1700:
276:
253:
1712:
150:
175:
1603:
1589:
2458:
527:
282:
181:
1686:
1559:
1573:
1905:
1871:
1424:. In addition to the 11β-hydroxylase activity, both isozymes have 18-hydroxylase activity. The CYP11B1 isozyme has strong 11β-hydroxylase activity, but the activity of 18-hydroxylase is only one-tenth of CYP11B2. The weak 18-hydroxylase activity of CYP11B1 explains why an adrenal with suppressed CYP11B2 expression continues to synthesize
1620:
As a mitochondrial P450 system, P450c11 is dependent on two electron transfer proteins, adrenodoxin reductase and adrenodoxin that transfer 2 electrons from NADPH to the P450 for each monooxygenase reaction catalyzed by the enzyme. In most respects this process of electron transfer appears similar to
1899:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and
3481:
Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES (July 1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes".
1363:. The product of this CYP11B1 gene is the 11β-hydroxylase protein. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of various steroids in the adrenal cortex. Transcript variants encoding different isoforms have been noted for this
1402:. The enzyme is primarily localized in the zona glomerulosa and zona fasciculata of the adrenal cortex. The enzyme functions by introducing a hydroxyl group at carbon position 11β on the steroid nucleus, thereby facilitating the conversion of certain steroids.
1900:
is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
1625:
system that catalyzes cholesterol side chain cleavage. Similar to P450scc the process of electrons transfer is leaky leading to superoxide production. The rate of electron leakage during metabolism depends on the functional groups of the steroid substrate.
1875:
4206:
1647:
3519:
Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A (July 1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis".
1662:
3114:
Helmberg A, Ausserer B, Kofler R (November 1992). "Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency".
2567:
CYP11B1 and 2 have also been shown to 11β-hydroxylate T, yielding 11β-hydroxytestosterone (11OHT), though the levels produced by the adrenal are low due to the limited availability of adrenal derived T
1814:
Lifton RP, Dluhy RG, Powers M, Rich GM, Gutkin M, Fallo F, et al. (September 1992). "Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase".
1922:
Zöllner A, Kagawa N, Waterman MR, Nonaka Y, Takio K, Shiro Y, et al. (February 2008). "Purification and functional characterization of human 11beta hydroxylase expressed in
Escherichia coli".
3417:
Naiki Y, Kawamoto T, Mitsuuchi Y, Miyahara K, Toda K, Orii T, Imura H, Shizuta Y (December 1993). "A nonsense mutation (TGG -->TAG ) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency".
3292:
Kawamoto T, Mitsuuchi Y, Toda K, Miyahara K, Yokoyama Y, Nakao K, Hosoda K, Yamamoto Y, Imura H, Shizuta Y (September 1990). "Cloning of cDNA and genomic DNA for human cytochrome P-45011 beta".
2239:
van Rooyen D, Gent R, Barnard L, Swart AC (April 2018). "The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway".
4199:
5451:
4192:
289:
188:
5916:
6085:
3629:"Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1"
1242:
1699:
1261:
2994:"Best Practice for Identification of Classical 21-Hydroxylase Deficiency Should Include 21 Deoxycortisol Analysis with Appropriate Isomeric Steroid Separation"
5500:
1552:, by catalyzing the hydroxylation of carbon hydrogen bond at 11-beta position. Note the extra "–OH" added at the 11 position (near the center, on ring "C"):
2682:
Nicod J, Dick B, Frey FJ, Ferrari P (February 2004). "Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production".
6566:
5672:
97:
4576:
4571:
810:
791:
5654:
5650:
4813:
6561:
5339:
4402:
3964:
6652:
6234:
4348:
3857:
1965:
Dörr HG, Kuhnle U, Holthausen H, Bidlingmaier F, Knorr D (November 1984). "Etomidate: a selective adrenocortical 11 beta-hydroxylase inhibitor".
6320:
5923:
5632:
5156:
4766:
4516:
4032:
3771:
6893:
2544:
2094:
2019:
1796:
6129:
1778:
6878:
6078:
6019:
5576:
5492:
4285:
4184:
275:
5817:
5516:
4704:
4660:
4563:
4343:
3932:
3198:"Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans"
33:
1018:
6420:
6355:
4652:
4588:
1025:
252:
6365:
6190:
3905:
3145:"Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2"
2323:
Bulsari K, Falhammar H (January 2017). "Clinical perspectives in congenital adrenal hyperplasia due to 11β-hydroxylase deficiency".
5556:
1254:
6691:
6489:
6124:
5895:
6858:
6686:
6350:
6071:
5693:
5534:
5413:
5112:
4460:
4290:
3944:
3890:
1765:
1744:
2918:
1205:
6681:
6467:
6425:
5879:
5686:
4441:
1181:
2808:
1761:
1711:
3627:
Chabre O, Portrat-Doyen S, Chaffanjon P, Vivier J, Liakos P, Labat-Moleur F, Chambaz E, Morel Y, Defaye G (November 2000).
3196:
Kawamoto T, Mitsuuchi Y, Toda K, Yokoyama Y, Miyahara K, Miura S, Ohnishi T, Ichikawa Y, Nakao K, Imura H (February 1992).
174:
149:
5590:
5560:
5520:
5508:
4806:
4776:
4483:
4431:
4364:
3749:
3251:"A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin"
1487:
1740:
6271:
6213:
6103:
5744:
5658:
5646:
77:
3699:"Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia"
3664:"Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase"
2886:"Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells"
288:
187:
6325:
5796:
5496:
5164:
4771:
4325:
4173:
4022:
1588:
2727:"DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids?"
4791:
281:
180:
6499:
6494:
6298:
6164:
5679:
5618:
5614:
5602:
5598:
5594:
3764:
1654:
1602:
1497:
1473:
1467:
2835:"Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence"
6224:
5982:
5867:
5636:
4436:
4168:
4129:
4119:
4105:
4101:
4091:
4079:
4059:
4042:
4010:
3974:
3874:
3801:
1199:
6415:
6293:
6051:
5789:
5736:
5731:
5586:
5437:
4834:
4799:
4338:
3792:
3743:
1512:
1425:
1092:
855:
121:
85:
4014:
2862:
1186:
6462:
6249:
5838:
5711:
3805:
836:
3446:
Joehrer K, Geley S, Strasser-Wozak EM, Azziz R, Wollmann HA, Schmitt K, Kofler R, White PC (October 1997).
6457:
6114:
5665:
5610:
5606:
5572:
5504:
5086:
4407:
4153:
4069:
3818:
1594:
1545:
1448:
1266:
1174:
6831:
6571:
6447:
6283:
6261:
5902:
5408:
4369:
3949:
3922:
3757:
1634:
The expression of the enzyme in adrenocortical cells is regulated by the trophic hormone corticotropin (
3739:
2421:
3077:
Stowasser M, Gunasekera TG, Gordon RD (December 2001). "Familial varieties of primary aldosteronism".
6672:
6578:
6435:
6384:
6330:
5860:
5757:
5628:
5527:
5168:
4541:
4422:
4064:
4027:
3788:
3377:
3209:
3156:
2635:"Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects"
1674:
1417:
1391:
1109:
589:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
163:
3559:"Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells"
1202:
64:
6888:
6012:
5718:
5546:
4412:
4050:
3662:
Fisher A, Friel EC, Bernhardt R, Gomez-Sanchez C, Connell JM, Fraser R, Davies E (September 2001).
1286:
1126:
1104:
980:
929:
5360:
2042:
White PC, Curnow KM, Pascoe L (August 1994). "Disorders of steroid 11 beta-hydroxylase isozymes".
6602:
6370:
6244:
5512:
4727:
4243:
4235:
3813:
3545:
3507:
3448:"CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency"
3317:
3102:
2974:
2707:
2558:
2527:
Storbeck KH, Mostaghel EA (2019). "Canonical and
Noncanonical Androgen Metabolism and Activity".
2446:
2348:
2264:
2181:
Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW (February 2013).
2100:
1990:
1947:
1849:
1558:
1522:
109:
4613:
3959:
2478:"11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function"
2077:
White PC, Curnow KM, Pascoe L (1993). "Steroid 11β-Hydroxylase
Isozymes (CYP11B1 and CYP11B2)".
1001:
976:
950:
925:
2776:"Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta"
6592:
6395:
6176:
4738:
4668:
4333:
4314:
3847:
3720:
3685:
3650:
3615:
3580:
3537:
3499:
3469:
3434:
3405:
3352:
3309:
3280:
3237:
3184:
3131:
3094:
3065:
3025:
2966:
2910:
2854:
2800:
2756:
2699:
2664:
2633:
Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM (September 2004).
2612:
2550:
2540:
2509:
2402:
2340:
2305:
2256:
2212:
2154:
2090:
2059:
2015:
1982:
1939:
1841:
1193:
526:
57:
4990:
2992:
Greaves RF, Kumar M, Mawad N, Francescon A, Le C, O'Connell M, Chi J, Pitt J (October 2023).
2531:. Advances in Experimental Medicine and Biology. Vol. 1210. Springer. pp. 239–277.
2183:"Structural insights into aldosterone synthase substrate specificity and targeted inhibition"
2009:
105:
6883:
6405:
6198:
4859:
4746:
4266:
4219:
3710:
3675:
3640:
3605:
3594:"The C494F variant in the CYP11B1 gene is a sequence polymorphism in the Spanish population"
3570:
3529:
3491:
3459:
3426:
3395:
3385:
3342:
3301:
3270:
3262:
3227:
3217:
3174:
3164:
3143:
Pascoe L, Curnow KM, Slutsker L, Connell JM, Speiser PW, New MI, White PC (September 1992).
3123:
3086:
3057:
3015:
3005:
2956:
2900:
2846:
2790:
2746:
2738:
2691:
2654:
2646:
2602:
2592:
2532:
2499:
2489:
2436:
2392:
2384:
2332:
2295:
2248:
2202:
2194:
2144:
2134:
2082:
2051:
1974:
1931:
1831:
1823:
1658:
1564:
1537:
1477:
1438:
1294:
1290:
1162:
368:
299:
243:
198:
127:
3331:"Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)"
17:
6310:
6203:
5961:
4830:
4498:
3937:
2462:
2457:
1689:
1483:
1340:
1320:
1138:
343:
1097:
3381:
3213:
3160:
3020:
2993:
2461: This article incorporates text from this source, which is available under the
5269:
4608:
4527:
4306:
4163:
4143:
4138:
3780:
2751:
2726:
2659:
2634:
2607:
2580:
2504:
2477:
2397:
2372:
2207:
2182:
2149:
2126:
1608:
1572:
1549:
1508:
1452:
1421:
1324:
1298:
1237:
3400:
3365:
3347:
3330:
3275:
3250:
3048:
Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes".
