223:
429:
4859:
419:, one of the last steps in cholesterol biosynthesis, and were formerly used to treat hypercholesterolemia, but were withdrawn from the market due to toxicity caused by accumulation of desmosterol in tissues.
2805:
3857:"5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons"
544:(though ultimately have never been marketed for this indication), and trilostane was formerly used to inhibit corticosteroid synthesis in the treatment of Cushing's syndrome.
669:
prevent the production of the potent mineralocorticoid aldosterone from the less potent mineralocorticoid corticosterone. Osilodrostat was investigated for the treatment of
572:
inhibit the production of androgens and glucocorticoids and are used to reduce androgen levels in the treatment of prostate cancer. Selective 17,20-lyase inhibitors such as
992:
310:(FPP), a mid-range step in the biosynthesis of cholesterol from acetyl-CoA, and thereby inhibit cholesterol production. They notably do not significantly lower
314:
levels of cholesterol however, and hence, unlike statins, are not suitable for the treatment of hypercholesterolemia. The main examples of FPPS inhibitors are
206:
4891:
3816:"Inhibitors of sterol synthesis. Metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intravenous administration to bile duct-cannulated rats"
2965:
2781:
1354:
3801:"9α-hydroxy-3-oxo-4,24(25)-stigmastadien-26-oic acid derivatives, a process for preparing same and pharmaceutical compositions containing same"
1191:
815:
457:
1658:
4839:
4557:
4530:
4503:
4476:
4449:
4368:
4341:
4314:
4257:
4227:
4200:
4173:
4135:
4089:
4016:
3989:
3962:
3930:
3784:
3757:
3728:
3698:
250:
576:
inhibit only androgen production without affecting glucocorticoid synthesis and are under development for the treatment of prostate cancer.
4863:
388:
5314:
2585:
2061:
1671:
691:
5225:
5069:
5028:
4782:
Thomas MP, Potter BV (2015). "Estrogen O-sulfamates and their analogues: Clinical steroid sulfatase inhibitors with broad potential".
2372:
1295:
497:
2335:
1578:
5177:
4994:
4249:
Hormonal
Steroids Biochemistry, Pharmacology, and Therapeutics: Proceedings of the First International Congress on Hormonal Steroids
1059:
395:. 7-DHCR inhibitors produce an acquired form of SLOS in animals, and as such, like 24-DHCR inhibitors (see below), are probably too
5186:
3283:
2190:
2243:
1498:
5100:
4884:
2577:
1646:
1225:
1221:
1151:
404:
299:
1494:
1234:
5146:
5053:
3569:
3097:
3017:
1662:
1115:
759:
364:
2797:
5240:
5074:
3265:
2476:
2402:
895:
767:
5273:
5265:
4706:
Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol".
751:
3643:"Neurosteroids, GABAA receptors and neurosteroid based drugs: are we witnessing the dawn of the new psychiatric drugs?"
5169:
5159:
5141:
5082:
4986:
2431:
1590:
1406:
1069:
829:(SST) inhibitors prevent the conversion of steroid hormones such as estrone and DHEA into hormonally inactive steroid
246:
2541:
2198:
5023:
4965:
4928:
4877:
2545:
2525:
2398:
1776:
1706:
1702:
1485:
1477:
1473:
1465:
1325:
1321:
602:
594:
3595:
Vanden
Bossche H (1992). "Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment".
1920:
5112:
4978:
3003:
2533:
2390:
2230:
2178:
2170:
2166:
1077:
723:
380:
303:
3038:
5245:
5107:
2994:
2705:
2645:
1734:
826:
485:
3425:
3238:
2214:
4391:"Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies"
1238:
5220:
5198:
5164:
4923:
3429:
3377:
2861:
1992:
74:
1710:
476:
from cholesterol and thereby prevent the synthesis of all steroid hormones. They have been used to inhibit
5181:
5151:
5117:
5090:
5002:
4918:
3814:
Schroepfer GJ, Chu AJ, Needleman DH, Izumi A, Nguyen PT, Wang KS, Little JM, Sherrill BC, Kisic A (1988).
3101:
3013:
2889:
2079:
1996:
1875:
1772:
1481:
1329:
1217:
1213:
1081:
1073:
699:
642:
537:
307:
291:
4468:
Yen & Jaffe's
Reproductive Endocrinology E-Book: Physiology, Pathophysiology, and Clinical Management
2885:
2529:
5230:
3287:
3242:
3186:
2961:
2957:
2677:
2537:
2275:
1242:
971:
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2222:
2206:
481:
3309:
2673:
3868:
3564:
3113:
3042:
2901:
2845:
2681:
2553:
2410:
2347:
2158:
2048:
1969:
1948:
1125:
834:
771:
654:
392:
376:
283:
3497:
2605:
5095:
5010:
3505:
3329:
3321:
3130:
3089:
2613:
2549:
2406:
2307:
2299:
2255:
2186:
1900:
1849:
1698:
1542:
1510:
1382:
1366:
975:
854:
791:
755:
747:
695:
553:
198:
4276:
Ray S, Sharma I (1987). "Development of progesterone antagonists as fertility regulating agents".
3545:
3541:
3445:
3385:
3361:
3357:
3305:
2617:
2311:
2154:
4933:
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4731:
4647:
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3533:
3481:
3477:
3413:
3393:
3341:
3313:
3301:
3122:
2953:
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2945:
2941:
2921:
2809:
2508:
783:
3469:
3365:
2841:
2589:
2116:
1862:
1594:
3030:
1936:
5203:
4835:
4829:
4799:
4761:
4723:
4688:
4639:
4604:
4553:
4526:
4499:
4472:
4445:
4420:
4364:
4358:
4337:
4310:
4304:
4285:
4253:
4247:
4223:
4217:
4196:
4190:
4169:
4163:
4131:
4125:
4085:
4079:
4055:
4012:
4006:
3985:
3979:
3958:
3952:
3926:
3920:
3896:
3837:
3780:
3774:
3753:
3724:
3718:
3694:
3688:
3664:
3612:
3146:
3134:
3079:
3066:
2597:
2557:
2247:
2132:
2128:
2124:
2000:
1904:
1892:
1785:
1642:
1502:
1358:
1246:
1138:
858:
850:
795:
779:
703:
549:
461:
372:
263:
202:
183:
175:
59:
4547:
4520:
4493:
4466:
4439:
4331:
3747:
3158:
3142:
1714:
1638:
1530:
1182:
1134:
368:
4938:
4904:
4791:
4715:
4678:
4631:
4594:
4586:
4410:
4402:
4045:
3886:
3876:
3827:
3654:
3604:
3449:
3256:
3154:
3150:
3034:
2817:
2394:
2174:
2083:
2024:
1928:
1883:
1825:
1780:
1582:
1337:
1274:
980:
763:
646:
190:
116:
4752:
Sadozai H (2013). "Steroid sulfatase inhibitors: promising new therapy for breast cancer".
2857:
2853:
2849:
814:
inhibit the production of estrogens from androgens and are used mainly in the treatment of
222:
5208:
5015:
3199:
3105:
3025:
2512:
2504:
2484:
2287:
2234:
2218:
2182:
2087:
1489:
1349:
1333:
1106:
1102:
1098:
1094:
1090:
1086:
870:
774:
from progesterone, 11-deoxycorticosterone, and DHT, respectively, which may contribute to
489:
440:
432:
287:
139:
124:
2267:
2141:
877:
into their hormonally active forms. They have potential applications in the treatment of
532:
and thereby inhibit the production of most of the steroid hormones. Due to inhibition of
488:, and ketoconazole has also been used to inhibit androgen production in the treatment of
4622:
Gibbs TT, Russek SJ, Farb DH (2006). "Sulfated steroids as endogenous neuromodulators".
3872:
5061:
5048:
4955:
4599:
4574:
4415:
4390:
3409:
2717:
2653:
2323:
2194:
2052:
1983:
1952:
1879:
1841:
1755:
1630:
1418:
1345:
1282:
1009:
985:
634:
586:
525:
477:
318:
259:
171:
167:
3891:
3856:
3832:
3815:
209:, steroidogenesis inhibitors directly inhibit the enzymatic biosynthesis of steroids.
