244:
221:
118:
143:
495:
250:
149:
1168:, the cells in the ICM have been found to be a heterogenous population, with varying levels of Rex1 expression. Rex1/Oct3/4 triggers trophectoderm differentiation, while Rex1/Oct3/4 cells predominantly differentiate into primitive endoderm and
1098:
MSC expressed low levels of Rex1. Proliferation rates are highly correlated with Rex1 expression levels, meaning high Rex1 expression is correlated with high levels of proliferation. The MSCs with weak Rex1 expression, have activated
1131:, two transcription factors which lead to differentiation. Therefore, Rex1 expression allows for high levels of proliferation, and prevents differentiation through a network of various transcription factors and protein kinases.
2132:
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".
2172:"Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro"
2213:
Mongan NP, Martin KM, Gudas LJ (December 2006). "The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures".
2080:"Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site"
2040:
Rogers MB, Hosler BA, Gudas LJ (November 1991). "Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes".
2251:
257:
156:
1847:
Toyooka Y, Shimosato D, Murakami K, Takahashi K, Niwa H (March 2008). "Identification and characterization of subpopulations in undifferentiated ES cell culture".
1514:
Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH (November 2006). "A protein interaction network for pluripotency of embryonic stem cells".
1296:
expression. Nanog regulates the transcription of Rex1 through 2 strong transactivation domains on the C-terminus which are required to activate the Rex1
714:
1804:
Niwa H, Miyazaki J, Smith AG (April 2000). "Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells".
733:
79:
1248:
are the specific cells in the testicles that express Rex1. It has not been observed, however, that Rex1 is expressed in the female germ cells.
1430:
1448:
1120:
1116:
1108:
1100:
2347:
1220:
gene unmethylated during early embryogenesis. Rex1 exhibits gene control in developing embryos via its epigenetic control on genes such as
1035:. They found that these teratocarcinoma stem cells expressed high levels of Rex1, and that they resembled pluripotent stem cells of the
941:
243:
948:
1706:"REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells"
1683:
220:
1568:
1074:. The Rex1 protein is 310 amino acids long, and has four closely spaced zinc fingers at 188–212, 217–239, 245–269, and 275–299.
1417:
1396:
1351:
can both repress and activate the Rex1 promoter. In cells that already express high level of Oct3/4, exogenously transfected
1587:"Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells"
1413:
1256:
Rex1 participates in a network of transcription factors that all work to regulate each other via varying expression levels.
142:
117:
1392:
1636:"Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens"
59:
1371:
protein, the Rex1 promoter is activated, while at high levels of the Oct3/4 protein, the Rex1 promoter is repressed.
256:
155:
2296:"Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression"
1763:
Garcia-Tuñon I, Guallar D, Alonso-Martin S, Benito AA, Benítez-Lázaro A, Pérez-Palacios R, et al. (July 2011).
2252:"Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression"
1048:
249:
148:
1016:
778:
67:
1309:
1124:
759:
1337:
1289:
1277:
1265:
1237:
1083:
1717:
1523:
1051:
of an F9 cell. They named it Rex1 for reduced expression 1 because there was a steady decline of its
131:
46:
1244:
in the more inner layers of the testicles are expressing Rex1. Thus, the male germ cells undergoing
2352:
1297:
1281:
1008:
899:
848:
2170:
Moriscot C, de
Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, et al. (April 2005).
1156:. The stem cells derived from the ICM and trophectoderm have been found to express high levels of
2282:
2238:
2201:
2158:
1872:
1829:
1665:
1547:
91:
924:
903:
873:
852:
494:
1111:
activation, and positively correlated with high proliferation rates. Rex1 was found to inhibit
2325:
2274:
2230:
2193:
2150:
2109:
2057:
2022:
1973:
1924:
1864:
1821:
1786:
1745:
1657:
1616:
1539:
1496:
1039:(ICM). Hosler, BA et al. found that these teratocarcinoma stem cells, when in the presence of
39:
2315:
2307:
2266:
2222:
2183:
2142:
2099:
2091:
2049:
2012:
2004:
1963:
1955:
1914:
1906:
1856:
1813:
1776:
1735:
1725:
1647:
1606:
1598:
1531:
1486:
1015:, its regulation is also critical in maintaining a pluripotent state. As the cells begin to
336:
267:
211:
166:
1634:
Henderson JK, Draper JS, Baillie HS, Fishel S, Thomson JA, Moore H, Andrews PW (Jul 2002).