2905:
2795:
1217:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
634:
629:
624:
619:
603:
598:
593:
588:
583:
578:
573:
568:
6872:
6094:
6044:
5948:
5909:
5831:
5824:
5810:
5770:
5751:
5725:
3575:
3558:
3511:
3305:
3232:
3197:
3179:
3144:
3090:
2978:
2562:
2450:
1935:
1909:
1431:
Here are some of the steroids, grouped by catalytic activity of the CYP11B1 isozyme:
1348:
1317:
1212:
555:
3321:
3106:
2352:
2300:
2283:
2104:
2081:. Handbook of Experimental Pharmacology. Vol. 105. Springer. pp. 641–650.
1994:
1951:
6727:
6702:
6360:
6239:
6152:
5567:
5541:
5445:
5431:
5424:
5330:
5310:
5303:
5286:
5228:
5211:
5204:
5197:
5190:
5183:
5151:
5144:
4508:
3982:
3978:
3549:
2885:
2268:
1493:
1463:
361:
140:
3592:
Loidi L, Quinteiro C, Barros F, Domínguez F, Barreiro J, Pombo M (December 1999).
2711:
2371:
Turcu AF, Rege J, Chomic R, Liu J, Nishimoto HK, Else T, et al. (June 2015).
1853:
89:
2775:
2536:
2086:
113:
5137:
5093:
4624:
4536:
4451:
4384:
4295:
4277:
4227:
2252:
1801:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1783:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1352:
1221:
2597:
2494:
444:
6479:
6141:
4822:
4394:
4215:
4114:
3610:
3593:
3430:
3127:
2695:
2336:
1685:
1395:
1379:
260:
157:
93:
2945:"Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol"
1881:"Entrez Gene: CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1"
6410:
6037:
5238:
4826:
4732:
4699:
4553:
4475:
4083:
4046:
3990:
3784:
3645:
3628:
3464:
3447:
3390:
3169:
2441:
2139:
1375:
755:
504:
382:
327:
314:
226:
213:
101:
68:, CPN1, CYP11B, FHI, P450C11, cytochrome P450 family 11 subfamily B member 1
3724:
3715:
3698:
3689:
3680:
3663:
3654:
3619:
3584:
3541:
3503:
3222:
3098:
3061:
3029:
2970:
2850:
2760:
2703:
2668:
2616:
2554:
2513:
2406:
2344:
2309:
2260:
2216:
2158:
1943:
3473:
3438:
3409:
3364:
Chua SC, Szabo P, Vitek A, Grzeschik KH, John M, White PC (October 1987).
3356:
3313:
3284:
3249:
White PC, Dupont J, New MI, Leiberman E, Hochberg Z, Rösler A (May 1991).
3241:
3188:
3135:
3069:
2914:
2858:
2804:
2063:
2055:
1986:
1845:
1412:
CYP11B1 (11β-hydroxylase) is expressed at high levels and is regulated by
1351:
that catalyze many reactions involved in drug metabolism and synthesis of
1065:
1060:
6556:
6430:
6063:
5994:
5954:
5941:
5886:
5853:
5803:
5781:
5776:
5762:
4691:
4634:
4549:
4261:
3862:
2650:
2388:
2198:
1880:
1578:
1541:
1518:
1442:
1150:
1049:
900:
881:
3010:
2742:
1836:
6716:
6711:
6631:
5463:
5390:
5380:
5370:
5353:
5343:
5335:
5323:
5319:
5315:
5296:
5248:
5221:
5176:
5172:
5160:
5051:
5046:
5041:
5016:
5011:
4995:
4915:
4910:
4890:
4757:
4752:
4647:
4642:
4558:
4488:
4253:
4231:
4158:
1978:
1622:
1406:
1399:
1356:
1306:
1169:
867:
822:
3266:
2961:
2944:
1827:
6821:
6816:
6786:
6781:
6661:
6641:
6636:
6626:
6621:
6616:
6611:
5130:
5126:
5116:
5102:
5098:
5066:
5061:
5056:
5036:
5031:
5026:
5021:
4985:
4980:
4975:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4920:
4905:
4900:
4895:
4885:
4880:
4864:
4854:
4849:
4678:
4673:
4601:
4596:
4223:
4000:
3995:
3954:
2725:
Lenders JW, Williams TA, Reincke M, Gomez-Sanchez CE (January 2018).
1885:
1344:
1249:
1145:
1133:
1121:
1033:
777:
2834:
1536:
11β-hydroxylase has strong catalytic activity during conversion of
6841:
6836:
6826:
6811:
6806:
6801:
6796:
6791:
6776:
6771:
6766:
6761:
6756:
6751:
6746:
6741:
6736:
6532:
6519:
5417:
5279:
4966:
4147:
3882:
3840:
3833:
3828:
3823:
3533:
3495:
1684:
1360:
1908:
This article incorporates text from this source, which is in the
740:
736:
5471:
3927:
3915:
3910:
3900:
3895:
3878:
3852:
3366:"Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11)"
1648:
congenital adrenal hyperplasia due to 11β-hydroxylase deficiency
1646:
A mutation in genes encoding 11β-hydroxylase is associated with
1635:
1413:
1364:
1313:
1157:
81:
6067:
4795:
4188:
3753:
1663:
congenital adrenal hyperplasia due to 21-hydroxylase deficiency
535:
2373:"Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency"
2581:"11-Keto-testosterone and other androgens of adrenal origin"
2476:
Bloem LM, Storbeck KH, Schloms L, Swart AC (October 2013).
2884:
Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990).
1692:, showing steroid 11-beta-hydroxylase vertically at right.
2241:
The
Journal of Steroid Biochemistry and Molecular Biology
1420:) is usually expressed at low levels and is regulated by
3697:
Hampf M, Dao NT, Hoan NT, Bernhardt R (September 2001).
351:
3329:
Mornet E, Dupont J, Vitek A, White PC (December 1989).
516:
4706:
4662:
4654:
4590:
4565:
2639:
The
Journal of Clinical Endocrinology and Metabolism
2377:
The
Journal of Clinical Endocrinology and Metabolism
2288:
1409:
with 11β-hydroxylase activity: CYP11B1 and CYP11B2.
6725:
6700:
6670:
6650:
6600:
6591:
6545:
6508:
6476:
6444:
6392:
6383:
6339:
6307:
6280:
6258:
6221:
6212:
6189:
6161:
6138:
6111:
6102:
6029:
6004:
5933:
5703:
5481:
5400:
5258:
5075:
5004:
4964:
4873:
4842:
4720:
4689:
4632:
4622:
4525:
4506:
4497:
4473:
4450:
4421:
4392:
4382:
4357:
4323:
4304:
4276:
4251:
4242:
4128:
4100:
4078:
4041:
4009:
3973:
3873:
3800:
1260:
1248:
1236:
1231:
1211:
1192:
1180:
1168:
1156:
1144:
1132:
1120:
1115:
1103:
1091:
1086:
1081:
994:
969:
943:
918:
2774:Hanukoglu I, Privalle CT, Jefcoate CR (May 1981).
2282:Mello, Penachioni, Amaral, Castro (October 2004).
1757:
1755:
1753:
1736:
1734:
1732:
2014:. Lippincott Williams & Wilkins. p. 68.
1653:11β-hydroxylase is involved in the metabolism of
298:
197:
1316:. The enzyme is involved in the biosynthesis of
2833:Rapoport R, Sklan D, Hanukoglu I (March 1995).
2628:
2626:
2579:Stárka L, Dušková M, Vítků J (September 2020).
2366:
2364:
2362:
2234:
2232:
2230:
2228:
2226:
2176:
2174:
2172:
2170:
2168:
2120:
2118:
2116:
2114:
1889:. National Center for Biotechnology Information
2131:Indian Journal of Endocrinology and Metabolism
1762:GRCm38: Ensembl release 89: ENSMUSG00000022589
1339:gene encodes 11β-hydroxylase, a member of the
6079:
4807:
4200:
3765:
721:cellular response to peptide hormone stimulus
8:
1741:GRCh38: Ensembl release 89: ENSG00000160882
6597:
6567:Mitochondrial permeability transition pore
6549:
6389:
6218:
6108:
6086:
6072:
6064:
4814:
4800:
4792:
4629:
4503:
4389:
4248:
4207:
4193:
4185:
3772:
3758:
3750:
1705:Corticosteroid biosynthetic pathway in rat
1228:
751:
551:
339:
238:
135:
3742:at the U.S. National Library of Medicine
3714:
3679:
3644:
3609:
3574:
3463:
3399:
3389:
3346:
3274:
3231:
3221:
3178:
3168:
3019:
3009:
2960:
2904:
2794:
2750:
2658:
2606:
2596:
2503:
2493:
2440:
2396:
2299:
2206:
2148:
2138:
1835:
6562:Mitochondrial membrane transport protein
4403:Farnesyl-diphosphate farnesyltransferase
1865:
1863:
676:C21-steroid hormone biosynthetic process
574:corticosterone 18-monooxygenase activity
4349:Isopentenyl-diphosphate delta isomerase
1728:
1695:
1584:
1554:
6321:Cholesterol side-chain cleavage enzyme
4767:Steroidogenic acute regulatory protein
2924:from the original on 16 September 2012
2814:from the original on 16 September 2012
2420:Masiutin MM, Yadav MK (3 April 2023).
1532:Cortisol and corticosterone metabolism
1078:
599:steroid 11-beta-monooxygenase activity
38:
681:cellular response to hormone stimulus
303:
264:
259:
202:
161:
156:
7:
3965:24-hydroxycholesterol 7α-hydroxylase
2684:Molecular and Cellular Endocrinology
6235:Coenzyme Q – cytochrome c reductase
4344:Pyrophosphomevalonate decarboxylase
4262:Acetyl-Coenzyme A acetyltransferase
1347:. The cytochrome P450 proteins are
1303:cytochrome P450 11B1, mitochondrial
686:glucocorticoid biosynthetic process
6421:Oxoglutarate dehydrogenase complex
6356:Glycerol-3-phosphate dehydrogenase
1394:, i.e. the enzyme involved in the
991:
966:
940:
915:
891:
872:
846:
827:
801:
782:
701:cellular response to potassium ion
521:
439:
377:
356:
25:
6366:Carnitine palmitoyltransferase II
3557:Cao PR, Bernhardt R (June 1999).
