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is especially known for his work on fluorescence and his studies on thalidomide in which he has shown that none of the twelve breakdown products which he identified is teratogenic. Williams has also defined the structural factors required for a compound to be excreted through the bile. He has discovered species differences which may have an application in primate classification. His work is of immediate relevance to an understanding of drug metabolism and action and that of the biological effects of food additives, pesticides, and other compounds foreign to the body".
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The researches of
Williams have been largely responsible for laying the foundations of biochemical toxicology. He has worked on the metabolism of aliphatic alcohols, alicyclic hydrocarbons, benzenes and alkylbenzenes, sulphonamides, drugs of a wide variety, heterocycles, and organotin compounds. He
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as a visiting scientist, where he became interested in spectrophotofluorimetry and the work of Robert Bowman. He returned with a spectrophotofluorimeter, for several years the only one in the UK, and used it for elucidating the relation between chemical structure and fluorescence. His hope that the
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While a research student at
Cardiff, Tecwyn Williams met Josephine Teresa Sullivan, who had been apprenticed and indentured as a ladies and gentlemen’s tailor. They married in 1937, and had five children: Peter Sullivan, Richard Stephen Steel, Josephine Mary Johnston, Helen Maria Tecwyn and Marian
251:
a former student of
Williams at Liverpool. The two worked with the Inter-University Council for Higher Education Overseas to form the link, which allowed the exchange of teaching staff and the development of joint research programmes, and through which Williams developed an undergraduate teaching
197:, Wales, the first of five children of Richard Williams, a coalminer, and Mary Ellen (née Jones), a teacher. He grew up speaking Welsh and English. His initial schooling was at Gelli Crug Junior School, from where he gained a scholarship to Abertillery County School. This was followed by
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in 1934. Here, Williams further developed his ideas concerning the metabolism of foreign compounds. His 1938 paper on detoxication of phenol in the rabbit proved to be the first in a series, culminating in Part 77 twenty years later. He was awarded a DSc at
Birmingham in 1939.
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228:, which revealed the formation of the hydroxylamine derivative, 2,6-dinitro-4-hydroxylaminotoluene, a highly toxic substance, which probably accounted for the toxicity of TNT itself.
208:. This work formed part of his PhD thesis; he was awarded the degree in 1932. After postdoctoral research at Cardiff he was appointed Lecturer in Biochemistry at the
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An opportunity arose for
Williams to undertake research with Dr John Pryde at the Physiology Institute, Cardiff, where he worked on elucidating the structure of
670:"Studies in detoxication. Part 1. The influence of (a) dose and (b) o-, m- and p-substitution on the ethereal sulphate detoxication of phenol in the rabbit"
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Williams had a particular interest in
Nigeria and in 1968 a link was established between St Mary's and the Department of Biochemistry,
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technique would become widespread and important was not fulfilled: gas chromatography was to become universally much more useful.
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945:"DENNIS V. PARKE, PhD, DSc, FRSC, FRCPath, FIBiol, Hon.FRCP, Doctor Honoris Causa, Medical University of Łódź, 1922-2002".
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In
January 1949, aged 39, Tecwyn Williams took up a new appointment, as the first Chair of Biochemistry at
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596:"The biochemistry and physiology of glucuronic acid: The structure of glucuronic acid of animal origin"
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Neuberger, A.; Smith, R. L. (1983). "Richard Tecwyn
Williams: The Man, His Work, His Impact".
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Dr Robert Smith - Professor of
Biochemical Pharmacology, St Mary’s Hospital Medical School
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where he studied chemistry and physiology, and was awarded a BSc in 1928.
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History of
Xenobiotic Metabolism: R.T.Williams:The Founding of the Field
397:"Obituary: Richard Tecwyn Williams, 20 February 1909 - 29 December 1979"
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Dr Dennis Parke - Professor and head of the Department of Biochemistry,
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International Journal of Occupational Medicine and Environmental Health
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In 1942, Williams was appointed Senior Lecturer in Biochemistry in the
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programme in drug metabolism. He was awarded a DSc by Ibadan in 1974.