87:
16:
Known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells
1149:
1036:
311:
1047:
of early mouse embryos. They were able to isolate the nucleotide sequence for Rex1 using
1721:
1527:
1355:
will lead to the repression of Rex1. However, in cells that are not actively expressing
2320:
2295:
2017:
1992:
1968:
1943:
1919:
1894:
1740:
1705:
1091:
1087:
2104:
2079:
1993:"Coadaptation in mother and infant regulated by a paternally expressed imprinted gene"
1765:"Association of Rex-1 to target genes supports its interaction with Polycomb function"
1611:
1586:
648:
643:
638:
633:
628:
623:
618:
602:
597:
592:
587:
571:
566:
561:
556:
551:
546:
541:
536:
2341:
1241:
1145:
1082:
Rex1 has been found to be critically important in maintaining proliferative state in
1052:
1040:
523:
2286:
2242:
2162:
1876:
1833:
2205:
1669:
1551:
1173:
1012:
1004:
329:
108:
71:
1730:
1704:
Bhandari DR, Seo KW, Roh KH, Jung JW, Kang SK, Kang KS (May 2010). Pera M (ed.).
95:
2311:
2188:
1453:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1435:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1363:
will lead to the activation of Rex1. This implies a dual regulatory ability of
1201:
1153:
1095:
2171:
1652:
1635:
412:
1781:
1764:
1193:
1172:. Also, Rex1/Oct3/4 cells differentiate into cells of primitive ectoderm, the
1032:
228:
125:
75:
1233:
1209:
1192:
are downstream targets of Rex1. Rex1 can control the expression of Peg3 via
678:
472:
350:
295:
282:
194:
181:
83:
2329:
2278:
2234:
2197:
2154:
2026:
2008:
1977:
1928:
1868:
1825:
1790:
1749:
1661:
1543:
1500:
1491:
1474:
2113:
2095:
2061:
2053:
1620:
1602:
988:
983:
1959:
1910:
1224:, which has been identified as playing a key role in fetal growth rates
1169:
1165:
1161:
1044:
1043:(RA), differentiated into nontumorigenic cells resembling extraembryonic
972:
823:
804:
1535:
567:
DNA-binding transcription repressor activity, RNA polymerase II-specific
1860:
1245:
1064:
1028:
790:
745:
2270:
2294:
Rezende NC, Lee MY, Monette S, Mark W, Lu A, Gudas LJ (August 2011).
2226:
1368:
1364:
1360:
1356:
1352:
1348:
1213:
1157:
956:
700:
562:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
557:
DNA-binding transcription factor activity, RNA polymerase II-specific
2146:
1817:
1321:
1128:
1123:, in turn, inhibits proliferation. Rex1 was also found to inhibit
1027:
Rex1 was discovered by Hosler, BA et al. in 1989 when studying F9
1268:
protein has been found to be a transcriptional activator for the
663:
659:
503:
1333:
1221:
1217:
1205:
1185:
1112:
1104:
1071:
63:
1475:"Regulation of the pluripotency marker Rex-1 by Nanog and Sox2"
2078:
Ben-Shushan E, Thompson JR, Gudas LJ, Bergman Y (April 1998).
1895:"Rex1/Zfp42 as an epigenetic regulator for genomic imprinting"
1197:
50:, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein
1086:(MSC), while simultaneously preventing differentiation. Both
1893:
Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J (April 2011).