2731:European Journal of Endocrinology
1309:that in humans is encoded by the
6490:Carbamoyl phosphate synthetase I
6130:Long-chain-fatty-acid—CoA ligase
6125:Carnitine palmitoyltransferase I
3576:10.1046/j.1432-1327.1999.00414.x
3091:10.1046/j.1440-1681.2001.03574.x
2865:from the original on 20 May 2020
2456:
2127:"Mineralocorticoid hypertension"
1936:10.1111/j.1742-4658.2008.06253.x
1903:
1874: This article incorporates
1869:
1710:
1698:
1601:
1587:
1571:
1557:
1374:gene is reversibly inhibited by
661:aldosterone biosynthetic process
525:
459:lumbar subsegment of spinal cord
287:
280:
274:
251:
186:
179:
173:
148:
34:11β-Hydroxysteroid dehydrogenase
6351:Glutamate aspartate transporter
4517:Cholesterol side-chain cleavage
4461:24-Dehydrocholesterol reductase
4291:3-hydroxybutyrate dehydrogenase
3945:Cholesterol 7 alpha-hydroxylase
3891:Flavin-containing monooxygenase
2949:Hormone Research in Paediatrics
2422:"Alternative androgen pathways"
2301:10.1590/s0004-27302004000500018
2284:"11beta-hydroxylase deficiency"
6468:Pyruvate dehydrogenase complex
6426:Succinyl coenzyme A synthetase
4442:7-Dehydrocholesterol reductase
1323:by catalyzing the addition of
536:More reference expression data
505:More reference expression data
1:
4777:Reverse cholesterol transport
4365:Dimethylallyltranstransferase
3348:10.1016/S0021-9258(19)30030-4
3079:Clin. Exp. Pharmacol. Physiol
2906:10.1016/S0021-9258(17)30545-8
2796:10.1016/S0021-9258(19)69437-8
1886:Reference Sequence collection
716:cholesterol metabolic process
666:cortisol biosynthetic process
272:
171:
6894:Steroid hormone biosynthesis
6272:Dihydroorotate dehydrogenase
3370:Proc. Natl. Acad. Sci. U.S.A
3306:10.1016/0014-5793(90)81190-Y
3202:Proc. Natl. Acad. Sci. U.S.A
3149:Proc. Natl. Acad. Sci. U.S.A
2537:10.1007/978-3-030-32656-2_11
2133:. 15 Suppl 4 (8): S298–312.
2087:10.1007/978-3-642-77763-9_41
2011:Pediatric Cardiac Anesthesia
1327:during oxidation reactions.
706:steroid biosynthetic process
671:regulation of blood pressure
635:mitochondrial inner membrane
6879:Genes on human chromosome 8
6326:Steroid 11-beta-hydroxylase
4772:Cholesterol total synthesis
4174:Deoxyhypusine monooxygenase
3740:Steroid+11-beta-hydroxylase
2253:10.1016/j.jsbmb.2017.12.014
2008:Lake CL (7 December 2004).
18:Steroid 11-beta-hydroxylase
6910:
6500:N-Acetylglutamate synthase
6495:Ornithine transcarbamylase
6299:Glycerol phosphate shuttle
6165:monoamine neurotransmitter
4484:Cholesterol 7α-hydroxylase
4432:Lanosterol 14α-demethylase
3703:J. Clin. Endocrinol. Metab
3668:J. Clin. Endocrinol. Metab
3633:J. Clin. Endocrinol. Metab
3598:J. Clin. Endocrinol. Metab
3419:J. Clin. Endocrinol. Metab
3116:J. Clin. Endocrinol. Metab
2598:10.33549/physiolres.934516
2495:10.3390/molecules181113228
1488:11β-hydroxyandrostenedione
726:cortisol metabolic process
491:sternocleidomastoid muscle
31:
6854:
6552:
6528:
6225:oxidative phosphorylation
4437:Sterol-C5-desaturase-like
4169:Ecdysone 20-monooxygenase
4120:Stearoyl-CoA desaturase-1
4092:Dopamine beta-hydroxylase
4060:Phenylalanine hydroxylase
3611:10.1210/jcem.84.12.6272-6
3431:10.1210/jcem.77.6.7903314
3128:10.1210/jcem.75.5.1430088
2696:10.1016/j.mce.2003.10.056
2488:(11). MDPI AG: 13228–44.
2337:10.1007/s12020-016-1189-x
1797:"Mouse PubMed Reference:"
1779:"Human PubMed Reference:"
1283:steroid 11β-monooxygenase
1227:
1082:steroid 11β-monooxygenase
1064:
1059:
1055:
1048:
1032:
1019:Chr 8: 142.87 – 142.88 Mb
1013:
998:
973:
962:
947:
922:
911:
898:
894:
879:
875:
866:
853:
849:
834:
830:
821:
808:
804:
789:
785:
776:
761:
754:
750:
734:
711:steroid metabolic process
554:
550:
533:
524:
515:
502:
451:
442:
389:
380:
350:
342:
338:
321:
308:
271:
250:
241:
237:
220:
207:
170:
147:
138:
134:
125:
120:
75:
72:
62:
55:
50:
46:
41:
6416:Isocitrate dehydrogenase
6294:Malate-aspartate shuttle
4339:Phosphomevalonate kinase
3744:Medical Subject Headings
2125:Gupta V (October 2011).
1513:18-hydroxycorticosterone
1426:18-hydroxycorticosterone
1026:Chr 15: 74.72 – 74.73 Mb
696:sterol metabolic process
32:Not to be confused with
27:Protein found in mammals
6463:Glutamate dehydrogenase
6250:Succinate dehydrogenase
3646:10.1210/jcem.85.11.6897
3391:10.1073/pnas.84.20.7193
3170:10.1073/pnas.89.17.8327
2429:WikiJournal of Medicine
2187:Molecular Endocrinology
2140:10.4103/2230-8210.86972
1967:Klinische Wochenschrift
1655:17α-hydroxyprogesterone
1498:11β-hydroxytestosterone
1474:17α-hydroxyprogesterone
1468:11β-hydroxyprogesterone
1301:. Named officially the
1279:Steroid 11β-hydroxylase
625:mitochondrial membranes
594:oxidoreductase activity
467:vastus lateralis muscle
6859:mitochondrial diseases
6458:Aspartate transaminase
6115:fatty acid degradation
4408:Squalene monooxygenase
4154:Squalene monooxygenase
4070:Tryptophan hydroxylase
3819:HIF prolyl-hydroxylase
3716:10.1210/jcem.86.9.7820
3681:10.1210/jcem.86.9.7797
3223:10.1073/pnas.89.4.1458
3062:10.1530/acta.0.1290097
2851:10.1006/abbi.1995.1182
2839:Arch. Biochem. Biophys
2591:(Suppl 2): S187–S192.
2585:Physiological Research
1876:public domain material
1693:
1595:11-Deoxycorticosterone
1546:11-deoxycorticosterone
1449:11-deoxycorticosterone
584:monooxygenase activity
487:triceps brachii muscle
463:lumbar spinal ganglion
409:pancreatic ductal cell
305:15 D3|15 34.29 cM
6572:Mitochondrial carrier
6448:anaplerotic reactions
6284:mitochondrial shuttle
6262:pyrimidine metabolism
4489:Sterol 27-hydroxylase
4370:Geranyl pyrophosphate
3950:Methane monooxygenase
3923:Nitric oxide synthase
3465:10.1093/hmg/6.11.1829
2998:Int J Neonatal Screen
2442:10.15347/WJM/2023.003
2056:10.1210/edrv-15-4-421
1688:
1642:Clinical significance
1390:11β-hydroxylase is a
417:right coronary artery
266:Chromosome 15 (mouse)
6579:Translocator protein
6436:Malate dehydrogenase
6331:Aldosterone synthase
4423:7-Dehydrocholesterol
4065:Tyrosine hydroxylase
3789:steroid hydroxylases
2651:10.1210/jc.2004-0379
2389:10.1210/jc.2015-1023
2199:10.1210/me.2012-1287
1675:Steroidogenic enzyme
1418:aldosterone synthase
1392:steroidogenic enzyme
393:right adrenal cortex
164:Chromosome 8 (human)
6191:Intermembrane space
4413:Lanosterol synthase
4015:iron–sulfur protein
3382:1987PNAS...84.7193C
3214:1992PNAS...89.1458K
3161:1992PNAS...89.8327P
3011:10.3390/ijns9040058
2743:10.1530/EJE-17-0563
1616:Mechanism of action
1287:steroid hydroxylase
651:glucose homeostasis
401:left adrenal cortex
114:CYP11B1 - orthologs
6546:Other/to be sorted
6511:alcohol metabolism
6371:Uncoupling protein
6245:NADH dehydrogenase
4728:Steroid metabolism
4244:Mevalonate pathway
4236:steroid metabolism
3814:Prolyl hydroxylase
2943:Miller WL (2019).
1979:10.1007/bf01711722
1694:
1523:18-hydroxycortisol
856:ENSMUSG00000022589
644:Biological process
613:Cellular component
562:Molecular function
483:thoracic diaphragm
397:left adrenal gland
6866:
6865:
6850:
6849:
6593:Mitochondrial DNA
6587:
6586:
6541:
6540:
6396:citric acid cycle
6379:
6378:
6185:
6184:
6177:Monoamine oxidase
6061:
6060:
4789:
4788:
4785:
4784:
4739:Steroid sulfatase
4716:
4715:
4469:
4468:
4378:
4377:
4334:Mevalonate kinase
4315:HMG-CoA reductase
4182:
4181:
3848:Lysyl hydroxylase
3267:10.1172/JCI115182
2962:10.1159/000501396
2546:978-3-030-32655-5
2290:(in Portuguese).
