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Viale, Andrea; Pettazzoni, Piergiorgio; Lyssiotis, Costas A.; Ying, Haoqiang; Sánchez, Nora; Marchesini, Matteo; Carugo, Alessandro; Green, Tessa; Seth, Sahil; Giuliani, Virginia; Kost-Alimova, Maria; Muller, Florian; Colla, Simona; Nezi, Luigi; Genovese, Giannicola; Deem, Angela K.; Kapoor, Avnish;
413:
Son, Jaekyoung; Lyssiotis, Costas A.; Ying, Haoqiang; Wang, Xiaoxu; Hua, Sujun; Ligorio, Matteo; Perera, Rushika M.; Ferrone, Cristina R.; Mullarky, Edouard; Shyh-Chang, Ng; Kang, Ya'an; Fleming, Jason B.; Bardeesy, Nabeel; Asara, John M.; Haigis, Marcia C.; DePinho, Ronald A.; Cantley, Lewis C.;
234:
DePinho publicly announced his resignation as MD Anderson president on March 8, 2017, after scrutiny over the administration of the organization had put him in the spotlight. "DePinho's five-and-a-half years at the helm of the world's largest cancer center were marked by unprecedented turbulence,
218:
DePinho is
Professor and former president in the Department of Cancer Biology at The University of Texas MD Anderson Cancer Center in Houston, Texas, and holds the Harry Graves Burkhart III Distinguished University Chair in Cancer Biology. He assumed the presidency at MD Anderson on September 1,
257:
DePinho's scientific program has made basic discoveries underlying cancer in the aged and factors governing acquired and inherited degenerative disorders. His laboratory established the concept of tumor maintenance, discovered a core pathway of aging and demonstrated that aging is a reversible
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2011. There, he founded the
Institute for Applied Cancer Science to accelerate development of next-generation targeted immune- and cell-based cancer therapies. He launched MD Anderson's Cancer Moon Shots Program, which became a model for the White House Cancer Moonshot funded by President
362:
Yao, Wantong; Brunetto, Emanuela; Kang, Ya'an; Yuan, Min; Asara, John M.; Wang, Y. Alan; Heffernan, Timothy P.; Kimmelman, Alec C.; Wang, Huamin; Fleming, Jason B.; Cantley, Lewis C.; DePinho, Ronald A.; Draetta, Giulio F. (30 October 2014).
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from 2011 to 2017. DePinho states that his concern for reducing the burden of cancer suffering became his life goal in 1998, when his father died of colon cancer.
254:. This work led to a deeper understanding of telomerase and telomere dysfunction in cancer, aging and a range of degenerative diseases, including fibrosis.
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Lee, HW; Blasco, MA; Gottlieb, GJ; Horner, JW; Greider, CW; DePinho, RA (April 1998). "Essential role of mouse telomerase in highly proliferative organs".
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Research
Professor in the Department of Medicine (Genetics) at Harvard Medical School. Previously, he held several faculty positions during 10 years at
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DePinho is best known for his work on telomerase and telomere disfunction as it relates to cancer and aging. Specifically, in collaboration with
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Genetic and biological mechanisms governing the development of cancer and driving the aging process and age-associated degenerative diseases.
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in 1955 to
Celeste and Alvaro DePinho. He is the third of five children. He earned a bachelor's degree in biological sciences in 1977 from
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He has published over 400 peer-reviewed research articles, review articles and book chapters (h-index 171). He was inducted into the
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process. He has constructed and used refined mouse models of cancer to identify many new cancer targets and diagnostics.
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187:-Presbyterian Medical Center, followed by postdoctoral fellowships in the Department of Cell Biology at
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604:"FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis"
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318:"Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth"
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647:"Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers"
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467:"Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism"
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172:. He received his medical degree with distinction in microbiology and immunology in 1981 from
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in New York, where he was the Betty and
Sheldon Feinberg Senior Scholar in Cancer Research.
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553:"p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation"
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416:"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway"
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questions of conflicts of interest, and unhappiness on the part of the faculty."
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152:(born 1955) is an American physician and research scientist. He served as president of
859:"DePinho resigns as MD Anderson president, acknowledges shortcomings as administrator"
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510:"FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis"
364:"Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function"
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Ellis Island Medal of Honor, National Ethnic
Coalition of Organizations (2017)
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Lowy, D; Singer, D; DePinho, R; Simon, GC; Soon-Shiong, P (9 June 2016).
