796:
255:
44:
315:, thereby inactivating its actin-depolymerization activity. This results in the stabilization of actin filaments and an increase in their numbers. Thus, over time actin monomers that are needed to continue actin polymerization for migration become limited. The increased stable actin filaments and the loss of actin monomers contribute to a reduction of cell migration.
739:
ROCK activity is regulated by the disruption of an intramolecular autoinhibition. In general, the structure of ROCK proteins consists of an N-terminal kinase domain, a coiled-coiled region and a PH domain containing a cystein-rich domain (CRD) at the C-terminal. A Rho-binding domain (RBD) is located
751:
to the N-terminal kinase domain of ROCK. Thus, the kinase activity is off when ROCK is intramolecularly folded. The kinase activity is switched on when Rho-GTP binds to the Rho-binding domain of ROCK, disrupting the autoinhibitory interaction within ROCK, which liberates the kinase domain because
433:
ROCKs regulate cell-cell adhesion: Loss of ROCK activity seems to lead to loss of tight junction integrity in endothelial cells. In epithelial cells inhibition of ROCK seems to decrease tight junction integrity. Active ROCK in these cells seems to stimulate the disruption of E-Cadherin-mediated
245:
and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells.
418:. The pro-apoptotic protease, caspase 3, activates ROCK kinase activity by cleaving the C-terminal PH domain. As a result, the autoinhibitory intramolecular fold of ROCK is abolished. ROCK also regulates MLC phosphorylation and actomyosin contractility, which regulate membrane blebbing.
1312:
Gao SY, Li CY, Chen J, Pan L, Saito S, Terashita T, Saito K, Miyawaki K, Shigemoto K, Mominoki K, Matsuda S, Kobayashi N (2004). "Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted process elongation".
450:
F-actin binding proteins: Adducin, EF-1&alpha (elongation factor, translation co-factor), MARCKS (myristylated alanine-rich C kinase substrate), Caponin (unknown function), and ERM (involved in linkage of the actin cytoskelton to the plasma
429:
collapse by activating actomyosin contractility. It is also possible that phosphorylation of collapsin response mediator protein-2 (CRMP2) by ROCK inhibits CRPM2 function of promoting axon outgrowth, resulting in growth cone
4732:
5759:
2684:
1170:
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (August 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase".
2876:
865:
for treating various diseases including cancer. For example, such drugs have potential to prevent cancer from spreading by blocking cell migration, stopping cancer cells from spreading into neighboring tissue.
3161:
347:
activity. Thus several bundled and active myosins, which are asynchronously active on several actin filaments, move actin filaments against each other, resulting in the net shortenting of actin fibres.
1797:
Kale, Vijay
Pralhad; Hengst, Jeremy A.; Desai, Dhimant H.; Dick, Taryn E.; Choe, Katherine N.; Colledge, Ashley L.; Takahashi, Yoshinori; Sung, Shen-Shu; Amin, Shantu G.; Yun, Jong K. (2014-11-28).
850:. ROCK1/2 along with MRCKα/β kinases have been implicated in the plasticity of cancer cell migration, the phenomenon which bestows survival advantage to the cancer cells during drug treatments (
4725:
2694:
2689:
2869:
4718:
5633:
2862:
2809:
2787:
3069:
2605:
389:
suppressor protein. This stimulation seems to depend on ROCK. In this way, PTEN is important to prevent uncontrolled cell division as is exhibited in cancer cells.
364:, actin filament bundles of opposing polarity, containing myosin II, tropomyosin, caldesmon and MLC-kinase, and consequently of focal contacts, which are immature
4741:
598:
483:
75:
3617:
4456:
2920:
4565:
2715:
1456:"Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments"
1407:"Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow"
715:)-binding kinases (MRCK) and citron kinase. All of these kinases are composed of a N-terminal kinase domain, a coiled-coil structure and other functional
3303:
3190:
4784:
3578:
5229:
2610:
5736:
5372:
5280:
5177:
4551:
4016:
2907:
2889:
2777:
117:
4891:
4847:
5694:
4653:
4534:
1255:
Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D (April 2005). "Regulation of PTEN by Rho small GTPases".
4774:
4240:
3109:
4304:
3279:
2416:
5673:
5596:
4560:
3094:
622:
507:
5716:
4617:
4292:
2550:
5125:
3549:
3539:
3224:
2120:
1914:
1658:
Chong CM, Ai N, Lee SM (2017). "ROCK in CNS: Different Roles of
Isoforms and Therapeutic Target for Neurodegenerative Disorders".
5255:
4231:
2261:
1298:
1028:"The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton"
610:
495:
5628:
80:
4500:
4172:
3534:
3525:
1505:"Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo"
603:
488:
5684:
4886:
4862:
4842:
176:(PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present.
5491:
4896:
3915:
3412:
3403:
3060:
3006:
2834:
2829:
2389:
2207:
839:
262:
ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small
5649:
5624:
5615:
5477:
5130:
3103:
2699:
2587:
2555:
2540:
396:
in G1, and is proposed to be required for contraction of the cleavage furrow, which is necessary for the completion of
4757:
2222:
5508:
2854:
826:
Research over the past two decades has shown that ROCK signaling plays an important role in many diseases including
4127:
3945:
3441:
1854:
Feng Y, LoGrasso PV, Defert O, Li R (March 2016). "Rho Kinase (ROCK) Inhibitors and Their
Therapeutic Potential".
5789:
4117:
4112:
4107:
4097:
4092:
4087:
4077:
3872:
3647:
3243:
2820:
2798:
2773:
2748:
2668:
2276:
2236:
2181:
2158:
2130:
2098:
1964:
447:
intermediate filament proteins: Vimentin, GFAP (glial fibrillaric acidic protein), NF-L (neurofilament L protein)
2051:
1799:"A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion"
1080:"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice"
5731:
5318:
4821:
4803:
4340:
4331:
4282:
3048:
2893:
2285:
2266:
2197:
1931:
92:
1595:"Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening"
297:. These substrates, once phosphorylated, regulate actin filament organization and contractility as follows:
5524:
5234:
5204:
5189:
5152:
4640:
4063:
2143:
708:
392:
ROCK plays an important role in cell cycle control, it seems to inhibit the premature separation of the two
4812:
2597:
2370:
2280:
835:
831:
827:
615:
500:
143:
5605:
5416:
5184:
3339:
2451:
2406:
2108:
2093:
2029:
2009:
1907:
728:
266:
1750:
Kale, Vijay
Pralhad; Hengst, Jeremy A.; Desai, Dhimant H.; Amin, Shantu G.; Yun, Jong K. (2015-06-01).
1892:
5008:
3906:
2365:
2360:
2240:
2103:
2083:
1992:
1751:
858:
781:
761:
744:
307:
ROCK inhibits the depolymerization of actin filaments indirectly: ROCK phosphorylates and activates
5779:
5587:
5460:
2628:
2620:
2401:
2068:
2004:
1968:
173:
4414:
1454:
Yasui Y, Amano M, Nagata K, Inagaki N, Nakamura H, Saya H, Kaibuchi K, Inagaki M (November 1998).
5784:
4993:
4958:
4517:
4471:
2491:
2429:
2380:
2115:
1942:
1640:
1436:
1387:
1338:
1280:
1208:"ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells"
1152:
1109:
1008:
940:
697:
4710:
4881:
4837:
3777:
3486:
2506:
2496:
2486:
2411:
2395:
2354:
2340:
2335:
2073:
2036:
1879:
1871:
1836:
1818:
1779:
1771:
1732:
1683:
1675:
1632:
1614:
1575:
1526:
1485:
1428:
1379:
1330:
1272:
1237:
1188:
1144:
1101:
1057:
1000:
932:
411:
4852:
4830:
4826:
4370:
3612:
3602:
3597:
3515:
3506:
3436:
3427:
3373:
3364:
3021:
2839:
2501:
2481:
2423:
2319:
2217:
2202:
2148:
2046:
2041:
1900:
1863:
1826:
1810:
1763:
1722:
1714:
1667:
1622:
1606:
1565:
1557:
1516:
1475:
1467:
1418:
1369:
1322:
1264:
1227:
1219:
1180:
1136:
1091:
1047:
1039:
992:
922:
914:
765:
242:
158:
5549:
5090:
1299:"Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1)"
97:
5572:
5567:
5328:
5323:
5299:
5294:
5260:
5157:
5085:
4909:
4196:
3267:
3262:
3257:
2762:
2752:
2574:
2545:
2171:
2078:
2063:
1752:"The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration"
851:
769:
670:
555:
192:
184:
179:
Rat ROCKs were discovered as the first effectors of Rho and they induce the formation of
927:
902:
5271:
2730:
2569:
2476:
2468:
2345:
2308:
1831:
1798:
1727:
1702:
1627:
1594:
1570:
1545:
1480:
1455:
1232:
1207:
716:
326:
278:
154:
120:. It is involved mainly in regulating the shape and movement of cells by acting on the
1671:
1374:
1357:
1052:
1027:
795:
444:
NHE1 (a sodium hydrogen exchanger, involved in focal adhesions and actin organisation)
254:
5773:
5350:
5289:
5162:
3320:
3252:
1999:
1644:
1405:
Kosako H, Yoshida T, Matsumura F, Ishizaki T, Narumiya S, Inagaki M (December 2000).
