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Encephalopathy

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When referring to a finding, encephalopathy refers to permanent (or degenerative) brain injury, or a reversible one. It can be due to direct injury to the brain, or illness remote from the brain. The individual findings that cause a clinician to refer to a person as having encephalopathy include
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Carapancea, Evelina; Cornet, Marie-Coralie; Milh, Mathieu; De Cosmo, Lucrezia; Huang, Eric J.; Granata, Tiziana; Striano, Pasquale; Ceulemans, Berten; Stein, Anja; Morris-Rosendahl, Deborah; Conti, Greta; Mitra, Nipa; Raymond, F. Lucy; Rowitch, David H.; Solazzi, Roberta (2023-03-21).
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Treating the underlying cause of the disorder may improve or reverse symptoms. However, in some cases, the encephalopathy may cause permanent structural changes and irreversible damage to the brain. These permanent deficits can be considered a form of stable
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intellectual disability, irritability, agitation, delirium, confusion, somnolence, stupor, coma and psychosis. As such, describing a person as having a clinical picture of encephalopathy is not a very specific description.
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Depending on the type and severity of encephalopathy, common neurological symptoms are loss of cognitive function, subtle personality changes, and an inability to concentrate. Other neurological signs may include
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Diagnosis is frequently clinical. That is, no set of tests give the diagnosis, but the entire presentation of the illness with nonspecific test results informs the experienced clinician of the diagnosis.
1115: 2102: 2097: 2114: 2092: 302:: A collection of diseases all caused by prions, and characterized by "spongy" brain tissue (riddled with holes), impaired locomotion or coordination, and a 100% mortality rate. Includes 1265: 1138: 326:
encephalopathy: A form of encephalopathy caused by food poisoning (especially out of peanuts and rotten meat) often resulting in permanent brain damage and nervous system disorders.
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encephalopathy: Focal abnormalities of the white matter (generally area of low perfusion) are appreciated through magnetic resonance. Migraine is the most common symptom reported.
423: 1461: 758:"Long-term tracking of neurological complications of encephalopathy and myopathy in a patient with nephropathic cystinosis: a case report and review of the literature" 367:-associated encephalopathy (this type can occur in the setting of apparent sepsis, trauma, severe burns, or trauma, even without clear identification of an infection). 1456: 679:
When referring to a disease, encephalopathy refers to a wide variety of brain disorders with very different etiologies, prognoses and implications. For example,
320:(hypoxic-ischemic encephalopathy): An obstetric form, often occurring due to lack of oxygen in bloodflow to brain-tissue of the fetus during labour or delivery. 1258: 2084: 2195: 2074: 1251: 1134: 684: 299: 687:, are invariably fatal, but other encephalopathies are reversible and can have a number of causes including nutritional deficiencies and toxins. 2054: 1727: 560: 358: 2079: 1711: 1100: 1022: 995: 963: 933: 740: 1917: 1905: 1367: 1120: 156:: Metabolic disorder caused by dysfunction of mitochondrial DNA. Can affect many body systems, particularly the brain and nervous system. 2278: 672:
Encephalopathy is a difficult term because it can be used to denote either a disease or finding (i.e., an observable sign in a person).
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may be prescribed to reduce or halt any seizures. Changes to diet and nutritional supplements may help some people. In severe cases,
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encephalopathy: Arising from high levels of toxins normally cleared by the kidneys—rare where dialysis is readily available.
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can cause a severe encephalopathy (but it can be reversible with stopping use of the drug and starting the use of
2059: 2027: 1979: 1828: 1407: 503: 290:: A form of encephalopathy caused by chemicals and prescription drugs, often resulting in permanent brain damage. 1014:
American Psychiatric Association Practice Guidelines for the Treatment of Psychiatric Disorders: Compendium 2006
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Early infantile epileptic encephalopathy (acquired or congenital abnormal cortical development).
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conditions. In modern usage, encephalopathy does not refer to a single disease, but rather to a
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of overall brain dysfunction; this syndrome has many possible organic and inorganic causes.
