30:
246:
255:
395:. During 1988-1990, Ryszard Andruszkiewicz, a visiting research fellow, synthesized a series of molecules for Silverman. One looked promising. The molecule was transported into the brain, where it activated the enzyme L-glutamate decarboxylase. Silverman anticipated that the enzyme would increase production of the inhibitory neurotransmitter
337:
Silverman has been teaching and doing research at
Northwestern since 1976. He became both professor of chemistry and professor of biochemistry, molecular biology, and cell biology in 1986. He has held several named professorships. He was the Arthur Andersen Professor of Chemistry from 1988 to 1996,
418:
Research has shown that the mechanism of the drug is more complicated than originally anticipated. In addition to its effects on GABA-AT substrate behavior, pregabalin binds to calcium channels and blocks glutamate release. GABA is potentiated, but through a different mechanism than originally
633:
Lyrica royalties paid to
Northwestern, and a gift from Silverman himself, have supported the Silverman Hall for Molecular Therapeutics and Diagnostics at Northwestern University. Silverman Hall, which opened in 2009, was designed to be a collaborative and interdisciplinary facility housing
1447:"The 2011 E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances: (1,3)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a GABA Aminotransferase Inactivator and New Treatment for Drug Addiction and Infantile Spasms"
338:
the
Charles Deering McCormick Professor of Teaching Excellence from 2001 to 2003, and the John Evans Professor of Chemistry beginning from 2004 to 2015. He was named the inaugural Patrick G. Ryan/Aon Professor as of September 1, 2015.
1196:
Taylor, CP; Angelotti, T; Fauman, E (February 2007). "Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery".
173:
1131:
399:
and block convulsions. Eventually, the set of molecules were sent to Parke-Davis
Pharmaceuticals for testing. In addition to treating seizures, pregabalin was found to be effective in treating
1619:
440:
1698:
369:). He has developed novel approaches to the elucidation of enzyme-catalyzed reactions in organic chemistry. He is interested in understanding and developing mechanisms of
988:
1688:
1297:
165:
1323:
1139:
1703:
1497:
1593:
1678:
133:
1673:
281:. His group's main focus is basic and translational research into central nervous system disorders and cancer. He is known for the discovery of
464:
314:
1395:
388:(Academic Press; 2000, 2002; see the Published works section, below). He is active on the editorial boards of a number of scholarly journals.
1693:
1034:
532:
2011 E.B. Hershberg Award for important discoveries in medicinally active substances from the
American Chemical Society for the discovery of
141:
1365:
376:
Silverman has published about 400 research articles. He has been awarded 130 patents. He has written 3 books (one in the third edition):
527:
1683:
748:
660:
298:
895:
1070:
863:
317:
from
January 1969 until his honorable discharge in January 1971. In June 1974, he received his Ph.D. from Harvard University in
996:
804:
776:
718:
690:
434:
342:
1522:
1298:"Three Professors Named National Academy of Inventors Fellows Inventors have demonstrated a "prolific spirit of innovation"
581:
511:
497:
458:
346:
302:
262:
149:
75:
1647:
470:
408:
29:
539:
1259:
490:
452:
596:
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575:
554:
446:
117:
366:
565:
2014 first recipient of the
Northwestern University Trustee Medal for Faculty Innovation and Entrepreneurship
560:
841:
278:
214:
1161:
Silverman, Richard B. (April 28, 2008). "From Basic
Science to Blockbuster Drug: The Discovery of Lyrica".
