785:
244:
33:
304:, thereby inactivating its actin-depolymerization activity. This results in the stabilization of actin filaments and an increase in their numbers. Thus, over time actin monomers that are needed to continue actin polymerization for migration become limited. The increased stable actin filaments and the loss of actin monomers contribute to a reduction of cell migration.
728:
ROCK activity is regulated by the disruption of an intramolecular autoinhibition. In general, the structure of ROCK proteins consists of an N-terminal kinase domain, a coiled-coiled region and a PH domain containing a cystein-rich domain (CRD) at the C-terminal. A Rho-binding domain (RBD) is located
740:
to the N-terminal kinase domain of ROCK. Thus, the kinase activity is off when ROCK is intramolecularly folded. The kinase activity is switched on when Rho-GTP binds to the Rho-binding domain of ROCK, disrupting the autoinhibitory interaction within ROCK, which liberates the kinase domain because
422:
ROCKs regulate cell-cell adhesion: Loss of ROCK activity seems to lead to loss of tight junction integrity in endothelial cells. In epithelial cells inhibition of ROCK seems to decrease tight junction integrity. Active ROCK in these cells seems to stimulate the disruption of E-Cadherin-mediated
234:
and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells.
407:. The pro-apoptotic protease, caspase 3, activates ROCK kinase activity by cleaving the C-terminal PH domain. As a result, the autoinhibitory intramolecular fold of ROCK is abolished. ROCK also regulates MLC phosphorylation and actomyosin contractility, which regulate membrane blebbing.
1301:
Gao SY, Li CY, Chen J, Pan L, Saito S, Terashita T, Saito K, Miyawaki K, Shigemoto K, Mominoki K, Matsuda S, Kobayashi N (2004). "Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted process elongation".
439:
F-actin binding proteins: Adducin, EF-1&alpha (elongation factor, translation co-factor), MARCKS (myristylated alanine-rich C kinase substrate), Caponin (unknown function), and ERM (involved in linkage of the actin cytoskelton to the plasma
418:
collapse by activating actomyosin contractility. It is also possible that phosphorylation of collapsin response mediator protein-2 (CRMP2) by ROCK inhibits CRPM2 function of promoting axon outgrowth, resulting in growth cone
4721:
5748:
2673:
1159:
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (August 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase".
2865:
854:
for treating various diseases including cancer. For example, such drugs have potential to prevent cancer from spreading by blocking cell migration, stopping cancer cells from spreading into neighboring tissue.
3150:
336:
activity. Thus several bundled and active myosins, which are asynchronously active on several actin filaments, move actin filaments against each other, resulting in the net shortenting of actin fibres.
1786:
Kale, Vijay
Pralhad; Hengst, Jeremy A.; Desai, Dhimant H.; Dick, Taryn E.; Choe, Katherine N.; Colledge, Ashley L.; Takahashi, Yoshinori; Sung, Shen-Shu; Amin, Shantu G.; Yun, Jong K. (2014-11-28).
839:. ROCK1/2 along with MRCKα/β kinases have been implicated in the plasticity of cancer cell migration, the phenomenon which bestows survival advantage to the cancer cells during drug treatments (
4714:
2683:
2678:
2858:
4707:
5622:
2851:
2798:
2776:
3058:
2594:
378:
suppressor protein. This stimulation seems to depend on ROCK. In this way, PTEN is important to prevent uncontrolled cell division as is exhibited in cancer cells.
353:, actin filament bundles of opposing polarity, containing myosin II, tropomyosin, caldesmon and MLC-kinase, and consequently of focal contacts, which are immature
4730:
587:
472:
64:
3606:
4445:
2909:
4554:
2704:
1445:"Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments"
1396:"Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow"
704:)-binding kinases (MRCK) and citron kinase. All of these kinases are composed of a N-terminal kinase domain, a coiled-coil structure and other functional
3292:
3179:
4773:
3567:
5218:
2599:
5725:
5361:
5269:
5166:
4540:
4005:
2896:
2878:
2766:
106:
4880:
4836:
5683:
4642:
4523:
1244:
Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D (April 2005). "Regulation of PTEN by Rho small GTPases".
4763:
4229:
3098:
4293:
3268:
2405:
5662:
5585:
4549:
3083:
611:
496:
5705:
4606:
4281:
2539:
5114:
3538:
3528:
3213:
2109:
1903:
1647:
Chong CM, Ai N, Lee SM (2017). "ROCK in CNS: Different Roles of
Isoforms and Therapeutic Target for Neurodegenerative Disorders".
5244:
4220:
2250:
1287:
1017:"The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton"
599:
484:
5617:
69:
4489:
4161:
3523:
3514:
1494:"Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo"
592:
477:
5673:
4875:
4851:
4831:
165:(PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present.
5480:
4885:
3904:
3401:
3392:
3049:
2995:
2823:
2818:
2378:
2196:
828:
251:
ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small
5638:
5613:
5604:
5466:
5119:
3092:
2688:
2576:
2544:
2529:
385:
in G1, and is proposed to be required for contraction of the cleavage furrow, which is necessary for the completion of
4746:
2211:
5497:
2843:
815:
Research over the past two decades has shown that ROCK signaling plays an important role in many diseases including
4116:
3934:
3430:
1843:
Feng Y, LoGrasso PV, Defert O, Li R (March 2016). "Rho Kinase (ROCK) Inhibitors and Their
Therapeutic Potential".
5778:
4106:
4101:
4096:
4086:
4081:
4076:
4066:
3861:
3636:
3232:
2809:
2787:
2762:
2737:
2657:
2265:
2225:
2170:
2147:
2119:
2087:
1953:
436:
intermediate filament proteins: Vimentin, GFAP (glial fibrillaric acidic protein), NF-L (neurofilament L protein)
2040:
1788:"A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion"
1069:"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice"
5720:
5307:
4810:
4792:
4329:
4320:
4271:
3037:
2882:
2274:
2255:
2186:
1920:
81:
1584:"Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening"
286:. These substrates, once phosphorylated, regulate actin filament organization and contractility as follows:
5513:
5223:
5193:
5178:
5141:
4629:
4052:
2132:
697:
381:
ROCK plays an important role in cell cycle control, it seems to inhibit the premature separation of the two
4801:
2586:
2359:
2269:
824:
820:
816:
604:
489:
132:
5594:
5405:
5173:
3328:
2440:
2395:
2097:
2082:
2018:
1998:
1896:
717:
255:
1739:
Kale, Vijay
Pralhad; Hengst, Jeremy A.; Desai, Dhimant H.; Amin, Shantu G.; Yun, Jong K. (2015-06-01).
1881:
4997:
3895:
2354:
2349:
2229:
2092:
2072:
1981:
1740:
847:
770:
750:
733:
296:
ROCK inhibits the depolymerization of actin filaments indirectly: ROCK phosphorylates and activates
5768:
5576:
5449:
2617:
2609:
2390:
2057:
1993:
1957:
162:
4403:
1443:
Yasui Y, Amano M, Nagata K, Inagaki N, Nakamura H, Saya H, Kaibuchi K, Inagaki M (November 1998).
5773:
4982:
4947:
4506:
4460:
2480:
2418:
2369:
2104:
1931:
1629:
1425:
1376:
1327:
1269:
1197:"ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells"
1141:
1098:
997:
929:
686:
4699:
4870:
4826:
3766:
3475:
2495:
2485:
2475:
2400:
2384:
2343:
2329:
2324:
2062:
2025:
1868:
1860:
1825:
1807:
1768:
1760:
1721:
1672:
1664:
1621:
1603:
1564:
1515:
1474:
1417:
1368:
1319:
1261:
1226:
1177:
1133:
1090:
1046:
989:
921:
400:
4841:
4819:
4815:
4359:
3601:
3591:
3586:
3504:
3495:
3425:
3416:
3362:
3353:
3010:
2828:
2490:
2470:
2412:
2308:
2206:
2191:
2137:
2035:
2030:
1889:
1852:
1815:
1799:
1752:
1711:
1703:
1656:
1611:
1595:
1554:
1546:
1505:
1464:
1456:
1407:
1358:
1311:
1253:
1216:
1208:
1169:
1125:
1080:
1036:
1028:
981:
911:
903:
754:
231:
147:
5538:
5079:
1288:"Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1)"
86:
5561:
5556:
5317:
5312:
5288:
5283:
5249:
5146:
5074:
4898:
4185:
3256:
3251:
3246:
2751:
2741:
2563:
2534:
2160:
2067:
2052:
1741:"The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration"
840:
758:
659:
544:
181:
173:
168:
Rat ROCKs were discovered as the first effectors of Rho and they induce the formation of
916:
891:
5260:
2719:
2558:
2465:
2457:
2334:
2297:
1820:
1787:
1716:
1691:
1616:
1583:
1559:
1534:
1469:
1444:
1221:
1196:
705:
315:
267:
143:
109:. It is involved mainly in regulating the shape and movement of cells by acting on the
1660:
1363:
1346:
1041:
1016:
784:
433:
NHE1 (a sodium hydrogen exchanger, involved in focal adhesions and actin organisation)
243:
5762:
5339:
5278:
5151:
3309:
3241:
1988:
1633:
1394:
Kosako H, Yoshida T, Matsumura F, Ishizaki T, Narumiya S, Inagaki M (December 2000).