67: 268:: A progressive degenerative disease associated with repeated head trauma, often linked to 1855: 1546: 611: 583: 812:"Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm" 896: 863: 442:. Characteristic of the altered mental state is impairment of the cognition, attention, 296:: A catch-all for brain dysfunction caused by infection, organ failure, or intoxication. 2245: 1912: 1861: 1689: 1275: 1066: 1039: 838: 811: 784: 757: 640: 607: 455: 415: 311: 269: 229: 810:
Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, et al. (2018).
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Treatment varies according to the type and severity of the encephalopathy.
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Encephalopathy: An ultra-rare autosomal recessive neonatal encephalopathy.
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is the most common autoimmune encephalitis. It can cause paranoid and
168:: A genetic metabolic disorder involving excess production of glycine. 1833: 1574: 1541: 1203: 491: 487: 388: 364: 253: 2089:
Spinal muscular atrophy with lower extremity predominance (SMALED)
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stops the progression of brain damage and improves the headaches.
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Office of Communications and Public Liaison (9 November 2010).
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There are many types of encephalopathy. Some examples include:
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Kaplan & Sadock's Concise Textbook of Clinical Psychiatry
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Manfred Oehmichen; Roland N. Auer; Hans Günter König (2006).
186:: Unchanging, or permanent, brain damage, usually caused by 106: 470:(involuntary twitching of a muscle or group of muscles) or 109: 103: 88: 82: 70: 553:(visual and auditory), bizarre behavior, fear, short-term 97: 947: 945: 236:, which is due to inborn errors of metabolism (including 756:
Müller M, Baumeier A, Ringelstein E, Husstedt I (2008).
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can cause posterior reversible encephalopathy syndrome.
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National Institute of Neurological Disorders and Stroke
928:(3rd ed.). McGraw Hill Professional. p. 438. 329:
Encephalomyopathy: A combination of encephalopathy and
162:, rare disease that occurs following a viral infection. 958:. Springer Science & Business Media. p. 611. 805: 803: 539:(invented memories), poor recall and disorientation. 458:
may be present; with or without: cognitive deficits,
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encephalopathy (possibly due to metabolic disorders).
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can cause a permanent severe global encephalopathy.