1684:"Entrez Gene: ZFP42 zinc finger protein 42 homolog (mouse)"
1585:
Hosler BA, LaRosa GJ, Grippo JF, Gudas LJ (December 1989).
1473:
Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D (August 2006).
1232:
The only adult tissue Rex1 has been identified in are the
649:
negative regulation of transcription by RNA polymerase II
319:
1991:
Curley JP, Barton S, Surani A, Keverne EB (June 2004).
1107:. Thus, Rex1 expression is inversely correlated with
484:
1160:
and Rex1. As the ICM matures and begins to form the
917:
892:
866:
841:
1563:
1561:
1409:
1407:
1405:
1388:
1386:
1384:
1252:Rex1 Interactions with Other Transcription Factors
1320:Rex1 has been found to inhibit the expression of
1308:Rex1 has been found to inhibit the expression of
266:
165:
1944:"YY1's role in DNA methylation of Peg3 and Xist"
1200:has been shown to be involved in setting up DNA
644:regulation of transcription by RNA polymerase II
1888:
1886:
1699:
1697:
1695:
1693:
1569:"ZooMAb® Antibodies Frequently Asked Questions"
1019:, Rex1 is severely and abruptly downregulated.
2073:
2071:
1468:
1466:
1464:
1462:
1414:GRCm38: Ensembl release 89: ENSMUSG00000051176
1055:levels within 12 hours of the addition of RA.
1580:
1578:
8:
1332:Cooperative regulation of Rex1 is seen with
2250:Roche S, Richard MJ, Favrot MC (May 2007).
1393:GRCh38: Ensembl release 89: ENSG00000179059
1272:promoter, playing a key role in sustaining
1007:, and is usually found in undifferentiated
674:
624:regulation of transcription, DNA-templated
519:
307:
206:
103:
2319:
2187:
2103:
2016:
1967:
1918:
1780:
1739:
1729:
1651:
1610:
1490:
1212:. Rex1 was found to protect the paternal
537:DNA-binding transcription factor activity
1942:Kim JD, Kang K, Kim J (September 2009).
1380:
1288:expression, while forced expression of
1094:MSC express high levels of Rex1, while
20:
1078:p38 MAPK & Mesenchymal Stem Cells
271:
232:
227:
170:
129:
124:
7:
1216:from being methylated, and keep the
1011:. In addition to being a marker for
1479:The Journal of Biological Chemistry
1324:, thus preventing differentiation.
1312:, thus preventing differentiation.
914:
889:
863:
838:
814:
795:
769:
750:
724:
705:
489:
407:
345:
324:
14:
1067:that in humans is encoded by the
2259:Journal of Cellular Biochemistry
1997:Proceedings. Biological Sciences
493:
255:
248:
242:
219:
154:
147:
141:
116:
1359:, an exogenous transfection of
598:transcription regulator complex
2084:Molecular and Cellular Biology
1591:Molecular and Cellular Biology
1367:on Rex1. At low levels of the
1103:and high expression levels of
1003:(Zfp-42) is a known marker of
504:More reference expression data
473:More reference expression data
1:
572:sequence-specific DNA binding
240:
139:
1731:10.1371/journal.pone.0010493
1152:(ICM) is separated from the
1115:expression, which activates
629:transcription, DNA-templated
2348:Genes on human chromosome 4
2312:10.1016/j.ydbio.2011.05.664
2189:10.1634/stemcells.2004-0123
1240:it was determined that the
1228:Expression in Adult Tissues
2369:
1653:10.1634/stemcells.20-4-329
1284:results in a reduction of
1204:on the maternal allele of
1049:differential hybridization
1782:10.1016/j.scr.2011.02.005
1449:"Mouse PubMed Reference:"
1431:"Human PubMed Reference:"
1276:expression. Knockdown of
987:
982:
978:
971:
955:
936:
921:
896:
885:
870:
845:
834:
821:
817:
802:
798:
789:
776:
772:
757:
753:
744:
731:
727:
712:
708:
699:
684:
677:
673:
657:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
2215:Molecular Carcinogenesis
1899:Human Molecular Genetics
1184:Studies have shown that
634:female gonad development
455:male reproductive system
949:Chr 8: 43.75 – 43.76 Mb
2009:10.1098/rspb.2004.2725
1948:Nucleic Acids Research
1492:10.1074/jbc.M601811200
1084:mesenchymal stem cells
942:Chr 4: 188 – 188.01 Mb
619:male gonad development
2300:Developmental Biology
2096:10.1128/mcb.18.4.1866
2054:10.1242/dev.113.3.815
1603:10.1128/mcb.9.12.5623
1238:in situ hybridization
2135:Nature Biotechnology
1282:embryonic stem cells
1009:embryonic stem cells
552:nucleic acid binding
273:8 A4|8 23.89 cM
234:Chromosome 8 (mouse)
132:Chromosome 4 (human)
2003:(1545): 1303–1309.