1096:
1079:
983:
Riento K, Ridley AJ (June 2003). "Rocks: multifunctional kinases in cell behaviour".
204:
1440:
1391:
1342:
1284:
1156:
1127:
Anjum I (June 2018). "Calcium sensitization mechanisms in detrusor smooth muscles".
1012:
329:
and thus cell-substratum contacts. ROCK increases the activity of the motor protein
5306:
5144:
4191:
3016:
2088:
2058:
1987:
1113:
944:
903:"Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity"
361:
270:
180:
121:
1610:
1561:
1223:
1206:
Wang Y, Zheng XR, Riddick N, Bryden M, Baur W, Zhang X, Surks HK (February 2009).
707:
ROCKs are homologous to other metazoan kinases such as myotonic dystrophy kinase (
1867:
1814:
1767:
1184:
639:
524:
407:
signaling pathway, resulting in a reduction of cell size and influence cell fate.
5209:
4779:
4397:
4029:
3969:
3852:
3772:
3496:
2654:
2644:
2245:
1982:
1923:
1078:
Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S (August 1996).
680:
565:
426:
397:
382:
378:
351:
294:
169:
5399:
5194:
4871:
4485:
2959:
2456:
2299:
2212:
1977:
1927:
1718:
918:
701:
646:
531:
393:
308:
149:
5721:
1875:
1822:
1775:
1679:
1618:
5663:
4876:
4794:
3446:
2735:
2648:
2185:
1951:
1521:
1504:
1140:
748:
415:
200:
43:
1883:
1840:
1783:
1736:
1687:
1636:
1579:
1530:
1471:
1432:
1423:
1406:
1334:
1276:
1241:
1192:
1148:
1043:
1004:
936:
846:. For example, ROCK has been hypothesized to play an important role in the
1489:
1383:
1105:
1061:
360:
Thus in both cases, ROCK activation by Rho induces the formation of actin
17:
3802:
3697:
3692:
3687:
2582:
2162:
862:
651:
536:
365:
277:
1. ROCK is a key regulator of actin organization and thus a regulator of
5741:
5465:
5311:
4461:
4439:
4434:
4424:
4419:
4221:
4216:
4211:
4206:
4201:
4186:
4181:
3832:
3797:
3036:
3031:
3026:
2533:
2518:
2134:
1358:"A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos"
422:
404:
312:
137:
28:
1326:
5746:
5534:
5529:
5239:
4691:
4686:
4681:
4676:
4671:
4666:
4661:
4612:
4607:
4602:
4597:
4592:
4575:
4570:
4444:
4429:
4380:
4375:
4360:
4355:
4350:
4345:
4319:
4314:
4309:
4297:
4275:
4270:
4162:
4137:
3812:
3637:
3632:
3627:
3622:
3607:
3451:
3388:
3383:
3378:
3354:
3180:
3175:
3149:
3144:
3139:
3129:
3124:
3114:
2954:
2885:
2511:
1946:
847:
843:
634:
519:
344:
340:
330:
290:
286:
263:
228:
224:
220:
188:
162:
113:
1268:
996:
285:
Different substrates can be phosphorylated by ROCKs, including LIM
5544:
5539:
5501:
5486:
5453:
5448:
5409:
5404:
5392:
5387:
5382:
5377:
5365:
5343:
5338:
5333:
5110:
5105:
5100:
5095:
5055:
5050:
4988:
4983:
4978:
4973:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4587:
4580:
4490:
4387:
4287:
4265:
4260:
4255:
4250:
4245:
4157:
4152:
4147:
4142:
4132:
4102:
4082:
3959:
3954:
3935:
3930:
3920:
3896:
3891:
3886:
3862:
3857:
3847:
3842:
3837:
3827:
3807:
3792:
3787:
3782:
3762:
3757:
3747:
3742:
3737:
3732:
3727:
3717:
3712:
3707:
3702:
3682:
3677:
3672:
3667:
3662:
3657:
3642:
3592:
3587:
3481:
3476:
3471:
3466:
3461:
3456:
3417:
3349:
3344:
3293:
3288:
3214:
3209:
3204:
3170:
3162:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2964:
2949:
2944:
2939:
2934:
2929:
2528:
2523:
2375:
875:
712:
704:
sequences in common and 92% homology within their kinase domains.
693:
476:
386:
236:
232:
216:
208:
196:
132:
128:
2685:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
211:
and ROCK2 have been identified. ROCK1 is mainly expressed in the
5726:
5711:
5496:
5436:
5431:
5426:
5421:
5360:
5355:
5199:
5172:
5167:
5080:
5075:
5070:
5065:
5060:
5037:
5032:
5027:
5022:
5017:
4968:
4963:
4953:
4480:
4407:
4402:
4392:
4365:
4122:
4072:
4053:
4048:
4043:
4038:
3993:
3988:
3983:
3978:
3925:
3881:
3822:
3817:
3767:
3752:
3722:
3652:
3568:
3563:
3558:
3491:
3393:
3334:
3329:
3233:
3199:
3084:
3079:
3074:
3043:
3011:
2999:
2994:
2989:
2979:
2974:
2439:
2434:
2330:
2325:
2024:
2019:
2014:
1701:
Wei L, Surma M, Shi S, Lambert-Cheatham N, Shi J (August 2016).
627:
512:
212:
165:
4714:
4638:
4014:
2905:
2858:
1896:
4449:
2984:
2969:
790:
764:
of ROCK. ROCK can also be regulated by lipids, in particular
747:
binding between the C-terminal cluster of RBD domain and the
5760:
deficiencies of intracellular signaling peptides and proteins
377:
RhoA-GTP stimulates the phospholipid phosphatase activity of
731:
Rho that increases ROCK kinase activity when bound to it.
434:
cell-cell contacts by activating actomyosin contractility.
1356:
Drechsel DN, Hyman AA, Hall A, Glotzer M (January 1997).
1129:
Journal of Basic and
Clinical Physiology and Pharmacology
368:-based adhesion points with the extracellular substrate.
325:
ROCK also regulates cell migration by promoting cellular
135:) occur in mammals (human, rat, mouse, cow), zebrafish,
1703:"Novel Insights into the Roles of Rho Kinase in Cancer"
807:
580:
Rho-associated, coiled-coil-containing protein kinase 2
463:
Rho-associated, coiled-coil-containing protein kinase 1
1593:
Yu B, Sladojevic N, Blair JE, Liao JK (January 2020).
2695:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
70:
Rho-associated, coiled-coil-containing protein kinase
2700:
CDP-diacylglycerol—choline O-phosphatidyltransferase
414:, a morphological change seen in cells committed to
354:, leading to increased levels of phosphorylated MLC.
339:
Firstly, phosphorylation of the myosin light chain (
5704:
5683:
5662:
5642:
5614:
5595:
5585:
5560:
5517:
5476:
5279:
5269:
5248:
5222:
5143:
4861:
4811:
4802:
4793:
4767:
4748:
4652:
4550:
4533:
4516:
4499:
4470:
4330:
4230:
4171:
4062:
4028:
3968:
3944:
3905:
3871:
3577:
3548:
3524:
3505:
3426:
3402:
3363:
3319:
3302:
3278:
3242:
3223:
3189:
3160:
3093:
3059:
2919:
2819:
2797:
2772:
2747:
2728:
2708:
2690:
CDP-diacylglycerol—serine O-phosphatidyltransferase
2677:
2667:
2637:
2619:
2596:
2568:
2467:
2307:
2298:
2275:
2235:
2180:
2157:
2129:
1963:
1939:
740:in close proximity just in front of the PH domain.
676:
666:
661:
645:
633:
621:
609:
597:
589:
584:
579:
561:
551:
546:
530:
518:
506:
494:
482:
472:
467:
462:
91:
86:
74:
66:
58:
53:
36:
5634:Sh2 domain-containing protein tyrosine phosphatase
1546:"ROCK as a therapeutic target for ischemic stroke"
1026:Leung T, Chen XQ, Manser E, Lim L (October 1996).
711:), DMPK-related cell division control protein 42 (
1707:Archivum Immunologiae et Therapiae Experimentalis
772:, which induces N-terminal transphosphorylation.
760:It has also been shown that Rho is not the only
752:ROCK is then no longer intramolecularly folded.
