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several months or years. The mononuclear phagocyte system is part of both humoral and cell-mediated immunity. The mononuclear phagocyte system has an important role in defense against microorganisms, including mycobacteria, fungi, bacteria, protozoa, and viruses. Macrophages remove senescent erythrocytes, leukocytes, and
139:
Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous system (microglia). The half-life of blood monocytes is about 1 day, whereas the life span of tissue macrophages is
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is the second largest unit of the mononuclear phagocyte system. The monocyte is formed in the bone marrow and transported by the blood; it migrates into the tissues, where it transforms into a histiocyte or a macrophage.
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are also part of the MPS. The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one.
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The mononuclear phagocyte system is also a somewhat dated concept trying to combine a broad range of cells, and should be used with caution.
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112:" is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most
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from the breakdown of red blood cells. In bone marrow and spleen, iron is stored in MPS cells mostly as
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The various cell types of the mononuclear phagocyte system are all part of the
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411:(precursor of granulocytes, erythrocytes, monocytes and megakaryocytes)
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Formation of new red blood cells (RBCs) and white blood cells (WBCs).
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Storage of iron. In the liver, Kupffer cells store excess iron from
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Hume, David A (2006-02-01). "The mononuclear phagocyte system".
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383:; in iron overload states, most of the iron is stored as
482:. Innate immunity / Antigen processing and recognition.
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450:. Jaypee Brothers Publishers. pp. 90–.
515:Principles of Renal Physiology, 5th edition
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430:at the U.S. National Library of Medicine
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1071:Megakaryocyte–erythroid progenitor cell
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362:Destruction of senescent RBCs.
288:Intraglomerular mesangial cell
1:
480:Current Opinion in Immunology
365:Formation of plasma proteins.
55:mononuclear phagocytic system
762:Extramedullary hematopoiesis
428:Mononuclear+Phagocyte+System
51:mononuclear phagocyte system
447:Textbook of human histology
368:Formation of bile pigments.
75:reticular connective tissue
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163:Adipose tissue macrophages
110:Reticuloendothelial system
77:. The cells are primarily
40:reticuloendothelial system
29:
928:Antigen-presenting cells
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492:10.1016/j.coi.2005.11.008
85:, and they accumulate in
27:Part of the immune system
1016:Nucleated red blood cell
572:Myeloid blood cells and
432:Medical Subject Headings
234:(Histiocyte) leading to
127:Cell types and locations
30:Not to be confused with
1118:Hematopoietic stem cell
1037:Leukocyte extravasation
906:Foreign-body giant cell
517:. Springer. p. 37.
444:Inderbir Singh (2006).
330:Peritoneal macrophages
269:Central Nervous System
513:Lote, Christopher J.
69:that consists of the
1113:Hematopoietic system
901:Langhans giant cells
61:) also known as the
876:Alveolar macrophage
313:Red Pulp Macrophage
215:Alveolar macrophage
18:Reticuloendothelial
1047:Intrinsic immunity
911:Touton giant cells
241:Connective Tissues
232:Tissue macrophages
221:Pulmonary alveolus
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891:Epithelioid cells
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532:Immunology at MCG
457:978-81-8061-809-3
407:lineage from the
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334:Peritoneal cavity
203:Sinus histiocytes
65:is a part of the
63:macrophage system
16:(Redirected from
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1062:Precursor cells
988:Promegakaryocyte
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1042:Phagocytosis
1011:Reticulocyte
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785:Granulocytes
736:Reticulocyte
628:Promyelocyte
591:Myelopoiesis
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486:(1): 49–53.
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461:. Retrieved
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322:Red pulp of
191:Kupffer cell
146:phagocytosis
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32:reticulocyte
896:giant cells
886:Osteoclasts
866:Histiocytes
858:Macrophages
668:Promonocyte
463:12 November
385:hemosiderin
300:Epithelioid
236:Giant cells
217:(dust cell)
180:Bone Marrow
118:macrophages
114:endothelial
103:histiocytes
101:and tissue
87:lymph nodes
83:macrophages
73:located in
820:Eosinophil
803:Neutrophil
793:Myeloblast
731:Normoblast
623:Myeloblast
536:1/reticulo
415:References
373:catabolism
341:Osteoclast
317:Sinusoidal
306:Granulomas
302:histiocyte
208:Lymph node
47:immunology
1103:Phagocyte
970:Platelets
949:Monoblast
881:Microglia
849:Monocytes
832:Mast cell
798:Band cell
663:Monoblast
643:Band cell
633:Myelocyte
354:Functions
264:Microglia
157:Location
154:Cell Name
79:monocytes
1135:Category
1076:CFU-GEMM
837:CFU-Mast
813:CFU-Baso
808:Basophil
596:CFU-GEMM
500:16338128
409:CFU-GEMM
381:ferritin
281:Placenta
175:Monocyte
89:and the
978:CFU-Meg
825:CFU-Eos
755:General
405:myeloid
392:heparin
97:of the
1108:Plasma
1066:CFU-GM
942:CFU-DL
606:CFU-GM
574:plasma
498:
454:
434:(MeSH)
324:Spleen
293:Kidney
257:Mucosa
133:spleen
93:. The
91:spleen
49:, the
1096:Other
1056:Other
1021:CFU-E
922:Other
225:Lungs
196:Liver
184:Blood
99:liver
38:, or
496:PMID
465:2010
452:ISBN
377:heme
346:Bone
255:and
253:Skin
131:The
81:and
954:MPS
684:MEP
488:doi
375:of
223:of
144:by
59:MPS
53:or
45:In
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