5308:
5191:
3608:
3509:
3493:
3489:
3421:
3397:
3381:
3353:
3337:
2929:
2829:
2657:
2649:
2565:
2303:
1726:
1622:
1430:
947:
931:
882:
878:
818:
678:
674:
541:
201:; whereas antigonadotropins suppress gonadal production of sex steroids by effecting
64:
4811:
4735:
4651:
4900:
3624:
3537:
3517:
3501:
3485:
3461:
3453:
3441:
3437:
3417:
3405:
3389:
3369:
3345:
3333:
3297:
3252:
3211:
3207:
3195:
3117:
3062:
2925:
2909:
2801:
2765:
2761:
2745:
2625:
2601:
2516:
2500:
2271:
2263:
2238:
2226:
2162:
2091:
2044:
2032:
2004:
1960:
1924:
1821:
1801:
1768:
1746:
1738:
1654:
1614:
1602:
1574:
1534:
1469:
1461:
1438:
1426:
1422:
1402:
1341:
1317:
1313:
1270:
1229:
1046:
1038:
1018:
1014:
919:
911:
907:
899:
874:
842:
838:
811:
743:
707:
670:
666:
626:
614:
590:
565:
533:
473:
465:
436:
342:
275:
267:
266:(acetyl-CoA), and thereby decrease cholesterol levels. Examples of statins include
229:
179:
128:
83:
4869:
5038:
4795:
3529:
3525:
3521:
3513:
3473:
3465:
3433:
3401:
3349:
3234:
3191:
3182:
3093:
2917:
2913:
2877:
2869:
2865:
2789:
2757:
2741:
2729:
2697:
2561:
2456:
2444:
2440:
2427:
2355:
2339:
2331:
2319:
2291:
2283:
2259:
2251:
2210:
2120:
2040:
2020:
2016:
1987:
1896:
1853:
1845:
1817:
1789:
1722:
1718:
1650:
1626:
1570:
1538:
1514:
1506:
1410:
1378:
1370:
1362:
1258:
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1209:
1170:
1165:
1161:
1129:
1050:
1042:
1026:
1022:
903:
799:
775:
739:
735:
731:
727:
638:
606:
573:
529:
509:
501:
444:
416:
408:
351:
338:
334:
330:
326:
322:
315:
279:
226:
163:
151:
143:
3922:
Metabolic
Diseases: Foundations of Clinical Management, Genetics, and Pathology
4719:
4635:
4406:
3800:
3457:
3325:
3317:
3291:
3279:
2873:
2825:
2821:
2793:
2785:
2749:
2725:
2713:
2709:
2641:
2633:
2629:
2609:
2593:
2581:
2573:
2492:
2452:
2448:
2436:
2415:
2359:
2343:
2315:
2295:
2036:
2008:
1956:
1940:
1932:
1833:
1829:
1793:
1634:
1618:
1606:
1598:
1566:
1562:
1522:
1518:
1434:
1414:
1398:
1286:
1178:
1142:
1034:
1030:
943:
927:
923:
915:
803:
658:
618:
561:
521:
428:
412:
271:
233:
132:
28:
4059:
3668:
5131:
4050:
4033:
3659:
3642:
3373:
3246:
3203:
3138:
3070:
3054:
2986:
2982:
2978:
2905:
2897:
2881:
2837:
2833:
2813:
2777:
2773:
2769:
2737:
2721:
2693:
2669:
2665:
2661:
2637:
2621:
2569:
2520:
2496:
2463:
2423:
2351:
2327:
2099:
2028:
2012:
1916:
1912:
1908:
1837:
1813:
1809:
1797:
1730:
1693:
1610:
1586:
1558:
1554:
1550:
1526:
1394:
1266:
1254:
1174:
951:
862:
807:
715:
610:
569:
557:
4803:
4765:
4692:
4643:
4608:
4424:
3881:
3616:
4858:
4727:
4289:
3900:
3855:
Schroepfer GJ, Parish EJ, Kisic A, Jackson EM, Farley CM, Mott GE (1982).
3841:
95:
4590:
3050:
2974:
2937:
2933:
2753:
2733:
2689:
2685:
2419:
2279:
2202:
1944:
1887:
1805:
1742:
1689:
1390:
1374:
1278:
939:
662:
630:
622:
517:
513:
505:
469:
159:
155:
4683:
4666:
4008:
Tietz
Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book
3167:
3126:
3109:
3058:
3021:
2893:
2701:
2488:
2112:
2108:
2104:
2095:
1546:
1447:
1386:
1262:
1005:
930:. Ergosterol is absent in animals but is an essential component of the
866:
830:
711:
135:
79:
41:
4970:
4005:
Carl A. Burtis; Edward R. Ashwood; David E. Bruns (14 October 2012).
3220:
966:
147:
120:
67:
589:(CYP21A2) inhibitors prevent the production of corticosteroids from
4330:
William D. Figg; Cindy H. Chau; Eric J. Small (14 September 2010).
5255:
3046:
935:
649:
and are used in the diagnosis and treatment of
Cushing's syndrome.
427:
396:
262:, a relatively early step in the biosynthesis of cholesterol from
194:
3954:
Cholesterol: Its
Functions and Metabolism in Biology and Medicine
3919:
E. Gilbert-Barness; L.A. Barness; P.M. Farrell (6 January 2017).
3717:
Frank J. Dowd; Bart
Johnson; Angelo Mariotti (3 September 2016).
2969:
2363:
384:
112:
4873:
4575:"The Regulation of Steroid Action by Sulfation and Desulfation"
4573:
Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA (2015).
4216:
Waun Ki Hong; American
Association for Cancer Research (2010).
833:. Although hormonally inactive, some steroid sulfates, such as
1192:
189:
Steroidogenesis inhibitors are analogous in effect and use to
3914:
3912:
3910:
3776:
General and
Molecular Pharmacology: Principles of Drug Action
885:, and are currently under investigation for such indications.
251:
4306:
Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment
942:, and so lanosterol 14α-demethylase inhibitors are used as
46:
Steroid biosynthesis inhibitor; Steroid synthesis inhibitor
4189:
Dimitrios A. Linos; Jon A. van Heerden (5 December 2005).
4525:. Springer Science & Business Media. pp. 46–50.
4336:. Springer Science & Business Media. pp. 96–98.
1060:
681:, but development for these indications was discontinued.
4465:
Jerome F. Strauss; Robert L. Barbieri (28 August 2013).
4309:. Springer Science & Business Media. pp. 157–.
4195:. Springer Science & Business Media. pp. 171–.
3957:. Springer Science & Business Media. pp. 130–.
2062:
1672:
350:
Other early-stage cholesterol synthesis inhibitors like
4498:. Springer Science & Business Media. pp. 79–.
4444:. Springer Science & Business Media. pp. 39–.
4192:
Adrenal Glands: Diagnostic Aspects and Surgical Therapy
4165:
Cytochrome P450: Structure, Mechanism, and Biochemistry
4081:
Principles and Practice of Endocrinology and Metabolism
3773:
Francesco Clementi; Guido Fumagalli (9 February 2015).
2373:
1296:
1152:
1116:
1070:
Dimethylallyl pyrophosphate (isoprenyl pyrophosphate)
629:
inhibit the production of the potent corticosteroids
379:, one of the last steps in cholesterol biosynthesis.
4124:
J. Larry Jameson; Leslie J. De Groot (18 May 2010).
4084:. Lippincott Williams & Wilkins. pp. 735–.
3720:
Pharmacology and Therapeutics for Dentistry - E-Book
5282:
5254:
5130:
5037:
4954:
4947:
4911:
4119:
4117:
4115:
4113:
4111:
4109:
4107:
4105:
4103:
4101:
3636:
3634:
869:inhibit the conversion of steroid sulfates such as
249:, also known as statins, prevent the conversion of
89:
73:
58:
50:
40:
35:
21:
4834:. Jones & Bartlett Publishers. pp. 292–.
4828:Tekoa L. King; Mary C. Brucker (25 October 2010).
4823:
4821:
4034:"Diagram of the pathways of human steroidogenesis"
197:sex steroid production), but work via a different
4157:
4155:
4153:
4151:
4149:
4147:
3712:
3710:
3004:
452:Non-specific steroid hormone synthesis inhibitors
182:. They are used in the treatment of a variety of
2995:
550:17α-Hydroxylase/17,20-lyase (CYP17A1) inhibitors
4777:
4775:
4747:
4745:
4495:Female Alopecia: Guide to Successful Management
4384:
4382:
4380:
3752:. Elsevier Science. 17 May 2017. pp. 88–.
3682:
3680:
3678:
1993:18-Ethynylprogesterone (18-ethinylprogesterone)
4271:
4269:
4241:
4239:
4130:. Elsevier Health Sciences. pp. 301–302.
3946:
3944:
3942:
3742:
3740:
3690:Comprehensive Dermatologic Drug Therapy E-Book
3590:
3588:
3586:
3584:
1197:Tooltip Cholesterol side-chain cleavage enzyme
4885:
4162:Paul R. Ortiz de Montellano (13 March 2015).
4073:
4071:
4069:
536:biosynthesis, they have been investigated as
256:Tooltip 3-hydroxy-3-methylglutaryl-coenzyme A
8:
4471:. Elsevier Health Sciences. pp. 81–82.
