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Roger D. Kornberg

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435: 47: 1768: 485:" when it is bound to proteins in this manner). Within the nucleosome, Kornberg found that roughly 200 bp of DNA are wrapped around an octamer of histone proteins. With Yahli Lorch, Kornberg showed that a nucleosome on a promoter prevents the initiation of transcription, leading to the recognition of a functional role for the nucleosome, which serves as a general gene repressor. 1736: 427: 294: 2028: 496:, a simple unicellular eukaryote, which they then used to isolate in a purified form all of the several dozen proteins required for the transcription process. Through the work of Kornberg and others, it has become clear that these protein components are remarkably conserved across the full spectrum of eukaryotes, from yeast to human cells. 505:. As noted by the Nobel Prize committee, "the great complexity of eukaryotic organisms is actually enabled by the fine interplay between tissue-specific substances, enhancers in the DNA and Mediator. The discovery of Mediator is therefore a true milestone in the understanding of the transcription process." 526:
As a graduate student at Stanford University, Kornberg's studied the rotation of phospholipids and defined for the first time the dynamics of lipids in the membrane. Kornberg called the movement of lipid from one leaflet to the other flip-flop because he had studied only a few years before electronic
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of RNA polymerase at atomic resolution. He has recently extended these studies to obtain structural images of RNA polymerase associated with accessory proteins. Through these studies, Kornberg has created an actual picture of how transcription works at a molecular level. According to the Nobel Prize
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membranes gained from his graduate studies to devise a technique for the formation of two-dimensional protein crystals on lipid bilayers. These 2D crystals could then be analyzed using electron microscopy to derive low-resolution images of the protein's structure. Eventually, Kornberg was able to use
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Kornberg and his research group have made several fundamental discoveries concerning the mechanisms and regulation of eukaryotic transcription. While a graduate student working with Harden McConnell at Stanford in the late 1960s, he discovered the "flip-flop" and lateral diffusion of phospholipids in
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At the same time as Kornberg was pursuing these biochemical studies of the transcription process, he devoted two decades to the development of methods to visualize the atomic structure of RNA polymerase and its associated protein components. Initially, Kornberg took advantage of expertise with lipid
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committee, "the truly revolutionary aspect of the picture Kornberg has created is that it captures the process of transcription in full flow. What we see is an RNA-strand being constructed, and hence the exact positions of the DNA, polymerase and RNA during this process."
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Using this system, Kornberg made the major discovery that transmission of gene regulatory signals to the RNA polymerase machinery is accomplished by an additional protein complex that they dubbed
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in Cambridge, England and then an Assistant Professor of Biological Chemistry at Harvard Medical School in 1976, before moving to his present position as Professor of Structural Biology at
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Lorch, Yahli; LaPointe, Janice W.; Kornberg, Roger D. (1987). "Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones".
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Kornberg identified the role of RNA polymerase II and other proteins in DNA transcription, creating three-dimensional images of the protein cluster using
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as the basic protein complex packaging chromosomal DNA in the nucleus of eukaryotic cells (chromosomal DNA is often termed "
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Gnatt, A. L. (2001). "Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 A Resolution".
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Kornberg has served on the Scientific Advisory Boards of the following companies: Cocrystal Discovery, Inc (Chairman),
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Bushnell, D. A. (2004). "Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms".
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Miracles in Biochemistry: The contribution of the Nobel laureates to the field of Biochemistry
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Kornberg, R. D. (1974). "Chromatin Structure: A Repeating Unit of Histones and DNA".
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Hartl, Franz-Ulrich (2001). "Roger D. Kornberg Felix Hoppe-Seyler Lecturer 2001".
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2001: Hoppe-Seyler Award, Society for Biochemistry and Molecular Biology, Germany
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Proceedings of the National Academy of Sciences of the United States of America
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later succeeded in the development of a faithful transcription system from
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in 2006 for his studies of the process by which genetic information from
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Kelleher, Raymond J.; Flanagan, Peter M.; Kornberg, Roger D. (1990).
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bilayer membranes. Meanwhile, as a postdoctoral fellow working with
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Epand, Richard M.; Ruysschaert, Jean-Marie (September 25, 2017).