168:. Mammalian ROCK consists of a kinase domain, a
161:and is a major downstream effector of the small
978:
976:
974:
972:
970:
968:
966:
964:
962:
960:
958:
956:
954:
896:
894:
892:
890:
727:ROCK is a downstream effector molecule of the
269:, which is one of the major regulators of the
231:. However, ROCK2 is distributed mostly in the
116:belonging to the AGC (PKA/ PKG/PKC) family of
4742:Intracellular signaling peptides and proteins
4726:
2921:Non-specific serine/threonine protein kinases
2870:
1908:
1544:Sladojevic N, Yu B, Liao JK (December 2017).
1073:
1071:
8:
2716:N-acetylglucosamine-1-phosphate transferase
2606:UTP—glucose-1-phosphate uridylyltransferase
5629:Receptor-like protein tyrosine phosphatase
5592:
5276:
4808:
4799:
4733:
4719:
4711:
4649:
4635:
4025:
4011:
3304:Goodpasture-antigen-binding protein kinase
2916:
2902:
2877:
2863:
2855:
2744:
2674:
2304:
2295:
1960:
1915:
1901:
1893:
658:
543:
42:
5230:Cyclin-dependent kinase inhibitor protein
4017:Serine/threonine-specific protein kinases
3191:(isocitrate dehydrogenase (NADP+)) kinase
2908:Serine/threonine-specific protein kinases
2890:Serine/threonine-specific protein kinases
2810:serine/threonine-specific protein kinases
2788:serine/threonine-specific protein kinases
2611:Galactose-1-phosphate uridylyltransferase
1830:
1726:
1626:
1569:
1520:
1479:
1422:
1373:
1231:
1095:
1051:
926:
118:serine-threonine specific protein kinases
5737:Phosphatidylethanolamine binding protein
5373:Interleukin-1 receptor associated kinase
4785:Ca2+/calmodulin-dependent protein kinase
4552:Receptor protein serine/threonine kinase
743:The kinase activity is inhibited by the
253:
4535:Low-density-lipoprotein receptor kinase
901:Hahmann C, Schroeter T (January 2010).
886:
5492:Focal adhesion protein-tyrosine kinase
4775:Intracellular calcium-sensing proteins
985:Nature Reviews. Molecular Cell Biology
576:
459:
33:
3280:Fas-activated serine/threonine kinase
1599:Expert Opinion on Therapeutic Targets
830:, neurodegenerative diseases such as
7:
4561:Bone morphogenetic protein receptors
907:Cellular and Molecular Life Sciences
3095:Dephospho-(reductase kinase) kinase
207:increases. Two mouse ROCK isoforms
5717:Signal transducing adaptor protein
4892:3',5'-cyclic-GMP phosphodiesterase
4848:3',5'-cyclic-AMP phosphodiesterase
3550:G-protein coupled receptor kinases
1550:Expert Review of Neurotherapeutics
403:ROCKs also seem to antagonize the
191:(myosin light chain). Due to this
25:
5712:Activating transcription factor 6
5126:G protein-coupled receptor kinase
3540:Beta adrenergic receptor kinase-2
3225:(tyrosine 3-monooxygenase) kinase
2121:Glucose-1,6-bisphosphate synthase
1672:10.2174/1389450117666160401123825
1503:Piekny AJ, Mains PE (June 2002).
153:) and chicken. Human ROCK1 has a
48:Crystal structure of human ROCK I
5256:Phosphoinositide phospholipase C
4232:Mitogen-activated protein kinase
2262:Ribose-phosphate diphosphokinase
794:
333:II by two different mechanisms:
4618:Anti-Müllerian hormone receptor
4501:(acetyl-CoA carboxylase) kinase
4173:(RNA-polymerase)-subunit kinase
3535:Beta adrenergic receptor kinase
3526:Beta adrenergic receptor kinase
1315:Nephron Experimental Nephrology
385:and tensin homologue), a human
350:Secondly, ROCK inactivates MLC
311:, which in turn phosphorylates
5695:GTP-binding protein regulators
5685:GTP-binding protein regulators
4241:Extracellular signal-regulated
1856:Journal of Medicinal Chemistry
1032:Molecular and Cellular Biology
848:pleiotropic effects of statins
372:2. Other functions and targets
1:
5444:Rho-associated protein kinase
4305:P38 mitogen-activated protein
3404:cGMP-dependent protein kinase
3365:cAMP-dependent protein kinase
3061:Pyruvate dehydrogenase kinase
3007:Ataxia telangiectasia mutated
2835:Protein-histidine tele-kinase
2830:Protein-histidine pros-kinase
2709:Glycosyl-1-phosphotransferase
1611:10.1080/14728222.2020.1712593
1562:10.1080/14737175.2017.1395700
1375:10.1016/S0960-9822(06)00023-6
1224:10.1161/CIRCRESAHA.108.188524
840:amyotrophic lateral sclerosis
692:The two mouse ROCK isoforms,
106:Rho-associated protein kinase
62:Rho-associated protein kinase
5650:Dual-specificity phosphatase
5625:protein tyrosine phosphatase
5131:AMP-activated protein kinase
3104:AMP-activated protein kinase
2541:RNA-dependent RNA polymerase
1868:10.1021/acs.jmedchem.5b00683
1815:10.1016/j.canlet.2014.08.032
1768:10.1016/j.canlet.2015.03.017
1185:10.1126/science.285.5429.895
1097:10.1016/0014-5793(96)00811-3
5674:apoptosis signaling pathway
4019:(EC 2.7.11.21-EC 2.7.11.30)
2448:RNA-directed DNA polymerase
2316:DNA-directed DNA polymerase
1460:The Journal of Cell Biology
857:Researchers are developing
258:Role and regulation of ROCK
5806:
3946:Elongation factor 2 kinase
2910:(EC 2.7.11.1-EC 2.7.11.20)
2801:: protein-dual-specificity
779:
343:) increases the myosin II
293:light chain (MLC) and MLC
26:
5755:
5518:Serine/threonine/tyrosine
5121:
5004:
4905:
4648:
4634:
4341:MAP kinase kinase kinases
4024:
4010:
3873:Myosin light-chain kinase
3579:Ca2+/calmodulin-dependent
3244:Myosin-heavy-chain kinase
2915:
2901:
1719:10.1007/s00005-015-0382-6
919:10.1007/s00018-009-0189-x
657:
542:
302:Amount of actin filaments
41:
5732:Olfactory marker protein
5319:Glycogen synthase kinase
4822:Heterotrimeric G protein
4641:Dual-specificity kinases
2778:protein-serine/threonine
2678:Phosphatidyltransferases
2267:Thiamine diphosphokinase
27:Not to be confused with
5525:Dual-specificity kinase
5235:Cyclin-dependent kinase
4064:Cyclin-dependent kinase
1522:10.1242/jcs.115.11.2271
1509:Journal of Cell Science
1141:10.1515/jbcpp-2017-0071
425:retraction by inducing
2598:Nucleotidyltransferase
2281:nucleotidyltransferase
2208:Nucleoside-diphosphate
1472:10.1083/jcb.143.5.1249
1424:10.1038/sj.onc.1203987
1044:10.1128/mcb.16.10.5313
828:cardiovascular disease
320:Cellular contractility
259:
5606:Protein phosphatase 2
5417:p21-activated kinases
2452:Reverse transcriptase
780:Further information:
696:and ROCK2, have high
439:3. Other ROCK targets
410:ROCKS play a role in
257:
5009:G beta-gamma complex
3907:Phosphorylase kinase
2241:diphosphotransferase
2223:Thiamine-diphosphate
1930:-containing groups (
1660:Current Drug Targets
1212:Circulation Research
782:Rho kinase inhibitor
421:ROCKs contribute to
5588:protein phosphatase
5461:Ribosomal s6 kinase
2823:: protein-histidine
2741:; protein acceptor)
2629:mRNA capping enzyme
2621:Guanylyltransferase
1257:Nature Cell Biology
836:Parkinson's disease
832:Alzheimer's disease
719:at the C-terminus
187:by phosphorylating
174:Pleckstrin homology
4758:MAP kinase pathway
4518:Tropomyosin kinase
4472:Tau-protein kinase
2099:Phosphoinositide 3
1943:phosphotransferase
1515:(Pt 11): 2271–82.
806:. You can help by
260:
5767:
5766:
5722:I-kappa B protein
5658:
5657:
5581:
5580:
5218:
5217:
5139:
5138:
4882:Guanylate cyclase
4838:Adenylate cyclase
4708:
4707:
4704:
4703:
4700:
4699:
4630:
4629:
4626:
4625:
4006:
4005:
4002:
4001:
3487:Protein kinase N1
3442:Protein kinase Cζ
2852:
2851:
2848:
2847:
2724:
2723:
2663:
2662:
2564:
2563:
2477:Template-directed
2231:
2230:
2198:Phosphomevalonate
1556:(12): 1167–1177.