3749:Nuclear Receptors in Development and Disease
581:Corticosteroid-specific synthesis inhibitors
302:(FPPS) inhibitors prevent the conversion of
4127:Endocrinology - E-Book: Adult and Pediatric
4011:. Elsevier Health Sciences. pp. 733–.
3723:. Elsevier Health Sciences. pp. 426–.
3693:. Elsevier Health Sciences. pp. 415–.
3284:4,4-Dimethylcholesta-8(9),14,24-trien-3β-ol
415:inhibit the production of cholesterol from
375:inhibit the production of cholesterol from
4951:
4892:
4878:
4870:
4682:
4598:
4414:
4049:
3890:
3880:
3831:
3658:
3080:
1065:Tooltip Farnesyl pyrophosphate synthetase
686:Sex steroid-specific synthesis inhibitors
4303:Marcello D. Bronstein (1 October 2010).
3779:. John Wiley & Sons. pp. 442–.
3687:Stephen E. Wolverton (18 October 2012).
3641:Tvrdeić, Ante; Poljak, Ljiljana (2016).
3139:Irosustat (STX64, 667 Coumate, BN-83495)
2067:Tooltip 17β-Hydroxysteroid dehydrogenase
1677:Tooltip 11β-Hydroxysteroid dehydrogenase
962:
286:for the purpose of lowering the risk of
221:
4665:Prough RA, Clark BJ, Klinge CM (2016).
3981:Advances in Lipid Research: Skin Lipids
3580:
2378:Tooltip 3α-Hydroxysteroid dehydrogenase
1301:Tooltip 3β-Hydroxysteroid dehydrogenase
1157:Tooltip 24-Dehydrocholesterol reductase
750:(DHT) and are used in the treatment of
4441:Regulation of Aldosterone Biosynthesis
1121:Tooltip 7-Dehydrocholesterol reductase
760:inhibit the formation of neurosteroids
758:(pattern hair loss). These drugs also
460:(P450scc, CYP11A1) inhibitors such as
458:Cholesterol side-chain cleavage enzyme
18:
959:List of steroid metabolism modulators
641:from the less potent corticosteroids
341:, which are used in the treatment of
142:. They may inhibit the production of
7:
4549:Endocrine Therapies in Breast Cancer
4357:Stephen Neidle (30 September 2013).
424:Steroid hormone synthesis inhibitors
391:(SLOS) and dramatic accumulation of
359:Lanosterol to cholesterol inhibitors
282:. They are used in the treatment of
247:HMG-CoA reductase (HMGCR) inhibitors
186:that depend on endogenous steroids.
123:that are involved in the process of
4492:Ralph M. Trüeb (26 February 2013).
3951:Robert Bittman (11 November 2013).
241:Acetyl-CoA to lanosterol inhibitors
207:hypothalamic–pituitary–gonadal axis
4667:"Novel mechanisms for DHEA action"
4546:Aman U. Buzdar (8 November 2007).
4333:Drug Management of Prostate Cancer
3978:Peter M. Elias (21 January 2016).
890:Other steroid synthesis inhibitors
14:
4389:Fleseriu M, Castinetti F (2016).
4363:. Academic Press. pp. 341–.
4032:Häggström M, Richfield D (2014).
3647:Endocrine Oncology and Metabolism
3039:2,6-Dichloro-4-nitrophenol (DCNP)
3009:Tooltip Estrogen sulfotransferase
698:conversion of the weak androgens
694:(17β-HSD) inhibitors prevent the
4857:
4519:Rob Bradbury (30 January 2007).
4360:Cancer Drug Design and Discovery
3000:Tooltip Steroid sulfotransferase
2870:Rogletimide (pyridoglutethimide)
1739:Glycyrrhizin (glycyrrhizic acid)
692:17β-Hydroxysteroid dehydrogenase
218:Cholesterol synthesis inhibitors
4831:Pharmacology for Women's Health
4708:Acta Obstet Gynecol Scand Suppl
4438:Jürg Müller (6 December 2012).
3925:. IOS Press. pp. 336–337.
1731:Enoxolone (glycyrrhetinic acid)
524:inhibit the conversion of Δ-3β-
498:3β-Hydroxysteroid dehydrogenase
405:24-Dehydrocholesterol reductase
300:Farnesyl pyrophosphate synthase
205:on and thereby suppressing the
4552:. OUP Oxford. pp. 37–40.
4219:Holland-Frei Cancer Medicine 8
4168:. Springer. pp. 851–879.
3570:Neurosteroidogenesis inhibitor
3098:Dehydroepiandrosterone sulfate
3018:Dehydroepiandrosterone sulfate
746:into the more potent androgen
714:into the more potent estrogen
706:into the more potent androgen
480:synthesis in the treatment of
365:7-Dehydrocholesterol reductase
109:steroid biosynthesis inhibitor
1:
4784:J. Steroid Biochem. Mol. Biol
4246:L Martini (2 December 2012).
3833:10.1016/S0021-9258(18)68897-0
3597:J. Steroid Biochem. Mol. Biol
2191:5α-Dihydrodeoxycorticosterone
898:(CYP51A1) inhibitors such as
768:tetrahydrodeoxycorticosterone
657:(CYP11B2) inhibitors such as
605:(CYP11B1) inhibitors such as
407:(24-DHCR) inhibitors such as
3861:Proc. Natl. Acad. Sci. U.S.A
3609:10.1016/0960-0760(92)90328-G
3131:Estradiol sulfamate (E2MATE)
1226:20α,22R-Dihydroxycholesterol
1222:20α,22R-Dihydroxycholesterol
752:benign prostatic hyperplasia
500:(3β-HSD) inhibitors such as
367:(7-DHCR) inhibitors such as
193:(which specifically inhibit
4796:10.1016/j.jsbmb.2015.03.012
4252:. Elsevier. pp. 383–.
4222:. PMPH-USA. pp. 756–.
3984:. Elsevier. pp. 218–.
2432:Medroxyprogesterone acetate
1407:Medroxyprogesterone acetate
5331:
5315:Steroidogenesis inhibitors
5070:Dihydropteroate synthetase
4929:Non-competitive inhibition
4864:Steroidogenesis inhibitors
4078:Kenneth L. Becker (2001).
3522:Terconazole (triaconazole)
2477:16α-Hydroxyandrostenedione
922:prevent the production of
896:Lanosterol 14α-demethylase
816:estrogen receptor-positive
742:prevent the conversion of
472:inhibit the production of
389:Smith–Lemli–Opitz syndrome
387:encoding 7-DHCR result in
381:Loss-of-function mutations
5290:Steroidogenesis inhibitor
4720:10.3109/00016348409156994
4636:10.1016/j.pbb.2006.07.031
4624:Pharmacol. Biochem. Behav
4407:10.1007/s11102-016-0742-1
3135:Estrone sulfamate (EMATE)
3085:Tooltip Steroid sulfatase
1078:Isopentenyl pyrophosphate
853:(STS) inhibitors such as
304:isopentenyl pyrophosphate
213:Types, examples, and uses
105:steroidogenesis inhibitor
94:
26:
22:Steroidogenesis inhibitor
5226:Matrix metalloproteinase
5029:Ribonucleotide reductase
4924:Uncompetitive inhibition
3426:Isavuconazonium chloride
2862:Resorcylic acid lactones
2646:conjugated linoleic acid
2199:5α-Dihydrocorticosterone
1735:Epigallocatechin gallate
827:Steroid sulfotransferase
486:adrenocortical carcinoma
4995:Dihydrofolate reductase
4038:WikiJournal of Medicine
3430:Isavuconazonium sulfate
3378:Econazole/triamcinolone
3067:Pentachlorophenol (PCP)
2546:20α-Dihydroprogesterone
1777:17α-Hydroxyprogesterone
1707:11β-Hydroxyprogesterone
1703:11α-Hydroxyprogesterone
1486:17α-Hydroxyprogesterone
1478:17α-Hydroxypregnenolone
1474:17α-Hydroxyprogesterone
1466:17α-Hydroxypregnenolone
1326:17α-Hydroxyprogesterone
1322:17α-Hydroxypregnenolone
1239:3,3′-Dimethoxybenzidine
724:5α-Reductase inhibitors
595:17α-hydroxyprogesterone
5091:Nucleotidyltransferase
4919:Competitive inhibition
3882:10.1073/pnas.79.9.3042
3102:Dehydroepiandrosterone
3014:Dehydroepiandrosterone
2534:4'-Hydroxynorendoxifen
2391:5α-Dihydroprogesterone
2231:5α-Dihydrotestosterone
2179:3β-Dihydroprogesterone
2171:3α-Dihydroprogesterone
2167:5α-Dihydroprogesterone
2080:Dehydroepiandrosterone
1876:11-Deoxycorticosterone
1773:11-Deoxycorticosterone
1482:Dehydroepiandrosterone
1330:Dehydroepiandrosterone
1218:22R-Hydroxycholesterol
1214:22R-Hydroxycholesterol
1082:Farnesyl pyrophosphate
1074:Farnesyl pyrophosphate
710:and the weak estrogen
700:dehydroepiandrosterone
643:11-deoxycorticosterone
448:
399:to be used clinically.