1085:
1068:
972:
Riento K, Ridley AJ (June 2003). "Rocks: multifunctional kinases in cell behaviour".
193:
1429:
1380:
1331:
1273:
1145:
1116:
Anjum I (June 2018). "Calcium sensitization mechanisms in detrusor smooth muscles".
1001:
318:
and thus cell-substratum contacts. ROCK increases the activity of the motor protein
5295:
5133:
4180:
3005:
2077:
2047:
1976:
1102:
933:
892:"Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity"
350:
259:
169:
110:
1599:
1550:
1212:
1195:
Wang Y, Zheng XR, Riddick N, Bryden M, Baur W, Zhang X, Surks HK (February 2009).
696:
ROCKs are homologous to other metazoan kinases such as myotonic dystrophy kinase (
1856:
1803:
1756:
1173:
628:
513:
396:
signaling pathway, resulting in a reduction of cell size and influence cell fate.
5198:
4768:
4386:
4018:
3958:
3841:
3761:
3485:
2643:
2633:
2234:
1971:
1912:
1067:
Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S (August 1996).
669:
554:
415:
386:
371:
367:
340:
283:
158:
5388:
5183:
4860:
4474:
2948:
2445:
2288:
2201:
1966:
1916:
1707:
907:
690:
635:
520:
382:
297:
138:
5710:
1864:
1811:
1764:
1668:
1607:
5652:
4865:
4783:
3435:
2724:
2637:
2174:
1940:
1510:
1493:
1129:
737:
404:
189:
32:
1872:
1829:
1772:
1725:
1676:
1625:
1568:
1519:
1460:
1421:
1412:
1395:
1323:
1265:
1230:
1181:
1137:
1032:
993:
925:
835:. For example, ROCK has been hypothesized to play an important role in the
1478:
1372:
1094:
1050:
349:
Thus in both cases, ROCK activation by Rho induces the formation of actin
3791:
3686:
3681:
3676:
2571:
2151:
851:
640:
525:
354:
266:
1. ROCK is a key regulator of actin organization and thus a regulator of
5730:
5454:
5300:
4450:
4428:
4423:
4413:
4408:
4210:
4205:
4200:
4195:
4190:
4175:
4170:
3821:
3786:
3025:
3020:
3015:
2522:
2507:
2123:
1347:"A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos"
411:
393:
301:
126:
17:
1315:
5735:
5523:
5518:
5228:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4601:
4596:
4591:
4586:
4581:
4564:
4559:
4433:
4418:
4369:
4364:
4349:
4344:
4339:
4334:
4308:
4303:
4298:
4286:
4264:
4259:
4151:
4126:
3801:
3626:
3621:
3616:
3611:
3596:
3440:
3377:
3372:
3367:
3343:
3169:
3164:
3138:
3133:
3128:
3118:
3113:
3103:
2943:
2874:
2500:
1935:
836:
832:
623:
508:
333:
329:
319:
279:
275:
252:
217:
213:
209:
177:
151:
102:
1257:
985:
274:
Different substrates can be phosphorylated by ROCKs, including LIM
5533:
5528:
5490:
5475:
5442:
5437:
5398:
5393:
5381:
5376:
5371:
5366:
5354:
5332:
5327:
5322:
5099:
5094:
5089:
5084:
5044:
5039:
4977:
4972:
4967:
4962:
4937:
4932:
4927:
4922:
4917:
4912:
4907:
4576:
4569:
4479:
4376:
4276:
4254:
4249:
4244:
4239:
4234:
4146:
4141:
4136:
4131:
4121:
4091:
4071:
3948:
3943:
3924:
3919:
3909:
3885:
3880:
3875:
3851:
3846:
3836:
3831:
3826:
3816:
3796:
3781:
3776:
3771:
3751:
3746:
3736:
3731:
3726:
3721:
3716:
3706:
3701:
3696:
3691:
3671:
3666:
3661:
3656:
3651:
3646:
3631:
3581:
3576:
3470:
3465:
3460:
3455:
3450:
3445:
3406:
3338:
3333:
3282:
3277:
3203:
3198:
3193:
3159:
3151:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2953:
2938:
2933:
2928:
2923:
2918:
2517:
2512:
2364:
864:
701:
693:
sequences in common and 92% homology within their kinase domains.
682:
465:
375:
225:
221:
205:
197:
185:
121:
117:
2674:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
200:
and ROCK2 have been identified. ROCK1 is mainly expressed in the
5715:
5700:
5485:
5425:
5420:
5415:
5410:
5349:
5344:
5188:
5161:
5156:
5069:
5064:
5059:
5054:
5049:
5026:
5021:
5016:
5011:
5006:
4957:
4952:
4942:
4469:
4396:
4391:
4381:
4354:
4111:
4061:
4042:
4037:
4032:
4027:
3982:
3977:
3972:
3967:
3914:
3870:
3811:
3806:
3756:
3741:
3711:
3641:
3557:
3552:
3547:
3480:
3382:
3323:
3318:
3222:
3188:
3073:
3068:
3063:
3032:
3000:
2988:
2983:
2978:
2968:
2963:
2428:
2423:
2319:
2314:
2013:
2008:
2003:
1690:
Wei L, Surma M, Shi S, Lambert-Cheatham N, Shi J (August 2016).
616:
501:
201:
154:
4703:
4627:
4003:
2894:
2847:
1885:
4438:
2973:
2958:
779:
753:
of ROCK. ROCK can also be regulated by lipids, in particular
736:
binding between the C-terminal cluster of RBD domain and the
5749:
deficiencies of intracellular signaling peptides and proteins
366:
RhoA-GTP stimulates the phospholipid phosphatase activity of
720:
Rho that increases ROCK kinase activity when bound to it.
423:
cell-cell contacts by activating actomyosin contractility.
1345:
Drechsel DN, Hyman AA, Hall A, Glotzer M (January 1997).
1118:
Journal of Basic and
Clinical Physiology and Pharmacology
357:-based adhesion points with the extracellular substrate.
314:
ROCK also regulates cell migration by promoting cellular
124:) occur in mammals (human, rat, mouse, cow), zebrafish,
1692:"Novel Insights into the Roles of Rho Kinase in Cancer"
796:
569:
Rho-associated, coiled-coil-containing protein kinase 2
452:
Rho-associated, coiled-coil-containing protein kinase 1
1582:
Yu B, Sladojevic N, Blair JE, Liao JK (January 2020).
2684:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
59:
Rho-associated, coiled-coil-containing protein kinase
2689:
CDP-diacylglycerol—choline O-phosphatidyltransferase
403:, a morphological change seen in cells committed to
343:, leading to increased levels of phosphorylated MLC.
328:
Firstly, phosphorylation of the myosin light chain (
5693:
5672:
5651:
5631:
5603:
5584:
5574:
5549:
5506:
5465:
5268:
5258:
5237:
5211:
5132:
4850:
4800:
4791:
4782:
4756:
4737:
4641:
4539:
4522:
4505:
4488:
4459:
4319:
4219:
4160:
4051:
4017:
3957:
3933:
3894:
3860:
3566:
3537:
3513:
3494:
3415:
3391:
3352:
3308:
3291:
3267:
3231:
3212:
3178:
3149:
3082:
3048:
2908:
2808:
2786:
2761:
2736:
2717:
2697:
2679:
CDP-diacylglycerol—serine O-phosphatidyltransferase
2666:
2656:
2626:
2608:
2585:
2557:
2456:
2296:
2287:
2264:
2224:
2169:
2146:
2118:
1952:
1928:
729:in close proximity just in front of the PH domain.