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Focal neurological deficits are less common. 355:(CJD; transmissible spongiform encephalopathy). 174:: Arising from advanced cirrhosis of the liver. 731:The British Medical Association (BMA) (2002). 2189: 1259: 248:, deficiencies of specific nutrients such as 8: 979: 977: 975: 614:or organ replacement surgery may be needed. 506:(cyclic waxing and waning of tidal volume), 2196: 2182: 2174: 1984: 1975: 1744: 1412: 1403: 1292: 1266: 1252: 1244: 1182: 735:. A Dorling Kindersley Book. p. 199. 525:co-occur with Korsakoff alcoholic syndrome 39: 1065: 1055: 1017:. American Psychiatric Pub. p. 210. 1011:American Psychiatric Association (2006). 926:Harrison's Neurology in Clinical Medicine 895: 837: 827: 783: 773: 685:transmissible spongiform encephalopathies 1135:"NINDS Encephalopathy Information Page" 723: 300:Transmissible spongiform encephalopathy 232:: A condition caused by high levels of 220:: Arising from an auto-immune disorder. 2055:Distal hereditary motor neuronopathies 1728:Template:Demyelinating diseases of CNS 1038:Bost C, Pascual O, Honnorat J (2016). 664:. Some encephalopathies can be fatal. 406:Chemotherapy medication, for example, 434:The hallmark of encephalopathy is an 7: 1906:Idiopathic intracranial hypertension 2279:Multiple organ dysfunction syndrome 498:(rapid, involuntary eye movement), 244:), a diet with excessive levels of 2137:Infantile progressive bulbar palsy 987:A Dictionary of Neurological Signs 25: 1840:Template:Cerebrovascular diseases 1643:Frontotemporal lobar degeneration 1860:For more detailed coverage, see 1838:For more detailed coverage, see 1809:For more detailed coverage, see 1775:For more detailed coverage, see 1726:For more detailed coverage, see 1168:The Diagnosis of Stupor and Coma 304:bovine spongiform encephalopathy 266:Chronic traumatic encephalopathy 160:Acute necrotizing encephalopathy 66: 27:Disorder or disease of the brain 632:, chronic infections, strokes, 543:Anti-NMDA receptor encephalitis 242:multiple carboxylase deficiency 224:Anti-NMDA receptor encephalitis 178:Hypoxic ischemic encephalopathy 733:Illustrated Medical Dictionary 294:Toxic-metabolic encephalopathy 226:: An auto-immune encephalitis. 1: 2153:Amyotrophic lateral sclerosis 2038:Hereditary spastic paraplegia 1896:Normal pressure hydrocephalus 1143:National Institutes of Health 683:diseases, all of which cause 645:non-celiac gluten sensitivity 2122:Progressive muscular atrophy 1121:Dorland's Medical Dictionary 880:10.1212/WNL.0000000000206755 586:(also known as spinal tap), 210:, usually in the setting of 188:prenatal exposure to ethanol 154:Mitochondrial encephalopathy 1632:Primary progressive aphasia 260:Hypertensive encephalopathy 2316: 1954:Hashimoto's encephalopathy 1660:Posterior cortical atrophy 1481:Striatonigral degeneration 1332:Cavernous sinus thrombosis 402:Toxicity from chemotherapy 218:Hashimoto's encephalopathy 122: 29: 2060:Spinal muscular atrophies 2028:Primary lateral sclerosis 1886:Intracranial hypertension 1666:Creutzfeldt–Jakob disease 990:. Springer. p. 112. 504:Cheyne-Stokes respiration 353:Creutzfeldt–Jakob disease 200:Wernicke's encephalopathy 2127:Progressive bulbar palsy 1918:Intracranial hypotension 1901:Choroid plexus papilloma 1315:Herpesviral encephalitis 1044:Neuropsychiatr Dis Treat 829:10.3748/wjg.v24.i14.1521 30:Not to be confused with 1639:Frontotemporal dementia 1325:Encephalitis lethargica 775:10.1186/1752-1947-2-235 521:Wernicke encephalopathy 318:Neonatal encephalopathy 1944:Hepatic encephalopathy 712:Psychoorganic syndrome 592:electroencephalography 508:apneustic respirations 172:Hepatic encephalopathy 166:Glycine encephalopathy 2002:Ataxia–telangiectasia 1959:Static encephalopathy 1682:Mitochondrial disease 1520:Spasmodic torticollis 1430:Basal ganglia disease 816:World J Gastroenterol 707:Neurological disorder 618:Sympathomimetic drugs 335:mitochondrial disease 333:. Causes may include 184:Static encephalopathy 133:, especially chronic 18:Static encephalopathy 1949:Toxic encephalopathy 1655:Lewy bodies dementia 1170:by Plum and Posner, 984:A.J. Larner (2016). 