308:farnesyl pyrophosphate
292:cardiovascular disease
237:
5101:Reverse transcriptase
4051:10.15347/wjm/2014.005
3660:10.21040/eom/2016.2.7
3239:7α-Hydroxycholesterol
3187:27-Hydroxycholesterol
2538:4-Hydroxytestosterone
2276:Chlormadinone acetate
2215:5α-Dihydroaldosterone
1711:18α-Glycyrrhizic acid
431:
225:
5147:Acetylcholinesterase
5054:Thymidylate synthase
4866:at Wikimedia Commons
4591:10.1210/er.2015-1036
3565:Steroidogenic enzyme
3114:Pregnenolone sulfate
3043:7,8-Dihydroxyflavone
2890:(–)-dehydrololiolide
2554:alpha-Naphthoflavone
2348:Saw palmetto extract
2049:Potassium canrenoate
1997:18-Vinylprogesterone
1949:Potassium canrenoate
1126:7-Dehydrocholesterol
950:in the treatment of
835:pregnenolone sulfate
792:Aromatase inhibitors
655:Aldosterone synthase
393:7-dehydrocholesterol
377:7-dehydrocholesterol
284:hypercholesterolemia
5241:Histone deacetylase
5075:Farnesyltransferase
4684:10.1530/JME-16-0013
3873:1982PNAS...79.3042S
3090:Cholesterol sulfate
2886:dehydroabietic acid
2818:PGE2 (dinoprostone)
2530:4-Cyclohexylaniline
2407:Dihydrotestosterone
2256:Abiraterone acetate
2187:Deoxycorticosterone
1901:Abiraterone acetate
1850:Abiraterone acetate
1699:11-Ketoprogesterone
1543:Cyproterone acetate
1511:Abiraterone acetate
1383:Cyproterone acetate
1367:Abiraterone acetate
855:estradiol sulfamate
756:androgenic alopecia
748:dihydrotestosterone
554:abiraterone acetate
199:mechanism of action
119:one or more of the
5274:Carbonic anhydrase
5266:Dopa decarboxylase
4934:Suicide inhibition
4671:J. Mol. Endocrinol
2962:monodictyochrome B
2958:monodictyochrome A
2678:7-hydroxyflavanone
2509:Methyltestosterone
2481:16α-Hydroxyestrone
2223:5α-Androstanedione
2207:5α-Dihydrocortisol
1243:3-Methoxybenzidine
784:sexual dysfunction
482:Cushing's syndrome
449:
238:
184:medical conditions
176:mineralocorticoids
107:, also known as a
5302:
5301:
5298:
5297:
5170:Alpha-glucosidase
5160:Polygalacturonase
5142:Phosphodiesterase
5083:GABA transaminase
4987:Monoamine oxidase
4971:HMG-CoA reductase
4905:enzyme inhibition
4862:Media related to
4841:978-1-4496-5800-7
4559:978-0-19-921814-1
4532:978-3-540-33120-9
4505:978-3-642-35503-5
4478:978-1-4557-5972-9
4451:978-3-642-96062-8
4370:978-0-12-397228-6
4343:978-1-60327-829-4
4316:978-1-60327-449-4
4259:978-0-323-14465-0
4229:978-1-60795-014-1
4202:978-3-540-26861-1
4175:978-3-319-12108-6
4137:978-1-4557-1126-0
4091:978-0-7817-1750-2
4018:978-1-4557-5942-2
3991:978-1-4832-1545-7
3964:978-1-4615-5901-6
3932:978-1-61499-718-4
3786:978-1-118-76857-0
3759:978-0-12-802196-5
3730:978-0-323-44595-5
3700:978-1-4557-3801-4
3553:
3552:
3276:
3231:
3179:
2598:isoliquiritigenin
2558:Aminoglutethimide
2473:
2411:3α-Androstanediol
2387:
2151:
2076:
2001:Aminoglutethimide
1980:
1905:Aminoglutethimide
1872:
1786:Aminoglutethimide
1765:
1686:
1458:
1310:
1247:Aminoglutethimide
1206:
1002:
993:HMG-CoA reductase
859:estrone sulfamate
851:Steroid sulfatase
796:aminoglutethimide
772:3α-androstanediol
726:(5-ARIs) such as
704:4-androstenedione
462:aminoglutethimide
264:acetyl coenzyme A
203:negative feedback
191:antigonadotropins
101:
100:
60:Biological target
36:Class identifiers
5322:
5024:Xanthine oxidase
4966:Aldose reductase
4952:
4939:Mixed inhibition
4894:
4887:
4880:
4871:
4861:
4846:
4845:
4825:
4816:
4815:
4779:
4770:
4769:
4749:
4740:
4739:
4703:
4697:
4696:
4686:
4662:
4656:
4655:
4619:
4613:
4612:
4602:
4570:
4564:
4563:
4543:
4537:
4536:
4516:
4510:
4509:
4489:
4483:
4482:
4462:
4456:
4455:
4435:
4429:
4428:
4418:
4386:
4375:
4374:
4354:
4348:
4347:
4327:
4321:
4320:
4300:
4294:
4293:
4273:
4264:
4263:
4243:
4234:
4233:
4213:
4207:
4206:
4186:
4180:
4179:
4159:
4142:
4141:
4121:
4096:
4095:
4075:
4064:
4063:
4053:
4029:
4023:
4022:
4002:
3996:
3995:
3975:
3969:
3968:
3948:
3937:
3936:
3916:
3905:
3904:
3894:
3884:
3852:
3846:
3845:
3835:
3811:
3805:
3804:
3797:
3791:
3790:
3770:
3764:
3763:
3744:
3735:
3734:
3714:
3705:
3704:
3684:
3673:
3672:
3662:
3638:
3629:
3628:
3592:
3450:Levoketoconazole
3310:Arasertaconazole
3270:
3257:Levoketoconazole
3225:
3173:
3086:
3082:
3035:6-Hydroxyflavone
3010:
3006:
3001:
2997:
2674:7-hydroxyflavone
2467:
2395:Allopregnanolone
2381:
2379:
2375:
2308:γ-linolenic acid
2300:α-linolenic acid
2175:Allopregnanolone
2145:
2084:5-Androstenediol
2070:
2068:
2064:
1974:
1929:Levoketoconazole
1884:11-Deoxycortisol
1866:
1826:Levoketoconazole
1781:11-Deoxycortisol
1759:
1680:
1678:
1674:
1583:Levoketoconazole
1452:
1448:17α-Hydroxylase,
1338:5-Androstenediol
1304:
1302:
1298:
1275:Levoketoconazole
1200:
1198:
1194:
1158:
1154:
1122:
1118:
1066:
1062:
996:
963:
841:, are important
764:allopregnanolone
647:11-deoxycortisol
441:steroid hormones
257:
253:
140:steroid hormones
19:
5330:
5329:
5325:
5324:
5323:
5321:
5320:
5319:
5305:
5304:
5303:
5294:
5278:
5250:
5126:
5113:Tyrosine kinase
5033:
4943:
4907:
4898:
4854:
4849:
4842:
4827:
4826:
4819:
4781:
4780:
4773:
4754:J Pak Med Assoc
4751:
4750:
4743:
4705:
4704:
4700:
4664:
4663:
4659:
4621:
4620:
4616:
4572:
4571:
4567:
4560:
4545:
4544:
4540:
4533:
4518:
4517:
4513:
4506:
4491:
4490:
4486:
4479:
4464:
4463:
4459:
4452:
4437:
4436:
4432:
4388:
4387:
4378:
4371:
4356:
4355:
4351:
4344:
4329:
4328:
4324:
4317:
4302:
4301:
4297:
4275:
4274:
4267:
4260:
4245:
4244:
4237:
4230:
4215:
4214:
4210:
4203:
4188:
4187:
4183:
4176:
4161:
4160:
4145:
4138:
4123:
4122:
4099:
4092:
4077:
4076:
4067:
4031:
4030:
4026:
4019:
4004:
4003:
3999:
3992:
3977:
3976:
3972:
3965:
3950:
3949:
3940:
3933:
3918:
3917:
3908:
3854:
3853:
3849:
3813:
3812:
3808:
3799:
3798:
3794:
3787:
3772:
3771:
3767:
3760:
3746:
3745:
3738:
3731:
3716:
3715:
3708:
3701:
3686:
3685:
3676:
3640:
3639:
3632:
3594:
3593:
3582:
3578:
3561:
3555:
3268:14α-demethylase
3267:
3222:
3200:Dexmedetomidine
3172:
3169:
3106:Estrone sulfate
3084:
3026:Estrone sulfate
3008:
2999:
2846:triptoquinone A
2513:Methylestradiol
2505:Methylestradiol
2485:Androstenedione
2466:
2380:
2377:
2288:Epitestosterone
2235:Androstadienone
2219:Androstenedione
2183:Isopregnanolone
2159:5α-Cholestanone
2144:
2088:Androstenedione
2069:
2066:
1971:
1865:
1863:11β-Hydroxylase
1758:
1679:
1676:
1490:Androstenedione
1449:
1350:Androstadienone
1334:Androstenedione
1303:
1300:
1199:
1196:
1156:
1120:
1107:Zoledronic acid
1103:Risedronic acid
1099:Pamidronic acid
1095:Incadronic acid
1091:Ibandronic acid
1087:Alendronic acid
1064:
995:
961:
892:
871:estrone sulfate
688:
603:11β-Hydroxylase
583:
526:hydroxysteroids
490:prostate cancer
454:
433:Steroidogenesis
426:
361:
319:bisphosphonates
288:atherosclerosis
255:
243:
220:
215:
172:glucocorticoids
168:corticosteroids
125:steroidogenesis
111:, is a type of
17:
12:
11:
5:
5328:
5326:
5318:
5317:
5307:
5306:
5300:
5299:
5296:
5295:
5293:
5292:
5286:
5284:
5280:
5279:
5277:
5276:
5269:
5268:
5261:
5259:
5252:
5251:
5249:
5248:
5246:Beta-lactamase
5243:
5236:
5235:
5234:
5233:
5228:
5223:
5213:
5212:
5211:
5206:
5196:
5195:
5194:
5189:
5173:
5172:
5167:
5162:
5155:
5154:
5149:
5144:
5137:
5135:
5128:
5127:
5125:
5124:
5123:
5122:
5121:
5120:
5108:Protein kinase
5105:
5104:
5103:
5098:
5086:
5085:
5078:
5077:
5072:
5065:
5064:
5057:
5056:
5051:
5044:
5042:
5035:
5034:
5032:
5031:
5026:
5019:
5018:
5013:
5006:
5005:
4998:
4997:
4990:
4989:
4982:
4981:
4974:
4973:
4968:
4961:
4959:
4956:Oxidoreductase
4949:
4945:
4944:
4942:
4941:
4936:
4931:
4926:
4921:
4915:
4913:
4909:
4908:
4899:
4897:
4896:
4889:
4882:
4874:
4868:
4867:
4853:
4852:External links
4850:
4848:
4847:
4840:
4817:
4771:
4741:
4698:
4677:(3): R139–55.
4657:
4614:
4565:
4558:
4538:
4531:
4511:
4504:
4484:
4477:
4457:
4450:
4430:
4401:(6): 643–653.
4376:
4369:
4349:
4342:
4322:
4315:
4295:
4284:(10): 656–61.
4265:
4258:
4235:
4228:
4208:
4201:
4181:
4174:
4143:
4136:
4097:
4090:
4065:
4024:
4017:
3997:
3990:
3970:
3963:
3938:
3931:
3906:
3847:
3826:(9): 4110–23.
3806:
3792:
3785:
3765:
3758:
3736:
3729:
3706:
3699:
3674:
3630:
3603:(8): 1003–21.
3579:
3577:
3574:
3573:
3572:
3567:
3560:
3557:
3551:
3550:
3548:
3498:Quilseconazole
3410:Fosfluconazole
3295:
3277:
3262:
3261:
3259:
3250:
3232:
3223:7α-hydroxylase
3217:
3216:
3214:
3189:
3180:
3170:27-hydroxylase
3164:
3163:
3161:
3120:
3087:
3076:
3075:
3073:
3028:
3011:
2991:
2990:
2972:
2718:liquiritigenin
2654:linolenic acid
2606:Corynesidone A
2523:
2474:
2460:
2459:
2434:
2413:
2388:
2369:
2368:
2366:
2324:Ganoderic acid
2241:
2195:Corticosterone
2152:
2138:
2137:
2135:
2102:
2077:
2058:
2057:
2055:
2053:Spironolactone
1990:
1984:Corticosterone
1981:
1966:
1965:
1963:
1953:Spironolactone
1890:
1880:Corticosterone
1873:
1859:
1858:
1856:
1842:Spironolactone
1783:
1766:
1756:21-Hydroxylase
1752:
1751:
1749:
1696:
1687:
1668:
1667:
1665:
1631:Spironolactone
1492:
1459:
1444:
1443:
1441:
1419:Norethisterone
1352:
1346:Androstadienol
1311:
1292:
1291:
1289:
1283:Spironolactone
1232:
1207:
1188:
1187:
1185:
1168:
1159:
1148:
1147:
1145:
1132:
1123:
1112:
1111:
1109:
1084:
1067:
1056:
1055:
1053:
1012:
1010:Mevalonic acid
1003:
989:
988:
983:
978:
969:
960:
957:
956:
955:
948:antiprotozoals
932:cell membranes
891:
888:
887:
886:
847:
846:
823:
822:
794:(AIs) such as
788:
787:
720:
719:
687:
684:
683:
682:
651:
650:
635:corticosterone
599:
598:
587:21-Hydroxylase
582:
579:
578:
577:
546:
545:
542:abortifacients
538:contraceptives
494:
493:
478:corticosteroid
453:
450:
425:
422:
421:
420:
401:
400:
360:
357:
356:
355:
347:
346:
296:
295:
260:mevalonic acid
242:
239:
219:
216:
214:
211:
99:
98:
92:
91:
87:
86:
77:
75:Chemical class
71:
70:
62:
56:
55:
52:
48:
47:
44:
38:
37:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5327:
5316:
5313:
5312:
5310:
5291:
5288:
5287:
5285:
5283:Miscellaneous
5281:
5275:
5271:
5270:
5267:
5263:
5262:
5260:
5257:
5253:
5247:
5244:
5242:
5238:
5237:
5232:
5229:
5227:
5224:
5222:
5221:Enkephalinase
5219:
5218:
5217:
5214:
5210:
5207:
5205:
5202:
5201:
5200:
5199:Endopeptidase
5197:
5193:
5190:
5188:
5185:
5184:
5183:
5179:
5175:
5174:
5171:
5168:
5166:
5165:Neuraminidase
5163:
5161:
5157:
5156:
5153:
5150:
5148:
5145:
5143:
5139:
5138:
5136:
5133:
5129:
5119:
5116:
5115:
5114:
5111:
5110:
5109:
5106:
5102:
5099:
5097:
5094:
5093:
5092:
5088:
5087:
5084:
5080:
5079:
5076:
5073:
5071:
5067:
5066:
5063:
5059:
5058:
5055:
5052:
5050:
5046:
5045:
5043:
5040:
5036:
5030:
5027:
5025:
5021:
5020:
5017:
5014:
5012:
5008:
5007:
5004:
5000:
4999:
4996:
4992:
4991:
4988:
4984:
4983:
4980:
4976:
4975:
4972:
4969:
4967:
4963:
4962:
4960:
4957:
4953:
4950:
4946:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4916:
4914:
4910:
4906:
4902:
4895:
4890:
4888:
4883:
4881:
4876:
4875:
4872:
4865:
4860:
4856:
4855:
4851:
4843:
4837:
4833:
4832:
4824:
4822:
4818:
4813:
4809:
4805:
4801:
4797:
4793:
4789:
4785:
4778:
4776:
4772:
4767:
4763:
4760:(4): 509–15.
4759:
4755:
4748:
4746:
4742:
4737:
4733:
4729:
4725:
4721:
4717:
4713:
4709:
4702:
4699:
4694:
4690:
4685:
4680:
4676:
4672:
4668:
4661:
4658:
4653:
4649:
4645:
4641:
4637:
4633:
4630:(4): 555–67.
4629:
4625:
4618:
4615:
4610:
4606:
4601:
4596:
4592:
4588:
4585:(5): 526–63.