665:
655:
650:
634:
622:
610:
598:
586:
578:
573:
568:
550:
540:
535:
519:
507:
495:
483:
471:
461:
456:
451:
80:
75:
63:
55:
47:
42:
25:
5623:Sh2 domain-containing protein tyrosine phosphatase
1535:"ROCK as a therapeutic target for ischemic stroke"
1015:Leung T, Chen XQ, Manser E, Lim L (October 1996).
700:), DMPK-related cell division control protein 42 (
1696:Archivum Immunologiae et Therapiae Experimentalis
761:, which induces N-terminal transphosphorylation.
749:It has also been shown that Rho is not the only
741:ROCK is then no longer intramolecularly folded.
157:. Mammalian ROCK consists of a kinase domain, a
150:and is a major downstream effector of the small
967:
965:
963:
961:
959:
957:
955:
953:
951:
949:
947:
945:
943:
885:
883:
881:
879:
716:ROCK is a downstream effector molecule of the
258:, which is one of the major regulators of the
220:. However, ROCK2 is distributed mostly in the
105:belonging to the AGC (PKA/ PKG/PKC) family of
4731:Intracellular signaling peptides and proteins
4715:
2910:Non-specific serine/threonine protein kinases
2859:
1897:
1533:Sladojevic N, Yu B, Liao JK (December 2017).
1062:
1060:
8:
2705:N-acetylglucosamine-1-phosphate transferase
2595:UTP—glucose-1-phosphate uridylyltransferase
5618:Receptor-like protein tyrosine phosphatase
5581:
5265:
4797:
4788:
4722:
4708:
4700:
4638:
4624:
4014:
4000:
3293:Goodpasture-antigen-binding protein kinase
2905:
2891:
2866:
2852:
2844:
2733:
2663:
2293:
2284:
1949:
1904:
1890:
1882:
647:
532:
31:
5219:Cyclin-dependent kinase inhibitor protein
4006:Serine/threonine-specific protein kinases
3180:(isocitrate dehydrogenase (NADP+)) kinase
2897:Serine/threonine-specific protein kinases
2879:Serine/threonine-specific protein kinases
2799:serine/threonine-specific protein kinases
2777:serine/threonine-specific protein kinases
2600:Galactose-1-phosphate uridylyltransferase
1819:
1715:
1615:
1558:
1509:
1468:
1411:
1362:
1220:
1084:
1040:
915:
107:serine-threonine specific protein kinases
5726:Phosphatidylethanolamine binding protein
5362:Interleukin-1 receptor associated kinase
4774:Ca2+/calmodulin-dependent protein kinase
4541:Receptor protein serine/threonine kinase
732:The kinase activity is inhibited by the
242:
4524:Low-density-lipoprotein receptor kinase
890:Hahmann C, Schroeter T (January 2010).
875:
5481:Focal adhesion protein-tyrosine kinase
4764:Intracellular calcium-sensing proteins
974:Nature Reviews. Molecular Cell Biology
565:
448:
22:
3269:Fas-activated serine/threonine kinase
1588:Expert Opinion on Therapeutic Targets
819:, neurodegenerative diseases such as
7:
4550:Bone morphogenetic protein receptors
896:Cellular and Molecular Life Sciences
3084:Dephospho-(reductase kinase) kinase
196:increases. Two mouse ROCK isoforms
5706:Signal transducing adaptor protein
4881:3',5'-cyclic-GMP phosphodiesterase
4837:3',5'-cyclic-AMP phosphodiesterase
3539:G-protein coupled receptor kinases
1539:Expert Review of Neurotherapeutics
392:ROCKs also seem to antagonize the
180:(myosin light chain). Due to this
14:
5701:Activating transcription factor 6
5115:G protein-coupled receptor kinase
3529:Beta adrenergic receptor kinase-2
3214:(tyrosine 3-monooxygenase) kinase
2110:Glucose-1,6-bisphosphate synthase
1661:10.2174/1389450117666160401123825
1492:Piekny AJ, Mains PE (June 2002).
142:) and chicken. Human ROCK1 has a
37:Crystal structure of human ROCK I
5245:Phosphoinositide phospholipase C
4221:Mitogen-activated protein kinase
2251:Ribose-phosphate diphosphokinase
783:
322:II by two different mechanisms:
4607:Anti-Müllerian hormone receptor
4490:(acetyl-CoA carboxylase) kinase
4162:(RNA-polymerase)-subunit kinase
3524:Beta adrenergic receptor kinase
3515:Beta adrenergic receptor kinase
1304:Nephron Experimental Nephrology
374:and tensin homologue), a human
339:Secondly, ROCK inactivates MLC
300:, which in turn phosphorylates
5684:GTP-binding protein regulators
5674:GTP-binding protein regulators
4230:Extracellular signal-regulated
1845:Journal of Medicinal Chemistry
1021:Molecular and Cellular Biology
837:pleiotropic effects of statins
361:2. Other functions and targets
1:
5433:Rho-associated protein kinase
4294:P38 mitogen-activated protein
3393:cGMP-dependent protein kinase
3354:cAMP-dependent protein kinase
3050:Pyruvate dehydrogenase kinase
2996:Ataxia telangiectasia mutated
2824:Protein-histidine tele-kinase
2819:Protein-histidine pros-kinase
2698:Glycosyl-1-phosphotransferase
1600:10.1080/14728222.2020.1712593
1551:10.1080/14737175.2017.1395700
1364:10.1016/S0960-9822(06)00023-6
1213:10.1161/CIRCRESAHA.108.188524
829:amyotrophic lateral sclerosis
681:The two mouse ROCK isoforms,
95:Rho-associated protein kinase
51:Rho-associated protein kinase
5639:Dual-specificity phosphatase
5614:protein tyrosine phosphatase
5120:AMP-activated protein kinase
3093:AMP-activated protein kinase
2530:RNA-dependent RNA polymerase
1857:10.1021/acs.jmedchem.5b00683
1804:10.1016/j.canlet.2014.08.032
1757:10.1016/j.canlet.2015.03.017
1174:10.1126/science.285.5429.895
1086:10.1016/0014-5793(96)00811-3
5663:apoptosis signaling pathway
4008:(EC 2.7.11.21-EC 2.7.11.30)
2437:RNA-directed DNA polymerase
2305:DNA-directed DNA polymerase
1449:The Journal of Cell Biology
846:Researchers are developing
247:Role and regulation of ROCK
5795:
3935:Elongation factor 2 kinase
2899:(EC 2.7.11.1-EC 2.7.11.20)
2790:: protein-dual-specificity
768:
332:) increases the myosin II
282:light chain (MLC) and MLC
15:
5744:
5507:Serine/threonine/tyrosine
5110:
4993:
4894:
4637:
4623:
4330:MAP kinase kinase kinases
4013:
3999:
3862:Myosin light-chain kinase
3568:Ca2+/calmodulin-dependent
3233:Myosin-heavy-chain kinase
2904:
2890:
1708:10.1007/s00005-015-0382-6
908:10.1007/s00018-009-0189-x
646:
531:
291:Amount of actin filaments
30:
5721:Olfactory marker protein
5308:Glycogen synthase kinase
4811:Heterotrimeric G protein
4630:Dual-specificity kinases
2767:protein-serine/threonine
2667:Phosphatidyltransferases
2256:Thiamine diphosphokinase
16:Not to be confused with
5514:Dual-specificity kinase
5224:Cyclin-dependent kinase
4053:Cyclin-dependent kinase
1511:10.1242/jcs.115.11.2271
1498:Journal of Cell Science
1130:10.1515/jbcpp-2017-0071
414:retraction by inducing
2587:Nucleotidyltransferase
2270:nucleotidyltransferase
2197:Nucleoside-diphosphate
1461:10.1083/jcb.143.5.1249
1413:10.1038/sj.onc.1203987
1033:10.1128/mcb.16.10.5313
817:cardiovascular disease
309:Cellular contractility
248:
5595:Protein phosphatase 2
5406:p21-activated kinases
2441:Reverse transcriptase
769:Further information:
685:and ROCK2, have high
428:3. Other ROCK targets
399:ROCKS play a role in
246:
4998:G beta-gamma complex
3896:Phosphorylase kinase
2230:diphosphotransferase
2212:Thiamine-diphosphate
1919:-containing groups (
1649:Current Drug Targets
1201:Circulation Research
771:Rho kinase inhibitor
410:ROCKs contribute to
5577:protein phosphatase
5450:Ribosomal s6 kinase
2812:: protein-histidine
2730:; protein acceptor)
2618:mRNA capping enzyme
2610:Guanylyltransferase
1246:Nature Cell Biology
825:Parkinson's disease
821:Alzheimer's disease
708:at the C-terminus
176:by phosphorylating
163:Pleckstrin homology
4747:MAP kinase pathway
4507:Tropomyosin kinase
4461:Tau-protein kinase
2088:Phosphoinositide 3
1932:phosphotransferase
1504:(Pt 11): 2271–82.