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The biophysics of cell membranes : biological consequences
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2009: Elected a Foreign Member of the Royal Society (ForMemRS)
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Members of the United States National Academy of Sciences
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in 1978. Since 2004, Kornberg has been the editor of the
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American biochemist and professor of structural biology
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Members of the European Molecular Biology Organization
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Jornal Brasileiro de Patologia e Medicina Laboratorial
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Fellows of the American Academy of Arts and Sciences
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Kornberg was awarded the 8: 1551:Kornberg, RD; McConnell, HM (October 1971). 988:Vasmatkar, Pashupat; Kamaljit, Kaur (2019). 570:Kornberg has received the following awards: 1079: 1077: 765:The Diffusion of Phospholipids in Membranes 244:The Diffusion of Phospholipids in Membranes 4009: 3995: 3987: 3445: 3431: 3423: 3196: 3182: 3174: 1796: 1782: 1774: 1766: 792: 790: 364:who was also a biochemist. He earned his 45: 29: 1586: 1576: 1440: 1371: 1271: 1231: 1097: 1039: 965:"Jewish Nobel Prize Winners in Chemistry" 907: 897: 599:Technion – Israel Institute of Technology 438:Roger D. Kornberg (third from left) with 414:. He serves on the Board of Directors of 108:Transmission of genetic information from 1696:"The 2005 Alfred P. Sloan, Jr. Laureate" 559:, Can-Fite BioPharma, Ltd, Simploud and 3454:Eli Lilly Award in Biological Chemistry 1616:. Singapore: Springer. pp. 33–34. 737: 735: 731: 605:Gairdner Foundation International Award 577:Eli Lilly Award in Biological Chemistry 1022:Richardson, Charles C. (2 June 2015). 849:Stanford University School of Medicine 1041:10.1146/annurev-biochem-060614-033850 758: 756: 356:family, the eldest son of biochemist 305:(born April 24, 1947) is an American 7: 4391:Foreign members of the Royal Society 1084:Stoddart, Charlotte (1 March 2022). 561:Teva Pharmaceutical Industries, Ltd. 384:from Stanford in 1972 supervised by 1312:"The Nobel Prize in Chemistry 2006" 1064:"Annual Reviews Board of Directors" 821:"The Nobel Prize in Chemistry 2006" 767:(PhD thesis). Stanford University. 4456:Annual Reviews (publisher) editors 25: 867:Royal Swedish Academy of Sciences 651:University of Southern California 551:, Ltd, Oplon Ltd (Chairman), and 2026: 1734: 631:Grand Prix Charles-Leopold Mayer 292: 1233:10.1590/S1676-24442001000400001 402:Laboratory of Molecular Biology 360:, who won the Nobel Prize, and 228:Laboratory of Molecular Biology 1442:11858/00-001M-0000-0015-8723-C 1373:11858/00-001M-0000-0015-8729-F 1024:"It Seems Like Only Yesterday" 763:Kornberg, Roger David (1972). 721:List of Jewish Nobel laureates 693:American Philosophical Society 223:Hebrew University of Jerusalem 1: 1028:Annual Review of Biochemistry 899:10.1016/S0021-9258(20)38209-0 659:Cancer Research Foundation’s 581:1982: Passano Award from the 488:Kornberg's research group at 411:Annual Review of Biochemistry 4371:Nobel laureates in Chemistry 1273:10.1016/0092-8674(90)90685-8 1185:10.1016/0092-8674(87)90561-7 1142:10.1126/science.184.4139.868 942:Kornberg Nobel Prize lecture 880:N, Kresge; Al., Et (2009). 