179:
204:
1290:
426:
419:
412:
3162:
210:
40:
4637:
1358:. Blood-clotting abnormalities may occur more frequently in males with XLI and female carriers. Knockdown of STS gene expression in human skin cell cultures affects pathways associated with skin function, brain and heart development, and blood-clotting that may be relevant for explaining the skin condition and increased likelihood of ADHD/autism, cardiac arrhythmias and disorders of
2616:
Ballabio A, Parenti G, Carrozzo R, Coppa G, Felici L, Migliori V, et al. (July 1988). "X/Y translocation in a family with X-linked ichthyosis, chondrodysplasia punctata, and mental retardation: DNA analysis reveals deletion of the steroid sulphatase gene and translocation of its Y pseudogene".
66:
2654:
Yen PH, Marsh B, Allen E, Tsai SP, Ellison J, Connolly L, et al. (December 1988). "The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution".
3064:
Matsuoka R, Yanaihara A, Saito H, Furusawa Y, Toma Y, Shimizu Y, et al. (June 2002). "Regulation of estrogen activity in human endometrium: effect of IL-1β on steroid sulfatase activity in human endometrial stromal cells".
2549:
Yen PH, Allen E, Marsh B, Mohandas T, Wang N, Taggart RT, Shapiro LJ (May 1987). "Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange".
4040:
1385:, and others. A number of clinical trials have been performed with inhibitors of the enzyme that have demonstrated clinical benefit, particularly in oncology and so far up to Phase II. The non-steroidal drug
1416:. The most potent inhibitors are based around the aryl sulfamate pharmacophore and it is thought that such compounds irreversibly modify the active site formylglycine residue of steroid sulfatase.
2587:
Conary JT, Lorkowski G, Schmidt B, Pohlmann R, Nagel G, Meyer HE, et al. (April 1987). "Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase".
2914:
Sugawara T, Shimizu H, Hoshi N, Fujimoto Y, Nakajima A, Fujimoto S (March 2000). "PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene".
1365:
Steroid sulfates like DHEA sulfate and estrone sulfate serve as large biologically inert reservoirs for conversion into androgens and estrogens, respectively, and hence are of significance for
4033:
2799:
Migeon BR, Shapiro LJ, Norum RA, Mohandas T, Axelman J, Dabora RL (October 1982). "Differential expression of steroid sulphatase locus on active and inactive human X chromosome".
1225:
4026:
1331:
is caused by a lack of breakdown and thus accumulation of cholesterol sulfate, a steroid that stabilizes cell membranes and adds cohesion, in the outer layers of the skin.
217:
1118:
1137:
2762:
Müller CR, Wahlström J, Ropers HH (1982). "Further evidence for the assignment of the steroid sulfatase X-linked ichthyosis locus to the telomer of Xp".
4410:
4405:
140:
665:
4236:
4182:
3395:
2881:"Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein"
2456:
Shankaran R, Ameen M, Daniel WL, Davidson RG, Chang PL (June 1991). "Characterization of arylsulfatase C isozymes from human liver and placenta".
1718:"Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein"
4600:
4350:
3642:
2520:
Kawano J, Kotani T, Ohtaki S, Minamino N, Matsuo H, Oinuma T, Aikawa E (August 1989). "Characterization of rat and human steroid sulfatases".
3141:
3161:
4657:
4119:
3556:
1537:
4018:
1896:"Cardiac arrhythmia in individuals with steroid sulfatase deficiency (X-linked ichthyosis): candidate anatomical and biochemical pathways"
1334:
Genetic deletions including STS are associated with an increased risk of developmental and mood disorders (and associated traits), and of
2953:"Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes"
2927:
4538:
4494:
4397:
4177:
3657:
3651:
3452:
3202:
4486:
4422:
3500:
3611:
3400:
2288:
2487:"Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells"
914:
1558:
1130:
4294:
4124:
3718:
3606:
2986:
Jimenez Vaca AL, Valdes-Flores M, Rivera-Vega MR, González-Huerta LM, Kofman-Alfaro SH, Cuevas-Covarrubias SA (December 2001).
1524:
4275:
3527:
3437:
3390:
1980:
McGeoghan F, Camera E, Maiellaro M, Menon M, Huang M, Dewan P, Ziaj S, Caley MP, Donaldson M, Enright AJ, O'Toole EA (2023).
1073:
1097:
2036:"SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects"
1794:"Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank"
203:
178:
4610:
4317:
4265:
4198:
3949:
3890:
4627:
1757:
Ghosh D (December 2004). "Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase".
1520:
3994:
3561:
3551:
2122:
Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol".
1370:
1366:
128:
4605:
4159:
3954:
3846:
3471:
3540:
3536:
3532:
3448:
3281:
216:
4270:
3802:
3748:
3708:
3667:
3571:
3410:
3378:
3264:
3228:
3134:
1496:
1294:
2334:"The enzymic hydrolysis of steroid conjugates. I. Sulphatase and β-glucuronidase activity of molluscan extracts"
209:
4172:
3456:
3305:
3219:
3113:
1491:
1091:
984:
1342:
in males. Both steroid sulfatase deficiency and common genetic risk variants within STS may confer increased
63:
3325:
3195:
2423:"Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis"
1351:
1078:
708:
1677:"Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues"
4667:
4241:
3881:
3520:
1210:
4203:
3816:
3713:
3505:
3466:
3330:
3252:
2035:
1279:
1142:
1066:
1843:
Wren G, Baker E, Underwood J, Humby T, Thompson A, Kirov G, Escott-Price V, Davies W (November 2022).
119:, ARSC, ARSC2, ARSC1, ASC, ES, SSDD, XLI, Steroid sulfatase (microsomal), isozyme S, steroid sulfatase
4375:
4256:
3999:
3834:
3829:
3762:
3422:
3247:
3127:
2808:
1486:
1255:
1001:
192:
115:
4246:
3854:
3824:
3628:
3623:
3547:
3483:
3269:
1409:
1343:
1335:
1320:
1289:
1259:
996:
878:
868:
864:
860:
856:
813:
803:
799:
795:
791:
2275:. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 22. pp. 205–35.
1094:
4561:
4077:
4069:
3987:
3839:
3320:
3310:
3188:
3090:
2939:
2832:
2787:
2680:
2642:
2575:
2306:
2147:
2104:
1355:
1018:
152:
4447:
2694:"Association of steroid sulfatase with one of the arylsulfatase C isozymes in human fibroblasts"
852:
787:
1982:"RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis"
4662:
4502:
4167:
4148:
3788:
3733:
3576:
3295:
3082:
3052:
3017:
2974:
2931:
2902:
2867:
2824:
2779:
2750:
2715:
2672:
2634:
2604:
2567:
2537:
2508:
2473:
2444:
2409:
2363:
2294:
2284:
2253:
2200:
2139:
2096:
2079:-sulfamates and their analogues: Clinical steroid sulfatase inhibitors with broad potential".
2057:
2013:
1962:
1913:
1876:
1825:
1774:
1739:
1698:
1657:
1606:
1405:
1197:
1085:
108:
56:
4580:
4100:
4053:
3864:
3444:
3349:
3344:
3300:
3109:
3074:
3042:
3007:
2999:
2964:
2923:
2892:
2857:
2816:
2771:
2740:
2705:
2664:
2626:
2596:
2559:
2529:
2498:
2465:
2434:
2399:
2353:
2345:
2276:
2243:
2235:
2190:
2182:
2131:
2088:
2047:
2003:
1993:
1952:
1944:
1903:
1866:
1856:
1815:
1805:
1766:
1729:
1688:
1647:
1637:
1596:
1588:
1397:
1243:
296:
227:
425:
418:
411:
17:
4332:
3966:
3780:
3696:
3691:
3686:
3599:
3594:
3354:
3232:
2386:
Elias PM, Crumrine D, Rassner U, Hachem JP, Menon GK, Man W, et al. (February 2004).