1722:2010PLoSO...510493B
1536:10.1038/nature05284
1528:2006Natur.444..364W
1485:(33): 23319–23325.
603:PcG protein complex
1960:10.1093/nar/gkp613
1911:10.1093/hmg/ddr017
1861:10.1242/dev.017400
1769:Stem Cell Research
1135:Embryo Development
779:ENSMUSG00000051176
612:Biological process
581:Cellular component
530:Molecular function
361:buccal mucosa cell
2271:10.1002/jcb.21185
1954:(17): 5656–5664.
1597:(12): 5623–5629.
1522:(7117): 364–368.
1140:Tissue Derivation
998:
997:
994:
993:
967:
966:
932:
931:
911:
910:
881:
880:
860:
859:
830:
829:
811:
810:
785:
784:
766:
765:
740:
739:
721:
720:
669:
668:
547:metal ion binding
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
96:ZFP42 - orthologs
2360:
2333:
2323:
2290:
2256:
2246:
2227:10.1002/mc.20186
2209:
2191:
2166:
2118:
2117:
2107:
2090:(4): 1866–1878.
2075:
2066:
2065:
2037:
2031:
2030:
2020:
1988:
1982:
1981:
1971:
1939:
1933:
1932:
1922:
1905:(7): 1353–1362.
1890:
1881:
1880:
1844:
1838:
1837:
1801:
1795:
1794:
1784:
1760:
1754:
1753:
1743:
1733:
1701:
1688:
1687:
1680:
1674:
1673:
1655:
1631:
1625:
1624:
1614:
1582:
1573:
1572:
1565:
1556:
1555:
1511:
1505:
1504:
1494:
1470:
1457:
1456:
1445:
1439:
1438:
1427:
1421:
1411:
1400:
1390:
1164:, and primitive
1031:teratocarcinoma
980:
979:
951:
944:
927:
915:
906:
890:
886:RefSeq (protein)
876:
864:
855:
839:
815:
796:
770:
751:
725:
706:
675:
520:
506:
497:
490:
475:
415:
413:Top expressed in
408:
397:ventricular zone
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
2368:
2367:
2363:
2362:
2361:
2359:
2358:
2357:
2338:
2337:
2336:
2293:
2254:
2249:
2221:(12): 887–900.
2212:
2169:
2131:
2127:
2125:Further reading
2122:
2121:
2077:
2076:
2069:
2039:
2038:
2034:
1990:
1989:
1985:
1941:
1940:
1936:
1892:
1891:
1884:
1846:
1845:
1841:
1806:Nature Genetics
1803:
1802:
1798:
1762:
1761:
1757:
1703:
1702:
1691:
1682:
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1677:
1633:
1632:
1628:
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1513:
1512:
1508:
1472:
1471:
1460:
1447:
1446:
1442:
1429:
1428:
1424:
1412:
1403:
1391:
1382:
1377:
1346:
1330:
1318:
1306:
1262:
1254:
1230:
1182:
1150:inner cell mass
1142:
1137:
1080:
1061:
1037:inner cell mass
1025:
989:View/Edit Mouse
984:View/Edit Human
947:
940:
937:Location (UCSC)
923:
902:
898:
872:
851:
847:
760:ENSG00000179059
653:
607:
576:
502:
471:
462:
457:
453:
451:male human body
449:
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437:
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429:
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411:
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379:
375:
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210:Gene location (
192:
179:
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161:
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159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
2366:
2364:
2356:
2355:
2350:
2340:
2339:
2335:
2334:
2306:(2): 370–382.