4472: 4431:Stanford University alumni 4406:Jewish American scientists 683:Louisa Gross Horwitz Prize 661:Alfred P. Sloan, Jr. Prize 333:, "the molecular basis of 161:Alfred P. Sloan, Jr. Prize 155:Louisa Gross Horwitz Prize 4441:Scientists from St. Louis 4401:Harvard University alumni 3460: 3350: 2024: 1539:A family story about life 1099:10.1146/knowable-022822-1 539:Industrial collaborations 291: 266: 188: 44: 4376:American Nobel laureates 4340:William, Prince of Wales 2950:Venkatraman Ramakrishnan 2229:Wendell Meredith Stanley 1809:Nobel Prize in Chemistry 677:Nobel Prize in Chemistry 671:University of Pittsburgh 557:Protalix BioTherapeutics 547:Corporation (Chairman), 527:circuit elements called 344:Early life and education 323:Nobel Prize in Chemistry 149:Nobel Prize in Chemistry 4446:Massry Prize recipients 1578:10.1073/pnas.68.10.2564 1502:10.1126/science.1090838 1433:10.1126/science.1059495 1364:10.1126/science.1059493 703:2012: Honorary Fellow, 647:Keck School of Medicine 619:2002: ASBMB-Merck Award 515:3-dimensional structure 406:Stanford Medical School 4451:Chemists from Missouri 4416:Jewish Nobel laureates 3356:Nobel Prize recipients 3308:Physiology or Medicine 3114:Emmanuelle Charpentier 3102:M. Stanley Whittingham 2073:Hans von Euler-Chelpin 705:Ruppin Academic Center 458: 431: 218:Harvard Medical School 3657:Charles C. Richardson 2484:Christian B. Anfinsen 2124:FrĂ©dĂ©ric Joliot-Curie 511:X-ray crystallography 463:X-ray crystallography 437: 429: 398:postdoctoral research 348:Kornberg was born in 4381:American biochemists 3921:Christopher J. Chang 3897:Paul J. Hergenrother 3873:Benjamin Cravatt III 3771:Jacqueline K. Barton 3723:Christopher T. Walsh 3146:Karl Barry Sharpless 2643:Dudley R. Herschbach 2468:Luis Federico Leloir 1646:Biological Chemistry 1214:Capa, Nossa (2001). 303:Roger David Kornberg 4222:Henning Sirringhaus 3879:Dewey G. McCafferty 3807:Stuart L. Schreiber 3741:Harold M. Weintraub 3645:Phillips W. Robbins 3138:Carolyn R. Bertozzi 3050:Jean-Pierre Sauvage 2787:Jens Christian Skou 2755:F. Sherwood Rowland 2667:Charles J. Pedersen 2631:Herbert A. Hauptman 2324:Vincent du Vigneaud 1941:Richard Willstätter 1825:Jacobus van 't Hoff 1658:10.1515/BC.2001.139 1569:1971PNAS...68.2564K 1494:2004Sci...303..983B 1425:2001Sci...292.1876G 1419:(5523): 1876–1882. 1356:2001Sci...292.1863C 1350:(5523): 1863–1876. 1335:Cramer, P. (2001). 1216:"Our Journal Cover" 1134:1974Sci...184..868K 743:"Roger D. Kornberg" 687:Columbia University 553:Pacific Biosciences 386:Harden M. McConnell 350:St. Louis, Missouri 319:Stanford University 261:Harden M. McConnell 213:Stanford University 95:Stanford University 74:St. Louis, Missouri 4324:Steven D. Tanksley 4200:Richard Passingham 4183:Arthur B. McDonald 4136:Christopher Hunter 3903:Scott K. Silverman 3885:Linda Hsieh-Wilson 3867:Andreas Matouschek 3825:Gregory L. Verdine 3789:George L. McLendon 3591:Harold A. Scheraga 3501:Earl A. Evans, Jr. 3098:John B. Goodenough 3026:William E. Moerner 2906:Richard R. Schrock 2878:Roderick MacKinnon 2850:K. Barry Sharpless 2675:Johann Deisenhofer 2504:Geoffrey Wilkinson 2500:Ernst Otto Fischer 2424:Robert S. Mulliken 2360:Jaroslav HeyrovskĂ˝ 2308:Hermann Staudinger 2128:Irène Joliot-Curie 1765:on Nobelprize.org 626:in Cancer Research 583:Passano Foundation 459: 432: 396:Kornberg became a 374:Harvard University 315:structural biology 200:Structural biology 89:Harvard University 4348: 4347: 4304:Roger D. Kornberg 4294:H. Robert Horvitz 4251:Jonathan Tennyson 4160:Dimitris Kioussis 3984: 3983: 3957:Bradley Pentelute 3927:Matthew D. Disney 3735:Roger D. Kornberg 3717:Charles R. Cantor 3693:James E. Dahlberg 3663:Mario R. Capecchi 3639:Gerald M. Edelman 3627:William P. Jencks 3585:Robert A. Alberty 3579:William F. Neuman 3507:Herbert E. Carter 3420: 3419: 3333:Economic Sciences 3223:Roger D. Kornberg 3171: 3170: 3154:Moungi G. Bawendi 3074:Richard Henderson 2918:Roger D. Kornberg 2886:Aaron Ciechanover 2719:Rudolph A. Marcus 2623:Robert Merrifield 2559:Peter D. Mitchell 2332:Cyril Hinshelwood 2093:Friedrich Bergius 2017:Richard Zsigmondy 1933:Theodore Richards 1881:Ernest Rutherford 1763:Roger D. Kornberg 1752:Roger D. Kornberg 1488:(5660): 983–988. 