2318:
1626:"The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases"
1471:
1374:
1307:
1251:
1054:
271:
148:
2812:
2485:
Stein C, Hille A, Seidel J, Rijnbout S, Waheed A, Schmidt B, et al. (August 1989).
2008:
1981:
1871:
1844:
1675:
Miki Y, Nakata T, Suzuki T, Darnel AD, Moriya T, Kaneko C, et al. (December 2002).
1323:, a scaly-skin disease affecting roughly 1 in every 2,000 to 6,000 males. The excessive
1030:
4641:
4442:
4361:
4140:
3939:
3934:
3929:
3315:
3290:
3286:
3259:
3242:
3012:
2987:
2745:
2728:
2630:
2439:
2422:
2358:
2333:
2248:
2219:
2195:
2166:
1957:
1932:
1820:
1793:
1652:
1625:
1601:
1576:
1339:
1328:
1113:
989:
3078:
2710:
2693:
2600:
2503:
2486:
599:
594:
589:
584:
579:
574:
569:
553:
548:
543:
538:
533:
528:
523:
518:
513:
508:
492:
487:
482:
477:
467:
4651:
3680:
3589:
3339:
3047:
3030:
2969:
2952:
2943:
2668:
2563:
2533:
2469:
2404:
2387:
2239:
1426:
1382:
1378:
454:
3094:
2791:
2729:"Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase"
2684:
2646:
2579:
2151:
2108:
39:
4342:
3807:
3738:
3461:
3382:
2836:
1324:
1271:
1247:
289:
169:
1810:
3031:"Steroid sulfatase in the human hair follicle concentrates in the dermal papilla"
2988:"Deletion pattern of the STS gene in X-linked ichthyosis in a Mexican population"
2186:
1770:
156:
4458:
4370:
4285:
4218:
4129:
4111:
4061:
3982:
3753:
3647:
3510:
3476:
3414:
3180:
2522:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
2458:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
2092:
1948:
1542:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1275:
4636:
1998:
4228:
4049:
3959:
2388:"Basis for abnormal desquamation and permeability barrier dysfunction in RXLI"
2280:
2135:
1359:
1347:
186:
136:
2897:
2880:
1734:
1717:
1642:
1559:"Entrez Gene: STS steroid sulfatase (microsomal), arylsulfatase C, isozyme S"
4566:
4533:
4387:
4309:
3872:
3671:
3584:
3211:
2846:"Normalization and subtraction: two approaches to facilitate gene discovery"
1861:
1845:"Characterising heart rhythm abnormalities associated with Xp22.31 deletion"
1792:
Brcic L, Underwood JF, Kendall KM, Caseras X, Kirov G, Davies W (Mar 2020).
1401:
1386:
1283:
1193:
1170:
629:
389:
310:
255:
242:
144:
3086:
3056:
3021:
2978:
2935:
2413:
2367:
2298:
2257:
2204:
2100:
2061:
2017:
1966:
1917:
1880:
1829:
1778:
1702:
1693:
1676:
1661:
1610:
2928:
10.1002/(SICI)1098-1004(200003)15:3<296::AID-HUMU17>3.0.CO;2-#
2906:
2871:
2828:
2783:
2754:
2719:
2676:
2638:
2608:
2571:
2541:
2512:
2477:
2448:
2143:
1743:
957:
4525:
4468:
4383:
4095:
3917:
3912:
3907:
3728:
3363:
3215:
1592:
1177:
946:
751:
2052:
1908:
1895:
472:
4591:
4586:
4481:
4476:
4392:
4322:
4087:
4065:
3924:
3902:
3897:
3515:
3003:
2862:
2845:
2775:
1575:
Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA (October 2015).
1413:
1303:
1267:
1228:
1061:
1042:
737:
694:
2349:
85:
4512:
4507:
4435:
4430:
4057:
3944:
3877:
3770:
3368:
3276:
2820:
1173:
1125:
1037:
1025:
1013:
927:
651:
2692:
Chang PL, Varey PA, Rosa NE, Ameen M, Davidson RG (November 1986).
3886:
3637:
3633:
1288:
2421:
Basler E, Grompe M, Parenti G, Yates J, Ballabio A (March 1992).
2271:
Roy AB (1960). "The
Synthesis and Hydrolysis of Sulfate Esters".
1937:
JID Innovations: Skin
Science from Molecules to Population Health
614:
610:
3618:
3495:
3488:
3432:
3427:
1759:
Biochimica et
Biophysica Acta (BBA) - Molecular Basis of Disease
1350:
in STS deficiency may be related to abnormal development of the
1263:
1049:
132:
4022:
3184:
3123:
1577:"The Regulation of Steroid Action by Sulfation and Desulfation"
3119:
1931:
Brcic L, Wren GH, Underwood JF, Kirov G, Davies W (May 2022).
434:
2273:
Advances in
Enzymology and Related Areas of Molecular Biology
1242:
The protein encoded by this gene catalyzes the conversion of
3029:
Hoffmann R, Rot A, Niiyama S, Billich A (December 2001).
2171:-Sulfamate Pharmacophore for Oncology and Women's Health"
2081:
The
Journal of Steroid Biochemistry and Molecular Biology
1319:
A congenital deficiency in the enzyme is associated with
2124:
Acta
Obstetricia et Gynecologica Scandinavica Supplement
1214:
279:
4625:
3170:: Structure of Human Placental Estrone/DHEA Sulfatase
1570:
1568:
1278:, respectively). The encoded protein is found in the
1213:
401:
4540:
4496:
4488:
4424:
4399:
2951:
Oyama N, Satoh M, Iwatsuki K, Kaneko F (June 2000).
1681:
The
Journal of Clinical Endocrinology and Metabolism
4554:
4523:
4466:
4456:
4359:
4340:
4331:
4307:
4284:
4255:
4226:
4216:
4191:
4157:
4138:
4110:
4085:
4076:
3975:
3863:
3815:
3801:
3779:
3761:
3747:
3727:
3666:
3570:
3409:
3377:
3227:
2589:
Biochemical and Biophysical Research Communications
2332:Halkerston ID, Hillman J, Stitch SR (August 1956).
1136:
1124:
1112:
1107:
1084:
1072:
1060:
1048:
1036:
1024:
1012:
1007:
995:
983:
978:
973:
892:
851:
827:
786:
2844:Bonaldo MF, Lennon G, Soares MB (September 1996).
1516:
1514:
1512:
1219:
3506:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
2075:Thomas MP, Potter BV (September 2015). "Estrogen
1295:
226:
1933:"Comorbid Medical Issues in X-Linked Ichthyosis"
27:Protein-coding gene in the species Homo sapiens
1246:precursors to the free steroid. This includes
4034:
3196:
3135:
8:
1521:GRCh38: Ensembl release 89: ENSG00000101846
1234:Also acts on some related steryl sulfates.
1203:3β-hydroxyandrost-5-en-17-one 3-sulfate + H
4463:
4337:
4223:
4082:
4041:
4027:
4019:
3812:
3758:
3744:
3203:
3189:
3181:
3142:
3128:
3120:
1104:
848:
783:
625:
450:
267:
164:
74:
3112:at the U.S. National Library of Medicine
3046:
3011:
2968:
2896:
2861:
2744:
2709:
2502:
2438:
2403:
2357:
2247:
2194:
2051:
2007:
1997:
1956:
1907:
1870:
1860:
1819:
1809:
1733:
1692:
1651:
1641:
1600:
1212:
4237:Farnesyl-diphosphate farnesyltransferase
3035:The Journal of Investigative Dermatology
2957:The Journal of Investigative Dermatology
2392:The Journal of Investigative Dermatology
1553:
1551:
1440:dehydroepiandrosterone sulfate sulfatase
554:intracellular membrane-bounded organelle
4632:
4183:Isopentenyl-diphosphate delta isomerase
3396:Ubiquitin carboxy-terminal hydrolase L1
3157:
2167:"Discovery and Development of the Aryl
1508:
1468:3-beta-hydroxysteroid sulfate sulfatase
4601:Steroidogenic acute regulatory protein
2879:Alperin ES, Shapiro LJ (August 1997).
