Knowledge (XXG)

Rigosertib

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295: 590: 24: 522:"Phase IIIB, Open-label, Multi-Center Study of the Efficacy and Safety of Rigosertib Administered as 72-hour Continuous Intravenous Infusions in Patients with Myelodysplastic Syndrome with Excess Blasts Progressing on or After Azacitidine or Decitabine" 107: 667: 657: 638: 334: 318:
InChI=1S/C21H25NO8S/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24/h5-11,22H,12-13H2,1-4H3,(H,23,24)/b8-7+
631: 662: 487: 624: 309: 444: 196: 412: 252: 273: 537:"Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent" 440: 436: 154: 147: 46: 36: 290: 604: 72: 451: 566: 608: 501: 174: 556: 548: 357: 82: 261: 601: 294: 127: 597: 561: 536: 406: 651: 241: 521: 552: 467: 589: 391: 186: 165: 570: 228: 23: 435:
as trade name) is a synthetic benzyl styryl sulfone in development by
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Except where otherwise noted, data are given for materials in their
342:: COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O 216: 118: 106: 95: 207: 278: 612: 458:)-ON 01910·Na has less cytotoxicity on cancer cells. 488:"physical and chemical data on chemispider website" 195: 240: 81: 668:Antineoplastic and immunomodulating drug stubs 632: 8: 639: 625: 293: 173: 15: 658:Antineoplastic and immunomodulating drugs 560: 260: 479: 339: 314: 289: 321:Key: OWBFCJROIKNMGD-BQYQJAHWSA-N 153: 146: 126: 7: 586: 584: 51:(2-Methoxy-5-{methyl}anilino)acetate 231: 215: 40:(2-Methoxy-5-{methyl}phenyl)glycine 611:. You can help Knowledge (XXG) by 14: 588: 375: 369: 22: 445:chronic myelomonocytic leukemia 409:(at 25 °C , 100 kPa). 384: 378: 363: 1: 553:10.1016/j.molcel.2017.09.012 684: 583: 663:Experimental cancer drugs 441:phase III clinical trials 403: 350: 330: 305: 65: 57: 45: 35: 30: 21: 502:"Onconova Therapeutics" 470:-destabilizing agent. 443:for the treatment of 437:Onconova Therapeutics 47:Systematic IUPAC name 439:. Rigosertib is in 399: g·mol 18: 452:geometrical isomer 431:sodium salt, with 413:Infobox references 16: 620: 619: 547:(1): 210–223.e6. 421:Chemical compound 419: 418: 274:CompTox Dashboard 108:Interactive image 675: 641: 634: 627: 602:immunomodulatory 592: 585: 575: 574: 564: 535:Jost, M (2017). 532: 526: 525: 518: 512: 511: 509: 508: 498: 492: 491: 484: 466:Rigosertib is a 398: 386: 380: 377: 371: 365: 358:Chemical formula 298: 297: 282: 280: 264: 244: 233: 219: 199: 177: 157: 150: 130: 110: 85: 26: 19: 683: 682: 678: 677: 676: 674: 673: 672: 648: 647: 646: 645: 581: 579: 578: 534: 533: 529: 524:. 29 June 2020. 