1327:10.1159/000078406
824:
823:
690:
689:
686:
685:
575:
574:
571:
570:
412:membrane blebbing
141:, invertebrates (
103:
102:
16:(Redirected from
5797:
5790:Protein families
5597:Serine/threonine
5593:
5281:Serine/threonine
5277:
4897:Protein kinase G
4853:Protein kinase A
4809:
4800:
4735:
4728:
4721:
4712:
4650:
4636:
4283:C-Jun N-terminal
4026:
4012:
3516:Rhodopsin kinase
3507:Rhodopsin kinase
3437:Protein kinase C
3428:Protein kinase C
3413:Protein kinase G
3374:Protein kinase A
2985:Protein kinase B
2917:
2903:
2879:
2872:
2865:
2856:
2840:Histidine kinase
2763:tyrosine kinases
2753:protein-tyrosine
2745:
2675:
2482:RNA polymerase I
2305:
2296:
2149:Aspartate kinase
2144:Phosphoglycerate
1961:
1917:
1910:
1903:
1894:
1888:
1887:
1862:(6): 2269–2300.
1851:
1845:
1844:
1834:
1794:
1788:
1787:
1747:
1741:
1740:
1730:
1698:
1692:
1691:
1655:
1649:
1648:
1630:
1590:
1584:
1583:
1573:
1541:
1535:
1534:
1524:
1500:
1494:
1493:
1483:
1451:
1445:
1444:
1426:
1402:
1396:
1395:
1377:
1353:
1347:
1346:
1309:
1303:
1302:
1295:
1289:
1288:
1252:
1246:
1245:
1235:
1203:
1197:
1196:
1167:
1161:
1160:
1124:
1118:
1117:
1099:
1075:
1066:
1065:
1055:
1023:
1017:
1016:
980:
949:
948:
930:
898:
819:
816:
798:
791:
766:arachidonic acid
756:Other regulators
700:. They have 65%
659:
577:
544:
460:
243:Protein kinase C
46:
34:
21:
5805:
5804:
5800:
5799:
5798:
5796:
5795:
5794:
5770:
5769:
5768:
5763:
5751:
5700:
5679:
5654:
5638:
5610:
5577:
5568:Arginine kinase
5556:
5513:
5472:
5265:
5261:Phospholipase C
5244:
5214:
5135:
5117:
5047:
5014:
5000:
4915:
4910:G alpha subunit
4901:
4857:
4789:
4763:
4744:
4739:
4709:
4696:
4644:
4622:
4546:
4529:
4512:
4495:
4466:
4326:
4226:
4197:P70-S6 Kinase 1
4167:
4058:
4020:
3998:
3964:
3940:
3901:
3867:
3573:
3544:
3520:
3501:
3422:
3398:
3359:
3315:
3298:
3274:
3268:Aurora C kinase
3263:Aurora B kinase
3258:Aurora A kinase
3238:
3219:
3185:
3156:
3089:
3055:
2911:
2897:
2883:
2853:
2844:
2815:
2793:
2768:
2739:
2733:
2729:2.7.10-2.7.13:
2720:
2704:
2671:: miscellaneous
2659:
2633:
2615:
2592:
2575:exoribonuclease
2572:
2560:
2546:Polyadenylation
2463:
2289:
2283:
2271:
2253:
2249:
2243:
2227:
2189:
2176:
2153:
2125:
1955:
1949:
1941:
1935:
1921:
1891:
1853:
1852:
1848:
1796:
1795:
1791:
1749:
1748:
1744:
1700:
1699:
1695:
1657:
1656:
1652:
1592:
1591:
1587:
1543:
1542:
1538:
1502:
1501:
1497:
1453:
1452:
1448:
1417:(52): 6059–64.
1404:
1403:
1399:
1362:Current Biology
1355:
1354:
1350:
1311:
1310:
1306:
1297:
1296:
1292:
1269:10.1038/ncb1236
1254:
1253:
1249:
1205:
1204:
1200:
1179:(5429): 895–8.
1169:
1168:
1164:
1126:
1125:
1121:
1077:
1076:
1069:
1038:(10): 5313–27.
1025:
1024:
1020:
997:10.1038/nrm1128
982:
981:
952:
900:
899:
888:
884:
872:
859:ROCK inhibitors
852:drug resistance
820:
814:
811:
804:needs expansion
789:
784:
778:
770:oligomerization
725:
458:
252:
203:and, thus, the
193:phosphorylation
185:focal adhesions
49:
32:
23:
22:
15:
12:
11:
5:
5803:
5801:
5793:
5792:
5787:
5782:
5772:
5771:
5765:
5764:
5756:
5753:
5752:
5750:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5708:
5706:
5702:
5701:
5699:
5698:
5689:
5687:
5681:
5680:
5678:
5677:
5668:
5666:
5660:
5659:
5656:
5655:
5653:
5652:
5646:
5644:
5640:
5639:
5637:
5636:
5631:
5621:
5619:
5612:
5611:
5609:
5608:
5602:
5600:
5590:
5583:
5582:
5579:
5578:
5576:
5575:
5570:
5564:
5562:
5558:
5557:
5555:
5554:
5553:
5552:
5547:
5542:
5537:
5532:
5521:
5519:
5515:
5514:
5512:
5511:
5506:
5505:
5504:
5499:
5489:
5483:
5481:
5474:
5473:
5471:
5470:
5469:
5468:
5458:
5457:
5456:
5451:
5441:
5440:
5439:
5434:
5429:
5424:
5414:
5413:
5412:
5407:
5397:
5396:
5395:
5390:
5385:
5380:
5370:
5369:
5368:
5363:
5358:
5348:
5347:
5346:
5341:
5336:
5331:
5326:
5316:
5315:
5314:
5304:
5303:
5302:
5297:
5286:
5284:
5274:
5272:protein kinase
5267:
5266:
5264:
5263:
5258:
5252:
5250:
5246:
5245:
5243:
5242:
5237:
5232:
5226:
5224:
5220:
5219:
5216:
5215:
5213:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5181:
5180:
5175:
5170:
5160:
5155:
5149:
5147:
5141:
5140:
5137:
5136:
5134:
5133:
5128:
5122:
5119:
5118:
5116:
5115:
5114:
5113:
5108:
5103:
5098:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5045:
5042:
5041:
5040:
5035:
5030:
5025:
5020:
5012:
5005:
5002:
5001:
4999:
4998:
4997:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4913:
4906:
4903:
4902:
4900:
4899:
4894:
4889:
4884:
4879:
4874:
4868:
4866:
4859:
4858:
4856:
4855:
4850:
4845:
4840:
4835:
4834:
4833:
4818:
4816:
4806:
4804:Heterotrimeric
4797:
4791:
4790:
4788:
4787:
4782:
4777:
4771:
4769:
4765:
4764:
4762:
4761:
4752:
4750:
4746:
4745:
4740:
4738:
4737:
4730:
4723:
4715:
4706:
4705:
4702:
4701:
4698:
4697:
4695:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4658:
4656:
4646:
4645:
4639:
4632:
4631:
4628:
4627:
4624:
4623:
4621:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4584:
4583:
4578:
4573:
4568:
4557:
4555:
4554:(EC 2.7.11.30)
4548:
4547:
4545:
4544:
4540:
4538:
4537:(EC 2.7.11.29)
4531:
4530:
4528:
4527:
4523:
4521:
4520:(EC 2.7.11.28)
4514:
4513:
4511:
4510:
4506:
4504:
4503:(EC 2.7.11.27)
4497:
4496:
4494:
4493:
4488:
4483:
4477:
4475:
4474:(EC 2.7.11.26)
4468:
4467:
4465:
4464:
4459:
4454:
4453:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4412:
4411:
4410:
4405:
4400:
4395:
4385:
4384:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4337:
4335:
4334:(EC 2.7.11.25)
4328:
4327:
4325:
4324:
4323:
4322:
4317:
4312:
4302:
4301:
4300:
4295:
4290:
4280:
4279:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4237:
4235:
4234:(EC 2.7.11.24)
4228:
4227:
4225:
4224:
4219:
4214:
4209:
4204:
4199:
4194:
4189:
4184:
4178:
4176:
4175:(EC 2.7.11.23)
4169:
4168:
4166:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4069:
4067:
4066:(EC 2.7.11.22)
4060:
4059:
4057:
4056:
4051:
4046:
4041:
4035:
4033:
4032:(EC 2.7.11.21)
4022:
4021:
4015:
4008:
4007:
4004:
4003:
4000:
3999:
3997:
3996:
3991:
3986:
3981:
3975:
3973:
3972:(EC 2.7.11.21)
3966:
3965:
3963:
3962:
3957:
3951:
3949:
3948:(EC 2.7.11.20)
3942:
3941:
3939:
3938:
3933:
3928:
3923:
3918:
3912:
3910:
3909:(EC 2.7.11.19)
3903:
3902:
3900:
3899:
3894:
3889:
3884:
3878:
3876:
3875:(EC 2.7.11.18)
3869:
3868:
3866:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3795:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3584:
3582:
3581:(EC 2.7.11.17)
3575:
3574:
3572:
3571:
3566:
3561:
3555:
3553:
3552:(EC 2.7.11.16)
3546:
3545:
3543:
3542:
3537:
3531:
3529:
3528:(EC 2.7.11.15)
3522:
3521:
3519:
3518:
3512:
3510:
3509:(EC 2.7.11.14)
3503:
3502:
3500:
3499:
3494:
3489:
3484:
3479:
3474:
3469:
3464:
3459:
3454:
3449:
3444:
3439:
3433:
3431:
3430:(EC 2.7.11.13)
3424:
3423:
3421:
3420:
3415:
3409:
3407:
3406:(EC 2.7.11.12)
3400:
3399:
3397:
3396:
3391:
3386:
3381:
3376:
3370:
3368:
3367:(EC 2.7.11.11)
3361:
3360:
3358:
3357:
3352:
3347:
3342:
3337:
3332:
3326:
3324:
3323:(EC 2.7.11.10)
3317:
3316:
3314:
3313:
3309:
3307:
3300:
3299:
3297:
3296:
3291:
3285:
3283:
3276:
3275:
3273:
3272:
3271:
3270:
3265:
3260:
3249:
3247:
3240:
3239:
3237:
3236:
3230:
3228:
3221:
3220:
3218:
3217:
3212:
3207:
3202:
3196:
3194:
3187:
3186:
3184:
3183:
3178:
3173:
3167:
3165:
3158:
3157:
3155:
3154:
3153:
3152:
3147:
3142:
3134:
3133:
3132:
3127:
3119:
3118:
3117:
3112:
3100:
3098:
3091:
3090:
3088:
3087:
3082:
3077:
3072:
3066:
3064:
3057:
3056:
3054:
3053:
3052:
3051:
3041:
3040:
3039:
3034:
3029:
3024:
3014:
3009:
3004:
3003:
3002:
2997:
2992:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2926:
2924:
2913:
2912:
2906:
2899:
2898:
2884:
2882:
2881:
2874:
2867:
2859:
2850:
2849:
2846:
2845:
2843:
2842:
2837:
2832:
2826:
2824:
2817:
2816:
2814:
2813:
2804:
2802:
2795:
2794:
2792:
2791:
2782:
2780:
2770:
2769:
2767:
2766:
2757:
2755:
2742:
2737:
2731:protein kinase
2726:
2725:
2722:
2721:
2719:
2718:
2712:
2710:
2706:
2705:
2703:
2702:
2697:
2692:
2687:
2681:
2679:
2672:
2665:
2664:
2661:
2660:
2658:
2657:
2652:
2641:
2639:
2635:
2634:
2632:
2631:
2625:
2623:
2617:
2616:
2614:
2613:
2608:
2602:
2600:
2594:
2593:
2591:
2590:
2585:
2579:
2577:
2570:Phosphorolytic
2566:
2565:
2562:
2561:
2559:
2558:
2553:
2548:
2543:
2538:
2537:
2536:
2531:
2526:
2516:
2515:
2514:
2504:
2499:
2494:
2489:
2484:
2479:
2473:
2471:
2469:RNA polymerase
2465:
2464:
2462:
2461:
2460:
2459:
2449:
2445:
2444:
2443:
2442:
2437:
2432:
2421:
2420:
2419:
2414:
2409:
2404:
2393:
2387:
2386:
2385:
2378:
2373:
2368:
2363:
2352:
2351:
2350:
2343:
2338:
2333:
2328:
2317:
2313:
2311:
2309:DNA polymerase
2302:
2293:
2287:
2273:
2272:
2270:
2269:
2264:
2258:
2256:
2251:
2247:
2233:
2232:
2229:
2228:
2226:
2225:
2220:
2215:
2210:
2205:
2200:
2194:
2192:
2187:
2178:
2177:
2175:
2174:
2168:
2166:
2155:
2154:
2152:
2151:
2146:
2140:
2138:
2127:
2126:
2124:
2123:
2118:
2113:
2112:
2111:
2106:
2096:
2094:Diacylglycerol
2091:
2086:
2081:
2076:
2071:
2066:
2061:
2056:
2055:
2054:
2044:
2039:
2034:
2033:
2032:
2027:
2022:
2017:
2012:
2005:Phosphofructo-
2002:
1997:
1996:
1995:
1985:
1980:
1974:
1972:
1958:
1953:
1937:
1936:
1922:
1920:
1919:
1912:
1905:
1897:
1890:
1889:
1846:
1809:(2): 299–310.
1803:Cancer Letters
1789:
1762:(2): 185–196.
1756:Cancer Letters
1742:
1693:
1666:(4): 455–462.
1650:
1585:
1536:
1495:
1466:(5): 1249–58.
1446:
1397:
1348:
1304:
1290:
1263:(4): 399–404.
1247:
1198:
1162:
1135:(3): 227–235.
1119:
1067:
1018:
950:
885:
883:
880:
879:
878:
871:
868:
822:
821:
801:
799:
788:
785:
777:
774:
768:, and protein
745:intramolecular
735:Autoinhibition
724:
721:
688:
687:
684:
683:
678:
674:
673:
668:
664:
663:
655:
654:
649:
643:
642:
637:
631:
630:
625:
619:
618:
613:
607:
606:
601:
595:
594:
591:
587:
586:
582:
581:
573:
572:
569:
568:
563:
559:
558:
553:
549:
548:
540:
539:
534:
528:
527:
522:
516:
515:
510:
504:
503:
498:
492:
491:
486:
480:
479:
474:
470:
469:
465:
464:
457:
454:
453:
452:
448:
445:
436:
435:
431:
419:
408:
401:
390:
358:
357:
356:
355:
348:
323:
322:
305:
304:
279:cell migration
251:
248:
155:molecular mass
101:
100:
95:
89:
88:
84:
83:
78:
72:
71:
68:
64:
63:
60:
56:
55:
51:
50:
47:
39:
38:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5802:
5791:
5788:
5786:
5783:
5781:
5778:
5777:
5775:
5762:
5761:
5754:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5709:
5707:
5703:
5697:
5696:
5691:
5690:
5688:
5686:
5682:
5676:
5675:
5670:
5669:
5667:
5665:
5661:
5651:
5648:
5647:
5645:
5641:
5635:
5632:
5630:
5626:
5623:
5622:
5620:
5617:
5613:
5607:
5604:
5603:
5601:
5598:
5594:
5591:
5589:
5584:
5574:
5571:
5569:
5566:
5565:
5563:
5559:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5527:
5526:
5523:
5522:
5520:
5516:
5510:
5507:
5503:
5500:
5498:
5495:
5494:
5493:
5490:
5488:
5485:
5484:
5482:
5479:
5475:
5467:
5464:
5463:
5462:
5459:
5455:
5452:
5450:
5447:
5446:
5445:
5442:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5419:
5418:
5415:
5411:
5408:
5406:
5403:
5402:
5401:
5398:
5394:
5391:
5389:
5386:
5384:
5381:
5379:
5376:
5375:
5374:
5371:
5367:
5364:
5362:
5359:
5357:
5354:
5353:
5352:
5349:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5321:
5320:
5317:
5313:
5310:
5309:
5308:
5305:
5301:
5298:
5296:
5293:
5292:
5291:
5290:Casein kinase
5288:
5287:
5285:
5282:
5278:
5275:
5273:
5268:
5262:
5259:
5257:
5254:
5253:
5251:
5247:
5241:
5238:
5236:
5233:
5231:
5228:
5227:
5225:
5221:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5179:
5176:
5174:
5171:
5169:
5166:
5165:
5164:
5161:
5159:
5156:
5154:
5151:
5150:
5148:
5146:
5142:
5132:
5129:
5127:
5124:
5123:
5120:
5112:
5109:
5107:
5104:
5102:
5099:
5097:
5094:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5048:
5043:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5015:
5010:
5007:
5006:
5003:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4916:
4911:
4908:
4907:
4904:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4869:
4867:
4864:
4860:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4832:
4828:
4825:
4824:
4823:
4820:
4819:
4817:
4814:
4810:
4807:
4805:
4801:
4798:
4796:
4792:
4786:
4783:
4781:
4778:
4776:
4773:
4772:
4770:
4766:
4760:
4759:
4754:
4753:
4751:
4747:
4743:
4736:
4731:
4729:
4724:
4722:
4717:
4716:
4713:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4659:
4657:
4655:
4651:
4647:
4642:
4637:
4633:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4563:
4562:
4559:
4558:
4556:
4553:
4549:
4542:
4541:
4539:
4536:
4532:
4525:
4524:
4522:
4519:
4515:
4508:
4507:
4505:
4502:
4498:
4492:
4489:
4487:
4484:
4482:
4479:
4478:
4476:
4473:
4469:
4463:
4460:
4458:
4455:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4417:
4416:
4413:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4390:
4389:
4386:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4343:
4342:
4339:
4338:
4336:
4333:
4329:
4321:
4318:
4316:
4313:
4311:
4308:
4307:
4306:
4303:
4299:
4296:
4294:
4291:
4289:
4286:
4285:
4284:
4281:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4243:
4242:
4239:
4238:
4236:
4233:
4229:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4179:
4177:
4174:
4170:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4070:
4068:
4065:
4061:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4036:
4034:
4031:
4027:
4023:
4018:
4013:
4009:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3976:
3974:
3971:
3967:
3961:
3958:
3956:
3953:
3952:
3950:
3947:
3943:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3913:
3911:
3908:
3904:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3879:
3877:
3874:
3870:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3585:
3583:
3580:
3576:
3570:
3567:
3565:
3562:
3560:
3557:
3556:
3554:
3551:
3547:
3541:
3538:
3536:
3533:
3532:
3530:
3527:
3523:
3517:
3514:
3513:
3511:
3508:
3504:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3434:
3432:
3429:
3425:
3419:
3416:
3414:
3411:
3410:
3408:
3405:
3401:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3371:
3369:
3366:
3362:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3327:
3325:
3322:
3318:
3311:
3310:
3308:
3306:(EC 2.7.11.9)
3305:
3301:
3295:
3292:
3290:
3287:
3286:
3284:
3282:(EC 2.7.11.8)
3281:
3277:
3269:
3266:
3264:
3261:
3259:
3256:
3255:
3254:
3253:Aurora kinase
3251:
3250:
3248:
3246:(EC 2.7.11.7)
3245:
3241:
3235:
3232:
3231:
3229:
3227:(EC 2.7.11.6)
3226:
3222:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3197:
3195:
3193:(EC 2.7.11.5)
3192:
3188:
3182:
3179:
3177:
3174:
3172:
3169:
3168:
3166:
3164:(EC 2.7.11.4)
3163:
3159:
3151:
3148:
3146:
3143:
3141:
3138:
3137:
3135:
3131:
3128:
3126:
3123:
3122:
3120:
3116:
3113:
3111:
3108:
3107:
3105:
3102:
3101:
3099:
3097:(EC 2.7.11.3)
3096:
3092:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3067:
3065:
3063:(EC 2.7.11.2)
3062:
3058:
3050:
3047:
3046:
3045:
3042:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3019:
3018:
3017:EIF-2 kinases
3015:
3013:
3010:
3008:
3005:
3001:
2998:
2996:
2993:
2991:
2988:
2987:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2927:
2925:
2923:(EC 2.7.11.1)
2922:
2918:
2914:
2909:
2904:
2900:
2895:
2891:
2887:
2880:
2875:
2873:
2868:
2866:
2861:
2860:
2857:
2841:
2838:
2836:
2833:
2831:
2828:
2827:
2825:
2822:
2818:
2812:
2811:
2806:
2805:
2803:
2800:
2796:
2790:
2789:
2784:
2783:
2781:
2779:
2775:
2771:
2765:
2764:
2759:
2758:
2756:
2754:
2750:
2746:
2743:
2740:
2732:
2727:
2717:
2714:
2713:
2711:
2707:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2682:
2680:
2676:
2673:
2670:
2666:
2656:
2653:
2650:
2646:
2643:
2642:
2640:
2636:
2630:
2627:
2626:
2624:
2622:
2618:
2612:
2609:
2607:
2604:
2603:
2601:
2599:
2595:
2589:
2586:
2584:
2581:
2580:
2578:
2576:
2571:
2567:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2535:
2532:
2530:
2527:
2525:
2522:
2521:
2520:
2517:
2513:
2510:
2509:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2474:
2472:
2470:
2466:
2458:
2455:
2454:
2453:
2450:
2447:
2446:
2441:
2438:
2436:
2433:
2431:
2428:
2427:
2425:
2422:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2399:
2397:
2394:
2391:
2388:
2384:
2383:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2362:
2359:
2358:
2356:
2353:
2349:
2348:
2344:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2323:
2321:
2318:
2315:
2314:
2312:
2310:
2306:
2303:
2301:
2297:
2294:
2291:
2282:
2278:
2274:
2268:
2265:
2263:
2260:
2259:
2257:
2254:
2242:
2238:
2234:
2224:
2221:
2219:
2216:
2214:
2211:
2209:
2206:
2204:
2201:
2199:
2196:
2195:
2193:
2190:
2183:
2179:
2173:
2170:
2169:
2167:
2164:
2160:
2156:
2150:
2147:
2145:
2142:
2141:
2139:
2136:
2132:
2128:
2122:
2119:
2117:
2114:
2110:
2109:Class II PI 3
2107:
2105:
2102:
2101:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2084:Deoxycytidine
2082:
2080:
2077:
2075:
2072:
2070:
2067:
2065:
2062:
2060:
2057:
2053:
2052:ADP-thymidine
2050:
2049:
2048:
2045:
2043:
2040:
2038:
2035:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2007:
2006:
2003:
2001:
1998:
1994:
1991:
1990:
1989:
1986:
1984:
1981:
1979:
1976:
1975:
1973:
1970:
1966:
1962:
1959:
1956:
1948:
1944:
1938:
1933:
1929:
1925:
1918:
1913:
1911:
1906:
1904:
1899:
1898:
1895:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1850:
1847:
1842:
1838:
1833:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1793:
1790:
1785:
1781:
1777:
1773:
1769:
1765:
1761:
1757:
1753:
1746:
1743:
1738:
1734:
1729:
1724:
1720:
1716:
1713:(4): 259–78.
1712:
1708:
1704:
1697:
1694:
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1654:
1651:
1646:
1642:
1638:
1634:
1629:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1589:
1586:
1581:
1577:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1540:
1537:
1532:
1528:
1523:
1518:
1514:
1510:
1506:
1499:
1496:
1491:
1487:
1482:
1477:
1473:
1469:
1465:
1461:
1457:
1450:
1447:
1442:
1438:
1434:
1430:
1425:
1420:
1416:
1412:
1408:
1401:
1398:
1393:
1389:
1385:
1381:
1376:
1371:
1367:
1363:
1359:
1352:
1349:
1344:
1340:
1336:
1332:
1328:
1324:
1321:(2): e49–61.
1320:
1316:
1308:
1305:
1300:
1294:
1291:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1251:
1248:
1243:
1239:
1234:
1229:
1225:
1221:
1218:(4): 531–40.
1217:
1213:
1209:
1202:
1199:
1194:
1190:
1186:
1182:
1178:
1174:
1166:
1163:
1158:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1123:
1120:
1115:
1111:
1107:
1103:
1098:
1093:
1090:(2): 189–93.
1089:
1085:
1081:
1074:
1072:
1068:
1063:
1059:
1054:
1049:
1045:
1041:
1037:
1033:
1029:
1022:
1019:
1014:
1010:
1006:
1002:
998:
994:
991:(6): 446–56.
990:
986:
979:
977:
975:
973:
971:
969:
967:
965:
963:
961:
959:
957:
955:
951:
946:
942:
938:
934:
929:
924:
920:
916:
912:
908:
904:
897:
895:
893:
891:
887:
881:
877:
874:
873:
869:
867:
864:
860:
855:
853:
849:
845:
841:
837:
833:
829:
818:
809:
805:
802:This section
800:
797:
793:
792:
786:
783:
775:
773:
771:
767:
763:
758:
757:
753:
750:
746:
741:
737:
736:
732:
730:
722:
720:
718:
714:
710:
705:
703:
699:
695:
682:
679:
675:
672:
669:
665:
660:
656:
653:
650:
648:
644:
641:
638:
636:
632:
629:
626:
624:
620:
617:
614:
612:
608:
605:
602:
600:
596:
592:
588:
583:
578:
567:
564:
560:
557:
554:
550:
545:
541:
538:
535:
533:
529:
526:
523:
521:
517:
514:
511:
509:
505:
502:
499:
497:
493:
490:
487:
485:
481:
478:
475:
471:
466:
461:
455:
449:
446:
443:
442:
441:
440:
432:
428:
424:
420:
417:
413:
409:
406:
402:
399:
395:
391:
388:
384:
380:
376:
375:
374:
373:
369:
367:
363:
362:stress fibers
353:
349:
346:
342:
338:
337:
336:
335:
334:
332:
328:
321:
318:
317:
316:
314:
310:
303:
300:
299:
298:
296:
292:
288:
283:
282:
280:
274:
272:
268:
265:
256:
249:
247:
244:
240:
238:
234:
230:
226:
222:
218:
214:
210:
206:
205:contractility
202:
198:
194:
190:
186:
182:
181:stress fibers
177:
175:
172:region and a
171:
167:
164:
160:
156:
152:
151:
146:
145:
140:
139:
134:
130:
125:
123:
119:
115:
111:
107:
99:
96:
94:
90:
85:
82:
79:
77:
73:
69:
65:
61:
57:
52:
45:
40:
35:
30:
19:
5757:
5692:
5671:
5443:
5307:eIF-2 kinase
4755:
4192:P70S6 kinase
2807:
2785:
2760:
2381:
2346:
2104:Class I PI 3
2069:Pantothenate
1940:2.7.1-2.7.4:
1924:Transferases
1859:
1855:
1849:
1806:
1802:
1792:
1759:
1755:
1745:
1710:
1706:
1696:
1663:
1659:
1653:
1605:(1): 47–62.