2314:
2304:
1716:Alperin ES, Shapiro LJ (August 1997).
970:
29:
3976:either deoxy- or ribo-
2727:Munroe DG, Chang PL (February 1987).
2165:Thomas MP, Potter BV (October 2015).
2029:
2027:
231:
190:
185:
7:
3557:Protein serine/threonine phosphatase
4178:Pyrophosphomevalonate decarboxylase
4096:Acetyl-Coenzyme A acetyltransferase
3658:Cyclic nucleotide phosphodiesterase
3652:Clostridium perfringens alpha toxin
3453:Tartrate-resistant acid phosphatase
2885:The Journal of Biological Chemistry
2698:The Journal of Biological Chemistry
2491:The Journal of Biological Chemistry
1722:The Journal of Biological Chemistry
1389:has been the most studied to date.
1262:, all to their unconjugated forms (
1220:{\displaystyle \rightleftharpoons }
575:glycosphingolipid metabolic process
3501:Pyruvate dehydrogenase phosphatase
2733:American Journal of Human Genetics
2631:10.1111/j.1399-0004.1988.tb02612.x
2427:American Journal of Human Genetics
2040:Journal of Molecular Endocrinology
1986:Frontiers in Molecular Biosciences
1424:Steryl-sulfatase is also known as
1302:activities for interconversion of
889:
824:
761:
742:
718:
699:
675:
656:
406:
367:
305:
284:
25:
3401:4-hydroxybenzoyl-CoA thioesterase
1300:Tooltip estrogen sulfotransferase
483:sulfuric ester hydrolase activity
345:lateral nuclear group of thalamus
4635:
3160:
3048:10.1046/j.0022-202x.2001.01547.x
2970:10.1046/j.1523-1747.2000.00004.x
2405:10.1046/j.1523-1747.2003.22258.x
1894:Wren GH, Davies W (April 2024).
1456:dehydroepiandrosterone sulfatase
1227:3β-hydroxyandrost-5-en-17-one +
1165:(EC 3.1.6.2), formerly known as
424:
417:
410:
215:
208:
202:
177:
38:
4351:Cholesterol side-chain cleavage
4295:24-Dehydrocholesterol reductase
4125:3-hydroxybutyrate dehydrogenase
3719:N-acetylglucosamine-6-sulfatase
3607:Sphingomyelin phosphodiesterase
4276:7-Dehydrocholesterol reductase
3528:Inositol-phosphate phosphatase
3391:Palmitoyl protein thioesterase
2175:Journal of Medicinal Chemistry
1452:steroid sulfate sulfohydrolase
1176:involved in the metabolism of
534:endoplasmic reticulum membrane
509:integral component of membrane
435:More reference expression data
390:More reference expression data
1:
4611:Reverse cholesterol transport
4199:Dimethylallyltranstransferase
3891:RNA-induced silencing complex
3079:10.1016/S0039-128X(02)00016-8
2711:10.1016/S0021-9258(18)66889-9
2601:10.1016/S0006-291X(87)80064-5
2504:10.1016/S0021-9258(18)80080-1
2228:Biochimica et Biophysica Acta
1811:10.1136/jmedgenet-2019-106676
1475:steryl-sulfate sulfohydrolase
1371:estrogen-dependent conditions
1310:(E1S) in adult human tissues.
200:
3995:Serratia marcescens nuclease
3562:Dual-specificity phosphatase
3552:Protein tyrosine phosphatase
2669:10.1016/0092-8674(88)90257-7
2564:10.1016/0092-8674(87)90447-8
2534:10.1016/0167-4838(89)90187-8
2470:10.1016/0167-4838(91)90566-I
2240:10.1016/0006-3002(54)90078-5
2187:10.1021/acs.jmedchem.5b00386
1771:10.1016/j.bbadis.2004.09.003
4658:Genes on human chromosome X
4606:Cholesterol total synthesis
3472:Fructose 1,6-bisphosphatase
2220:"The steroid sulphatase of
2093:10.1016/j.jsbmb.2015.03.012
1949:10.1016/j.xjidi.2022.100109
1849:Journal of Medical Genetics
1798:Journal of Medical Genetics
1282:, where it is present as a
524:endoplasmic reticulum lumen
18:Steroid sulfatase inhibitor
4684:
4318:Cholesterol 7α-hydroxylase
4266:Lanosterol 14α-demethylase
1999:10.3389/fmolb.2023.1176802
1464:phenolic steroid sulfatase
4271:Sterol-C5-desaturase-like
3709:Galactosamine-6 sulfatase
3265:6-phosphogluconolactonase
3155:
2281:10.1002/9780470122679.ch5
2136:10.3109/00016348409156994
2034:Potter BV (August 2018).
1630:Frontiers in Pharmacology
1538:"Human PubMed Reference:"
1497:Estrogen sulfotransferase
1103:
961:
956:
952:
945:
926:
909:
896:
875:
844:
831:
810:
779:
768:
764:
749:
745:
736:
725:
721:
706:
702:
693:
682:
678:
663:
659:
650:
635:
628:
624:
608:
590:steroid catabolic process
570:steroid metabolic process
478:steryl-sulfatase activity
453:
449:
432:
409:
400:
387:
374:
370:
317:
308:
278:
270:
266:
249:
236:
199:
176:
167:
163:
126:
123:
113:
106:
101:
82:
77:
60:
55:
50:
46:
37:
32:
4173:Phosphomevalonate kinase
3457:Purple acid phosphatases
3114:Medical Subject Headings
2898:10.1074/jbc.272.33.20756
1735:10.1074/jbc.272.33.20756
1643:10.3389/fphar.2016.00030
1492:Steroid sulfotransferase
1293:Distribution of STS and
2338:The Biochemical Journal
2218:Roy AB (October 1954).
1862:10.1136/jmg-2022-108862
1352:interventricular septum
1180:. It is encoded by the
4242:Squalene monooxygenase
3882:Microprocessor complex
3521:Beta-propeller phytase
1900:Essays in Biochemistry
1694:10.1210/jc.2002-020670
1460:pregnenolone sulfatase
1311:
1221:
493:arylsulfatase activity
337:pancreatic ductal cell
61:Human UniProt search:
4323:Sterol 27-hydroxylase
4204:Geranyl pyrophosphate
3817:Endodeoxyribonuclease
3714:Iduronate-2-sulfatase
3467:Glucose 6-phosphatase
3253:Butyrylcholinesterase
1315:Clinical significance
1292:
1280:endoplasmic reticulum
1222:
595:epidermis development
544:endoplasmic reticulum
353:primary visual cortex
349:middle temporal gyrus
329:palpebral conjunctiva
4257:7-Dehydrocholesterol
4000:Micrococcal nuclease
3835:Deoxyribonuclease IV
3830:Deoxyribonuclease II
3763:Exodeoxyribonuclease
3423:Alkaline phosphatase
3248:Acetylcholinesterase
1593:10.1210/er.2015-1036
1487:Steroidogenic enzyme
1470:, as well as by its
1256:pregnenolone sulfate
1211:
915:Chr X: 7.15 – 7.8 Mb
193:X chromosome (human)
78:List of PDB id codes
51:Available structures
4247:Lanosterol synthase
3855:UvrABC endonuclease
3825:Deoxyribonuclease I
3548:Protein phosphatase
3484:Protein phosphatase
3282:Bile salt-dependent
3270:PAF acetylhydrolase
2813:1982Natur.299..838M
2053:10.1530/JME-18-0045
1909:10.1042/EBC20230098
1448:steroid 3-sulfatase
1410:estradiol sulfamate
1344:atrial fibrillation
1336:atrial fibrillation
1321:X-linked ichthyosis
1260:cholesterol sulfate
4562:Steroid metabolism
4078:Mevalonate pathway
4070:steroid metabolism
3988:Mung bean nuclease
3847:Restriction enzyme
3840:Restriction enzyme
3004:10.1007/BF03401976
2992:Molecular Medicine
2863:10.1101/gr.6.9.791
2776:10.1007/bf00282842
1624:Rižner TL (2016).