436:altered mental state 288:Toxic encephalopathy 281:Borrelia burgdorferi 2224:Respiratory failure 1997:Friedreich's ataxia 1380:Meningoencephalitis 1320:Limbic encephalitis 874:(12): e1234–e1247. 580:cerebrospinal fluid 547:grandiose delusions 533:anterograde amnesia 381:myoclonic epileptic 306:(mad cow disease), 276:Lyme encephalopathy 256:, or organ failure. 238:urea cycle disorder 2033:Pseudobulbar palsy 1771:Status epilepticus 1722:Multiple sclerosis 1559:Myoclonic epilepsy 1422:movement disorders 1368:Acute disseminated 1310:Viral encephalitis 1057:10.2147/NDT.S82380 561:HIV encephalopathy 529:retrograde amnesia 464:epileptic seizures 430:Signs and symptoms 373:encephalopathies: 359:HIV encephalopathy 345:, as may occur in 2287: 2286: 2171: 2170: 2167: 2166: 2163: 2162: 1967: 1966: 1872: 1871: 1811:Template:Headache 1777:Template:Epilepsy 1698: 1697: 1672:Vascular dementia 1515:Status dystonicus 1388: 1387: 1363:Encephalomyelitis 1241: 1240: 1102:978-0-7817-8746-8 1024:978-0-89042-385-1 997:978-3-319-29821-4 965:978-3-540-28995-1 935:978-0-07-181501-7 822:(14): 1521–1530. 742:978-0-75-133383-1 557:, and confusion. 59: 58: 37:Medical condition 16:(Redirected from 2307: 2198: 2191: 2184: 2175: 1985: 1976: 1934:Brain herniation 1745: 1585:Intention tremor 1580:Essential tremor 1445:Postencephalitic 1413: 1404: 1293: 1274:Diseases of the 1268: 1261: 1254: 1245: 1183: 1157: 1155: 1154: 1145:. Archived from 1124: 1116:"encephalopathy" 1113: 1107: 1106: 1086: 1080: 1079: 1069: 1059: 1035: 1029: 1028: 1008: 1002: 1001: 981: 970: 969: 949: 940: 939: 921: 910: 909: 899: 858: 852: 851: 841: 831: 807: 798: 797: 787: 777: 753: 747: 746: 728: 649:gluten-free diet 512:post-hypercapnic 448:sleep–wake cycle 343:hypophosphatemia 124: 116: 115: 112: 111: 108: 105: 102: 99: 96: 93: 90: 87: 84: 81: 78: 75: 72: 40: 21: 2315: 2314: 2310: 2309: 2308: 2306: 2305: 2304: 2300:Brain disorders 2290: 2289: 2288: 2283: 2267: 2207: 2202: 2172: 2159: 2085:Congenital DSMA 2006: 1963: 1922: 1868: 1856:Sleep disorders 1844: 1821:Cerebrovascular 1815: 1781: 1738: 1732: 1694: 1676: 1601: 1547:Choreoathetosis 1420: 1397: 1384: 1348: 1282: 1272: 1242: 1237: 1236: 1194: 1164: 1162:Further reading 1152: 1150: 1132: 1128: 1127: 1114: 1110: 1103: 1088: 1087: 1083: 1037: 1036: 1032: 1025: 1010: 1009: 1005: 998: 983: 982: 973: 966: 951: 950: 943: 936: 923: 922: 913: 860: 859: 855: 809: 808: 801: 755: 754: 750: 743: 730: 729: 725: 720: 693: 670: 657: 608:Anticonvulsants 604: 584:lumbar puncture 582:examination by 573: 432: 404: 207: 202:: Arising from 147: 69: 65: 38: 35: 28: 23: 22: 15: 12: 11: 5: 2313: 2311: 2303: 2302: 2292: 2291: 2285: 2284: 2282: 2281: 2275: 2273: 2269: 2268: 2266: 2265: 2263:Encephalopathy 2260: 2259: 2258: 2253: 2243: 2242: 2241: 2236: 2226: 2221: 2215: 2213: 2209: 2208: 2203: 2201: 2200: 2193: 2186: 2178: 2169: 2168: 2165: 2164: 2161: 2160: 2158: 2157: 