238:
InChI=1S/C98H113N7O43/c1-30-50(111)20-39-22-54(30)138-55-21-33(5-12-49(55)110)63(100)88(127)105-67-70(115)35-7-13-52-37(15-35)18-44-62-45-19-38-16-36(8-14-53(38)140-84(45)87(83(44)139-52)148-98-86(78(123)74(119)59(144-98)29-135-94-80(125)75(120)69(114)32(3)137-94)147-97-85(77(122)73(118)58(27-107)143-97)146-95-79(124)71(116)51(112)28-134-95)82(145-60-25-46(99)68(113)31(2)136-60)47-10-9-41(93(132)133-4)42-23-40(108)24-56(141-96-81(126)76(121)72(117)57(26-106)142-96)61(42)43-17-34(6-11-48(43)109)64(89(128)101-47)102-91(130)66(62)104-90(129)65(39)103-92(67)131/h5-8,11-17,20-24,31-32,41,46-47,51,57-60,63-82,85-86,94-98,106-126H,9-10,18-19,25-29,99-100H2,1-4H3,(H,101,128)(H,102,130)(H,103,131)(H,104,129)(H,105,127)/t31-,32+,41-,46+,47?,51-,57+,58-,59-,60+,63?,64?,65?,66?,67+,68-,69+,70+,71-,72+,73-,74-,75-,76-,77+,78+,79+,80-,81-,82+,85+,86-,94-,95+,96+,97-,98+/m0/s1
248:
InChI=1/C98H113N7O43/c1-30-50(111)20-39-22-54(30)138-55-21-33(5-12-49(55)110)63(100)88(127)105-67-70(115)35-7-13-52-37(15-35)18-44-62-45-19-38-16-36(8-14-53(38)140-84(45)87(83(44)139-52)148-98-86(78(123)74(119)59(144-98)29-135-94-80(125)75(120)69(114)32(3)137-94)147-97-85(77(122)73(118)58(27-107)143-97)146-95-79(124)71(116)51(112)28-134-95)82(145-60-25-46(99)68(113)31(2)136-60)47-10-9-41(93(132)133-4)42-23-40(108)24-56(141-96-81(126)76(121)72(117)57(26-106)142-96)61(42)43-17-34(6-11-48(43)109)64(89(128)101-47)102-91(130)66(62)104-90(129)65(39)103-92(67)131/h5-8,11-17,20-24,31-32,41,46-47,51,57-60,63-82,85-86,94-98,106-126H,9-10,18-19,25-29,99-100H2,1-4H3,(H,101,128)(H,102,130)(H,103,131)(H,104,129)(H,105,127)/t31-,32+,41-,46+,47?,51-,57+,58-,59-,60+,63?,64?,65?,66?,67+,68-,69+,70+,71-,72+,73-,74-,75-,76-,77+,78+,79+,80-,81-,82+,85+,86-,94-,95+,96+,97-,98+/m0/s1
77:
215:
140:
30:
335:
272:
CC1C(C(CC(O1)OC2C3C(=O)NC(C4=CC(=CC(=C4C5=C(C=CC(=C5)C(C(=O)N3)NC(=O)C6C7=CC(=C(C(=C7)OC8=CC=C2C=C8)OC9C(C(C(C(O9)COC1C(C(C(C(O1)C)O)O)O)O)O)OC1C(C(C(C(O1)CO)O)O)OC1C(C(C(CO1)O)O)O)OC1=CC=C(C=C1)C(C1C(=O)NC(C2=CC(=C(C(=C2)O)C)OC2=C(C=CC(=C2)C(C(=O)N1)N)O)C(=O)N6)O)O)OC1C(C(C(C(O1)CO)O)O)O)O)C(=O)O)N)O
431:
receptors). In the case of type 2B vWD, the gain-of-function mutation involves von
Willebrand's factor (VWF gene), and in platelet-type vWD, the receptor is the object of the mutation (GPIb). This increased binding causes vWD because the high-molecular weight multimers are removed from circulation
432:
in plasma since they remain attached to the patient's platelets. Thus, if the patient's platelet-poor plasma is used, the ristocetin cofactor assay will not agglutinate standardized platelets (i.e., pooled platelets from normal donors that are fixed in formalin), similar to the other types of vWD.
