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Health
Sciences Institute, where he began studying the physical chemistry of protein-nucleic interactions. He began his academic research career at Northwestern University Medical School in 1981 and later moved to the University of California at Davis in 1991. He is one of the world's foremost
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243:, the defining member of a ubiquitous class of DNA strand-exchange proteins that are essential for homologous recombination, a pathway that maintains genomic integrity by repairing broken
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Singleton MR, Dillingham MS, Gaudier M, Kowalczykowski SC, Wigley DB (November 11, 2004). "Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks".
895:
885:
524:
Galletto R, Amitani I, Baskin RJ, Kowalczykowski SC (October 2019). "Direct observation of individual RecA filaments assembling on single DNA molecules".
210:. He calls this scientific approach, "visual biochemistry". Stephen Kowalczykowski was elected to the American Society for Arts and Science in 2005, the
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875:
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Stephen C. Kowalczykowski, who studies the molecular machines that copy and repair DNA, has been elected to the
National Academy of Sciences.
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in 1976. His dissertation title was "Physical-Chemistry studies of Sickle Cell
Hemoglobin." He then worked as a postdoctoral researcher with
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A few of his lab's notable scientific contributions include the structural and molecular mechanism of DNA end resection by RecBCD (
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106:
761:"Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes"
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Cejka P, Cannavo E, Polaczek P, Masuda-Sasa T, Pokharel S, Campbell JL, Kowalczykowski SC (September 2, 2010).
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810:"Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search"
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712:"Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3"
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275:), the purification and molecular mechanism of the human breast cancer susceptibility gene
469:"DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2"
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577:"Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA"
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263:) and DNA2-Sgs1-RPA and regulatory stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2 (
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Cejka P, Plank JL, Bachrati CZ, Hickson ID, Kowalczykowski SC (November 2010).
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in 2007 and was a Harvey
Society Lecturer at Rockefeller University in 2012.
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Cejka P, Plank JL, Dombrowski CC, Kowalczykowski SC (September 28, 2012).
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Bell JC, Plank JL, Dombrowski CC, Kowalczykowski SC (November 8, 2012).
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291:), and the mechanism of the 3-dimensional homology search catalyzed by
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182:. His research focuses on the biochemistry and molecular biology of
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251:, homologous recombination and the biophysics of DNA helicases.
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634:"Purified human BRCA2 stimulates RAD51-mediated recombination"
247:. His lab has made significant contributions to the fields of
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Jensen RB, Carreira A, Kowalczykowski SC (October 7, 2010).
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filament nucleation and growth and regulation by RecFOR (
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in 1972 and earned his Ph.D. in
Chemistry/Biochemistry at
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Members of the United States
National Academy of Sciences
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Fellows of the
American Academy of Arts and Sciences
222:Stephen Kowalczykowski studied chemistry (B.S.) at
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58:
40:
30:
23:
808:Forget AL, Kowalczykowski SC (February 8, 2012).
350:"Two Professors Elected to Prestigious Academies"
198:to manipulate and visualize single molecules of
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190:. His lab combines fluorescence microscopy,
174:("Steve K") is a Distinguished Professor of
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329:"UC Davis College of Biological Sciences"
896:Rensselaer Polytechnic Institute alumni
886:University of California, Davis faculty
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206:involved in processing and repairing
102:American Academy of Arts and Sciences
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176:Microbiology and Molecular Genetics
393:. November 6, 2007. Archived from
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287:helicase (BLM) homologue, Sgs1 (
180:University of California at Davis
144:University of California at Davis
881:21st-century American biologists
224:Rensselaer Polytechnic Institute
45:Rensselaer Polytechnic Institute
16:American biologist and professor
355:University of California, Davis
309:Research publications on Pubmed
279:(humans), the mechanism of the
172:Stephen Charles Kowalczykowski
1:
876:American molecular biologists
358:. May 3, 2007. Archived from
891:Georgetown University alumni
777:10.1016/j.molcel.2012.06.032
212:National Academy of Sciences
107:National Academy of Sciences
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87:single-molecule biophysics
385:"Department of Chemistry"
165:
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25:Stephen C. Kowalczykowski
871:American microbiologists
255:Scientific contributions
188:homologous recombination
67:homologous recombination
97:Harvey Society Lecturer
390:Georgetown University
228:Georgetown University
49:Georgetown University
236:University of Oregon
232:Dr. Peter von Hippel
218:Education and career
53:University of Oregon
834:10.1038/nature10782
826:2012Natur.482..423F
716:Nat Struct Mol Biol
658:10.1038/nature09399
650:2010Natur.467..678J
601:10.1038/nature11598
593:2012Natur.491..274B
546:10.1038/nature05197
538:2006Natur.443..875G
493:10.1038/nature09355
485:2010Natur.467..112C
438:10.1038/nature02988
430:2004Natur.432..187S
283:dissolution by the
267:), the kinetics of
397:on August 20, 2008
156:Jacinto Steinhardt
728:10.1038/nsmb.1919
281:Holliday junction
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130:Molecular Biology
115:Scientific career
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399:. Retrieved
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332:. Retrieved
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140:Institutions
126:Biochemistry
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239:experts on
31:Nationality
865:Categories
316:References
249:DNA repair
184:DNA repair
134:Biophysics
63:DNA repair
83:helicases
852:22318518
795:22885009
746:20935631
676:20729832
619:23103864
554:16988658
511:20811461
446:15538360
401:July 16,
366:July 16,
202:and the
124:"Visual
35:American
843:3288143
822:Bibcode
786:3462259
737:2988882
667:2952063
646:Bibcode
610:4112059
589:Bibcode
562:4416295
534:Bibcode
502:3089589
481:Bibcode
454:2916995
426:Bibcode
297:E. coli
273:E. coli
261:E. coli
234:at the
204:enzymes
178:at the
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581:Nature
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473:Nature
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418:Nature
121:Fields
109:(2007)
104:(2005)
99:(2012)
93:Awards
79:RecBCD
558:S2CID
450:S2CID
277:BRCA2
75:BRCA2
848:PMID
791:PMID
742:PMID
697:2013
672:PMID
615:PMID
550:PMID
507:PMID
442:PMID
403:2023
368:2023
336:2013
293:RecA
269:RecA
241:RecA
194:and
186:and
71:RecA
838:PMC
830:doi
818:482
781:PMC
773:doi
732:PMC
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597:doi
585:491
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245:DNA
208:DNA
200:DNA
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