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Maser, Richard S.; Choudhury, Bhudipa; et al. (June 2007).
1026:"Ronald A. DePinho, MD | AACR | Fellows of the AACR"
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Ying, Haoqiang; Kimmelman, Alec C.; et al. (April 2012).
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Paik, Ji-Hye; Kollipara, Ramya; et al. (January 2007).
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Zheng, Hongwu; Ying, Haoqiang; et al. (October 2008).
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Members of the United States
National Academy of Sciences
1040:"CidadĂŁos Estrangeiros Agraciados com Ordens Portuguesas"
729:"Physician Scientist Devoted to Reduce Cancer Suffering"
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Paik, Ji-hye; Ding, Zhihu; et al. (November 2009).
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and in the
Department of Biochemistry and Biophysics at
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Hu, Baoli; Wang, Qianghu; et al. (November 2016).
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University of Texas MD Anderson Cancer Center faculty
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Commanders of the Order of Saint James of the Sword
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42:
34:
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1044:Página Oficial das Ordens HonorĂficas Portuguesas
305:Honorary PhD Degree, Hofstra University (2017)
845:"Cancer Moonshot - National Cancer Institute"
8:
928:"Partial reversal of aging achieved in mice"
223:under the leadership of then-Vice President
179:He completed an internship and residency in
1128:Members of the National Academy of Medicine
994:The American Academy of Arts & Sciences
1093:Albert Einstein College of Medicine alumni
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275:American Association for Cancer Research
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831:"The Vice President's Cancer Moonshot"
267:American Academy of Arts and Sciences
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193:Columbia-Presbyterian Medical Center
414:Kimmelman, Alec C. (4 April 2013).
213:Albert Einstein College of Medicine
189:Albert Einstein College of Medicine
174:Albert Einstein College of Medicine
135:Albert Einstein College of Medicine
71:Albert Einstein College of Medicine
14:
293:Order of Saint James of the Sword
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711:"MD Anderson's Past Presidents"
1:
1012:National Academy of Sciences
976:National Academy of Medicine
271:National Academy of Sciences
263:National Academy of Medicine
205:Dana–Farber Cancer Institute
125:Dana–Farber Cancer Institute
1108:Fellows of the AACR Academy
1068:MD Anderson faculty profile
783:"Cancer moonshot countdown"
38:1955 (age 68–69)
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620:10.1016/j.cell.2006.12.029
526:10.1016/j.stem.2009.09.013
483:10.1016/j.cell.2012.01.058
335:10.1016/j.cell.2016.10.039
203:DePinho spent 14 years at
1088:Fordham University alumni
768:MD Anderson Cancer Center
747:"Ronald A. DePinho, M.D."
715:MD Anderson Cancer Center
247:, he generated the first
229:National Cancer Institute
154:MD Anderson Cancer Center
143:
120:MD Anderson Cancer Center
105:
25:
990:"Ronald Anthony DePinho"
164:DePinho was born in the
160:Early life and education
209:American Cancer Society
273:in 2012, and named an
130:Harvard Medical School
310:Selected publications
1083:American oncologists
787:Nature Biotechnology
328:(5): 1281–1295.e18.
227:and administered by
166:Bronx, New York City
1008:"Ronald A. DePinho"
972:"Ronald A. DePinho"
954:"Ronald A. DePinho"
890:1998Natur.392..569L
764:"Ronald A. DePinho"
671:10.1038/nature05886
663:2007Natur.447..966M
577:10.1038/nature07443
569:2008Natur.455.1129Z
563:(7216): 1129–1133.
440:10.1038/nature12040
432:2013Natur.496..101S
388:10.1038/nature13611
380:2014Natur.514..628V
934:. 28 November 2010
170:Fordham University
66:Fordham University
657:(7147): 966–971.
426:(7443): 101–105.
374:(7524): 628–632.
291:Commander of the
181:internal medicine
150:Ronald A. DePinho
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107:Scientific career
20:Ronald A. DePinho
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884:(6676): 569–74.
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847:. February 2016.
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733:Ron DePinho
51:Citizenship
43:Nationality
1077:Categories
1049:29 January
697:References
249:telomerase
92:Lynda Chin
225:Joe Biden
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689:17515920
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492:3472002
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608:Cell
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35:Born
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