2156: 2155: 2144: 2143: 2142: 2141: 2140: 2139: 2134: 2124: 2119: 2118: 2117: 2112: 2107: 2106: 2105: 2100: 2095: 2087: 2082: 2077: 2072: 2067: 2057: 2043: 2042: 2041: 2040: 2035: 2030: 2016: 2014: 2008: 2007: 2005: 2004: 1999: 1993: 1991: 1982: 1973: 1969: 1968: 1965: 1964: 1962: 1961: 1956: 1951: 1946: 1941: 1936: 1930: 1928: 1924: 1923: 1921: 1920: 1915: 1913:Cerebral edema 1910: 1909: 1908: 1903: 1898: 1893: 1882: 1880: 1874: 1873: 1870: 1869: 1867: 1866: 1865: 1864: 1862:Template:Sleep 1852: 1850: 1846: 1845: 1843: 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1186:Classification 1180: 1179: 1163: 1160: 1159: 1158: 1131:Adapted from: 1126: 1125: 1108: 1101: 1081: 1030: 1023: 1003: 996: 971: 964: 941: 934: 911: 853: 799: 762:J Med Case Rep 748: 741: 722: 721: 719: 716: 715: 714: 709: 704: 699: 692: 689: 669: 666: 656: 653: 641:celiac disease 603: 600: 572: 569: 551:hallucinations 537:confabulations 456:Hypervigilance 431: 428: 416:methylene blue 403: 400: 399: 398: 392: 386: 385: 384: 377: 368: 362: 356: 350: 337:(particularly 327: 321: 315: 297: 291: 285: 273: 270:contact sports 263: 257: 230:Hyperammonemia 227: 221: 215: 205: 197: 191: 181: 175: 169: 163: 157: 146: 143: 62:Encephalopathy 57: 56: 51: 45: 44: 43:Encephalopathy 36: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2312: 2301: 2298: 2297: 2295: 2280: 2277: 2276: 2274: 2270: 2264: 2261: 2257: 2254: 2252: 2249: 2248: 2247: 2246:Renal failure 2244: 2240: 2237: 2235: 2232: 2231: 2230: 2229:Liver failure 2227: 2225: 2222: 2220: 2219:Heart failure 2217: 2216: 2214: 2210: 2206: 2205:Organ failure 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646: 642: 637: 635: 631: 627: 623: 620:can increase 619: 615: 613: 609: 601: 599: 595: 593: 589: 588:brain imaging 585: 581: 577: 570: 568: 566: 562: 558: 556: 552: 549:, agitation, 548: 544: 540: 538: 534: 530: 526: 522: 518: 516: 513: 509: 505: 501: 497: 493: 489: 485: 481: 475: 473: 469: 465: 461: 457: 453: 452:consciousness 449: 445: 441: 437: 429: 427: 425: 421: 417: 413: 409: 401: 396: 393: 390: 387: 382: 378: 375: 374: 372: 369: 366: 363: 360: 357: 354: 351: 348: 344: 341:) or chronic 340: 336: 332: 328: 325: 322: 319: 316: 314:among others. 313: 309: 305: 301: 298: 295: 292: 289: 286: 283: 282: 277: 274: 271: 267: 264: 261: 258: 255: 251: 247: 243: 239: 235: 231: 228: 225: 222: 219: 216: 213: 209: 201: 198: 195: 192: 189: 185: 182: 179: 176: 173: 170: 167: 164: 161: 158: 155: 152: 151: 150: 144: 142: 140: 136: 132: 128: 120: 119:Ancient Greek 114: 63: 55: 52: 50: 46: 41: 33: 19: 2262: 2147: 2046: 2019: 1980:Degenerative 1717:Inflammatory 1664: 1597:Stiff-person 1435:Parkinsonism 1408:Degenerative 1398: 1305:Encephalitis 1288:Inflammation 1278:, primarily 1225: 1213: 1198: 1167: 1151:. Retrieved 1147:the original 1119: 1111: 1091: 1084: 1047: 1043: 1033: 1013: 1006: 986: 954: 925: 871: 867: 856: 819: 815: 765: 761: 751: 732: 726: 702:Neuroscience 697:Brain damage 678: 674: 671: 658: 638: 634:brain tumors 630:brain injury 616: 605: 596: 574: 563:can lead to 559: 541: 519: 476: 433: 405: 394: 279: 208:) deficiency 148: 135:degenerative 61: 60: 2132:Fazio–Londe 1972:Both/either 1766:Generalised 1625:Early-onset 1620:Alzheimer's 1355:spinal cord 668:Terminology 576:Blood tests 555:memory loss 500:jactitation 444:orientation 420:Bevacizumab 408:fludarabine 204:thiamine (B 32:Anencephaly 1740:paroxysmal 1712:Autoimmune 1505:Dyskinesia 1375:Meningitis 1353:Brain and 1153:2005-09-01 818:(Review). 