795:. You can help by
249:
5756:
5755:
5711:I-kappa B protein
5647:
5646:
5570:
5569:
5207:
5206:
5128:
5127:
4871:Guanylate cyclase
4827:Adenylate cyclase
4697:
4696:
4693:
4692:
4689:
4688:
4619:
4618:
4615:
4614:
3995:
3994:
3991:
3990:
3476:Protein kinase N1
3431:Protein kinase Cζ
2841:
2840:
2837:
2836:
2713:
2712:
2652:
2651:
2553:
2552:
2466:Template-directed
2220:
2219:
2187:Phosphomevalonate
1545:(12): 1167–1177.
1316:10.1159/000078406
813:
812:
679:
678:
675:
674:
564:
563:
560:
559:
401:membrane blebbing
130:, invertebrates (
92:
91:
5786:
5779:Protein families
5586:Serine/threonine
5582:
5270:Serine/threonine
5266:
4886:Protein kinase G
4842:Protein kinase A
4798:
4789:
4724:
4717:
4710:
4701:
4639:
4625:
4272:C-Jun N-terminal
4015:
4001:
3505:Rhodopsin kinase
3496:Rhodopsin kinase
3426:Protein kinase C
3417:Protein kinase C
3402:Protein kinase G
3363:Protein kinase A
2974:Protein kinase B
2906:
2892:
2868:
2861:
2854:
2845:
2829:Histidine kinase
2752:tyrosine kinases
2742:protein-tyrosine
2734:
2664:
2471:RNA polymerase I
2294:
2285:
2138:Aspartate kinase
2133:Phosphoglycerate
1950:
1906:
1899:
1892:
1883:
1877:
1876:
1851:(6): 2269–2300.
1840:
1834:
1833:
1823:
1783:
1777:
1776:
1736:
1730:
1729:
1719:
1687:
1681:
1680:
1644:
1638:
1637:
1619:
1579:
1573:
1572:
1562:
1530:
1524:
1523:
1513:
1489:
1483:
1482:
1472:
1440:
1434:
1433:
1415:
1391:
1385:
1384:
1366:
1342:
1336:
1335:
1298:
1292:
1291:
1284:
1278:
1277:
1241:
1235:
1234:
1224:
1192:
1186:
1185:
1156:
1150:
1149:
1113:
1107:
1106:
1088:
1064:
1055:
1054:
1044:
1012:
1006:
1005:
969:
938:
937:
919:
887:
808:
805:
787:
780:
755:arachidonic acid
745:Other regulators
689:. They have 65%
648:
566:
533:
449:
232:Protein kinase C
35:
23:
5794:
5793:
5789:
5788:
5787:
5785:
5784:
5783:
5759:
5758:
5757:
5752:
5740:
5689:
5668:
5643:
5627:
5599:
5566:
5557:Arginine kinase
5545:
5502:
5461:
5254:
5250:Phospholipase C
5233:
5203:
5124:
5106:
5036:
5003:
4989:
4904:
4899:G alpha subunit
4890:
4846:
4778:
4752:
4733:
4728:
4698:
4685:
4633:
4611:
4535:
4518:
4501:
4484:
4455:
4315:
4215:
4186:P70-S6 Kinase 1
4156:
4047:
4009:
3987:
3953:
3929:
3890:
3856:
3562:
3533:
3509:
3490:
3411:
3387:
3348:
3304:
3287:
3263:
3257:Aurora C kinase
3252:Aurora B kinase
3247:Aurora A kinase
3227:
3208:
3174:
3145:
3078:
3044:
2900:
2886:
2872:
2842:
2833:
2804:
2782:
2757:
2728:
2722:
2718:2.7.10-2.7.13:
2709:
2693:
2660:: miscellaneous
2648:
2622:
2604:
2581:
2564:exoribonuclease
2561:
2549:
2535:Polyadenylation
2452:
2278:
2272:
2260:
2242:
2238:
2232:
2216:
2178:
2165:
2142:
2114:
1944:
1938:
1930:
1924:
1910:
1880:
1842:
1841:
1837:
1785:
1784:
1780:
1738:
1737:
1733:
1689:
1688:
1684:
1646:
1645:
1641:
1581:
1580:
1576:
1532:
1531:
1527:
1491:
1490:
1486:
1442:
1441:
1437:
1406:(52): 6059–64.
1393:
1392:
1388:
1351:Current Biology
1344:
1343:
1339:
1300:
1299:
1295:
1286:
1285:
1281:
1258:10.1038/ncb1236
1243:
1242:
1238:
1194:
1193:
1189:
1168:(5429): 895–8.
1158:
1157:
1153:
1115:
1114:
1110:
1066:
1065:
1058:
1027:(10): 5313–27.
1014:
1013:
1009:
986:10.1038/nrm1128
971:
970:
941:
889:
888:
877:
873:
861:
848:ROCK inhibitors
841:drug resistance
809:
803:
800:
793:needs expansion
778:
773:
767:
759:oligomerization
714:
447:
241:
192:and, thus, the
182:phosphorylation
174:focal adhesions
38:
21:
12:
11:
5:
5792:
5790:
5782:
5781:
5776:
5771:
5761:
5760:
5754:
5753:
5745:
5742:
5741:
5739:
5738:
5733:
5728:
5723:
5718:
5713:
5708:
5703:
5697:
5695:
5691:
5690:
5688:
5687:
5678:
5676:
5670:
5669:
5667:
5666:
5657:
5655:
5649:
5648:
5645:
5644:
5642:
5641:
5635:
5633:
5629:
5628:
5626:
5625:
5620:
5610:
5608:
5601:
5600:
5598:
5597:
5591:
5589:
5579:
5572:
5571:
5568:
5567:
5565:
5564:
5559:
5553:
5551:
5547:
5546:
5544:
5543:
5542:
5541:
5536:
5531:
5526:
5521:
5510:
5508:
5504:
5503:
5501:
5500:
5495:
5494:
5493:
5488:
5478:
5472:
5470:
5463:
5462:
5460:
5459:
5458:
5457:
5447:
5446:
5445:
5440:
5430:
5429:
5428:
5423:
5418:
5413:
5403:
5402:
5401:
5396:
5386:
5385:
5384:
5379:
5374:
5369:
5359:
5358:
5357:
5352:
5347:
5337:
5336:
5335:
5330:
5325:
5320:
5315:
5305:
5304:
5303:
5293:
5292:
5291:
5286:
5275:
5273:
5263:
5261:protein kinase
5256:
5255:
5253:
5252:
5247:
5241:
5239:
5235:
5234:
5232:
5231:
5226:
5221:
5215:
5213:
5209:
5208:
5205:
5204:
5202:
5201:
5196:
5191:
5186:
5181:
5176:
5171:
5170:
5169:
5164:
5159:
5149:
5144:
5138:
5136:
5130:
5129:
5126:
5125:
5123:
5122:
5117:
5111:
5108:
5107:
5105:
5104:
5103:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5047:
5042:
5034:
5031:
5030:
5029:
5024:
5019:
5014:
5009:
5001:
4994:
4991:
4990:
4988:
4987:
4986:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4920:
4915:
4910:
4902:
4895:
4892:
4891:
4889:
4888:
4883:
4878:
4873:
4868:
4863:
4857:
4855:
4848:
4847:
4845:
4844:
4839:
4834:
4829:
4824:
4823:
4822:
4807:
4805:
4795:
4793:Heterotrimeric
4786:
4780:
4779:
4777:
4776:
4771:
4766:
4760:
4758:
4754:
4753:
4751:
4750:
4741:
4739:
4735:
4734:
4729:
4727:
4726:
4719:
4712:
4704:
4695:
4694:
4691:
4690:
4687:
4686:
4684:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4647:
4645:
4635:
4634:
4628:
4621:
4620:
4617:
4616:
4613:
4612:
4610:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4574:
4573:
4572:
4567:
4562:
4557:
4546:
4544:
4543:(EC 2.7.11.30)
4537:
4536:
4534:
4533:
4529:
4527:
4526:(EC 2.7.11.29)
4520:
4519:
4517:
4516:
4512:
4510:
4509:(EC 2.7.11.28)
4503:
4502:
4500:
4499:
4495:
4493:
4492:(EC 2.7.11.27)
4486:
4485:
4483:
4482:
4477:
4472:
4466:
4464:
4463:(EC 2.7.11.26)
4457:
4456:
4454:
4453:
4448:
4443:
4442:
4441:
4436:
4431:
4426:
4421:
4416:
4411:
4401:
4400:
4399:
4394:
4389:
4384:
4374:
4373:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4326:
4324:
4323:(EC 2.7.11.25)
4317:
4316:
4314:
4313:
4312:
4311:
4306:
4301:
4291:
4290:
4289:
4284:
4279:
4269:
4268:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4226:
4224:
4223:(EC 2.7.11.24)
4217:
4216:
4214:
4213:
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4167:
4165:
4164:(EC 2.7.11.23)
4158:
4157:
4155:
4154:
4149:
4144:
4139:
4134:
4129:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4058:
4056:
4055:(EC 2.7.11.22)
4049:
4048:
4046:
4045:
4040:
4035:
4030:
4024:
4022:
4021:(EC 2.7.11.21)
4011:
4010:
4004:
3997:
3996:
3993:
3992:
3989:
3988:
3986:
3985:
3980:
3975:
3970:
3964:
3962:
3961:(EC 2.7.11.21)
3955:
3954:
3952:
3951:
3946:
3940:
3938:
3937:(EC 2.7.11.20)
3931:
3930:
3928:
3927:
3922:
3917:
3912:
3907:
3901:
3899:
3898:(EC 2.7.11.19)
3892:
3891:
3889:
3888:
3883:
3878:
3873:
3867:
3865:
3864:(EC 2.7.11.18)
3858:
3857:
3855:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3649:
3644:
3639:
3634:
3629:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3589:
3584:
3579:
3573:
3571:
3570:(EC 2.7.11.17)
3564:
3563:
3561:
3560:
3555:
3550:
3544:
3542:
3541:(EC 2.7.11.16)
3535:
3534:
3532:
3531:
3526:
3520:
3518:
3517:(EC 2.7.11.15)
3511:
3510:
3508:
3507:
3501:
3499:
3498:(EC 2.7.11.14)
3492:
3491:
3489:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3448:
3443:
3438:
3433:
3428:
3422:
3420:
3419:(EC 2.7.11.13)
3413:
3412:
3410:
3409:
3404:
3398:
3396:
3395:(EC 2.7.11.12)
3389:
3388:
3386:
3385:
3380:
3375:
3370:
3365:
3359:
3357:
3356:(EC 2.7.11.11)
3350:
3349:
3347:
3346:
3341:
3336:
3331:
3326:
3321:
3315:
3313:
3312:(EC 2.7.11.10)
3306:
3305:
3303:
3302:
3298:
3296:
3289:
3288:
3286:
3285:
3280:
3274:
3272:
3265:
3264:
3262:
3261:
3260:
3259:
3254:
3249:
3238:
3236:
3229:
3228:
3226:
3225:
3219:
3217:
3210:
3209:
3207:
3206:
3201:
3196:
3191:
3185:
3183:
3176:
3175:
3173:
3172:
3167:
3162:
3156:
3154:
3147:
3146:
3144:
3143:
3142:
3141:
3136:
3131:
3123:
3122:
3121:
3116:
3108:
3107:
3106:
3101:
3089:
3087:
3080:
3079:
3077:
3076:
3071:
3066:
3061:
3055:
3053:
3046:
3045:
3043:
3042:
3041:
3040:
3030:
3029:
3028:
3023:
3018:
3013:
3003:
2998:
2993:
2992:
2991:
2986:
2981:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2915:
2913:
2902:
2901:
2895:
2888:
2887:
2873:
2871:
2870:
2863:
2856:
2848:
2839:
2838:
2835:
2834:
2832:
2831:
2826:
2821:
2815:
2813:
2806:
2805:
2803:
2802:
2793:
2791:
2784:
2783:
2781:
2780:
2771:
2769:
2759:
2758:
2756:
2755:
2746:
2744:
2731:
2726:
2720:protein kinase
2715:
2714:
2711:
2710:
2708:
2707:
2701:
2699:
2695:
2694:
2692:
2691:
2686:
2681:
2676:
2670:
2668:
2661:
2654:
2653:
2650:
2649:
2647:
2646:
2641:
2630:
2628:
2624:
2623:
2621:
2620:
2614:
2612:
2606:
2605:
2603:
2602:
2597:
2591:
2589:
2583:
2582:
2580:
2579:
2574:
2568:
2566:
2559:Phosphorolytic
2555:
2554:
2551:
2550:
2548:
2547:
2542:
2537:
2532:
2527:
2526:
2525:
2520:
2515:
2505:
2504:
2503:
2493:
2488:
2483:
2478:
2473:
2468:
2462:
2460:
2458:RNA polymerase
2454:
2453:
2451:
2450:
2449:
2448:
2438:
2434:
2433:
2432:
2431:
2426:
2421:
2410:
2409:
2408:
2403:
2398:
2393:
2382:
2376:
2375:
2374:
2367:
2362:
2357:
2352:
2341:
2340:
2339:
2332:
2327:
2322:
2317:
2306:
2302:
2300:
2298:DNA polymerase
2291:
2282:
2276:
2262:
2261:
2259:
2258:
2253:
2247:
2245:
2240:
2236:
2222:
2221:
2218:
2217:
2215:
2214:
2209:
2204:
2199:
2194:
2189:
2183:
2181:
2176:
2167:
2166:
2164:
2163:
2157:
2155:
2144:
2143:
2141:
2140:
2135:
2129:
2127:
2116:
2115:
2113:
2112:
2107:
2102:
2101:
2100:
2095:
2085:
2083:Diacylglycerol
2080:
2075:
2070:
2065:
2060:
2055:
2050:
2045:
2044:
2043:
2033:
2028:
2023:
2022:
2021:
2016:
2011:
2006:
2001:
1994:Phosphofructo-
1991:
1986:
1985:
1984:
1974:
1969:
1963:
1961:
1947:
1942:
1926:
1925:
1911:
1909:
1908:
1901:
1894:
1886:
1879:
1878:
1835:
1798:(2): 299–310.
1792:Cancer Letters
1778:
1751:(2): 185–196.
1745:Cancer Letters
1731:
1682:
1655:(4): 455–462.
1639:
1574:
1525:
1484:
1455:(5): 1249–58.
1435:
1386:
1337:
1293:
1279:
1252:(4): 399–404.
1236:
1187:
1151:
1124:(3): 227–235.