1356:interatrial septum
1312:
1217:
563:Biological process
502:Cellular component
488:hydrolase activity
473:catalytic activity
461:Molecular function
4623:
4622:
4619:
4618:
4573:Steroid sulfatase
4550:
4549:
4303:
4302:
4212:
4211:
4168:Mevalonate kinase
4149:HMG-CoA reductase
4016:
4015:
4012:
4011:
4008:
4007:
3797:
3796:
3789:Oligonucleotidase
3734:deoxyribonuclease
3702:Steroid sulfatase
3577:Phosphodiesterase
3306:Hormone-sensitive
3178:
3177:
2619:Clinical Genetics
2350:10.1042/bj0630705
1581:Endocrine Reviews
1432:steroid sulfatase
1406:estrone sulfamate
1198:chemical reaction
1155:Steroid sulfatase
1152:
1151:
1148:
1147:
1067:metabolic pathway
969:
968:
965:
964:
941:
940:
905:
904:
886:
885:
840:
839:
821:
820:
775:
774:
758:
757:
732:
731:
715:
714:
689:
688:
672:
671:
620:
619:
468:metal ion binding
445:
444:
441:
440:
396:
395:
383:
382:
364:
363:
262:
261:
97:
96:
93:
92:
16:(Redirected from
4675:
4640:
4639:
4631:
4581:sulfotransferase
4542:
4498:
4490:
4464:
4426:
4401:
4338:
4224:
4103:(regulated step)
4101:HMG-CoA synthase
4083:
4054:lipid metabolism
4043:
4036:
4029:
4020:
3865:Endoribonuclease
3851:
3845:
3813:
3759:
3745:
3445:Acid phosphatase
3326:Monoacylglycerol
3236:ester hydrolases
3205:
3198:
3191:
3182:
3164:
3144:
3137:
3130:
3121:
3110:Steryl-Sulfatase
3098:
3060:
3050:
3025:
3015:
2982:
2972:
2947:
2910:
2900:
2891:(33): 20756–63.
2875:
2865:
2840:
2821:10.1038/299838a0
2807:(5886): 838–40.
2795:
2758:
2748:
2723:
2713:
2688:
2650:
2612:
2583:
2545:
2516:
2506:
2497:(23): 13865–72.
2481:
2452:
2442:
2417:
2407:
2372:
2371:
2361:
2329:
2323:
2322:
2316:
2312:
2310:
2302:
2268:
2262:
2261:
2251:
2215:
2209:
2208:
2198:
2162:
2156:
2155:
2119:
2113:
2112:
2072:
2066:
2065:
2055:
2046:(2): T233–T252.
2031:
2022:
2021:
2011:
2001:
1977:
1971:
1970:
1960:
1928:
1922:
1921:
1911:
1891:
1885:
1884:
1874:
1864:
1840:
1834:
1833:
1823:
1813:
1789:
1783:
1782:
1754:
1748:
1747:
1737:
1728:(33): 20756–63.
1713:
1707:
1706:
1696:
1672:
1666:
1665:
1655:
1645:
1621:
1615:
1614:
1604:
1572:
1563:
1562:
1555:
1546:
1545:
1534:
1528:
1518:
1436:sterol sulfatase
1301:
1297:
1244:sulfated steroid
1226:
1224:
1223:
1218:
1163:steryl-sulfatase
1105:
974:Steryl-sulfatase
971:
954:
953:
937:
922:
917:
900:
890:
881:
849:
845:RefSeq (protein)
835:
825:
816:
784:
762:
743:
719:
700:
676:
657:
626:
585:female pregnancy
580:lipid metabolism
451:
437:
428:
421:
414:
407:
392:
368:
357:Brodmann area 46
333:Brodmann area 23
325:endothelial cell
313:
311:Top expressed in
306:
285:
268:
258:
245:
234:
219:
212:
206:
195:
181:
165:
159:
118:
111:
88:
75:
69:
48:
47:
42:
30:
21:
4683:
4682:
4678:
4677:
4676:
4674:
4673:
4672:
4648:
4647:
4646:
4634:
4626:
4624:
4615:
4555:Other/ungrouped
4546:
4519:
4477:17α-Hydroxylase
4452:
4448:11β-Hydroxylase
4393:17α-Hydroxylase
4362:corticosteroids
4355:
4333:Steroidogenesis
4327:
4299:
4280:
4251:
4208:
4187:
4153:
4134:
4106:
4072:
4047:
4017:
4004:
3971:
3859:
3849:
3843:
3806:
3793:
3781:Exoribonuclease
3775:
3752:
3736:
3732:
3723:
3697:Arylsulfatase L
3692:Arylsulfatase B
3687:Arylsulfatase A
3662:
3575:
3566:
3405:
3373:
3235:
3223:
3209:
3179:
3174:
3171:
3165:
3151:
3148:
3106:
3101:
3063:
3028:
2985:
2950:
2913:
2878:
2850:Genome Research
2843:
2798:
2761:
2726:
2704:(31): 14443–7.
2691:
2653:
2615:
2586:
2548:
2519:
2484:
2455:
2420:
2385:
2381:
2379:Further reading
2376:
2375:
2331:
2330:
2326:
2313:
2303:
2291:
2270:
2269:
2265:
2222:Patella vulgata
2217:
2216:
2212:
2181:(19): 7634–58.
2164:
2163:
2159:
2121:
2120:
2116:
2074:
2073:
2069:
2033:
2032:
2025:
1979:
1978:
1974:
1930:
1929:
1925:
1893:
1892:
1888:
1842:
1841:
1837:
1804:(10): 692–698.