439:
prior to the assay to prevent von
Willebrand's factor stored in platelet granules from being released and participating in platelet aggregation. Thus, the ristocetin cofactor activity depends only upon high-molecular multimers of the factor present in circulating plasma.
415:
Through an unknown mechanism, the antibiotic ristocetin causes von
Willebrand factor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin is added to normal blood, it causes agglutination.
732:
665:
Borhany, Munira; Pahore, Zaen; ul Qadr, Zeeshan; Rehan, Muhammad; Naz, Arshi; Khan, Asif; Ansari, Saqib; Farzana, Tasneem; Nadeem, Muhammad; Raza, Syed Amir; Shamsi, Tahir (2010).
1746:
348:
725:
264:
718:
419:
In some types of vWD (types 2B and platelet-type), even very small amounts of ristocetin cause platelet aggregation when the patient's platelet-rich
17:
1971:
640:
2020:
229:
893:
833:
822:
1890:
427:
which cause the vWD high molecular-weight multimers to bind more tightly to their receptors on platelets (the alpha chains of
1776:
412:
multimers, so if ristocetin is added to blood lacking the factor (or its receptor—see below), the platelets will not clump.
586:
561:
405:
355:
942:
172:
2025:
1988:
1801:
1721:
848:
782:
193:
710:
1726:
853:
749:
470:
382:
1655:
1976:
1791:
1751:
858:
766:
393:
371:
135:
1815:
1766:
1756:
555:
428:
401:
97:
1796:
1781:
1761:
465:
409:
2015:
1880:
1786:
1731:
210:
1771:
1741:
1590:
1552:
509:
43:
1306:
1012:
787:
696:
688:
636:
531:
117:
1894:
1045:
843:
678:
386:
287:
181:
1682:
1126:
953:
448:
53:
214:
139:
1982:
912:
326:
2009:
1876:
1735:
1544:
1511:
1376:
1350:
1283:
1195:
1178:
1090:
1084:
1030:
1026:
996:
991:
986:
981:
971:
907:
878:
868:
376:
161:
128:
1645:
1562:
1405:
1263:
1248:
1054:
883:
757:
753:
487:
420:
408:. Platelet agglutination caused by ristocetin can occur only in the presence of
1957:
1935:
1904:
1898:
1824:
1704:
1694:
1580:
1572:
1557:
1471:
1441:
1436:
1431:
1426:
1421:
1400:
1389:
1361:
1355:
1311:
1273:
1253:
1238:
1186:
1064:
1021:
962:
928:
903:
873:
863:
741:
1945:
1940:
1908:
1884:
1855:
1833:
1699:
1672:
1622:
1603:
1534:
1524:
1486:
1476:
1466:
1451:
1446:
1394:
1365:
1331:
1321:
1301:
1258:
1228:
1223:
1213:
1182:
1108:
1080:
1059:
1035:
976:
967:
808:
314:
108:
692:
1952:
1838:
1689:
1667:
1640:
1635:
1630:
1608:
1598:
1529:
1500:
1491:
1461:
1416:
1340:
1335:
1326:
1316:
1296:
1268:
1243:
1233:
1218:
1208:
1203:
1163:
1158:
1151:
1140:
1130:
1121:
1002:
923:
918:
745:
700:
683:
666:
1928:
1519:
1495:
1481:
1456:
1411:
1384:
1345:
1291:
1146:
1135:
475:
455:
444:
436:
424:
390:
1832:
Insert into bacterial cell wall causing perforation and depolarization:
667:"Bleeding disorders in the tribe: result of consanguineous in breeding"
148:
29:
1678:
1174:
88:
325:
Except where otherwise noted, data are given for materials in their
1663:
1112:
812:
76:
66:
435:
In all forms of the ristocetin assay, the platelets are fixed in
714:
633:
Henry's
Clinical Diagnosis and Management by Laboratory Methods
198:
423:
is used. This paradox is explained by these types having
449:
442:
343:
1747:
Benzathine benzylpenicillin/procaine benzylpenicillin
385:. It is no longer used clinically because it caused
1918:
1868:
1847:
1823:
1814:
1714:
1654:
1621:
1589:
1571:
1543:
1510:
1375:
1282:
1194:
1173:
1107:
1073:
1044:
1011:
952:
941:
892:
832:
821:
807:
765:
660:
658:
656:
654:
652:
396:. It is now used solely to assay those functions
631:McPherson, Richard A.; Matthew R. Pincus (2006).