718:References 622:motivation 480:dysarthria 422:and other 412:Ifosfamide 347:cystinosis 324:Salmonella 212:alcoholism 1737:Episodic/ 1615:Tauopathy 1566:Akathisia 1554:Myoclonus 1537:Athetosis 1469:Tauopathy 888:1526-632X 868:Neurology 655:Prognosis 626:cognition 602:Treatment 590:studies, 571:Diagnosis 496:nystagmus 484:hypomimia 472:asterixis 468:myoclonus 371:Epileptic 123:ἐγκέφαλος 54:Neurology 49:Specialty 2294:Category 2272:Multiple 2103:SMALED2B 2098:SMALED2A 1795:Migraine 1787:Headache 1753:epilepsy 1749:Seizures 1607:Dementia 1510:Dystonia 1222:: 348.30 1076:27822050 906:36599696 897:10033164 848:29662290 794:18644104 691:See also 662:dementia 612:dialysis 565:dementia 460:headache 440:delirium 331:myopathy 250:arginine 139:syndrome 2256:Chronic 2239:Chronic 2212:General 2115:SMA-PME 2110:SMA-PCH 2093:SMALED1 1805:Tension 1800:Cluster 1525:Meige's 1342:Amoebic 1232:D001927 1067:5089825 839:5897856 785:2491650 768:: 235. 308:scrapie 246:protein 234:ammonia 129:of the 127:disease 117:; from 1834:Stroke 1648:Pick's 1575:Tremor 1542:Chorea 1174:  1099:  1074:  1064:  1021:  994:  962:  932:  904:  894:  886:  846:  836:  792:  782:  739:  647:, the 492:tremor 488:ataxia 389:Gluten 379:Early 365:Sepsis 310:, and 254:biotin 194:Uremic 2251:Acute 2234:Acute 2148:both: 2080:DSMA1 2075:SMAX2 2070:SMAX1 2050:only: 2023:only: 1927:Other 1849:Other 1761:Focal 1394:Brain 1297:Brain 1209:G93.4 681:prion 515:apnea 395:BRAT1 339:MELAS 145:Types 131:brain 1751:and 1462:PKAN 1457:NBIA 1227:MeSH 1219:9-CM 1172:ISBN 1097:ISBN 1072:PMID 1019:ISBN 992:ISBN 960:ISBN 930:ISBN 902:PMID 884:ISSN 844:PMID 790:PMID 737:ISBN 523:can 510:and 450:and 312:kuru 2065:SMA 2048:LMN 2021:UMN 2012:MND 1878:CSF 1829:TIA 1474:PSP 1450:NMS 1419:and 1280:CNS 1215:ICD 1200:ICD 1118:at 1062:PMC 1052:doi 892:PMC 876:doi 872:100 834:PMC 824:doi 780:PMC 770:doi 643:or 438:or 418:). 252:or 240:or 2296:: 1989:SA 1496:OA 1491:HD 1440:PD 1230:: 1207:: 1204:10 1141:, 1137:. 1070:. 1060:. 1048:12 1046:. 1042:. 974:^ 944:^ 914:^ 900:. 890:. 882:. 870:. 866:. 842:. 832:. 820:24 814:. 802:^ 788:. 778:. 764:. 760:. 636:. 624:, 578:, 567:. 535:, 531:, 490:, 482:, 466:, 462:, 446:, 121:: 2197:e 2190:t 2183:v 1641:/ 1396:/ 1267:e 1260:t 1253:v 1217:- 1202:- 1192:D 1156:. 1105:. 1078:. 1054:: 1027:. 1000:. 968:. 938:. 908:. 878:: 850:. 826:: 796:. 772:: 766:2 745:. 349:. 284:. 272:. 214:. 206:1 190:. 113:/ 110:i 107:θ 104:ə 101:p 98:ɒ 95:l 92:ˈ 89:ə 86:f 83:ɛ 80:s 77:ˌ 74:n 71:ɛ 68:/ 64:( 34:. 20:)

Index

Static encephalopathy
Anencephaly
Specialty
Neurology
/ɛnˌsɛfəˈlɒpəθi/
Ancient Greek
disease
brain
degenerative
syndrome
Mitochondrial encephalopathy
Acute necrotizing encephalopathy
Glycine encephalopathy
Hepatic encephalopathy
Hypoxic ischemic encephalopathy
Static encephalopathy
prenatal exposure to ethanol
Uremic
Wernicke's encephalopathy
thiamine (B1) deficiency
alcoholism
Hashimoto's encephalopathy
Anti-NMDA receptor encephalitis
Hyperammonemia
ammonia
urea cycle disorder
multiple carboxylase deficiency
protein
arginine
biotin

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