2096:978-3-642-77765-3
2044:Endocrine Reviews
2021:978-0-7817-5175-9
1828:10.1038/ng0992-66
1717:Steroid numbering
1681:Additional images
1460:medium activity:
1435:strong activity:
1416:, while CYP11B2 (
1276:
1275:
1272:
1271:
1175:metabolic pathway
1075:
1074:
1071:
1070:
1044:
1043:
1009:
1008:
988:
987:
958:
957:
937:
936:
907:
906:
888:
887:
862:
861:
843:
842:
817:
816:
798:
797:
746:
745:
579:metal ion binding
546:
545:
542:
541:
511:
510:
498:
497:
436:
435:
334:
333:
233:
232:
16:(Redirected from
6901:
6730:
6705:
6675:
6655:
6605:
6598:
6550:
6513:
6483:
6451:
6406:Citrate synthase
6399:
6390:
6344:
6314:
6287:
6265:
6228:
6219:
6199:Adenylate kinase
6170:
6146:
6118:
6109:
6088:
6081:
6074:
6065:
4833:(Most belong to
4816:
4809:
4802:
4793:
4747:sulfotransferase
4708:
4664:
4656:
4630:
4592:
4567:
4504:
4390:
4269:(regulated step)
4267:HMG-CoA synthase
4249:
4220:lipid metabolism
4209:
4202:
4195:
4186:
3774:
3767:
3760:
3751:
3728:
3718:
3693:
3683:
3658:
3648:
3623:
3613:
3588:
3578:
3553:
3515:
3477:
3467:
3442:
3413:
3403:
3393:
3360:
3350:
3325:
3288:
3278:
3245:
3235:
3225:
3192:
3182:
3172:
3139:
3110:
3073:
3034:
3033:
3023:
3013:
2989:
2983:
2982:
2964:
2940:
2934:
2933:
2931:
2929:
2923:
2908:
2890:
2881:
2875:
2874:
2872:
2870:
2830:
2824:
2823:
2821:
2819:
2813:
2798:
2780:
2771:
2765:
2764:
2754:
2722:
2716:
2715:
2679:
2673:
2672:
2662:
2630:
2621:
2620:
2610:
2600:
2576:
2570:
2569:
2524:
2518:
2517:
2507:
2497:
2473:
2467:
2460:
2454:
2444:
2426:
2417:
2411:
2410:
2400:
2368:
2357:
2356:
2320:
2314:
2313:
2303:
2279:
2273:
2272:
2236:
2221:
2220:
2210:
2178:
2163:
2162:
2152:
2142:
2122:
2109:
2108:
2074:
2068:
2067:
2039:
2033:
2032:
2030:
2028:
2005:
1999:
1998:
1962:
1956:
1955:
1924:The FEBS Journal
1919:
1913:
1907:
1906:
1902:
1896:
1894:
1873:
1872:
1867:
1858:
1857:
1839:
1811:
1805:
1804:
1793:
1787:
1786:
1775:
1769:
1759:
1748:
1738:
1714:
1702:
1659:21-deoxycortisol
1605:
1591:
1575:
1565:11-Deoxycortisol
1561:
1538:11-deoxycortisol
1478:21-deoxycortisol
1439:11-deoxycortisol
1405:Humans have two
1295:zona fasciculata
1291:zona glomerulosa
1281:, also known as
1229:
1079:
1057:
1056:
1028:
1021:
1004:
992:
983:
967:
963:RefSeq (protein)
953:
941:
932:
916:
892:
873:
847:
828:
802:
783:
752:
656:lipid metabolism
569:iron ion binding
552:
538:
529:
522:
507:
447:
445:Top expressed in
440:
385:
383:Top expressed in
378:
357:
340:
330:
317:
306:
291:
284:
278:
267:
255:
239:
229:
216:
205:
190:
183:
177:
166:
152:
136:
130:
116:
67:
60:
39:
21:
6909:
6908:
6904:
6903:
6902:
6900:
6899:
6898:
6869:
6868:
6867:
6862:
6846:
6726:
6721:
6701:
6696:
6671:
6666:
6651:
6646:
6601:
6583:
6537:
6524:
6509:
6504:
6477:
6472:
6445:
6440:
6393:
6375:
6340:
6335:
6311:steroidogenesis
6308:
6303:
6281:
6276:
6259:
6254:
6222:
6208:
6204:Creatine kinase
6181:
6167:
6162:
6157:
6139:
6134:
6112:
6098:
6092:
6062:
6057:
6025:
6000:
5962:Halloween genes
5929:
5699:
5477:
5396:
5254:
5071:
5000:
4960:
4869:
4838:
4831:cytochrome P450
4820:
4790:
4781:
4721:Other/ungrouped
4712:
4685:
4643:17α-Hydroxylase
4618:
4614:11β-Hydroxylase
4559:17α-Hydroxylase
4528:corticosteroids
4521:
4499:Steroidogenesis
4493:
4465:
4446:
4417:
4374:
4353:
4319:
4300:
4272:
4238:
4213:
4183:
4178:
4132:- miscellaneous
4124:
4096:
4074:
4037:
4005:
3969:
3960:14α-demethylase
3869:
3796:
3781:Oxidoreductases
3778:
3736:
3731:
3696:
3661:
3626:
3591:
3563:Eur. J. Biochem
3556:
3518:
3480:
3458:(11): 1829–34.
3452:Hum. Mol. Genet
3445:
3416:
3363:
3341:(35): 20961–7.
3328:
3291:
3255:J. Clin. Invest
3248:
3195:
3155:(17): 8327–31.
3142:
3113:
3085:(12): 1087–90.
3076:
3050:Acta Endocrinol
3047:
3043:
3041:Further reading
3038:
3037:
2991:
2990:
2986:
2942:
2941:
2937:
2927:
2925:
2921:
2899:(33): 20602–8.
2888:
2883:
2882:
2878:
2868:
2866:
2832:
2831:
2827:
2817:
2815:
2811:
2778:
2773:
2772:
2768:
2724:
2723:
2719:
2690:(1–2): 167–74.
2681:
2680:
2676:
2632:
2631:
2624:
2578:
2577:
2573:
2547:
2529:Prostate Cancer
2526:
2525:
2521:
2475:
2474:
2470:
2424:
2419:
2418:
2414:
2370:
2369:
2360:
2322:
2321:
2317:
2281:
2280:
2276:
2238:
2237:
2224:
2180:
2179:
2166:
2124:
2123:
2112:
2097:
2079:Cytochrome P450
2076:
2075:
2071:
2041:
2040:
2036:
2026:
2024:
2022:
2007:
2006:
2002:
1964:
1963:
1959:
1921:
1920:
1916:
1904:
1892:
1890:
1879:
1870:
1868:
1861:
1816:Nature Genetics
1813:
1812:
1808:
1795:
1794:
1790:
1777:
1776:
1772:
1760:
1751:
1739:
1730:
1725:
1718:
1715:
1706:
1703:
1690:Steroidogenesis
1683:
1671:
1644:
1632:
1618:
1611:
1606:
1597:
1592:
1581:
1576:
1567:
1562:
1534:
1505:weak activity:
1484:androstenedione
1388:
1343:superfamily of
1341:cytochrome P450
1333:
1325:hydroxyl groups
1321:corticosteroids
1066:View/Edit Mouse
1061:View/Edit Human
1024:
1017:
1014:Location (UCSC)
1000:
979:
975:
949:
928:
924:
837:ENSG00000160882
730:
691:immune response
639:
608:
534:
503:
494:
489:
485:
481:
477:
473:
469:
465:
461:
457:
443:
432:
427:
423:
419:
415:
411:
407:
403:
399:
395:
381:
325:
312:
304:
294:
293:
292:
285:
265:
242:Gene location (
224:
211:
203:
193:
192:
191:
184:
162:
139:Gene location (
126:
76:
63:
56:
37:
28:
23:
22:
15:
12:
11:
5:
6907:
6905:
6897:
6896:
6891:
6886:
6881:
6871:
6870:
6864:
6863:
6855:
6852:
6851:
6848:
6847:
6845:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6809:
6804:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6733:
6731:
6723:
6722:
6720:
6719:
6714:
6708:
6706:
6698:
6697:
6695:
6694:
6689:
6684:
6678:
6676:
6668:
6667:
6665:
6664:
6658:
6656:
6648:
6647:
6645:
6644:
6639:
6634:
6629:
6624:
6619:
6614:
6608:
6606:
6595:
6589:
6588:
6585:
6584:
6582:
6581:
6576:
6575:
6574:
6569:
6559:
6553:
6547:
6543:
6542:
6539:
6538:
6536:
6535:
6529:
6526:
6525:
6523:
6522:
6516:
6514:
6506:
6505:
6503:
6502:
6497:
6492:
6486:
6484:
6474:
6473:
6471:
6470:
6465:
6460:
6454:
6452:
6442:
6441:
6439:
6438:
6433:
6428:
6423:
6418:
6413:
6408:
6402:
6400:
6387:
6381:
6380:
6377:
6376:
6374:
6373:
6368:
6363:
6358:
6353:
6347:
6345:
6337:
6336:
6334:
6333:
6328:
6323:
6317:
6315:
6305:
6304:
6302:
6301:
6296:
6290:
6288:
6278:
6277:
6275:
6274:
6268:
6266:
6256:
6255:
6253:
6252:
6247:
6242:
6237:
6231:
6229:
6216:
6214:Inner membrane
6210:
6209:
6207:
6206:
6201:
6195:
6193:
6187:
6186:
6183:
6182:
6180:
6179:
6173:
6171:
6159:
6158:
6156:
6155:
6149:
6147:
6136:
6135:
6133:
6132:
6127:
6121:
6119:
6106:
6104:Outer membrane
6100:
6099:
6093:
6091:
6090:
6083:
6076:
6068:
6059:
6058:
6056:
6055:
6048:
6041:
6033:
6031:
6027:
6026:
6024:
6023:
6016:
6008:
6006:
6002:
6001:
5999:
5998:
5991:
5959:
5958:
5957:
5945:
5937:
5935:
5931:
5930:
5928:
5927:
5920:
5913:
5906:
5899:
5892:
5891:
5890:
5883:
5871:
5864:
5857:
5850:
5849:
5848:
5845:
5835:
5828:
5821:
5814:
5807:
5800:
5793:
5786:
5785:
5784:
5779:
5767:
5766:
5765:
5760:
5748:
5741:
5740:
5739:
5734:
5722:
5715:
5707:
5705:
5701:
5700:
5698:
5697:
5690:
5683:
5676:
5669:
5662:
5640:
5622:
5580:
5564:
5550:
5538:
5531:
5524:
5485:
5483:
5479:
5478:
5476:
5475:
5468:
5467:
5466:
5456:
5455:
5454:
5442:
5441:
5440:
5428:
5421:
5404:
5402:
5398:
5397:
5395:
5394:
5384:
5374:
5364:
5357:
5347:
5327:
5307:
5300:
5290:
5283:
5273:
5262:
5260:
5256:
5255:
5253:
5252:
5242:
5232:
5225:
5215:
5208:
5201:
5194:
5187:
5180:
5148:
5141:
5134:
5120:
5106:
5090:
5079:
5077:
5073:
5072:
5070:
5069:
5064:
5059:
5054:
5049:
5044:
5039:
5034:
5029:
5024:
5019:
5014:
5008:
5006:
5002:
5001:
4999:
4998:
4993:
4988:
4983:
4978:
4972:
4970:
4962:
4961:
4959:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4888:
4883:
4877:
4875:
4871:
4870:
4868:
4867:
4862:
4857:
4852:
4846:
4844:
4840:
4839:
4821:
4819:
4818:
4811:
4804:
4796:
4787:
4786:
4783:
4782:
4780:
4779:
4774:
4769:
4763:
4762:
4761:
4760:
4755:
4743:
4742:
4741:
4724:
4722:
4718:
4717:
4714:
4713:
4711:
4710:
4702:
4696:
4694:
4687:
4686:
4684:
4683:
4682:
4681:
4676:
4666:
4658:
4650:
4645:
4639:
4637:
4627:
4620:
4619:
4617:
4616:
4611:
4609:21-Hydroxylase
4606:
4605:
4604:
4599:
4582:
4581:
4580:
4579:
4574:
4561:
4545:
4544:
4542:18-Hydroxylase
4532:
4530:
4523:
4522:
4520:
4519:
4513:
4511:
4501:
4495:
4494:
4492:
4491:
4486:
4480:
4478:
4471:
4470:
4467:
4466:
4464:
4463:
4457:
4455:
4448:
4447:
4445:
4444:
4439:
4434:
4428:
4426:
4419:
4418:
4416:
4415:
4410:
4405:
4399:
4397:
4387:
4380:
4379:
4376:
4375:
4373:
4372:
4367:
4361:
4359:
4355:
4354:
4352:
4351:
4346:
4341:
4336:
4330:
4328:
4321:
4320:
4318:
4317:
4311:
4309:
4307:Mevalonic acid
4302:
4301:
4299:
4298:
4293:
4288:
4282:
4280:
4274:
4273:
4271:
4270:
4264:
4258:
4256:
4246:
4240:
4239:
4214:
4212:
4211:
4204:
4197:
4189:
4180:
4179:
4177:
4176:
4171:
4166:
4161:
4156:
4151:
4144:Heme oxygenase
4141:
4139:Cyclooxygenase
4135:
4133:
4126:
4125:
4123:
4122:
4117:
4111:
4109:
4098:
4097:
4095:
4094:
4088:
4086:
4076:
4075:
4073:
4072:
4067:
4062:
4056:
4054:
4039:
4038:
4036:
4035:
4030:
4025:
4019:
4017:
4007:
4006:
4004:
4003:
3998:
3993:
3987:
3985:
3971:
3970:
3968:
3967:
3962:
3957:
3952:
3947:
3942:
3941:
3940:
3935:
3930:
3920:
3919:
3918:
3913:
3908:
3903:
3898:
3887:
3885:
3871:
3870:
3868:
3867:
3866:
3865:
3860:
3850:
3845:
3844:
3843:
3838:
3837:
3836:
3831:
3826:
3810:
3808:
3806:2-oxoglutarate
3798:
3797:
3779:
3777:
3776:
3769:
3762:
3754:
3748:
3747:
3735:
3734:External links
3732:
3730:
3729:
3709:(9): 4445–52.