1791:
1790:
1786:
1756:
1755:
1751:
1715:
1714:
1710:
1674:
1673:
1669:
1623:
1622:
1618:
1574:
1573:
1566:
1557:
1556:
1549:
1536:
1535:
1531:
1519:
1510:
1505:
1483:
1472:systematic name
1444:arylsulfatase C
1422:
1400:of STS include
1395:
1375:prostate cancer
1317:
1308:estrone sulfate
1299:
1252:estrone sulfate
1240:
1209:
1208:
1206:
1190:
1167:arylsulfatase C
958:View/Edit Human
935:
920:
913:
910:Location (UCSC)
898:
877:
871:
867:
863:
859:
855:
833:
812:
806:
802:
798:
794:
790:
709:ENSG00000101846
604:
558:
539:plasma membrane
519:Golgi apparatus
497:
433:
423:
422:
416:
415:
388:
379:
360:
355:
351:
347:
343:
339:
335:
331:
327:
323:
309:
253:
240:
232:
222:
221:
220:
213:
191:
168:Gene location (
157:STS - orthologs
127:
114:
107:
84:
62:
28:
23:
22:
15:
12:
11:
5:
4681:
4679:
4671:
4670:
4665:
4660:
4650:
4649:
4645:
4644:
4621:
4620:
4617:
4616:
4614:
4613:
4608:
4603:
4597:
4596:
4595:
4594:
4589:
4577:
4576:
4575:
4558:
4556:
4552:
4551:
4548:
4547:
4545:
4544:
4536:
4530:
4528:
4521:
4520:
4518:
4517:
4516:
4515:
4510:
4500:
4492:
4484:
4479:
4473:
4471:
4461:
4454:
4453:
4451:
4450:
4445:
4443:21-Hydroxylase
4440:
4439:
4438:
4433:
4416:
4415:
4414:
4413:
4408:
4395:
4379:
4378:
4376:18-Hydroxylase
4366:
4364:
4357:
4356:
4354:
4353:
4347:
4345:
4335:
4329:
4328:
4326:
4325:
4320:
4314:
4312:
4305:
4304:
4301:
4300:
4298:
4297:
4291:
4289:
4282:
4281:
4279:
4278:
4273:
4268:
4262:
4260:
4253:
4252:
4250:
4249:
4244:
4239:
4233:
4231:
4221:
4214:
4213:
4210:
4209:
4207:
4206:
4201:
4195:
4193:
4189:
4188:
4186:
4185:
4180:
4175:
4170:
4164:
4162:
4155:
4154:
4152:
4151:
4145:
4143:
4141:Mevalonic acid
4136:
4135:
4133:
4132:
4127:
4122:
4116:
4114:
4108:
4107:
4105:
4104:
4098:
4092:
4090:
4080:
4074:
4073:
4048:
4046:
4045:
4038:
4031:
4023:
4014:
4013:
4010:
4009:
4006:
4005:
4003:
4002:
3997:
3992:
3991:
3990:
3979:
3977:
3973:
3972:
3970:
3969:
3964:
3963:
3962:
3957:
3952:
3947:
3937:
3932:
3927:
3922:
3921:
3920:
3915:
3910:
3905:
3895:
3894:
3893:
3884:
3869:
3867:
3861:
3860:
3858:
3857:
3852:
3837:
3832:
3827:
3821:
3819:
3810:
3799:
3798:
3795:
3794:
3792:
3791:
3785:
3783:
3777:
3776:
3774:
3773:
3767:
3765:
3756:
3742:
3725:
3724:
3722:
3721:
3716:
3711:
3706:
3705:
3704:
3699:
3694:
3689:
3676:
3674:
3664:
3663:
3661:
3660:
3655:
3645:
3640:
3631:
3626:
3621:
3616:
3615:
3614:
3604:
3603:
3602:
3597:
3587:
3581:
3579:
3568:
3567:
3565:
3564:
3559:
3554:
3545:
3544:
3543:
3525:
3524:
3523:
3513:
3508:
3503:
3498:
3493:
3492:
3491:
3481:
3480:
3479:
3469:
3464:
3459:
3442:
3441:
3440:
3435:
3430:
3419:
3417:
3407:
3406:
3404:
3403:
3398:
3393:
3387:
3385:
3375:
3374:
3372:
3371:
3366:
3360:
3359:
3358:
3357:
3352:
3347:
3336:
3335:
3334:
3333:
3331:Diacylglycerol
3328:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3284:
3273:
3272:
3267:
3262:
3260:Pectinesterase
3257:
3256:
3255:
3250:
3243:Cholinesterase
3239:
3237:
3225:
3224:
3210:
3208:
3207:
3200:
3193:
3185:
3176:
3175:
3173:
3172:
3166:
3159:
3156:
3153:
3152:
3149:
3147:
3146:
3139:
3132:
3124:
3118:
3117:
3105:
3104:External links
3102:
3100:
3099:
3061:
3026:
2983:
2948:
2916:Human Mutation
2911:
2876:
2856:(9): 791–806.
2841:
2796:
2770:(4): 446–447.
2764:Human Genetics
2759:
2724:
2689:
2663:(6): 1123–35.
2651:
2613:
2584:
2546:
2528:(3): 199–205.
2517:
2482:
2453:
2418:
2382:
2380:
2377:
2374:
2373:
2324:
2315:|journal=
2289:
2263:
2210:
2157:
2114:
2067:
2023:
1972:
1923:
1886:
1855:(7): 636–643.
1835:
1784:
1749:
1708:
1687:(12): 5760–8.
1667:
1616:
1564:
1547:
1529:
1507:
1506:
1504:
1501:
1500:
1499:
1494:
1489:
1482:
1479:
1421:
1418:
1412:(E2MATE), and
1394:
1391:
1346:risk. Cardiac
1340:atrial flutter
1329:hyperkeratosis
1316:
1313:
1239:
1236:
1232:
1231:
1216:
1204:
1196:the following
1189:
1186:
1150:
1149:
1146:
1145:
1140:
1134:
1133:
1128:
1122:
1121:
1116:
1110:
1109:
1101:
1100:
1089:
1082:
1081:
1076:
1070:
1069:
1064:
1058:
1057:
1052:
1046:
1045:
1040:
1034:
1033:
1028:
1022:
1021:
1016:
1010:
1009:
1005:
1004:
999:
993:
992:
987:
981:
980:
976:
975:
967:
966:
963:
962:
960:
950:
949:
943:
942:
939:
938:
933:
931:
924:
923:
918:
911:
907:
906:
903:
902:
894:
893:
887:
884:
883:
873:
872:
846:
842:
841:
838:
837:
829:
828:
822:
819:
818:
808:
807:
781:
777:
776:
773:
772:
766:
765:
759:
756:
755:
747:
746:
740:
734:
733:
730:
729:
723:
722:
716:
713:
712:
704:
703:
697:
691:
690:
687:
686:
680:
679:
673:
670:
669:
661:
660:
654:
648:
647:
642:
637:
633:
632:
622:
621:
618:
617:
606:
605:
603:
602:
597:
592:
587:
582:
577:
572:
566:
564:
560:
559:
557:
556:
551:
546:
541:
536:
531:
526:
521:
516:
511:
505:
503:
499:
498:
496:
495:
490:
485:
480:
475:
470:
464:
462:
458:
457:
447:
446:
443:
442:
439:
438:
430:
429:
404:
398:
397:
394:
393:
385:
384:
381:
380:
378:
375:
372:
371:
365:
362:
361:
359:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
315:
314:
302:
301:
293:
282:
276:
275:
272:RNA expression
264:
263:
260:
259:
251:
247:
246:
238:
235:
230:
224:
223:
214:
207:
201:
197:
196:
189:
183:
182:
174:
173:
161:
160:
125:
121:
120:
112:
104:
103:
99:
98:
95:
94:
91:
90:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4680:
4669:
4668:Endocrinology
4666:
4664:
4661:
4659:
4656:
4655:
4653:
4643:
4638:
4633:
4629:
4612:
4609:
4607:
4604:
4602:
4599:
4598:
4593:
4590:
4588:
4585:
4584:
4583:
4582:
4578:
4574:
4571:
4570:
4569:
4568:
4563:
4560:
4559:
4557:
4553:
4543:
4537:
4535:
4532:
4531:
4529:
4527:
4522:
4514:
4511:
4509:
4506:
4505:
4504:
4501:
4499:
4493:
4491:
4485:
4483:
4480:
4478:
4475:
4474:
4472:
4470:
4465:
4462:
4460:
4455:
4449:
4446:
4444:
4441:
4437:
4434:
4432:
4429:
4428:
4427:
4421:
4418:
4417:
4412:
4409:
4407:
4404:
4403:
4402:
4396:
4394:
4391:
4389:
4385:
4381:
4380:
4377:
4374:
4372:
4368:
4367:
4365:
4363:
4358:
4352:
4349:
4348:
4346:
4344:
4339:
4336:
4334:
4330:
4324:
4321:
4319:
4316:
4315:
4313:
4311:
4306:
4296:
4293:
4292:
4290:
4287:
4283:
4277:
4274:
4272:
4269:
4267:
4264:
4263:
4261:
4258:
4254:
4248:
4245:
4243:
4240:
4238:
4235:
4234:
4232:
4230:
4225:
4222:
4220:
4215:
4205:
4202:
4200:
4197:
4196:
4194:
4190:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4165:
4163:
4161:
4156:
4150:
4147:
4146:
4144:
4142:
4137:
4131:
4128:
4126:
4123:
4121:
4120:HMG-CoA lyase
4118:
4117:
4115:
4113:
4109:
4102:
4099:
4097:
4094:
4093:
4091:
4089:
4084:
4081:
4079:
4075:
4071:
4067:
4063:
4059:
4055:
4051:
4044:
4039:
4037:
4032:
4030:
4025:
4024:
4021:
4001:
3998:
3996:
3993:
3989:
3986:
3985:
3984:
3981:
3980:
3978:
3974:
3968:
3965:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3942:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3900:
3899:
3896:
3892:
3888:
3885:
3883:
3879:
3876:
3875:
3874:
3871:
3870:
3868:
3866:
3862:
3856:
3853:
3848:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3822:
3820:
3818:
3814:
3811:
3809:
3804:
3800:
3790:
3787:
3786:
3784:
3782:
3778:
3772:
3769:
3768:
3766:
3764:
3760:
3757:
3755:
3750:
3746:
3743:
3740:
3735:
3730:
3726:
3720:
3717:
3715:
3712:
3710:
3707:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3684:
3683:
3682:
3681:arylsulfatase
3678:
3677:
3675:
3673:
3669:
3665:
3659:
3656:
3653:
3649:
3646:
3644:
3641:
3639:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3613:
3610:
3609:
3608:
3605:
3601:
3598:
3596:
3593:
3592:
3591:
3590:Phospholipase
3588:
3586:
3583:
3582:
3580:
3578:
3573:
3569:
3563:
3560:
3558:
3555:
3553:
3549:
3546:
3542:
3538:
3534:
3531:
3530:
3529:
3526:
3522:
3519:
3518:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3490:
3487:
3486:
3485:
3482:
3478:
3475:
3474:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3454:
3450:
3446:
3443:
3439:
3436:
3434:
3431:
3429:
3426:
3425:
3424:
3421:
3420:
3418:
3416:
3412:
3408:
3402:
3399:
3397:
3394:
3392:
3389:
3388:
3386:
3384:
3380:
3376:
3370:
3367:
3365:
3362:
3361:
3356:
3353:
3351:
3348:
3346:
3343:
3342:
3341:
3340:Phospholipase
3338:
3337:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3288:
3285:
3283:
3280:
3279:
3278:
3275:
3274:
3271:
3268:
3266:
3263:
3261:
3258:
3254:
3251:
3249:
3246:
3245:
3244:
3241:
3240:
3238:
3234:
3230:
3226:
3221:
3217:
3213:
3206:
3201:
3199:
3194:
3192:
3187:
3186:
3183:
3169:
3163:
3158:
3154:
3145:
3140:
3138:
3133:
3131:
3126:
3125:
3122:
3115:
3111:
3108:
3107:
3103:
3096:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3062:
3058:
3054:
3049:
3044:
3041:(6): 1342–8.
3040:
3036:
3032:
3027:
3023:
3019:
3014:
3009:
3005:
3001:
2998:(12): 845–9.
2997:
2993:
2989:
2984:
2980:
2976:
2971:
2966:
2963:(6): 1195–9.
2962:
2958:
2954:
2949:
2945:
2941:
2937:
2933:
2929:
2925:
2921:
2917:
2912:
2908:
2904:
2899:
2894:
2890:
2886:
2882:
2877:
2873:
2869:
2864:
2859:
2855:
2851:
2847:
2842:
2838:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2797:
2793:
2789:
2785:
2781:
2777:
2773:
2769:
2765:
2760:
2756:
2752:
2747:
2742:
2739:(2): 102–14.
2738:
2734:
2730:
2725:
2721:
2717:
2712:
2707:
2703:
2699:
2695:
2690:
2686:
2682:
2678:
2674:
2670:
2666:
2662:
2658:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2624:
2620:
2614:
2610:
2606:
2602:
2598:
2595:(2): 1010–7.
2594:
2590:
2585:
2581:
2577:
2573:
2569:
2565:
2561:
2558:(4): 443–54.
2557:
2553:
2547:
2543:
2539:
2535:
2531:
2527:
2523:
2518:
2514:
2510:
2505:
2500:
2496:
2492:
2488:
2483:
2479:
2475:
2471:
2467:
2463:
2459:
2454:
2450:
2446:
2441:
2436:
2433:(3): 483–91.
2432:
2428:
2424:
2419:
2415:
2411:
2406:
2401:
2397:
2393:
2389:
2384:
2383:
2378:
2369:
2365:
2360:
2355:
2351:
2347:
2344:(4): 705–10.
2343:
2339:
2335:
2328:
2325:
2320:
2308:
2300:
2296:
2292:
2290:9780470122679
2286:
2282:
2278:
2274:
2267:
2264:
2259:
2255:
2250:
2245:
2241:
2237:
2233:
2229:
2225:
2223:
2214:
2211:
2206:
2202:
2197:
2192:
2188:
2184:
2180:
2176:
2172:
2170:
2161:
2158:
2153:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2118:
2115:
2110:
2106:
2102:
2098:
2094:
2090:
2086:
2082:
2078:
2071:
2068:
2063:
2059:
2054:
2049:
2045:
2041:
2037:
2030:
2028:
2024:
2019:
2015:
2010:
2005:
2000:
1995:
1991:
1987:
1983:
1976:
1973:
1968:
1964:
1959:
1954:
1950:
1946:
1943:(3): 100109.
1942:
1938:
1934:
1927:
1924:
1919:
1915:
1910:
1905:
1901:
1897:
1890:
1887:
1882:
1878:
1873:
1868:
1863:
1858:
1854:
1850:
1846:
1839:
1836:
1831:
1827:
1822:
1817:
1812:
1807:
1803:
1799:
1795:
1788:
1785:
1780:
1776:
1772:
1768:
1764:
1760:
1753:
1750:
1745:
1741:
1736:
1731:
1727:
1723:
1719:
1712:
1709:
1704:
1700:
1695:
1690:
1686:
1682:
1678:
1671:
1668:
1663:
1659:
1654:
1649:
1644:
1639:
1635:
1631:
1627:
1620:
1617:
1612:
1608:
1603:
1598:
1594:
1590:
1587:(5): 526–63.