2291:
2265:(2): 271–280.
2247:
2210:
2182:(4): 594–603.
2167:
2147:10.1038/nbt971
2141:(6): 707–716.
2128:
2126:
2123:
2120:
2119:
2067:
2048:(3): 815–824.
2032:
1983:
1934:
1882:
1855:(5): 909–918.
1839:
1812:(4): 372–376.
1796:
1755:
1689:
1675:
1646:(4): 329–337.
1626:
1574:
1557:
1506:
1458:
1440:
1422:
1401:
1379:
1378:
1376:
1373:
1345:
1342:
1329:
1326:
1317:
1314:
1305:
1302:
1261:
1258:
1253:
1250:
1229:
1226:
1181:
1178:
1141:
1138:
1136:
1133:
1090:blood MSC and
1088:umbilical cord
1079:
1076:
1060:
1057:
1024:
1021:
996:
995:
992:
991:
986:
976:
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968:
965:
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719:
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710:
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703:
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402:
401:
399:
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394:
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386:
382:
378:
374:
370:
369:amniotic fluid
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
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287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
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2253:
2248:
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2240:
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2216:
2211:
2207:
2203:
2199:
2195:
2190:
2185:
2181:
2177:
2173:
2168:
2164:
2160:
2156:
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2140:
2136:
2130:
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2124:
2115:
2111:
2106:
2101:
2097:
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2089:
2085:
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2074:
2072:
2068:
2063:
2059:
2055:
2051:
2047:
2043:
2036:
2033:
2028:
2024:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1987:
1984:
1979:
1975:
1970:
1965:
1961:
1957:
1953:
1949:
1945:
1938:
1935:
1930:
1926:
1921:
1916:
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1896:
1889:
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1878:
1874:
1870:
1866:
1862:
1858:
1854:
1850:
1843:
1840:
1835:
1831:
1827:
1823:
1819:
1818:10.1038/74199
1815:
1811:
1807:
1800:
1797:
1792:
1788:
1783:
1778:
1774:
1770:
1766:
1759:
1756:
1751:
1747:
1742:
1737:
1732:
1727:
1723:
1719:
1716:(5): e10493.
1715:
1711:
1707:
1700:
1698:
1696:
1694:
1690:
1685:
1679:
1676:
1671:
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1649:
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1596:
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1564:
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1549:
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1498:
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1299:
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1287:
1283:
1279:
1275:
1271:
1267:
1259:
1257:
1251:
1249:
1247:
1243:
1242:spermatocytes
1239:
1235:
1227:
1225:
1223:
1219:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1179:
1177:
1175:
1171:
1167:
1163:
1159:
1155:
1151:
1147:
1146:embryogenesis
1139:
1134:
1132:
1130:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1097:
1093:
1089:
1085:
1077:
1075:
1073:
1070:
1066:
1058:
1056:
1054:
1050:
1046:
1042:
1041:retinoic acid
1038:
1034:
1030:
1022:
1020:
1018:
1017:differentiate
1014:
1010:
1006:
1002:
990:
985:
981:
977:
974:
970:
963:
961:
958:
954:
950:
946:
943:
939:
935:
928:
926:
920:
916:
913:
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905:
901:
895:
891:
888:
884:
877:
875:
869:
865:
862:
856:
854:
850:
844:
840:
837:
835:RefSeq (mRNA)
833:
826:
825:
820:
816:
813:
807:
806:
801:
797:
794:
792:
788:
781:
780:
775:
771:
768:
762:
761:
756:
752:
749:
747:
743:
736:
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730:
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723:
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525:
524:Gene ontology
521:
517:
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496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
393:skin of thigh
392:
388:
384:
380:
376:
372:
368:
364:
360:
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356:
352:
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344:
343:
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288:
284:
279:
269:
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258:
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217:
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196:
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183:
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168:
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150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
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85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
2303:
2299:
2262:
2258:
2218:
2214:
2179:
2175:
2138:
2134:
2087:
2083:
2045:
2041:
2035:
2000:
1996:
1986:
1951:
1947:
1937:
1902:
1898:
1852:
1848:
1842:
1809:
1805:
1799:
1772:
1768:
1758:
1713:
1709:
1678:
1643:
1639:
1629:
1594:
1590:
1519:
1515:
1509:
1482:
1478:
1452:
1443:
1434:
1425:
1347:
1331:
1319:
1307:
1293:
1285:
1273:
1269:
1263:
1255:
1231:
1189:
1183:
1180:Gene Control
1174:somatic cell
1143:
1119:. Activated
1081:
1068:
1062:
1026:
1013:pluripotency
1005:pluripotency
1000:
999:
922:
900:NP_001291287
897:
871:
849:NM_001304358
846:
822:
803:
777:
758:
732:
713:
693:
688:
435:spermatocyte
385:right testis
335:
328:
193:188,005,046
180:187,995,771
55:External IDs
18:
2042:Development
1849:Development
1775:(1): 1–16.
1292:stimulates
1202:methylation
1154:trophoblast
1096:bone marrow
542:DNA binding
389:left testis
294:43,760,017
281:43,748,100
33:Identifiers
2353:Stem cells
2342:Categories
2176:Stem Cells
1640:Stem Cells
1420:, May 2017
1399:, May 2017
1375:References
1194:epigenetic
1063:Rex1 is a
1033:stem cells
423:blastocyst
339:(ortholog)
76:HomoloGene
1234:testicles
1210:oogenesis
1196:changes.
1176:lineage.
1059:Structure
1023:Discovery
925:NP_033582
904:NP_777560
874:NM_009556
853:NM_174900
679:Orthologs
588:cytoplasm
84:GeneCards
2330:21641340
2287:44892102
2279:17211834
2243:23613555
2235:16865673
2198:15790780
2163:27764390
2155:15146197
2027:15306355
1978:19628663
1929:21233130
1877:24530633
1869:18263842
1834:33012290
1826:10742100
1791:21530438
1750:20463961
1710:PLOS ONE
1662:12110702
1544:17093407
1501:16714766
1416:–
1395:–
1298:promoter
1236:. Using
1170:mesoderm
1166:ectoderm