1128:(4139): 868–871. 1090:Knowable Magazine 635:2003: Elected to 566:Awards and honors 366:bachelor's degree 300: 299: 190:Scientific career 16:(Redirected from 4463: 4245:Jesper Svejstrup 4228:Maurice Skolnick 4154:Jonathan Keating 4142:Graham Hutchings 4115:Nicholas Harberd 4045:Ross J. Anderson 4040:Robert Ainsworth 4011: 4004: 3997: 3988: 3831:Alanna Schepartz 3795:Peter G. Schultz 3765:James E. Rothman 3753:David V. Goeddel 3729:Phillip A. Sharp 3711:Robert G. Roeder 3681:Bruce M. Alberts 3651:Gordon G. Hammes 3567:Nathan O. Kaplan 3555:John M. Buchanan 3537:Dilworth Woodley 3513:Joseph S. Fruton 3495:David Rittenberg 3471:Harold S. Alcott 3465:William M. Allen 3447: 3440: 3433: 3424: 3358: 3198: 3191: 3184: 3175: 3164: 3162:Alexei I. Ekimov 3148: 3142:Morten P. 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Sumner 2218: 2210: 2202: 2194: 2188: 2187: 2181: 2180: 2174: 2173: 2168:Leopold RuĹľiÄŤka 2164:Adolf Butenandt 2161: 2153: 2141: 2133: 2121: 2113: 2107: 2106: 2101:Irving Langmuir 2098: 2086: 2078: 2066: 2058: 2050: 2042: 2031: 2027: 2022: 2014: 2008: 2007: 1999: 1991: 1986:Frederick Soddy 1983: 1975: 1969: 1968: 1960: 1954: 1953: 1947: 1946: 1938: 1930: 1922: 1913:Victor Grignard 1910: 1902: 1894: 1889:Wilhelm Ostwald 1886: 1878: 1870: 1862: 1854: 1846: 1838: 1830: 1822: 1811: 1802: 1759: 1758: 1757: 1739: 1735: 1730: 1725: 1718: 1714: 1705: 1703: 1694: 1693: 1689: 1643: 1642: 1638: 1628: 1626: 1624: 1609: 1608: 1604: 1550: 1549: 1545: 1537: 1533: 1479: 1478: 1474: 1410: 1409: 1405: 1339: 1334: 1333: 1329: 1320: 1318: 1310: 1309: 1305: 1253: 1252: 1248: 1238: 1236: 1213: 1212: 1208: 1170: 1169: 1165: 1119: 1118: 1114: 1104: 1102: 1083: 1082: 1075: 1062: 1061: 1057: 1021: 1020: 1016: 1006: 1004: 1002: 987: 986: 982: 973: 971: 963: 962: 958: 951: 947: 940: 936: 929: 925: 879: 878: 874: 861: 860: 856: 843: 842: 838: 829: 827: 819: 818: 814: 796: 795: 788: 762: 761: 754: 747:people.embo.org 741: 740: 733: 729: 717: 712: 710: 637:EMBO Membership 589:Ciba-Drew Award 568: 541: 535:and floppases. 524: 522:Lipids membrane 424: 394: 358:Arthur Kornberg 346: 274: 248: 232: 184: 179:Ciba-Drew Award 100: 82:Alma mater 77: 71: 68: 62: 60: 52: 40: 35: 28: 23: 22: 15: 12: 11: 5: 4469: 4467: 4459: 4458: 4453: 4448: 4443: 4438: 4433: 4428: 4423: 4418: 4413: 4408: 4403: 4398: 4393: 4388: 4383: 4378: 4373: 4368: 4363: 4353: 4352: 4346: 4345: 4343: 4342: 4336: 4334: 4330: 4329: 4327: 4326: 4321: 4319:Rashid Sunyaev 4316: 4311: 4306: 4301: 4299:Thomas Kailath 4296: 4291: 4285: 4283: 4279: 4278: 4276: 4275: 4270: 4263: 4258: 4253: 4248: 4241: 4236: 4231: 4224: 4219: 4214: 4209: 4206:Guy Richardson 4202: 4197: 4190: 4185: 4180: 4175: 4170: 4167:Stephen Larter 4163: 4156: 4151: 4148:Peter Isaacson 4144: 4139: 4132: 4130:Christine Holt 4127: 4125:Brian Hemmings 4122: 4117: 4112: 4107: 4102: 4097: 4092: 4087: 4082: 4077: 4072: 4067: 4062: 4057: 4052: 4047: 4042: 4036: 4034: 4030: 4029: 4016: 4014: 4013: 4006: 3999: 3991: 3982: 3981: 3979: 3978: 3972: 3966: 3960: 3954: 3948: 3942: 3936: 3930: 3924: 3918: 3915:Nathanael Gray 3912: 3906: 3900: 3894: 3888: 3882: 3876: 3870: 3864: 3858: 3852: 3846: 3843:Chaitan Khosla 3840: 3834: 3828: 3822: 3819:Jeremy M. 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Index

Roger Kornberg
ForMemRS

St. Louis, Missouri
Harvard University
Stanford University
DNA
RNA
EMBO Member
Nobel Prize in Chemistry
Louisa Gross Horwitz Prize
Alfred P. Sloan, Jr. Prize
Gairdner Award
Harvey Prize
Ciba-Drew Award
Structural biology
Stanford University
Harvard Medical School
Hebrew University of Jerusalem
Laboratory of Molecular Biology
Thesis
The Diffusion of Phospholipids in Membranes
Doctoral advisor
Harden M. McConnell
kornberg.stanford.edu

biochemist
professor
structural biology
Stanford University

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