3694:
3659:
3639:(11): 4060–8.
3624:
3589:
3554:
3516:
3478:
3443:
3425:(6): 1677–82.
3414:
3376:(20): 7193–7.
3361:
3326:
3289:
3246:
3208:(4): 1458–62.
3193:
3140:
3122:(5): 1278–81.
3111:
3074:
3044:
3042:
3039:
3036:
3035:
2984:
2955:(6): 416–420.
2935:
2876:
2825:
2789:(9): 4329–35.
2766:
2717:
2674:
2645:(9): 4628–33.
2622:
2571:
2545:
2519:
2468:
2412:
2383:(6): 2283–90.
2358:
2315:
2274:
2222:
2164:
2110:
2095:
2069:
2034:
2020:
2000:
1973:(21): 1011–3.
1957:
1930:(4): 799–810.
1914:
1859:
1806:
1788:
1770:
1749:
1727:
1726:
1724:
1721:
1720:
1719:
1716:
1709:
1707:
1704:
1697:
1682:
1679:
1678:
1677:
1670:
1667:
1661:, in cases of
1643:
1640:
1631:
1628:
1617:
1614:
1613:
1612:
1609:Corticosterone
1607:
1600:
1598:
1593:
1586:
1583:
1582:
1577:
1570:
1568:
1563:
1556:
1550:corticosterone
1533:
1530:
1529:
1528:
1527:
1526:
1516:
1509:corticosterone
1503:
1502:
1501:
1491:
1481:
1471:
1458:
1457:
1456:
1453:corticosterone
1446:
1422:angiotensin II
1387:
1384:
1349:monooxygenases
1332:
1329:
1299:adrenal cortex
1274:
1273:
1270:
1269:
1264:
1258:
1257:
1252:
1246:
1245:
1240:
1234:
1233:
1225:
1224:
1215:
1209:
1208:
1197:
1190:
1189:
1184:
1178:
1177:
1172:
1166:
1165:
1160:
1154:
1153:
1148:
1142:
1141:
1136:
1130:
1129:
1124:
1118:
1117:
1113:
1112:
1107:
1101:
1100:
1095:
1089:
1088:
1084:
1083:
1073:
1072:
1069:
1068:
1063:
1053:
1052:
1046:
1045:
1042:
1041:
1039:
1037:
1030:
1029:
1022:
1015:
1011:
1010:
1007:
1006:
996:
995:
989:
986:
985:
971:
970:
964:
960:
959:
956:
955:
945:
944:
938:
935:
934:
920:
919:
913:
909:
908:
905:
904:
896:
895:
889:
886:
885:
877:
876:
870:
864:
863:
860:
859:
851:
850:
844:
841:
840:
832:
831:
825:
819:
818:
815:
814:
806:
805:
799:
796:
795:
787:
786:
780:
774:
773:
768:
763:
759:
758:
748:
747:
744:
743:
732:
731:
729:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
647:
645:
641:
640:
638:
637:
632:
627:
622:
616:
614:
610:
609:
607:
606:
601:
596:
591:
586:
581:
576:
571:
565:
563:
559:
558:
548:
547:
544:
543:
540:
539:
531:
530:
519:
513:
512:
509:
508:
500:
499:
496:
495:
493:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
449:
448:
437:
434:
433:
431:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
387:
386:
374:
373:
365:
354:
348:
347:
344:RNA expression
336:
335:
332:
331:
323:
319:
318:
310:
307:
302:
296:
295:
286:
279:
273:
269:
268:
263:
257:
256:
248:
247:
235:
234:
231:
230:
222:
218:
217:
209:
206:
201:
195:
194:
185:
178:
172:
168:
167:
160:
154:
153:
145:
144:
132:
131:
124:
118:
117:
74:
70:
69:
61:
53:
52:
48:
47:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6906:
6895:
6892:
6890:
6887:
6885:
6882:
6880:
6877:
6876:
6874:
6861:
6860:
6853:
6843:
6840:
6838:
6835:
6833:
6830:
6828:
6825:
6823:
6820:
6818:
6815:
6813:
6810:
6808:
6805:
6803:
6800:
6798:
6795:
6793:
6790:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6734:
6732:
6729:
6724:
6718:
6715:
6713:
6710:
6709:
6707:
6704:
6699:
6693:
6690:
6688:
6685:
6683:
6680:
6679:
6677:
6674:
6669:
6663:
6660:
6659:
6657:
6654:
6649:
6643:
6640:
6638:
6635:
6633:
6630:
6628:
6625:
6623:
6620:
6618:
6615:
6613:
6610:
6609:
6607:
6604:
6599:
6596:
6594:
6590:
6580:
6577:
6573:
6570:
6568:
6565:
6564:
6563:
6560:
6558:
6555:
6554:
6551:
6548:
6544:
6534:
6531:
6530:
6527:
6521:
6518:
6517:
6515:
6512:
6507:
6501:
6498:
6496:
6493:
6491:
6488:
6487:
6485:
6482:
6481:
6475:
6469:
6466:
6464:
6461:
6459:
6456:
6455:
6453:
6450:
6449:
6443:
6437:
6434:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6403:
6401:
6398:
6397:
6391:
6388:
6386:
6382:
6372:
6369:
6367:
6364:
6362:
6359:
6357:
6354:
6352:
6349:
6348:
6346:
6343:
6338:
6332:
6329:
6327:
6324:
6322:
6319:
6318:
6316:
6313:
6312:
6306:
6300:
6297:
6295:
6292:
6291:
6289:
6286:
6285:
6279:
6273:
6270:
6269:
6267:
6264:
6263:
6257:
6251:
6248:
6246:
6243:
6241:
6238:
6236:
6233:
6232:
6230:
6227:
6226:
6220:
6217:
6215:
6211:
6205:
6202:
6200:
6197:
6196:
6194:
6192:
6188:
6178:
6175:
6174:
6172:
6169:
6166:
6160:
6154:
6151:
6150:
6148:
6145:
6143:
6137:
6131:
6128:
6126:
6123:
6122:
6120:
6117:
6116:
6110:
6107:
6105:
6101:
6096:
6095:Mitochondrial
6089:
6084:
6082:
6077:
6075:
6070:
6069:
6066:
6054:
6053:
6049:
6047:
6046:
6042:
6040:
6039:
6035:
6034:
6032:
6028:
6022:
6021:
6017:
6015:
6014:
6010:
6009:
6007:
6003:
5997:
5996:
5992:
5989:
5985:
5984:
5979:
5975:
5971:
5967:
5963:
5960:
5956:
5953:
5952:
5951:
5950:
5946:
5944:
5943:
5939:
5938:
5936:
5932:
5926:
5925:
5921:
5919:
5918:
5914:
5912:
5911:
5907:
5905:
5904:
5900:
5898:
5897:
5893:
5889:
5888:
5884:
5882:
5881:
5877:
5876:
5875:
5872:
5870:
5869:
5865:
5863:
5862:
5858:
5856:
5855:
5851:
5846:
5843:
5842:
5841:
5840:
5836:
5834:
5833:
5829:
5827:
5826:
5822:
5820:
5819:
5815:
5813:
5812:
5808:
5806:
5805:
5801:
5799:
5798:
5794:
5792:
5791:
5787:
5783:
5780:
5778:
5775:
5774:
5773:
5772:
5768:
5764:
5761:
5759:
5756:
5755:
5754:
5753:
5749:
5747:
5746:
5742:
5738:
5735:
5733:
5730:
5729:
5728:
5727:
5723:
5721:
5720:
5716:
5714:
5713:
5709:
5708:
5706:
5702:
5696:
5695:
5691:
5689:
5688:
5684:
5682:
5681:
5677:
5675:
5674:
5670:
5668:
5667:
5663:
5660:
5656:
5652:
5648:
5644:
5641:
5638:
5634:
5630:
5626:
5623:
5620:
5616:
5612:
5608:
5604:
5600:
5596:
5592:
5588:
5584:
5581:
5578:
5574:
5570:
5569:
5565:
5562:
5558:
5554:
5551:
5548:
5544:
5543:
5539:
5537:
5536:
5532:
5530:
5529:
5525:
5522:
5518:
5514:
5510:
5506:
5502:
5498:
5494:
5490:
5487:
5486:
5484:
5480:
5474:
5473:
5469:
5465:
5462:
5461:
5460:
5457:
5453:
5450:
5449:
5448:
5447:
5443:
5439:
5436:
5435:
5434:
5433:
5429:
5427:
5426:
5422:
5419:
5415:
5411:
5410:
5406:
5405:
5403:
5399:
5392:
5388:
5385:
5382:
5378:
5375:
5372:
5368:
5365:
5363:
5362:
5358:
5355:
5351:
5348:
5345:
5341:
5337:
5333:
5332:
5328:
5325:
5321:
5317:
5313:
5312:
5308:
5306:
5305:
5301:
5298:
5294:
5291:
5289:
5288:
5284:
5281:
5277:
5274:
5271:
5267:
5264:
5263:
5261:
5257:
5250:
5246:
5243:
5240:
5236:
5233:
5231:
5230:
5226:
5223:
5219:
5216:
5214:
5213:
5209:
5207:
5206:
5202:
5200:
5199:
5195:
5193:
5192:
5188:
5186:
5185:
5181:
5178:
5174:
5170:
5166:
5162:
5158:
5154:
5153:
5149:
5147:
5146:
5142:
5140:
5139:
5135:
5132:
5128:
5124:
5121:
5118:
5114:
5110:
5107:
5104:
5100:
5096:
5095:
5091:
5088:
5084:
5081:
5080:
5078:
5074:
5068:
5065:
5063:
5060:
5058:
5055:
5053:
5050:
5048:
5045:
5043:
5040:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5020:
5018:
5015:
5013:
5010:
5009:
5007:
5003:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4973:
4971:
4968:
4963:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4878:
4876:
4872:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4847:
4845:
4841:
4836:
4832:
4828:
4824:
4817:
4812:
4810:
4805:
4803:
4798:
4797:
4794:
4778:
4775:
4773:
4770:
4768:
4765:
4764:
4759:
4756:
4754:
4751:
4750:
4749:
4748:
4744:
4740:
4737:
4736:
4735:
4734:
4729:
4726:
4725:
4723:
4719:
4709:
4703:
4701:
4698:
4697:
4695:
4693:
4688:
4680:
4677:
4675:
4672:
4671:
4670:
4667:
4665:
4659:
4657:
4651:
4649:
4646:
4644:
4641:
4640:
4638:
4636:
4631:
4628:
4626:
4621:
4615:
4612:
4610:
4607:
4603:
4600:
4598:
4595:
4594:
4593:
4587:
4584:
4583:
4578:
4575:
4573:
4570:
4569:
4568:
4562:
4560:
4557:
4555:
4551:
4547:
4546:
4543:
4540:
4538:
4534:
4533:
4531:
4529:
4524:
4518:
4515:
4514:
4512:
4510:
4505:
4502:
4500:
4496:
4490:
4487:
4485:
4482:
4481:
4479:
4477:
4472:
4462:
4459:
4458:
4456:
4453:
4449:
4443:
4440:
4438:
4435:
4433:
4430:
4429:
4427:
4424:
4420:
4414:
4411:
4409:
4406:
4404:
4401:
4400:
4398:
4396:
4391:
4388:
4386:
4381:
4371:
4368:
4366:
4363:
4362:
4360:
4356:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4331:
4329:
4327:
4322:
4316:
4313:
4312:
4310:
4308:
4303:
4297:
4294:
4292:
4289:
4287:
4286:HMG-CoA lyase
4284:
4283:
4281:
4279:
4275:
4268:
4265:
4263:
4260:
4259:
4257:
4255:
4250:
4247:
4245:
4241:
4237:
4233:
4229:
4225:
4221:
4217:
4210:
4205:
4203:
4198:
4196:
4191:
4190:
4187:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4149:
4145:
4142:
4140:
4137:
4136:
4134:
4131:
4127:
4121:
4118:
4116:
4113:
4112:
4110:
4107:
4103:
4099:
4093:
4090:
4089:
4087:
4085:
4081:
4077:
4071:
4068:
4066:
4063:
4061:
4058:
4057:
4055:
4052:
4051:BH4 dependent
4048:
4044:
4040:
4034:
4031:
4029:
4026:
4024:
4021:
4020:
4018:
4016:
4012:
4008:
4002:
3999:
3997:
3994:
3992:
3989:
3988:
3986:
3984:
3980:
3976:
3972:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3939:
3936:
3934:
3931:
3929:
3926:
3925:
3924:
3921:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3893:
3892:
3889:
3888:
3886:
3884:
3880:
3876:
3872:
3864:
3861:
3859:
3856:
3855:
3854:
3851:
3849:
3846:
3842:
3839:
3835:
3832:
3830:
3827:
3825:
3822:
3821:
3820:
3817:
3816:
3815:
3812:
3811:
3809:
3807:
3803:
3799:
3794:
3790:
3786:
3782:
3775:
3770:
3768:
3763:
3761:
3756:
3755:
3752:
3745:
3741:
3738:
3737:
3733:
3726:
3722:
3717:
3712:
3708:
3704:
3700:
3695:
3691:
3687:
3682:
3677:
3674:(9): 4326–9.
3673:
3669:
3665:
3660:
3656:
3652:
3647:
3642:
3638:
3634:
3630:
3625:
3621:
3617:
3612:
3607:
3603:
3599:
3595:
3590:
3586:
3582:
3577:
3572:
3568:
3564:
3560:
3555:
3551:
3547:
3543:
3539:
3535:
3534:10.1038/10297
3531:
3528:(3): 239–47.
3527:
3523:
3517:
3513:
3509:
3505:
3501:
3497:
3496:10.1038/10290
3493:
3489:
3485:
3479:
3475:
3471:
3466:
3461:
3457:
3453:
3449:
3444:
3440:
3436:
3432:
3428:
3424:
3420:
3415:
3411:
3407:
3402:
3397:
3392:
3387:
3383:
3379:
3375:
3371:
3367:
3362:
3358:
3354:
3349:
3344:
3340:
3336:
3335:J. Biol. Chem
3332:
3327:
3323:
3319:
3315:
3311:
3307:
3303:
3299:
3295:
3290:
3286:
3282:
3277:
3272:
3268:
3264:
3261:(5): 1664–7.
3260:
3256:
3252:
3247:
3243:
3239:
3234:
3229:
3224:
3219:
3215:
3211:
3207:
3203:
3199:
3194:
3190:
3186:
3181:
3176:
3171:
3166:
3162:
3158:
3154:
3150:
3146:
3141:
3137:
3133:
3129:
3125:
3121:
3117:
3112:
3108:
3104:
3100:
3096:
3092:
3088:
3084:
3080:
3075:
3071:
3067:
3063:
3059:
3056:(2): 97–108.
3055:
3051:
3046:
3045:
3040:
3031:
3027:
3022:
3017:
3012:
3007:
3003:
2999:
2995:
2988:
2985:
2980:
2976:
2972:
2968:
2963:
2958:
2954:
2950:
2946:
2939:
2936:
2920:
2916:
2912:
2907:
2902:
2898:
2894:
2893:J. Biol. Chem
2887:
2880:
2877:
2864:
2860:
2856:
2852:
2848:
2844:
2840:
2836:
2829:
2826:
2810:
2806:
2802:
2797:
2792:
2788:
2784:
2783:J. Biol. Chem
2777:
2770:
2767:
2762:
2758:
2753:
2748:
2744:
2740:
2736:
2732:
2728:
2721:
2718:
2713:
2709:
2705:
2701:
2697:
2693:
2689:
2685:
2678:
2675:
2670:
2666:
2661:
2656:
2652:
2648:
2644:
2640:
2636:
2629:
2627:
2623:
2618:
2614:
2609:
2604:
2599:
2594:
2590:
2586:
2582:
2575:
2572:
2568:
2564:
2560:
2556:
2552:
2548:
2542:
2538:
2534:
2530:
2523:
2520:
2515:
2511:
2506:
2501:
2496:
2491:
2487:
2483:
2479:
2472:
2469:
2466:
2464:
2459:
2452:
2448:
2443:
2438:
2434:
2430:
2423:
2416:
2413:
2408:
2404:
2399:
2394:
2390:
2386:
2382:
2378:
2374:
2367:
2365:
2363:
2359:
2354:
2350:
2346:
2342:
2338:
2334:
2330:
2326:
2319:
2316:
2311:
2307:
2302:
2297:
2294:(5): 713–23.
2293:
2289:
2285:
2278:
2275:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2235:
2233:
2231:
2229:
2227:
2223:
2218:
2214:
2209:
2204:
2200:
2196:
2193:(2): 315–24.
2192:
2188:
2184:
2177:
2175:
2173:
2171:
2169:
2165:
2160:
2156:
2151:
2146:
2141:
2136:
2132:
2128:
2121:
2119:
2117:
2115:
2111:
2106:
2102:
2098:
2092:
2088:
2084:
2080:
2073:
2070:
2065:
2061:
2057:
2053:
2050:(4): 421–38.