635:. Philadelphia: W. B. Saunders. pp. 760–2.
160:
52:
726:
8:
1820:
1191:
949:
829:
818:
804:
733:
719:
711:
213:
138:
116:
21:
1854:Inhibits PG elongation and crosslinking:
682:
180:
623:
400:in the diagnosis of conditions such as
269:
234:
209:
18:Ristocetin-induced platelet aggregation
447:by main disorders and agonists
129:
241:Key: SGAHMTIMAXYJKX-JWVHJGEPSA-N
96:
7:
251:Key: SGAHMTIMAXYJKX-JWVHJGEPBW
151:
14:
1879:subunit synthesis and transport:
671:Orphanet Journal of Rare Diseases
456:Platelet § Tests of function
333:
28:
329:(at 25 °C , 100 kPa).
1777:Imipenem/cilastatin/relebactam
1:
445:Platelet aggregation function
1802:Ticarcillin/clavulanic acid
1722:Amoxicillin/clavulanic acid
859:Phenoxymethylpenicillin (V)
849:Benzathine benzylpenicillin
381:, previously used to treat
2042:
587:Glanzmann's thrombasthenia
453:
425:gain-of-function mutations
15:
1966:
1727:Ampicillin/flucloxacillin
854:Procaine benzylpenicillin
383:staphylococcal infections
323:
280:
260:
225:
36:
27:
2021:Glycopeptide antibiotics
562:Bernard–Soulier syndrome
406:Bernard–Soulier syndrome
319:2053.89052
1792:Piperacillin/tazobactam
1752:Cefepime/enmetazobactam
372:glycopeptide antibiotic
1883:synthesis inhibition (
1767:Ceftolozane/tazobactam
1757:Cefoperazone/sulbactam
1656:β-lactamase inhibitors
684:10.1186/1750-1172-5-23
556:Von Willebrand disease
429:glycoprotein Ib (GPIb)
402:von Willebrand disease
1797:Sulbactam/durlobactam
1782:Meropenem/vaborbactam
1762:Ceftazidime/avibactam
894:β-lactamase resistant
834:β-lactamase sensitive
454:Further information:
410:von Willebrand factor
1787:Panipenem/betamipron
1732:Ampicillin/sulbactam
844:Benzylpenicillin (G)
778:cell wall by binding
490:inhibitor or defect
1772:Imipenem/cilastatin
1742:Aztreonam/avibactam
1553:Ceftaroline fosamil
578:Decreased or absent
544:Decreased or absent
510:Adrenergic receptor
459:
24:
2026:Chemical pathology
1993:Never to phase III
1925:Hydrolyze NAM-NAG
1013:Carboxypenicillins
776:layer of bacterial
772:(inhibit synthesis
443:
356:Infobox references
22:
2003:
2002:
1864:
1863:
1810:
1809:
1617:
1616:
1399:Antipseudomonal (
1307:Cefuroxime axetil
1103:
1102:
1099:
1098:
1046:Ureidopenicillins
937:
936:
801:
794:
790:
780:to and inhibiting
642:978-1-4160-0287-1
615:
614:
532:Collagen receptor
364:Chemical compound
362:
361:
194:CompTox Dashboard
78:Interactive image
2033:
1821:
1192:
1048:(4th generation)
1015:(4th generation)
956:(3rd generation)
954:Aminopenicillins
950:
897:(2nd generation)
837:(1st generation)
830:
819:
805:
800:
792:
788:
774:of peptidoglycan
770:
735:
728:
721:
712:
705:
704:
686:
662:
647:
646:
628:
558:(except Type 2B)
460:
452:
387:thrombocytopenia
374:, obtained from
346:
340:
337:
336:
288:Chemical formula
218:
217:
202:
200:
184:
164:
153:
142:
131:
120:
100:
80:
56:
32:
25:
2041:
2040:
2036:
2035:
2034:
2032:
2031:
2030:
2006:
2005:
2004:
1999:
1998:
1983:Clinical trials
1962:
1914:
1860:
1843:
1806:
1710:
1683:Clavulanic acid
1650:
1613:
1585:
1567:
1539:
1506:
1371:
1278:
1185:
1181:
1177:
1169:
1127:Antipseudomonal
1095:
1069:
1040:
1007:
944:
933:
896:
888:
836:
824:
797:transpeptidases
796:
786:
781:
779:
777:
775:
773:
771:
769:
761:
739:
709:
708:
664:
663:
650:
643:
630:
629:
625:
620:
458:
365:
358:
353:
352:
351: ?)
342:
338:
334:
330:
308:
304:
300:
296:
290:
276:
273:
268:
267:
256:
253:
252:
249:
243:
242:
239:
233:
232:
221:
203:
196:
187:
167:
154:
123:
103:
83:
70:
59:
46:
20:
12:
11:
5:
2039:
2037:
2029:
2028:
2023:
2018:
2008:
2007:
2001:
2000:
1997:
1996:
1995:
1994:
1991:
1980:
1974:
1968:
1967:
1964:
1963:
1961:
1960:
1955:
1950:
1949:
1948:
1943:
1933:
1932:
1931:
1922:
1920:
1916:
1915:
1913:
1912:
1902:
1888:
1872:
1870:
1866:
1865:
1862:
1861:
1859:
1858:
1851:
1849:
1845:
1844:
1842:
1841:
1836:
1829:
1827:
1818:
1812:
1811:
1808:
1807:
1805:
1804:
1799:
1794:
1789:
1784:
1779:
1774:
1769:
1764:
1759:
1754:
1749:
1744:
1739:
1729:
1724:
1718:
1716:
1712:
1711:
1709:
1708:
1702:
1697:
1692:
1688:non-β-lactam (
1686:
1676:
1670:
1660:
1658:
1652:
1651:
1649:
1648:
1643:
1638:
1633:
1627:
1625:
1619:
1618:
1615:
1614:
1612:
1611:
1606:
1601:
1595:
1593:
1587:
1586:
1584:
1583:
1577:
1575:
1569:
1568:
1566:
1565:
1560:
1555:
1549:
1547:
1545:5th generation
1541:
1540:
1538:
1537:
1532:
1527:
1522:
1516:
1514:
1512:4th generation
1508:
1507:
1505:
1504:
1498:
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1403:
1397:
1392:
1387:
1381:
1379:
1377:3rd generation
1373:
1372:
1370:
1369:
1359:
1353:
1348:
1343:
1338:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1288:
1286:
1284:2nd generation
1280:
1279:
1277:
1276:
1271:
1266:
1261:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
1211:
1206:
1200:
1198:
1196:1st generation
1189:
1179:Cephalosporins
1171:
1170:
1168:
1167:
1161:
1155:
1149:
1144:
1138:
1133:
1124:
1117:
1115:
1105:
1104:
1101:
1100:
1097:
1096:
1094:
1093:
1088:
1077:
1075:
1071:
1070:
1068:
1067:
1062:
1057:
1051:
1049:
1042:
1041:
1039:
1038:
1033:
1024:
1018:
1016:
1009:
1008:
1006:
1005:
1000:
994:
989:
984:
979:
974:
965:
959:
957:
947:
939:
938:
935:
934:
932:
931:
926:
921:
916:
913:Flucloxacillin
910:
900:
898:
890:
889:
887:
886:
881:
876:
871:
866:
861:
856:
851:
846:
840:
838:
827:
816:
802:
763:
762:
744:active on the
742:Antibacterials
740:
738:
737:
730:
723:
715:
707:
706:
648:
641:
622:
621:
619:
616:
613:
612:
606:
601:
596:
591:
590:
589:
581:
580:
575:
572:
569:
566:
565:
564:
559:
550:
549:
546:
541:
538:
535:
528:
527:
524:
521:
516:
513:
506:
505:
502:
499:
496:
491:
484:
483:
478:
473:
468:
463:
363:
360:
359:
354:
332:
331:
327:standard state
324:
321:
320:
317:
311:
310:
306:
302:
298:
294:
291:
286:
283:
282:
278:
277:
275:
274:
271:
263:
262:
261:
258:
257:
255:
254:
250:
247:
246:
244:
240:
237:
236:
228:
227:
226:
223:
222:
220:
219:
211:DTXSID30894853
206:
204:
192:
189:
188:
186:
185:
177:
175:
169:
168:
166:
165:
157:
155:
147:
144:
143:
133:
125:
124:
122:
121:
113:
111:
105:
104:
102:
101:
93:
91:
85:
84:
82:
81:
73:
71:
64:
61:
60:
58:
57:
49:
47:
42:
39:
38:
34:
33:
13:
10:
9:
6:
4:
3:
2:
2038:
2027:
2024:
2022:
2019:
2017:
2014:
2013:
2011:
1992:
1990:
1987:
1986:
1984:
1981:
1978:
1975:
1973:
1970:
1969:
1965:
1959:
1956:
1954:
1951:
1947:
1944:
1942:
1939:
1938:
1937:
1934:
1930:
1927:
1926:
1924:
1923:
1921:
1917:
1910:
1906:
1903:
1900:
1896:
1892:
1889:
1886:
1882:
1878:
1874:
1873:
1871:
1869:Intracellular
1867:
1857:
1853:
1852:
1850:
1846:
1840:
1837:
1835:
1831:
1830:
1828:
1826:
1822:
1819:
1817:
1813:
1803:
1800:
1798:
1795:
1793:
1790:
1788:
1785:
1783:
1780:
1778:
1775:
1773:
1770:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1737:
1736:Sultamicillin
1733:
1730:
1728:
1725:
1723:
1720:
1719:
1717:
1713:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1687:
1684:
1680:
1677:
1674:
1671:
1669:
1665:
1662:
1661:
1659:
1657:
1653:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1628:
1626:
1624:
1620:
1610:
1607:
1605:
1602:
1600:
1597:
1596:
1594:
1592:
1588:
1582:
1579:
1578:
1576:
1574:
1570:
1564:
1561:
1559:
1556:
1554:
1551:
1550:
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1546:
1542:
1536:
1533:
1531:
1528:
1526:
1523:
1521:
1518:
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1515:
1513:
1509:
1502:
1499:
1497:
1493:
1490:
1488:
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1483:
1480:
1478:
1475:
1473:
1470:
1468:
1465:
1463:
1460:
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1407:
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1402:
1398:
1396:
1393:
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1388:
1386:
1383:
1382:
1380:
1378:
1374:
1367:
1363:
1360:
1357:
1354:
1352:
1351:Cefbuperazone
1349:
1347:
1344:
1342:
1339:
1337:
1333:
1330:
1328:
1325:
1323:
1320:
1318:
1315:
1313:
1310:
1308:
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1289:
1287:
1285:
1281:
1275:
1272:
1270:
1267:
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1262:
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1230:
1227:
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1212:
1210:
1207:
1205:
1202:
1201:
1199:
1197:
1193:
1190:
1188:
1184:
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1165:
1162:
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1156:
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1150:
1148:
1145:
1142:
1139:
1137:
1134:
1132:
1128:
1125:
1123:
1120:Carbapenems (
1119:
1118:
1116:
1114:
1110:
1106:
1092:
1091:Sulbenicillin
1089:
1086:
1085:Pivmecillinam
1082:
1079:
1078:
1076:
1072:
1066:
1063:
1061:
1058:
1056:
1053:
1052:
1050:
1047:
1043:
1037:
1034:
1032:
1031:Carindacillin
1028:
1027:Carbenicillin
1025:
1023:
1020:
1019:
1017:
1014:
1010:
1004:
1001:
998:
997:Talampicillin
995:
993:
992:Metampicillin
990:
988:
987:Lenampicillin
985:
983:
982:Bacampicillin
980:
978:
975:
973:
972:Pivampicillin
969:
966:
964:
961:
960:
958:
955:
951:
948:
946:
940:
930:
927:
925:
922:
920:
917:
914:
911:
909:
908:Dicloxacillin
905:
902:
901:
899:
895:
891:
885:
882:
880:
879:Clometocillin
877:
875:
872:
870:
869:Pheneticillin
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
841:
839:
835:
831:
828:
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820:
817:
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784:
768:
764:
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547:
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451:
446:
441:
438:
433:
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422:
417:
413:
411:
407:
403:
399:
395:
394:agglutination
392:
388:
384:
380:
378:
377:Amycolatopsis
373:
369:
357:
350:
345:
328:
322:
318:
316:
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137:
134:
132:
130:ECHA InfoCard
127:
126:
119:
115:
114:
112:
110:
107:
106:
99:
98:ChEMBL1095986
95:
94:
92:
90:
87:
86:
79:
75:
74:
72:
68:
63:
62:
55:
51:
50:
48:
45:
41:
40:
35:
31:
26:
19:
1907:inhibitors (
1897:inhibitors (
1825:Lipopeptides
1816:Polypeptides
1715:Combinations
1646:Nocardicin A
1563:Ceftobiprole
1406:Cefoperazone
1264:Cefaloridine
1249:Cefaloglycin
1187:Carbacephems
1055:Piperacillin
884:Penamecillin
785:, a group of
674:
670:
632:
626:
609:
603:
598:
593:
577:
543:
518:
493:
488:P2Y receptor
480:
434:
418:
414:
397:
375:
367:
366:
37:Identifiers
2016:Antibiotics
1979:from market
1958:Teixobactin
1936:Tyrothricin
1905:bactoprenol
1899:Cycloserine
1705:Vaborbactam
1695:Durlobactam
1623:Monobactams
1581:Cefiderocol
1573:Siderophore
1558:Ceftolozane
1472:Cefpimizole
1442:Cefpodoxime
1437:Cefpiramide
1432:Cefmenoxime
1427:Ceftizoxime
1422:Cefdaloxime
1401:Ceftazidime
1390:Ceftriaxone
1362:Carbacephem
1356:Cefmetazole
1312:Cefamandole
1274:Cefatrizine
1254:Cefacetrile
1239:Cefroxadine
1183:Cephamycins
1109:Carbapenems
1065:Mezlocillin
1022:Ticarcillin
963:Amoxicillin
929:Methicillin
904:Cloxacillin
874:Azidocillin
864:Propicillin
809:Penicillins
471:Epinephrine
281:Properties
136:100.014.336
23:Ristocetin
2010:Categories
1946:Tyrocidine
1941:Gramicidin
1909:Bacitracin
1885:Fosfomycin
1856:Ramoplanin
1834:Daptomycin
1700:Relebactam
1673:Tazobactam
1604:Cefquinome
1591:Veterinary
1535:Cefquinome
1525:Cefozopran
1487:Ceftiolene
1477:Cefsulodin