1108:
1056:
1007:
939:
874:
872:
869:
868:
867:
860:
857:
811:
810:
790:
788:
777:
774:
766:
763:
757:, and protein
734:intramolecular
724:Autoinhibition
713:
710:
677:
676:
673:
672:
667:
663:
662:
657:
653:
652:
644:
643:
638:
632:
631:
626:
620:
619:
614:
608:
607:
602:
596:
595:
590:
584:
583:
580:
576:
575:
571:
570:
562:
561:
558:
557:
552:
548:
547:
542:
538:
537:
529:
528:
523:
517:
516:
511:
505:
504:
499:
493:
492:
487:
481:
480:
475:
469:
468:
463:
459:
458:
454:
453:
446:
443:
442:
441:
437:
434:
425:
424:
420:
408:
397:
390:
379:
347:
346:
345:
344:
337:
312:
311:
294:
293:
268:cell migration
240:
237:
144:molecular mass
90:
89:
84:
78:
77:
73:
72:
67:
61:
60:
57:
53:
52:
49:
45:
44:
40:
39:
36:
28:
27:
13:
10:
9:
6:
4:
3:
2:
5791:
5780:
5777:
5775:
5772:
5770:
5767:
5766:
5764:
5751:
5750:
5743:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5698:
5696:
5692:
5686:
5685:
5680:
5679:
5677:
5675:
5671:
5665:
5664:
5659:
5658:
5656:
5654:
5650:
5640:
5637:
5636:
5634:
5630:
5624:
5621:
5619:
5615:
5612:
5611:
5609:
5606:
5602:
5596:
5593:
5592:
5590:
5587:
5583:
5580:
5578:
5573:
5563:
5560:
5558:
5555:
5554:
5552:
5548:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5516:
5515:
5512:
5511:
5509:
5505:
5499:
5496:
5492:
5489:
5487:
5484:
5483:
5482:
5479:
5477:
5474:
5473:
5471:
5468:
5464:
5456:
5453:
5452:
5451:
5448:
5444:
5441:
5439:
5436:
5435:
5434:
5431:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5408:
5407:
5404:
5400:
5397:
5395:
5392:
5391:
5390:
5387:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5364:
5363:
5360:
5356:
5353:
5351:
5348:
5346:
5343:
5342:
5341:
5338:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5314:
5311:
5310:
5309:
5306:
5302:
5299:
5298:
5297:
5294:
5290:
5287:
5285:
5282:
5281:
5280:
5279:Casein kinase
5277:
5276:
5274:
5271:
5267:
5264:
5262:
5257:
5251:
5248:
5246:
5243:
5242:
5240:
5236:
5230:
5227:
5225:
5222:
5220:
5217:
5216:
5214:
5210:
5200:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5168:
5165:
5163:
5160:
5158:
5155:
5154:
5153:
5150:
5148:
5145:
5143:
5140:
5139:
5137:
5135:
5131:
5121:
5118:
5116:
5113:
5112:
5109:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5037:
5032:
5028:
5025:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5004:
4999:
4996:
4995:
4992:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4905:
4900:
4897:
4896:
4893:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4858:
4856:
4853:
4849:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4821:
4817:
4814:
4813:
4812:
4809:
4808:
4806:
4803:
4799:
4796:
4794:
4790:
4787:
4785:
4781:
4775:
4772:
4770:
4767:
4765:
4762:
4761:
4759:
4755:
4749:
4748:
4743:
4742:
4740:
4736:
4732:
4725:
4720:
4718:
4713:
4711:
4706:
4705:
4702:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4648:
4646:
4644:
4640:
4636:
4631:
4626:
4622:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4552:
4551:
4548:
4547:
4545:
4542:
4538:
4531:
4530:
4528:
4525:
4521:
4514:
4513:
4511:
4508:
4504:
4497:
4496:
4494:
4491:
4487:
4481:
4478:
4476:
4473:
4471:
4468:
4467:
4465:
4462:
4458:
4452:
4449:
4447:
4444:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4406:
4405:
4402:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4379:
4378:
4375:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4332:
4331:
4328:
4327:
4325:
4322:
4318:
4310:
4307:
4305:
4302:
4300:
4297:
4296:
4295:
4292:
4288:
4285:
4283:
4280:
4278:
4275:
4274:
4273:
4270:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4232:
4231:
4228:
4227:
4225:
4222:
4218:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4168:
4166:
4163:
4159:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4059:
4057:
4054:
4050:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4025:
4023:
4020:
4016:
4012:
4007:
4002:
3998:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3965:
3963:
3960:
3956:
3950:
3947:
3945:
3942:
3941:
3939:
3936:
3932:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3902:
3900:
3897:
3893:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3868:
3866:
3863:
3859:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3574:
3572:
3569:
3565:
3559:
3556:
3554:
3551:
3549:
3546:
3545:
3543:
3540:
3536:
3530:
3527:
3525:
3522:
3521:
3519:
3516:
3512:
3506:
3503:
3502:
3500:
3497:
3493:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3423:
3421:
3418:
3414:
3408:
3405:
3403:
3400:
3399:
3397:
3394:
3390:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3360:
3358:
3355:
3351:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3316:
3314:
3311:
3307:
3300:
3299:
3297:
3295:(EC 2.7.11.9)
3294:
3290:
3284:
3281:
3279:
3276:
3275:
3273:
3271:(EC 2.7.11.8)
3270:
3266:
3258:
3255:
3253:
3250:
3248:
3245:
3244:
3243:
3242:Aurora kinase
3240:
3239:
3237:
3235:(EC 2.7.11.7)
3234:
3230:
3224:
3221:
3220:
3218:
3216:(EC 2.7.11.6)
3215:
3211:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3186:
3184:
3182:(EC 2.7.11.5)
3181:
3177:
3171:
3168:
3166:
3163:
3161:
3158:
3157:
3155:
3153:(EC 2.7.11.4)
3152:
3148:
3140:
3137:
3135:
3132:
3130:
3127:
3126:
3124:
3120:
3117:
3115:
3112:
3111:
3109:
3105:
3102:
3100:
3097:
3096:
3094:
3091:
3090:
3088:
3086:(EC 2.7.11.3)
3085:
3081:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3056:
3054:
3052:(EC 2.7.11.2)
3051:
3047:
3039:
3036:
3035:
3034:
3031:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3008:
3007:
3006:EIF-2 kinases
3004:
3002:
2999:
2997:
2994:
2990:
2987:
2985:
2982:
2980:
2977:
2976:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2916:
2914:
2912:(EC 2.7.11.1)
2911:
2907:
2903:
2898:
2893:
2889:
2884:
2880:
2876:
2869:
2864:
2862:
2857:
2855:
2850:
2849:
2846:
2830:
2827:
2825:
2822:
2820:
2817:
2816:
2814:
2811:
2807:
2801:
2800:
2795:
2794:
2792:
2789:
2785:
2779:
2778:
2773:
2772:
2770:
2768:
2764:
2760:
2754:
2753:
2748:
2747:
2745:
2743:
2739:
2735:
2732:
2729:
2721:
2716:
2706:
2703:
2702:
2700:
2696:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2671:
2669:
2665:
2662:
2659:
2655:
2645:
2642:
2639:
2635:
2632:
2631:
2629:
2625:
2619:
2616:
2615:
2613:
2611:
2607:
2601:
2598:
2596:
2593:
2592:
2590:
2588:
2584:
2578:
2575:
2573:
2570:
2569:
2567:
2565:
2560:
2556:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2524:
2521:
2519:
2516:
2514:
2511:
2510:
2509:
2506:
2502:
2499:
2498:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2463:
2461:
2459:
2455:
2447:
2444:
2443:
2442:
2439:
2436:
2435:
2430:
2427:
2425:
2422:
2420:
2417:
2416:
2414:
2411:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2388:
2386:
2383:
2380:
2377:
2373:
2372:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2347:
2345:
2342:
2338:
2337:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2316:
2313:
2312:
2310:
2307:
2304:
2303:
2301:
2299:
2295:
2292:
2290:
2286:
2283:
2280:
2271:
2267:
2263:
2257:
2254:
2252:
2249:
2248:
2246:
2243:
2231:
2227:
2223:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2184:
2182:
2179:
2172:
2168:
2162:
2159:
2158:
2156:
2153:
2149:
2145:
2139:
2136:
2134:
2131:
2130:
2128:
2125:
2121:
2117:
2111:
2108:
2106:
2103:
2099:
2098:Class II PI 3
2096:
2094:
2091:
2090:
2089:
2086:
2084:
2081:
2079:
2076:
2074:
2073:Deoxycytidine
2071:
2069:
2066:
2064:
2061:
2059:
2056:
2054:
2051:
2049:
2046:
2042:
2041:ADP-thymidine
2039:
2038:
2037:
2034:
2032:
2029:
2027:
2024:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1996:
1995:
1992:
1990:
1987:
1983:
1980:
1979:
1978:
1975:
1973:
1970:
1968:
1965:
1964:
1962:
1959:
1955:
1951:
1948:
1945:
1937:
1933:
1927:
1922:
1918:
1914:
1907:
1902:
1900:
1895:
1893:
1888:
1887:
1884:
1874:
1870:
1866:
1862:
1858:
1854:
1850:
1846:
1839:
1836:
1831:
1827:
1822:
1817:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1782:
1779:
1774:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1742:
1735:
1732:
1727:
1723:
1718:
1713:
1709:
1705:
1702:(4): 259–78.