2049:
2045:
2038:
2035:
2023:
2017:
2013:
2012:
2004:
2001:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1961:
1958:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1918:
1915:
1911:
1910:public domain
1901:
1888:
1887:
1882:
1877:
1866:
1864:
1860:
1855:
1851:
1847:
1843:
1838:
1833:
1829:
1825:
1821:
1817:
1810:
1807:
1802:
1798:
1792:
1789:
1784:
1780:
1774:
1771:
1767:
1763:
1758:
1756:
1754:
1750:
1746:
1742:
1737:
1735:
1733:
1729:
1722:
1713:
1708:
1701:
1696:
1691:
1687:
1680:
1676:
1673:
1672:
1668:
1666:
1664:
1660:
1656:
1651:
1649:
1641:
1639:
1637:
1629:
1627:
1624:
1615:
1610:
1604:
1599:
1596:
1590:
1585:
1580:
1574:
1569:
1566:
1560:
1555:
1553:
1551:
1547:
1543:
1539:
1531:
1524:
1520:
1517:
1514:
1510:
1507:
1506:
1504:
1499:
1495:
1492:
1489:
1485:
1482:
1479:
1475:
1472:
1469:
1465:
1462:
1461:
1459:
1454:
1450:
1447:
1444:
1440:
1437:
1436:
1434:
1433:
1432:
1429:
1427:
1423:
1419:
1415:
1410:
1408:
1403:
1401:
1397:
1393:
1385:
1383:
1381:
1377:
1373:
1368:
1366:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1330:
1328:
1326:
1322:
1319:
1315:
1312:
1308:
1304:
1300:
1296:
1292:
1289:found in the
1288:
1284:
1280:
1268:
1265:
1263:
1259:
1256:
1253:
1251:
1247:
1244:
1241:
1239:
1235:
1230:
1226:
1223:
1219:
1216:
1214:
1213:Gene Ontology
1210:
1207:
1204:
1201:
1198:
1195:
1191:
1188:
1185:
1183:
1179:
1176:
1173:
1171:
1167:
1164:
1161:
1159:
1155:
1152:
1151:NiceZyme view
1149:
1147:
1143:
1140:
1137:
1135:
1131:
1128:
1125:
1123:
1119:
1114:
1111:
1108:
1106:
1102:
1099:
1096:
1094:
1090:
1085:
1080:
1077:
1067:
1062:
1058:
1054:
1051:
1047:
1040:
1038:
1035:
1031:
1027:
1023:
1020:
1016:
1012:
1005:
1003:
997:
993:
990:
984:
982:
978:
972:
968:
965:
961:
954:
952:
946:
942:
939:
933:
931:
927:
921:
917:
914:
912:RefSeq (mRNA)
910:
903:
902:
897:
893:
890:
884:
883:
878:
874:
871:
869:
865:
858:
857:
852:
848:
845:
839:
838:
833:
829:
826:
824:
820:
813:
812:
807:
803:
800:
794:
793:
788:
784:
781:
779:
775:
772:
769:
767:
764:
760:
757:
753:
749:
742:
738:
733:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
636:
633:
631:
630:mitochondrion
628:
626:
623:
621:
618:
617:
615:
612:
611:
605:
602:
600:
597:
595:
592:
590:
587:
585:
582:
580:
577:
575:
572:
570:
567:
566:
564:
561:
560:
557:
556:Gene ontology
553:
549:
537:
532:
528:
523:
520:
518:
514:
506:
501:
490:
486:
482:
478:
474:
470:
466:
462:
458:
455:adrenal gland
454:
453:
450:
446:
441:
438:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
391:
388:
384:
379:
376:
375:
372:
370:
366:
364:
363:
359:
358:
355:
353:
349:
345:
341:
337:
329:
324:
320:
316:
311:
301:
297:
290:
283:
277:
270:
262:
258:
254:
249:
245:
240:
236:
228:
223:
219:
215:
210:
200:
196:
189:
182:
176:
169:
165:
159:
155:
151:
146:
142:
137:
133:
129:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
79:
71:
66:
59:
54:
49:
45:
40:
35:
30:
19:
6856:
6703:ATP synthase
6510:
6478:
6446:
6394:
6361:ATP synthase
6341:
6309:
6282:
6260:
6240:Cytochrome c
6223:
6163:
6153:Kynureninase
6140:
6113:
6050:
6043:
6036:
6018:
6011:
5993:
5987:
5981:
5977:
5973:
5969:
5965:
5947:
5940:
5922:
5915:
5908:
5901:
5894:
5885:
5878:
5873:
5866:
5859:
5852:
5837:
5830:
5823:
5816:
5809:
5802:
5795:
5788:
5769:
5750:
5743:
5724:
5717:
5710:
5692:
5685:
5678:
5671:
5664:
5642:
5624:
5582:
5566:
5552:
5540:
5533:
5526:
5488:
5470:
5458:
5444:
5430:
5423:
5407:
5386:
5376:
5366:
5359:
5349:
5329:
5309:
5302:
5292:
5285:
5275:
5265:
5244:
5234:
5227:
5217:
5210:
5203:
5196:
5189:
5182:
5150:
5143:
5136:
5122:
5108:
5092:
5082:
4745:
4731:
4669:5α-Reductase
4625:sex hormones
4585:
4548:
4535:
4509:pregnenolone
3983:flavoprotein
3787:, including
3785:dioxygenases
3706:
3702:
3671:
3667:
3636:
3632:
3604:(12): 4749.
3601:
3597:
3569:(3): 720–6.
3566:
3562:
3525:
3521:
3490:(3): 231–8.
3487:
3483:
3455:
3451:
3422:
3418:
3373:
3369:
3338:
3334:
3300:(2): 345–9.
3297:
3293:
3258:
3254:
3205:
3201:
3152:
3148:
3119:
3115:
3082:
3078:
3053:
3049:
3001:
2997:
2987:
2952:
2948:
2938:
2926:. Retrieved
2896:
2892:
2879:
2867:. Retrieved
2845:(2): 412–6.
2842:
2838:
2828:
2816:. Retrieved
2786:
2782:
2769:
2737:(1): R1–R9.
2734:
2730:
2720:
2687:
2683:
2677:
2642:
2638:
2588:
2584:
2574:
2566:
2528:
2522:
2485:
2481:
2471:
2455:
2432:
2428:
2415:
2380:
2376:
2331:(1): 19–36.
2328:
2324:
2318:
2291:
2287:
2277:
2244:
2240:
2190:
2186:
2130:
2078:
2072:
2047:
2043:
2037:
2025:. Retrieved
2010:
2003:
1970:
1966:
1960:
1927:
1923:
1917:
1898:
1891:. Retrieved
1884:
1837:11577/133580
1822:(1): 66–74.
1819:
1815:
1809:
1800:
1791:
1782:
1773:
1652:
1645:
1633:
1619:
1535:
1494:testosterone
1464:progesterone
1430:
1411:
1404:
1389:
1371:
1369:
1336:
1334:
1310:
1302:
1282:
1278:
1277:
1139:BRENDA entry
1076:
999:
981:NP_001021384
974:
948:
930:NM_001026213
923:
899:
880:
854:
835:
809:
790:
770:
765:
604:heme binding
475:carotid body
413:right testis
367:
360:
225:142,879,846
212:142,872,356
73:External IDs
29:
6653:Complex III
4823:Cytochromes
4648:17,20-Lyase
4537:aldosterone
4452:Desmosterol
4385:cholesterol
4296:Thiophorase
4278:Ketogenesis
4228:cholesterol
2247:: 203–212.
1893:30 November
1353:cholesterol
1127:IntEnz view
1087:Identifiers
425:metanephros
421:left testis
326:74,728,167
313:74,722,859
51:Identifiers
6889:Metabolism
6873:Categories
6673:Complex IV
6480:urea cycle
6168:metabolism
6144:metabolism
6142:tryptophan
6030:CYP701-999
6005:CYP501-699
5934:CYP301-499
5704:CYP101-281
4827:oxygenases
4476:Bile acids
4395:lanosterol
4230:synthesis
4216:Metabolism
4115:Tyrosinase
4082:: reduced
4045:: reduced
4013:: reduced
3977:: reduced
3522:Nat. Genet
3484:Nat. Genet
1768:, May 2017
1747:, May 2017
1723:References
1630:Regulation
1396:metabolism
1380:metyrapone
1359:and other
1305:, it is a
1196:structures
1163:KEGG entry
1110:9029-66-7
429:ectocervix
371:(ortholog)
94:HomoloGene
6857:see also
6603:Complex I
6411:Aconitase
6038:CYP704B22
4733:sulfatase
4700:Aromatase
4692:estrogens
4635:androgens
4554:cortisone
4084:ascorbate
4047:pteridine
3512:195213008
3294:FEBS Lett
3004:(4): 58.
2979:201733086
2563:209748543
2482:Molecules
2463:CC BY 4.0
2451:257943362
2325:Endocrine
1376:etomidate
1116:Databases
1098:1.14.15.4
1002:NP_034121
977:NP_000488
951:NM_009991
926:NM_000497
756:Orthologs
471:spermatid
128:1.14.15.4
122:EC number
102:GeneCards
6557:Frataxin
6431:Fumarase
6097:proteins
6052:CYP720A1
6020:CYP504B1
5995:CYP318A1
5988:CYP315A1
5983:CYP314A1
5978:CYP307A2
5974:CYP307A1
5970:CYP306A1
5966:CYP302A1
5942:CYP303A1
5917:CYP199A2
5896:CYP176A1
5854:CYP154C3
5818:CYP125A1
5804:CYP119A1
5797:CYP113A1
5745:CYP106A2
5719:CYP102A1
5712:CYP101A1
5482:CYP71-99
5401:CYP51-69
5259:CYP21-49
4550:cortisol
4358:Geranyl-
3725:11549691
3690:11549669
3655:11095433
3620:10599751
3585:10411633
3542:10391210
3504:10391209
3322:35151332
3107:23091842
3099:11903322
3030:37873849
3021:10594498
2971:31450227
2919:Archived
2863:Archived
2809:Archived
2761:28904009
2704:15062555
2669:15356073
2617:33094617
2555:31900912
2514:24165582
2465:license.
2407:25850025
2353:11153844
2345:27928728
2310:15761543
2261:29277707
2217:23322723
2159:22145132
2105:81304246
2027:30 April
1995:20077711
1952:45997341
1944:18215163
1764:–
1743:–
1669:See also
1621:that of
1579:Cortisol
1542:cortisol
1519:cortisol
1443:cortisol
1407:isozymes
1400:steroids
1386:Function
1357:steroids
1267:proteins
1255:articles
1243:articles
1200:RCSB PDB
1050:Wikidata
735:Sources:
620:membrane
479:gastrula
405:testicle
6884:Enzymes
6717:MT-ATP8
6712:MT-ATP6
6632:MT-ND4L
5924:CYP255A
5903:CYP183A
5868:CYP161C
5861:CYP158A
5694:CYP99A3
5687:CYP97C1
5680:CYP93E1
5673:CYP90C1
5666:CYP88D6
5535:CYP73A1
5528:CYP72A1
5076:CYP5-20
4758:SULT2A1
4753:SULT1A1
4254:HMG-CoA
4232:enzymes
4224:ketones
4130:1.14.99
4108:: other
4102:1.14.18
4080:1.14.17
4043:1.14.16
4011:1.14.15
3975:1.14.14
3875:1.14.13
3802:1.14.11
3550:4636523
3474:9302260
3439:7903314
3410:3499608
3378:Bibcode
3357:2592361
3314:2401360
3285:2022736
3242:1741400
3210:Bibcode
3189:1518866
3157:Bibcode
3136:1430088
3070:8372604
2928:21 July
2915:2173715
2869:26 June
2859:7893157
2818:21 July
2805:6783659
2752:5705277
2660:1283128
2608:8603739
2505:6270415
2398:4454804
2269:3700135
2208:5417327
2150:3230101
2064:7988480
1987:6096625
1846:1303253
1766:Ensembl
1745:Ensembl
1623:P450scc
1372:CYP11B1
1345:enzymes
1337:CYP11B1
1318:adrenal
1311:CYP11B1
1307:protein
1297:of the
1285:, is a
1222:QuickGO
1187:profile
1170:MetaCyc
1105:CAS no.