1467:Cefodizime
1452:Cefditoren
1447:Ceftibuten
1395:Cefotaxime
1366:Loracarbef
1332:Cephamycin
1322:Ceforanide
1302:Cefuroxime
1259:Cefalonium
1229:Cefazaflur
1224:Cefazedone
1214:Cefadroxil
1081:Mecillinam
1060:Azlocillin
1036:Temocillin
977:Hetacillin
968:Ampicillin
618:References
608:Normal or
481:Ristocetin
404:(vWD) and
368:Ristocetin
315:Molar mass
182:ZP3E6S00IL
109:ChemSpider
65:3D model (
44:CAS Number
16:See also:
1989:Phase III
1977:Withdrawn
1953:Isoniazid
1839:Surfactin
1690:Avibactam
1668:Sulbactam
1641:Carumonam
1636:Tigemonam
1631:Aztreonam
1609:Cefovecin
1599:Ceftiofur
1530:Cefpirome
1501:Latamoxef
1492:Oxacephem
1462:Cefetamet
1417:Cefcapene
1341:Cefotetan
1336:Cefoxitin
1327:Cefuzonam
1317:Cefonicid
1297:Cefprozil
1269:Cefalotin
1244:Ceftezole
1234:Cefradine
1219:Cefapirin
1209:Cefalexin
1204:Cefazolin
1164:Ritipenem
1159:Faropenem
1152:Panipenem
1141:Meropenem
1131:Doripenem
1122:Ertapenem
1003:Epicillin
924:Nafcillin
919:Oxacillin
767:β-lactams
746:cell wall
693:1750-1172
610:decreased
604:Decreased
599:Decreased
594:Decreased
519:Decreased
494:Decreased
54:1404-55-3
1929:lysozyme
1875:Inhibit
1520:Cefepime
1496:Flomoxef
1482:Cefteram
1457:Cefotiam
1412:Cefdinir
1385:Cefixime
1346:Cefminox
1292:Cefaclor
1157:Penems (
1147:Biapenem
1136:Imipenem
945:spectrum
943:Extended
825:spectrum
795:-alanine
791:-alanyl-
750:envelope
701:20822539
476:Collagen
437:formalin
398:in vitro
391:platelet
162:24846002
118:21106475
1175:Cephems
548:Normal
534:defect
526:Normal
512:defect
504:Normal
349:what is
347: (
309:
149:PubChem
1972:WHO-EM
1679:Clavam
1113:Penems
823:Narrow
813:Penams
699:
691:
639:
574:Normal
571:Normal
568:Normal
540:Normal
537:Normal
523:Normal
515:Normal
501:Normal
498:Normal
421:plasma
379:lurida
344:verify
341:
265:SMILES
89:ChEMBL
1919:Other
1891:DADAL
1848:Other
1664:Penam
1074:Other
677:(1).
370:is a
230:InChI
67:JSmol
783:PBPs
758:J01D
754:J01C
748:and
697:PMID
689:ISSN
637:ISBN
450:edit
389:and
173:UNII
1881:NAM
679:doi
466:ADP
299:108
199:EPA
152:CID
2012::
1985::
1895:AR
1877:PG
1111:/
1029:/
695:.
687:.
673:.
669:.
651:^
307:44
295:94
1911:)
1901:)
1893:/
1887:)
1738:)
1734:(
1707:)
1685:)
1681:(
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1666:(
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1364:(
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1143:)
1129:(
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1083:(
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970:(
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906:(
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811:(
799:)
793:D
789:D
760:)
756:-
752:(
734:e
727:t
720:v
703:.
681::
675:5
645:.
339:N
305:O
303:8
301:N
297:H
293:C
201:)
197:(
69:)
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