1701:
1697:
1693:
1686:
1683:
1678:
1674:
1670:
1666:
1662:
1658:
1654:
1650:
1643:
1640:
1635:
1631:
1627:
1623:
1618:
1613:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1578:
1575:
1570:
1566:
1561:
1556:
1552:
1548:
1544:
1540:
1536:
1529:
1526:
1521:
1517:
1512:
1507:
1503:
1499:
1495:
1488:
1485:
1480:
1476:
1471:
1466:
1462:
1458:
1454:
1450:
1446:
1439:
1436:
1431:
1427:
1423:
1419:
1414:
1409:
1405:
1401:
1397:
1390:
1387:
1382:
1378:
1374:
1370:
1365:
1360:
1356:
1352:
1348:
1341:
1338:
1333:
1329:
1325:
1321:
1317:
1313:
1310:(2): e49–61.
1309:
1305:
1297:
1294:
1289:
1283:
1280:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1240:
1237:
1232:
1228:
1223:
1218:
1214:
1210:
1207:(4): 531–40.
1206:
1202:
1198:
1191:
1188:
1183:
1179:
1175:
1171:
1167:
1163:
1155:
1152:
1147:
1143:
1139:
1135:
1131:
1127:
1123:
1119:
1112:
1109:
1104:
1100:
1096:
1092:
1087:
1082:
1079:(2): 189–93.
1078:
1074:
1070:
1063:
1061:
1057:
1052:
1048:
1043:
1038:
1034:
1030:
1026:
1022:
1018:
1011:
1008:
1003:
999:
995:
991:
987:
983:
980:(6): 446–56.
979:
975:
968:
966:
964:
962:
960:
958:
956:
954:
952:
950:
948:
946:
944:
940:
935:
931:
927:
923:
918:
913:
909:
905:
901:
897:
893:
886:
884:
882:
880:
876:
870:
866:
863:
862:
858:
856:
853:
849:
844:
842:
838:
834:
830:
826:
822:
818:
807:
798:
794:
791:This section
789:
786:
782:
781:
775:
772:
764:
762:
760:
756:
752:
747:
746:
742:
739:
735:
730:
726:
725:
721:
719:
711:
709:
707:
703:
699:
694:
692:
688:
684:
671:
668:
664:
661:
658:
654:
649:
645:
642:
639:
637:
633:
630:
627:
625:
621:
618:
615:
613:
609:
606:
603:
601:
597:
594:
591:
589:
585:
581:
577:
572:
567:
556:
553:
549:
546:
543:
539:
534:
530:
527:
524:
522:
518:
515:
512:
510:
506:
503:
500:
498:
494:
491:
488:
486:
482:
479:
476:
474:
470:
467:
464:
460:
455:
450:
444:
438:
435:
432:
431:
430:
429:
421:
417:
413:
409:
406:
402:
398:
395:
391:
388:
384:
380:
377:
373:
369:
365:
364:
363:
362:
358:
356:
352:
351:stress fibers
342:
338:
335:
331:
327:
326:
325:
324:
323:
321:
317:
310:
307:
306:
305:
303:
299:
292:
289:
288:
287:
285:
281:
277:
272:
271:
269:
263:
261:
257:
254:
245:
238:
236:
233:
229:
227:
223:
219:
215:
211:
207:
203:
199:
195:
194:contractility
191:
187:
183:
179:
175:
171:
170:stress fibers
166:
164:
161:region and a
160:
156:
153:
149:
145:
141:
140:
135:
134:
129:
128:
123:
119:
114:
112:
108:
104:
100:
96:
88:
85:
83:
79:
74:
71:
68:
66:
62:
58:
54:
50:
46:
41:
34:
29:
24:
19:
5746:
5681:
5660:
5432:
5296:eIF-2 kinase
4744:
4181:P70S6 kinase
2796:
2774:
2749:
2370:
2335:
2093:Class I PI 3
2058:Pantothenate
1929:2.7.1-2.7.4:
1913:Transferases
1848:
1844:
1838:
1795:
1791:
1781:
1748:
1744:
1734:
1699:
1695:
1685:
1652:
1648:
1642:
1594:(1): 47–62.
1591:
1587:
1577:
1542:
1538:
1528:
1501:
1497:
1487:
1452:
1448:
1438:
1403:
1399:
1389:
1357:(1): 12–23.
1354:
1350:
1340:
1307:
1303:
1296:
1282:
1249:
1245:
1239:
1204:
1200:
1190:
1165:
1161:
1154:
1121:
1117:
1111:
1076:
1073:FEBS Letters
1072:
1024:
1020:
1010:
977:
973:
902:(2): 171–7.
899:
895:
845:
814:
804:January 2020
801:
797:adding to it
792:
748:
744:
743:
731:
727:
723:
722:
715:
695:
680:
427:
426:
360:
359:
348:
313:
308:
295:
290:
273:
265:
264:
260:cytoskeleton
250:
230:
167:
146:of 158
137:
136:, mosquito,
131:
125:
115:
111:cytoskeleton
98:
94:
93:
56:Alt. symbols
4983:GNA15/GNA16
4769:Calcineurin
4632:(EC 2.7.12)
4019:Polo kinase
3959:Polo kinase
2644:Transposase
2634:Recombinase
2279:-nucleoside
2105:Sphingosine
660:Swiss-model
574:Identifiers
545:Swiss-model
457:Identifiers
416:growth cone
387:cytokinesis
372:phosphatase
341:phosphatase
316:contraction
302:ADF/cofilin
284:phosphatase
270:as follows:
188:binding of
159:coiled-coil
43:Identifiers
5769:Cell cycle
5763:Categories
5389:Lim kinase
5340:IκB kinase
4861:Transducin
3310:IκB kinase
2885:2.7.11-12)
2446:Telomerase
2289:Polymerase
2063:Mevalonate
2026:Riboflavin
1917:phosphorus
871:References
765:Inhibitors
718:Rho GTPase
712:Regulation
691:amino acid
656:Structures
651:Search for
541:Structures
536:Search for
445:Homologues
440:membrane).
383:centrioles
298:LIM kinase
139:Drosophila
133:C. elegans
76:Other data
5774:EC 2.7.11
5747:see also
5653:Apoptosis
5134:Monomeric
4866:Gustducin
4784:G protein
3436:PKC alpha
2638:Integrase
2562:3' to 5'
2207:Guanylate
2202:Uridylate
2192:Adenylate
2036:Thymidine
2031:Shikimate
1865:1520-4804
1812:0304-3835
1765:0304-3835
1669:1873-5592
1634:210043399
1608:1744-7631
751:activator
738:PH domain
629:NM_004850
588:NCBI gene
514:NM_005406
473:NCBI gene
419:collapse.
