
3735:Antibodies:
3604:from market
3574:Lemalesomab
3569:Fanolesomab
3564:Besilesomab
3503:Perakizumab
3488:Mirikizumab
3478:Gevokizumab
3468:Bimekizumab
3447:Ustekinumab
3432:Secukinumab
3417:Fezakinumab
3412:Canakinumab
3407:Briakinumab
3382:Interleukin
3335:Dostarlimab
3314:Visilizumab
3309:Vedolizumab
3304:Vatelizumab
3294:Toralizumab
3289:Tocilizumab
3274:Teclistamab
3249:Samalizumab
3239:Rovelizumab
3219:Ravulizumab
3199:Pidilizumab
3194:Pexelizumab
3159:Ocrelizumab
3154:Natalizumab
3144:Mepolizumab
3134:Ligelizumab
3129:Letolizumab
3099:Etrolizumab
3089:Epratuzumab
3059:Cedelizumab
3013:Vapaliximab
3008:Teneliximab
2998:Lumiliximab
2983:Gomiliximab
2968:Basiliximab
2940:Vepalimomab
2925:Nerelimomab
2910:Gavilimomab
2905:Faralimomab
2900:Elsilimomab
2875:Combination
2868:Zanolimumab
2863:Ontamalimab
2811:Ulocuplumab
2806:Tezepelumab
2796:Sifalimumab
2776:Pamrevlumab
2755:Morolimumab
2750:Metelimumab
2720:Lanadelumab
2655:Avdoralimab
2640:Anifrolumab
2550:Tofacitinib
2490:Ravulizumab
2480:Pirfenidone
2470:Peficitinib
2370:Canakinumab
2360:Briakinumab
2350:Bimekizumab
2345:Baricitinib
2310:Aflibercept
2221:Vepalimomab
2216:Vapaliximab
2191:Rovelizumab
2181:Pexelizumab
2171:Morolimumab
2146:Cedelizumab
2131:Anifrolumab
2126:Alemtuzumab
2084:Basiliximab
2054:Tocilizumab
2040:Vedolizumab
2035:Natalizumab
2021:Metelimumab
1964:Gavilimomab
1922:Toralizumab
1917:Teneliximab
1903:Lumiliximab
1898:Gomiliximab
1884:Ublituximab
1864:Ocrelizumab
1817:Zanolimumab
1793:Visilizumab
1751:Secukinumab
1735:Ustekinumab
1706:Elsilimomab
1690:Faralimomab
1658:Mepolizumab
1642:Ustekinumab
1637:Tocilizumab
1612:Secukinumab
1562:Canakinumab
1552:Briakinumab
1547:Bimekizumab
1542:Basiliximab
1531:Interleukin
1521:Nerelimomab
1426:Zotarolimus
1367:(reception)
1338:Thalidomide
1296:Voclosporin
1281:Ciclosporin
1275:Calcineurin
1271:Cyclophilin
1218:Leflunomide
1214:inhibitors
1019:3 trials".
594:amino acids
588:into small
586:proteolysis
527:anaphylaxis
419:eosinophils
289:241473-69-8
274:Identifiers
255:Proteolysis
144:Intravenous
79:Trade names
4932:Categories
4678:B (IFN-λ3)
4674:A (IFN-λ2)
4608:Guselkumab
4598:Brazikumab
4493:Fletikumab
4396:Remtolumab
4386:Ixekizumab
4381:Brodalumab
4264:Binetrakin
4202:Oprelvekin
4171:Ilodecakin
4150:Enokizumab
4063:Siltuximab
4053:Olokizumab
3987:Reslizumab
3921:Pitrakinra
3901:Binetrakin
3870:Milodistim
3865:Leridistim
3834:Inolimomab
3809:Teceleukin
3728:Isunakinra
3665:modulators
3534:Lokivetmab
3527:Veterinary
3513:Spesolimab
3498:Olokizumab
3483:Ixekizumab
3427:Guselkumab
3422:Fletikumab
3402:Brazikumab
3397:Bermekimab
3368:Sutimlimab
3342:Ibalizumab
3279:Teplizumab
3259:Siplizumab
3244:Ruplizumab
3224:Reslizumab
3214:Quilizumab
3169:Omalizumab
3119:Itolizumab
3109:Frexalimab