1586:
1582:
1578:
1571:
1569:
1565:
1560:
1554:
1552:
1548:
1543:
1539:
1533:
1530:
1526:
1522:
1517:
1515:
1513:
1509:
1502:
1498:
1495:
1493:
1490:
1488:
1485:
1484:
1480:
1478:
1476:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1445:
1441:
1437:
1433:
1429:
1428:
1427:arylsulfatase
1419:
1417:
1415:
1411:
1407:
1403:
1399:
1392:
1390:
1388:
1384:
1383:endometriosis
1380:
1379:breast cancer
1376:
1372:
1368:
1363:
1361:
1357:
1353:
1349:
1345:
1341:
1337:
1332:
1330:
1326:
1322:
1314:
1309:
1305:
1298:
1291:
1287:
1285:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1237:
1235:
1230:
1202:
1201:
1200:
1199:
1195:
1187:
1185:
1183:
1179:
1175:
1172:
1168:
1164:
1160:
1156:
1144:
1141:
1139:
1135:
1132:
1129:
1127:
1123:
1120:
1117:
1115:
1111:
1106:
1102:
1099:
1096:
1093:
1090:
1087:
1083:
1080:
1077:
1075:
1071:
1068:
1065:
1063:
1059:
1056:
1053:
1051:
1047:
1044:
1043:NiceZyme view
1041:
1039:
1035:
1032:
1029:
1027:
1023:
1020:
1017:
1015:
1011:
1006:
1003:
1000:
998:
994:
991:
988:
986:
982:
977:
972:
959:
955:
951:
948:
944:
934:
932:
929:
925:
919:
916:
912:
908:
901:
895:
891:
888:
882:
880:
874:
870:
866:
862:
858:
854:
850:
847:
843:
836:
830:
826:
823:
817:
815:
809:
805:
801:
797:
793:
789:
785:
782:
780:RefSeq (mRNA)
778:
771:
767:
763:
760:
754:
753:
748:
744:
741:
739:
735:
728:
724:
720:
717:
711:
710:
705:
701:
698:
696:
692:
685:
681:
677:
674:
668:
667:
662:
658:
655:
653:
649:
646:
643:
641:
638:
634:
631:
627:
623:
616:
612:
607:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
567:
565:
562:
561:
555:
552:
550:
547:
545:
542:
540:
537:
535:
532:
530:
527:
525:
522:
520:
517:
515:
512:
510:
507:
506:
504:
501:
500:
494:
491:
489:
486:
484:
481:
479:
476:
474:
471:
469:
466:
465:
463:
460:
459:
456:
455:Gene ontology
452:
448:
436:
431:
427:
420:
413:
408:
405:
403:
399:
391:
386:
376:
373:
369:
366:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
319:
316:
312:
307:
304:
303:
300:
298:
294:
292:
291:
287:
286:
283:
281:
277:
273:
269:
265:
257:
252:
248:
244:
239:
229:
225:
218:
211:
205:
198:
194:
188:
184:
180:
175:
171:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
122:
117:
110:
105:
100:
89:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
4579:
4572:
4565:
4503:5α-Reductase
4459:sex hormones
4419:
4382:
4369:
4343:pregnenolone
3850:}}
3844:{{
3808:Endonuclease
3739:ribonuclease
3701:
3679:
3462:Nucleotidase
3383:Thioesterase
3167:
3073:(7): 655–9.
3070:
3066:
3038:
3034:
2995:
2991:
2960:
2956:
2919:
2915:
2888:
2884:
2853:
2849:
2804:
2800:
2767:
2763:
2736:
2732:
2701:
2697:
2660:
2656:
2622:
2618:
2592:
2588:
2555:
2551:
2525:
2521:
2494:
2490:
2464:(2): 251–7.
2461:
2457:
2430:
2426:
2398:(2): 314–9.
2395:
2391:
2341:
2337:
2327:
2272:
2266:
2234:(2): 300–1.
2231:
2227:
2221:
2213:
2178:
2174:
2168:
2160:
2127:
2123:
2117:
2084:
2080:
2076:
2070:
2043:
2039:
1989:
1985:
1975:
1940:
1936:
1926:
1899:
1889:
1852:
1848:
1838:
1801:
1797:
1787:
1762:
1758:
1752:
1725:
1721:
1711:
1684:
1680:
1670:
1633:
1629:
1619:
1584:
1580:
1541:
1532:
1474:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1425:
1423:
1396:
1364:
1333:
1325:skin scaling
1318:
1272:pregnenolone
1248:DHEA sulfate
1241:
1233:
1192:This enzyme
1191:
1181:
1166:
1162:
1158:
1154:
1153:
1031:BRENDA entry
897:
879:NP_001307683
876:
869:NP_001307682
865:NP_001307681
861:NP_001307680
857:NP_001307679
832:
814:NM_001320754
811:
804:NM_001320753
800:NM_001320752
796:NM_001320751
792:NM_001320750
769:
750:
726:
707:
683:
664:
644:
639:
295:
288:
124:External IDs
83:
4482:17,20-Lyase
4371:aldosterone
4286:Desmosterol
4219:cholesterol
4130:Thiophorase
4112:Ketogenesis
4062:cholesterol
3983:Nuclease S1
3754:Exonuclease
3648:Lecithinase
3477:Calcineurin
3415:Phosphatase
3321:Lipoprotein
3311:Endothelial
3150:PDB gallery
2625:(1): 31–7.
1992:: 1176802.
1276:cholesterol
1019:IntEnz view
979:Identifiers
102:Identifiers
4652:Categories
4310:Bile acids
4229:lanosterol
4064:synthesis
4050:Metabolism
3296:Pancreatic
3233:Carboxylic
2922:(3): 296.
2130:: 107–11.
1765:(1): 1–4.
1527:, May 2017
1503:References
1398:Inhibitors
1393:Inhibitors
1360:hemostasis
1348:arrhythmia
1088:structures
1055:KEGG entry
1002:9025-62-1
600:metabolism
299:(ortholog)
254:7,804,358
241:7,147,237
137:HomoloGene
4567:sulfatase
4534:Aromatase
4526:estrogens
4469:androgens
4388:cortisone
3873:RNase III
3731:(includes
3672:Sulfatase
3585:Autotaxin
3449:Prostatic
3301:Lysosomal
3216:esterases
3212:Hydrolase
2944:196599371
2317:ignored (
2307:cite book
2087:: 160–9.
1408:(EMATE),
1402:irosustat
1387:Irosustat
1367:androgen-
1306:(E1) and
1284:homodimer
1215:⇌
1194:catalyses
1188:Reactions
1171:sulfatase
1008:Databases
853:NP_000342
788:NM_000351
630:Orthologs
145:GeneCards
4663:EC 3.1.6
4384:cortisol
4192:Geranyl-
3967:RNase T1
3729:Nuclease
3364:Cutinase
3095:11872655
3087:11996939
3067:Steroids
3057:11886493
3022:11844872
2979:10844566
2936:10679952
2792:23372914
2685:42065481
2647:39954996
2580:23353934
2414:15009711
2368:13355874
2299:13744184
2258:13208702
2205:25992880
2152:45817485
2109:24116740
2101:25843211
2062:29618488
2018:37363400
2009:10285781
1967:35330591
1918:38571328
1881:36379544
1872:10359567
1830:32139392
1779:15607112
1703:12466383
1662:26924986
1611:26213785
1523:–
1481:See also
1362:in XLI.
1238:Function
1178:steroids
1143:proteins
1131:articles
1119:articles
1092:RCSB PDB
947:Wikidata
609:Sources:
549:lysosome
529:membrane
514:endosome
321:placenta
4642:Biology
4592:SULT2A1
4587:SULT1A1
4088:HMG-CoA
4066:enzymes
4058:ketones
3940:RNase E
3935:RNase Z
3930:RNase A
3925:RNase P
3898:RNase H
3516:Phytase
3316:Hepatic
3291:Lingual
3287:Gastric
3013:1950010
2907:9252398
2872:8889548
2837:4361097
2829:6957717
2809:Bibcode
2784:6948769
2755:3471087
2746:1684069
2720:3464600
2677:3203382
2639:3165728
2609:3034252
2572:3032454
2542:2765556
2513:2668275
2478:2065092
2449:1539590
2440:1684279
2359:1216242
2249:1274509
2196:5159624
2144:6238495
1958:8938907
1821:7525778
1744:9252398
1653:4757672
1602:4591525
1525:Ensembl
1414:danazol
1304:estrone
1268:estrone
1229:sulfate
1169:, is a
1079:profile
1062:MetaCyc
997:CAS no.
990:3.1.6.2
738:UniProt
695:Ensembl
636:Species
615:QuickGO
341:decidua
274:pattern
233:Xp22.31
109:Aliases
4628:Portal
3878:Drosha
3803:3.1.21
3771:RecBCD
3749:3.1.11
3369:PETase
3277:Lipase
3116:(MeSH)
3093:
3085:
3055:
3020:
3010:
2977:
2942:
2934:
2905:
2870:
2835:
2827:
2801:Nature
2790:
2782:
2753:
2743:
2718:
2683:
2675:
2645:
2637:
2607:
2578:
2570:
2540:
2511:
2476:
2447:
2437:
2412:
2366:
2356:
2297:
2287:
2256:
2246:
2203:
2193:
2150:
2142:
2107:
2099:
2060:
2016:
2006:
1965:
1955:
1916:
1879:
1869:
1828:
1818:
1777:
1742:
1701:
1660:
1650:
1636:: 30.