405:apoptosis
190:myosin II
82:EC number
65:NCBI gene
5605:Tyrosine
5550:Arginine
5467:Tyrosine
3792:KIAA0999
3687:MAPKAPK5
3682:MAPKAPK3
3677:MAPKAPK2
2572:RNase PH
2180:acceptor
2161:Creatine
2154:acceptor
2126:acceptor
2068:Pyruvate
2053:Glycerol
2014:Platelet
1989:Galacto-
1960:acceptor
1873:26486225
1830:25172415
1773:25796438
1726:26725045
1677:27033194
1626:31906742
1569:29057688
1520:12006612
1430:39115039
1422:11146558
1400:Oncogene
1381:16144917
1332:45342422
1324:15218323
1274:19316266
1266:15793569
1231:19131646
1182:10436159
1146:20486807
1138:29306925
1002:40665081
994:12778124
926:19907920
917:11115778
859:See also
852:RKI-1447
850:such as
687:homology
670:InterPro
555:InterPro
355:integrin
239:Function
87:2.7.11.1
5731:EDARADD
5716:Mucin-4
5455:RPS6KA1
5301:EIF2AK3
4757:Calcium
4451:MAP3K14
4429:MAP3K11
4424:MAP3K10
4414:MAP3K13
4409:MAP3K12
4211:RPS6KC1
4206:RPS6KA1
4201:RPS6KA3
4196:RPS6KA2
4191:RPS6KB2
4176:RPS6KA4
4171:RPS6KA5
3822:Kalirin
3787:SNF1LK2
3026:EIF2AK4
3021:EIF2AK3
2875:Kinases
2523:PrimPol
2508:Primase
1982:Hepatic
1977:Fructo-
1821:4182185
1717:4930737
1617:7662835
1560:6221831
1479:9832553
1470:2133074
1373:8999996
1222:2649695
1162:Science
1103:6684411
1095:8772201
1051:8816443
934:6445354
776:Disease
666:Domains
636:UniProt
551:Domains
521:UniProt
412:neurite
394:insulin
127:Xenopus
116:ROCKs (
101:) is a
18:Rho Chi
5736:PRKCSH
5575:Other
5524:DYRK1B
5519:DYRK1A
5259:Other
5229:Cyclin
5212:Cyclin
4681:MAP2K7
4676:MAP2K6
4671:MAP2K5
4666:MAP2K4
4661:MAP2K3
4656:MAP2K2
4651:MAP2K1
4602:ACVRL1
4597:ACVR2B
4592:ACVR2A
4587:ACVR1C
4582:ACVR1B
4565:BMPR1B
4560:BMPR1A
4434:MAP3K7
4419:MAP3K9
4370:MAP3K8
4365:MAP3K7
4360:MAP3K6
4355:MAP3K5
4350:MAP3K4
4345:MAP3K3
4340:MAP3K2
4335:MAP3K1
4309:MAPK14
4304:MAPK13
4299:MAPK11
4287:MAPK10
4265:MAPK15
4260:MAPK12
4152:CDC2L1
4127:CDC2L5
3802:SNF1LK
3627:CAMK2G
3622:CAMK2D
3617:CAMK2B
3612:CAMK2A
3602:CAMK1G
3597:CAMK1D
3592:CAMK1B
3587:CAMK1A
3441:PRKCB1
3378:PRKACA
3373:PRKACB
3368:PRKACG
3344:IKBKAP
3170:BCKDHB
3165:BCKDHA
3139:PRKAG3
3134:PRKAG2
3129:PRKAG1
3119:PRKAB2
3114:PRKAB1
3104:PRKAA2
3099:PRKAA1
2944:STK38L
2810:2.7.13
2788:2.7.12
2763:2.7.11
2738:2.7.10
2577:PNPase
2545:PNPase
2501:POLRMT
2496:ssRNAP
2009:Muscle
1972:Gluco-
1936:kinase
1871:
1863:
1828:
1818:
1810:
1771:
1763:
1724:
1714:
1675:
1667:
1632:
1624:
1614:
1606:
1567:
1557:
1518:
1477:
1467:
1428:
1420:
1379:
1371:
1330:
1322:
1272:
1264:
1229:
1219:
1180:
1144:
1136:
1101:
1093:
1049:
1042:231530
1039:
1000:
992:
932:
924:
914:
833:cancer
831:, and
827:, and
706:motifs
641:O75116
624:RefSeq
617:604002
579:Symbol
526:Q13464
509:RefSeq
502:601702
462:Symbol
334:ATPase
320:myosin
280:myosin
276:kinase
253:GTPase
218:testis
214:kidney
210:spleen
184:, the
152:GTPase
103:kinase
70:579202
48:Symbol
5694:Other
5632:both:
5539:DYRK4
5534:DYRK3
5529:DYRK2
5491:PTK2B
5476:ZAP70
5443:ROCK2
5438:ROCK1
5399:LIMK2
5394:LIMK1
5382:IRAK4
5377:IRAK3
5372:IRAK2
5367:IRAK1
5355:IKBKG
5333:GSK3B
5328:GSK3A
5323:GSK-3
5238:Lipid
5189:Rhebs
5100:BSCL2
5095:GNG13
5090:GNG12
5085:GNG11
5080:GNG10
5045:GNGT2
5040:GNGT1
4978:GNA14
4973:GNA13
4968:GNA12
4963:GNA11
4938:GNAT3
4933:GNAT2
4928:GNAT1
4923:GNAI3
4918:GNAI2
4913:GNAI1
4908:GNAO1
4643:MAP2K
4577:ACVR1
4570:BMPR2
4555:BMPR1
4480:GSK-3
4321:MAP3K
4282:MAPK9
4277:MAPK8
4255:MAPK7
4250:MAPK6
4245:MAPK4
4240:MAPK3
4235:MAPK1
4147:PFTK1
4142:PCTK3
4137:PCTK2
4132:PCTK1
4122:CDK12
4117:CDK10
4092:CDKL5
4072:CDKL2
3949:STK19
3944:EEF2K
3925:PHKG2
3920:PHKG1
3910:PHKA2
3905:PHKA1
3886:MYLK4
3881:MYLK3
3876:MYLK2
3852:DCLK1
3847:Titin
3837:TRIB3
3832:TRIB2
3827:TRIB1
3817:TSSK2
3797:STK40
3782:PSKH1
3777:PRKD3
3772:PRKD2
3752:PHKG2
3747:PHKG1
3737:OBSCN
3732:NUAK2
3727:NUAK1
3722:MKNK2
3717:MKNK1
3707:MARK4
3702:MARK3
3697:MARK2
3692:MARK1
3672:STK11
3667:DAPK3
3662:DAPK2
3657:DAPK1
3652:CHEK2
3647:CHEK1
3632:CAMK4
3607:CAMK2
3582:CAMK1
3577:BRSK2
3471:PRKCQ
3466:PRKCI
3461:PRKCG
3456:PRKCH
3451:PRKCE
3446:PRKCD
3407:PRKG1
3339:IKBKG
3334:IKBKE
3283:STK10
3278:FASTK
3204:IDH3G
3199:IDH3B
3194:IDH3A
3160:BCKDK
2954:ROCK1
2939:STK38
2934:MAST2
2929:MAST1
2924:LATS2
2919:LATS1
2658:2.7.8
2627:Other
2266:2.7.7
2226:2.7.6
2171:2.7.4
2148:2.7.3
2120:2.7.2
2004:Liver
1967:Hexo-
1954:2.7.1
1630:S2CID
1426:S2CID
1377:S2CID
1328:S2CID
1270:S2CID
1142:S2CID
1099:S2CID
998:S2CID
930:S2CID
865:ROCK1
702:Cdc42
683:ROCK1
605:10252
582:ROCK2
490:10251
466:ROCK1
376:tumor
226:heart
222:brain
206:liver
198:ROCK1
186:actin
122:ROCK2
118:ROCK1
5682:see
5661:see
5562:McsB
5486:PTK2
5426:PAK4
5421:PAK3
5416:PAK2
5411:PAK1
5350:IKK2
5345:CHUK
5318:GSK2
5313:GSK1
5199:RGKs
5194:Raps
5179:Arfs
5174:Rhos
5167:NRAS
5162:KRAS
5157:HRAS
5147:Rabs
5142:ARFs
5075:GNG8
5070:GNG7
5065:GNG5
5060:GNG4
5055:GNG3
5050:GNG2
5027:GNB5
5022:GNB4
5017:GNB3
5012:GNB2
5007:GNB1
4958:GNAQ
4953:GNAL
4948:GNAS
4943:GNAZ
4876:cGMP
4852:cGMP
4832:cAMP
4802:cAMP
4745:see
4470:TPK1
4446:CDC7
4404:MLKs
4397:KSR2
4392:KSR1
4387:BRAF
4382:ARAF
4377:RAFs
4112:CDK9
4107:CDK8
4102:CDK7
4097:CDK6
4087:CDK5
4082:CDK4
4077:CDK3
4067:CDK2
4062:CDK1
4043:PLK4
4038:PLK3
4033:PLK2
4028:PLK1
3983:PLK4
3978:PLK3
3973:PLK2
3968:PLK1
3915:PHKB
3871:MYLK
3842:TRIO
3812:SPEG
3807:SNRK
3767:PKD1
3762:PIM2
3757:PIM1
3742:PASK
3712:MELK
3642:CASK
3637:MLCK
3558:GRK6
3553:GRK5
3548:GRK4
3486:PKN3
3481:PKN2
3383:PRKY
3329:TBK1
3324:IKK2
3319:CHUK
3223:STK4
3189:IDH2
3074:PDK4
3069:PDK3
3064:PDK2
3059:PDK1
3038:WEE1
3033:Wee1
3001:mTOR
2989:AKT3
2984:AKT2
2979:AKT1
2969:SGK3
2964:SGK2
2797:see
2775:see
2750:see
2124:COOH
1923:2.7)
1869:PMID
1861:ISSN
1826:PMID
1808:ISSN
1769:PMID
1761:ISSN
1722:PMID
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