1663:
545:
354:
350:
1620:"Northwestern University Richard and Barbara Silverman Hall for Molecular Therapeutics and Diagnostics"
1547:
607:
Silverman has received numerous teaching awards from
Northwestern University, including the following:
1668:
1349:"American Academy of Arts and Sciences; 2014 FELLOWS AND THEIR AFFILIATIONS AT THE TIME OF ELECTION"
569:
924:
326:
1222:
392:
310:
306:
82:
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686:
656:
370:
318:
157:
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1206:
1170:
1099:
404:
245:
221:
181:
1498:"Dr. Richard Silverman Awarded by American Chemical Society and Royal Society of Chemistry"
1348:
1241:
1088:"4-Amino-3-alkylbutanoic acids as substrates for gamma-aminobutyric acid aminotransferase"
899:
615:
125:
614:
1999 Excellence in
Chemistry Education Award from the Northwestern University chapter of
325:. He then spent two years as a postdoctoral fellow with Robert Abeles in biochemistry at
1568:
1420:
523:
2009 inductee into the Medicinal Chemistry Hall of Fame of the American Chemical Society
1471:
1446:
504:
1260:"2011 ACS Fellows Society honors 213 members in the third year of its fellows program"
1104:
1087:
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1210:
322:
1226:
517:
400:
109:
56:
794:
766:
738:
708:
680:
650:
391:
Silverman is known for inventing the drug pregabalin as a possible treatment for
1024:
1594:"Silverman Receives Trustee Medal for Faculty Innovation and Entrepreneurship"
1275:
282:
258:
95:
274:
204:
1480:
1218:
1182:
1174:
952:
586:
2021 Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry
1113:
836:
362:
358:
533:
1462:
483:
412:
286:
624:
2001-2004 Charles Deering McCormick Professor of Teaching Excellence
595:
2024 Abeles and Jencks Award for Chemistry of Biological Processes,
341:
The primary focus in Silverman's laboratory is basic research into
1421:"Richard B Silverman, Creator of Lyrica, to Receive Perkin Medal"
1132:"Polish scientist is the co-author of a new anti-epileptic drug"
1029:. Washington, D.C.: National Academies Press. pp. 172–173.
1026:
Building the Illinois innovation economy. summary of a symposium
396:
1324:"Three attend American Academy of Arts and Sciences ceremony"
652:
Mechanism-Based Enzyme Inactivation: Chemistry and Enzymology
520:
from the American section of the Society of Chemical Industry
378:
Mechanism-Based Enzyme Inactivation: Chemistry and Enzymology
771:(2nd ed.). San Diego, Calif.: Elsevier/Academic Press.
273:(born May 12, 1946) is the Patrick G. Ryan/Aon Professor of
174:
Abeles and Jencks Award in Chemistry of Biological Processes
553:
2013 Bristol-Myers Squibb-Edward E. Smissman Award of the
589:
2024 Esselen Award for Chemistry in the Public Interest,
259:"Richard B. Silverman, Basic Science to Blockbuster Drug"
415:(which bought Parke-Davis) under the trade name Lyrica.
1086:
Andruszkiewicz, R; Silverman, RB (December 25, 1990).
989:"Silverman's golden drug makes him NU's golden ticket"
634:
researchers from chemistry, biology, and engineering.
550:
2013 Centenary Prize of the Royal Society of Chemistry
1065:. Amsterdam: Elsevier/Academic Press. pp. 331–.
743:(3rd ed.). San Diego, Calif.: Elsevier Science.
411:. It was approved by the FDA in 2004 and marketed by
796:
The Organic Chemistry of Drug Design and Drug Action
768:
The Organic Chemistry of Drug Design and Drug Action
740:
The Organic Chemistry of Drug Design and Drug Action
621:
2000 Alumni Association Excellence in Teaching Award
1569:"The ICS Barry Cohen Prize for medicinal chemistry"
799:(1st ed.). San Diego, Calif.: Academic Press.
713:(1st ed.). San Diego, Calif.: Academic Press.
710:
The Organic Chemistry of Enzyme-Catalyzed Reactions
685:(2nd ed.). San Diego, Calif.: Academic Press.
682:
The Organic Chemistry of Enzyme-Catalyzed Reactions
441:
American Association for the Advancement of Science
238:
220:
210:
200:
102:
91:
71:
63:
39:
20:
737:Silverman, Richard B.; Holladay, Mark W. (2014) .
182:Esselen Award for Chemistry in the Public Interest
837:"Health Blog: Lyrica Makes Rain at Northwestern"
611:1999 E. LeRoy Hall Award for Teaching Excellence
382:Organic Chemistry of Drug Design and Drug Action
301:. Silverman received his B.S. in chemistry from
386:Organic Chemistry of Enzyme-Catalyzed Reactions
559:2014 Excellence in Medicinal Chemistry Prize,
538:2012 Sato Memorial International Award of the
526:2011 inductee into the Alumni Hall of Fame of
507:Scholar Award of the American Chemical Society
1492:
1490:
8:
864:"Dedication of the Silverman Faculty Lounge"
655:(1st ed.). Boca Raton, Fl.: CRC Press.
