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The hospital was run by Fred
Mtandah's CAPS Holdings, a Zimbabwean pharmaceutical company from 2004 to February 2016 when the hospital closed for refurbishments after some legal disputes between the catholic company and CAPS Holdings. In August 2020, St Anne's Hospital was opened as a
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response centre. In June 2021, the hospital was officially reopened for admissions and treatment of COVID patients and non-COVID-19 patients.
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The hospital has several sister hospitals around
Zimbabwe which include Mt St Mary's Hospital in
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