520: 519: 515: 506: 504: 500: 499: 495: 486: 485: 481: 476: 464: 422: 415: 410: 396: 383: 374: 368: 360: 346: 343: 338: 337: 326: 323: 322: 319: 313: 312: 301: 283: 276: 267: 247: 234: 222: 202: 189: 180: 160: 133: 113: 99: 88: 75: 61: 53: 52: 41: 12: 11: 5: 681: 679: 671: 670: 665: 660: 650: 649: 644: 643: 636: 629: 621: 618: 617: 598:antineoplastic 593: 577: 576: 541:Molecular Cell 527: 513: 493: 478: 477: 475: 472: 463: 460: 420: 417: 416: 411: 407:standard state 404: 401: 400: 394: 388: 387: 381: 372: 366: 361: 356: 353: 352: 348: 347: 345: 344: 341: 333: 332: 331: 328: 327: 325: 324: 320: 317: 316: 308: 307: 306: 303: 302: 300: 299: 291:DTXSID30207984 286: 284: 272: 269: 268: 266: 265: 257: 255: 249: 248: 246: 245: 237: 235: 227: 224: 223: 221: 220: 212: 210: 204: 203: 201: 200: 192: 190: 185: 182: 181: 179: 178: 170: 168: 162: 161: 159: 158: 151: 143: 141: 135: 134: 132: 131: 123: 121: 115: 114: 112: 111: 102: 100: 93: 90: 89: 87: 86: 78: 76: 71: 68: 67: 63: 62: 59: 55: 54: 50: 49: 43: 42: 39: 33: 32: 28: 27: 13: 10: 9: 6: 4: 3: 2: 680: 669: 666: 664: 661: 659: 656: 655: 653: 642: 637: 635: 630: 628: 623: 622: 616: 614: 610: 607:article is a 606: 603: 599: 594: 591: 587: 582: 572: 568: 563: 558: 554: 550: 546: 542: 538: 531: 528: 523: 517: 514: 503: 497: 494: 489: 483: 480: 473: 471: 469: 461: 459: 457: 453: 448: 446: 442: 438: 434: 430: 426: 414: 408: 402: 395: 393: 390: 389: 362: 359: 355: 354: 349: 340: 336: 329: 315: 311: 304: 296: 292: 288: 287: 285: 275: 271: 270: 263: 259: 258: 256: 254: 251: 250: 243: 239: 238: 236: 230: 226: 225: 218: 214: 213: 211: 209: 206: 205: 198: 194: 193: 191: 188: 184: 183: 176: 172: 171: 169: 167: 164: 163: 156: 155:ChEMBL2013119 152: 149: 148:ChEMBL1241855 145: 144: 142: 140: 137: 136: 129: 125: 124: 122: 120: 117: 116: 109: 104: 103: 101: 97: 92: 91: 84: 80: 79: 77: 74: 70: 69: 64: 56: 48: 44: 38: 34: 29: 25: 20: 613:expanding it 595: 580: 544: 540: 530: 516: 505:. Retrieved 496: 482: 465: 455: 449: 432: 428: 424: 423: 128:CHEBI:145417 66:Identifiers 58:Other names 468:microtubule 351:Properties 83:592542-59-1 17:Rigosertib 652:Categories 507:2019-04-26 474:References 425:Rigosertib 392:Molar mass 262:67DOW7F9GL 187:IUPHAR/BPS 166:ChemSpider 94:3D model ( 73:CAS Number 37:IUPAC name 462:Mechanism 571:28985505 429:ON-01910 60:ON-01910 562:5640507 433:Estybon 242:6918736 229:PubChem 175:5293927 105:: 569:  559:  397:451.49 335:SMILES 217:D10154 139:ChEMBL 31:Names 596:This 310:InChI 119:ChEBI 96:JSmol 609:stub 605:drug 567:PMID 450:Its 253:UNII 208:KEGG 197:7833 600:or 557:PMC 549:doi 279:EPA 232:CID 654:: 565:. 555:. 545:68 543:. 539:. 447:. 373:25 367:21 640:e 633:t 626:v 615:. 573:. 551:: 510:. 490:. 456:Z 454:( 427:( 385:S 382:8 379:O 376:N 370:H 364:C 281:) 277:( 98:)

Index


IUPAC name
Systematic IUPAC name
CAS Number
592542-59-1
JSmol
Interactive image
ChEBI
CHEBI:145417
ChEMBL
ChEMBL1241855
ChEMBL2013119
ChemSpider
5293927
IUPHAR/BPS
7833
KEGG
D10154
PubChem
6918736
UNII
67DOW7F9GL
CompTox Dashboard
DTXSID30207984
Edit this at Wikidata
InChI
SMILES
Chemical formula
Molar mass
standard state

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