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models to the study of taste transduction and chemosensation. He has made numerous seminal discoveries in the taste field, including the identification and molecular cloning of taste specific receptors, G proteins, channels and other taste signal transduction elements.
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Max, M.; Shanker, Y.G.; Huang, L.; Rong, M.; Liu, Z.; Campagne, F.; Weinstein, H.; Damak, S.; Margolskee, R.F. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac".
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Jang, H.J.; Kokrashvili, Z.; Theodorakis, M.J.; Carlson, O.D.; Kim, B.J.; Zhou, J.; Kim, H.H.; Xu, X.; Chan, S.L.; Juhaszova, M.; Bernier, M.; Mosinger, B.; Margolskee, R.F.; Egan, J.M. (Sep 2007).
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Perez, C.; Huang, L.; Rong, M.; Kozak, J.A.; Preuss, A.K.; Zhang, H.; Max, M.; Margolskee, R.F. (Nov 2002). "A transient receptor potential channel expressed in taste receptor cells".
245:, a taste cell expressed G protein. Subsequently, Margolskee has demonstrated that gustducin is critical to the transduction of compounds that humans consider bitter, sweet or
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cation channel in 2002. Much of his current work is focused on 'taste cells of the gut' and 'endocrine cells of the tongue'. In 2007, he published back-to-back papers in the
193:. In 1996, Margolskee joined the faculty of the Mount Sinai School of Medicine. In 2009, he joined the faculty at the Monell Center. His work has been published in
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Margolskee, R.F.; Dyer, J.; Kokrashvili, Z.; Salmon, K.S.; Ilegems, E.; Daly, K.; Maillet, E.L.; Ninomiya, Y.; Mosinger, B.; Shirazi-Beechey, S.P. (Sep 2007).
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McLaughlin, S.K.; McKinnon, P.J.; Margolskee, R.F. (June 1992). "Gustducin is a taste-cell-specific G protein closely related to the transducins".
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Margolskee’s basic science research focus has been on the molecular mechanisms of taste transduction, utilizing molecular biology,
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shedding light on how the gut "tastes" nutrients. This new area of research has important implications for diabetes and obesity.
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Among his honors and awards are the Monell
Mastertaste-Manheimer Award (now the Manheimer-Kerry award) and the IFF Award.
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to study the mechanisms of signal transduction in mammalian taste cells. In 1992, his laboratory discovered
128:. Margolskee is also the a co-founder of Redpoint Bio. Margolskee has been a pioneer in the application of
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Wong, G.T.; Gannon, K.S.; Margolskee, R.F. (1996). "Transduction of bitter and sweet taste by gustducin".
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Margolskee’s first faculty appointment was in
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Proceedings of the
National Academy of Sciences USA
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Proceedings of the
National Academy of Sciences USA
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157:. He received his an M.D. and a Ph.D in
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283:"Robert F. Margolskee Profile"
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