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in 1947. This seminal book built on his earlier work on the role of
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Dr Olumbe Bassir - Professor of Biochemistry, University of Ibadan
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A portrait of Richard Tecwyn Williams can be found on page 1 of
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Dr Donald Davies - Professor of Biochemical Pharmacology,
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Creaven, P J C; Parke, D V; Williams, R T (August 1965).
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McIsaac, W M; Parke, D V; Williams, R T (December 1958).
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Channon, H J; Mills, G T; Williams, R T (January 1944).
768:"The Metabolism of 2:4:6-trinitrotoluene (α-T.N.T.)"
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Biographical Memoirs of Fellows of the Royal Society
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984:International Society for the Study of Xenobiotics
395:Neunerger, Albert; Smith, R L (1 November 1982).
235:. During this phase of his career he visited the
259:in March 1967. His application citation read: "
247:. The Professor of Biochemistry at Ibadan was
644:"Celli Crug - Boys, Girls and Infants School"
343:Dr John Smith - Chair of Biochemistry at the
19:For other people named Richard Williams, see
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918:(online ed.). Oxford University Press.
361:Dr Donald Robinson - Chair of Biochemistry,
162:(20 February 1909 – 29 December 1979) was a
1028:Alumni of St Mary's Hospital Medical School
971:, J.Wiley & Sons, New York, N.Y. (1947)
816:"Biographies: Robert L. Bowman (1916-1995)"
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915:Oxford Dictionary of National Biography
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668:Williams, Richard Tecwyn (May 1938).
594:Pryde J, Williams RT (2 April 1933).
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169:who founded the systematic study of
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357:Royal Postgraduate Medical School
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173:with the publication of his book
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21:Richard Williams (disambiguation)
434:Journal of Analytical Toxicology
891:"Library and Archive Catalogue"
281:He died on 29 December 1979 in
912:"Williams, (Richard) Tecwyn".
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820:National Institutes of Health
545:Pryde J, Williams RT (1936).
237:National Institutes of Health
224:, was into the metabolism of
1038:Alumni of Cardiff University
1023:Fellows of the Royal Society
932:UK public library membership
294:Honorary doctorate from the
16:Welsh biochemist (1909–1979)
1033:University of Ibadan alumni
324:Fellow of the Royal Society
257:Fellow of the Royal Society
199:University College, Cardiff
119:University College, Cardiff
78:University College, Cardiff
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648:Out of the Blue Artifacts
523:10.3109/00498257709036238
506:"Richard Tecwyn Williams"
483:10.3109/03602538308991399
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87:Josephine Teresa Sullivan
345:University of Wellington
210:University of Birmingham
123:University of Birmingham
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988:Article on R.T.Williams
969:Detoxication Mechanisms
847:The Biochemical Journal
471:Drug Metabolism Reviews
363:Queen Elizabeth College
283:Northwick Park Hospital
218:University of Liverpool
175:Detoxication mechanisms
157:Richard Tecwyn Williams
127:University of Liverpool
67:Northwick Park Hospital
32:Richard Tecwyn Williams
924:10.1093/ref:odnb/31837
414:10.1098/rsbm.1982.0026
303:University of Tübingen
504:Parke, D. V. (1977).
428:Jones, A. W. (2009).
331:Society of Toxicology
301:Honorary MD from the
193:Williams was born in
181:in the metabolism of
171:xenobiotic metabolism
110:Xenobiotic metabolism
447:10.1093/jat/33.9.623
351:University of Surrey
317:University of Ibadan
245:University of Ibadan
135:University of Ibadan
1018:British biochemists
772:Biochemical Journal
723:Biochemical Journal
674:Biochemical Journal
329:Merit award of the
310:University of Wales
296:University of Paris
930:(Subscription or
859:10.1042/bj0960390
784:10.1042/bj0380070
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61:(1979-12-29)
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1008:1979 deaths
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510:Xenobiotica
285:in London.
277:this memoir
195:Abertillery
48:Abertillery
997:Categories
934:required.)
897:1 November
600:Biochem. J
551:Biochem. J
516:(1–2): 1.
375:References
322:Elected a
167:biochemist
189:Biography
802:16747752
753:13607428
704:16746699
630:16745211
581:16746091
456:20040139
92:Children
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289:Awards
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164:Welsh
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41:Born
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