1162:epiblast
1121:p38 MAPK
1117:p38 MAPK
1109:p38 MAPK
1101:p38 MAPK
1045:endoderm
973:Wikidata
658:Sources:
459:testicle
431:placenta
381:placenta
377:testicle
2321:3214085
2206:3262995
2114:9528758
2062:1821852
2018:1691726
1969:2761279
1920:3049358
1741:2864743
1718:Bibcode
1670:9239873
1621:2511439
1552:4404796
1524:Bibcode
1418:Ensembl
1397:Ensembl
1246:meiosis
1208:during
1144:During
1092:adipose
1065:protein
791:UniProt
746:Ensembl
685:Species
664:QuickGO
639:meiosis
593:nucleus
314:pattern
40:Aliases
2328:
2318:
2285:
2277:
2241:
2233:
2204:
2196:
2161:
2153:
2112:
2105:121416
2102:
2060:
2025:
2015:
1976:
1966:
1927:
1917:
1875:
1867:
1832:
1824:
1789:
1748:
1738:
1668:
1660:
1619:
1612:363733
1609:
1550:
1542:
1516:Nature
1499:
1369:Oct3/4
1365:Oct3/4
1361:Oct3/4
1357:Oct3/4
1353:Oct3/4
1349:Oct3/4
1344:Oct3/4
1214:allele
1190:Nespas
1158:Oct3/4
1148:, the
1029:murine
959:search
957:PubMed
824:P22227
805:Q96MM3
715:132625
701:Entrez
485:BioGPS
447:embryo
443:embryo
439:ureter
427:morula
172:4q35.2
64:614572
2283:S2CID
2255:(PDF)
2239:S2CID
2202:S2CID
2159:S2CID
1873:S2CID
1830:S2CID
1666:S2CID
1548:S2CID
1338:Nanog
1322:STAT3
1316:STAT3
1310:NOTCH
1304:NOTCH
1294:Rex-1
1290:Nanog
1286:Rex-1
1278:Nanog
1270:Rex-1
1266:Nanog
1260:Nanog
1129:STAT3
1125:NOTCH
1069:ZFP42
734:22702
694:Mouse
689:Human
660:Amigo
373:sperm
365:gonad
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:ZFP42
72:99187
47:ZFP42
24:ZFP42
2326:PMID
2275:PMID
2231:PMID
2194:PMID
2151:PMID
2110:PMID
2058:PMID
2023:PMID
1974:PMID
1925:PMID
1865:PMID
1822:PMID
1787:PMID
1746:PMID
1658:PMID
1617:PMID
1540:PMID
1497:PMID
1336:and
1334:Sox2
1328:Sox2
1274:Rex1
1264:The
1222:PEG3
1218:PEG3
1206:PEG3
1188:and
1186:PEG3
1127:and
1113:MKK3
1105:MKK3
1072:gene
1053:mRNA
1001:Rex1
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:7601
60:OMIM
2316:PMC
2308:doi
2304:356
2267:doi
2263:101
2223:doi
2184:doi
2143:doi
2100:PMC
2092:doi
2050:doi
2046:113
2013:PMC
2005:doi
2001:271
1964:PMC
1956:doi
1915:PMC
1907:doi
1857:doi
1853:135
1814:doi
1777:doi
1736:PMC
1726:doi
1648:doi
1607:PMC
1599:doi
1532:doi
1520:444
1487:doi
1483:281
1280:in
1198:YY1
290:End
189:End
92:OMA
68:MGI
2344::
2324:.
2314:.
2302:.
2298:.
2281:.
2273:.
2261:.
2257:.
2237:.
2229:.
2219:45
2217:.
2200:.
2192:.
2180:23
2178:.
2174:.
2157:.
2149:.
2139:22
2137:.
2108:.
2098:.
2088:18
2086:.
2082:.
2070:^
2056:.
2044:.
2021:.
2011:.
1999:.
1995:.
1972:.
1962:.
1952:37
1950:.
1946:.
1923:.
1913:.
1903:20
1901:.
1897:.
1885:^
1871:.
1863:.
1851:.
1828:.
1820:.
1810:24
1808:.
1785:.
1771:.
1767:.
1744:.
1734:.
1724:.
1712:.
1708:.
1692:^
1664:.
1656:.
1644:20
1642:.
1638:.
1615:.
1605:.
1593:.
1589:.
1577:^
1560:^
1546:.
1538:.
1530:.
1518:.
1495:.
1481:.
1477:.
1461:^
1451:.
1433:.
1404:^
1383:^
1340:.
1300:.
662:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2332:.
2310::
2289:.
2269::
2245:.
2225::
2208:.
2186::
2165:.
2145::
2116:.
2094::
2064:.
2052::
2029:.
2007::
1980:.
1958::
1931:.
1909::
1879:.
1859::
1836:.
1816::
1793:.
1779::
1773:7
1752:.
1728::
1720::
1714:5
1686:.
1672:.
1650::
1623:.
1601::
1595:9
1571:.
1554:.
1534::
1526::
1503:.
1489::
1455:.
1437:.
214:)
111:)
94::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