3084:Efalizumab
3079:Eculizumab
3074:Daclizumab
3039:Aselizumab
3034:Apolizumab
3003:Priliximab
2988:Infliximab
2930:Odulimomab
2920:Maslimomab
2915:Inolimomab
2895:Afelimomab
2832:Durvalumab
2827:Ipilimumab
2816:Varlilumab
2786:Relatlimab
2781:Placulumab
2725:Lenzilumab
2700:Emapalumab
2685:Cemiplimab
2670:Brodalumab
2665:Bleselumab
2635:Adalimumab
2540:Sutimlimab
2535:Spesolimab
2520:Siltuximab
2460:Olokizumab
2450:Ixekizumab
2445:Itacitinib
2435:Guselkumab
2430:Fingolimod
2425:Filgotinib
2375:Crovalimab
2365:Brodalumab
2355:Blisibimod
2320:Rilonacept
2303:Opinercept
2298:Etanercept
2284:Belatacept
2235:Polyclonal
2196:Siplizumab
2186:Reslizumab
2176:Ofatumumab
2166:Maslimomab
2151:Emapalumab
2094:Inolimomab
2089:Daclizumab
2068:Odulimomab
1983:Ruplizumab
1978:Frexalimab
1936:Aselizumab
1831:Efalizumab
1788:Teplizumab
1684:Interferon
1674:Omalizumab
1627:Spesolimab
1617:Siltuximab
1592:Rilonacept
1587:Olokizumab
1577:Ixekizumab
1572:Guselkumab
1567:Daclizumab
1557:Brodalumab
1516:Infliximab
1501:Afelimomab
1496:Adalimumab
1480:Eculizumab
1456:Monoclonal
1447:Antibodies
1421:Umirolimus
1401:Everolimus
1350:Apremilast
1310:Gusperimus
1291:Tacrolimus
1259:inhibitors
1251:Macrolides
1233:antifolate
1113:2016-11-22
1084:2016-11-22
1004:2016-11-22
967:2016-11-22
935:2016-11-22
866:2016-11-22
800:2016-11-22
624:References
531:malignancy
395:Reslizumab
345:35A26E427H
320:ChemSpider
280:CAS Number
250:Metabolism
126:Reslizumab
21:Reslizumab
4883:Unsorted:
4744:Agonists:
4723:Agonists:
4702:Agonists:
4662:Agonists:
4641:Agonists:
4585:Agonists:
4553:Agonists:
4512:Agonists:
4470:Agonists:
4442:Tadekinig
4424:Agonists:
4343:Agonists:
4317:Agonists:
4261:Agonists:
4220:Agonists:
4194:Agonists:
4168:Agonists:
4137:Agonists:
4096:Agonists:
4078:Levilimab
4068:Sirukumab
4058:Sarilumab
4015:Agonists:
3954:Agonists:
3931:Dupilumab
3898:Agonists:
3875:Muplestim
3852:Agonists:
3776:Agonists:
3703:Pifonakin
3698:Mobenakin
3681:Agonists:
3614:Phase III
3602:Withdrawn
3579:Sulesomab
3456:Humanized
3437:Sirukumab
3269:Talizumab
3094:Erlizumab
3023:Humanized
2993:Keliximab
2978:Galiximab
2837:Nivolumab
2801:Tabalumab
2791:Sarilumab
2765:Oleclumab
2760:Namilumab
2740:Lirilumab
2715:Ianalumab
2710:Golimumab
2695:Eldelumab
2690:Dupilumab
2660:Belimumab
2630:Abrilumab
2530:Sirukumab
2525:Siponimod
2510:Sarilumab
2485:Ponesimod
2455:Netakimab
2440:Iptacopan
2420:Etrasimod
2380:Danicopan
2315:Alefacept
2279:Abatacept
2201:Talizumab
2141:Begelomab
1997:Belimumab
1950:Galiximab
1879:Rituximab
1845:Erlizumab
1812:Keliximab
1622:Sirukumab
1602:Sarilumab
1582:Netakimab
1511:Golimumab
1411:Sirolimus
515:neck pain
264:half-life
137:Routes of
99:Monograph
93:Drugs.com
50:Humanized
4922:Medicine
4837:IL-22Rα1
4803:instead.
4120:instead.