4584:
4580:
4576:
4569:
4566:
4561:
4555:
4551:
4550:
4542:
4539:
4534:
4528:
4524:
4523:
4515:
4512:
4507:
4501:
4497:
4496:
4488:
4485:
4480:
4474:
4470:
4469:
4461:
4458:
4453:
4447:
4443:
4442:
4434:
4431:
4426:
4422:
4417:
4412:
4408:
4404:
4400:
4396:
4392:
4385:
4383:
4381:
4377:
4372:
4366:
4362:
4361:
4353:
4350:
4345:
4339:
4335:
4334:
4326:
4323:
4318:
4312:
4308:
4307:
4299:
4296:
4291:
4287:
4283:
4279:
4272:
4270:
4266:
4261:
4255:
4251:
4250:
4242:
4240:
4236:
4231:
4225:
4221:
4220:
4212:
4209:
4204:
4198:
4194:
4193:
4185:
4182:
4177:
4171:
4167:
4166:
4158:
4156:
4154:
4152:
4150:
4148:
4144:
4139:
4133:
4129:
4128:
4120:
4118:
4116:
4114:
4112:
4110:
4108:
4106:
4104:
4102:
4098:
4093:
4087:
4083:
4082:
4074:
4072:
4070:
4066:
4061:
4057:
4052:
4047:
4043:
4039:
4035:
4028:
4025:
4020:
4014:
4010:
4009:
4001:
3998:
3993:
3987:
3983:
3982:
3974:
3971:
3966:
3960:
3956:
3955:
3947:
3945:
3943:
3939:
3934:
3928:
3924:
3923:
3915:
3913:
3911:
3907:
3902:
3898:
3893:
3888:
3883:
3878:
3874:
3870:
3867:(9): 3042–6.
3866:
3862:
3858:
3851:
3848:
3843:
3839:
3834:
3829:
3825:
3821:
3820:J. Biol. Chem
3817:
3810:
3807:
3802:
3796:
3793:
3788:
3782:
3778:
3777:
3769:
3766:
3761:
3755:
3751:
3750:
3743:
3741:
3737:
3732:
3726:
3722:
3721:
3713:
3711:
3707:
3702:
3696:
3692:
3691:
3683:
3681:
3679:
3675:
3670:
3666:
3661:
3656:
3652:
3648:
3644:
3637:
3635:
3631:
3626:
3622:
3618:
3614:
3610:
3606:
3602:
3598:
3591:
3589:
3587:
3585:
3581:
3575:
3571:
3568:
3566:
3563:
3562:
3558:
3556:
3549:
3547:
3543:
3539:
3535:
3531:
3527:
3523:
3519:
3515:
3511:
3510:Sertaconazole
3507:
3506:Saperconazole
3503:
3499:
3495:
3494:Pramiconazole
3491:
3490:Propiconazole
3487:
3483:
3479:
3475:
3471:
3467:
3463:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3431:
3427:
3423:
3422:Isavuconazole
3419:
3415:
3411:
3407:
3403:
3399:
3398:Fenticonazole
3395:
3391:
3387:
3383:
3382:Efinaconazole
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3354:Cyproconazole
3351:
3347:
3343:
3339:
3338:Chlormidazole
3335:
3331:
3330:Brolaconazole
3327:
3323:
3322:Becliconazole
3319:
3315:
3311:
3307:
3303:
3299:
3296:
3293:
3289:
3285:
3281:
3278:
3274:
3269:
3264:
3263:
3260:
3258:
3254:
3251:
3248:
3244:
3240:
3236:
3233:
3229:
3224:
3219:
3218:
3215:
3213:
3209:
3205:
3201:
3197:
3193:
3190:
3188:
3184:
3181:
3177:
3171:
3166:
3165:
3162:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3132:
3128:
3124:
3121:
3119:
3115:
3111:
3107:
3103:
3099:
3095:
3091:
3088:
3083:
3078:
3077:
3074:
3072:
3068:
3064:
3060:
3056:
3052:
3048:
3044:
3040:
3036:
3032:
3029:
3027:
3023:
3019:
3015:
3012:
3007:
2998:
2993:
2992:
2988:
2984:
2980:
2976:
2973:
2971:
2967:
2963:
2959:
2955:
2951:
2947:
2943:
2939:
2935:
2931:
2930:Valproic acid
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2891:
2887:
2883:
2879:
2875:
2871:
2867:
2863:
2859:
2855:
2851:
2847:
2843:
2839:
2835:
2831:
2830:Propiconazole
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2771:
2767:
2763:
2759:
2755:
2751:
2747:
2743:
2739:
2735:
2731:
2727:
2723:
2719:
2715:
2711:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2679:
2675:
2671:
2667:
2663:
2659:
2658:palmitic acid
2655:
2651:
2650:linoleic acid
2647:
2643:
2639:
2635:
2631:
2627:
2626:Ellagitannins
2623:
2619:
2615:
2611:
2607:
2603:
2599:
2595:
2591:
2587:
2583:
2579:
2575:
2571:
2567:
2566:Ascorbic acid
2563:
2559:
2555:
2551:
2550:Abyssinone II
2547:
2543:
2539:
2535:
2531:
2527:
2524:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2478:
2475:
2471:
2465:
2462:
2461:
2458:
2454:
2450:
2446:
2442:
2438:
2435:
2433:
2429:
2425:
2421:
2417:
2414:
2412:
2408:
2404:
2400:
2396:
2392:
2389:
2385:
2376:
2371:
2370:
2367:
2365:
2361:
2357:
2353:
2349:
2345:
2341:
2337:
2333:
2329:
2325:
2321:
2317:
2313:
2309:
2305:
2304:linoleic acid
2301:
2297:
2293:
2289:
2285:
2281:
2277:
2273:
2269:
2265:
2261:
2257:
2253:
2249:
2248:Δ-Abiraterone
2245:
2242:
2240:
2236:
2232:
2228:
2224:
2220:
2216:
2212:
2208:
2204:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2153:
2149:
2143:
2140:
2139:
2136:
2134:
2130:
2126:
2122:
2118:
2114:
2110:
2106:
2103:
2101:
2097:
2093:
2089:
2085:
2081:
2078:
2074:
2065:
2060:
2059:
2056:
2054:
2050:
2046:
2042:
2038:
2034:
2030:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1994:
1991:
1989:
1985:
1982:
1978:
1973:
1968:
1967:
1964:
1962:
1958:
1954:
1950:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1893:Δ-Abiraterone
1891:
1889:
1885:
1881:
1877:
1874:
1870:
1864:
1861:
1860:
1857:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1784:
1782:
1778:
1774:
1770:
1767:
1763:
1757:
1754:
1753:
1750:
1748:
1744:
1740:
1736:
1732:
1728:
1727:Carbenoxolone
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1697:
1695:
1691:
1688:
1684:
1675:
1670:
1669:
1666:
1664:
1660:
1656:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1624:
1623:Rosiglitazone
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1503:Δ-Abiraterone
1500:
1496:
1493:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1460:
1456:
1451:
1446:
1445:
1442:
1440:
1436:
1432:
1431:Rosiglitazone
1428:
1424:
1420:
1416:
1412:
1408:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1359:Δ-Abiraterone
1356:
1353:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1312:
1308:
1299:
1294:
1293:
1290:
1288:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1233:
1231:
1227:
1223:
1219:
1215:
1211:
1208:
1204:
1195:
1190:
1189:
1186:
1184:
1180:
1176:
1172:
1169:
1167:
1163:
1160:
1155:
1150:
1149:
1146:
1144:
1140:
1136:
1133:
1131:
1127:
1124:
1119:
1114:
1113:
1110:
1108:
1104:
1100:
1096:
1092:
1088:
1085:
1083:
1079:
1075:
1071:
1068:
1063:
1058:
1057:
1054:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1013:
1011:
1007:
1004:
1000:
994:
991:
990:
987:
984:
982:
979:
977:
973:
970:
968:
965:
964:
958:
953:
949:
945:
941:
937:
933:
929:
925:
921:
917:
913:
909:
905:
901:
897:
894:
893:
889:
884:
883:endometriosis
880:
879:breast cancer
876:
872:
868:
864:
860:
856:
852:
849:
848:
844:
843:neurosteroids
840:
836:
832:
828:
825:
824:
820:
819:breast cancer
817:
813:
809:
805:
801:
797:
793:
790:
789:
785:
781:
777:
773:
770:(THDOC), and
769:
765:
761:
757:
753:
749:
745:
741:
737:
733:
729:
725:
722:
721:
717:
713:
709:
705:
701:
697:
693:
690:
689:
685:
680:
679:renal disease
676:
675:heart failure
672:
668:
664:
660:
656:
653:
652:
648:
644:
640:
636:
632:
628:
624:
620:
616:
612:
608:
604:
601:
600:
596:
592:
588:
585:
584:
580:
575:
571:
567:
563:
559:
555:
551:
548:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
496:
495:
491:
487:
483:
479:
475:
471:
467:
463:
459:
456:
455:
451:
446:
442:
438:
434:
430:
423:
418:
414:
410:
406:
403:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
363:
362:
358:
353:
349:
348:
344:
340:
336:
332:
328:
324:
320:
317:
313:
309:
305:
301:
298:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
254:
248:
245:
244:
240:
235:
231:
228:
224:
217:
212:
210:
208:
204:
200:
196:
192:
187:
185:
181:
180:neurosteroids
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
134:
130:
126:
122:
118:
114:
110:
106:
97:
93:
88:
85:
81:
78:
76:
72:
69:
66:
65:Steroidogenic
63:
61:
57:
53:
49:
45:
43:
39:
34:
31:
30:
25:
20:
5289:
5215:
5182:Exopeptidase
5152:Ribonuclease
5118:Janus kinase
5003:Lipoxygenase
4979:5α-Reductase
4901:Pharmacology
4830:
4787:
4783:
4757:
4753:
4711:
4707:
4701:
4674:
4670:
4660:
4627:
4623:
4617:
4582:
4578:
4568:
4548:
4541:
4521:
4514:
4494:
4487:
4467:
4460:
4440:
4433:
4398:
4394:
4359:
4352:
4332:
4325:
4305:
4298:
4281:
4277:
4248:
4218:
4211:
4191:
4184:
4164:
4126:
4080:
4041:
4037:
4027:
4007:
4000:
3980:
3973:
3953:
3921:
3864:
3860:
3850:
3823:
3819:
3809:
3795:
3775:
3768:
3748:
3719:
3689:
3653:(1): 60–71.