1609:
1599:
1274:, and
1258:, and
1184:gene.
1174:enzyme
1161:), or
1126:PubMed
1108:Search
1098:PDBsum
1038:ExPASy
1026:BRENDA
1014:IntEnz
985:EC no.
930:search
928:PubMed
752:P08842
652:Entrez
402:BioGPS
133:300747
4420:both:
4160:DMAPP
3887:Dicer
3842:;see
3668:3.1.6
3638:PDE4B
3634:PDE4A
3572:3.1.4
3541:IMPA3
3537:IMPA2
3533:IMPA1
3411:3.1.3
3379:3.1.2
3229:3.1.1
3091:S2CID
2940:S2CID
2833:S2CID
2788:S2CID
2681:S2CID
2643:S2CID
2576:S2CID
2148:S2CID
2105:S2CID
1420:Names
1373:like
1074:PRIAM
645:Mouse
640:Human
611:Amigo
297:Mouse
290:Human
237:Start
170:Human
141:47918
4539:17β-
4495:17β-
4398:11β-
4288:path
4259:path
3805:-31:
3751:-16:
3737:and
3643:PDE5
3629:PDE3
3624:PDE2
3619:PDE1
3511:PTEN
3496:OCRL
3489:PP2A
3438:ALPP
3433:ALPL
3428:ALPI
3222:3.1)
3168:1p49
3083:PMID
3053:PMID
3018:PMID
2975:PMID
2932:PMID
2903:PMID
2868:PMID
2825:PMID
2780:PMID
2751:PMID
2716:PMID
2673:PMID
2657:Cell
2635:PMID
2605:PMID
2568:PMID
2552:Cell
2538:PMID
2509:PMID
2474:PMID
2462:1078
2445:PMID
2410:PMID
2364:PMID
2319:help
2295:PMID
2285:ISBN
2254:PMID
2201:PMID
2140:PMID
2097:PMID
2058:PMID
2014:PMID
1963:PMID
1914:PMID
1877:PMID
1826:PMID
1775:PMID
1763:1739
1740:PMID
1699:PMID
1658:PMID
1607:PMID
1369:and
1327:and
1264:DHEA
1138:NCBI
1095:PDBe
1050:KEGG
280:Bgee
228:Band
187:Chr.
129:OMIM
86:1P49
67:RCSB
64:PDBe
4541:HSD
4524:To
4497:HSD
4489:HSD
4487:3β-
4467:To
4457:To
4425:HSD
4423:3β-
4400:HSD
4360:To
4341:To
4308:To
4227:To
4217:To
4158:To
4139:To
4086:To
3960:4/5
3075:doi
3043:doi
3039:117
3008:PMC
3000:doi
2965:doi
2961:114
2924:doi
2893:doi
2889:272
2858:doi
2817:doi
2805:299
2772:doi
2741:PMC
2706:doi
2702:261
2665:doi
2627:doi
2597:doi
2593:144
2560:doi
2530:doi
2526:997
2499:doi
2495:264
2466:doi
2435:PMC
2400:doi
2396:122
2354:PMC
2346:doi
2277:doi
2244:PMC
2236:doi
2191:PMC
2183:doi
2132:doi
2128:123
2089:doi
2085:153
2048:doi
2004:PMC
1994:doi
1953:PMC
1945:doi
1904:doi
1867:PMC
1857:doi
1816:PMC
1806:doi
1767:doi
1730:doi
1726:272
1689:doi
1648:PMC
1638:doi
1597:PMC
1589:doi
1354:or
1338:or
1296:EST
1182:STS
1159:STS
1114:PMC
1086:PDB
936:n/a
921:n/a
899:n/a
834:n/a
770:n/a
727:n/a
684:n/a
666:412
377:n/a
250:End
153:OMA
149:STS
116:STS
57:PDB
33:STS
4654::
4564::
4056:–
4052::
3918:2C
3913:2B
3908:2A
3889::
3880::
3670::
3550::
3539:,
3535:,
3451:)/
3413::
3381::
3350:A2
3345:A1
3231::
3220:EC
3214::
3089:.
3081:.
3071:67
3069:.
3051:.
3037:.
3033:.
3016:.
3006:.
2994:.
2990:.
2973:.
2959:.
2955:.
2938:.
2930:.
2920:15
2918:.
2901:.
2887:.
2883:.
2866:.
2852:.
2848:.
2831:.
2823:.
2815:.
2803:.
2786:.
2778:.
2768:58
2766:.
2749:.
2737:40
2735:.
2731:.
2714:.
2700:.
2696:.
2679:.
2671:.
2661:55
2659:.
2641:.
2633:.
2623:34
2621:.
2603:.
2591:.
2574:.
2566:.
2556:49
2554:.
2536:.
2524:.
2507:.
2493:.
2489:.
2472:.
2460:.
2443:.
2431:50
2429:.
2425:.
2408:.
2394:.
2390:.
2362:.
2352:.
2342:63
2340:.
2336:.
2311::
2309:}}
2305:{{
2293:.
2283:.
2252:.
2242:.
2232:15
2230:.
2226:.
2199:.
2189:.
2179:58
2177:.
2173:.
2146:.
2138:.
2126:.
2103:.
2095:.
2083:.
2056:.
2044:61
2042:.
2038:.
2026:^
2012:.
2002:.
1990:10
1988:.
1984:.
1961:.
1951:.
1939:.
1935:.
1912:.
1902:.
1898:.
1875:.
1865:.
1853:60
1851:.
1847:.
1824:.
1814:.
1802:57
1800:.
1796:.
1773:.
1761:.
1738:.
1724:.
1720:.
1697:.
1685:87
1683:.
1679:.
1656:.
1646:.
1632:.
1628:.
1605:.
1595:.
1585:36
1583:.
1579:.
1567:^
1550:^
1540:.
1511:^
1477:.
1466:,
1462:,
1458:,
1454:,
1450:,
1446:,
1442:,
1438:,
1434:,
1430:,
1404:,
1381:,
1377:,
1286:.
1270:,
1266:,
1254:,
1250:,
1207:O
613:/
256:bp
243:bp
151:;
147::
143:;
139::
135:;
131::
4630::
4513:2
4508:1
4436:2
4431:1
4411:2
4406:1
4390::
4386:/
4373::
4068:/
4060:/
4042:e
4035:t
4028:v
3955:3
3950:2
3945:1
3903:1
3741:)
3654:)
3650:(
3636:/
3612:1
3600:D
3595:C
3574::
3455:/
3447:(
3355:B
3289:/
3218:(
3204:e
3197:t
3190:v
3143:e
3136:t
3129:v
3097:.
3077::
3059:.
3045::
3024:.
3002::
2996:7
2981:.
2967::
2946:.
2926::
2909:.
2895::
2874:.
2860::
2854:6
2839:.
2819::
2811::
2794:.
2774::
2757:.
2722:.
2708::
2687:.
2667::
2649:.
2629::
2611:.
2599::
2582:.
2562::
2544:.
2532::
2515:.
2501::
2480:.
2468::
2451:.
2416:.
2402::
2370:.
2348::
2321:)
2301:.
2279::
2260:.
2238::
2224:"
2207:.
2185::
2169:O
2154:.
2134::
2111:.
2091::
2077:O
2064:.
2050::
2020:.
1996::
1969:.
1947::
1941:2
1920:.
1906::
1883:.
1859::
1832:.
1808::
1781:.
1769::
1746:.
1732::
1705:.
1691::
1664:.
1640::
1634:7
1613:.
1591::
1561:.
1544:.
1205:2
1157:(
172:)
155::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