4048:mAb 1339
4033:ARGX-109
3997:TPI ASM8
3967:YM-90709
3718:Anakinra
3713:AF-12198
2955:Chimeric
2847:Urelumab
2770:Oxelumab
2680:Carlumab
2650:Avelumab
2599:for the
2465:Ozanimod
2340:Avacopan
2333:Unsorted
2119:Unsorted
2029:Integrin
1762:Cellular
1537:Anakinra
1383:Anakinra
1305:Abetimus
1157: /
1041:25736990
902:21852542
760:19479666
703:31 March
614:Cephalon
590:peptides
415:cytokine
403:Cinqaero
385:(verify)
300:DrugBank
269:~24 days
151:ATC code
121:DailyMed
4855:IL-10Rβ
4851:IL-20Rα
4841:IL-20Rβ
4775:IL-36RA
4320:ALT-803
3549:lesions
3324:TGN1412
3209:PRO 140
2261:-cept (
731:7 April
677:9 April
600:History
486:placebo
461:sucrose
431:myalgia
405:, is a
399:Cinqair
309:DB06602
224:Rx-only
221:WARNING
206::
167:)
161: (
159:R03DX08
123::
4908:Portal
4811:Others
4784:Others
4736:IL1RL2
4715:IL1RL1
4452:IL18BP
3723:IL-1RA
3597:WHO-EM
3339:Other:
2273:CTLA-4
2263:Fusion
1764:target
1745:IL-17A
1722:, and
1255:other
1061:
1039:
900:
758:
651:22 Oct
482:sputum
365:D08985
218:
208:℞-only
194:
119:
62:Target
52:(from
45:Source
4694:IL-31
4654:IL-28
4633:IL-27
4577:IL-23
4545:IL-22
4504:IL-21
4462:IL-20
4416:IL-18
4335:IL-17
4309:IL-15
4253:IL-13
4212:IL-12
4186:IL-11
4160:IL-10
3557:Mouse
3390:Human
2888:Mouse
2854:Other
2617:Human
2062:LFA-1
1972:CD154
1825:CD11a
1724:IL-23
1720:IL-13
1716:IL-12
1320:IMiDs
995:(PDF)
961:(PDF)
930:(FDA)
926:U.S.
922:(PDF)
861:(FDA)
857:U.S.
853:(PDF)
826:(FDA)
822:U.S.
794:(PDF)
787:(EMA)
780:(PDF)
4801:here
4799:See
4129:IL-9
4118:here
4109:IL-8
4088:IL-7
4007:IL-6
3946:IL-5
3890:IL-4
3844:IL-3
3768:IL-2
3673:IL-1
1992:BLyS
1944:CD80
1911:CD40
1892:CD23
1853:CD20
1839:CD18
1700:IL-6
1393:mTOR
1267:FKBP
1257:IL-2
1037:PMID
898:PMID
756:PMID
733:2024
705:2024
679:2023
653:2023
592:and
575:The
504:pain
433:and
401:and
356:KEGG
336:UNII
327:none
244:data
89:AHFS
67:IL-5
35:Type
4827:CD4
4792:JAK
2005:CAT
1801:CD4
1772:CD3
1490:TNF
1163:L04
1029:doi
890:doi
886:184
646:FDA
164:WHO
54:rat
4934::
4757:,
4753:,
4676:,
4368:,
4364:,
4360:,
4356:,
4352:,
3690:,
3610::
3333::
2877::
2856::
2825::
2628::
1718:,
1101:.
1076:.
1035:.
1023:.
997:.
952:.
924:.
910:^
896:.
884:.
855:.
820:.
809:^
782:.
768:^
752:11
750:.
721:.
695:.
669:.
644:.
640:.
565:μL
553:pM
437:.
429:,
229:EU
214:US
203:CA
196:S4
190:AU
116:US
4910::
4872:)
4853:/
4839:/
4829:)
4761:)
4759:γ
4755:β
4751:α
4749:(
4680:)
4672:(
4372:)
4370:F
4362:D
4358:C
4354:B
4350:A
4348:(
3694:)
3692:β
3688:α
3686:(
3654:e
3647:t
3640:v
3165:)
3161:(
2772:§
2589:e
2582:t
2575:v
2416:)
2412:(
2265:)
2111:)
2107:(
1870:)
1866:(
1273:/
1269:/
1253:/
1165:)
1161:(
1147:e
1140:t
1133:v
1116:.
1087:.
1043:.
1031::
1025:3
1007:.
970:.
938:.
904:.
892::
869:.
839:.
803:.
762:.
735:.
707:.
681:.
655:.
231::
216::
192::
91:/
56:)
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