3650:
3646:
3600:
3596:
3554:
3546:Zoficonazole
3542:Zinoconazole
3538:Voriconazole
3518:Tebuconazole
3502:Ravuconazole
3486:Posaconazole
3462:Neticonazole
3454:Luliconazole
3446:Lanoconazole
3442:Ketoconazole
3438:Itraconazole
3418:Hexaconazole
3406:Flutrimazole
3390:Enilconazole
3386:Embeconazole
3370:Eberconazole
3362:Diniconazole
3358:Democonazole
3346:Clotrimazole
3334:Butoconazole
3306:Alteconazole
3298:Albaconazole
3288:intermediate
3272:
3253:Ketoconazole
3243:intermediate
3227:
3212:Ravuconazole
3208:Posaconazole
3196:Bicalutamide
3175:
3118:Pregnenolone
3063:butylparaben
2926:Troglitazone
2910:Testolactone
2834:Quinolinoids
2802:Norendoxifen
2766:Leflutrozole
2762:Ketoconazole
2746:tectochrysin
2618:Difeconazole
2602:Clotrimazole
2517:Testosterone
2501:Metandienone
2469:
2383:
2312:monolinolein
2272:Bexlosteride
2268:β-Sitosterol
2264:Azelaic acid
2239:Androstenone
2227:Testosterone
2163:Progesterone
2155:Cholestenone
2147:
2142:5α-Reductase
2092:Testosterone
2072:
2045:Osilodrostat
2033:Ketoconazole
2005:Azelnidipine
1976:
1961:Osilodrostat
1925:Ketoconazole
1868:
1822:Ketoconazole
1802:Clotrimazole
1769:Progesterone
1761:
1747:Progesterone
1682:
1655:Troglitazone
1615:Pioglitazone
1603:Mifepristone
1575:Ketoconazole
1535:Clotrimazole
1470:Progesterone
1462:Pregnenolone
1454:
1439:Troglitazone
1427:Pioglitazone
1423:Oxymetholone
1403:Medrogestone
1342:Testosterone
1318:Progesterone
1314:Pregnenolone
1306:
1271:Ketoconazole
1230:Pregnenolone
1202:
1047:Rosuvastatin
1039:Pitavastatin
1019:Cerivastatin
1015:Atorvastatin
998:
920:voriconazole
912:ketoconazole
908:itraconazole
900:clotrimazole
875:DHEA sulfate
839:DHEA sulfate
812:testolactone
776:side effects
744:testosterone
708:testosterone
671:hypertension
667:osilodrostat
627:osilodrostat
615:ketoconazole
591:progesterone
566:ketoconazole
534:progesterone
530:ketosteroids
474:pregnenolone
466:ketoconazole
437:biosynthesis
343:osteoporosis
311:
276:rosuvastatin
268:atorvastatin
230:biosynthesis
188:
164:progestogens
152:sex steroids
129:biosynthesis
108:
104:
102:
90:Legal status
84:Nonsteroidal
27:
5231:Oxytocinase
5039:Transferase
4579:Endocr. Rev
3534:Valconazole
3530:Uniconazole
3526:Tioconazole
3514:Sulconazole
3482:Penconazole
3478:Parconazole
3474:Oxiconazole
3466:Omoconazole
3434:Isoconazole
3414:Furconazole
3402:Fluconazole
3394:Etaconazole
3350:Croconazole
3342:Cisconazole
3314:Azaconazole
3302:Aliconazole
3235:Cholesterol
3221:Cholesterol
3192:Anastrozole
3183:Cholesterol
3094:Cholesterol
2954:γ-mangostin
2950:α-mangostin
2946:garcinone E
2942:garcinone D
2922:Triadimenol
2918:Triadimefon
2914:Tioconazole
2878:resveratrol
2874:Stilbenoids
2866:zearalenone
2810:Penconazole
2790:Minamestane
2758:Isoconazole
2742:sakuranetin
2730:pinocembrin
2698:biochanin A
2642:Fatty acids
2594:Chalconoids
2562:Anastrozole
2457:Venlafaxine
2445:Mirtazapine
2441:Fluvoxamine
2428:Indometacin
2356:Turosteride
2340:Lapisteride
2332:Izonsteride
2320:Finasteride
2296:Fatty acids
2292:Epristeride
2284:Dutasteride
2260:Alfatradiol
2252:Abiraterone
2211:Aldosterone
2121:Simvastatin
2041:Mespirenone
2021:Efonidipine
2017:Cilnidipine
1988:Aldosterone
1970:Aldosterone
1897:Abiraterone
1854:Tioconazole
1846:Abiraterone
1818:Isoconazole
1790:Amphenone B
1723:Amphenone B
1719:Acetoxolone
1651:Tioconazole
1627:Seviteronel
1571:Isoconazole
1539:Cyanoketone
1515:Amphenone B
1507:Abiraterone
1450:17,20-lyase
1411:Metribolone
1379:Cyanoketone
1371:Amphenone B
1363:Abiraterone
1259:Cyanoketone
1251:Amphenone B
1210:Cholesterol
1171:Azacosterol
1166:Cholesterol
1162:Desmosterol
1130:Cholesterol
1051:Simvastatin
1043:Pravastatin
1027:Fluvastatin
1023:Colestolone
944:antifungals
904:fluconazole
800:anastrozole
740:alfatradiol
736:epristeride
732:dutasteride
728:finasteride
702:(DHEA) and
639:aldosterone
607:amphenone B
574:seviteronel
510:cyanoketone
502:amphenone B
445:cholesterol
417:desmosterol
409:azacosterol
352:colestolone
339:zoledronate
335:risedronate
331:pamidronate
327:ibandronate
323:alendronate
316:nitrogenous
312:circulating
306:(IPP) into
280:simvastatin
227:Cholesterol
144:cholesterol
96:In Wikidata
4714:: 107–11.
3576:References
3470:Orconazole
3458:Miconazole
3366:Doconazole
3326:Bifonazole
3318:Azalanstat
3292:ergosterol
3280:Lanosterol
3266:Lanosterol
3247:bile acids
2979:Flavonoids
2882:Terpenoids
2842:casimiroin
2826:Prochloraz
2822:Plomestane
2806:ORG-33,201
2794:Nimorazole
2786:Miconazole
2750:Formestane
2726:naringenin
2714:hesperetin
2710:gossypetin
2670:Flavonoids
2634:Exemestane
2630:Endosulfan
2610:Coumestrol
2590:CGS-47,645
2586:CGP-45,688
2582:Bifonazole
2574:Atamestane
2493:Nandrolone
2453:Sertraline
2449:Paroxetine
2437:Fluoxetine
2416:Coumestrol
2360:Vitamin B6
2344:Oxendolone
2316:oleic acid
2117:RM-532-105
2037:Metyrapone
2009:Benidipine
1957:Trilostane
1941:Metyrapone
1933:Metomidate
1834:Miconazole
1830:Metyrapone
1794:Bifonazole
1635:Stanozolol
1619:Prochloraz
1607:Nilutamide
1599:Miconazole
1595:MDL-27,302
1591:LY-207,320
1567:Gestrinone
1563:Galeterone
1523:Bifonazole
1519:Bifluranol
1435:Trilostane
1415:Metyrapone
1399:Gestrinone
1287:Trilostane
1179:Triparanol
1143:Triparanol
1035:Mevastatin
1031:Lovastatin
981:Inhibitors
972:Substrates
952:infections
928:lanosterol
924:ergosterol
916:miconazole
804:exemestane
780:depression
754:(BPH) and
696:reversible
659:metyrapone
619:metyrapone
562:galeterone
522:trilostane
413:triparanol
272:lovastatin
234:acetyl-CoA
146:and other
133:endogenous
29:Drug class
16:Drug class
5132:Hydrolase
5096:Integrase
5011:Aromatase
4948:Substrate
4790:: 160–9.