1602:
1598:
1588:
1553:
1549:
1539:
1512:
1508:
1498:
1463:
1459:
1449:
1414:
1410:
1400:
1368:(1): 12–23.
1365:
1361:
1351:
1318:
1314:
1307:
1293:
1260:
1256:
1250:
1215:
1211:
1201:
1176:
1172:
1165:
1132:
1128:
1122:
1087:
1084:FEBS Letters
1083:
1035:
1031:
1021:
988:
984:
913:(2): 171–7.
910:
906:
856:
825:
815:January 2020
812:
808:adding to it
803:
759:
755:
754:
742:
738:
734:
733:
726:
706:
691:
438:
437:
371:
370:
359:
324:
319:
306:
301:
284:
276:
275:
271:cytoskeleton
261:
241:
178:
157:of 158
148:
147:, mosquito,
142:
136:
126:
122:cytoskeleton
109:
105:
104:
67:Alt. symbols
4994:GNA15/GNA16
4780:Calcineurin
4643:(EC 2.7.12)
4030:Polo kinase
3970:Polo kinase
2655:Transposase
2645:Recombinase
2290:-nucleoside
2116:Sphingosine
671:Swiss-model
585:Identifiers
556:Swiss-model
468:Identifiers
427:growth cone
398:cytokinesis
383:phosphatase
352:phosphatase
327:contraction
313:ADF/cofilin
295:phosphatase
281:as follows:
199:binding of
170:coiled-coil
54:Identifiers
5780:Cell cycle
5774:Categories
5400:Lim kinase
5351:IκB kinase
4872:Transducin
3321:IκB kinase
2896:2.7.11-12)
2457:Telomerase
2300:Polymerase
2074:Mevalonate
2037:Riboflavin
1928:phosphorus
882:References
776:Inhibitors
729:Rho GTPase
723:Regulation
702:amino acid
667:Structures
662:Search for
552:Structures
547:Search for
456:Homologues
451:membrane).
394:centrioles
309:LIM kinase
150:Drosophila
144:C. elegans
87:Other data
18:Rho-kinase
5785:EC 2.7.11
5758:see also
5664:Apoptosis
5145:Monomeric
4877:Gustducin
4795:G protein
3447:PKC alpha
2649:Integrase
2573:3' to 5'
2218:Guanylate
2213:Uridylate
2203:Adenylate
2047:Thymidine
2042:Shikimate
1876:1520-4804
1823:0304-3835
1776:0304-3835
1680:1873-5592
1645:210043399
1619:1744-7631
762:activator
749:PH domain
640:NM_004850
599:NCBI gene
525:NM_005406
484:NCBI gene
430:collapse.
416:apoptosis
201:myosin II
93:EC number
76:NCBI gene
5616:Tyrosine
5561:Arginine
5478:Tyrosine
3803:KIAA0999
3698:MAPKAPK5
3693:MAPKAPK3
3688:MAPKAPK2
2583:RNase PH
2191:acceptor
2172:Creatine
2165:acceptor
2137:acceptor
2079:Pyruvate
2064:Glycerol
2025:Platelet
2000:Galacto-
1971:acceptor
1884:26486225
1841:25172415
1784:25796438
1737:26725045
1688:27033194
1637:31906742
1580:29057688
1531:12006612
1441:39115039
1433:11146558
1411:Oncogene
1392:16144917
1343:45342422
1335:15218323
1285:19316266
1277:15793569
1242:19131646
1193:10436159
1157:20486807
1149:29306925
1013:40665081
1005:12778124
937:19907920
928:11115778
870:See also
863:RKI-1447
861:such as
698:homology
681:InterPro
566:InterPro
366:integrin
250:Function
98:2.7.11.1
5742:EDARADD
5727:Mucin-4
5466:RPS6KA1
5312:EIF2AK3
4768:Calcium
4462:MAP3K14
4440:MAP3K11
4435:MAP3K10
4425:MAP3K13
4420:MAP3K12
4222:RPS6KC1
4217:RPS6KA1
4212:RPS6KA3
4207:RPS6KA2
4202:RPS6KB2
4187:RPS6KA4
4182:RPS6KA5
3833:Kalirin
3798:SNF1LK2
3037:EIF2AK4
3032:EIF2AK3
2886:Kinases
2534:PrimPol
2519:Primase
1993:Hepatic
1988:Fructo-
1832:4182185
1728:4930737
1628:7662835
1571:6221831
1490:9832553
1481:2133074
1384:8999996
1233:2649695
1173:Science
1114:6684411
1106:8772201
1062:8816443
945:6445354
787:Disease
677:Domains
647:UniProt
562:Domains
532:UniProt
423:neurite
405:insulin
138:Xenopus
127:ROCKs (
112:) is a
29:Rho Chi
5747:PRKCSH
5586:Other
5535:DYRK1B
5530:DYRK1A
5270:Other
5240:Cyclin
5223:Cyclin
4692:MAP2K7
4687:MAP2K6
4682:MAP2K5
4677:MAP2K4
4672:MAP2K3
4667:MAP2K2
4662:MAP2K1
4613:ACVRL1
4608:ACVR2B
4603:ACVR2A
4598:ACVR1C
4593:ACVR1B
4576:BMPR1B
4571:BMPR1A
4445:MAP3K7
4430:MAP3K9
4381:MAP3K8
4376:MAP3K7
4371:MAP3K6
4366:MAP3K5
4361:MAP3K4
4356:MAP3K3
4351:MAP3K2
4346:MAP3K1
4320:MAPK14
4315:MAPK13
4310:MAPK11
4298:MAPK10
4276:MAPK15
4271:MAPK12
4163:CDC2L1
4138:CDC2L5
3813:SNF1LK
3638:CAMK2G
3633:CAMK2D
3628:CAMK2B
3623:CAMK2A
3613:CAMK1G
3608:CAMK1D
3603:CAMK1B
3598:CAMK1A
3452:PRKCB1
3389:PRKACA
3384:PRKACB
3379:PRKACG
3355:IKBKAP
3181:BCKDHB
3176:BCKDHA
3150:PRKAG3
3145:PRKAG2
3140:PRKAG1
3130:PRKAB2
3125:PRKAB1
3115:PRKAA2
3110:PRKAA1
2955:STK38L
2821:2.7.13
2799:2.7.12
2774:2.7.11
2749:2.7.10
2588:PNPase
2556:PNPase
2512:POLRMT
2507:ssRNAP
2020:Muscle
1983:Gluco-
1947:kinase
1882:
1874:
1839:
1829:
1821:
1782:
1774:
1735:
1725:
1686:
1678:
1643:
1635:
1625:
1617:
1578:
1568:
1529:
1488:
1478:
1439:
1431:
1390:
1382:
1341:
1333:
1283:
1275:
1240:
1230:
1191:
1155:
1147:
1112:
1104:
1060:
1053:231530
1050:
1011:
1003:
943:
935:
925:
844:cancer
842:, and
838:, and
717:motifs
652:O75116
635:RefSeq
628:604002
590:Symbol
537:Q13464
520:RefSeq
513:601702
473:Symbol
345:ATPase
331:myosin
291:myosin
287:kinase
264:GTPase
229:testis
225:kidney
221:spleen
195:, the
163:GTPase
114:kinase
81:579202
59:Symbol
5705:Other
5643:both:
5550:DYRK4
5545:DYRK3
5540:DYRK2
5502:PTK2B
5487:ZAP70
5454:ROCK2
5449:ROCK1
5410:LIMK2
5405:LIMK1
5393:IRAK4
5388:IRAK3
5383:IRAK2
5378:IRAK1
5366:IKBKG
5344:GSK3B
5339:GSK3A
5334:GSK-3
5249:Lipid
5200:Rhebs
5111:BSCL2
5106:GNG13
5101:GNG12
5096:GNG11
5091:GNG10
5056:GNGT2
5051:GNGT1
4989:GNA14
4984:GNA13
4979:GNA12
4974:GNA11
4949:GNAT3
4944:GNAT2
4939:GNAT1
4934:GNAI3
4929:GNAI2