1555:T he Medicinal Chemistry Section of the ICS
873:. Central High School of Philadelphia. 2014
1445:Silverman, Richard B. (January 26, 2012).
1063:Contemporary enzyme kinetics and mechanism
28:
17:
1699:Central High School (Philadelphia) alumni
1470:
1103:
1018:
1016:
1014:
982:
980:
978:
976:
974:
972:
925:"iCON Innovator Award (University Level)"
1689:Fellows of the American Chemical Society
1600:. Northwestern University. June 17, 2014
1125:
1123:
384:(Academic Press; 1992, 2004, 2014), and
1163:Angewandte Chemie International Edition
827:
465:American Academy of Arts & Sciences
361:. Other research areas include cancer (
947:
945:
919:
917:
315:Walter Reed Army Institute of Research
309:before being drafted and serving as a
235:
1059:"Mechanism-based enzyme inactivators"
34:Richard Silverman, Perkin Award, 2009
7:
1296:Fellman, Megan (December 17, 2014).
890:
888:
1322:Fellman, Megan (October 29, 2014).
1092:The Journal of Biological Chemistry
987:Merrill, Nick (February 25, 2010).
956:ACS Division of Medicinal Chemistry
574:2017 Award for Creative Invention,
528:Central High School of Philadelphia
313:Physical Sciences Assistant at the
299:Central High School of Philadelphia
580:2017 Distinguished Alumnus Award,
510:2008 Alumni Fellow Award from the
305:in 1968. He spent one semester at
14:
1136:Science and Scholarship in Poland
835:Francis, Theo (August 17, 2007).
568:2014 iCON Innovator Award of the
500:Research Career Development award
1704:Eberly College of Science alumni
1211:10.1016/j.eplepsyres.2006.09.008
544:2013 Roland T. Lakey Award from
343:central nervous system disorders
253:
244:
1679:Northwestern University faculty
1396:"Arthur C. Cope Scholar Awards"
1264:Chemical & Engineering News
793:Silverman, Richard B. (1992) .
765:Silverman, Richard B. (2004) .
707:Silverman, Richard B. (2000) .
679:Silverman, Richard B. (2002) .
649:Silverman, Richard B. (1988) .
540:Pharmaceutical Society of Japan
1674:21st-century American chemists
1451:Journal of Medicinal Chemistry
1246:Science Translational Medicine
1240:Lowe, Derek (March 25, 2008).
1061:. In Purich, Daniel L. (ed.).
1057:Silverman, Richard B. (2009).
435:American Institute of Chemists
1:
1548:"2014 MCS - ICS Award Letter"
1523:"Centenary Prize 2013 Winner"
1270:(32): 58–60. August 8, 2011.
1105:10.1016/S0021-9258(18)45702-X
953:"Richard B. Silverman, Ph.D."
582:Pennsylvania State University
512:Pennsylvania State University
498:National Institutes of Health
459:National Academy of Inventors
347:Amyotrophic lateral sclerosis
303:Pennsylvania State University
289:under the brand name Lyrica.
263:National Academy of Inventors
76:Pennsylvania State University
1694:Scientists from Philadelphia
1023:Wessner, Charles W. (2013).
471:National Academy of Sciences
409:generalized anxiety disorder
1573:The Israel Chemical Society
1720:
1650:at Northwestern University
1527:Royal Society of Chemistry
1370:Alfred P. Sloan Foundation
491:Alfred P. Sloan Foundation
453:Royal Society of Chemistry
1684:Harvard University alumni
1400:American Chemical Society
1276:10.1021/cen-v089n032.p058
597:American Chemical Society
591:American Chemical Society
576:American Chemical Society
555:American Chemical Society
447:American Chemical Society
252:
243:
230:
193:
27:
367:hepatocellular carcinoma
1502:Northwestern University
842:The Wall Street Journal
561:Israel Chemical Society
285:, which is marketed by
279:Northwestern University
271:Richard Bruce Silverman
215:Northwestern University
22:Richard Bruce Silverman
1175:10.1002/anie.200704280
1130:Poros, Joanna (2005).