4395:Pituitary
4278:Pharmazie
4060:2002-4436
3669:1849-8922
3374:Econazole
3204:Fadrozole
3071:Triclosan
3055:Genistein
3031:4′OH-CB79
2987:quercetin
2983:genistein
2938:Xanthones
2906:tretinoin
2898:vitamin A
2838:berberine
2814:Phenytoin
2782:MEN-11066
2778:Melatonin
2774:Liarozole
2770:Letrozole
2738:quercetin
2722:myricetin
2694:baicalein
2666:Finrozole
2662:Fenarimol
2638:Fadrozole
2622:Econazole
2570:vitamin C
2521:Estradiol
2497:Estradiol
2464:Aromatase
2424:Genistein
2352:TFM-4AS-1
2328:Gestodene
2100:Estradiol
2029:Fadrozole
2013:Canrenone
1937:Metyrapol
1917:Fadrozole
1913:Etomidate
1909:Canrenone
1838:Midazolam
1814:Genistein
1810:Econazole
1798:Canrenone
1694:Cortisone
1611:Orteronel
1587:Liarozole
1559:Flutamide
1555:Etomidate
1551:Econazole
1527:Canrenone
1395:Genistein
1267:Etomidate
1255:Canrenone
1175:Clomifene
863:irosustat
808:letrozole
716:estradiol
611:etomidate
570:orteronel
558:etomidate
528:into Δ-3-
290:-related
160:estrogens
156:androgens
80:Steroidal
5309:Category
5178:Protease
4812:24116740
4804:25843211
4766:23905452
4736:45817485
4693:26908835
4652:33659983
4644:17023038
4609:26213785
4425:27600150
3617:22217845
3559:See also
3147:SR-16157
3059:Parabens
3051:Galangin
2975:Atrazine
2934:Vorozole
2754:Imazalil
2734:rotenone
2690:apigenin
2686:acacetin
2542:5α-DHNET
2420:Daidzein
2280:Cl-4AS-1
2244:22-Oxime
2203:Cortisol
2133:STX-2624
2129:STX-2622
2125:STX-2171
1972:synthase
1945:Mitotane
1888:Cortisol
1806:Diazepam
1743:licorice
1690:Cortisol
1643:SU-10603
1499:22-Oxime
1391:Epostane
1375:Azastene
1279:Mitotane
1139:BM-15766
986:Inducers
976:Products
940:protozoa
934:of many
831:sulfates
778:such as
762:such as
663:mitotane
631:cortisol
623:mitotane
552:such as
518:mitotane
514:epostane
506:azastene
470:mitotane
373:BM-15766
321:such as
170:such as
154:such as
136:steroids
117:inhibits
42:Synonyms
5204:Trypsin
4728:6238495
4600:4591525
4416:5080363
4290:3325988
3901:6953447
3869:Bibcode
3842:3346239
3625:5876596
3273:CYP51A1
3176:CYP27A1
3159:STX1938
3143:KW-2581
3127:Danazol
3110:Estrone
3061:(e.g.,
3022:Estrone
2981:(e.g.,
2940:(e.g.,
2894:retinol
2884:(e.g.,
2876:(e.g.,
2864:(e.g.,
2836:(e.g.,
2702:chrysin
2682:7,8-DHF
2672:(e.g.,
2644:(e.g.,
2596:(e.g.,
2489:Estrone
2470:CYP19A1
2113:Fisetin
2109:Ethanol
2105:Danazol
2096:Estrone
2063:17β-HSD
1977:CYP11B2
1869:CYP11B1
1762:CYP21A2
1715:ABT-384
1673:11β-HSD
1659:VN/87-1
1639:SU-9055
1547:Danazol
1531:CFG-920
1455:CYP17A1
1387:Danazol
1263:Danazol
1203:CYP11A1
1193:P450scc
1183:WY-3457
1153:24-DHCR
1135:AY-9944
1006:HMG-CoA
867:danazol
712:estrone
383:in the
369:AY-9944
252:HMG-CoA
195:gonadal
148:sterols
121:enzymes
68:enzymes
54:Various
5258:(EC 4)
5134:(EC 3)
5041:(EC 2)
5001:1.13
4958:(EC 1)
4838:
4810:
4802:
4764:
4734:
4726:
4691:
4650:
4642:
4607:
4597:
4556:
4529:
4522:Cancer
4502:
4475:
4448:
4423:
4413:
4367:
4340:
4313:
4288:
4256:
4226:
4199:
4172:
4134:
4088:
4058:
4015:
3988:
3961:
3929:
3899:
3892:346345
3889:
3840:
3783:
3756:
3727:
3697:
3667:
3623:
3615:
3228:CYP7A1
3168:Sterol
3155:STX681
3151:STX213
2966:YM-511
2384:AKR1C4
2374:3α-HSD
2073:HSD17B
2025:FAD286
1683:HSD11B
1495:22-ABC
1297:3β-HSD
1235:22-ABC
1117:7-DHCR
967:Enzyme
918:, and
865:, and
810:, and
738:, and
677:, and
665:, and
637:, and
625:, and
568:, and
520:, and
468:, and
337:, and
278:, and
178:, and
162:, and
127:, the
115:which
5256:Lyase
5216:Mixed
5209:Renin
5187:DPP-4
5022:1.17
5016:COX-2
5009:1.14
4912:Class
4808:S2CID
4732:S2CID
4648:S2CID
4044:(1).
3621:S2CID
3047:Equol
2902:Δ-THC
2858:XHN27
2854:XHN26
2850:XHN22
2798:NKS01
2403:THDOC
2399:DHDOC
2148:SRD5A
1663:YM116
1647:TGF-β
1307:HSD3B
999:HMGCR
936:fungi
926:from
443:from
397:toxic
258:into
232:from
5272:4.2
5264:4.1
5239:3.5
5176:3.4
5158:3.2
5140:3.1
5089:2.7
5081:2.6
5068:2.5
5062:PARP
5060:2.4
5049:COMT
5047:2.1
4993:1.5
4985:1.4
4977:1.3
4964:1.1
4836:ISBN
4800:PMID
4762:PMID
4724:PMID
4689:PMID
4640:PMID
4605:PMID
4554:ISBN
4527:ISBN
4500:ISBN
4473:ISBN
4446:ISBN
4421:PMID
4365:ISBN
4338:ISBN
4311:ISBN
4286:PMID
4254:ISBN
4224:ISBN
4197:ISBN
4170:ISBN
4132:ISBN
4086:ISBN
4056:ISSN
4013:ISBN
3986:ISBN
3959:ISBN
3927:ISBN
3897:PMID
3838:PMID
3781:ISBN
3754:ISBN
3725:ISBN
3695:ISBN
3665:ISSN
3613:PMID
3123:AHBS
3065:) •
2970:Zinc
2964:) •
2908:) •
2880:) •
2868:) •
2860:) •
2748:) •
2706:EGCG
2660:) •
2600:) •
2572:) •
2526:4-AT
2364:Zinc
2336:L-39
2318:) •
1921:FETO
1745:) •
1579:L-39
1355:4-MA
1061:FPPS
946:and
938:and
881:and
873:and
837:and
782:and
645:and
593:and
540:and
484:and
411:and
385:gene
371:and
174:and
138:and
113:drug
5192:ACE
4792:doi
4788:153
4716:doi
4712:123
4679:doi
4632:doi
4595:PMC
4587:doi
4411:PMC
4403:doi
4046:doi
3887:PMC
3877:doi
3828:doi
3824:263
3655:doi
3605:doi
3290:to
3245:to
3081:STS
3005:EST
2996:SST
2900:),
2614:DHT
2578:ATD
439:of
131:of
51:Use
5311::
5180::
4903::
4820:^
4806:.
4798:.
4786:.
4774:^
4758:63
4756:.
4744:^
4730:.
4722:.
4710:.
4687:.
4675:56
4673:.
4669:.
4646:.
4638:.
4628:84
4626:.
4603:.
4593:.
4583:36
4581:.
4577:.
4419:.
4409:.
4399:19
4397:.
4393:.
4379:^
4282:42
4280:.
4268:^
4238:^
4146:^
4100:^
4068:^
4054:.
4040:.
4036:.
3941:^
3909:^
3895:.
3885:.
3875:.
3865:79
3863:.
3859:.
3836:.
3822:.
3818:.
3739:^
3709:^
3677:^
3663:.
3649:.
3645:.
3633:^
3619:.
3611:.
3601:43
3599:.
3583:^
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