4924:GNAI1
4919:GNAO1
4654:MAP2K
4588:ACVR1
4581:BMPR2
4566:BMPR1
4491:GSK-3
4332:MAP3K
4293:MAPK9
4288:MAPK8
4266:MAPK7
4261:MAPK6
4256:MAPK4
4251:MAPK3
4246:MAPK1
4158:PFTK1
4153:PCTK3
4148:PCTK2
4143:PCTK1
4133:CDK12
4128:CDK10
4103:CDKL5
4083:CDKL2
3960:STK19
3955:EEF2K
3936:PHKG2
3931:PHKG1
3921:PHKA2
3916:PHKA1
3897:MYLK4
3892:MYLK3
3887:MYLK2
3863:DCLK1
3858:Titin
3848:TRIB3
3843:TRIB2
3838:TRIB1
3828:TSSK2
3808:STK40
3793:PSKH1
3788:PRKD3
3783:PRKD2
3763:PHKG2
3758:PHKG1
3748:OBSCN
3743:NUAK2
3738:NUAK1
3733:MKNK2
3728:MKNK1
3718:MARK4
3713:MARK3
3708:MARK2
3703:MARK1
3683:STK11
3678:DAPK3
3673:DAPK2
3668:DAPK1
3663:CHEK2
3658:CHEK1
3643:CAMK4
3618:CAMK2
3593:CAMK1
3588:BRSK2
3482:PRKCQ
3477:PRKCI
3472:PRKCG
3467:PRKCH
3462:PRKCE
3457:PRKCD
3418:PRKG1
3350:IKBKG
3345:IKBKE
3294:STK10
3289:FASTK
3215:IDH3G
3210:IDH3B
3205:IDH3A
3171:BCKDK
2965:ROCK1
2950:STK38
2945:MAST2
2940:MAST1
2935:LATS2
2930:LATS1
2669:2.7.8
2638:Other
2277:2.7.7
2237:2.7.6
2182:2.7.4
2159:2.7.3
2131:2.7.2
2015:Liver
1978:Hexo-
1965:2.7.1
1641:S2CID
1437:S2CID
1388:S2CID
1339:S2CID
1281:S2CID
1153:S2CID
1110:S2CID
1009:S2CID
941:S2CID
876:ROCK1
713:Cdc42
694:ROCK1
616:10252
593:ROCK2
501:10251
477:ROCK1
387:tumor
237:heart
233:brain
217:liver
209:ROCK1
197:actin
133:ROCK2
129:ROCK1
5693:see
5672:see
5573:McsB
5497:PTK2
5437:PAK4
5432:PAK3
5427:PAK2
5422:PAK1
5361:IKK2
5356:CHUK
5329:GSK2
5324:GSK1
5210:RGKs
5205:Raps
5190:Arfs
5185:Rhos
5178:NRAS
5173:KRAS
5168:HRAS
5158:Rabs
5153:ARFs
5086:GNG8
5081:GNG7
5076:GNG5
5071:GNG4
5066:GNG3
5061:GNG2
5038:GNB5
5033:GNB4
5028:GNB3
5023:GNB2
5018:GNB1
4969:GNAQ
4964:GNAL
4959:GNAS
4954:GNAZ
4887:cGMP
4863:cGMP
4843:cAMP
4813:cAMP
4756:see
4481:TPK1
4457:CDC7
4415:MLKs
4408:KSR2
4403:KSR1
4398:BRAF
4393:ARAF
4388:RAFs
4123:CDK9
4118:CDK8
4113:CDK7
4108:CDK6
4098:CDK5
4093:CDK4
4088:CDK3
4078:CDK2
4073:CDK1
4054:PLK4
4049:PLK3
4044:PLK2
4039:PLK1
3994:PLK4
3989:PLK3
3984:PLK2
3979:PLK1
3926:PHKB
3882:MYLK
3853:TRIO
3823:SPEG
3818:SNRK
3778:PKD1
3773:PIM2
3768:PIM1
3753:PASK
3723:MELK
3653:CASK
3648:MLCK
3569:GRK6
3564:GRK5
3559:GRK4
3497:PKN3
3492:PKN2
3394:PRKY
3340:TBK1
3335:IKK2
3330:CHUK
3234:STK4
3200:IDH2
3085:PDK4
3080:PDK3
3075:PDK2
3070:PDK1
3049:WEE1
3044:Wee1
3012:mTOR
3000:AKT3
2995:AKT2
2990:AKT1
2980:SGK3
2975:SGK2
2808:see
2786:see
2761:see
2135:COOH
1934:2.7)
1880:PMID
1872:ISSN
1837:PMID
1819:ISSN
1780:PMID
1772:ISSN
1733:PMID
1684:PMID
1676:ISSN
1633:PMID
1615:ISSN
1576:PMID
1527:PMID
1486:PMID
1429:PMID
1380:PMID
1331:PMID
1273:PMID
1238:PMID
1189:PMID
1145:PMID
1102:PMID
1058:PMID
1001:PMID
933:PMID
854:).
709:DMPK
623:OMIM
611:HGNC
604:9475
508:OMIM
496:HGNC
489:6093
379:PTEN
235:and
227:and
213:lung
183:and
166:RhoA
131:and
110:ROCK
37:ROCK
5509:BTK
5195:Ran
5163:Ras
4749:MAP
4486:TTK
4450:ZAK
3027:HRI
3022:PKR
2970:SGK
2960:CIT
2551:PAP
2492:III
2426:/Y
2417:TDT
2398:/X
2390:III
2382:Pfu
2357:/B
2347:Taq
2322:/A
2089:PFP
2059:NAD
1864:doi
1827:PMC
1811:doi
1807:354
1764:doi
1760:361
1723:PMC
1715:doi
1668:doi
1623:PMC
1607:doi
1566:PMC
1558:doi
1517:doi
1513:115
1476:PMC
1468:doi
1464:143
1419:doi
1370:doi
1323:doi
1265:doi
1228:PMC
1220:doi
1216:104
1181:doi
1177:285
1137:doi
1092:doi
1088:392
1048:PMC
1040:doi
993:doi
923:PMC
915:doi
810:.
341:MLC
267:Rho
189:MLC
159:kDa
5776::
5627::
4831:Gi
4827:Gs
3136:γ
3121:β
3106:α
2894:EC
2888::
2776::
2751::
2736:PO
2497:IV
2487:II
2396:IV
2392:/C
2355:II
2341:T7
2286:PO
2279::
2239::
2186:PO
2184::
2161::
2133::
1969:OH
1967::
1952:PO
1932:EC
1926::
1878:.
1870:.
1860:59
1858:.
1835:.
1825:.
1817:.
1805:.
1801:.
1778:.
1770:.
1758:.
1754:.
1731:.
1721:.
1711:64
1709:.
1705:.
1682:.
1674:.
1664:18
1662:.
1639:.
1631:.
1621:.
1613:.
1603:24
1601:.
1597:.
1574:.
1564:.
1554:17
1552:.
1548:.
1525:.
1511:.
1507:.
1484:.
1474:.
1462:.
1458:.
1435:.
1427:.
1415:19
1413:.
1409:.
1386:.
1378:.
1364:.
1360:.
1337:.
1329:.
1319:97
1317:.
1279:.
1271:.
1259:.
1236:.
1226:.
1214:.
1210:.
1187:.
1175:.
1151:.
1143:.
1133:29
1131:.
1108:.
1100:.
1086:.
1082:.
1070:^
1056:.
1046:.
1036:16
1034:.
1030:.
1007:.
999:.
987:.
953:^
939:.
931:.
921:.
911:67
909:.
905:.
889:^
834:,
289:,
273:.
239:.
223:,
219:,
215:,
124:.
5618::
5599::
5480::
5300:2
5295:1
5283::
5046:γ
5044:G
5013:β
5011:G
4914:α
4912:G
4865::
4829:/
4815::
4734:e
4727:t
4720:v
4543:-
4526:-
4509:-
3312:-
2892:(
2878:e
2871:t
2864:v
2738:4
2734:(
2651:)
2647:(
2529:2
2524:1
2502:V
2440:κ
2435:ι
2430:η
2424:V
2412:μ
2407:λ
2402:β
2376:ζ
2371:ε
2366:δ
2361:α
2336:ν
2331:θ
2326:γ
2320:I
2292:)
2288:4
2284:(
2255:)
2252:7
2250:O
2248:2
2246:P
2244:(
2188:4
2163:N
2030:2
2010:1
1957:)
1954:4
1950:(
1945:/
1916:e
1909:t
1902:v
1886:.
1866::
1843:.
1813::
1786:.
1766::
1739:.
1717::
1690:.
1670::
1647:.
1609::
1582:.
1560::
1533:.
1519::
1492:.
1470::
1443:.
1421::
1394:.
1372::
1366:7
1345:.
1325::
1301:.
1287:.
1267::
1261:7
1244:.
1222::
1195:.
1183::
1159:.
1139::
1116:.
1094::
1064:.
1042::
1015:.
995::
989:4
947:.
917::
817:)
813:(
400:.
381:(
108:(
31:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