868:UniProt
823:Ensembl
762:Species
741:QuickGO
346:pattern
106:CYP11B1
65:CYP11B1
58:Aliases
42:CYP11B1
6822:MT-TS2
6817:MT-TS1
6787:MT-TL2
6782:MT-TL1
6692:MT-CO3
6687:MT-CO2
6682:MT-CO1
6662:MT-CYB
6642:MT-ND6
6637:MT-ND5
6627:MT-ND4
6622:MT-ND3
6617:MT-ND2
6612:MT-ND1
6385:Matrix
6045:CYP710
6013:CYP503
5949:CYP305
5910:CYP197
5874:CYP170
5839:CYP152
5832:CYP147
5825:CYP139
5811:CYP123
5790:CYP111
5771:CYP109
5752:CYP107
5726:CYP105
4965:CYP3 (
3979:flavin
3858:ALKBH1
3746:(MeSH)
3723:
3688:
3653:
3618:
3583:
3548:
3540:
3510:
3502:
3472:
3437:
3408:
3401:299256
3398:
3355:
3320:
3312:
3283:
3276:295260
3273:
3240:
3230:
3187:
3177:
3134:
3105:
3097:
3068:
3028:
3018:
2977:
2969:
2913:
2857:
2803:
2759:
2749:
2712:617448
2710:
2702:
2667:
2657:
2615:
2605:
2561:
2553:
2543:
2512:
2502:
2449:
2435:: 29.
2405:
2395:
2351:
2343:
2308:
2267:
2259:
2215:
2205:
2157:
2147:
2103:
2093:
2062:
2018:
1993:
1985:
1950:
1942:
1854:975796
1852:
1844:
1361:lipids
1250:PubMed
1232:Search
1218:AmiGO
1206:PDBsum
1146:ExPASy
1134:BRENDA
1122:IntEnz
1093:EC no.
1036:search
1034:PubMed
901:P15539
882:P15538
778:Entrez
517:BioGPS
204:8q24.3
98:128035
82:610613
6842:MT-TY
6837:MT-TW
6832:MT-TV
6827:MT-TT
6812:MT-TR
6807:MT-TQ
6802:MT-TP
6797:MT-TN
6792:MT-TM
6777:MT-TK
6772:MT-TI
6767:MT-TH
6762:MT-TG
6757:MT-TF
6752:MT-TE
6747:MT-TD
6742:MT-TC
6737:MT-TA
6533:PMPCB
6520:ALDH2
6342:other
5643:CYP81
5625:CYP80
5583:CYP79
5568:CYP76
5553:CYP75
5542:CYP74
5489:CYP71
5472:CYP61
5459:CYP56
5446:CYP55
5432:CYP53
5425:CYP52
5409:CYP51
5387:CYP46
5377:CYP39
5367:CYP35
5361:CYP29
5350:CYP28
5331:CYP27
5311:CYP26
5304:CYP25
5293:CYP24
5287:CYP23
5276:CYP22
5266:CYP21
5245:CYP20
5235:CYP19
5229:CYP18
5218:CYP17
5212:CYP16
5205:CYP15
5198:CYP14
5191:CYP13
5184:CYP12
5152:CYP11
5145:CYP10
4967:CYP3A
4837:1.14)
4586:both:
4326:DMAPP
4148:HMOX1
3883:NADPH
3841:P4HTM
3834:EGLN3
3829:EGLN2
3824:EGLN1
3795:1.14)
3546:S2CID
3508:S2CID
3318:S2CID
3233:48470
3180:49911
3103:S2CID
2975:S2CID
2922:(PDF)
2889:(PDF)
2812:(PDF)
2779:(PDF)
2708:S2CID
2559:S2CID
2447:S2CID
2425:(PDF)
2349:S2CID
2265:S2CID
2101:S2CID
1991:S2CID
1948:S2CID
1878:from
1850:S2CID
1182:PRIAM
811:13072
771:Mouse
766:Human
737:Amigo
369:Mouse
362:Human
309:Start
244:Mouse
208:Start
141:Human
90:88584
6728:tRNA
5138:CYP9
5123:CYP8
5109:CYP7
5094:CYP6
5083:CYP5
5005:CYP4
4874:CYP2
4843:CYP1
4705:17β-
4661:17β-
4564:11β-
4454:path
4425:path
4164:21A2
4159:17A1
4033:11A1
4028:11B2
4023:11B1
3991:19A1
3938:NOS3
3933:NOS2
3928:NOS1
3916:FMO5
3911:FMO4
3906:FMO3
3901:FMO2
3896:FMO1
3879:NADH
3853:AlkB
3721:PMID
3686:PMID
3651:PMID
3616:PMID
3581:PMID
3538:PMID
3500:PMID
3470:PMID
3435:PMID
3406:PMID
3353:PMID
3310:PMID
3281:PMID
3238:PMID
3185:PMID
3132:PMID
3095:PMID
3066:PMID
3026:PMID
2967:PMID
2930:2012
2911:PMID
2871:2019
2855:PMID
2820:2012
2801:PMID
2757:PMID
2700:PMID
2665:PMID
2613:PMID
2551:PMID
2541:ISBN
2510:PMID
2403:PMID
2341:PMID
2306:PMID
2257:PMID
2213:PMID
2155:PMID
2091:ISBN
2060:PMID
2029:2012
2016:ISBN
1983:PMID
1940:PMID
1895:2020
1842:PMID
1636:ACTH
1544:and
1414:ACTH
1378:and
1370:The
1365:gene
1335:The
1331:Gene
1314:gene
1293:and
1262:NCBI
1203:PDBe
1158:KEGG
792:1584
352:Bgee
300:Band
261:Chr.
199:Band
158:Chr.
78:OMIM
5521:BA1
5517:AV1
5513:AJ4
5052:F22
5047:F12
5042:F11
5017:A22
5012:A11
4996:A43
4991:A37
4916:C19
4911:C18
4891:A13
4707:HSD
4690:To
4663:HSD
4655:HSD
4653:3β-
4633:To
4623:To
4591:HSD
4589:3β-
4566:HSD
4526:To
4507:To
4474:To
4393:To
4383:To
4324:To
4305:To
4252:To
4001:2E1
3996:2D6
3981:or
3955:3A4
3881:or
3863:FTO
3711:doi
3676:doi
3641:doi
3606:doi
3571:doi
3567:262
3530:doi
3492:doi
3460:doi
3427:doi
3396:PMC
3386:doi
3343:doi
3339:264
3302:doi
3298:269
3271:PMC
3263:doi
3228:PMC
3218:doi
3175:PMC
3165:doi
3124:doi
3087:doi
3058:doi
3054:129
3016:PMC
3006:doi
2957:doi
2901:doi
2897:265
2847:doi
2843:317
2791:doi
2787:256
2747:PMC
2739:doi
2735:178
2692:doi
2688:214
2655:PMC
2647:doi
2603:PMC
2593:doi
2533:doi
2500:PMC
2490:doi
2437:doi
2393:PMC
2385:doi
2381:100
2333:doi
2296:doi
2249:doi
2245:178
2203:PMC
2195:doi
2145:PMC
2135:doi
2083:doi
2052:doi
1975:doi
1932:doi
1928:275
1832:hdl
1824:doi
1657:to
1638:).
1548:to
1540:to
1521:to
1511:to
1496:to
1486:to
1476:to
1466:to
1451:to
1441:to
1398:of
1238:PMC
1194:PDB
322:End
221:End
110:OMA
86:MGI
6875::
5986:,
5980:,
5976:,
5972:,
5968:,
5964:(
5955:M2
5887:B1
5880:A1
5847:B1
5844:A1
5782:E1
5777:B1
5763:G1
5758:A1
5737:D7
5732:A1
5659:E9
5657:,
5655:E7
5653:,
5651:E3
5649:,
5647:E1
5637:G2
5635:,
5633:B1
5631:,
5629:A1
5619:D4
5617:,
5615:D3
5613:,
5611:D2
5609:,
5607:D1
5605:,
5603:B3
5601:,
5599:B2
5597:,
5595:B1
5593:,
5591:A2
5589:,
5587:A1
5577:M7
5575:,
5573:B6
5561:B1
5559:,
5557:A1
5547:D1
5519:,
5515:,
5511:,
5509:Z6
5507:,
5505:C4
5503:,
5501:C3
5499:,
5497:C2
5495:,
5493:C1
5464:A1
5452:A1
5438:A1
5418:F1
5416:,
5414:A1
5391:A1
5381:A1
5371:B1
5354:A1
5344:C1
5342:,
5340:B1
5338:,
5336:A1
5324:C1
5322:,
5320:B1
5318:,
5316:A1
5297:A1
5280:A1
5270:A2
5249:A1
5239:A1
5222:A1
5177:C1
5175:,
5173:B3
5171:,
5169:B2
5167:,
5165:B1
5163:,
5161:A2
5159:,
5157:A1
5131:B1
5129:,
5127:A1
5117:B1
5115:,
5113:A1
5103:M2
5101:,
5099:G1
5087:A1
5067:Z1
5062:X1
5057:V2
5037:F8
5032:F3
5027:F2
5022:B1
4986:A7
4981:A5
4976:A4
4956:W1
4951:U1
4946:S1
4941:R1
4936:J2
4931:F1
4926:E1
4921:D6
4906:C9
4901:C8
4896:B6
4886:A7
4881:A6
4865:B1
4860:A5
4855:A2
4850:A1
4835:EC
4829::
4825:,
4730::
4222:–
4218::
4106:19
3877::
3804::
3793:EC
3783::
3719:.
3707:86
3705:.
3701:.
3684:.
3672:86
3670:.
3666:.
3649:.
3637:85
3635:.
3631:.
3614:.
3602:84
3600:.
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3579:.
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3526:22
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3506:.
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3120:75
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3052:.
3024:.
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3000:.
2996:.
2973:.
2965:.
2953:91
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2058:.
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2046:.
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1981:.
1971:62
1969:.
1946:.
1938:.
1926:.
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1731:^
1665:.
1650:.
1428:.
1382:.
1367:.
1355:,
1220:/
739:/
328:bp
315:bp
227:bp
214:bp
108:;
104::
100:;
96::
92:;
88::
84:;
80::
6087:e
6080:t
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