546:Wayne State University
993:North by Northwestern
618:Chemistry Fraternity
486:Young Faculty Fellow
469:2023 Elected to the
463:2014 Elected to the
1376:on November 6, 2016
1242:"Getting To Lyrica"
457:2014 Fellow of the
451:2013 Fellow of the
445:2011 Fellow of the
439:1990 Fellow of the
433:1985 Fellow of the
380:(CRC Press; 1988),
355:Alzheimer's disease
351:Parkinson's disease
327:Brandeis University
297:Silverman attended
98:(brand name Lyrica)
1624:Thornton Tomasetti
1142:on August 20, 2016
896:"Curriculum Vitae"
871:The Alumni Journal
393:epileptic seizures
311:United States Army
307:Harvard University
83:Harvard University
1648:Richard Silverman
1557:. April 10, 2014.
1463:10.1021/jm201650r
1328:Northwestern News
1302:Northwestern News
1199:Epilepsy Research
1169:(19): 3500–3504.
1036:978-0-309-27869-0
423:Awards and honors
371:enzyme inhibition
319:organic chemistry
268:
267:
234:
233:
195:Scientific career
158:Tetrahedron Prize
87:
80:
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1431:
1417:
1411:
1410:
1408:
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1392:
1386:
1385:
1383:
1381:
1372:. Archived from
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1237:
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1138:. Archived from
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1098:(36): 22288–91.
1083:
1077:
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1054:
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1047:
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1043:
1020:
1009:
1008:
1006:
1004:
995:. Archived from
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967:
966:
964:
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949:
940:
939:
937:
935:
921:
912:
911:
909:
907:
898:. Archived from
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851:
849:
832:
817:
815:
813:
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703:
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669:
405:neuropathic pain
257:
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222:Doctoral advisor
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85:
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57:Philadelphia, PA
53:
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32:
18:
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1364:
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1257:
1253:
1239:
1238:
1234:
1195:
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1190:
1160:
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1080:
1073:
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1041:
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1037:
1022:
1021:
1012:
1002:
1000:
999:on June 1, 2016
986:
985:
970:
960:
958:
951:
950:
943:
933:
931:
923:
922:
915:
905:
903:
902:on May 15, 2008
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695:
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678:
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663:
648:
645:
640:
638:Published works
631:
616:Alpha Chi Sigma
605:
603:Teaching awards
479:
430:
425:
335:
295:
254:
239:External videos
189:
184:
176:
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136:
128:
126:Centenary Prize
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81:
72:Alma mater
59:
54:
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43:
35:
23:
12:
11:
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1643:
1642:External links
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1514:
1486:
1457:(2): 567–575.
1437:
1412:
1387:
1366:"Past Fellows"
1357:
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1232:
1188:
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929:IBIO Institute
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750:978-0123820303
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570:iBIO Institute
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505:Arthur C. Cope
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477:Medals, Prizes
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110:Perkin Medal
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1669:1946 births
1425:SCI America
812:February 5,
784:February 5,
756:February 5,
726:February 5,
698:February 5,
668:February 5,
428:Memberships
419:suspected.
166:Member, NAS
150:Fellow, NAI
134:Fellow, RSC
118:Fellow, ACS
64:Nationality
1658:Categories
1598:The Garage
822:References
806:0126437300
778:0126437327
720:0126437459
692:0126437319
496:1982-1987
283:pregabalin
96:Pregabalin
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848:April 17,
293:Education
275:Chemistry
205:Chemistry
1481:22168767
1227:54254671
1219:17126531
1183:18307181
363:melanoma
359:epilepsy
333:Research
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1629:May 19,
1604:May 20,
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1472:3266980
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287:Pfizer
201:Fields
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169:(2023)
161:(2021)
153:(2014)
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129:(2013)
121:(2011)
113:(2009)
103:Awards
79:(B.S.)
1551:(PDF)
1352:(PDF)
1223:S2CID
867:(PDF)
643:Books
516:2009
503:2003
489:1981
482:1976
1631:2016
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1477:PMID
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